## Tue Nov 12 00:34:32 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD1_bin.34.fa -m mmseqs --itype genome -o HFD1_bin.34 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD1_bin.34 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD1_k127_101432_0	234267.Acid_3651	0.0	1380.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD1_k127_101432_8	1267534.KB906759_gene1908	4.195e-59	214.0	2EBPI@1|root,2ZST6@2|Bacteria,3Y4NS@57723|Acidobacteria,2JJ73@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_101432_7	56780.SYN_01077	2.145e-99	335.0	COG0642@1|root,COG0745@1|root,COG3829@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG3829@2|Bacteria,1NWAF@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator, receiver	-	-	2.7.13.3	ko:K07677,ko:K07679,ko:K20974	ko02020,ko02025,ko02026,ko05133,map02020,map02025,map02026,map05133	M00474,M00477,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS_9,Response_reg
HFD1_k127_101432_4	187303.BN69_1421	1.19e-142	490.0	COG0642@1|root,COG0745@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,2TQWE@28211|Alphaproteobacteria,36XHI@31993|Methylocystaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_23075	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_101432_2	1134912.AJTV01000028_gene2039	2.978e-176	561.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2TS3I@28211|Alphaproteobacteria,36XK7@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
HFD1_k127_101432_9	639030.JHVA01000001_gene2685	3.555e-47	171.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XM@57723|Acidobacteria,2JJHR@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_101432_3	234267.Acid_5446	1.866e-150	487.0	COG0665@1|root,COG0665@2|Bacteria,3Y3W7@57723|Acidobacteria	57723|Acidobacteria	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD1_k127_101432_1	234267.Acid_5448	9.903e-243	754.0	COG0156@1|root,COG0156@2|Bacteria	2|Bacteria	E	8-amino-7-oxononanoate synthase activity	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_101432_6	1144275.COCOR_04256	5.112e-113	375.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_101432_5	234267.Acid_5450	2.685e-138	446.0	COG0671@1|root,COG0671@2|Bacteria,3Y90S@57723|Acidobacteria	57723|Acidobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD1_k127_101432_10	246197.MXAN_3746	4.281e-26	113.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_1027461_8	234267.Acid_4473	2.337e-59	214.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K15045	ko05164,map05164	-	-	-	ko00000,ko00001	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HFD1_k127_1027461_9	234267.Acid_4470	3.407e-44	165.0	COG0727@1|root,COG0727@2|Bacteria,3Y4VW@57723|Acidobacteria	57723|Acidobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HFD1_k127_1027461_11	517417.Cpar_0360	2.438e-15	83.0	COG2318@1|root,COG2318@2|Bacteria,1FF75@1090|Chlorobi	1090|Chlorobi	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD1_k127_1027461_0	234267.Acid_3190	8.055e-161	518.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3Y2NW@57723|Acidobacteria	57723|Acidobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD1_k127_1027461_7	1340493.JNIF01000003_gene1324	1.075e-70	245.0	COG0036@1|root,COG0036@2|Bacteria,3Y4QR@57723|Acidobacteria	57723|Acidobacteria	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD1_k127_1027461_1	234267.Acid_3192	1.705e-146	477.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_6,YfiO
HFD1_k127_1027461_6	234267.Acid_3193	1.216e-78	280.0	COG2199@1|root,COG3706@2|Bacteria,3Y5QC@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_1027461_5	234267.Acid_3194	1.073e-82	276.0	COG1666@1|root,COG1666@2|Bacteria,3Y4I3@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HFD1_k127_1027461_4	234267.Acid_3195	1.366e-94	314.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD1_k127_1027461_3	234267.Acid_3198	3.077e-115	374.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HFD1_k127_1027461_10	1267535.KB906767_gene5033	3.737e-41	155.0	COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria,2JK6A@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_1027461_2	1267535.KB906767_gene5034	3.734e-121	418.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1041458_3	1340493.JNIF01000003_gene1814	4.515e-144	496.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_1041458_6	1123392.AQWL01000005_gene2987	5.483e-91	313.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2VHC0@28216|Betaproteobacteria,1KSRW@119069|Hydrogenophilales	119069|Hydrogenophilales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_1041458_2	1340493.JNIF01000003_gene1861	9.493e-273	864.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,TonB_dep_Rec
HFD1_k127_1041458_7	1267535.KB906767_gene277	7.589e-70	244.0	2DB97@1|root,33TRP@2|Bacteria,3Y7NY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1041458_1	682795.AciX8_4155	7.316e-280	880.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD1_k127_1041458_9	411154.GFO_0692	2.414e-19	95.0	COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,1HYF5@117743|Flavobacteriia	976|Bacteroidetes	S	glycosyl hydrolase of	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	DUF4986,Glyco_hydro_127
HFD1_k127_1041458_5	234267.Acid_3656	5.393e-122	396.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HFD1_k127_1041458_4	452637.Oter_1869	1.71e-139	473.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1041458_8	234267.Acid_3406	1.297e-51	186.0	2A07J@1|root,30NAR@2|Bacteria,3Y8MB@57723|Acidobacteria	57723|Acidobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
HFD1_k127_1041458_0	234267.Acid_3405	0.0	1039.0	COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD1_k127_1041458_10	298654.FraEuI1c_2388	2.589e-17	87.0	COG1848@1|root,COG1848@2|Bacteria,2IJ8I@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_1042530_0	234267.Acid_4418	0.0	1480.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1042530_2	234267.Acid_0980	1.08e-39	171.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,CHAT,LCAT
HFD1_k127_1042530_1	1198114.AciX9_1643	1.429e-92	337.0	COG5267@1|root,COG5267@2|Bacteria,3Y6EE@57723|Acidobacteria,2JMGR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD1_k127_1042530_3	377629.TERTU_3754	3.558e-17	93.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,2PPM6@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_1046534_1	234267.Acid_4715	7.443e-129	415.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD1_k127_1046534_0	234267.Acid_4716	2.28e-177	565.0	COG1020@1|root,COG3882@1|root,COG1020@2|Bacteria,COG3882@2|Bacteria	2|Bacteria	Q	phosphopantetheine binding	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,Methyltransf_21,NAD_binding_4,PP-binding
HFD1_k127_1049316_1	1379698.RBG1_1C00001G0047	3.018e-211	666.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HFD1_k127_1049316_10	767817.Desgi_1165	2.719e-88	312.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia	186801|Clostridia	C	PFAM NADH ubiquinone oxidoreductase, 20	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HFD1_k127_1049316_17	1379698.RBG1_1C00001G0049	1.833e-50	184.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	1.8.98.5,1.8.98.6	ko:K14127,ko:K14128	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2083	Fer4,FlpD,HTH_5
HFD1_k127_1049316_2	429009.Adeg_0909	1.278e-173	567.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
HFD1_k127_1049316_3	1267535.KB906767_gene1226	2.841e-172	551.0	COG0076@1|root,COG0076@2|Bacteria,3Y365@57723|Acidobacteria,2JP4F@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HFD1_k127_1049316_7	40571.JOEA01000002_gene4887	7.375e-104	355.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4DZBC@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator with HTH domain and aminotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD1_k127_1049316_20	1340493.JNIF01000003_gene4475	1.147e-33	136.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD1_k127_1049316_0	234267.Acid_5526	5.453e-270	839.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HFD1_k127_1049316_18	234267.Acid_7539	4.073e-40	151.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria	57723|Acidobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_1049316_23	234267.Acid_7541	3.362e-17	84.0	COG0322@1|root,COG0322@2|Bacteria	2|Bacteria	L	excinuclease ABC activity	yurQ	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03703,ko:K04096	ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG
HFD1_k127_1049316_11	234267.Acid_7098	1.906e-87	291.0	COG0503@1|root,COG0503@2|Bacteria,3Y30R@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HFD1_k127_1049316_6	234267.Acid_7097	3.797e-118	395.0	COG1947@1|root,COG1947@2|Bacteria,3Y55D@57723|Acidobacteria	57723|Acidobacteria	I	GHMP kinases N terminal domain	-	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD1_k127_1049316_5	234267.Acid_7096	5.007e-159	510.0	COG0462@1|root,COG0462@2|Bacteria,3Y3KV@57723|Acidobacteria	57723|Acidobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD1_k127_1049316_9	234267.Acid_7095	2.258e-95	316.0	COG1825@1|root,COG1825@2|Bacteria,3Y41C@57723|Acidobacteria	57723|Acidobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD1_k127_1049316_8	234267.Acid_7094	2.822e-98	323.0	COG0193@1|root,COG0193@2|Bacteria,3Y48V@57723|Acidobacteria	57723|Acidobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD1_k127_1049316_13	234267.Acid_7093	2.327e-62	222.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria	57723|Acidobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD1_k127_1049316_16	234267.Acid_7092	5.538e-52	184.0	COG0238@1|root,COG0238@2|Bacteria,3Y53K@57723|Acidobacteria	57723|Acidobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD1_k127_1049316_12	234267.Acid_7091	1.01e-66	231.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria	57723|Acidobacteria	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD1_k127_1049316_4	404589.Anae109_0490	4.596e-170	544.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,42Z8C@68525|delta/epsilon subdivisions,2WU08@28221|Deltaproteobacteria,2YXJP@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1049316_21	1121920.AUAU01000009_gene1956	2.066e-33	135.0	2BVXR@1|root,32QYG@2|Bacteria,3Y86A@57723|Acidobacteria	57723|Acidobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD1_k127_1049316_15	1267535.KB906767_gene2778	2.267e-56	204.0	COG1595@1|root,COG1595@2|Bacteria,3Y7S5@57723|Acidobacteria,2JMWY@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_1049316_19	234267.Acid_7254	2.191e-38	143.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria	57723|Acidobacteria	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD1_k127_1050411_9	234267.Acid_4565	2.161e-100	334.0	COG2304@1|root,COG2304@2|Bacteria,3Y3ER@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1050411_4	234267.Acid_4565	5.44e-168	535.0	COG2304@1|root,COG2304@2|Bacteria,3Y3ER@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1050411_1	234267.Acid_6531	5.711e-181	599.0	COG2272@1|root,COG2272@2|Bacteria,3Y6S1@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_1050411_5	234267.Acid_3068	6.394e-157	529.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	yieL	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_1050411_3	234267.Acid_4334	4.136e-177	561.0	COG0707@1|root,COG0707@2|Bacteria,3Y651@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 28 C-terminal domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C
HFD1_k127_1050411_13	234267.Acid_4335	0.0001273	45.0	COG0671@1|root,COG0671@2|Bacteria,3Y5XF@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD1_k127_1050411_11	234267.Acid_4335	3.941e-15	78.0	COG0671@1|root,COG0671@2|Bacteria,3Y5XF@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD1_k127_1050411_0	234267.Acid_4336	1.515e-263	824.0	COG4805@1|root,COG4805@2|Bacteria,3Y47D@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_1050411_2	234267.Acid_4340	8.216e-181	579.0	COG1055@1|root,COG1055@2|Bacteria,3Y5VM@57723|Acidobacteria	57723|Acidobacteria	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
HFD1_k127_1050411_7	234267.Acid_4341	1.677e-123	406.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888,ko:K20948	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_88
HFD1_k127_1050411_8	234267.Acid_4342	4.651e-120	404.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
HFD1_k127_1050411_6	234267.Acid_2628	3.945e-134	431.0	COG4948@1|root,COG4948@2|Bacteria,3Y46A@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
HFD1_k127_105282_4	234267.Acid_3892	3.038e-115	380.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_105282_8	234267.Acid_4043	3.644e-21	102.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_105282_2	234267.Acid_3616	8.593e-214	668.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_105282_5	234267.Acid_3615	2.94e-64	224.0	2E6AT@1|root,330YQ@2|Bacteria,3Y5M7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_105282_1	234267.Acid_3614	1.888e-216	675.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HFD1_k127_105282_3	234267.Acid_4389	1.741e-179	591.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
HFD1_k127_105282_7	641491.DND132_2311	2.772e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,1N19R@1224|Proteobacteria,42TRS@68525|delta/epsilon subdivisions,2WQHU@28221|Deltaproteobacteria,2MC8X@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	SMART regulatory protein ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HFD1_k127_105282_9	795359.TOPB45_0890	2.211e-17	86.0	COG0526@1|root,COG0526@2|Bacteria,2GI1G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HFD1_k127_105282_6	748658.KB907312_gene1639	2.582e-32	129.0	2DMHQ@1|root,32RMG@2|Bacteria,1RI3A@1224|Proteobacteria,1S7NG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Arsenical resistance operon trans-acting repressor arsD	arsD	-	-	-	-	-	-	-	-	-	-	-	ArsD
HFD1_k127_105282_0	269482.Bcep1808_4680	4.44e-224	713.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,1K4KH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Arsenite-activated ATPase (ArsA)	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
HFD1_k127_106056_0	639030.JHVA01000001_gene603	9.289e-137	465.0	COG1629@1|root,COG1629@2|Bacteria,3Y2JN@57723|Acidobacteria,2JI08@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_106056_1	1218075.BAYA01000006_gene2360	5.69e-63	222.0	COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2VIKS@28216|Betaproteobacteria,1KIDW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Major facilitator Superfamily	pcaK	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4
HFD1_k127_1067373_1	234267.Acid_5857	5.368e-178	560.0	COG0243@1|root,COG0243@2|Bacteria,3Y2IU@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD1_k127_1067373_2	404589.Anae109_1578	1.345e-13	83.0	2AG2N@1|root,31670@2|Bacteria,1NNB1@1224|Proteobacteria,437DW@68525|delta/epsilon subdivisions,2X2K1@28221|Deltaproteobacteria,2Z2S0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1067373_0	234267.Acid_5855	5.499e-206	649.0	COG0579@1|root,COG0579@2|Bacteria,3Y6NN@57723|Acidobacteria	57723|Acidobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
HFD1_k127_1073833_9	234267.Acid_7892	6.597e-36	138.0	COG1721@1|root,COG1721@2|Bacteria,3Y5V9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD1_k127_1073833_2	234267.Acid_7126	3.697e-211	674.0	COG0673@1|root,COG0673@2|Bacteria,3Y7D9@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1073833_4	234267.Acid_7125	2.364e-84	280.0	COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria	57723|Acidobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_1073833_6	440512.C211_15085	2.403e-51	186.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,1S69D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HFD1_k127_1073833_8	234267.Acid_3620	1.197e-40	153.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_1073833_11	234267.Acid_4795	3.785e-30	133.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1073833_5	234267.Acid_7944	7.718e-73	267.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1073833_13	1415780.JPOG01000001_gene710	5.669e-11	73.0	COG1724@1|root,COG1724@2|Bacteria,1NGKC@1224|Proteobacteria,1SHG3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HFD1_k127_1073833_7	1247726.MIM_c27650	5.488e-41	157.0	COG1598@1|root,COG1598@2|Bacteria,1RI8S@1224|Proteobacteria,2W3B2@28216|Betaproteobacteria,3T50J@506|Alcaligenaceae	28216|Betaproteobacteria	S	Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin	-	-	-	ko:K18843	-	-	-	-	ko00000,ko02048	-	-	-	HicB-like_2,HicB_lk_antitox
HFD1_k127_1073833_12	485913.Krac_5359	6.292e-23	107.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_1073833_0	234267.Acid_6654	0.0	1776.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_1073833_10	234267.Acid_5212	4.989e-34	140.0	2DR6B@1|root,33ACQ@2|Bacteria,3Y949@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1073833_1	234267.Acid_7082	2.546e-279	866.0	COG0362@1|root,COG0362@2|Bacteria,3Y3UI@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD1_k127_1073833_3	234267.Acid_7084	1.194e-185	587.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD1_k127_1088277_6	234267.Acid_0087	1.235e-167	532.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	Acyl-CoA_dh_1,ETF,ETF_alpha
HFD1_k127_1088277_7	1232410.KI421426_gene1400	6.551e-157	500.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,42PW8@68525|delta/epsilon subdivisions,2WKCT@28221|Deltaproteobacteria,43UTD@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
HFD1_k127_1088277_9	234267.Acid_7766	1.175e-121	397.0	COG1597@1|root,COG1597@2|Bacteria,3Y58A@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD1_k127_1088277_0	234267.Acid_7765	1.025e-318	987.0	COG0272@1|root,COG0272@2|Bacteria,3Y2UR@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD1_k127_1088277_17	234267.Acid_6847	1.493e-28	121.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_1088277_19	234267.Acid_6791	3.87e-08	59.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD1_k127_1088277_8	1267533.KB906740_gene290	7.568e-126	430.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HFD1_k127_1088277_18	1121373.KB903620_gene2119	1.357e-17	97.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NKPZ@976|Bacteroidetes,47NIF@768503|Cytophagia	976|Bacteroidetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_8
HFD1_k127_1088277_2	234267.Acid_0434	6.579e-210	667.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,FAD_oxidored,GMC_oxred_C,GMC_oxred_N
HFD1_k127_1088277_3	234267.Acid_6111	2.862e-180	579.0	COG2234@1|root,COG2234@2|Bacteria,3Y341@57723|Acidobacteria	2|Bacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_1088277_5	234267.Acid_0457	3.407e-171	550.0	COG0348@1|root,COG0348@2|Bacteria,3Y3H4@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
HFD1_k127_1088277_13	204669.Acid345_0365	3.604e-69	243.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria,2JMU3@204432|Acidobacteriia	204432|Acidobacteriia	D	Domain of Unknown function (DUF542)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HFD1_k127_1088277_11	204669.Acid345_0362	3.847e-88	296.0	COG0664@1|root,COG0664@2|Bacteria,3Y4WU@57723|Acidobacteria,2JMTC@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_1088277_12	234267.Acid_7800	2.01e-74	256.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HFD1_k127_1088277_1	234267.Acid_7789	5.262e-231	738.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
HFD1_k127_1088277_4	234267.Acid_7785	1.073e-173	556.0	COG4972@1|root,COG4972@2|Bacteria	2|Bacteria	NU	Pilus assembly protein	-	-	-	ko:K02461,ko:K02662	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	PilM_2,PilN,T2SSL
HFD1_k127_1088277_10	234267.Acid_7784	7.227e-100	337.0	COG3156@1|root,COG3156@2|Bacteria	2|Bacteria	U	protein secretion	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HFD1_k127_1091349_0	1340493.JNIF01000003_gene3160	1.505e-170	558.0	COG1984@1|root,COG1984@2|Bacteria	2|Bacteria	E	allophanate hydrolase subunit 2	kipA	-	6.3.4.6	ko:K01941,ko:K06350	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	CT_A_B,CT_C_D,SLH
HFD1_k127_1091349_1	234267.Acid_1946	1.926e-82	287.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1946|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1091349_2	530564.Psta_3944	2.444e-54	195.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_1100270_1	234267.Acid_6426	3.268e-127	411.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HFD1_k127_1100270_4	234267.Acid_4367	1.08e-17	86.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin,YafQ_toxin
HFD1_k127_1100270_2	1267535.KB906767_gene2380	9.122e-91	301.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD1_k127_1100270_3	1267535.KB906767_gene2380	3.803e-53	188.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD1_k127_1100270_0	1267535.KB906767_gene3474	2.374e-175	554.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1123443_0	1267535.KB906767_gene884	4.893e-318	980.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1123443_2	709986.Deima_1104	1.189e-133	456.0	COG1696@1|root,COG1696@2|Bacteria	2|Bacteria	M	negative regulation of protein lipidation	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HFD1_k127_1123443_4	864051.BurJ1DRAFT_3158	1.016e-91	314.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	aceE	-	1.2.4.1,1.8.1.4,2.3.1.12	ko:K00163,ko:K00382,ko:K00627	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00014,R00209,R01221,R01698,R01699,R02569,R03270,R03815,R07618,R08549	RC00004,RC00022,RC00027,RC00583,RC00627,RC02742,RC02744,RC02833,RC02834,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,E3_binding,Pyr_redox_2,Transketolase_N
HFD1_k127_1123443_1	864051.BurJ1DRAFT_3157	2.914e-237	754.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2W0PN@28216|Betaproteobacteria	28216|Betaproteobacteria	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD1_k127_1123443_5	1207076.ALAT01000006_gene1339	9.514e-23	101.0	COG0236@1|root,COG0236@2|Bacteria,1N72R@1224|Proteobacteria,1SIIH@1236|Gammaproteobacteria,1Z39B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	IQ	acyl carrier protein	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD1_k127_1123443_6	1453503.AU05_12450	2.469e-05	57.0	2DM6Q@1|root,31Y0D@2|Bacteria,1RKVP@1224|Proteobacteria,1SYEE@1236|Gammaproteobacteria,1YEEX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	ko:K19295	-	-	-	-	ko00000	-	-	-	ALGX
HFD1_k127_1123443_3	234267.Acid_4473	1.064e-131	422.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K15045	ko05164,map05164	-	-	-	ko00000,ko00001	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HFD1_k127_1135665_4	1340493.JNIF01000003_gene4087	1.337e-139	449.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1135665_7	1340493.JNIF01000003_gene4093	8.508e-75	276.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	DUF11,VCBS
HFD1_k127_1135665_3	234267.Acid_7433	3.123e-146	486.0	COG0006@1|root,COG0006@2|Bacteria,3Y3IN@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD1_k127_1135665_0	234267.Acid_7431	3.794e-236	746.0	COG3852@1|root,COG3852@2|Bacteria,3Y9B5@57723|Acidobacteria	57723|Acidobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_1135665_2	234267.Acid_7430	8.716e-157	502.0	COG0604@1|root,COG0604@2|Bacteria,3Y35U@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_1135665_8	234267.Acid_7429	3.6e-62	219.0	2F82T@1|root,340G8@2|Bacteria,3Y8B9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1135665_9	234267.Acid_7719	1.819e-59	217.0	COG1225@1|root,COG1225@2|Bacteria,3Y4Z6@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_1135665_1	644282.Deba_0849	6.386e-176	564.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD1_k127_1135665_5	234267.Acid_7723	8.232e-115	383.0	COG0689@1|root,COG0689@2|Bacteria,3Y2FP@57723|Acidobacteria	57723|Acidobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HFD1_k127_1135665_6	234267.Acid_7724	1.999e-75	269.0	COG0127@1|root,COG0127@2|Bacteria,3Y7Z7@57723|Acidobacteria	57723|Acidobacteria	F	Ham1 family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD1_k127_1135665_15	445972.ANACOL_03340	2.697e-06	53.0	COG1357@1|root,COG1357@2|Bacteria,1VCZ3@1239|Firmicutes,25BMA@186801|Clostridia	186801|Clostridia	S	Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HFD1_k127_1135665_11	194439.CT1045	2.856e-40	166.0	COG1357@1|root,COG1357@2|Bacteria,1FEKU@1090|Chlorobi	1090|Chlorobi	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,TIR_2
HFD1_k127_1150087_4	234267.Acid_2629	8.281e-61	238.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1150087_7	278963.ATWD01000002_gene561	6.898e-10	73.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AhpC-TSA,CarboxypepD_reg,PDZ_2,Plug,TonB_dep_Rec
HFD1_k127_1150087_3	234267.Acid_5554	4.416e-95	328.0	COG0580@1|root,COG0580@2|Bacteria,3Y3AE@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
HFD1_k127_1150087_1	234267.Acid_5555	4.051e-254	792.0	COG0554@1|root,COG0554@2|Bacteria,3Y37H@57723|Acidobacteria	57723|Acidobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD1_k127_1150087_6	234267.Acid_0514	1.716e-37	155.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria	57723|Acidobacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HFD1_k127_1150087_2	234267.Acid_5230	6.061e-156	514.0	COG0489@1|root,COG0489@2|Bacteria,3Y38H@57723|Acidobacteria	57723|Acidobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HFD1_k127_1150087_5	234267.Acid_3601	1.917e-50	189.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HFD1_k127_1150087_8	1227739.Hsw_3635	9.855e-06	57.0	COG1404@1|root,COG1404@2|Bacteria,4NT59@976|Bacteroidetes,47YNA@768503|Cytophagia	976|Bacteroidetes	O	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HFD1_k127_1150087_0	234267.Acid_5315	0.0	1660.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_1152208_0	1267535.KB906767_gene1540	1.494e-224	734.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1152208_7	1267535.KB906767_gene2197	3.159e-74	261.0	COG1082@1|root,COG1082@2|Bacteria,3Y73B@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_1152208_1	234267.Acid_5952	6.817e-215	713.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_1152208_6	1313304.CALK_1498	1.358e-96	343.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_1152208_4	1313304.CALK_1497	1.883e-134	439.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD1_k127_1152208_5	1121481.AUAS01000002_gene3332	4.065e-132	439.0	COG1680@1|root,COG1680@2|Bacteria,4NEEP@976|Bacteroidetes,47KW2@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_1152208_2	234267.Acid_1514	1.755e-179	583.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1152208_8	1487953.JMKF01000043_gene2602	2.584e-29	130.0	COG0783@1|root,COG0783@2|Bacteria,1G4ZH@1117|Cyanobacteria,1HF68@1150|Oscillatoriales	1117|Cyanobacteria	P	Ferritin-like domain	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HFD1_k127_1152208_3	234267.Acid_2515	2.325e-157	501.0	COG0075@1|root,COG0075@2|Bacteria,3Y2Q8@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_116498_1	234267.Acid_5860	7.039e-164	534.0	COG1807@1|root,COG1807@2|Bacteria,3Y7PC@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_116498_2	1267535.KB906767_gene4880	1.241e-21	110.0	COG0500@1|root,COG0500@2|Bacteria,3Y94A@57723|Acidobacteria	57723|Acidobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_116498_0	234267.Acid_5857	1.102e-205	644.0	COG0243@1|root,COG0243@2|Bacteria,3Y2IU@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD1_k127_1169993_5	234267.Acid_6175	8.416e-94	345.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	BACON,CarboxypepD_reg,DUF11,Lipase_GDSL_2,NPCBM_assoc,PA14,RicinB_lectin_2,VPEP
HFD1_k127_1169993_1	234267.Acid_0041	4.377e-300	937.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1169993_9	1267535.KB906767_gene2990	5.185e-12	76.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1169993_7	1267535.KB906767_gene5108	5.079e-24	109.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1169993_2	234267.Acid_0040	2.733e-234	727.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_1169993_0	234267.Acid_7916	6.346e-304	960.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_1169993_6	234267.Acid_7915	4.674e-71	247.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_1169993_3	234267.Acid_0058	8.486e-177	560.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_1169993_8	880073.Calab_3008	9.782e-23	115.0	COG1629@1|root,COG4771@2|Bacteria,2NRBR@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_1169993_4	234267.Acid_1837	2.334e-100	340.0	COG2423@1|root,COG2423@2|Bacteria,3Y82U@57723|Acidobacteria	57723|Acidobacteria	E	PFAM ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD1_k127_1184342_2	644968.DFW101_1322	2.351e-34	140.0	COG1203@1|root,COG1203@2|Bacteria,1MX7A@1224|Proteobacteria,42Q2Q@68525|delta/epsilon subdivisions,2WJEP@28221|Deltaproteobacteria,2M900@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	TIGRFAM CRISPR-associated	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,HD,Helicase_C,ResIII
HFD1_k127_1184342_0	234267.Acid_4101	6.044e-217	685.0	COG0577@1|root,COG0577@2|Bacteria,3Y6CK@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_1184342_1	234267.Acid_4102	1.495e-57	202.0	COG0845@1|root,COG0845@2|Bacteria,3Y6E7@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1187256_1	234267.Acid_3774	5.417e-208	680.0	COG2202@1|root,COG2204@1|root,COG3437@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3Y78F@57723|Acidobacteria	2|Bacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	1.8.1.9,2.7.13.3,3.4.21.53	ko:K00384,ko:K01338,ko:K11527	ko00450,ko04112,map00450,map04112	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko01001,ko01002,ko02022	-	-	-	HATPase_c,HTH_8,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_1187256_6	517417.Cpar_1554	2.893e-61	226.0	COG0457@1|root,COG0457@2|Bacteria,1FD7Y@1090|Chlorobi	517417.Cpar_1554|-	K	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1187256_8	234267.Acid_2578	1.026e-48	178.0	COG2947@1|root,COG2947@2|Bacteria,3Y54W@57723|Acidobacteria	57723|Acidobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD1_k127_1187256_9	1340493.JNIF01000003_gene2984	5.066e-19	91.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HFD1_k127_1187256_0	234267.Acid_1653	1.155e-239	746.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD1_k127_1187256_4	234267.Acid_1651	8.078e-111	370.0	COG2220@1|root,COG2220@2|Bacteria,3Y739@57723|Acidobacteria	57723|Acidobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD1_k127_1187256_7	234267.Acid_1797	2.166e-55	197.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_4
HFD1_k127_1187256_11	234267.Acid_2618	1.041e-05	48.0	COG4219@1|root,COG4219@2|Bacteria,3Y9A7@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_1187256_2	234267.Acid_5621	7.003e-170	539.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,FlgD_ig,NHL
HFD1_k127_1187256_3	234267.Acid_5622	4.09e-144	481.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,FlgD_ig,NHL
HFD1_k127_1187256_5	1340493.JNIF01000003_gene4382	3.169e-84	286.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1200150_8	234267.Acid_5915	4.388e-147	467.0	COG0003@1|root,COG0071@1|root,COG0003@2|Bacteria,COG0071@2|Bacteria,3Y60Y@57723|Acidobacteria	57723|Acidobacteria	OP	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HFD1_k127_1200150_14	1033743.CAES01000035_gene1279	8.924e-63	233.0	COG2755@1|root,COG2755@2|Bacteria,1VAM0@1239|Firmicutes,4HU6D@91061|Bacilli,26RDP@186822|Paenibacillaceae	91061|Bacilli	E	N-terminus of Esterase_SGNH_hydro-type	-	-	-	-	-	-	-	-	-	-	-	-	GxDLY,Lipase_GDSL_3
HFD1_k127_1200150_1	234267.Acid_5634	2.597e-264	847.0	COG0823@1|root,COG4447@1|root,COG0823@2|Bacteria,COG4447@2|Bacteria,3Y9AF@57723|Acidobacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Peptidase_S8,SBBP
HFD1_k127_1200150_13	234267.Acid_5304	1.512e-91	306.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
HFD1_k127_1200150_5	234267.Acid_4965	1.329e-164	548.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1200150_4	234267.Acid_2668	8.394e-204	636.0	COG0407@1|root,COG0407@2|Bacteria,3Y8YA@57723|Acidobacteria	57723|Acidobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD1_k127_1200150_11	234267.Acid_2669	3.246e-109	357.0	COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria	57723|Acidobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HFD1_k127_1200150_3	234267.Acid_2671	3.492e-216	691.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,3Y7VX@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HFD1_k127_1200150_9	234267.Acid_2672	7.949e-147	474.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
HFD1_k127_1200150_6	234267.Acid_2673	1.11e-155	495.0	COG0646@1|root,COG0646@2|Bacteria,3Y7SY@57723|Acidobacteria	57723|Acidobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HFD1_k127_1200150_19	382464.ABSI01000009_gene3978	1.232e-27	117.0	2EE3M@1|root,337Y7@2|Bacteria,46VPI@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1200150_2	234267.Acid_2667	4.147e-237	741.0	COG4948@1|root,COG4948@2|Bacteria,3Y4P2@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_1200150_0	234267.Acid_2666	0.0	1090.0	COG3661@1|root,COG3661@2|Bacteria,3Y2TM@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 67 family	-	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
HFD1_k127_1200150_10	234267.Acid_6584	2.091e-113	376.0	COG2321@1|root,COG2321@2|Bacteria,3Y3WQ@57723|Acidobacteria	57723|Acidobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD1_k127_1200150_22	234267.Acid_6742	3.83e-14	80.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
HFD1_k127_1200150_7	234267.Acid_4011	6.487e-153	493.0	COG3503@1|root,COG3503@2|Bacteria,3Y3XK@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD1_k127_1200150_16	1340493.JNIF01000003_gene2361	2.151e-37	143.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_1200150_23	529818.AMSG_02016T0	0.0002687	53.0	28KFM@1|root,2QSWR@2759|Eukaryota	2759|Eukaryota	S	Golgi organization	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0006996,GO:0007030,GO:0008150,GO:0009987,GO:0010256,GO:0012505,GO:0016043,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097708	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1200150_12	234267.Acid_3256	2.317e-104	350.0	COG2259@1|root,COG2259@2|Bacteria,3Y7PU@57723|Acidobacteria	57723|Acidobacteria	S	Doxx family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1200150_17	1267535.KB906767_gene457	2.44e-34	143.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_121425_1	234267.Acid_0767	2.706e-37	143.0	COG0636@1|root,COG0636@2|Bacteria,3Y59E@57723|Acidobacteria	57723|Acidobacteria	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD1_k127_121425_0	234267.Acid_0766	3.879e-108	355.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD1_k127_121425_4	1267533.KB906738_gene2115	1.245e-07	60.0	COG5336@1|root,COG5336@2|Bacteria,3Y5UJ@57723|Acidobacteria,2JNF6@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
HFD1_k127_121425_2	234267.Acid_2696	6.061e-34	138.0	COG0726@1|root,COG3227@1|root,COG3386@1|root,COG4719@1|root,COG0726@2|Bacteria,COG3227@2|Bacteria,COG3386@2|Bacteria,COG4719@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K14274,ko:K20274	ko00040,ko02024,map00040,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002	-	-	-	CarboxypepD_reg,DUF11,DUF5122,FTP,He_PIG,NHL,Peptidase_M36,SGL
HFD1_k127_1216005_4	234267.Acid_0482	8.439e-48	171.0	COG0403@1|root,COG0403@2|Bacteria,3Y2WZ@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD1_k127_1216005_5	234267.Acid_0483	2.609e-47	184.0	COG0509@1|root,COG0509@2|Bacteria,3Y55C@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD1_k127_1216005_0	234267.Acid_0484	6.172e-203	635.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD1_k127_1216005_3	234267.Acid_0485	8.729e-57	200.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_0485|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1216005_6	313606.M23134_01815	2.064e-20	101.0	COG2220@1|root,COG2220@2|Bacteria,4NVGR@976|Bacteroidetes	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD1_k127_1216005_1	234267.Acid_0488	1.081e-156	504.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase T2 asparaginase 2	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
HFD1_k127_1216005_2	234267.Acid_0489	5.94e-66	227.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD1_k127_1218894_1	713586.KB900536_gene1112	2.232e-33	135.0	COG4083@1|root,COG4083@2|Bacteria,1RI8D@1224|Proteobacteria,1S812@1236|Gammaproteobacteria,1X10E@135613|Chromatiales	135613|Chromatiales	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HFD1_k127_1218894_0	234267.Acid_7844	5.414e-107	349.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD1_k127_124285_2	1267535.KB906767_gene3571	1.64e-129	443.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_124285_0	234267.Acid_4058	1.166e-234	736.0	COG1649@1|root,COG1649@2|Bacteria,3Y2XT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_124285_6	861299.J421_1012	3.006e-55	208.0	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	-	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD1_k127_124285_7	1121013.P873_11020	1.258e-16	84.0	COG1598@1|root,COG1598@2|Bacteria,1NBIX@1224|Proteobacteria,1SCV3@1236|Gammaproteobacteria,1XBIM@135614|Xanthomonadales	135614|Xanthomonadales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD1_k127_124285_8	65093.PCC7418_3178	5.225e-15	76.0	COG1724@1|root,COG1724@2|Bacteria,1G91K@1117|Cyanobacteria	1117|Cyanobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_124285_1	1267535.KB906767_gene3137	1.261e-184	605.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HFD1_k127_124285_4	1340493.JNIF01000003_gene4437	1.258e-79	278.0	COG2096@1|root,COG2096@2|Bacteria,3Y622@57723|Acidobacteria	57723|Acidobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HFD1_k127_124285_3	234267.Acid_5138	5.133e-81	284.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD1_k127_124285_5	1340493.JNIF01000003_gene4439	6.65e-64	229.0	COG1492@1|root,COG1492@2|Bacteria,3Y64K@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HFD1_k127_124827_3	1267535.KB906767_gene3728	1.39e-105	361.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_124827_10	234267.Acid_5940	3.962e-30	131.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_124827_13	204669.Acid345_0263	2.42e-05	56.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_124827_0	234267.Acid_6137	2.395e-299	957.0	COG4932@1|root,COG4932@2|Bacteria,3Y6F1@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_124827_9	234267.Acid_6264	2.957e-46	169.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD1_k127_124827_4	1267535.KB906767_gene3454	9.128e-97	327.0	COG4299@1|root,COG4299@2|Bacteria,3Y3Q4@57723|Acidobacteria	2|Bacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
HFD1_k127_124827_1	234267.Acid_2982	2.801e-247	804.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_2982|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_124827_5	158500.BV97_04492	3.937e-94	323.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria,2K1RI@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
HFD1_k127_124827_12	1340493.JNIF01000003_gene1578	3.84e-09	65.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
HFD1_k127_124827_8	649747.HMPREF0083_01933	5.179e-61	227.0	COG2208@1|root,COG3829@1|root,COG2208@2|Bacteria,COG3829@2|Bacteria,1TS3B@1239|Firmicutes,4HCRR@91061|Bacilli,26RAI@186822|Paenibacillaceae	91061|Bacilli	T	response regulator	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_3,PAS_9,Response_reg,SpoIIE
HFD1_k127_124827_6	234267.Acid_5653	5.143e-71	242.0	2EE9W@1|root,3384B@2|Bacteria	2|Bacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	cbcS	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
HFD1_k127_124827_2	234267.Acid_5652	1.466e-138	442.0	COG0437@1|root,COG0437@2|Bacteria,3Y81X@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD1_k127_124827_7	234267.Acid_5651	1.478e-66	229.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD1_k127_1250900_2	234267.Acid_2159	1.425e-83	289.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
HFD1_k127_1250900_0	234267.Acid_1889	4.379e-312	965.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_1250900_1	234267.Acid_1890	6.099e-236	744.0	COG4178@1|root,COG4178@2|Bacteria	2|Bacteria	P	(ABC) transporter	-	-	-	ko:K02021,ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.203.11,3.A.1.203.4,3.A.1.21	-	-	ABC_membrane_2,ABC_tran
HFD1_k127_1258270_1	234267.Acid_0100	7.585e-92	309.0	293RY@1|root,2ZR7G@2|Bacteria,3Y953@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1258270_2	234267.Acid_1440	2.026e-55	204.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
HFD1_k127_1258270_0	234267.Acid_1818	2.973e-162	513.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD1_k127_1274891_0	234267.Acid_2885	3.302e-148	488.0	COG2202@1|root,COG3437@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3Y2H6@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
HFD1_k127_1274891_6	234267.Acid_3361	1.355e-11	68.0	COG0784@1|root,COG2202@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_1274891_1	1156919.QWC_26283	1.374e-83	307.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HFD1_k127_1274891_4	649638.Trad_1088	8.946e-61	237.0	COG0036@1|root,COG0036@2|Bacteria,1WI8K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD1_k127_1274891_3	1267534.KB906754_gene2615	8.761e-63	221.0	2C852@1|root,32YB2@2|Bacteria,3Y55S@57723|Acidobacteria,2JJNG@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD1_k127_1274891_2	234267.Acid_4261	1.973e-77	267.0	291KW@1|root,2ZP77@2|Bacteria,3Y94F@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD1_k127_1274891_5	1232410.KI421426_gene1474	1.219e-44	177.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,43DHA@68525|delta/epsilon subdivisions,2X8P3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD1_k127_1277529_1	234267.Acid_6648	0.0	1214.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_6648|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1277529_0	234267.Acid_6648	0.0	1796.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_6648|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1277529_4	234267.Acid_6649	1.035e-56	203.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
HFD1_k127_1277529_2	234267.Acid_6650	2.244e-167	548.0	COG0006@1|root,COG0006@2|Bacteria,3Y460@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD1_k127_1277529_3	234267.Acid_6651	1.891e-144	461.0	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD1_k127_1288947_3	861299.J421_6020	1.587e-07	55.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	csxA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575	3.2.1.165	ko:K15855	ko00520,ko01100,map00520,map01100	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	CBM_35,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_1288947_2	484770.UFO1_3005	9.027e-116	390.0	COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,4H65I@909932|Negativicutes	909932|Negativicutes	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_1288947_0	234267.Acid_2151	0.0	1304.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	2|Bacteria	S	PFAM LmbE family protein	mca	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	NPCBM_assoc,PIG-L
HFD1_k127_1288947_1	1267535.KB906767_gene1087	5.705e-171	545.0	COG4993@1|root,COG4993@2|Bacteria,3Y6W9@57723|Acidobacteria,2JKUB@204432|Acidobacteriia	204432|Acidobacteriia	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_1303151_0	1440053.JOEI01000006_gene2668	4.314e-166	527.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD1_k127_1303151_1	1121377.KB906410_gene608	7.886e-10	59.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HFD1_k127_1307045_0	234267.Acid_7066	7.519e-233	725.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_1307045_1	234267.Acid_7065	1.537e-156	499.0	28M67@1|root,31CRD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1307045_2	234267.Acid_7029	3.646e-18	86.0	COG1295@1|root,COG1295@2|Bacteria,3Y3AJ@57723|Acidobacteria	57723|Acidobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD1_k127_1314121_0	1219035.NT2_11_00270	8.036e-72	261.0	COG2885@1|root,COG4625@1|root,COG2885@2|Bacteria,COG4625@2|Bacteria,1N6EM@1224|Proteobacteria,2U17R@28211|Alphaproteobacteria,2K18P@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,OMP_b-brl,OmpA
HFD1_k127_1314638_0	1122931.AUAE01000031_gene2866	2.83e-209	664.0	COG1653@1|root,COG1653@2|Bacteria,4NG6U@976|Bacteroidetes,2FRMG@200643|Bacteroidia,2310A@171551|Porphyromonadaceae	976|Bacteroidetes	G	Periplasmic copper-binding protein (NosD)	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Beta_helix,DUF1565
HFD1_k127_132074_0	234267.Acid_6845	1.015e-105	357.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria,3Y83C@57723|Acidobacteria	57723|Acidobacteria	I	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD1_k127_132074_2	1206744.BAGL01000052_gene2333	6.474e-29	116.0	COG3558@1|root,COG3558@2|Bacteria,2IFFG@201174|Actinobacteria,4G0PS@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1348)	-	-	-	ko:K09958	-	-	-	-	ko00000	-	-	-	DUF1348
HFD1_k127_132074_3	311403.Arad_4511	2.867e-23	102.0	COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,2U5FW@28211|Alphaproteobacteria,4BA8V@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1348)	-	-	-	ko:K09958	-	-	-	-	ko00000	-	-	-	DUF1348
HFD1_k127_132074_1	1131814.JAFO01000001_gene2157	1.674e-49	191.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3F243@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	ahpD	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_132074_4	1192034.CAP_5352	1.873e-09	66.0	COG0664@1|root,COG0664@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2YVYQ@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,cNMP_binding
HFD1_k127_1324924_8	234267.Acid_5748	2.551e-11	68.0	COG1350@1|root,COG1350@2|Bacteria,3Y7FQ@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_1324924_2	1267535.KB906767_gene5074	1.236e-79	269.0	COG2193@1|root,COG2193@2|Bacteria,3Y56Z@57723|Acidobacteria,2JMWM@204432|Acidobacteriia	204432|Acidobacteriia	C	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD1_k127_1324924_5	234267.Acid_7236	9.653e-43	160.0	297GA@1|root,2ZUPK@2|Bacteria,3Y8WK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1324924_0	234267.Acid_7235	3.188e-157	504.0	COG0583@1|root,COG0583@2|Bacteria,3Y4EH@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_1324924_4	234267.Acid_0337	2.796e-45	166.0	COG1815@1|root,COG1815@2|Bacteria,3Y5BH@57723|Acidobacteria	57723|Acidobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
HFD1_k127_1324924_3	234267.Acid_0338	2.073e-63	226.0	COG1558@1|root,COG1558@2|Bacteria,3Y538@57723|Acidobacteria	57723|Acidobacteria	N	flagellar basal-body rod protein FlgC	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD1_k127_1324924_6	234267.Acid_0339	2.387e-24	105.0	COG1677@1|root,COG1677@2|Bacteria	2|Bacteria	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
HFD1_k127_1324924_1	234267.Acid_0340	3.064e-131	424.0	COG1766@1|root,COG1766@2|Bacteria,3Y2HU@57723|Acidobacteria	57723|Acidobacteria	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
HFD1_k127_1331280_2	1187851.A33M_1371	5.901e-102	340.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,3FCZX@34008|Rhodovulum	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_1331280_7	1304872.JAGC01000003_gene2399	2.851e-28	123.0	2EGCD@1|root,33A46@2|Bacteria,1NW0E@1224|Proteobacteria,43EB0@68525|delta/epsilon subdivisions,2X07C@28221|Deltaproteobacteria,2MB07@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1331280_4	234267.Acid_4514	1.113e-84	284.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria	57723|Acidobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD1_k127_1331280_5	234267.Acid_5564	5.104e-46	175.0	COG2968@1|root,COG2968@2|Bacteria,3Y844@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HFD1_k127_1331280_0	234267.Acid_5563	1.881e-243	762.0	COG5267@1|root,COG5267@2|Bacteria,3Y342@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD1_k127_1331280_1	234267.Acid_5562	1.409e-207	651.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_1331280_6	234267.Acid_1238	3.262e-33	138.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_1331280_3	1123277.KB893182_gene4744	1.925e-97	326.0	COG3250@1|root,COG3533@1|root,COG3250@2|Bacteria,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,47T8T@768503|Cytophagia	976|Bacteroidetes	G	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD1_k127_1332988_0	234267.Acid_0690	6.274e-198	633.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria	57723|Acidobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD1_k127_1332988_1	234267.Acid_7827	5.693e-176	560.0	COG1085@1|root,COG1085@2|Bacteria,3Y3TR@57723|Acidobacteria	57723|Acidobacteria	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HFD1_k127_1332988_2	234267.Acid_7123	1.708e-164	530.0	COG0438@1|root,COG0438@2|Bacteria,3Y867@57723|Acidobacteria	57723|Acidobacteria	H	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_1332988_3	234267.Acid_7122	2.279e-155	503.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7122|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1334521_0	401053.AciPR4_2317	2.536e-139	471.0	COG2132@1|root,COG2132@2|Bacteria,3Y65V@57723|Acidobacteria,2JMCT@204432|Acidobacteriia	204432|Acidobacteriia	Q	PFAM multicopper oxidase type 2	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HFD1_k127_1334521_2	1220534.B655_1034	1.026e-56	224.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_1334521_4	1267534.KB906754_gene3628	3.08e-05	57.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_1334521_3	1267535.KB906767_gene429	4.459e-06	60.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y62Q@57723|Acidobacteria,2JM1D@204432|Acidobacteriia	204432|Acidobacteriia	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HFD1_k127_1334521_1	234267.Acid_5051	1.774e-106	349.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_133525_0	234267.Acid_3699	2.238e-163	520.0	COG2355@1|root,COG2355@2|Bacteria,3Y7FK@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_133525_5	1121957.ATVL01000009_gene1279	2.956e-08	61.0	COG1621@1|root,COG1621@2|Bacteria,4NI6T@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_32N,Glyco_hydro_43
HFD1_k127_133525_2	382464.ABSI01000007_gene4163	1.923e-80	278.0	COG1621@1|root,COG3940@1|root,COG1621@2|Bacteria,COG3940@2|Bacteria,46UUU@74201|Verrucomicrobia,2IVAQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_133525_1	1123242.JH636436_gene641	2.06e-131	438.0	COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_133525_4	1123257.AUFV01000009_gene2305	4.491e-15	84.0	COG0500@1|root,COG2226@2|Bacteria,1NDW0@1224|Proteobacteria,1T5AQ@1236|Gammaproteobacteria,1X935@135614|Xanthomonadales	135614|Xanthomonadales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_1337070_0	234267.Acid_0926	3.957e-102	340.0	COG1473@1|root,COG1473@2|Bacteria	2|Bacteria	S	N-acetyldiaminopimelate deacetylase activity	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_1337070_1	1267533.KB906734_gene3779	6.588e-86	294.0	2CEJ5@1|root,2Z7RK@2|Bacteria,3Y4QU@57723|Acidobacteria,2JJMA@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1354261_7	1340493.JNIF01000003_gene2330	3.787e-88	306.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	ubiG	-	2.1.1.222,2.1.1.294,2.1.1.64,2.7.1.181	ko:K00568,ko:K18827	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781,R10657,R10658	RC00002,RC00003,RC00078,RC00392,RC01895,RC03220	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD1_k127_1354261_3	234267.Acid_1371	1.169e-172	545.0	COG0451@1|root,COG0451@2|Bacteria,3Y3T4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD1_k127_1354261_2	234267.Acid_1372	0.0	1012.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD1_k127_1354261_12	234267.Acid_1780	2.125e-27	115.0	2C7DG@1|root,2ZTXV@2|Bacteria,3Y94Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1354261_16	1236497.BAJQ01000003_gene888	1.351e-06	52.0	COG3325@1|root,COG3325@2|Bacteria,4PKZ9@976|Bacteroidetes,2G08M@200643|Bacteroidia	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,Glyco_hydro_18
HFD1_k127_1354261_11	1382359.JIAL01000001_gene178	1.012e-28	119.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD1_k127_1354261_0	1123511.KB905839_gene523	0.0	1133.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,4H78T@909932|Negativicutes	909932|Negativicutes	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
HFD1_k127_1354261_10	761193.Runsl_0449	4.286e-39	155.0	COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,47P6A@768503|Cytophagia	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
HFD1_k127_1354261_5	525904.Tter_2344	7.791e-149	494.0	COG1472@1|root,COG1472@2|Bacteria,2NQT7@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 3 C-terminal domain	bgxA	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Glyco_hydro_3,Glyco_hydro_3_C
HFD1_k127_1354261_4	756272.Plabr_2687	5.068e-160	515.0	COG3119@1|root,COG3119@2|Bacteria,2J26D@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
HFD1_k127_1354261_1	234267.Acid_6872	0.0	1079.0	2CCP0@1|root,2Z7XN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_1354261_8	1340493.JNIF01000003_gene2289	7.01e-55	213.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_1354261_9	1150469.RSPPHO_02202	2.951e-44	179.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2JYV7@204441|Rhodospirillales	204441|Rhodospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_1354261_6	1340493.JNIF01000003_gene2292	9.395e-109	369.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	3.4.21.62	ko:K01342,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_C2,Peptidase_S8
HFD1_k127_1355316_9	935565.JAEM01000014_gene1742	4.264e-27	121.0	COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,2U6A9@28211|Alphaproteobacteria,2PW7N@265|Paracoccus	28211|Alphaproteobacteria	K	FCD	matR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD1_k127_1355316_2	333138.LQ50_14040	2.525e-152	499.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAXK@1386|Bacillus	91061|Bacilli	C	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD1_k127_1355316_4	1007105.PT7_1582	4.421e-98	333.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VR0V@28216|Betaproteobacteria,3T417@506|Alcaligenaceae	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HFD1_k127_1355316_8	469383.Cwoe_5004	1.318e-50	187.0	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HFD1_k127_1355316_6	1484158.PSNIH1_02095	1.91e-58	215.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1SYGG@1236|Gammaproteobacteria,3VZ1P@53335|Pantoea	1236|Gammaproteobacteria	C	Catalyzes the reduction of tatronate semialdehyde to D- glycerate	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
HFD1_k127_1355316_1	1340493.JNIF01000003_gene3565	4.393e-257	833.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1355316_7	518766.Rmar_1391	1.127e-55	205.0	COG0684@1|root,COG0684@2|Bacteria	2|Bacteria	H	ribonuclease inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD1_k127_1355316_0	452637.Oter_0134	5.761e-317	979.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase,DUF4038,DUF5060,Glyco_hydro_115
HFD1_k127_1355316_5	1305836.AXVE01000011_gene1076	4.505e-59	209.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4HGXD@91061|Bacilli,26EUD@186818|Planococcaceae	91061|Bacilli	G	Ribose 5-phosphate isomerase	lacA	-	5.3.1.26,5.3.1.6	ko:K01808,ko:K01819	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD1_k127_1355316_3	234267.Acid_0673	1.123e-109	368.0	COG2271@1|root,COG2271@2|Bacteria,3Y3W5@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_1356526_1	234267.Acid_7563	2.068e-132	430.0	COG0577@1|root,COG0577@2|Bacteria,3Y64Z@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1356526_2	1267535.KB906767_gene2989	1.678e-52	186.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_1356526_0	234267.Acid_1818	1.321e-187	594.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD1_k127_1358595_1	1137271.AZUM01000011_gene1837	7.366e-39	150.0	COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4E613@85010|Pseudonocardiales	201174|Actinobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
HFD1_k127_1358595_0	1382359.JIAL01000001_gene657	2.654e-223	696.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD1_k127_1365038_7	234267.Acid_5093	3.219e-70	238.0	COG0099@1|root,COG0099@2|Bacteria,3Y4KC@57723|Acidobacteria	57723|Acidobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HFD1_k127_1365038_6	234267.Acid_5092	9.348e-74	249.0	COG0100@1|root,COG0100@2|Bacteria,3Y4BS@57723|Acidobacteria	57723|Acidobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HFD1_k127_1365038_3	234267.Acid_5091	5.973e-116	375.0	COG0522@1|root,COG0522@2|Bacteria,3Y2I1@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HFD1_k127_1365038_1	234267.Acid_5090	1.009e-203	636.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HFD1_k127_1365038_8	234267.Acid_5089	3.711e-70	239.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HFD1_k127_1365038_0	234267.Acid_5088	8.764e-282	871.0	COG1012@1|root,COG1012@2|Bacteria,3Y3CY@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_1365038_5	234267.Acid_5086	4.287e-93	313.0	COG2197@1|root,COG2197@2|Bacteria,3Y59X@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_1365038_2	234267.Acid_5085	1.179e-186	616.0	COG4191@1|root,COG4191@2|Bacteria,3Y499@57723|Acidobacteria	57723|Acidobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_8
HFD1_k127_1365038_9	1267535.KB906767_gene3869	3.844e-42	172.0	COG3637@1|root,COG3637@2|Bacteria,3Y783@57723|Acidobacteria	57723|Acidobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HFD1_k127_1365038_4	234267.Acid_1109	1.306e-94	322.0	COG2982@1|root,COG2982@2|Bacteria,3Y4F7@57723|Acidobacteria	57723|Acidobacteria	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HFD1_k127_1368516_0	1242864.D187_008797	4.709e-38	150.0	COG4643@1|root,COG4643@2|Bacteria,1NUZ8@1224|Proteobacteria,42QV9@68525|delta/epsilon subdivisions,2WN6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3987
HFD1_k127_1372237_13	234267.Acid_6719	4.858e-38	148.0	COG1228@1|root,COG1228@2|Bacteria,3Y6WV@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_1372237_2	234267.Acid_6720	7.744e-217	696.0	COG1228@1|root,COG1228@2|Bacteria,3Y6Y2@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_1372237_4	234267.Acid_6721	1.454e-172	574.0	COG1228@1|root,COG1228@2|Bacteria,3Y6JN@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_1372237_7	1340493.JNIF01000003_gene3002	3.938e-102	353.0	COG1228@1|root,COG1228@2|Bacteria,3Y6WV@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_1372237_17	102232.GLO73106DRAFT_00030090	2.867e-06	58.0	COG3386@1|root,COG3386@2|Bacteria,1G8GY@1117|Cyanobacteria	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1372237_6	156889.Mmc1_2953	1.362e-124	428.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	barA_3	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
HFD1_k127_1372237_10	883080.HMPREF9697_02846	1.224e-51	188.0	COG1898@1|root,COG1898@2|Bacteria,1NCF0@1224|Proteobacteria,2UG3Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD1_k127_1372237_9	883080.HMPREF9697_02847	1.183e-63	235.0	COG2301@1|root,COG2301@2|Bacteria,1RJQ8@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD1_k127_1372237_15	395964.KE386496_gene1251	1.323e-15	89.0	2F5D3@1|root,33XZ2@2|Bacteria	2|Bacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
HFD1_k127_1372237_8	234267.Acid_5432	5.179e-77	261.0	COG2606@1|root,COG2606@2|Bacteria,3Y4MI@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD1_k127_1372237_3	234267.Acid_3346	4.922e-185	608.0	COG1312@1|root,COG1312@2|Bacteria,3Y6WX@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HFD1_k127_1372237_11	639030.JHVA01000001_gene2227	5.552e-46	190.0	COG3040@1|root,COG3040@2|Bacteria,3Y8AV@57723|Acidobacteria,2JN5H@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipocalin / cytosolic fatty-acid binding protein family	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HFD1_k127_1372237_1	234267.Acid_1388	1.666e-225	714.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HFD1_k127_1372237_0	234267.Acid_3368	8.597e-248	806.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y6I3@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1372237_5	234267.Acid_7008	8.34e-170	544.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1372237_12	234267.Acid_0699	1.174e-42	164.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_1372237_14	234267.Acid_2743	2.431e-30	129.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	234267.Acid_2743|-	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_13767_0	861299.J421_0588	1.846e-235	741.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_1377410_0	867903.ThesuDRAFT_00242	1.398e-97	348.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WCC9@538999|Clostridiales incertae sedis	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
HFD1_k127_1377410_1	1459636.NTE_02743	3.602e-07	64.0	COG3391@1|root,arCOG02562@2157|Archaea,41T9S@651137|Thaumarchaeota	651137|Thaumarchaeota	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_1378214_0	1112214.AHIS01000017_gene1331	2.518e-59	209.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria,2K2EB@204457|Sphingomonadales	204457|Sphingomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
HFD1_k127_1378214_1	1121930.AQXG01000002_gene2211	1.405e-10	67.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_1389271_2	234267.Acid_6068	3.887e-23	100.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2,Pkinase_Tyr
HFD1_k127_1389271_0	670307.HYPDE_33213	1.606e-117	394.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
HFD1_k127_1389271_1	234267.Acid_0921	1.906e-76	259.0	COG3581@1|root,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1391830_1	234267.Acid_4046	3.815e-108	358.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_4046|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1391830_0	1123371.ATXH01000004_gene1735	3.977e-234	777.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HFD1_k127_1391830_2	1125701.HMPREF1221_01616	5.429e-39	162.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1391830_4	314230.DSM3645_19358	1.151e-11	68.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
HFD1_k127_1391830_6	452637.Oter_4302	0.0001207	47.0	2DH0V@1|root,2ZY0A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1391830_5	1144275.COCOR_01812	4.448e-07	58.0	COG1680@1|root,COG1680@2|Bacteria,1RGG3@1224|Proteobacteria	1224|Proteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_1393915_0	234267.Acid_3324	0.0	1045.0	COG0457@1|root,COG0457@2|Bacteria,3Y7CG@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_1393915_1	234267.Acid_3323	6.761e-207	655.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1393915_2	234267.Acid_3323	1.183e-186	599.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1393915_3	234267.Acid_3321	3.043e-53	192.0	2CB8T@1|root,349A2@2|Bacteria,3Y8JH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
HFD1_k127_1404064_6	1121920.AUAU01000033_gene2765	4.68e-54	197.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,3Y6AK@57723|Acidobacteria	57723|Acidobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_1404064_0	1242864.D187_009431	3.801e-226	725.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,438BQ@68525|delta/epsilon subdivisions,2X3M4@28221|Deltaproteobacteria,2YWGW@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
HFD1_k127_1404064_5	234267.Acid_5266	1.286e-78	271.0	COG1839@1|root,COG1839@2|Bacteria,3Y7IR@57723|Acidobacteria	57723|Acidobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HFD1_k127_1404064_4	666685.R2APBS1_0457	8.117e-87	304.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,1S9D7@1236|Gammaproteobacteria,1X46I@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD1_k127_1404064_3	234267.Acid_3710	6.695e-101	335.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_1404064_1	234267.Acid_3332	1.442e-180	569.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD1_k127_1404064_2	234267.Acid_3333	2.882e-166	533.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	OmpA,PD40,PI-PLC-X,Pectate_lyase22,TIR_2
HFD1_k127_140481_4	234267.Acid_2396	2.154e-78	268.0	COG0652@1|root,COG0652@2|Bacteria,3Y7SZ@57723|Acidobacteria	57723|Acidobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
HFD1_k127_140481_5	663610.JQKO01000009_gene391	3.023e-45	172.0	COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,2U2GH@28211|Alphaproteobacteria,3NC2E@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD1_k127_140481_0	234267.Acid_2395	0.0	1878.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria	57723|Acidobacteria	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD1_k127_140481_2	234267.Acid_2394	3.346e-215	671.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria	57723|Acidobacteria	EF	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD1_k127_140481_6	315750.BPUM_1561	2.762e-44	172.0	COG3934@1|root,COG3934@2|Bacteria,1V19K@1239|Firmicutes,4HT58@91061|Bacilli,1ZDQE@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase
HFD1_k127_140481_3	234267.Acid_3936	2.634e-193	610.0	COG0191@1|root,COG0191@2|Bacteria,3Y5I1@57723|Acidobacteria	57723|Acidobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HFD1_k127_140481_1	234267.Acid_3937	4.354e-222	694.0	COG0033@1|root,COG0033@2|Bacteria,3Y6EH@57723|Acidobacteria	57723|Acidobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD1_k127_1438513_0	1267535.KB906767_gene1533	1.966e-53	196.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_1438513_1	716928.AJQT01000006_gene2816	3.774e-51	182.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2U73S@28211|Alphaproteobacteria,4BDZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_1438513_3	1366050.N234_23380	1.038e-09	60.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2W0C7@28216|Betaproteobacteria,1KD98@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_1452859_5	234267.Acid_6845	7e-48	179.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria,3Y83C@57723|Acidobacteria	57723|Acidobacteria	I	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD1_k127_1452859_1	234267.Acid_7530	4.541e-85	285.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,3Y3D5@57723|Acidobacteria	57723|Acidobacteria	K	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
HFD1_k127_1452859_3	234267.Acid_7529	1.462e-58	207.0	COG2335@1|root,COG2335@2|Bacteria,3Y7GT@57723|Acidobacteria	2|Bacteria	M	PFAM beta-Ig-H3 fasciclin	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HFD1_k127_1452859_2	1267535.KB906767_gene3386	4.996e-72	259.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_1452859_4	234267.Acid_5474	1.537e-48	177.0	COG4276@1|root,COG4276@2|Bacteria,3Y57N@57723|Acidobacteria	57723|Acidobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD1_k127_1452859_0	1340493.JNIF01000003_gene3565	1.37e-245	775.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_1458677_2	886293.Sinac_3110	5.775e-93	313.0	COG3832@1|root,COG3832@2|Bacteria,2J27S@203682|Planctomycetes	203682|Planctomycetes	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1458677_3	448385.sce2340	2.094e-76	260.0	COG0640@1|root,COG0640@2|Bacteria,1RCIH@1224|Proteobacteria	1224|Proteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_1458677_1	234267.Acid_5013	5.175e-264	820.0	COG2192@1|root,COG2192@2|Bacteria,3Y6AX@57723|Acidobacteria	57723|Acidobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD1_k127_1458677_0	234267.Acid_5012	2.373e-298	918.0	COG0008@1|root,COG0008@2|Bacteria,3Y7DS@57723|Acidobacteria	57723|Acidobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	-	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HFD1_k127_1461944_3	1479238.JQMZ01000001_gene1771	1.448e-101	343.0	COG1629@1|root,COG4771@2|Bacteria,1R4PY@1224|Proteobacteria,2U3FF@28211|Alphaproteobacteria,43ZA5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD1_k127_1461944_2	1267535.KB906767_gene4612	2.268e-210	681.0	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4612|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1461944_0	234267.Acid_2696	1.702e-237	776.0	COG0726@1|root,COG3227@1|root,COG3386@1|root,COG4719@1|root,COG0726@2|Bacteria,COG3227@2|Bacteria,COG3386@2|Bacteria,COG4719@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K14274,ko:K20274	ko00040,ko02024,map00040,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002	-	-	-	CarboxypepD_reg,DUF11,DUF5122,FTP,He_PIG,NHL,Peptidase_M36,SGL
HFD1_k127_1461944_1	1267535.KB906767_gene2867	7.601e-237	754.0	COG0022@1|root,COG0022@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	2|Bacteria	C	Dehydrogenase E1 component	CP_0743	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD1_k127_1461944_5	234267.Acid_2922	8.848e-45	171.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria	57723|Acidobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HFD1_k127_1461944_6	1267535.KB906767_gene767	7.626e-36	144.0	COG4309@1|root,COG4309@2|Bacteria	2|Bacteria	D	conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HFD1_k127_1461944_8	374847.Kcr_0772	0.0002559	46.0	COG0535@1|root,arCOG00938@2157|Archaea	374847.Kcr_0772|-	P	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1461944_7	234267.Acid_2931	8.906e-22	100.0	COG0535@1|root,COG0535@2|Bacteria,3Y2KT@57723|Acidobacteria	57723|Acidobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HFD1_k127_1462761_1	234267.Acid_5431	4.365e-174	555.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_1462761_0	234267.Acid_5430	0.0	1041.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y6TN@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_1464818_6	234267.Acid_5112	6.363e-21	91.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria	57723|Acidobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD1_k127_1464818_4	234267.Acid_5113	6.367e-55	194.0	COG0091@1|root,COG0091@2|Bacteria,3Y4KH@57723|Acidobacteria	57723|Acidobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD1_k127_1464818_3	234267.Acid_5114	4.788e-55	193.0	COG0185@1|root,COG0185@2|Bacteria,3Y560@57723|Acidobacteria	57723|Acidobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD1_k127_1464818_0	234267.Acid_5115	1.968e-158	501.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD1_k127_1464818_5	234267.Acid_5116	4.042e-38	154.0	COG0089@1|root,COG0089@2|Bacteria,3Y58W@57723|Acidobacteria	57723|Acidobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD1_k127_1464818_1	234267.Acid_5117	2.986e-112	371.0	COG0088@1|root,COG0088@2|Bacteria,3Y2PM@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD1_k127_1464818_2	234267.Acid_5118	9.504e-72	243.0	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HFD1_k127_1465059_1	1267535.KB906768_gene5536	4.043e-35	136.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
HFD1_k127_1465059_3	1198114.AciX9_1008	4.617e-13	76.0	COG3440@1|root,COG3440@2|Bacteria	2|Bacteria	V	regulation of methylation-dependent chromatin silencing	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
HFD1_k127_1465059_2	1123288.SOV_1c07280	1.856e-20	108.0	COG0500@1|root,COG2226@2|Bacteria,1V7SG@1239|Firmicutes	1239|Firmicutes	Q	ubiE/COQ5 methyltransferase family	yxbB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD1_k127_1465059_0	344747.PM8797T_28904	1.378e-284	909.0	COG1520@1|root,COG1957@1|root,COG1520@2|Bacteria,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,DUF547,PQQ_2,PQQ_3
HFD1_k127_1515089_5	251221.35211765	3.83e-171	566.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_1515089_14	69395.JQLZ01000005_gene3678	5.012e-53	191.0	COG3832@1|root,COG3832@2|Bacteria,1RJJY@1224|Proteobacteria,2U9FZ@28211|Alphaproteobacteria,2KIZS@204458|Caulobacterales	204458|Caulobacterales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_1515089_21	234267.Acid_1917	9.333e-40	157.0	COG0640@1|root,COG0640@2|Bacteria,3Y5C4@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_1515089_0	234267.Acid_2425	0.0	1128.0	COG0577@1|root,COG0577@2|Bacteria,3Y3JP@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1515089_20	43989.cce_0328	2.522e-41	174.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K12685,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko02000,ko02044	1.B.12.5.1,1.B.12.5.3	-	-	Autotransporter,DUF4114,PATR,Peptidase_S8
HFD1_k127_1515089_8	234267.Acid_1068	2.453e-113	370.0	COG2264@1|root,COG2264@2|Bacteria,3Y5SG@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HFD1_k127_1515089_7	234267.Acid_1067	9.976e-158	515.0	COG0329@1|root,COG0329@2|Bacteria,3Y30K@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
HFD1_k127_1515089_4	234267.Acid_1531	1.612e-182	586.0	COG0728@1|root,COG0728@2|Bacteria,3Y6N1@57723|Acidobacteria	57723|Acidobacteria	S	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD1_k127_1515089_2	234267.Acid_1530	1.038e-201	631.0	COG0473@1|root,COG0473@2|Bacteria,3Y77P@57723|Acidobacteria	57723|Acidobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
HFD1_k127_1515089_11	234267.Acid_5767	9.234e-74	256.0	2C730@1|root,32UQY@2|Bacteria,3Y59Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1515089_1	234267.Acid_2022	1.695e-246	767.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria	57723|Acidobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD1_k127_1515089_12	234267.Acid_2021	2.069e-69	237.0	2BXJ8@1|root,342E7@2|Bacteria,3Y87K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1515089_22	234267.Acid_0964	1.826e-32	131.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
HFD1_k127_1515089_10	234267.Acid_0965	3.636e-78	265.0	COG2137@1|root,COG2137@2|Bacteria,3Y4WT@57723|Acidobacteria	57723|Acidobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HFD1_k127_1515089_16	234267.Acid_1152	1.27e-46	170.0	COG0346@1|root,COG0346@2|Bacteria,3Y8F5@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_1515089_17	234267.Acid_1703	1.369e-45	171.0	2DMJE@1|root,32RYR@2|Bacteria,3Y4XN@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HFD1_k127_1515089_6	497964.CfE428DRAFT_1242	3.79e-160	517.0	COG0823@1|root,COG0823@2|Bacteria,46SJJ@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1515089_9	234267.Acid_4847	4.223e-81	290.0	COG5434@1|root,COG5434@2|Bacteria,3Y2SR@57723|Acidobacteria	57723|Acidobacteria	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
HFD1_k127_1515089_19	1267533.KB906733_gene3450	1.929e-44	168.0	COG3685@1|root,COG3685@2|Bacteria,3Y534@57723|Acidobacteria,2JJHZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
HFD1_k127_1515089_3	1267535.KB906767_gene3348	1.072e-197	621.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia	204432|Acidobacteriia	C	Delta-1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD1_k127_1551594_0	234267.Acid_6438	0.0	1186.0	COG1572@1|root,COG2304@1|root,COG5426@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6YC@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HFD1_k127_1551594_1	929556.Solca_2680	1.006e-40	165.0	COG2885@1|root,COG2885@2|Bacteria,4NI3U@976|Bacteroidetes,1IQ3S@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl_2,OmpA
HFD1_k127_1555198_10	1121033.AUCF01000004_gene4677	4.071e-43	170.0	COG3093@1|root,COG3093@2|Bacteria,1MV9M@1224|Proteobacteria,2U2WE@28211|Alphaproteobacteria,2JUN8@204441|Rhodospirillales	204441|Rhodospirillales	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD1_k127_1555198_11	1123371.ATXH01000020_gene496	3.317e-05	47.0	COG3093@1|root,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD1_k127_1555198_4	401053.AciPR4_2771	1.71e-116	381.0	COG3279@1|root,COG3279@2|Bacteria,3Y4VI@57723|Acidobacteria,2JJIJ@204432|Acidobacteriia	204432|Acidobacteriia	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD1_k127_1555198_3	401053.AciPR4_2770	2.485e-145	470.0	COG2972@1|root,COG2972@2|Bacteria,3Y4VK@57723|Acidobacteria,2JP3H@204432|Acidobacteriia	204432|Acidobacteriia	T	histidine kinase internal region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HFD1_k127_1555198_1	234267.Acid_1463	1.468e-212	664.0	2DBYN@1|root,2ZBWH@2|Bacteria,3Y43H@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1555198_2	234267.Acid_0695	1.816e-154	506.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_1555198_6	1235279.C772_00848	5.506e-82	282.0	COG0654@1|root,COG0654@2|Bacteria,1VB0I@1239|Firmicutes,4HNE5@91061|Bacilli,26G40@186818|Planococcaceae	91061|Bacilli	CH	FAD binding domain	-	-	1.14.13.24	ko:K22270	ko00362,ko01120,map00362,map01120	-	R02589	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD1_k127_1555198_8	333138.LQ50_02420	1.502e-60	228.0	COG0654@1|root,COG0654@2|Bacteria,1U29G@1239|Firmicutes,4HF0P@91061|Bacilli,1ZE9I@1386|Bacillus	91061|Bacilli	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD1_k127_1555198_0	234267.Acid_1017	1.433e-233	729.0	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD1_k127_1555198_9	234267.Acid_1016	6.622e-54	194.0	2DNWY@1|root,32UJU@2|Bacteria,3Y584@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2393)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2393
HFD1_k127_1555198_5	1267534.KB906754_gene3556	1.574e-92	311.0	COG1741@1|root,COG1741@2|Bacteria,3Y4JD@57723|Acidobacteria,2JMPB@204432|Acidobacteriia	204432|Acidobacteriia	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD1_k127_1555198_7	234267.Acid_1890	1.394e-60	210.0	COG4178@1|root,COG4178@2|Bacteria	2|Bacteria	P	(ABC) transporter	-	-	-	ko:K02021,ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.203.11,3.A.1.203.4,3.A.1.21	-	-	ABC_membrane_2,ABC_tran
HFD1_k127_1572874_1	234267.Acid_6386	1.269e-152	492.0	COG2159@1|root,COG2159@2|Bacteria,3Y2PY@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_1572874_0	234267.Acid_6385	3.89e-213	671.0	COG0405@1|root,COG0405@2|Bacteria,3Y2I7@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD1_k127_158971_2	1123242.JH636434_gene3999	5.889e-148	486.0	COG5337@1|root,COG5337@2|Bacteria,2IYR8@203682|Planctomycetes	203682|Planctomycetes	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
HFD1_k127_158971_7	497964.CfE428DRAFT_4052	4.939e-42	160.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_158971_6	234267.Acid_1095	1.176e-48	183.0	COG5662@1|root,COG5662@2|Bacteria,3Y511@57723|Acidobacteria	57723|Acidobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD1_k127_158971_8	1040983.AXAE01000005_gene1466	1.08e-33	141.0	COG3153@1|root,COG3153@2|Bacteria,1QY69@1224|Proteobacteria,2VGFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_158971_5	172088.AUGA01000016_gene2419	4.974e-86	292.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,3K3NP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HFD1_k127_158971_4	234267.Acid_5127	2.365e-120	401.0	COG0671@1|root,COG0671@2|Bacteria,3Y7V9@57723|Acidobacteria	57723|Acidobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD1_k127_158971_3	234267.Acid_1096	3.171e-137	450.0	COG1409@1|root,COG1409@2|Bacteria,3Y3P7@57723|Acidobacteria	57723|Acidobacteria	C	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_158971_9	639030.JHVA01000001_gene2301	1.257e-21	108.0	COG3474@1|root,COG3474@2|Bacteria,3Y5RW@57723|Acidobacteria,2JM2Y@204432|Acidobacteriia	204432|Acidobacteriia	C	Haem-binding domain	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Haem_bd
HFD1_k127_158971_1	234267.Acid_2400	4.764e-193	609.0	COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria	57723|Acidobacteria	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD1_k127_158971_0	234267.Acid_2399	0.0	1110.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,3Y343@57723|Acidobacteria	57723|Acidobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HFD1_k127_1610944_13	234267.Acid_5249	8.329e-70	252.0	COG4254@1|root,COG4254@2|Bacteria,3Y58Q@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD1_k127_1610944_2	234267.Acid_5250	2.874e-156	497.0	COG0152@1|root,COG0152@2|Bacteria,3Y2KX@57723|Acidobacteria	57723|Acidobacteria	F	PFAM SAICAR synthetase	purC	-	6.3.2.6,6.3.4.13	ko:K01923,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD1_k127_1610944_14	234267.Acid_5251	2.849e-66	240.0	COG1286@1|root,COG1286@2|Bacteria,3Y8DX@57723|Acidobacteria	57723|Acidobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HFD1_k127_1610944_19	946235.CAER01000041_gene2135	3.929e-08	59.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,23IJJ@182709|Oceanobacillus	91061|Bacilli	KT	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HFD1_k127_1610944_6	234267.Acid_5253	3.44e-105	349.0	COG0546@1|root,COG0546@2|Bacteria,3Y4RC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD1_k127_1610944_8	234267.Acid_5255	3.823e-101	335.0	2B11W@1|root,31TFA@2|Bacteria,3Y4Z8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1610944_15	234267.Acid_5256	8.964e-65	227.0	COG2318@1|root,COG2318@2|Bacteria,3Y4TA@57723|Acidobacteria	57723|Acidobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_1610944_1	234267.Acid_5257	5.76e-180	574.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD1_k127_1610944_17	234267.Acid_5258	1.72e-40	152.0	COG2010@1|root,COG2010@2|Bacteria,3Y5PY@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_1610944_7	234267.Acid_5285	5.193e-104	346.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HFD1_k127_1610944_3	234267.Acid_5288	1.606e-143	471.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_5288|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1610944_5	234267.Acid_5289	4.633e-109	356.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria	57723|Acidobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD1_k127_1610944_4	234267.Acid_7914	2.809e-128	421.0	COG0457@1|root,COG0457@2|Bacteria,3Y7TN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1610944_10	1340493.JNIF01000003_gene2136	7.871e-99	352.0	COG1028@1|root,COG1028@2|Bacteria,3Y2YB@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_1610944_0	234267.Acid_6668	1.537e-301	932.0	COG3250@1|root,COG3250@2|Bacteria,3Y48R@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C
HFD1_k127_1610944_12	1047013.AQSP01000125_gene2637	1.332e-74	276.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
HFD1_k127_1610944_11	234267.Acid_4320	3.157e-81	282.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_1610944_9	234267.Acid_4321	2.065e-99	343.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_1611567_0	234267.Acid_1741	2.014e-172	547.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD1_k127_1611567_1	344747.PM8797T_06847	3e-74	260.0	COG0657@1|root,COG3458@1|root,COG0657@2|Bacteria,COG3458@2|Bacteria,2J1TC@203682|Planctomycetes	203682|Planctomycetes	Q	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1629540_0	234267.Acid_4006	3.994e-220	691.0	COG3119@1|root,COG3119@2|Bacteria,3Y5BX@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_1629540_2	234267.Acid_2297	2.304e-50	188.0	COG0768@1|root,COG0768@2|Bacteria,3Y5NC@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin binding protein transpeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HFD1_k127_1629540_1	234267.Acid_2298	5.864e-132	442.0	COG2385@1|root,COG2385@2|Bacteria,3Y370@57723|Acidobacteria	57723|Acidobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SPOR,SpoIID
HFD1_k127_1633772_0	1210884.HG799468_gene13872	9.881e-89	308.0	28MWI@1|root,2ZB3T@2|Bacteria	2|Bacteria	S	Plasmid encoded RepA protein	repA	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	RepA_C
HFD1_k127_1633772_1	105559.Nwat_3194	2e-09	64.0	2ETNN@1|root,33M6D@2|Bacteria,1NHR1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1636514_2	1267535.KB906767_gene3668	5.994e-99	340.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_1636514_6	682795.AciX8_2515	3.275e-43	161.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_1636514_4	234267.Acid_3880	1.758e-59	209.0	COG1225@1|root,COG1225@2|Bacteria,3Y8N3@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_1636514_3	234267.Acid_3879	7.507e-86	288.0	COG1143@1|root,COG1143@2|Bacteria,3Y371@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HFD1_k127_1636514_1	234267.Acid_3878	2.865e-104	351.0	COG1045@1|root,COG1045@2|Bacteria,3Y4HF@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HFD1_k127_1636514_5	234267.Acid_3876	7.497e-49	178.0	COG5507@1|root,COG5507@2|Bacteria,3Y82V@57723|Acidobacteria	57723|Acidobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD1_k127_1636514_0	234267.Acid_3875	6.117e-272	844.0	COG4799@1|root,COG4799@2|Bacteria,3Y3DC@57723|Acidobacteria	57723|Acidobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD1_k127_1637532_0	234267.Acid_5423	3.844e-303	938.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y4NM@57723|Acidobacteria	57723|Acidobacteria	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HFD1_k127_1637532_1	234267.Acid_5424	1.831e-90	308.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
HFD1_k127_1638830_2	234267.Acid_6640	3.011e-226	707.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02584,ko:K07713,ko:K15836,ko:K21009	ko02020,ko02025,map02020,map02025	M00499	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	GAF,GAF_2,HTH_8,PocR,Sigma54_activat,Yop-YscD_cpl
HFD1_k127_1638830_0	234267.Acid_6424	0.0	1069.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria	57723|Acidobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HFD1_k127_1638830_6	485913.Krac_9228	4.096e-88	297.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD1_k127_1638830_7	485913.Krac_9227	2.514e-75	260.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD1_k127_1638830_9	234267.Acid_6689	1.472e-55	209.0	COG2062@1|root,COG2062@2|Bacteria,3Y5YQ@57723|Acidobacteria	57723|Acidobacteria	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD1_k127_1638830_1	234267.Acid_6691	1.687e-270	837.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD1_k127_1638830_5	251221.35211765	7.993e-114	395.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_1638830_3	234267.Acid_4086	4.884e-226	711.0	COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria	57723|Acidobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
HFD1_k127_1638830_4	234267.Acid_7201	1.397e-219	693.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_1638830_8	234267.Acid_7200	1.079e-61	216.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD1_k127_1644521_5	234267.Acid_3937	1.78e-64	223.0	COG0033@1|root,COG0033@2|Bacteria,3Y6EH@57723|Acidobacteria	57723|Acidobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD1_k127_1644521_0	234267.Acid_3939	8.111e-123	399.0	COG0053@1|root,COG0053@2|Bacteria,3Y43E@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD1_k127_1644521_3	713587.THITH_12520	4.313e-116	386.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_1644521_10	234267.Acid_3832	3.644e-40	158.0	2CIIF@1|root,30NI8@2|Bacteria,3Y8FJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1644521_7	234267.Acid_3831	3.777e-46	169.0	2FD54@1|root,3457B@2|Bacteria,3Y8HH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1644521_9	234267.Acid_1394	2.556e-42	160.0	COG2442@1|root,COG2442@2|Bacteria,3Y828@57723|Acidobacteria	57723|Acidobacteria	S	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1644521_4	234267.Acid_1395	1.997e-80	276.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Fer4_15,Patatin
HFD1_k127_1644521_8	234267.Acid_1396	5.489e-43	159.0	2FE1U@1|root,34620@2|Bacteria,3Y8MC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1644521_11	234267.Acid_1397	4.874e-39	148.0	2DF3Q@1|root,2ZQCR@2|Bacteria,3Y8YJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1644521_2	1144275.COCOR_04568	4.442e-117	394.0	COG2234@1|root,COG2234@2|Bacteria,1R77P@1224|Proteobacteria	1224|Proteobacteria	N	Aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_1644521_1	234267.Acid_4392	6.081e-119	389.0	COG0491@1|root,COG0491@2|Bacteria,3Y4D7@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_1644521_12	717231.Flexsi_0373	1.011e-19	94.0	2DMID@1|root,32RSF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii,DUF2204
HFD1_k127_1652604_1	443143.GM18_3568	7.618e-133	432.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKE@68525|delta/epsilon subdivisions,2WJTK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_1652604_0	243231.GSU2781	1.088e-155	499.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria,43TCG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HFD1_k127_1652604_2	243231.GSU2782	1.384e-77	262.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_1653476_1	234267.Acid_0600	1.014e-160	511.0	COG1104@1|root,COG1104@2|Bacteria,3Y389@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_1653476_0	234267.Acid_0599	3.413e-191	606.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD1_k127_1653476_3	1191523.MROS_2048	7.374e-81	292.0	COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH
HFD1_k127_1653476_2	234267.Acid_4307	1.473e-124	405.0	COG0551@1|root,COG0551@2|Bacteria,3Y7FR@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF1595)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD1_k127_1703932_7	234267.Acid_5652	2.482e-46	167.0	COG0437@1|root,COG0437@2|Bacteria,3Y81X@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD1_k127_1703932_1	234267.Acid_5651	7.709e-201	631.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD1_k127_1703932_4	234267.Acid_5650	5.651e-101	354.0	2C6TZ@1|root,32RHS@2|Bacteria,3Y85R@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1703932_13	234267.Acid_7033	0.0004326	53.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD1_k127_1703932_6	234267.Acid_5692	3.699e-98	327.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,DUF4241
HFD1_k127_1703932_5	234267.Acid_4908	1.596e-98	333.0	COG0673@1|root,COG0673@2|Bacteria,3Y6XR@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1703932_3	234267.Acid_4909	2.754e-115	378.0	COG1082@1|root,COG1082@2|Bacteria,3Y72F@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_1703932_10	1121447.JONL01000010_gene2481	8.47e-15	86.0	COG1216@1|root,COG1216@2|Bacteria,1R0WS@1224|Proteobacteria,432DJ@68525|delta/epsilon subdivisions,2WXRB@28221|Deltaproteobacteria,2ME6G@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_1703932_9	344747.PM8797T_03584	1.263e-34	152.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD1_k127_1703932_8	1267535.KB906767_gene3489	1.191e-42	163.0	COG0250@1|root,COG0250@2|Bacteria,3Y83Z@57723|Acidobacteria	57723|Acidobacteria	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
HFD1_k127_1703932_2	234267.Acid_5901	1.501e-120	391.0	COG0450@1|root,COG0450@2|Bacteria,3Y444@57723|Acidobacteria	57723|Acidobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HFD1_k127_1703932_0	234267.Acid_2017	0.0	1292.0	COG1506@1|root,COG1506@2|Bacteria,3Y2HK@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD1_k127_1719169_2	234267.Acid_5310	8.589e-101	329.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_1719169_1	234267.Acid_5311	9.169e-115	375.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1719169_0	1340493.JNIF01000003_gene2854	1.97e-174	557.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1731348_5	234267.Acid_4306	3.572e-52	185.0	COG2960@1|root,COG2960@2|Bacteria,3Y7EA@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD1_k127_1731348_8	861299.J421_0572	8.565e-27	120.0	COG1595@1|root,COG2312@1|root,COG1595@2|Bacteria,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	DUF4157,SatD,Sigma70_r2
HFD1_k127_1731348_1	880073.Calab_1764	1.051e-113	384.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_1731348_4	1411123.JQNH01000001_gene3173	1.01e-86	297.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2U62M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_3
HFD1_k127_1731348_2	234267.Acid_5683	4.076e-96	319.0	COG0852@1|root,COG0852@2|Bacteria,3Y5E8@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD1_k127_1731348_0	234267.Acid_5684	1.32e-229	717.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HFD1_k127_1731348_3	234267.Acid_5685	4.554e-89	294.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HFD1_k127_1731348_7	1267535.KB906767_gene2815	6.598e-46	173.0	COG0839@1|root,COG0839@2|Bacteria,3Y5QU@57723|Acidobacteria,2JNJY@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD1_k127_1731348_6	234267.Acid_5687	1.501e-48	174.0	COG0713@1|root,COG0713@2|Bacteria,3Y54E@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD1_k127_1733974_0	234267.Acid_3518	1.126e-245	769.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD1_k127_1733974_12	1144275.COCOR_07363	3.022e-26	113.0	COG1733@1|root,COG1733@2|Bacteria,1N0WJ@1224|Proteobacteria	1224|Proteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD1_k127_1733974_6	485913.Krac_4367	4.469e-91	305.0	COG1028@1|root,COG1028@2|Bacteria	485913.Krac_4367|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1733974_13	1254432.SCE1572_12835	6.435e-25	106.0	COG5470@1|root,COG5470@2|Bacteria,1N5NR@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HFD1_k127_1733974_4	765869.BDW_13115	1.978e-94	317.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2MSX4@213481|Bdellovibrionales,2WIQK@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD1_k127_1733974_8	907348.TresaDRAFT_2230	2.077e-71	256.0	COG0414@1|root,COG0414@2|Bacteria,2J6UH@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD1_k127_1733974_5	264462.Bd3564	8.522e-93	312.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2MTS4@213481|Bdellovibrionales,2WJ3N@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HFD1_k127_1733974_2	234267.Acid_0782	1.121e-125	413.0	COG0477@1|root,COG2814@2|Bacteria,3Y3E8@57723|Acidobacteria	57723|Acidobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_1733974_1	234267.Acid_0789	6.408e-193	613.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria	57723|Acidobacteria	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD1_k127_1733974_3	234267.Acid_0791	1.038e-97	325.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
HFD1_k127_1733974_9	234267.Acid_0792	1.473e-70	245.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD1_k127_1733974_7	234267.Acid_0793	1.036e-76	259.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_1737300_8	682795.AciX8_4755	1.86e-84	282.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.1.3.1,3.1.3.5,3.6.1.45	ko:K01077,ko:K11751	ko00230,ko00240,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00730,map00760,map00790,map01100,map01110,map02020	M00126	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02135,R02323,R02719,R03346,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Big_2,Cadherin-like,Cu_amine_oxidN1,DUF4430,FIVAR,Flg_new,Prenyltrans,SLH
HFD1_k127_1737300_2	639030.JHVA01000001_gene2315	3.621e-200	636.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
HFD1_k127_1737300_10	234267.Acid_1324	4.186e-52	192.0	COG4219@1|root,COG4219@2|Bacteria,3Y7YA@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_1737300_6	234267.Acid_1900	1.264e-124	406.0	COG3291@1|root,COG3291@2|Bacteria,3Y401@57723|Acidobacteria	57723|Acidobacteria	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_1737300_0	215803.DB30_0565	6.991e-238	755.0	COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria,438V6@68525|delta/epsilon subdivisions,2X414@28221|Deltaproteobacteria,2YXVR@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HFD1_k127_1737300_9	234267.Acid_5427	9.02e-62	216.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	cNMP_binding
HFD1_k127_1737300_3	234267.Acid_5426	3.718e-162	525.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria	2|Bacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD1_k127_1737300_1	234267.Acid_5425	2.84e-230	740.0	COG0427@1|root,COG0427@2|Bacteria,3Y3BI@57723|Acidobacteria	57723|Acidobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HFD1_k127_1737300_7	1120985.AUMI01000002_gene2392	2.676e-86	295.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4H4TK@909932|Negativicutes	909932|Negativicutes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_1737300_4	1382359.JIAL01000001_gene2839	5.868e-162	521.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
HFD1_k127_1737300_5	234267.Acid_1485	4.419e-150	482.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_1739208_4	234267.Acid_7100	8.136e-59	207.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_1739208_1	234267.Acid_0293	9.066e-127	415.0	COG0251@1|root,COG0251@2|Bacteria,3Y810@57723|Acidobacteria	57723|Acidobacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1739208_3	234267.Acid_0292	3.483e-86	300.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0292|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1739208_2	234267.Acid_0292	7.881e-92	315.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0292|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1739208_0	1267535.KB906767_gene821	5.3e-146	480.0	COG1167@1|root,COG1167@2|Bacteria,3Y3WK@57723|Acidobacteria,2JI7P@204432|Acidobacteriia	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD1_k127_1739208_5	234267.Acid_0290	6.729e-21	107.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the PdxS SNZ family	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD1_k127_1743797_4	234267.Acid_0286	4.363e-106	349.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	5.1.3.10,5.1.3.2	ko:K01784,ko:K12454	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984,R04266	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD1_k127_1743797_2	234267.Acid_6299	3.116e-138	444.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD1_k127_1743797_5	234267.Acid_6507	1.384e-50	190.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
HFD1_k127_1743797_3	234267.Acid_6506	1.64e-137	447.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD1_k127_1743797_0	234267.Acid_3953	5.051e-281	877.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_1743797_1	234267.Acid_3952	1.914e-172	544.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_1757790_0	234267.Acid_0690	2.415e-268	828.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria	57723|Acidobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD1_k127_1763599_0	1278309.KB907099_gene2913	3.923e-246	809.0	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1764636_3	394.NGR_c19460	8.247e-06	51.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BAVP@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
HFD1_k127_1764636_0	234267.Acid_1593	0.0	1251.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1593|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1764636_1	661478.OP10G_4632	2.773e-164	542.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD1_k127_1764636_2	234267.Acid_0003	2.668e-77	260.0	COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria	57723|Acidobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD1_k127_1765958_0	234267.Acid_4102	9.17e-104	346.0	COG0845@1|root,COG0845@2|Bacteria,3Y6E7@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1765958_1	234267.Acid_4103	1.553e-86	290.0	COG0845@1|root,COG0845@2|Bacteria,3Y7DU@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
HFD1_k127_1766413_0	234267.Acid_5611	1.532e-264	859.0	COG4934@1|root,COG4934@2|Bacteria,3Y37M@57723|Acidobacteria	57723|Acidobacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Peptidase_S8,Pro-kuma_activ
HFD1_k127_1766413_5	234267.Acid_7367	1.71e-116	381.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_1766413_6	234267.Acid_7366	4.054e-104	347.0	2D61V@1|root,32TKB@2|Bacteria,3Y5CF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1766413_8	234267.Acid_7365	1.571e-36	149.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1766413_7	234267.Acid_7364	5.979e-98	329.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	liaG3	-	-	-	-	-	-	-	-	-	-	-	DUF1700,DUF2807,DUF4097
HFD1_k127_1766413_9	272123.Anacy_4552	1.973e-15	79.0	COG1724@1|root,COG1724@2|Bacteria,1G90Q@1117|Cyanobacteria,1HPX7@1161|Nostocales	1117|Cyanobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_1766413_10	1469607.KK073768_gene3002	8.009e-14	76.0	COG1598@1|root,COG1598@2|Bacteria,1G9G2@1117|Cyanobacteria,1HPZH@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD1_k127_1766413_2	234267.Acid_7363	2.512e-192	607.0	COG3359@1|root,COG3359@2|Bacteria,3Y6WT@57723|Acidobacteria	57723|Acidobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HFD1_k127_1766413_4	234267.Acid_7362	1.204e-160	509.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	2|Bacteria	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0646	NTP_transferase
HFD1_k127_1766413_3	234267.Acid_7361	1.604e-178	574.0	COG1807@1|root,COG1807@2|Bacteria,3Y6PY@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1766413_1	234267.Acid_1177	3.696e-197	617.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HFD1_k127_1778721_4	448385.sce6257	2.473e-35	144.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MWVZ@1224|Proteobacteria,43APJ@68525|delta/epsilon subdivisions,2X638@28221|Deltaproteobacteria,2Z38P@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_1778721_14	234267.Acid_5846	9.581e-11	74.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_1778721_16	234267.Acid_5847	4.184e-06	54.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1778721_12	234267.Acid_4951	1.114e-11	69.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_4951|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1778721_9	234267.Acid_5847	3.035e-23	110.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1778721_0	234267.Acid_2993	0.0	1027.0	COG3507@1|root,COG3507@2|Bacteria,3Y6BR@57723|Acidobacteria	57723|Acidobacteria	G	family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_1778721_15	1156935.QWE_03258	1.797e-10	67.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2U9FS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD1_k127_1778721_10	1173028.ANKO01000020_gene5476	1.34e-17	86.0	COG2442@1|root,COG2442@2|Bacteria,1G9FC@1117|Cyanobacteria,1HDDA@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD1_k127_1778721_6	113355.CM001775_gene2001	1.935e-26	113.0	COG4634@1|root,COG4634@2|Bacteria,1GA41@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1778721_7	479434.Sthe_1907	7.143e-26	124.0	2EX77@1|root,33QI3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1778721_2	1356852.N008_05325	1.141e-111	398.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HFD1_k127_1778721_3	945713.IALB_2758	5.311e-53	202.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_1778721_13	234267.Acid_3528	1.503e-11	75.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD1_k127_1778721_11	351160.RCIX1492	9.87e-15	85.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
HFD1_k127_1778721_1	1122915.AUGY01000026_gene2308	1.279e-143	466.0	COG4289@1|root,COG4289@2|Bacteria,1US9A@1239|Firmicutes,4HFEI@91061|Bacilli,275BK@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterized protein conserved in bacteria (DUF2264)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2264
HFD1_k127_1778721_5	2074.JNYD01000012_gene454	1.617e-29	121.0	COG5646@1|root,COG5646@2|Bacteria,2I3RY@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_1778721_8	1183438.GKIL_4239	1.195e-25	108.0	COG0120@1|root,COG0120@2|Bacteria,1G2DW@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rpiA	Rib_5-P_isom_A
HFD1_k127_1793191_0	278957.ABEA03000120_gene1170	8.681e-226	710.0	COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,3K769@414999|Opitutae	414999|Opitutae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
HFD1_k127_1797148_0	234267.Acid_2975	5.628e-102	362.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_1806977_10	1267535.KB906767_gene1087	4.842e-73	256.0	COG4993@1|root,COG4993@2|Bacteria,3Y6W9@57723|Acidobacteria,2JKUB@204432|Acidobacteriia	204432|Acidobacteriia	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_1806977_9	1267535.KB906767_gene1088	4.444e-73	254.0	COG2010@1|root,COG2010@2|Bacteria,3Y7IS@57723|Acidobacteria,2JMTD@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_1806977_5	658086.HMPREF0994_03992	4.766e-130	448.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4838,F5_F8_type_C,Glyco_hydro_67N
HFD1_k127_1806977_0	234267.Acid_2120	0.0	1566.0	COG1361@1|root,COG1361@2|Bacteria,3Y2G0@57723|Acidobacteria	57723|Acidobacteria	M	Alpha-L-arabinofuranosidase B, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	ArabFuran-catal,LTD,NPCBM_assoc
HFD1_k127_1806977_2	234267.Acid_1851	1.099e-208	667.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
HFD1_k127_1806977_8	204669.Acid345_0475	2.51e-97	334.0	COG2204@1|root,COG2204@2|Bacteria,3Y6FW@57723|Acidobacteria	57723|Acidobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_1806977_6	204669.Acid345_2739	2.399e-129	432.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1806977_16	102125.Xen7305DRAFT_00050810	2.091e-14	82.0	COG0454@1|root,COG0456@2|Bacteria,1GIEU@1117|Cyanobacteria,3VKQD@52604|Pleurocapsales	1117|Cyanobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_1806977_12	1267535.KB906767_gene2664	1.209e-56	205.0	COG4675@1|root,COG4675@2|Bacteria,3Y4U8@57723|Acidobacteria,2JJF5@204432|Acidobacteriia	204432|Acidobacteriia	S	Tail Collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
HFD1_k127_1806977_13	755732.Fluta_0083	2.978e-52	190.0	COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes,1I31T@117743|Flavobacteriia,2PBSF@246874|Cryomorphaceae	976|Bacteroidetes	S	PFAM Phage Tail Collar Domain	-	-	-	-	-	-	-	-	-	-	-	-	Collar
HFD1_k127_1806977_14	278963.ATWD01000001_gene4093	2.852e-29	133.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	bca	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Collagen,Gram_pos_anchor,He_PIG,Rib,YSIRK_signal
HFD1_k127_1806977_17	1385935.N836_16510	9.444e-12	76.0	2E08I@1|root,32VW6@2|Bacteria,1GG02@1117|Cyanobacteria	1117|Cyanobacteria	S	exosortase interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1806977_4	234267.Acid_5141	4.942e-162	556.0	COG4485@1|root,COG4485@2|Bacteria	2|Bacteria	M	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD1_k127_1806977_15	926550.CLDAP_33740	2.075e-26	128.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
HFD1_k127_1806977_7	234267.Acid_1064	2.28e-104	366.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria	57723|Acidobacteria	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1806977_3	234267.Acid_1063	3.648e-194	629.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
HFD1_k127_1806977_11	234267.Acid_1061	2.93e-66	238.0	COG2165@1|root,COG2165@2|Bacteria,3Y4RJ@57723|Acidobacteria	57723|Acidobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HFD1_k127_1806977_1	234267.Acid_1060	1.076e-265	837.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N,TPR_8
HFD1_k127_1809439_1	357808.RoseRS_1575	5.369e-159	516.0	COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi,376Q1@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase, family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD1_k127_1809439_0	420324.KI912022_gene340	0.0	1264.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JT1D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HFD1_k127_1814726_8	234267.Acid_6050	2.83e-16	94.0	2DEJZ@1|root,2ZN9G@2|Bacteria,3Y8Y9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1814726_9	1499683.CCFF01000017_gene2182	5.178e-14	82.0	COG0793@1|root,COG0793@2|Bacteria,1UYV5@1239|Firmicutes,24B0A@186801|Clostridia,36DRS@31979|Clostridiaceae	186801|Clostridia	M	Peptidase, S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD1_k127_1814726_4	234267.Acid_1557	1.028e-79	281.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,TPR_8
HFD1_k127_1814726_11	204669.Acid345_3217	7.76e-06	55.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	MtrB_PioB,OMP_b-brl
HFD1_k127_1814726_3	68219.JNXI01000002_gene3959	8.925e-87	295.0	2EYIJ@1|root,33RSC@2|Bacteria,2IPA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1814726_1	234267.Acid_4061	5.007e-149	489.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,Dala_Dala_lig_C,RimK
HFD1_k127_1814726_0	452637.Oter_3704	1.036e-155	503.0	COG3693@1|root,COG3693@2|Bacteria,46UVW@74201|Verrucomicrobia,3K7XQ@414999|Opitutae	2|Bacteria	G	Beta-xylanase	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_4_9,Glyco_hydro_10
HFD1_k127_1814726_6	595460.RRSWK_01562	8.545e-22	110.0	COG1714@1|root,COG1714@2|Bacteria,2J3VC@203682|Planctomycetes	203682|Planctomycetes	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HFD1_k127_1814726_5	1502851.FG93_03399	2.191e-28	123.0	COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YHS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HFD1_k127_1814726_2	1267533.KB906734_gene3737	1.863e-106	360.0	28JCT@1|root,2Z97C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1814726_10	326427.Cagg_0349	4.448e-08	58.0	COG0664@1|root,COG0664@2|Bacteria,2G6WI@200795|Chloroflexi,377BC@32061|Chloroflexia	32061|Chloroflexia	K	PFAM cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_1823014_1	1267535.KB906767_gene4725	1.654e-199	623.0	COG2133@1|root,COG2133@2|Bacteria,3Y36R@57723|Acidobacteria,2JIPT@204432|Acidobacteriia	204432|Acidobacteriia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_1823014_3	1298593.TOL_1201	5.582e-85	287.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,1S3V3@1236|Gammaproteobacteria,1XJK0@135619|Oceanospirillales	135619|Oceanospirillales	FJ	MafB19-like deaminase	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD1_k127_1823014_2	414684.RC1_3325	1.382e-87	297.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,2JRW2@204441|Rhodospirillales	204441|Rhodospirillales	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HFD1_k127_1823014_4	234267.Acid_1239	5.989e-84	294.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HAMP,Response_reg,SpoIIE
HFD1_k127_1823014_0	234267.Acid_4267	1.082e-271	859.0	COG0577@1|root,COG0577@2|Bacteria,3Y3U3@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1823014_5	234267.Acid_2380	5.743e-60	214.0	COG2133@1|root,COG3292@1|root,COG2133@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,CHB_HEX_C_1,DUF1906,Glyco_hydro_18,Malectin,PA14,SLH,VCBS
HFD1_k127_1823749_8	1267534.KB906756_gene237	1.219e-45	168.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria,2JIMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HFD1_k127_1823749_0	234267.Acid_1747	1.073e-197	625.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
HFD1_k127_1823749_11	673860.AciM339_0955	9.92e-09	68.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,3F2NI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HFD1_k127_1823749_1	234267.Acid_2871	3.417e-177	566.0	COG3119@1|root,COG3119@2|Bacteria,3Y679@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HFD1_k127_1823749_6	1340493.JNIF01000004_gene1024	1.592e-67	252.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HFD1_k127_1823749_3	234267.Acid_2872	3.517e-136	454.0	COG1520@1|root,COG1520@2|Bacteria,3Y3UP@57723|Acidobacteria	57723|Acidobacteria	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
HFD1_k127_1823749_4	234267.Acid_6207	1.035e-102	340.0	COG1191@1|root,COG1191@2|Bacteria,3Y6IE@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HFD1_k127_1823749_7	234267.Acid_1337	1.936e-65	232.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase
HFD1_k127_1823749_5	234267.Acid_6206	3.067e-90	309.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria	57723|Acidobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
HFD1_k127_1823749_2	234267.Acid_6205	9.806e-138	445.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_1823749_10	234267.Acid_6204	9.536e-11	62.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HFD1_k127_1827928_2	398512.JQKC01000034_gene4930	2.36e-07	52.0	COG1961@1|root,COG1961@2|Bacteria,1UZT3@1239|Firmicutes,25BHM@186801|Clostridia,3WS5N@541000|Ruminococcaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HFD1_k127_1827928_0	1079460.ATTQ01000029_gene4706	1.806e-202	638.0	COG0784@1|root,COG3920@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,HWE_HK,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
HFD1_k127_1827928_1	366602.Caul_0471	1.486e-128	422.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U4H4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_9
HFD1_k127_18321_1	1247726.MIM_c12250	9.617e-146	469.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2VK61@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD1_k127_18321_0	234267.Acid_2874	4.595e-147	474.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
HFD1_k127_18321_8	234267.Acid_2407	5.068e-31	126.0	COG3744@1|root,COG3744@2|Bacteria,3Y8E1@57723|Acidobacteria	57723|Acidobacteria	S	PFAM PilT protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_18321_9	234267.Acid_2406	1.051e-21	96.0	COG4118@1|root,COG4118@2|Bacteria,3Y5YY@57723|Acidobacteria	57723|Acidobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD1_k127_18321_5	234267.Acid_1252	4.332e-89	300.0	COG1360@1|root,COG1360@2|Bacteria,3Y47G@57723|Acidobacteria	57723|Acidobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HFD1_k127_18321_6	204669.Acid345_3481	2.017e-79	275.0	COG1291@1|root,COG1291@2|Bacteria,3Y3Y8@57723|Acidobacteria,2JI9S@204432|Acidobacteriia	204432|Acidobacteriia	N	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HFD1_k127_18321_4	234267.Acid_5774	8.802e-92	304.0	COG3861@1|root,COG3861@2|Bacteria,3Y5WZ@57723|Acidobacteria	57723|Acidobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD1_k127_18321_7	234267.Acid_5775	4.95e-31	126.0	COG2823@1|root,COG2823@2|Bacteria,3Y8FT@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD1_k127_18321_2	234267.Acid_3862	1.875e-133	435.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_18321_3	234267.Acid_1228	2.188e-92	316.0	COG3595@1|root,COG3595@2|Bacteria,3Y5MS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD1_k127_18321_11	1227499.C493_12958	0.0004353	44.0	COG0642@1|root,arCOG02352@1|root,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,2Y7KE@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_4
HFD1_k127_18321_10	1385515.N791_06505	1.984e-11	66.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1X3PD@135614|Xanthomonadales	135614|Xanthomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD1_k127_1834_0	338969.Rfer_4079	7.469e-185	594.0	COG3303@1|root,COG3303@2|Bacteria,1NT38@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1849933_4	1123261.AXDW01000001_gene1023	2.446e-34	148.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,1SABC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HFD1_k127_1849933_3	1267535.KB906767_gene2789	2.494e-44	172.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1849933_1	234267.Acid_0288	2.251e-49	186.0	COG0394@1|root,COG0394@2|Bacteria,3Y8RC@57723|Acidobacteria	57723|Acidobacteria	T	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
HFD1_k127_1849933_0	234267.Acid_0289	8.668e-81	277.0	COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HFD1_k127_1849933_2	234267.Acid_0290	5.155e-46	166.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the PdxS SNZ family	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD1_k127_1889954_4	1122605.KB893648_gene3690	2.808e-11	64.0	28J61@1|root,2Z91S@2|Bacteria,4NKJU@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_129
HFD1_k127_1889954_2	1122605.KB893648_gene3690	7.294e-190	612.0	28J61@1|root,2Z91S@2|Bacteria,4NKJU@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_129
HFD1_k127_1889954_0	1340493.JNIF01000004_gene235	3.69e-266	860.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_1889954_3	1267535.KB906767_gene320	1.345e-136	445.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,Big_2,CBM_X2,CHB_HEX_C_1,F5_F8_type_C,FIVAR,Glyco_hyd_65N_2,Melibiase_2
HFD1_k127_1889954_1	234267.Acid_0535	1.801e-223	719.0	COG1554@1|root,COG1554@2|Bacteria,3Y5FD@57723|Acidobacteria	57723|Acidobacteria	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1901967_1	234267.Acid_3563	5.188e-128	411.0	COG1793@1|root,COG1793@2|Bacteria,3Y3AP@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD1_k127_1901967_2	1267535.KB906767_gene4999	1.257e-103	346.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Calx-beta,CarboxypepD_reg,DUF1080,F5_F8_type_C,G5,G8,Glyco_hyd_101C,Glyco_hydro_101,Trypsin_2,YSIRK_signal,fn3
HFD1_k127_1901967_0	234267.Acid_3564	3.893e-220	687.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_1905487_4	1429916.X566_21020	1.37e-54	202.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD1_k127_1905487_3	234267.Acid_3660	6.985e-61	215.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD1_k127_1905487_2	234267.Acid_1657	2.133e-114	378.0	COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_1905487_0	234267.Acid_1656	1.534e-199	630.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_1905487_1	234267.Acid_1655	3.462e-117	381.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1907548_2	234267.Acid_4616	5.1e-81	278.0	COG2199@1|root,COG3706@2|Bacteria,3Y4ZC@57723|Acidobacteria	57723|Acidobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HFD1_k127_1907548_0	234267.Acid_2813	1.158e-301	956.0	COG0577@1|root,COG0577@2|Bacteria,3Y6QF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_1907548_3	234267.Acid_6487	1.951e-80	284.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD1_k127_1907548_1	234267.Acid_4994	1.66e-123	407.0	COG0101@1|root,COG0101@2|Bacteria,3Y2MS@57723|Acidobacteria	57723|Acidobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD1_k127_1907548_4	234267.Acid_4993	4.955e-71	243.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD1_k127_1910725_4	1192034.CAP_0299	1.2e-34	136.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,4300W@68525|delta/epsilon subdivisions,2X35W@28221|Deltaproteobacteria,2YUEH@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_1910725_0	234267.Acid_2690	9.823e-109	363.0	COG3391@1|root,COG3391@2|Bacteria,3Y7IA@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1910725_2	234267.Acid_3522	3.867e-55	203.0	2DKN8@1|root,32UFB@2|Bacteria,3Y55I@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4252
HFD1_k127_1910725_5	1267535.KB906767_gene3331	2.558e-06	56.0	2ERSC@1|root,33JBJ@2|Bacteria,3Y5XV@57723|Acidobacteria,2JK5S@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1910725_1	234267.Acid_3520	1.386e-64	233.0	COG1595@1|root,COG1595@2|Bacteria,3Y5BF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_1915804_5	756272.Plabr_2698	2.664e-53	205.0	COG2960@1|root,COG2960@2|Bacteria,2IX87@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD1_k127_1915804_1	1192034.CAP_9004	2.148e-88	315.0	COG5297@1|root,COG5297@2|Bacteria,1PG5N@1224|Proteobacteria,439EZ@68525|delta/epsilon subdivisions,2X4Q8@28221|Deltaproteobacteria,2YZDX@29|Myxococcales	28221|Deltaproteobacteria	G	CBD_II	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD1_k127_1915804_0	1123508.JH636446_gene6244	4.347e-174	562.0	COG3653@1|root,COG3653@2|Bacteria,2IXWQ@203682|Planctomycetes	203682|Planctomycetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HFD1_k127_1915804_6	1267535.KB906767_gene1940	1.57e-26	111.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	VY92_08690	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HFD1_k127_1915804_4	234267.Acid_2201	4.521e-57	204.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Big_3_2,DUF4157,DUF922,OmpA,PA14
HFD1_k127_1915804_2	861299.J421_1196	3.816e-88	310.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	exuT	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_1915804_3	1267535.KB906767_gene1481	1.812e-87	295.0	COG1028@1|root,COG1028@2|Bacteria	1267535.KB906767_gene1481|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1915804_7	1340493.JNIF01000003_gene1740	2.882e-19	89.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_1920982_10	1343739.PAP_01505	9.253e-11	65.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota,242VZ@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
HFD1_k127_1920982_1	234267.Acid_1653	6.645e-205	647.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD1_k127_1920982_9	760192.Halhy_3568	5.361e-17	92.0	COG1082@1|root,COG1082@2|Bacteria,4PJ9G@976|Bacteroidetes,1IZP5@117747|Sphingobacteriia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_1920982_11	180281.CPCC7001_1564	1.069e-05	55.0	COG3439@1|root,COG3439@2|Bacteria,1GMBF@1117|Cyanobacteria,22T0T@167375|Cyanobium	1117|Cyanobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HFD1_k127_1920982_4	1121920.AUAU01000004_gene859	1.497e-133	447.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria	57723|Acidobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD1_k127_1920982_8	186497.PF0939	3.257e-45	169.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,243TQ@183968|Thermococci	183968|Thermococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD1	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD1_k127_1920982_5	580340.Tlie_1564	3.93e-131	431.0	COG0065@1|root,COG0065@2|Bacteria,3TA6N@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD1_k127_1920982_6	891968.Anamo_1299	9.878e-80	278.0	COG2513@1|root,COG2513@2|Bacteria,3TAPQ@508458|Synergistetes	508458|Synergistetes	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD1_k127_1920982_3	234267.Acid_5354	2.901e-169	539.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria	57723|Acidobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
HFD1_k127_1920982_7	234267.Acid_1111	1.319e-75	255.0	COG0735@1|root,COG0735@2|Bacteria,3Y7UH@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD1_k127_1920982_0	522306.CAP2UW1_2411	0.0	1250.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1KQDT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HFD1_k127_1920982_2	234267.Acid_5353	3.432e-195	627.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria	57723|Acidobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD1_k127_1926793_1	234267.Acid_1438	1.455e-106	356.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_1926793_2	234267.Acid_1437	1.112e-80	282.0	COG4975@1|root,COG4975@2|Bacteria,3Y6YG@57723|Acidobacteria	57723|Acidobacteria	G	Ureide permease	-	-	-	ko:K05340	-	-	-	-	ko00000,ko02000	2.A.7.5	-	-	Ureide_permease
HFD1_k127_1926793_0	234267.Acid_1436	7.375e-123	397.0	COG3684@1|root,COG3981@1|root,COG3684@2|Bacteria,COG3981@2|Bacteria,3Y33H@57723|Acidobacteria	57723|Acidobacteria	G	deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD1_k127_1933078_0	234267.Acid_5553	6.343e-122	402.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_1933078_1	234267.Acid_2132	5.657e-102	345.0	COG1028@1|root,COG1028@2|Bacteria,3Y7BE@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_1933078_3	234267.Acid_2133	1.759e-36	144.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	puhB	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
HFD1_k127_1933078_2	234267.Acid_2134	3.77e-98	329.0	2AC2T@1|root,311KW@2|Bacteria,3Y4QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_195077_5	936455.KI421499_gene6278	3.844e-38	159.0	COG0402@1|root,COG0402@2|Bacteria,1R9S5@1224|Proteobacteria,2U10N@28211|Alphaproteobacteria,3JU9Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_195077_1	234267.Acid_1271	7.534e-215	680.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_195077_4	1267535.KB906767_gene4431	1.83e-86	297.0	COG0628@1|root,COG0628@2|Bacteria,3Y40R@57723|Acidobacteria,2JIX8@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_195077_2	234267.Acid_7163	2.165e-175	559.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase
HFD1_k127_195077_7	1288826.MSNKSG1_00943	1.677e-09	68.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,466CN@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HFD1_k127_195077_3	1335760.ASTG01000011_gene416	1.134e-119	406.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2TV6G@28211|Alphaproteobacteria,2K8KF@204457|Sphingomonadales	204457|Sphingomonadales	O	Carbamoyltransferase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD1_k127_195077_6	269797.Mbar_A0185	1.522e-34	146.0	COG0037@1|root,arCOG15275@2157|Archaea,2Y0EE@28890|Euryarchaeota,2NB74@224756|Methanomicrobia	224756|Methanomicrobia	D	TIGRFAM N-acetyl sugar amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	QueC
HFD1_k127_195077_0	234267.Acid_5051	1.144e-226	735.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_1962740_9	234267.Acid_4945	1.368e-61	218.0	2B33H@1|root,31VR5@2|Bacteria,3Y819@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1962740_2	234267.Acid_4944	3.806e-246	766.0	COG0531@1|root,COG0531@2|Bacteria,3Y3SZ@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_1962740_3	234267.Acid_4943	1.008e-229	726.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_1962740_11	682795.AciX8_1564	6.695e-42	161.0	COG0352@1|root,COG0352@2|Bacteria,3Y4Y5@57723|Acidobacteria,2JJM3@204432|Acidobacteriia	204432|Acidobacteriia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD1_k127_1962740_13	234267.Acid_4941	7.394e-36	138.0	COG1225@1|root,COG1225@2|Bacteria,3Y7Y4@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_1962740_15	234267.Acid_4941	5.353e-17	90.0	COG1225@1|root,COG1225@2|Bacteria,3Y7Y4@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_1962740_1	234267.Acid_4940	1.917e-284	901.0	COG1409@1|root,COG1657@1|root,COG4412@1|root,COG1409@2|Bacteria,COG1657@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K14647,ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko03110	1.B.40.2	-	-	CARDB,Peptidase_M30
HFD1_k127_1962740_0	234267.Acid_4936	0.0	1012.0	COG2366@1|root,COG2366@2|Bacteria,3Y2PX@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD1_k127_1962740_4	234267.Acid_4935	1.004e-186	593.0	COG1253@1|root,COG1253@2|Bacteria,3Y2KE@57723|Acidobacteria	57723|Acidobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HFD1_k127_1962740_5	234267.Acid_4934	9.038e-115	379.0	COG0628@1|root,COG0628@2|Bacteria,3Y4YN@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_1962740_6	234267.Acid_4933	8.766e-110	374.0	COG2370@1|root,COG2370@2|Bacteria	2|Bacteria	O	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ,NicO
HFD1_k127_1962740_14	1267534.KB906754_gene3222	1.698e-26	126.0	2F1DC@1|root,33UE4@2|Bacteria,3Y7M2@57723|Acidobacteria,2JMR0@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1962740_7	1267534.KB906754_gene3223	8.62e-93	317.0	COG1131@1|root,COG1131@2|Bacteria,3Y6H3@57723|Acidobacteria,2JM7H@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD1_k127_1962740_12	1267534.KB906754_gene3224	1.3e-36	142.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD1_k127_1962740_8	234267.Acid_6222	1.594e-69	238.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria	57723|Acidobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD1_k127_1962740_10	234267.Acid_6223	3.22e-47	170.0	COG0054@1|root,COG0054@2|Bacteria,3Y3RR@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD1_k127_1964332_0	234267.Acid_5945	2.982e-272	844.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HFD1_k127_1964332_1	204669.Acid345_1410	7.923e-176	567.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD1_k127_1964332_2	234267.Acid_0673	7.856e-116	398.0	COG2271@1|root,COG2271@2|Bacteria,3Y3W5@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_1964332_4	1340493.JNIF01000004_gene910	4.705e-50	203.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD1_k127_1964332_3	234267.Acid_7543	2.924e-115	383.0	COG0823@1|root,COG0823@2|Bacteria,3Y6DB@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_1964332_5	234267.Acid_4295	1.943e-19	91.0	COG2208@1|root,COG4753@1|root,COG2208@2|Bacteria,COG4753@2|Bacteria,3Y6AE@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
HFD1_k127_2013529_4	234267.Acid_6719	2.096e-143	462.0	COG1228@1|root,COG1228@2|Bacteria,3Y6WV@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_2013529_2	221288.JH992901_gene4734	8.53e-156	505.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_2013529_0	234267.Acid_1924	1.218e-296	915.0	COG0488@1|root,COG0488@2|Bacteria,3Y3IA@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD1_k127_2013529_1	234267.Acid_5247	1.627e-157	505.0	COG2382@1|root,COG2382@2|Bacteria,3Y98J@57723|Acidobacteria	57723|Acidobacteria	P	glycoside hydrolase, family 13 domain protein	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_2013529_6	575540.Isop_0300	3.993e-106	358.0	COG2382@1|root,COG2382@2|Bacteria,2IYMZ@203682|Planctomycetes	203682|Planctomycetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
HFD1_k127_2013529_7	323261.Noc_1108	7.58e-20	90.0	COG1598@1|root,COG1598@2|Bacteria,1NPTZ@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2013529_8	41431.PCC8801_0852	7.005e-07	54.0	COG1724@1|root,COG1724@2|Bacteria,1GAH0@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_2013529_3	1340493.JNIF01000004_gene823	4.004e-152	485.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HFD1_k127_2013529_5	234267.Acid_0784	1.864e-107	355.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_2025452_0	234267.Acid_7357	1.326e-145	468.0	COG0318@1|root,COG0318@2|Bacteria,3Y68M@57723|Acidobacteria	57723|Acidobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD1_k127_2025452_2	234267.Acid_7355	2.69e-62	216.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_2025452_1	234267.Acid_7354	5.109e-144	475.0	COG0729@1|root,COG0729@2|Bacteria	2|Bacteria	M	surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag
HFD1_k127_2036878_20	652103.Rpdx1_4700	4.702e-19	90.0	COG1724@1|root,COG1724@2|Bacteria,1N7S3@1224|Proteobacteria,2UGAG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_2036878_18	497965.Cyan7822_5146	3.536e-23	100.0	COG1598@1|root,COG1598@2|Bacteria,1G985@1117|Cyanobacteria,3KJ0G@43988|Cyanothece	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD1_k127_2036878_7	234267.Acid_5850	2.114e-157	503.0	COG1975@1|root,COG1975@2|Bacteria,3Y54Y@57723|Acidobacteria	57723|Acidobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD1_k127_2036878_15	234267.Acid_5849	1.726e-54	199.0	COG2068@1|root,COG2068@2|Bacteria	2|Bacteria	NU	MobA-Related Protein	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD1_k127_2036878_0	234267.Acid_5848	2.645e-306	967.0	COG2982@1|root,COG2982@2|Bacteria,3Y3Z4@57723|Acidobacteria	57723|Acidobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HFD1_k127_2036878_12	234267.Acid_5845	3.98e-83	284.0	28JIP@1|root,2Z82C@2|Bacteria,3Y82Y@57723|Acidobacteria	57723|Acidobacteria	S	PFAM S1 P1 nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HFD1_k127_2036878_14	234267.Acid_2743	1.415e-55	196.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	234267.Acid_2743|-	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2036878_17	234267.Acid_2744	1.204e-25	106.0	2EK70@1|root,33DXD@2|Bacteria,3Y5QD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2036878_3	234267.Acid_2745	1.254e-221	690.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD1_k127_2036878_11	234267.Acid_2746	6.002e-86	302.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria	57723|Acidobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD1_k127_2036878_9	234267.Acid_2747	5.127e-143	467.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria	57723|Acidobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD1_k127_2036878_5	234267.Acid_2748	2.666e-193	608.0	COG1364@1|root,COG1364@2|Bacteria,3Y2PH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD1_k127_2036878_6	234267.Acid_1399	1.885e-176	560.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HFD1_k127_2036878_8	234267.Acid_2636	7.093e-154	495.0	COG0845@1|root,COG0845@2|Bacteria,3Y43D@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD1_k127_2036878_1	234267.Acid_2635	6.725e-240	746.0	COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria	2|Bacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD1_k127_2036878_4	234267.Acid_2474	1.942e-198	625.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD1_k127_2036878_10	234267.Acid_2475	1.057e-104	357.0	COG0697@1|root,COG0697@2|Bacteria,3Y3CN@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_2036878_2	234267.Acid_2476	3.418e-231	726.0	COG0265@1|root,COG0265@2|Bacteria,3Y2SD@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_2036878_13	234267.Acid_1005	4.378e-67	234.0	COG1073@1|root,COG1073@2|Bacteria,3Y5MV@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family (UPF0227)	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	UPF0227
HFD1_k127_2036917_3	1123393.KB891327_gene473	1.147e-09	59.0	COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HFD1_k127_2036917_1	1123393.KB891316_gene1541	4.607e-94	313.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria	28216|Betaproteobacteria	L	glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HFD1_k127_2036917_0	1249627.D779_1712	1.867e-168	535.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria,1WW4V@135613|Chromatiales	135613|Chromatiales	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
HFD1_k127_2036917_2	580332.Slit_0882	2.016e-81	273.0	COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2VHMG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrogenase molybdenum-iron protein alpha chain	nifD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
HFD1_k127_20596_0	234267.Acid_2928	0.0	1308.0	COG0243@1|root,COG0243@2|Bacteria,3Y2HB@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD1_k127_20596_2	1254432.SCE1572_23370	1.033e-105	370.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_20596_3	525904.Tter_2535	2.962e-100	354.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	narK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02575,ko:K10850	ko00910,ko02020,map00910,map02020	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iYO844.BSU37320	MFS_1,PAS_9
HFD1_k127_20596_5	234267.Acid_2934	1.21e-57	206.0	COG3945@1|root,COG3945@2|Bacteria,3Y5T8@57723|Acidobacteria	57723|Acidobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD1_k127_20596_1	1267534.KB906760_gene1427	8.41e-135	445.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD1_k127_20596_6	234267.Acid_5937	1.757e-55	211.0	COG3193@1|root,COG3193@2|Bacteria,3Y7TK@57723|Acidobacteria	57723|Acidobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD1_k127_20596_4	234267.Acid_7292	1.535e-97	327.0	COG1233@1|root,COG1233@2|Bacteria,3Y9B4@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD1_k127_206281_1	1408473.JHXO01000008_gene2837	3.967e-53	195.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
HFD1_k127_206281_0	1408473.JHXO01000008_gene2836	9.083e-158	511.0	COG4403@1|root,COG4403@2|Bacteria,4PMC1@976|Bacteroidetes	976|Bacteroidetes	V	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_206281_2	1280944.HY17_10090	6.004e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,43WYB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_2,TPR_8
HFD1_k127_2064014_2	234267.Acid_1186	1.545e-129	418.0	COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HFD1_k127_2064014_3	234267.Acid_0870	2.719e-61	229.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_2064014_1	234267.Acid_0871	1.112e-310	983.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_0871|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_2064014_0	234267.Acid_0872	0.0	1686.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_2088451_18	1532557.JL37_08115	2.866e-29	127.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,3T4CS@506|Alcaligenaceae	28216|Betaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	DUF1932,NAD_binding_2
HFD1_k127_2088451_19	234267.Acid_0092	1.432e-26	115.0	COG2272@1|root,COG2272@2|Bacteria,3Y2GS@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_2088451_6	1382306.JNIM01000001_gene2722	2.802e-137	456.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_2088451_5	234267.Acid_6772	8.59e-142	468.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_2088451_0	1340493.JNIF01000003_gene3160	0.0	1172.0	COG1984@1|root,COG1984@2|Bacteria	2|Bacteria	E	allophanate hydrolase subunit 2	kipA	-	6.3.4.6	ko:K01941,ko:K06350	ko00220,ko00791,ko01100,map00220,map00791,map01100	-	R00774	RC00378	ko00000,ko00001,ko01000	-	-	-	CT_A_B,CT_C_D,SLH
HFD1_k127_2088451_8	1281779.H009_06112	3.676e-118	393.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,2VE1T@28211|Alphaproteobacteria,4BJ43@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_2088451_15	264198.Reut_B5774	4.499e-59	214.0	COG0684@1|root,COG0684@2|Bacteria,1QSHP@1224|Proteobacteria,2VJV8@28216|Betaproteobacteria,1K0T1@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD1_k127_2088451_4	859657.RPSI07_mp0008	3.744e-174	556.0	COG0477@1|root,COG0477@2|Bacteria,1MVZG@1224|Proteobacteria,2VHUI@28216|Betaproteobacteria,1K37X@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K03761	-	-	-	-	ko00000,ko02000	2.A.1.6.2	-	-	Sugar_tr
HFD1_k127_2088451_10	1120971.AUCA01000071_gene1262	4.38e-104	346.0	COG1099@1|root,COG1099@2|Bacteria,1V5KM@1239|Firmicutes,4HTD0@91061|Bacilli	91061|Bacilli	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2088451_12	234267.Acid_4419	2.141e-95	328.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2088451_14	1380394.JADL01000001_gene2971	2.742e-69	259.0	COG1028@1|root,COG1028@2|Bacteria,1R7JW@1224|Proteobacteria,2U3FH@28211|Alphaproteobacteria,2JWFW@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_2088451_7	864051.BurJ1DRAFT_2775	1.295e-134	458.0	COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2WEME@28216|Betaproteobacteria,1KN2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_2088451_17	497964.CfE428DRAFT_1821	3.87e-53	213.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_2088451_2	266264.Rmet_3709	2.314e-202	639.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,1K5KG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HFD1_k127_2088451_20	663610.JQKO01000003_gene1473	2.344e-26	115.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2UBP8@28211|Alphaproteobacteria,3NBJ7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HFD1_k127_2088451_1	1297865.APJD01000003_gene6495	6.228e-206	659.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,3JX83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_2088451_21	392499.Swit_1527	7.49e-16	84.0	COG2010@1|root,COG2010@2|Bacteria,1NK3D@1224|Proteobacteria,2UN55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_2088451_22	1267533.KB906739_gene2470	2.726e-09	63.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	exaA	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD1_k127_2088451_9	1267535.KB906767_gene4986	8.506e-110	369.0	COG2382@1|root,COG2382@2|Bacteria,3Y98J@57723|Acidobacteria,2JP52@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_2088451_13	1230476.C207_05701	1.2e-85	291.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2U1JI@28211|Alphaproteobacteria,3JUZJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD1_k127_2088451_3	264198.Reut_A1366	8.198e-188	596.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHD2@28216|Betaproteobacteria,1K0HV@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	TIGRFAM metabolite H symporter, major facilitator superfamily (MFS)	citA	-	-	ko:K03288	-	-	-	-	ko00000,ko02000	2.A.1.6.1,2.A.1.6.7	-	-	MFS_1,Sugar_tr
HFD1_k127_2088451_11	1382359.JIAL01000001_gene998	9.328e-101	336.0	COG1402@1|root,COG1402@2|Bacteria,3Y3IW@57723|Acidobacteria,2JHT5@204432|Acidobacteriia	204432|Acidobacteriia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HFD1_k127_2088451_23	627192.SLG_35080	0.0002154	52.0	COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,2K8E7@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_2088451_16	935840.JAEQ01000023_gene4306	2.613e-57	203.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U7NJ@28211|Alphaproteobacteria,43R40@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_2175645_3	234267.Acid_0394	4.144e-207	658.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_2175645_6	234267.Acid_0393	2e-53	212.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HFD1_k127_2175645_1	234267.Acid_0392	8.055e-237	741.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_2175645_8	1163617.SCD_n02865	4.637e-19	102.0	COG4627@1|root,COG4627@2|Bacteria,1RKW8@1224|Proteobacteria	1224|Proteobacteria	S	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_2175645_9	1346330.M472_13380	2.148e-18	100.0	COG3622@1|root,COG3622@2|Bacteria,4PM6P@976|Bacteroidetes	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_2175645_2	1267535.KB906767_gene5450	5.652e-215	678.0	COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_2175645_7	234267.Acid_1782	9.616e-41	158.0	2CDPE@1|root,33992@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2809)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2809
HFD1_k127_2175645_5	234267.Acid_2707	3.844e-141	457.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HFD1_k127_2175645_0	234267.Acid_0349	0.0	1358.0	COG0438@1|root,COG1232@1|root,COG0438@2|Bacteria,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	tuaH	-	5.4.99.9	ko:K01854,ko:K07011	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,GLF,Glyco_trans_1_4,NAD_binding_8
HFD1_k127_2175645_4	234267.Acid_6729	3.727e-202	632.0	COG1012@1|root,COG1012@2|Bacteria,3Y384@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_2194993_12	234267.Acid_1032	1.389e-50	186.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
HFD1_k127_2194993_11	234267.Acid_4324	1.378e-51	188.0	COG3682@1|root,COG3682@2|Bacteria,3Y573@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_2194993_9	234267.Acid_4323	3.226e-58	230.0	COG4219@1|root,COG4219@2|Bacteria,3Y5JT@57723|Acidobacteria	57723|Acidobacteria	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
HFD1_k127_2194993_13	234267.Acid_1280	6.329e-24	119.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_2194993_1	234267.Acid_0993	1.084e-291	906.0	COG1132@1|root,COG1132@2|Bacteria,3Y2XY@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD1_k127_2194993_14	1219049.SP5_074_00200	8.504e-19	98.0	COG4403@1|root,COG4403@2|Bacteria,1NCPK@1224|Proteobacteria,2UJSZ@28211|Alphaproteobacteria,2K4BX@204457|Sphingomonadales	204457|Sphingomonadales	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2194993_5	234267.Acid_3345	1.029e-105	347.0	COG0684@1|root,COG0684@2|Bacteria,3Y3TT@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD1_k127_2194993_2	234267.Acid_3524	1.808e-205	649.0	COG4948@1|root,COG4948@2|Bacteria,3Y403@57723|Acidobacteria	57723|Acidobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_2194993_6	522306.CAP2UW1_2764	8.624e-104	346.0	COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria	1224|Proteobacteria	O	cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
HFD1_k127_2194993_0	1340493.JNIF01000003_gene2166	0.0	1115.0	COG1629@1|root,COG4771@2|Bacteria,3Y36T@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_2194993_10	234267.Acid_5527	3.412e-58	205.0	COG2967@1|root,COG2967@2|Bacteria	2|Bacteria	P	mitochondrion morphogenesis	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HFD1_k127_2194993_8	234267.Acid_6615	1.345e-79	275.0	28KX8@1|root,2ZAD8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2194993_7	1121472.AQWN01000011_gene1204	1.926e-97	348.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,2624Y@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD1_k127_2194993_3	926550.CLDAP_27320	5.099e-129	443.0	COG1129@1|root,COG1129@2|Bacteria,2G649@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441,ko:K10545,ko:K10548	ko02010,map02010	M00212,M00215,M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
HFD1_k127_2194993_4	234267.Acid_1479	4.1e-114	381.0	COG1609@1|root,COG1609@2|Bacteria,3Y6K5@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD1_k127_219703_0	234267.Acid_4427	0.0	1692.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria	57723|Acidobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD1_k127_219703_1	234267.Acid_4428	1.444e-94	316.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD1_k127_219703_3	234267.Acid_3872	1.911e-51	183.0	2CIU6@1|root,32S8H@2|Bacteria,3Y8IT@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_219703_2	234267.Acid_5517	9.412e-54	194.0	COG0657@1|root,COG0657@2|Bacteria,3Y44Z@57723|Acidobacteria	57723|Acidobacteria	I	Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_219703_4	1267535.KB906767_gene5149	2.594e-16	81.0	COG1652@1|root,COG1652@2|Bacteria,3Y84E@57723|Acidobacteria	57723|Acidobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD1_k127_220977_2	215803.DB30_2329	4.037e-06	52.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1NR2V@1224|Proteobacteria,42YIK@68525|delta/epsilon subdivisions,2WUNG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MV	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_220977_1	1128421.JAGA01000001_gene2241	1.046e-67	237.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_220977_0	1183438.GKIL_4354	7.453e-140	480.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2210017_21	234267.Acid_2365	1.418e-13	72.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD1_k127_2210017_4	1267535.KB906767_gene798	2.838e-203	644.0	COG3669@1|root,COG3669@2|Bacteria,3Y36K@57723|Acidobacteria,2JIX7@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-fucosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,Fucosidase_C
HFD1_k127_2210017_17	234267.Acid_3083	6.135e-36	147.0	COG3595@1|root,COG3595@2|Bacteria,3Y5AF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2210017_14	521011.Mpal_2461	2.802e-50	205.0	COG0642@1|root,arCOG02358@2157|Archaea,2Y7KE@28890|Euryarchaeota,2NA6H@224756|Methanomicrobia	28890|Euryarchaeota	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,HisKA_4TM,PAS_3,PAS_4,PAS_9
HFD1_k127_2210017_10	596152.DesU5LDRAFT_1358	1.72e-77	292.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X7X2@28221|Deltaproteobacteria,2MHFY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg,dCache_1
HFD1_k127_2210017_18	1267535.KB906767_gene2892	8.476e-24	105.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD1_k127_2210017_7	1267535.KB906767_gene2893	3.503e-136	448.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_2210017_19	748247.AZKH_1668	2.034e-21	108.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria,2KWRM@206389|Rhodocyclales	206389|Rhodocyclales	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_2210017_20	1340493.JNIF01000004_gene140	1.209e-14	81.0	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269,YflT
HFD1_k127_2210017_3	234267.Acid_4914	1.501e-210	662.0	COG0531@1|root,COG0531@2|Bacteria,3Y3Z8@57723|Acidobacteria	2|Bacteria	E	amino acid	frlA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039	-	ko:K03294,ko:K19540	-	-	-	-	ko00000,ko02000	2.A.3.2,2.A.3.8.17	-	iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365	AA_permease_2
HFD1_k127_2210017_11	234267.Acid_7139	4.525e-73	262.0	COG4449@1|root,COG4449@2|Bacteria,3Y84G@57723|Acidobacteria	57723|Acidobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HFD1_k127_2210017_6	234267.Acid_7137	4.952e-139	451.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD1_k127_2210017_5	234267.Acid_7136	9.987e-196	617.0	COG0743@1|root,COG0743@2|Bacteria,3Y30J@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD1_k127_2210017_2	234267.Acid_7135	6.037e-214	671.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria	57723|Acidobacteria	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HFD1_k127_2210017_1	234267.Acid_7134	7.69e-232	750.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
HFD1_k127_2210017_15	234267.Acid_7130	2.826e-41	157.0	2FHRB@1|root,349IU@2|Bacteria,3Y8GP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2210017_13	234267.Acid_7129	8.08e-58	205.0	COG0662@1|root,COG0662@2|Bacteria,3Y5D0@57723|Acidobacteria	57723|Acidobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2210017_16	234267.Acid_7128	1.442e-38	147.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	57723|Acidobacteria	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2210017_12	234267.Acid_2014	7.628e-60	220.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD1_k127_2210017_8	234267.Acid_7127	2.436e-125	404.0	COG1691@1|root,COG1691@2|Bacteria,3Y3BX@57723|Acidobacteria	57723|Acidobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD1_k127_2210017_0	234267.Acid_7846	0.0	1018.0	COG0365@1|root,COG0365@2|Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD1_k127_2210017_22	1382359.JIAL01000001_gene2659	7.1e-13	80.0	COG2706@1|root,COG2706@2|Bacteria,3Y76Q@57723|Acidobacteria,2JMA2@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_2219799_0	278963.ATWD01000001_gene1304	0.0	1149.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_2219799_4	234267.Acid_2574	9.913e-69	235.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD,Ribosomal_S30AE,zf-trcl
HFD1_k127_2219799_1	234267.Acid_2573	1.108e-260	807.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HFD1_k127_2219799_5	234267.Acid_2572	5.56e-38	143.0	COG0228@1|root,COG0228@2|Bacteria,3Y56G@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD1_k127_2219799_6	234267.Acid_2571	2.531e-36	138.0	COG1837@1|root,COG1837@2|Bacteria,3Y5N5@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HFD1_k127_2219799_3	234267.Acid_2570	6.632e-73	250.0	COG0806@1|root,COG0806@2|Bacteria	2|Bacteria	J	ribosome binding	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HFD1_k127_2219799_2	234267.Acid_2569	2.848e-125	413.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD1_k127_2222999_0	234267.Acid_4167	9.051e-48	171.0	COG3185@1|root,COG3185@2|Bacteria,3Y2ST@57723|Acidobacteria	57723|Acidobacteria	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HFD1_k127_2222999_1	1267535.KB906767_gene4935	2.475e-46	179.0	COG0179@1|root,COG0179@2|Bacteria,3Y4BX@57723|Acidobacteria,2JJD1@204432|Acidobacteriia	204432|Acidobacteriia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	ko:K18336	ko00051,ko01120,map00051,map01120	-	R10691	RC00326,RC03236	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HFD1_k127_2222999_2	234267.Acid_4047	8.188e-26	107.0	COG1643@1|root,COG1643@2|Bacteria,3Y38N@57723|Acidobacteria	57723|Acidobacteria	L	ATP-dependent helicase HrpB	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HFD1_k127_2226996_4	234267.Acid_3856	8.148e-12	64.0	COG0040@1|root,COG0040@2|Bacteria,3Y31Q@57723|Acidobacteria	57723|Acidobacteria	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HFD1_k127_2226996_0	234267.Acid_3855	8.171e-199	627.0	COG0141@1|root,COG0141@2|Bacteria,3Y2N7@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HFD1_k127_2226996_1	234267.Acid_3854	2.365e-180	582.0	COG0079@1|root,COG0079@2|Bacteria,3Y3M6@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_2226996_3	234267.Acid_3853	7.271e-95	329.0	COG0546@1|root,COG0546@2|Bacteria,3Y7JG@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K11777	-	-	-	-	ko00000	-	-	-	HAD_2
HFD1_k127_2226996_2	234267.Acid_3852	1.406e-111	364.0	COG0131@1|root,COG0131@2|Bacteria,3Y3DU@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HFD1_k127_2226996_5	1340493.JNIF01000003_gene1904	0.0002934	48.0	COG0118@1|root,COG0118@2|Bacteria,3Y5DZ@57723|Acidobacteria	57723|Acidobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD1_k127_2230911_2	1250006.JHZZ01000001_gene617	5.162e-11	76.0	COG2911@1|root,COG3266@1|root,COG3291@1|root,COG2911@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,4PMB4@976|Bacteroidetes,1IJQ6@117743|Flavobacteriia,3VWVT@52959|Polaribacter	976|Bacteroidetes	S	Domain of unknown function (DUF5011)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,FG-GAP_2
HFD1_k127_2230911_0	1123508.JH636439_gene1021	5.642e-25	122.0	COG0726@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG4625@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	quiC	-	3.2.1.156,3.2.1.65,3.4.24.40,4.2.1.118	ko:K01212,ko:K01406,ko:K09483,ko:K15531	ko00400,ko00500,ko01110,ko01130,ko01503,map00400,map00500,map01110,map01130,map01503	-	R01627,R05624,R11311	RC00568,RC03278	ko00000,ko00001,ko01000,ko01002	-	GH32,GH8	-	Beta_helix,Calx-beta,NosD
HFD1_k127_2230911_1	1484460.JSWG01000015_gene1033	1.075e-12	82.0	COG1345@1|root,COG1361@1|root,COG1520@1|root,COG2866@1|root,COG3291@1|root,COG3391@1|root,COG4733@1|root,COG1345@2|Bacteria,COG1361@2|Bacteria,COG1520@2|Bacteria,COG2866@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia	976|Bacteroidetes	DZ	adhesin AidA-related	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Gal_Lectin,HYR,Laminin_G_3,SprB,TSP_3
HFD1_k127_2240367_8	234267.Acid_3641	2.642e-88	293.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase
HFD1_k127_2240367_12	234267.Acid_3641	9.633e-38	151.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase
HFD1_k127_2240367_0	234267.Acid_5953	0.0	1337.0	28I2Y@1|root,2Z86X@2|Bacteria	2|Bacteria	-	-	yetA	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2240367_13	234267.Acid_4847	1.059e-11	70.0	COG5434@1|root,COG5434@2|Bacteria,3Y2SR@57723|Acidobacteria	57723|Acidobacteria	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
HFD1_k127_2240367_10	234267.Acid_3659	2.084e-66	245.0	2DBK2@1|root,2Z9Q1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2240367_9	648996.Theam_1600	5.81e-87	314.0	COG0001@1|root,COG0001@2|Bacteria,2G3VU@200783|Aquificae	200783|Aquificae	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD1_k127_2240367_2	1267535.KB906767_gene2719	8.428e-201	647.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.1.1.102	ko:K06978,ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	AXE1,Big_5,LTD,Peptidase_S9,Tannase
HFD1_k127_2240367_4	143224.JQMD01000002_gene121	1.768e-136	478.0	COG3119@1|root,COG3119@2|Bacteria,4NE6V@976|Bacteroidetes,1HZ00@117743|Flavobacteriia	976|Bacteroidetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_2240367_5	1267535.KB906767_gene3885	5.601e-136	441.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	204432|Acidobacteriia	T	Osmosensitive K channel His kinase sensor	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	KdpD,Usp
HFD1_k127_2240367_7	1267535.KB906767_gene3886	1.561e-91	313.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	1267535.KB906767_gene3886|-	T	Osmosensitive K channel His kinase sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2240367_11	1267535.KB906767_gene3881	1.983e-59	220.0	COG2156@1|root,COG2156@2|Bacteria,3Y49M@57723|Acidobacteria,2JJ0W@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HFD1_k127_2240367_1	1267535.KB906767_gene3882	0.0	1087.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HFD1_k127_2240367_3	1267535.KB906767_gene3883	1.103e-190	600.0	COG2060@1|root,COG2060@2|Bacteria,3Y2YP@57723|Acidobacteria,2JIFM@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HFD1_k127_224485_0	234267.Acid_7252	1.888e-191	605.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_224485_5	47763.JNZA01000070_gene4155	4.867e-69	265.0	COG3391@1|root,COG3391@2|Bacteria,2H4SV@201174|Actinobacteria	201174|Actinobacteria	MU	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
HFD1_k127_224485_10	234267.Acid_2904	5.377e-18	100.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
HFD1_k127_224485_12	1070319.CAGGBEG34_440008	0.0004424	45.0	COG3514@1|root,COG3514@2|Bacteria,1N6WF@1224|Proteobacteria,2VVH8@28216|Betaproteobacteria,1K930@119060|Burkholderiaceae	28216|Betaproteobacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
HFD1_k127_224485_2	234267.Acid_4805	4.326e-129	416.0	COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria	57723|Acidobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HFD1_k127_224485_9	234267.Acid_4806	2.165e-22	108.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF836,Thioredoxin,Thioredoxin_3
HFD1_k127_224485_4	234267.Acid_4807	2.584e-82	278.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria	57723|Acidobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD1_k127_224485_1	234267.Acid_4808	2.515e-165	535.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
HFD1_k127_224485_8	234267.Acid_0980	5.243e-42	177.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,CHAT,LCAT
HFD1_k127_224485_6	1340493.JNIF01000003_gene2146	2.224e-49	182.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_224485_3	234267.Acid_7679	1.27e-83	308.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_2248142_0	234267.Acid_1993	6.859e-132	427.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD1_k127_2248142_1	234267.Acid_1995	2.395e-14	85.0	COG3023@1|root,COG3023@2|Bacteria	2|Bacteria	V	N-Acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K11066,ko:K12287	-	-	-	-	ko00000,ko01000,ko01011,ko02044	-	-	-	Amidase_2
HFD1_k127_2265599_1	234267.Acid_0669	1.186e-86	290.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_2265599_0	401053.AciPR4_2699	3.084e-184	607.0	COG5029@1|root,COG5029@2|Bacteria	2|Bacteria	O	Prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
HFD1_k127_2265599_2	1266925.JHVX01000008_gene331	2.759e-06	55.0	2CHC4@1|root,2ZEVG@2|Bacteria,1P4GV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2269798_2	204669.Acid345_2412	9.327e-169	548.0	COG0642@1|root,COG0784@1|root,COG2172@1|root,COG0784@2|Bacteria,COG2172@2|Bacteria,COG2205@2|Bacteria,3Y30Z@57723|Acidobacteria,2JIHG@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_2269798_9	221288.JH992901_gene1439	2.407e-80	280.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,1G02S@1117|Cyanobacteria	1117|Cyanobacteria	KT	PFAM Stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,SpoIIE
HFD1_k127_2269798_11	335659.S23_24540	3.961e-48	176.0	COG2172@1|root,COG2172@2|Bacteria,1MZIF@1224|Proteobacteria,2UGY5@28211|Alphaproteobacteria,3K44W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2
HFD1_k127_2269798_10	402777.KB235903_gene1796	7.491e-50	180.0	COG1366@1|root,COG1366@2|Bacteria,1G60K@1117|Cyanobacteria,1HBA6@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Sulphate transporter antisigma-factor antagonist STAS	-	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD1_k127_2269798_6	1173027.Mic7113_3989	1.387e-100	346.0	COG1366@1|root,COG1366@2|Bacteria,1G1ZX@1117|Cyanobacteria,1H9T7@1150|Oscillatoriales	1117|Cyanobacteria	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	Protoglobin,RsbRD_N,STAS
HFD1_k127_2269798_7	234267.Acid_2348	1.034e-93	312.0	COG2952@1|root,COG2952@2|Bacteria,3Y55F@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
HFD1_k127_2269798_3	234267.Acid_2349	1.647e-166	533.0	COG2271@1|root,COG2271@2|Bacteria,3Y7EW@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_2269798_13	234267.Acid_1315	1.143e-44	171.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_2269798_15	234267.Acid_2536	3.322e-13	77.0	COG2197@1|root,COG2202@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_16,GGDEF,GerE,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_2269798_5	234267.Acid_2350	1.678e-108	358.0	COG1573@1|root,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD1_k127_2269798_1	234267.Acid_2351	5.575e-200	629.0	COG0452@1|root,COG0452@2|Bacteria,3Y2QJ@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD1_k127_2269798_14	234267.Acid_2352	6.838e-37	140.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD1_k127_2269798_8	234267.Acid_2353	3.361e-87	292.0	COG0194@1|root,COG0194@2|Bacteria,3Y2JW@57723|Acidobacteria	57723|Acidobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HFD1_k127_2269798_4	234267.Acid_2354	1.239e-124	407.0	COG1561@1|root,COG1561@2|Bacteria,3Y2HQ@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HFD1_k127_2269798_0	234267.Acid_2355	1.931e-249	783.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD1_k127_2269798_12	234267.Acid_2356	1.063e-44	166.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD1_k127_2271542_0	234267.Acid_2721	4.14e-88	307.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD1_k127_2271542_1	1340493.JNIF01000003_gene4476	9.946e-41	163.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K07004,ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	ASH,CHU_C,DUF11,SGL
HFD1_k127_2318060_3	448385.sce0681	2.293e-36	154.0	COG1595@1|root,COG1595@2|Bacteria,1N3BR@1224|Proteobacteria	1224|Proteobacteria	K	rna polymerase sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_2318060_1	1183438.GKIL_3395	7.038e-157	532.0	COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria	1183438.GKIL_3395|-	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_2318060_4	1028800.RG540_CH05140	6.44e-19	94.0	COG2361@1|root,COG2361@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HFD1_k127_2318060_5	1282361.ABAC402_11530	2.453e-06	53.0	COG1669@1|root,COG1669@2|Bacteria,1N03X@1224|Proteobacteria,2UC9E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HFD1_k127_2318060_0	234267.Acid_1922	4.887e-255	790.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_2318060_2	234267.Acid_1921	1.064e-141	461.0	COG3852@1|root,COG3852@2|Bacteria,3Y9A1@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_232115_12	240015.ACP_1650	5.117e-41	154.0	COG1487@1|root,COG1487@2|Bacteria,3Y8P9@57723|Acidobacteria	57723|Acidobacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_232115_13	240015.ACP_1649	1.27e-16	85.0	29ARJ@1|root,2ZXR8@2|Bacteria,3Y8VA@57723|Acidobacteria	57723|Acidobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_232115_3	234267.Acid_0909	2.259e-118	387.0	COG0565@1|root,COG0565@2|Bacteria,3Y4F6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA rRNA methyltransferase, SpoU	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD1_k127_232115_8	234267.Acid_0908	1.597e-73	249.0	COG0102@1|root,COG0102@2|Bacteria,3Y4U5@57723|Acidobacteria	57723|Acidobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD1_k127_232115_9	234267.Acid_0907	1.595e-68	234.0	COG0103@1|root,COG0103@2|Bacteria,3Y4IK@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HFD1_k127_232115_1	234267.Acid_0906	7.486e-179	563.0	COG0052@1|root,COG0052@2|Bacteria,3Y3K2@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD1_k127_232115_6	234267.Acid_0905	4.131e-92	308.0	COG0264@1|root,COG0264@2|Bacteria,3Y3BT@57723|Acidobacteria	57723|Acidobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HFD1_k127_232115_2	234267.Acid_0904	2.688e-122	394.0	COG0528@1|root,COG0528@2|Bacteria,3Y2FI@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD1_k127_232115_11	370438.PTH_2358	3.125e-55	205.0	COG3527@1|root,COG3527@2|Bacteria,1V4AH@1239|Firmicutes,24FY1@186801|Clostridia	186801|Clostridia	Q	Alpha-acetolactate decarboxylase	alsD	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy,Peptidase_M15
HFD1_k127_232115_10	234267.Acid_4405	2.304e-59	209.0	COG5496@1|root,COG5496@2|Bacteria,3Y96F@57723|Acidobacteria	57723|Acidobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD1_k127_232115_4	234267.Acid_4406	3.248e-117	383.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HFD1_k127_232115_5	234267.Acid_4407	3.488e-93	310.0	COG3861@1|root,COG3861@2|Bacteria,3Y5WZ@57723|Acidobacteria	57723|Acidobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD1_k127_232115_7	1123060.JONP01000016_gene5455	2.874e-76	262.0	COG0546@1|root,COG0546@2|Bacteria,1RCPM@1224|Proteobacteria,2VF7A@28211|Alphaproteobacteria,2JVE8@204441|Rhodospirillales	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD1_k127_232115_0	234267.Acid_4250	6.191e-202	635.0	COG0644@1|root,COG0644@2|Bacteria,3Y5JJ@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Pyr_redox_2
HFD1_k127_2325485_0	234267.Acid_3947	5.83e-322	1004.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
HFD1_k127_2325485_3	643648.Slip_1404	7.605e-28	113.0	COG2442@1|root,COG2442@2|Bacteria,1VYG9@1239|Firmicutes,252G4@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD1_k127_2325485_2	429009.Adeg_0279	1.527e-31	128.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2325485_1	1121904.ARBP01000013_gene349	5.119e-142	462.0	COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_2325485_4	743525.TSC_c11750	7.201e-16	79.0	COG0730@1|root,COG0730@2|Bacteria,1WI3T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_2333745_7	234267.Acid_6695	1.107e-45	168.0	COG0745@1|root,COG0745@2|Bacteria,3Y933@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD1_k127_2333745_5	234267.Acid_7400	3.694e-55	203.0	COG2318@1|root,COG2318@2|Bacteria,3Y8J8@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_2333745_0	234267.Acid_7399	1.795e-252	785.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD1_k127_2333745_9	234267.Acid_0333	4.723e-20	91.0	COG1582@1|root,COG1582@2|Bacteria,3Y5M5@57723|Acidobacteria	57723|Acidobacteria	N	PFAM flagellar FlbD family protein	-	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
HFD1_k127_2333745_2	234267.Acid_0332	4.649e-117	383.0	COG1291@1|root,COG1291@2|Bacteria,3Y2VA@57723|Acidobacteria	57723|Acidobacteria	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HFD1_k127_2333745_3	234267.Acid_0331	2.046e-100	334.0	COG1360@1|root,COG1360@2|Bacteria,3Y4KZ@57723|Acidobacteria	57723|Acidobacteria	N	PFAM OmpA	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HFD1_k127_2333745_10	1246448.ANAZ01000046_gene4319	4.454e-12	76.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,Methyltransf_11,Methyltransf_25,Methyltransf_31
HFD1_k127_2333745_4	234267.Acid_6461	4.049e-95	315.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_2333745_1	234267.Acid_6462	3.335e-173	554.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4
HFD1_k127_2333745_6	234267.Acid_1320	5.447e-50	184.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	HTH_Crp_2,Na_sulph_symp,cNMP_binding
HFD1_k127_2333745_8	234267.Acid_3617	1.01e-36	145.0	COG4758@1|root,COG4758@2|Bacteria,3Y7Z2@57723|Acidobacteria	57723|Acidobacteria	S	N-terminal domain of toast_rack, DUF2154	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
HFD1_k127_234528_4	682795.AciX8_1161	9.014e-16	84.0	COG0175@1|root,COG0175@2|Bacteria,3Y36I@57723|Acidobacteria,2JHYJ@204432|Acidobacteriia	204432|Acidobacteriia	EH	Phosphoadenosine phosphosulfate reductase family	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD1_k127_234528_2	234267.Acid_6182	2.187e-157	503.0	COG3119@1|root,COG3119@2|Bacteria,3Y654@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_234528_0	234267.Acid_6181	0.0	1019.0	COG3379@1|root,COG3379@2|Bacteria,3Y7EC@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_234528_1	234267.Acid_6180	4.052e-296	921.0	COG3379@1|root,COG3379@2|Bacteria,3Y7CR@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_234528_3	234267.Acid_6179	4.45e-55	196.0	2DZX2@1|root,32VM6@2|Bacteria,3Y88Y@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2345290_0	234267.Acid_1353	0.0	1224.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_1353|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2345290_3	234267.Acid_2656	5.772e-96	348.0	COG0457@1|root,COG0457@2|Bacteria,3Y77J@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_11,TPR_16
HFD1_k127_2345290_2	234267.Acid_7075	1.672e-157	509.0	COG0037@1|root,COG0037@2|Bacteria,3Y2F2@57723|Acidobacteria	57723|Acidobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HFD1_k127_2345290_1	234267.Acid_7074	0.0	1089.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria	57723|Acidobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD1_k127_2345290_4	234267.Acid_7073	8.517e-21	95.0	COG0546@1|root,COG0546@2|Bacteria,3Y7CE@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD1_k127_235527_1	234267.Acid_0138	6.148e-102	358.0	COG3806@1|root,COG3806@2|Bacteria,3Y5HQ@57723|Acidobacteria	57723|Acidobacteria	T	Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_235527_2	234267.Acid_0137	1.034e-79	269.0	COG1595@1|root,COG1595@2|Bacteria,3Y5ME@57723|Acidobacteria	57723|Acidobacteria	K	region 4 type 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_235527_0	234267.Acid_0136	6.091e-135	438.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD1_k127_235527_3	234267.Acid_3933	2.22e-51	196.0	COG4219@1|root,COG4219@2|Bacteria,3Y9A7@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_235527_6	626418.bglu_2g16630	2.635e-08	58.0	2CU57@1|root,32SUP@2|Bacteria,1N68C@1224|Proteobacteria,2WFCX@28216|Betaproteobacteria,1KDVX@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_235527_5	439235.Dalk_4682	3.244e-14	76.0	2BI4W@1|root,330YN@2|Bacteria,1N1P2@1224|Proteobacteria,431G3@68525|delta/epsilon subdivisions,2WWBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Killing trait	-	-	-	-	-	-	-	-	-	-	-	-	RebB
HFD1_k127_235527_4	626418.bglu_2g16710	4.479e-16	80.0	2BI4W@1|root,32AFP@2|Bacteria,1RKZI@1224|Proteobacteria,2W36C@28216|Betaproteobacteria,1KI0G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Killing trait	-	-	-	-	-	-	-	-	-	-	-	-	RebB
HFD1_k127_2422051_1	1267535.KB906767_gene1724	8.804e-137	449.0	COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_2422051_7	234267.Acid_7128	3.006e-12	71.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	57723|Acidobacteria	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2422051_3	1163617.SCD_n01352	9.439e-45	186.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria	28216|Betaproteobacteria	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HFD1_k127_2422051_8	10141.ENSCPOP00000006253	5.354e-06	55.0	COG0666@1|root,KOG4177@2759|Eukaryota,38G40@33154|Opisthokonta,3BDYR@33208|Metazoa,3CSE6@33213|Bilateria,48CFE@7711|Chordata,48XIX@7742|Vertebrata,3JDK3@40674|Mammalia,35M6Z@314146|Euarchontoglires,4Q04U@9989|Rodentia	33208|Metazoa	M	ankyrin repeat and LEM domain-containing protein 1	ANKLE1	GO:0000003,GO:0000018,GO:0000019,GO:0000280,GO:0002682,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003824,GO:0004518,GO:0004519,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005637,GO:0005639,GO:0005737,GO:0006139,GO:0006611,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0006997,GO:0006998,GO:0007049,GO:0007059,GO:0007127,GO:0008104,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010256,GO:0010605,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019866,GO:0022402,GO:0022414,GO:0031090,GO:0031224,GO:0031229,GO:0031300,GO:0031301,GO:0031323,GO:0031324,GO:0031490,GO:0031965,GO:0031967,GO:0031975,GO:0033036,GO:0034397,GO:0034398,GO:0034613,GO:0034641,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044446,GO:0044453,GO:0044464,GO:0044821,GO:0045132,GO:0045141,GO:0045143,GO:0045184,GO:0045595,GO:0045910,GO:0045934,GO:0045950,GO:0046483,GO:0046907,GO:0048285,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050000,GO:0050789,GO:0050793,GO:0050794,GO:0051052,GO:0051053,GO:0051168,GO:0051169,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051239,GO:0051276,GO:0051303,GO:0051321,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0060255,GO:0061024,GO:0061982,GO:0065007,GO:0070192,GO:0070197,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090220,GO:0090304,GO:0090305,GO:0097159,GO:0097240,GO:0098813,GO:0140013,GO:1901360,GO:1901363,GO:1901532,GO:1903046,GO:1903706,GO:1905453,GO:1905456,GO:2000026,GO:2001020,GO:2001022	-	ko:K21411	-	-	-	-	ko00000,ko03400	-	-	-	Ank_2,LEM
HFD1_k127_2422051_4	880073.Calab_0094	1.736e-42	175.0	COG0526@1|root,COG0526@2|Bacteria,2NRMM@2323|unclassified Bacteria	2|Bacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
HFD1_k127_2422051_6	1121939.L861_13805	4.693e-25	107.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,1SBZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_2422051_0	1125863.JAFN01000001_gene2796	7.892e-178	576.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
HFD1_k127_2422051_5	443144.GM21_2851	4.082e-25	111.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria,43UPC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Rieske [2Fe-2S] domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD1_k127_2422051_2	1125863.JAFN01000001_gene2794	1.382e-50	184.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD1_k127_2422579_3	436229.JOEH01000007_gene3927	9.09e-08	54.0	COG0645@1|root,COG0645@2|Bacteria,2IKMM@201174|Actinobacteria	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HFD1_k127_2422579_4	1267534.KB906754_gene3162	7.406e-07	56.0	COG0577@1|root,COG0577@2|Bacteria,3Y6DE@57723|Acidobacteria,2JM90@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2422579_1	234267.Acid_2632	1.876e-183	585.0	COG0737@1|root,COG0737@2|Bacteria,3Y82P@57723|Acidobacteria	57723|Acidobacteria	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
HFD1_k127_2422579_0	234267.Acid_4075	6.955e-253	795.0	COG4993@1|root,COG4993@2|Bacteria,3Y6WZ@57723|Acidobacteria	57723|Acidobacteria	C	Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD1_k127_2422579_2	240016.ABIZ01000001_gene5926	2.356e-74	265.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
HFD1_k127_2423135_1	234267.Acid_0197	1.708e-41	158.0	COG5616@1|root,COG5616@2|Bacteria,3Y4NN@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2423135_2	1382359.JIAL01000001_gene2555	1.019e-24	110.0	COG3254@1|root,COG3254@2|Bacteria,3Y5KE@57723|Acidobacteria,2JNUN@204432|Acidobacteriia	204432|Acidobacteriia	S	L-rhamnose mutarotase	-	-	-	-	-	-	-	-	-	-	-	-	rhaM
HFD1_k127_2423135_0	234267.Acid_5958	4.102e-178	561.0	COG4952@1|root,COG4952@2|Bacteria,3Y3J5@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Xylose isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_2428798_1	234267.Acid_5847	1.406e-212	687.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2428798_4	234267.Acid_5846	9.463e-51	181.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_2428798_0	234267.Acid_4431	2.502e-274	880.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_2428798_3	1122604.JONR01000045_gene2508	3.717e-123	405.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RPIE@1236|Gammaproteobacteria,1X4MD@135614|Xanthomonadales	135614|Xanthomonadales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_2428798_2	234267.Acid_1343	1.173e-147	492.0	COG0673@1|root,COG0673@2|Bacteria,3Y6Z2@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_2428798_6	1123277.KB893172_gene490	1.839e-47	193.0	2C5JH@1|root,32WG0@2|Bacteria,4P1NG@976|Bacteroidetes,47TH0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2428798_5	234267.Acid_5885	4.522e-49	179.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HFD1_k127_2436535_5	234267.Acid_7758	5.036e-101	334.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2436535_0	234267.Acid_7288	3.167e-236	737.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,3Y4NX@57723|Acidobacteria	57723|Acidobacteria	GM	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD1_k127_2436535_6	234267.Acid_7287	1.159e-97	322.0	COG0461@1|root,COG0461@2|Bacteria,3Y6JQ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosyl transferase domain	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD1_k127_2436535_7	234267.Acid_7286	2.104e-82	284.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD1_k127_2436535_2	234267.Acid_7285	5.906e-146	473.0	COG4585@1|root,COG4585@2|Bacteria,3Y8CF@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD1_k127_2436535_4	234267.Acid_7284	8.911e-117	394.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
HFD1_k127_2436535_1	234267.Acid_7283	1.113e-191	620.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria	57723|Acidobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_2436535_3	378806.STAUR_6357	4.812e-129	437.0	COG0464@1|root,COG0464@2|Bacteria,1RCHW@1224|Proteobacteria,42Z41@68525|delta/epsilon subdivisions,2WU9F@28221|Deltaproteobacteria,2YUT7@29|Myxococcales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD1_k127_2436535_12	1242864.D187_006513	1.891e-07	63.0	2EDTI@1|root,337NU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2436535_8	868595.Desca_1042	4.621e-61	226.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,260GU@186807|Peptococcaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
HFD1_k127_2436535_10	1382356.JQMP01000004_gene134	5.656e-36	147.0	COG0600@1|root,COG0600@2|Bacteria,2G72A@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD1_k127_2436535_9	1122176.KB903554_gene3842	1.888e-46	188.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,4NM1E@976|Bacteroidetes,1IWA5@117747|Sphingobacteriia	976|Bacteroidetes	MP	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
HFD1_k127_2436535_13	518766.Rmar_0090	5.964e-07	60.0	COG1842@1|root,COG1842@2|Bacteria,4P0T5@976|Bacteroidetes,1FIR5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HFD1_k127_2453738_6	861299.J421_1453	9.077e-34	135.0	COG0652@1|root,COG0652@2|Bacteria,1ZUVW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
HFD1_k127_2453738_2	234267.Acid_1294	1.985e-195	623.0	COG0737@1|root,COG0737@2|Bacteria,3Y66D@57723|Acidobacteria	57723|Acidobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HFD1_k127_2453738_3	234267.Acid_1295	1.203e-169	541.0	COG0457@1|root,COG0457@2|Bacteria,3Y2VC@57723|Acidobacteria	57723|Acidobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HFD1_k127_2453738_7	234267.Acid_1296	1.5e-21	98.0	28VY2@1|root,2ZHZA@2|Bacteria,3Y90R@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2453738_4	234267.Acid_1297	1.312e-150	483.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD1_k127_2453738_1	234267.Acid_1298	9.699e-214	692.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD1_k127_2453738_0	234267.Acid_1308	1.533e-260	807.0	COG2308@1|root,COG2308@2|Bacteria,3Y6VU@57723|Acidobacteria	57723|Acidobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2453738_5	234267.Acid_1392	1.061e-127	413.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	-	-	3.6.3.38,3.6.3.40	ko:K09689,ko:K09691,ko:K09693	ko02010,map02010	M00249,M00250,M00251	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103,3.A.1.104	-	-	ABC_tran,LysM,Wzt_C
HFD1_k127_2469041_2	640512.BC1003_5743	1.339e-08	56.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2VIJS@28216|Betaproteobacteria,1K156@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	BON,OmpA
HFD1_k127_2469041_0	1123257.AUFV01000014_gene3445	5.873e-67	246.0	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria,1X5D2@135614|Xanthomonadales	135614|Xanthomonadales	M	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA,TSP_3
HFD1_k127_2469041_1	379066.GAU_0195	3.297e-21	96.0	COG0111@1|root,COG0111@2|Bacteria,1ZSVM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD1_k127_246980_1	639283.Snov_0188	3.334e-41	158.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3EYRF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD1_k127_246980_0	1121861.KB899939_gene3759	3.423e-94	317.0	COG4126@1|root,COG4126@2|Bacteria	2|Bacteria	E	flavin adenine dinucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
HFD1_k127_246980_3	1100720.ALKN01000007_gene3069	0.0006003	52.0	2BSVZ@1|root,32MZJ@2|Bacteria,1MZ0N@1224|Proteobacteria,2VTGA@28216|Betaproteobacteria,4AET4@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_246980_2	543728.Vapar_5677	4.118e-20	99.0	COG3181@1|root,COG3181@2|Bacteria,1MXC0@1224|Proteobacteria,2VKN6@28216|Betaproteobacteria,4A9T4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD1_k127_2476391_0	243231.GSU2601	1.067e-74	259.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,42PJA@68525|delta/epsilon subdivisions,2WMG0@28221|Deltaproteobacteria,43TUT@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
HFD1_k127_2476391_2	1123322.KB904656_gene739	1.84e-26	126.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,DUF4214,FG-GAP,HemolysinCabind,VCBS
HFD1_k127_2476391_1	1267535.KB906767_gene4499	3.223e-53	203.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_2476391_3	234267.Acid_6547	9.711e-22	100.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD1_k127_2477734_1	234267.Acid_1007	2.684e-52	188.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria	57723|Acidobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_2477734_0	401053.AciPR4_0162	6.651e-183	589.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD1_k127_2477734_2	234267.Acid_1009	1.964e-39	151.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria	57723|Acidobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HFD1_k127_2481178_1	234267.Acid_3254	2.538e-164	528.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_2481178_0	234267.Acid_3255	5.778e-178	572.0	COG0282@1|root,COG0282@2|Bacteria,3Y6AP@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	-	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HFD1_k127_2481178_2	1267535.KB906767_gene457	2.66e-43	167.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2482395_6	1122605.KB893625_gene1958	3.423e-47	174.0	COG4409@1|root,COG4409@2|Bacteria,4NJNK@976|Bacteroidetes,1IWRN@117747|Sphingobacteriia	976|Bacteroidetes	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HFD1_k127_2482395_1	234267.Acid_0387	1.662e-117	390.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HFD1_k127_2482395_5	1090318.ATTI01000001_gene512	4.832e-62	230.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.2.26	ko:K00771	ko00532,ko00534,ko01100,map00532,map00534,map01100	M00057	R05925	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT14	-	Branch
HFD1_k127_2482395_0	234267.Acid_3219	5.295e-188	626.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2482395_3	1267535.KB906767_gene3658	3.176e-72	254.0	COG1216@1|root,COG1216@2|Bacteria,3Y6F6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_2482395_4	1267535.KB906767_gene3657	7.138e-69	241.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Anp1,Gly_transf_sug,Glycos_transf_2,Glyphos_transf
HFD1_k127_2482395_2	234267.Acid_5471	4.118e-114	393.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6C0@57723|Acidobacteria	57723|Acidobacteria	KLTU	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD1_k127_2483285_0	234267.Acid_3590	2.258e-282	882.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF11,DUF4384,Flg_new,TonB_dep_Rec
HFD1_k127_2483285_9	234267.Acid_7833	5.469e-80	272.0	COG1309@1|root,COG1309@2|Bacteria,3Y4QT@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD1_k127_2483285_5	234267.Acid_3177	7.292e-132	424.0	COG4137@1|root,COG4137@2|Bacteria,3Y9FX@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HFD1_k127_2483285_2	234267.Acid_3178	5.686e-225	709.0	COG0373@1|root,COG0373@2|Bacteria,3Y3DQ@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HFD1_k127_2483285_3	234267.Acid_3179	2.299e-140	452.0	COG0181@1|root,COG0181@2|Bacteria,3Y3RY@57723|Acidobacteria	57723|Acidobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD1_k127_2483285_1	234267.Acid_3181	7.096e-246	771.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3Y4W1@57723|Acidobacteria	57723|Acidobacteria	H	synthase	-	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HFD1_k127_2483285_7	234267.Acid_3182	6.259e-93	308.0	COG0572@1|root,COG0572@2|Bacteria,3Y4EI@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HFD1_k127_2483285_4	234267.Acid_3420	2.02e-132	429.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	2|Bacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HFD1_k127_2483285_8	234267.Acid_3419	1.103e-87	299.0	COG1040@1|root,COG1040@2|Bacteria,3Y4SY@57723|Acidobacteria	57723|Acidobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HFD1_k127_2483285_6	234267.Acid_3418	1.895e-96	317.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria	57723|Acidobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD1_k127_2483285_10	234267.Acid_3417	2.583e-21	98.0	2EQAC@1|root,33HWH@2|Bacteria,3Y5W6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2493602_1	234267.Acid_7352	1.734e-190	612.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_10,PAS_4
HFD1_k127_2493602_0	234267.Acid_7351	3.68e-243	756.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_2493602_2	1121957.ATVL01000006_gene2808	1.46e-169	543.0	COG3391@1|root,COG5297@1|root,COG3391@2|Bacteria,COG5297@2|Bacteria,4PKPX@976|Bacteroidetes,47NGZ@768503|Cytophagia	976|Bacteroidetes	G	Fg-gap repeat	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
HFD1_k127_2502132_1	234267.Acid_2862	1.395e-155	496.0	COG0577@1|root,COG0577@2|Bacteria,3Y3ZQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_2502132_4	1267535.KB906767_gene3311	1.169e-12	78.0	2DKRJ@1|root,30AGT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
HFD1_k127_2502132_0	1267535.KB906767_gene4459	1.104e-177	584.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_2502132_3	234267.Acid_4717	9.096e-31	123.0	COG1605@1|root,COG1605@2|Bacteria	2|Bacteria	E	Chorismate mutase	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
HFD1_k127_2502132_2	1340493.JNIF01000003_gene3273	4.172e-44	171.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
HFD1_k127_2505720_3	398767.Glov_3330	1.267e-06	53.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolases of the beta-lactamase superfamily I	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HFD1_k127_2505720_2	313589.JNB_00200	2.258e-39	150.0	COG3427@1|root,COG3427@2|Bacteria,2ISBF@201174|Actinobacteria,4FH30@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD1_k127_2505720_0	234267.Acid_0720	6.397e-139	451.0	COG2333@1|root,COG2333@2|Bacteria,3Y323@57723|Acidobacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_2505720_1	234267.Acid_0722	4.161e-55	218.0	COG4818@1|root,COG4818@2|Bacteria,3Y8T8@57723|Acidobacteria	57723|Acidobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2511972_2	134676.ACPL_2641	4.039e-11	65.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	yrgI	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HFD1_k127_2511972_0	1304880.JAGB01000001_gene534	0.0	1066.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia	186801|Clostridia	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD1_k127_2511972_1	1499967.BAYZ01000090_gene4961	1.645e-32	129.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_2523709_1	448385.sce6976	3.266e-40	162.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
HFD1_k127_2523709_0	1340493.JNIF01000004_gene88	0.0	1212.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_2525578_4	234267.Acid_6449	5.291e-34	141.0	COG2510@1|root,COG2510@2|Bacteria,3Y549@57723|Acidobacteria	57723|Acidobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	EamA,TMEM234
HFD1_k127_2525578_3	234267.Acid_6448	1.921e-47	173.0	COG2510@1|root,COG2510@2|Bacteria,3Y4SP@57723|Acidobacteria	57723|Acidobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_2525578_0	234267.Acid_7504	1.038e-297	915.0	COG1032@1|root,COG1032@2|Bacteria,3Y2QU@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_2525578_2	234267.Acid_7505	1.482e-70	246.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4367,LolA,LolA_like
HFD1_k127_2525578_5	1123226.KB899287_gene3622	2.533e-08	65.0	COG3861@1|root,COG3861@2|Bacteria,1V5RZ@1239|Firmicutes,4HHAU@91061|Bacilli,26SHD@186822|Paenibacillaceae	91061|Bacilli	S	Heat induced stress protein YflT	-	-	-	-	-	-	-	-	-	-	-	-	YflT
HFD1_k127_2525578_1	234267.Acid_5714	1.775e-254	799.0	COG4206@1|root,COG4206@2|Bacteria,3Y63R@57723|Acidobacteria	57723|Acidobacteria	H	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_255710_13	886293.Sinac_0271	2.156e-28	117.0	COG1073@1|root,COG1073@2|Bacteria,2IYQ5@203682|Planctomycetes	203682|Planctomycetes	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD1_k127_255710_17	1094489.BAnh1_00610	3.535e-08	57.0	COG2336@1|root,COG2336@2|Bacteria,1N4WH@1224|Proteobacteria,2UFHW@28211|Alphaproteobacteria,48U9I@772|Bartonellaceae	28211|Alphaproteobacteria	T	SpoVT AbrB domain-containing protein	pemI	-	-	ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HFD1_k127_255710_1	234267.Acid_0177	3.342e-308	949.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD1_k127_255710_4	1340493.JNIF01000004_gene740	1.935e-178	563.0	COG0059@1|root,COG0059@2|Bacteria,3Y34M@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HFD1_k127_255710_10	234267.Acid_0179	1.711e-87	293.0	COG0440@1|root,COG0440@2|Bacteria,3Y580@57723|Acidobacteria	57723|Acidobacteria	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HFD1_k127_255710_0	234267.Acid_0180	0.0	1048.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria	57723|Acidobacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_255710_14	234267.Acid_7394	8.822e-20	94.0	COG3345@1|root,COG3345@2|Bacteria,3Y8BZ@57723|Acidobacteria	57723|Acidobacteria	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
HFD1_k127_255710_15	493475.GARC_0143	5.615e-11	72.0	COG1404@1|root,COG3227@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Zinc metalloprotease (Elastase)	prt1	-	3.4.24.28	ko:K01400	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,PLN_propep,Peptidase_M4,Peptidase_M4_C
HFD1_k127_255710_12	1463825.JNXC01000006_gene2153	4.864e-55	202.0	COG2304@1|root,COG4257@1|root,COG2304@2|Bacteria,COG4257@2|Bacteria,2IDJM@201174|Actinobacteria,4E2D1@85010|Pseudonocardiales	201174|Actinobacteria	V	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
HFD1_k127_255710_3	234267.Acid_7394	3.993e-287	898.0	COG3345@1|root,COG3345@2|Bacteria,3Y8BZ@57723|Acidobacteria	57723|Acidobacteria	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
HFD1_k127_255710_8	234267.Acid_7395	5.248e-147	469.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria	57723|Acidobacteria	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD1_k127_255710_11	234267.Acid_7396	3.438e-67	235.0	COG1544@1|root,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808,ko:K05809	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HFD1_k127_255710_2	234267.Acid_7397	9.44e-289	892.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD1_k127_255710_6	234267.Acid_7398	1.342e-175	560.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD1_k127_255710_18	1267534.KB906757_gene1000	5.268e-06	57.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_255710_16	234267.Acid_3583	3.393e-08	57.0	COG1629@1|root,COG1629@2|Bacteria,3Y78S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_255710_7	234267.Acid_1598	6.522e-167	530.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmD	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
HFD1_k127_255710_5	234267.Acid_1600	3.496e-177	570.0	COG1450@1|root,COG1450@2|Bacteria,3Y6Z6@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
HFD1_k127_255710_9	234267.Acid_1601	8.399e-109	385.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD1_k127_255710_19	1408427.JADB01000006_gene134	3.364e-05	46.0	2DTS4@1|root,33MFD@2|Bacteria,1PTGB@1224|Proteobacteria,2V5BU@28211|Alphaproteobacteria,48UEV@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2559960_1	143224.JQMD01000002_gene4018	0.0002557	54.0	2BZ4R@1|root,3344Z@2|Bacteria,4NX0J@976|Bacteroidetes,1I7U3@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2559960_0	234267.Acid_4381	6.218e-117	381.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_2563758_1	717606.PaecuDRAFT_2033	4.667e-135	459.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HFD1_k127_2563758_6	663278.Ethha_1284	5.048e-12	73.0	COG0558@1|root,COG0558@2|Bacteria,1V93Y@1239|Firmicutes,24JNH@186801|Clostridia,3WSFG@541000|Ruminococcaceae	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD1_k127_2563758_0	1382359.JIAL01000001_gene1021	6.265e-203	645.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD1_k127_2563758_3	1267535.KB906767_gene2896	5.296e-65	227.0	COG0723@1|root,COG0723@2|Bacteria,3Y5N6@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD1_k127_2563758_2	234267.Acid_2927	8.702e-120	389.0	COG0437@1|root,COG0437@2|Bacteria,3Y4QF@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11
HFD1_k127_2563758_4	234267.Acid_2928	8.03e-26	106.0	COG0243@1|root,COG0243@2|Bacteria,3Y2HB@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD1_k127_2569580_2	234267.Acid_6992	1.783e-100	331.0	COG2183@1|root,COG2183@2|Bacteria,3Y2QM@57723|Acidobacteria	57723|Acidobacteria	K	SMART Resolvase, RNase H domain protein fold	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HFD1_k127_2569580_1	234267.Acid_6753	2.492e-111	367.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria,3Y4DW@57723|Acidobacteria	2|Bacteria	T	Histidine kinase-like ATPase domain	rsbW	-	2.7.11.1,3.4.21.53	ko:K01338,ko:K04757,ko:K06379,ko:K08282,ko:K17752	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko03021	-	-	-	HATPase_c_2,HTH_8,Response_reg
HFD1_k127_2569580_0	234267.Acid_6754	1.478e-154	503.0	29UCR@1|root,30FP6@2|Bacteria,3Y4J8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2569580_3	234267.Acid_4945	3.537e-85	284.0	2B33H@1|root,31VR5@2|Bacteria,3Y819@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2574833_12	234267.Acid_7090	9.509e-21	93.0	COG3384@1|root,COG3384@2|Bacteria,3Y57M@57723|Acidobacteria	57723|Acidobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HFD1_k127_2574833_0	234267.Acid_1492	3.376e-310	954.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria	57723|Acidobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD1_k127_2574833_10	234267.Acid_5079	2.385e-57	208.0	2DRI2@1|root,33BVT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2574833_5	1267535.KB906767_gene5363	6.148e-108	365.0	COG3547@1|root,COG3547@2|Bacteria,3Y6PK@57723|Acidobacteria	57723|Acidobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD1_k127_2574833_7	234267.Acid_0055	9.819e-92	308.0	2AY4N@1|root,31Q6J@2|Bacteria,3Y7H6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2574833_8	1267535.KB906767_gene3533	6.98e-75	258.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HFD1_k127_2574833_1	234267.Acid_0053	1.201e-239	758.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD1_k127_2574833_2	234267.Acid_0052	2.574e-230	733.0	COG0527@1|root,COG0527@2|Bacteria,3Y62M@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,Homoserine_dh,NAD_binding_3
HFD1_k127_2574833_6	234267.Acid_0051	2.771e-105	346.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD1_k127_2574833_9	234267.Acid_0607	1.237e-58	205.0	COG3824@1|root,COG3824@2|Bacteria,3Y8W9@57723|Acidobacteria	57723|Acidobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HFD1_k127_2574833_4	234267.Acid_7368	2.309e-137	444.0	COG2220@1|root,COG2220@2|Bacteria,3Y2TV@57723|Acidobacteria	57723|Acidobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD1_k127_2574833_3	234267.Acid_3778	1.337e-151	511.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2574833_11	234267.Acid_3620	7.324e-44	162.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_2587606_11	1267535.KB906767_gene228	5.03e-42	179.0	COG3420@1|root,COG3420@2|Bacteria,3Y67Z@57723|Acidobacteria	57723|Acidobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HFD1_k127_2587606_2	234267.Acid_4272	4.195e-175	578.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2587606_0	234267.Acid_4968	0.0	1054.0	COG0308@1|root,COG0308@2|Bacteria,3Y31F@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD1_k127_2587606_4	234267.Acid_4970	8.502e-118	385.0	COG0179@1|root,COG0179@2|Bacteria,3Y4QZ@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD1_k127_2587606_7	1267535.KB906767_gene3579	3.445e-81	285.0	COG1312@1|root,COG1312@2|Bacteria,3Y6WX@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HFD1_k127_2587606_3	861299.J421_6259	2.739e-157	531.0	COG0366@1|root,COG0366@2|Bacteria,1ZUGN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Cyclomaltodextrinase, N-terminal	-	-	3.2.1.135	ko:K21575	-	-	-	-	ko00000,ko01000	-	GH13	-	Alpha-amylase,Cyc-maltodext_N
HFD1_k127_2587606_1	234267.Acid_2655	6.25e-227	709.0	COG3669@1|root,COG3669@2|Bacteria,3Y3XG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HFD1_k127_2587606_10	1123508.JH636442_gene4254	4.949e-46	169.0	COG1090@1|root,COG1090@2|Bacteria,2IYWK@203682|Planctomycetes	203682|Planctomycetes	S	nucleoside-diphosphate sugar epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HFD1_k127_2587606_6	1267534.KB906759_gene1968	5.005e-82	280.0	COG1090@1|root,COG1090@2|Bacteria,3Y2PB@57723|Acidobacteria,2JI82@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HFD1_k127_2587606_9	234267.Acid_0961	9.313e-59	207.0	COG4276@1|root,COG4276@2|Bacteria,3Y521@57723|Acidobacteria	57723|Acidobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2587606_5	234267.Acid_0199	1.745e-86	294.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	hpcH	-	2.7.7.38,4.1.2.20,4.1.2.52	ko:K00979,ko:K01630,ko:K02510	ko00053,ko00350,ko00540,ko01100,ko01120,map00053,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R02754,R03277,R03351,R11396	RC00152,RC00307,RC00435,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
HFD1_k127_2603094_3	234267.Acid_5751	2.508e-55	195.0	2DB8V@1|root,2Z7SX@2|Bacteria	2|Bacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD1_k127_2603094_0	234267.Acid_5750	4.851e-273	856.0	COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD1_k127_2603094_4	234267.Acid_4378	9.871e-53	199.0	COG2322@1|root,COG2322@2|Bacteria,3Y5H4@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HFD1_k127_2603094_2	234267.Acid_4379	3.496e-63	233.0	COG1999@1|root,COG1999@2|Bacteria,3Y855@57723|Acidobacteria	57723|Acidobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD1_k127_2603094_1	234267.Acid_4380	1.072e-118	387.0	COG0842@1|root,COG0842@2|Bacteria,3Y2S4@57723|Acidobacteria	57723|Acidobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD1_k127_2603094_5	204669.Acid345_2220	1.966e-36	140.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria,2JIPJ@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_2605200_0	1278073.MYSTI_03564	0.0	1191.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_2605200_3	234267.Acid_4266	2.679e-49	184.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_2605200_5	861299.J421_5889	1.68e-31	129.0	2DSP1@1|root,33GVU@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
HFD1_k127_2605200_6	861299.J421_5888	1.154e-26	112.0	COG3655@1|root,COG3655@2|Bacteria	2|Bacteria	K	Transcriptional regulator	yozG	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
HFD1_k127_2605200_4	204669.Acid345_4011	8.693e-40	152.0	2ED19@1|root,336Y7@2|Bacteria,3Y95N@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2605200_2	1440053.JOEI01000029_gene4489	1.77e-50	191.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_11,AAA_12,PLDc_2,Sulfotransfer_3
HFD1_k127_2605200_1	1267533.KB906735_gene4931	4.394e-164	534.0	COG1032@1|root,COG1032@2|Bacteria,3Y7D8@57723|Acidobacteria,2JMKA@204432|Acidobacteriia	204432|Acidobacteriia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_2611729_9	1328313.DS2_04810	5.061e-05	52.0	2EXT0@1|root,33R29@2|Bacteria,1NTDZ@1224|Proteobacteria,1SJWT@1236|Gammaproteobacteria,46AAM@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HFD1_k127_2611729_6	1045009.AFXQ01000001_gene2272	3.055e-31	138.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,1WCEU@1268|Micrococcaceae	201174|Actinobacteria	G	Glycosyl transferases group 1	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_2611729_5	886293.Sinac_4406	9.325e-51	207.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD1_k127_2611729_1	489825.LYNGBM3L_21200	1.092e-180	591.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_2611729_2	489825.LYNGBM3L_21210	1.217e-167	549.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_2611729_0	489825.LYNGBM3L_21220	1.047e-302	963.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HFD1_k127_2611729_3	713587.THITH_00175	1.826e-124	407.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_2611729_4	1123508.JH636442_gene3961	3.106e-108	393.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
HFD1_k127_2611729_7	596152.DesU5LDRAFT_3334	6.407e-10	67.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,Response_reg
HFD1_k127_2628688_2	1040983.AXAE01000014_gene4980	8.434e-122	408.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,43QY1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
HFD1_k127_2628688_4	1379270.AUXF01000002_gene1719	3.048e-28	130.0	COG1044@1|root,COG1044@2|Bacteria	2|Bacteria	M	lipid A biosynthetic process	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HFD1_k127_2628688_3	1266925.JHVX01000006_gene2223	1.289e-59	219.0	COG0438@1|root,COG0438@2|Bacteria,1PJ7G@1224|Proteobacteria,2W2A5@28216|Betaproteobacteria,373ZR@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
HFD1_k127_2628688_0	234267.Acid_7732	0.0	1975.0	COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,3Y363@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12,5.99.1.2	ko:K03169,ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind
HFD1_k127_2628688_1	234267.Acid_6634	3.285e-139	447.0	COG0438@1|root,COG0438@2|Bacteria,3Y647@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_2653922_0	234267.Acid_0851	1.285e-167	541.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
HFD1_k127_2653922_1	234267.Acid_0852	1.319e-39	150.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HFD1_k127_2691449_2	1210884.HG799462_gene8307	2.838e-14	72.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD1_k127_2691449_0	926550.CLDAP_07830	3.753e-157	530.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_2691449_4	1267535.KB906767_gene1983	1.105e-07	55.0	COG0798@1|root,COG0798@2|Bacteria,3Y69M@57723|Acidobacteria,2JP2H@204432|Acidobacteriia	57723|Acidobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD1_k127_2691449_1	1163409.UUA_16108	2.457e-103	348.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1X40N@135614|Xanthomonadales	135614|Xanthomonadales	K	LacI family	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD1_k127_2691449_5	1198114.AciX9_0506	2.118e-07	59.0	COG1470@1|root,COG1629@1|root,COG1470@2|Bacteria,COG1629@2|Bacteria,3Y7DB@57723|Acidobacteria,2JM7W@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_269994_0	234267.Acid_5310	8.298e-221	688.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_269994_1	234267.Acid_5309	2.026e-209	654.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD1_k127_269994_3	234267.Acid_7033	6.519e-168	541.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD1_k127_269994_10	378806.STAUR_7790	4.347e-10	63.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HFD1_k127_269994_2	1267535.KB906767_gene4220	2.4e-184	587.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria,2JI43@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD1_k127_269994_7	682795.AciX8_4710	1.846e-43	179.0	2F66C@1|root,33YQF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_269994_9	1227499.C493_04126	1.628e-19	100.0	COG0463@1|root,arCOG01385@2157|Archaea,2Y7PB@28890|Euryarchaeota,23UIK@183963|Halobacteria	183963|Halobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_269994_6	234267.Acid_4573	1.747e-78	265.0	COG1396@1|root,COG1396@2|Bacteria,3Y4K9@57723|Acidobacteria	57723|Acidobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD1_k127_269994_5	234267.Acid_4572	1.072e-83	290.0	COG1585@1|root,COG1585@2|Bacteria,3Y4Y0@57723|Acidobacteria	57723|Acidobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_269994_4	234267.Acid_4571	4.43e-122	394.0	COG2268@1|root,COG2268@2|Bacteria,3Y3UJ@57723|Acidobacteria	57723|Acidobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HFD1_k127_269994_8	234267.Acid_4571	1.001e-26	109.0	COG2268@1|root,COG2268@2|Bacteria,3Y3UJ@57723|Acidobacteria	57723|Acidobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HFD1_k127_2703684_0	1317124.DW2_18909	9.038e-134	446.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,2TRZK@28211|Alphaproteobacteria,2XNUH@285107|Thioclava	28211|Alphaproteobacteria	L	Tn3 transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HFD1_k127_2704172_4	1267535.KB906767_gene4777	1.366e-23	102.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HATPase_c,HisKA_3
HFD1_k127_2704172_1	1267535.KB906767_gene4776	1.168e-70	249.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria,2JMQ5@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_2704172_3	861299.J421_1637	1.009e-24	106.0	2C1P2@1|root,32Y1F@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD1_k127_2704172_2	1242864.D187_004642	2.813e-26	119.0	COG0454@1|root,COG0456@2|Bacteria,1Q1ZZ@1224|Proteobacteria,42USA@68525|delta/epsilon subdivisions,2WQ2Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_2704172_0	204669.Acid345_3014	4.631e-114	391.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_2704172_5	1267535.KB906767_gene4441	9.74e-18	83.0	COG1225@1|root,COG1225@2|Bacteria,3Y3H3@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD1_k127_271537_7	234267.Acid_0836	1.977e-21	111.0	COG0437@1|root,COG0437@2|Bacteria,3Y65I@57723|Acidobacteria	57723|Acidobacteria	C	Formate dehydrogenase N, transmembrane	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Form-deh_trans
HFD1_k127_271537_0	234267.Acid_0837	0.0	1467.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3Y47M@57723|Acidobacteria	57723|Acidobacteria	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HFD1_k127_271537_5	234267.Acid_0838	4.86e-97	320.0	COG0243@1|root,COG0243@2|Bacteria,3Y7US@57723|Acidobacteria	57723|Acidobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4
HFD1_k127_271537_6	1267535.KB906767_gene1286	7.49e-40	158.0	COG2010@1|root,COG2010@2|Bacteria,3Y846@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_271537_2	234267.Acid_4577	9.282e-177	573.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_271537_3	234267.Acid_3735	4.894e-115	402.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AhpC-TSA,CarboxypepD_reg,PDZ_2,Plug,TonB_dep_Rec
HFD1_k127_271537_4	234267.Acid_3736	1.722e-97	337.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,DUF11,GSu_C4xC__C2xCH,SdrD_B
HFD1_k127_271537_1	234267.Acid_3859	1.117e-285	893.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria	2|Bacteria	T	histidine kinase A domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg
HFD1_k127_2731265_10	909663.KI867150_gene2770	7.822e-06	48.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HFD1_k127_2731265_5	234267.Acid_6504	2.979e-144	475.0	COG2982@1|root,COG2982@2|Bacteria,3Y2J8@57723|Acidobacteria	57723|Acidobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD1_k127_2731265_11	234267.Acid_3204	9.793e-06	48.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_2731265_0	234267.Acid_3204	0.0	1540.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_2731265_7	911239.CF149_19631	3.847e-121	405.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,1RMCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	yhbW	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD1_k127_2731265_4	234267.Acid_2764	9.756e-170	541.0	COG1524@1|root,COG1524@2|Bacteria,3Y7AY@57723|Acidobacteria	57723|Acidobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_2731265_8	373903.Hore_19060	4.088e-113	380.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3WA5V@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD1_k127_2731265_3	1267535.KB906767_gene337	2.009e-171	557.0	COG4289@1|root,COG4289@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2264)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2264
HFD1_k127_2731265_12	644966.Tmar_0713	0.0001721	50.0	COG1569@1|root,COG1569@2|Bacteria,1VCZ6@1239|Firmicutes,24Q32@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HFD1_k127_2731265_6	234267.Acid_3344	6.635e-137	443.0	COG0684@1|root,COG0684@2|Bacteria,3Y7HG@57723|Acidobacteria	57723|Acidobacteria	M	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD1_k127_2731265_1	234267.Acid_3343	1.349e-241	752.0	COG4948@1|root,COG4948@2|Bacteria,3Y61U@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_2731265_2	234267.Acid_3989	1.179e-194	630.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD1_k127_2731389_0	530564.Psta_1007	1.283e-127	420.0	COG0577@1|root,COG0577@2|Bacteria,2IWXH@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_2731389_1	588932.JHOF01000018_gene867	1.027e-27	128.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,2U76N@28211|Alphaproteobacteria,2KGJ2@204458|Caulobacterales	204458|Caulobacterales	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HFD1_k127_2731389_4	41431.PCC8801_1660	1.044e-11	67.0	COG1724@1|root,COG1724@2|Bacteria,1G9VQ@1117|Cyanobacteria,3KKAH@43988|Cyanothece	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_2731389_2	880073.Calab_2516	7.051e-23	99.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD1_k127_2731389_5	909663.KI867150_gene2770	7.822e-06	48.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HFD1_k127_2742679_2	234267.Acid_2283	5.978e-99	342.0	COG0526@1|root,COG0526@2|Bacteria,3Y4MM@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_2742679_6	1121920.AUAU01000015_gene1129	2.206e-54	198.0	COG3647@1|root,COG3647@2|Bacteria,3Y8PM@57723|Acidobacteria	57723|Acidobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2238
HFD1_k127_2742679_5	234267.Acid_4815	3.855e-57	201.0	COG3682@1|root,COG3682@2|Bacteria,3Y8BB@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_2742679_7	234267.Acid_4816	2.093e-39	162.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y8M9@57723|Acidobacteria	57723|Acidobacteria	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HFD1_k127_2742679_1	234267.Acid_4816	1.55e-147	488.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y8M9@57723|Acidobacteria	57723|Acidobacteria	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HFD1_k127_2742679_3	234267.Acid_4708	1.611e-78	267.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	-	-	2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1080,PEP-utilizers,PPDK_N
HFD1_k127_2742679_8	234267.Acid_2477	7.237e-36	141.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.17,3.5.1.28	ko:K01185,ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
HFD1_k127_2742679_0	234267.Acid_1003	4.929e-302	930.0	COG2407@1|root,COG2407@2|Bacteria,3Y63P@57723|Acidobacteria	57723|Acidobacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2742679_4	234267.Acid_0999	6.808e-60	210.0	COG4639@1|root,COG4639@2|Bacteria,3Y3YS@57723|Acidobacteria	57723|Acidobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HFD1_k127_2745672_7	234267.Acid_3661	7.867e-52	189.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_2745672_4	1267535.KB906767_gene2927	2.377e-108	364.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD1_k127_2745672_2	1267535.KB906767_gene2359	5.663e-117	384.0	COG3391@1|root,COG3391@2|Bacteria,3Y2SU@57723|Acidobacteria,2JKB8@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1
HFD1_k127_2745672_5	234267.Acid_6592	6.813e-105	350.0	COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria	2|Bacteria	G	Belongs to the GHMP kinase family. GalK subfamily	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HFD1_k127_2745672_0	234267.Acid_6591	0.0	1030.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD1_k127_2745672_6	1267535.KB906767_gene1314	2.492e-98	327.0	COG3605@1|root,COG3707@1|root,COG3605@2|Bacteria,COG3707@2|Bacteria,3Y72Q@57723|Acidobacteria,2JP7X@204432|Acidobacteriia	2|Bacteria	T	GAF domain	nasR	-	4.6.1.1	ko:K01768,ko:K02584,ko:K07183,ko:K22010	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00839	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022,ko03000	-	-	-	ANTAR,GAF_2,Response_reg
HFD1_k127_2745672_3	1429046.RR21198_4059	3.344e-112	389.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FX1G@85025|Nocardiaceae	201174|Actinobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HFD1_k127_2745672_12	234267.Acid_4740	8.478e-23	102.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_4740|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2745672_8	234267.Acid_1707	7.576e-50	189.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1707|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2745672_10	435591.BDI_3207	4.827e-47	183.0	COG0535@1|root,COG0535@2|Bacteria,4PA9R@976|Bacteroidetes,2FWDR@200643|Bacteroidia	976|Bacteroidetes	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HFD1_k127_2745672_9	234267.Acid_6300	1.712e-47	179.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,TehB
HFD1_k127_2745672_13	460265.Mnod_5890	3.637e-19	102.0	COG1216@1|root,COG1216@2|Bacteria,1RJPX@1224|Proteobacteria,2UFTW@28211|Alphaproteobacteria,1JRXX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_2745672_1	234267.Acid_6674	1.177e-177	561.0	COG0535@1|root,COG0535@2|Bacteria,3Y5QY@57723|Acidobacteria	57723|Acidobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HFD1_k127_2745672_11	661478.OP10G_4294	2.789e-43	165.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HFD1_k127_2750079_4	338969.Rfer_1825	3.552e-31	140.0	COG0784@1|root,COG2203@1|root,COG5001@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AH82@80864|Comamonadaceae	28216|Betaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,Response_reg
HFD1_k127_2750079_1	234267.Acid_5908	2.919e-107	367.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CHASE,DUF3365,GAF_2,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_2750079_0	234267.Acid_3373	1.109e-236	743.0	COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria	57723|Acidobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HFD1_k127_2750079_3	234267.Acid_3374	2.689e-40	151.0	COG3288@1|root,COG3288@2|Bacteria,3Y5PH@57723|Acidobacteria	57723|Acidobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HFD1_k127_2750079_2	234267.Acid_3375	8.262e-53	187.0	COG3288@1|root,COG3288@2|Bacteria,3Y2S0@57723|Acidobacteria	57723|Acidobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD1_k127_2758575_6	1183438.GKIL_4354	2.739e-78	278.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2758575_1	234267.Acid_4555	1.384e-269	839.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_4555|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2758575_12	1121377.KB906409_gene813	7.455e-05	55.0	2C7PP@1|root,2Z851@2|Bacteria	2|Bacteria	S	alginic acid biosynthetic process	algJ	-	-	ko:K19295	-	-	-	-	ko00000	-	-	-	ALGX
HFD1_k127_2758575_7	234267.Acid_7915	1.128e-56	205.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_2758575_8	106370.Francci3_2176	4.089e-41	164.0	2E3IT@1|root,32YH8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2758575_0	234267.Acid_7916	8.343e-302	948.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_2758575_2	234267.Acid_5614	3.515e-169	550.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3X0@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_2758575_9	419947.MRA_1850	7.071e-15	76.0	2BE1Z@1|root,327SM@2|Bacteria,2HDGJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2758575_11	234267.Acid_2463	3.346e-07	62.0	COG2133@1|root,COG2133@2|Bacteria,3Y81J@57723|Acidobacteria	57723|Acidobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_2758575_3	1267535.KB906767_gene4240	5.976e-130	437.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HFD1_k127_2758575_5	1304878.AUGD01000004_gene5327	1.778e-105	361.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,3JRE9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD1_k127_2758575_10	314278.NB231_04580	1.58e-09	66.0	COG1961@1|root,COG1961@2|Bacteria,1QJVX@1224|Proteobacteria,1SCGY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD1_k127_277026_0	234267.Acid_7324	7.23e-165	522.0	COG0028@1|root,COG0028@2|Bacteria,3Y3QI@57723|Acidobacteria	57723|Acidobacteria	EH	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_277026_1	234267.Acid_3882	3.34e-110	363.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_2773553_7	234267.Acid_0049	5.492e-06	49.0	2C8FF@1|root,333TN@2|Bacteria,3Y5GA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2773553_3	234267.Acid_0050	7.627e-99	340.0	2DRPK@1|root,32URD@2|Bacteria,3Y4UQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2773553_6	926550.CLDAP_34040	7.898e-07	56.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HFD1_k127_2773553_8	102125.Xen7305DRAFT_00044560	7.244e-05	48.0	2EMVS@1|root,33FI0@2|Bacteria,1GEE6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2773553_5	1123278.KB893567_gene2056	2.911e-07	56.0	COG2337@1|root,COG2337@2|Bacteria,4NYBW@976|Bacteroidetes,47SVE@768503|Cytophagia	976|Bacteroidetes	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD1_k127_2773553_1	234267.Acid_4681	2.406e-188	615.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_2773553_0	234267.Acid_4682	6.027e-269	841.0	COG5267@1|root,COG5267@2|Bacteria,3Y342@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD1_k127_2773553_4	234267.Acid_0607	5.342e-11	68.0	COG3824@1|root,COG3824@2|Bacteria,3Y8W9@57723|Acidobacteria	57723|Acidobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HFD1_k127_2773553_2	234267.Acid_7571	2.9e-158	506.0	COG0823@1|root,COG0823@2|Bacteria,3Y95P@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_2785404_1	234267.Acid_1287	2.622e-116	378.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_2785404_2	234267.Acid_1286	4.801e-65	222.0	COG3536@1|root,COG3536@2|Bacteria,3Y4UI@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HFD1_k127_2785404_0	234267.Acid_1285	7.644e-256	792.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria	57723|Acidobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD1_k127_2786586_2	234267.Acid_2180	7.102e-17	80.0	COG0500@1|root,COG2226@2|Bacteria,3Y7D3@57723|Acidobacteria	57723|Acidobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_2786586_0	1267535.KB906767_gene1411	3.06e-167	539.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD1_k127_2786586_3	886293.Sinac_2505	1.419e-10	72.0	2ESSA@1|root,33KAQ@2|Bacteria,2J1KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2786586_1	234267.Acid_2284	2.059e-123	406.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_2284|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2789837_1	234267.Acid_3900	7.89e-91	299.0	COG0740@1|root,COG0740@2|Bacteria,3Y2SY@57723|Acidobacteria	57723|Acidobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD1_k127_2789837_2	234267.Acid_3899	1.31e-88	293.0	COG1959@1|root,COG1959@2|Bacteria,3Y8ZE@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD1_k127_2789837_0	221288.JH992901_gene3895	5.583e-149	481.0	COG0715@1|root,COG0715@2|Bacteria,1GFIM@1117|Cyanobacteria	1117|Cyanobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
HFD1_k127_2789837_3	234267.Acid_6084	7.239e-30	124.0	COG3609@1|root,COG3609@2|Bacteria,3Y9AZ@57723|Acidobacteria	57723|Acidobacteria	K	addiction module antidote protein, CC2985 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2796372_3	234267.Acid_1603	2.144e-104	347.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_2796372_1	234267.Acid_1604	1.314e-161	525.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HATPase_c,HisKA_3
HFD1_k127_2796372_0	234267.Acid_6196	0.0	1259.0	COG1629@1|root,COG4774@1|root,COG4771@2|Bacteria,COG4774@2|Bacteria,3Y3WR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_2796372_4	234267.Acid_0033	3.728e-76	266.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_2796372_2	1267535.KB906767_gene4759	4.713e-151	493.0	COG1629@1|root,COG1629@2|Bacteria,3Y2N1@57723|Acidobacteria,2JIIP@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_2803539_0	234267.Acid_7323	5.161e-237	751.0	COG5479@1|root,COG5492@1|root,COG5479@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K11045	-	-	-	-	ko00000,ko02042	-	-	-	Big_2,CAMP_factor,CHB_HEX_C_1,LGFP,SLH
HFD1_k127_2810636_1	661478.OP10G_1743	5.229e-208	664.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127,RicinB_lectin_2
HFD1_k127_2810636_6	234267.Acid_5765	2.006e-27	117.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
HFD1_k127_2810636_2	234267.Acid_2837	6.003e-146	470.0	COG0823@1|root,COG0823@2|Bacteria,3Y89F@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	PD40
HFD1_k127_2810636_3	234267.Acid_2835	4.552e-104	348.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2810636_0	234267.Acid_2834	4.861e-248	772.0	COG1236@1|root,COG1236@2|Bacteria,3Y6U0@57723|Acidobacteria	57723|Acidobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HFD1_k127_2810636_4	234267.Acid_2832	3.173e-45	165.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_2810636_8	234267.Acid_0919	1.588e-14	81.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K09690,ko:K16554,ko:K16692	ko02010,ko05111,map02010,map05111	M00250	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1.103,8.A.3.1	-	-	CbiA,DUF2325,GNVR,Wzz
HFD1_k127_2810636_7	234267.Acid_0513	3.17e-25	121.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD1_k127_2810636_5	234267.Acid_2869	2.556e-39	159.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD1_k127_2820603_6	926560.KE387023_gene3745	7.667e-45	169.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
HFD1_k127_2820603_2	518766.Rmar_1391	1.785e-65	234.0	COG0684@1|root,COG0684@2|Bacteria	2|Bacteria	H	ribonuclease inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD1_k127_2820603_5	234267.Acid_0954	5.122e-52	201.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD1_k127_2820603_0	278963.ATWD01000001_gene2919	2.659e-168	574.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_2820603_7	93220.LV28_10690	9.155e-37	149.0	arCOG09511@1|root,2Z9DH@2|Bacteria,1N34W@1224|Proteobacteria,2VXV6@28216|Betaproteobacteria,1KB9R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
HFD1_k127_2820603_9	1198114.AciX9_3662	2.021e-34	144.0	COG0265@1|root,COG0265@2|Bacteria,3Y99F@57723|Acidobacteria,2JJ0S@204432|Acidobacteriia	204432|Acidobacteriia	O	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HFD1_k127_2820603_1	379066.GAU_0070	1.633e-153	520.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUF3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_2820603_3	1340493.JNIF01000003_gene2146	2.512e-57	207.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_2820603_4	933262.AXAM01000034_gene1565	2.156e-52	210.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_8,zinc_ribbon_4
HFD1_k127_2820603_10	886293.Sinac_2465	8.735e-28	124.0	2EMTG@1|root,33FFU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HFD1_k127_2820603_11	51337.XP_004668187.1	1.291e-12	81.0	COG0666@1|root,KOG0504@2759|Eukaryota,39Q2T@33154|Opisthokonta,3CQYU@33208|Metazoa,3E747@33213|Bilateria,48SP2@7711|Chordata,49P6T@7742|Vertebrata,3JQES@40674|Mammalia,35RNJ@314146|Euarchontoglires,4Q7Q0@9989|Rodentia	33208|Metazoa	S	ankyrin repeat domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD1_k127_2820603_8	1232410.KI421421_gene3795	3.213e-36	157.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,42TI1@68525|delta/epsilon subdivisions,2WPS7@28221|Deltaproteobacteria,43V71@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_5
HFD1_k127_2837248_10	234267.Acid_2438	1.977e-50	180.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD1_k127_2837248_0	234267.Acid_6158	0.0	1800.0	COG1629@1|root,COG4771@2|Bacteria,3Y6HD@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_2837248_1	234267.Acid_5022	2.139e-297	932.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_2837248_8	234267.Acid_2609	1.787e-76	262.0	2A5Y1@1|root,30UQ2@2|Bacteria,3Y7MH@57723|Acidobacteria	57723|Acidobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
HFD1_k127_2837248_3	234267.Acid_3250	1.085e-203	640.0	COG0626@1|root,COG0626@2|Bacteria	2|Bacteria	E	cystathionine gamma-synthase activity	megL	-	2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8	ko:K01739,ko:K01740,ko:K01760,ko:K01761,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01287,R01288,R02408,R02508,R03217,R03260,R04770,R04859,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD1_k127_2837248_2	234267.Acid_3249	1.506e-248	772.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HFD1_k127_2837248_11	234267.Acid_2330	5.937e-49	176.0	COG3093@1|root,COG3093@2|Bacteria,3Y5MG@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD1_k127_2837248_9	204669.Acid345_4530	3.344e-71	269.0	COG4805@1|root,COG4805@2|Bacteria,3Y4PP@57723|Acidobacteria,2JKV8@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2837248_12	903818.KI912268_gene1906	3.204e-47	178.0	2D4UK@1|root,32THN@2|Bacteria,3Y59Q@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3142
HFD1_k127_2837248_4	1267535.KB906767_gene4768	4.765e-167	537.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2837248_5	497965.Cyan7822_3235	6.255e-157	512.0	COG0451@1|root,COG0451@2|Bacteria,1G0IT@1117|Cyanobacteria,3KJ7S@43988|Cyanothece	1117|Cyanobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD1_k127_2837248_6	1340493.JNIF01000004_gene222	3.064e-131	424.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	2|Bacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_2837248_7	234267.Acid_7648	5.532e-112	368.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
HFD1_k127_2849683_7	234267.Acid_7859	1.164e-06	51.0	COG1565@1|root,COG1565@2|Bacteria,3Y583@57723|Acidobacteria	57723|Acidobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD1_k127_2849683_5	234267.Acid_7860	7.158e-94	313.0	COG1595@1|root,COG1595@2|Bacteria,3Y4FY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_2849683_6	234267.Acid_7861	2.038e-82	290.0	COG5343@1|root,COG5343@2|Bacteria,3Y4J0@57723|Acidobacteria	57723|Acidobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD1_k127_2849683_1	234267.Acid_7862	6.503e-171	545.0	COG0475@1|root,COG0475@2|Bacteria,3Y5D3@57723|Acidobacteria	57723|Acidobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD1_k127_2849683_4	234267.Acid_7863	1.021e-123	400.0	COG0179@1|root,COG0179@2|Bacteria,3Y30T@57723|Acidobacteria	57723|Acidobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HFD1_k127_2849683_3	204669.Acid345_4167	1.76e-141	460.0	COG1520@1|root,COG1520@2|Bacteria,3Y2H2@57723|Acidobacteria,2JM3H@204432|Acidobacteriia	204432|Acidobacteriia	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_3
HFD1_k127_2849683_0	562970.Btus_2112	1.015e-263	833.0	COG3256@1|root,COG3256@2|Bacteria,1TSW2@1239|Firmicutes,4HCFR@91061|Bacilli,279NB@186823|Alicyclobacillaceae	91061|Bacilli	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HFD1_k127_2849683_2	404589.Anae109_2966	4.269e-151	488.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,2YVA7@29|Myxococcales	28221|Deltaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD1_k127_2856691_4	2074.JNYD01000008_gene1128	9.586e-14	71.0	COG4877@1|root,COG4877@2|Bacteria,2GQV1@201174|Actinobacteria,4E6UQ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2856691_2	234267.Acid_3961	2.23e-51	185.0	2D0AC@1|root,32T87@2|Bacteria,3Y56N@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2856691_0	234267.Acid_4272	6.686e-187	613.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_2856691_1	1267535.KB906767_gene335	9.571e-147	467.0	COG3508@1|root,COG3508@2|Bacteria,3Y38R@57723|Acidobacteria	57723|Acidobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HFD1_k127_2884889_13	234267.Acid_7320	1.517e-56	201.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD1_k127_2884889_10	234267.Acid_7319	5.29e-131	422.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD1_k127_2884889_14	234267.Acid_7318	1.581e-41	162.0	COG2919@1|root,COG2919@2|Bacteria,3Y4JZ@57723|Acidobacteria	57723|Acidobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
HFD1_k127_2884889_2	234267.Acid_7317	6.238e-259	814.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HFD1_k127_2884889_3	234267.Acid_7316	7.286e-240	764.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_2884889_6	234267.Acid_7315	5.122e-195	620.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria	57723|Acidobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_2884889_4	234267.Acid_7314	1.329e-213	666.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria	57723|Acidobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD1_k127_2884889_5	234267.Acid_7313	1.314e-207	670.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_2884889_11	1267535.KB906767_gene2562	1.508e-115	383.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD1_k127_2884889_15	1000565.METUNv1_00412	9.752e-35	137.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,2VVHG@28216|Betaproteobacteria	28216|Betaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD1_k127_2884889_9	234267.Acid_7311	6.882e-164	522.0	COG0707@1|root,COG0707@2|Bacteria,3Y48B@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD1_k127_2884889_0	234267.Acid_7310	5.705e-267	825.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_2884889_12	234267.Acid_7309	9.546e-103	340.0	COG1589@1|root,COG1589@2|Bacteria,3Y3BQ@57723|Acidobacteria	57723|Acidobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HFD1_k127_2884889_8	234267.Acid_7308	2.721e-181	574.0	COG0849@1|root,COG0849@2|Bacteria,3Y432@57723|Acidobacteria	57723|Acidobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HFD1_k127_2884889_7	234267.Acid_7307	1.049e-190	602.0	COG0206@1|root,COG0206@2|Bacteria,3Y2WG@57723|Acidobacteria	57723|Acidobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD1_k127_2884889_16	234267.Acid_7304	8.746e-32	127.0	COG1828@1|root,COG1828@2|Bacteria,3Y5NE@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HFD1_k127_2884889_1	234267.Acid_7303	1.172e-262	819.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HFD1_k127_2896252_1	1267535.KB906767_gene4699	3.637e-70	242.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_2896252_0	1267535.KB906767_gene4838	5.826e-229	726.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD1_k127_2903743_3	1267535.KB906767_gene1889	2.144e-158	504.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia	204432|Acidobacteriia	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HFD1_k127_2903743_0	234267.Acid_7205	0.0	1024.0	COG0751@1|root,COG0751@2|Bacteria,3Y3KN@57723|Acidobacteria	57723|Acidobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HFD1_k127_2903743_2	234267.Acid_7206	5.289e-174	550.0	COG0752@1|root,COG0752@2|Bacteria,3Y3QC@57723|Acidobacteria	57723|Acidobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HFD1_k127_2903743_4	234267.Acid_7207	3.645e-84	286.0	COG1381@1|root,COG1381@2|Bacteria,3Y4AX@57723|Acidobacteria	57723|Acidobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HFD1_k127_2903743_5	234267.Acid_7213	1.406e-61	218.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_7213|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2903743_1	234267.Acid_7213	3.959e-209	674.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_7213|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2903743_6	234267.Acid_7214	5.355e-51	183.0	COG1695@1|root,COG1695@2|Bacteria,3Y510@57723|Acidobacteria	2|Bacteria	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_2903743_7	234267.Acid_1553	7.133e-29	130.0	COG3386@1|root,COG3386@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	NHL
HFD1_k127_2903743_8	1111730.ATTM01000007_gene2438	3.411e-11	75.0	COG4935@1|root,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia,2NU0I@237|Flavobacterium	976|Bacteroidetes	O	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	CUB,MAM,P_proprotein,Reprolysin_4,fn3
HFD1_k127_2905809_1	1267534.KB906754_gene3411	1.699e-30	124.0	2ADQJ@1|root,313FX@2|Bacteria,3Y7U5@57723|Acidobacteria,2JN16@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2905809_2	234267.Acid_0533	4.719e-20	93.0	290CR@1|root,2ZN27@2|Bacteria,3Y8Z2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2905809_0	234267.Acid_0534	1.709e-105	355.0	COG3480@1|root,COG3509@1|root,COG3480@2|Bacteria,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	lon	-	-	ko:K03932,ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	CE1	-	Esterase_phd,Lon_C,PDZ_2
HFD1_k127_2921240_4	234267.Acid_3185	1.348e-08	57.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	afr	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_2921240_2	1267534.KB906755_gene4131	7.139e-24	106.0	COG3801@1|root,COG3801@2|Bacteria	2|Bacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD1_k127_2921240_3	391625.PPSIR1_11821	2.044e-10	66.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2YVCD@29|Myxococcales	28221|Deltaproteobacteria	U	MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HFD1_k127_2921240_0	234267.Acid_7820	9.345e-136	449.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_2921240_1	234267.Acid_7818	2.739e-98	326.0	COG1520@1|root,COG1520@2|Bacteria,3Y6S9@57723|Acidobacteria	57723|Acidobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2926424_1	661478.OP10G_1529	1.868e-110	375.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_2926424_0	1198452.Jab_2c09150	8.166e-156	518.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,2WCWE@28216|Betaproteobacteria,478B5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2926424_3	1380390.JIAT01000012_gene3005	6.978e-37	151.0	COG3394@1|root,COG3394@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HFD1_k127_2926424_2	1380394.JADL01000003_gene5156	2.746e-98	344.0	COG0438@1|root,COG0438@2|Bacteria,1RAGT@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2926424_4	1298865.H978DRAFT_2215	1.885e-09	68.0	2EXT0@1|root,33R29@2|Bacteria,1NTDZ@1224|Proteobacteria,1SJWT@1236|Gammaproteobacteria,46AAM@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HFD1_k127_2927606_1	234267.Acid_4821	4.246e-106	351.0	COG1612@1|root,COG1612@2|Bacteria,3Y3C7@57723|Acidobacteria	57723|Acidobacteria	O	cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HFD1_k127_2927606_2	234267.Acid_4820	1.098e-55	198.0	COG3682@1|root,COG3682@2|Bacteria,3Y8BB@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_2927606_0	234267.Acid_4819	1.65e-133	448.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y8M9@57723|Acidobacteria	57723|Acidobacteria	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_M56,TonB_C
HFD1_k127_2927606_3	234267.Acid_2824	1.901e-28	128.0	COG0473@1|root,COG0473@2|Bacteria,3Y3BC@57723|Acidobacteria	57723|Acidobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD1_k127_2929216_2	1068980.ARVW01000001_gene5018	1.935e-63	243.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4DZZ0@85010|Pseudonocardiales	201174|Actinobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD1_k127_2929216_0	234267.Acid_7060	5.967e-221	694.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_2929216_1	234267.Acid_7061	2.29e-206	647.0	COG0673@1|root,COG0673@2|Bacteria,3Y78W@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_2929216_3	234267.Acid_6504	2.71e-11	66.0	COG2982@1|root,COG2982@2|Bacteria,3Y2J8@57723|Acidobacteria	57723|Acidobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD1_k127_2937926_1	234267.Acid_0858	2.615e-131	426.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD1_k127_2937926_2	234267.Acid_0857	9.608e-126	411.0	COG3391@1|root,COG3391@2|Bacteria,3Y5TX@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_2937926_0	234267.Acid_0856	1.433e-155	500.0	COG3391@1|root,COG3391@2|Bacteria,3Y5TX@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_2937926_4	234267.Acid_0855	8.15e-27	118.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,Copper-bind,Cytochrom_C,Cytochrome_CBB3,DUF1573,Laminin_G_3,ThuA
HFD1_k127_2937926_3	234267.Acid_4800	9.553e-122	393.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
HFD1_k127_2955747_0	234267.Acid_1559	3.283e-187	589.0	COG0498@1|root,COG0498@2|Bacteria,3Y3G4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_2955747_1	234267.Acid_1558	2.249e-131	427.0	COG1063@1|root,COG1063@2|Bacteria,3Y7C5@57723|Acidobacteria	57723|Acidobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD1_k127_2955747_3	1340493.JNIF01000003_gene1393	2.092e-26	109.0	COG2261@1|root,COG2261@2|Bacteria,3Y5KH@57723|Acidobacteria	57723|Acidobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD1_k127_2955747_2	234267.Acid_4185	8.097e-59	208.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0030798,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942	Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD1_k127_2972312_3	234267.Acid_5099	3.071e-39	147.0	COG0200@1|root,COG0200@2|Bacteria,3Y4JC@57723|Acidobacteria	57723|Acidobacteria	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD1_k127_2972312_0	234267.Acid_5098	1.049e-263	816.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD1_k127_2972312_2	234267.Acid_5097	1.029e-99	329.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD1_k127_2972312_1	234267.Acid_5096	5.679e-152	481.0	COG0024@1|root,COG0024@2|Bacteria,3Y2HJ@57723|Acidobacteria	57723|Acidobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD1_k127_2972312_4	1382359.JIAL01000001_gene1718	8.85e-12	72.0	COG0361@1|root,COG0361@2|Bacteria,3Y55Z@57723|Acidobacteria,2JJUQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD1_k127_2972312_5	234267.Acid_5094	3.809e-09	62.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HFD1_k127_2980684_8	234267.Acid_0803	5.482e-13	72.0	2A0AW@1|root,30NEB@2|Bacteria,3Y96N@57723|Acidobacteria	57723|Acidobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HFD1_k127_2980684_1	234267.Acid_3589	5.666e-177	561.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD1_k127_2980684_3	234267.Acid_3588	1.942e-136	437.0	COG1611@1|root,COG1611@2|Bacteria,3Y2MR@57723|Acidobacteria	57723|Acidobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD1_k127_2980684_4	1254432.SCE1572_20370	1.517e-95	329.0	COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,42ZR1@68525|delta/epsilon subdivisions,2WV1F@28221|Deltaproteobacteria,2YZWT@29|Myxococcales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_2980684_5	234267.Acid_3587	1.76e-75	269.0	COG1670@1|root,COG1670@2|Bacteria,3Y8PA@57723|Acidobacteria	57723|Acidobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HFD1_k127_2980684_0	234267.Acid_4727	0.0	1290.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat
HFD1_k127_2980684_2	1038869.AXAN01000004_gene1180	5.183e-158	509.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2VNS4@28216|Betaproteobacteria,1K4VU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid peptide transporter	dtpA	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD1_k127_2980684_6	768671.ThimaDRAFT_1210	3.084e-67	246.0	2DKXC@1|root,30RJ8@2|Bacteria,1R3H2@1224|Proteobacteria,1T67X@1236|Gammaproteobacteria,1X2X3@135613|Chromatiales	135613|Chromatiales	S	Paraquat-inducible protein A	-	-	-	-	-	-	-	-	-	-	-	-	PqiA
HFD1_k127_2980684_7	682795.AciX8_4812	5.127e-66	243.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria,3Y83C@57723|Acidobacteria	57723|Acidobacteria	I	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD1_k127_3005330_6	861299.J421_2101	4.121e-15	82.0	COG0739@1|root,COG0739@2|Bacteria,1ZTXC@142182|Gemmatimonadetes	2|Bacteria	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD1_k127_3005330_1	234267.Acid_2136	6.432e-131	425.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	Muraidase,PG_binding_1,YkuD
HFD1_k127_3005330_3	234267.Acid_2154	9.477e-108	360.0	COG1409@1|root,COG1409@2|Bacteria,3Y91N@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_3005330_4	234267.Acid_2155	3.332e-82	275.0	2E65M@1|root,330UB@2|Bacteria	2|Bacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_3005330_2	234267.Acid_2156	1.961e-118	392.0	COG0623@1|root,COG0623@2|Bacteria	2|Bacteria	I	enoyl-[acyl-carrier-protein] reductase (NADH) activity	-	-	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_3005330_5	234267.Acid_2157	1.322e-57	203.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD1_k127_3005330_0	234267.Acid_2158	3.247e-176	561.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD1_k127_3016617_0	234267.Acid_1796	5.679e-292	903.0	COG1501@1|root,COG1501@2|Bacteria,3Y4C8@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Glyco_hydro_31
HFD1_k127_3016617_1	234267.Acid_3537	3.654e-210	674.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD1_k127_3016617_2	234267.Acid_3043	1.907e-07	63.0	COG3055@1|root,COG3055@2|Bacteria,3Y6HA@57723|Acidobacteria	2|Bacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060,Kelch_1,Kelch_6,Malectin,NPCBM
HFD1_k127_3051276_1	234267.Acid_3799	1.529e-114	382.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
HFD1_k127_3051276_0	234267.Acid_5413	2.804e-230	727.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6AS@57723|Acidobacteria	57723|Acidobacteria	CG	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_3067295_4	234267.Acid_0729	2.216e-108	359.0	COG1538@1|root,COG1538@2|Bacteria,3Y6AC@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_3067295_1	234267.Acid_5780	0.0	1331.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
HFD1_k127_3067295_3	234267.Acid_5781	1.213e-245	767.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_3067295_0	234267.Acid_5782	0.0	1387.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3067295_2	234267.Acid_7177	0.0	1019.0	COG0577@1|root,COG0577@2|Bacteria,3Y402@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3067295_5	204669.Acid345_2354	3.4e-55	197.0	COG2318@1|root,COG2318@2|Bacteria,3Y52D@57723|Acidobacteria,2JJJT@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_3067295_6	452471.Aasi_0623	0.0006651	42.0	29KMP@1|root,2Z9ZF@2|Bacteria,4NKVK@976|Bacteroidetes,47QGW@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HFD1_k127_3067751_3	234267.Acid_4371	3.106e-24	103.0	COG0828@1|root,COG0828@2|Bacteria,3Y5J9@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD1_k127_3067751_4	1408422.JHYF01000011_gene3399	2.054e-17	85.0	COG3478@1|root,COG3478@2|Bacteria,1VKSK@1239|Firmicutes,24WD3@186801|Clostridia	186801|Clostridia	S	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3067751_0	234267.Acid_4491	0.0	1645.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD1_k127_3067751_1	234267.Acid_6092	2.545e-86	290.0	COG1574@1|root,COG1574@2|Bacteria,3Y7EK@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD1_k127_3074899_0	234267.Acid_2120	2.668e-245	786.0	COG1361@1|root,COG1361@2|Bacteria,3Y2G0@57723|Acidobacteria	57723|Acidobacteria	M	Alpha-L-arabinofuranosidase B, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	ArabFuran-catal,LTD,NPCBM_assoc
HFD1_k127_3092256_1	234267.Acid_5065	2.614e-237	747.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria	57723|Acidobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD1_k127_3092256_10	234267.Acid_5064	1.996e-07	53.0	COG1968@1|root,COG1968@2|Bacteria,3Y588@57723|Acidobacteria	57723|Acidobacteria	V	Bacitracin resistance protein BacA	-	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD1_k127_3092256_7	234267.Acid_4822	7.987e-42	163.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	ltg	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD1_k127_3092256_3	234267.Acid_4823	1.331e-167	534.0	COG2081@1|root,COG2081@2|Bacteria,3Y3KG@57723|Acidobacteria	57723|Acidobacteria	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HFD1_k127_3092256_6	234267.Acid_4824	1.184e-87	292.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD1_k127_3092256_4	234267.Acid_4834	3.755e-164	527.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria	57723|Acidobacteria	M	PFAM penicillin-binding protein transpeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HFD1_k127_3092256_5	234267.Acid_4835	2.641e-105	347.0	COG1573@1|root,COG1573@2|Bacteria,3Y4AT@57723|Acidobacteria	57723|Acidobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD1_k127_3092256_2	234267.Acid_4618	3.064e-211	665.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria	57723|Acidobacteria	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HFD1_k127_3092256_0	234267.Acid_2823	0.0	1109.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD1_k127_3092256_8	1340493.JNIF01000003_gene2735	2.381e-31	139.0	COG2304@1|root,COG2304@2|Bacteria,3Y8A4@57723|Acidobacteria	57723|Acidobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HFD1_k127_3092256_9	179408.Osc7112_4515	1.054e-07	55.0	COG2913@1|root,COG2913@2|Bacteria,1G7DP@1117|Cyanobacteria,1HBT7@1150|Oscillatoriales	1117|Cyanobacteria	J	Protein of unknown function (DUF3574)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3574
HFD1_k127_3113736_1	1340493.JNIF01000003_gene4042	6.33e-217	688.0	COG1629@1|root,COG1629@2|Bacteria,3Y765@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3113736_2	1096546.WYO_2037	3.093e-29	122.0	COG1487@1|root,COG1487@2|Bacteria,1MZZ9@1224|Proteobacteria,2UDJY@28211|Alphaproteobacteria,1JY7N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_3113736_3	1028800.RG540_CH09190	4.554e-14	74.0	COG5450@1|root,COG5450@2|Bacteria,1N75T@1224|Proteobacteria,2UFNE@28211|Alphaproteobacteria,4BH4N@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HFD1_k127_3113736_0	1379698.RBG1_1C00001G0777	2.299e-308	959.0	COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HFD1_k127_3138336_1	756067.MicvaDRAFT_2413	4.249e-185	585.0	COG1063@1|root,COG1063@2|Bacteria,1G26C@1117|Cyanobacteria,1H92J@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Alcohol dehydrogenase GroES-like	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HFD1_k127_3138336_7	1173024.KI912151_gene2147	1.54e-16	89.0	COG0300@1|root,COG0300@2|Bacteria,1G1AT@1117|Cyanobacteria,1JKU3@1189|Stigonemataceae	1117|Cyanobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3138336_4	234267.Acid_2997	2.671e-76	261.0	COG0300@1|root,COG0300@2|Bacteria,3Y3YQ@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3138336_8	204669.Acid345_3915	4.737e-15	76.0	2E4YG@1|root,3020Q@2|Bacteria,3Y5VS@57723|Acidobacteria,2JK3P@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD1_k127_3138336_2	234267.Acid_7178	1.556e-161	522.0	COG0728@1|root,COG0728@2|Bacteria	2|Bacteria	M	peptidoglycan biosynthetic process	pslK	-	-	ko:K21004	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	MVIN
HFD1_k127_3138336_3	234267.Acid_7179	2.277e-93	308.0	COG2077@1|root,COG2077@2|Bacteria,3Y5DK@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
HFD1_k127_3138336_0	234267.Acid_7180	1.367e-313	973.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HFD1_k127_3138336_5	97138.C820_00130	5.673e-51	194.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,249ZX@186801|Clostridia,36GI0@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA_1	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS,DUF1357_C,DUF1537
HFD1_k127_3138336_9	1267535.KB906767_gene1390	1.699e-11	73.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3140190_1	264732.Moth_0912	4.18e-07	53.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HFD1_k127_3140190_0	234267.Acid_5940	4.896e-158	529.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_3165923_4	452637.Oter_2464	2.402e-14	72.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,46TQW@74201|Verrucomicrobia,3K7GA@414999|Opitutae	74201|Verrucomicrobia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
HFD1_k127_3165923_1	452637.Oter_2465	8.557e-104	344.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,46VST@74201|Verrucomicrobia,3K7DE@414999|Opitutae	74201|Verrucomicrobia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HFD1_k127_3165923_3	234267.Acid_7227	4.134e-37	156.0	COG0640@1|root,COG0640@2|Bacteria,3Y5UV@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_3165923_0	1382359.JIAL01000001_gene1072	1.546e-235	748.0	COG0659@1|root,COG0659@2|Bacteria,3Y3QP@57723|Acidobacteria,2JJPK@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HFD1_k127_3165923_2	886293.Sinac_3694	1.119e-61	219.0	COG3568@1|root,COG3568@2|Bacteria,2IZ9W@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD1_k127_3178993_0	1005048.CFU_3175	8.862e-114	393.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2VJSU@28216|Betaproteobacteria,472GB@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	TonB dependent receptor	tonR2	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD1_k127_3179879_2	234267.Acid_7508	2.595e-66	229.0	COG4409@1|root,COG4409@2|Bacteria,3Y692@57723|Acidobacteria	57723|Acidobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3179879_0	661478.OP10G_3101	4.269e-136	442.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HFD1_k127_3179879_1	1340493.JNIF01000003_gene2517	3.067e-72	251.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3180911_8	221288.JH992901_gene1687	4.909e-38	144.0	COG1695@1|root,COG1695@2|Bacteria,1GDRG@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_3180911_3	1267535.KB906767_gene2010	4.967e-126	422.0	COG1538@1|root,COG1538@2|Bacteria,3Y3KB@57723|Acidobacteria,2JK7S@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_3180911_0	401053.AciPR4_2695	0.0	1343.0	COG0841@1|root,COG0841@2|Bacteria,3Y309@57723|Acidobacteria,2JKM2@204432|Acidobacteriia	204432|Acidobacteriia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_3180911_4	1267535.KB906767_gene2008	3.171e-102	343.0	COG0845@1|root,COG0845@2|Bacteria,3Y2U2@57723|Acidobacteria,2JMFW@204432|Acidobacteriia	204432|Acidobacteriia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_3180911_2	234267.Acid_2199	3.306e-138	450.0	COG0477@1|root,COG2814@2|Bacteria,3Y2VT@57723|Acidobacteria	57723|Acidobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_3180911_7	234267.Acid_4013	3.651e-42	174.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3180911_1	234267.Acid_3381	0.0	1204.0	COG3533@1|root,COG3533@2|Bacteria,3Y7GP@57723|Acidobacteria	57723|Acidobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD1_k127_3180911_5	278963.ATWD01000002_gene689	5.181e-87	313.0	COG3240@1|root,COG3240@2|Bacteria,3Y779@57723|Acidobacteria,2JM72@204432|Acidobacteriia	204432|Acidobacteriia	I	lipase activity	-	-	-	ko:K21831	-	-	-	-	ko00000	-	-	-	-
HFD1_k127_3180911_6	1123276.KB893246_gene700	2.785e-64	245.0	COG0657@1|root,COG0657@2|Bacteria,4PKKH@976|Bacteroidetes,47KC9@768503|Cytophagia	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Abhydrolase_3,DLH
HFD1_k127_3180911_9	234267.Acid_5479	3.112e-27	113.0	COG2442@1|root,COG2442@2|Bacteria,3Y8U9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD1_k127_3180911_10	497965.Cyan7822_1092	2.68e-17	85.0	COG4634@1|root,COG4634@2|Bacteria,1G71Y@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3184730_0	234267.Acid_4151	0.0	1433.0	COG0841@1|root,COG0841@2|Bacteria,3Y2SK@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_3184730_3	234267.Acid_4152	1.06e-127	420.0	COG0845@1|root,COG0845@2|Bacteria,3Y4YK@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_3184730_1	234267.Acid_4153	2.354e-171	548.0	COG1538@1|root,COG1538@2|Bacteria,3Y5F3@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_3184730_2	667014.Thein_0169	2.881e-130	434.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GHCT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
HFD1_k127_3188927_10	1121373.KB903642_gene3693	1.088e-15	91.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Fasciclin
HFD1_k127_3188927_13	1267535.KB906767_gene3471	1.01e-05	58.0	COG0810@1|root,COG0810@2|Bacteria,3Y8HF@57723|Acidobacteria	57723|Acidobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3188927_11	649638.Trad_0216	4.039e-13	78.0	COG2197@1|root,COG2197@2|Bacteria,1WJUW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD1_k127_3188927_1	234267.Acid_4290	9.883e-238	747.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
HFD1_k127_3188927_7	234267.Acid_5576	4.85e-81	287.0	COG4783@1|root,COG4783@2|Bacteria,3Y7P0@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_3188927_12	1202962.KB907159_gene3258	1.928e-12	79.0	COG4775@1|root,COG4775@2|Bacteria,1RDM0@1224|Proteobacteria,1SK9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HFD1_k127_3188927_5	309807.SRU_0977	1.232e-85	304.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3188927_2	1340493.JNIF01000004_gene791	1.684e-173	562.0	COG0515@1|root,COG0515@2|Bacteria	1340493.JNIF01000004_gene791|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3188927_3	448385.sce6976	3.278e-97	344.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
HFD1_k127_3188927_8	693986.MOC_0603	5.62e-28	130.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HFD1_k127_3188927_6	234267.Acid_1776	2.266e-81	306.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_3188927_4	234267.Acid_4419	2.385e-92	318.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3188927_0	234267.Acid_2982	3.782e-294	940.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_2982|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3203213_6	861299.J421_1872	5.352e-117	379.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HFD1_k127_3203213_18	861299.J421_1872	2.098e-30	131.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HFD1_k127_3203213_13	251221.35211726	9.517e-73	258.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD1_k127_3203213_21	382464.ABSI01000005_gene1399	2.639e-20	99.0	COG2318@1|root,COG2318@2|Bacteria,46WF2@74201|Verrucomicrobia,2IWE9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3203213_16	203122.Sde_1195	2.279e-39	164.0	COG3332@1|root,COG3332@2|Bacteria,1RE1W@1224|Proteobacteria,1S59Q@1236|Gammaproteobacteria,469A0@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HFD1_k127_3203213_7	382464.ABSI01000005_gene1401	4.069e-102	352.0	COG0189@1|root,COG0586@1|root,COG0189@2|Bacteria,COG0586@2|Bacteria,46UXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	HJ	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD1_k127_3203213_23	7222.FBpp0158735	1.665e-06	54.0	KOG1230@1|root,KOG1230@2759|Eukaryota,38CJ4@33154|Opisthokonta,3BBC2@33208|Metazoa,3CZT2@33213|Bilateria,41VPY@6656|Arthropoda,3SH8Y@50557|Insecta,44WUF@7147|Diptera,45V7R@7214|Drosophilidae	33208|Metazoa	S	Kelch motif	KLHDC4	-	-	-	-	-	-	-	-	-	-	-	Kelch_2,Kelch_3,Kelch_4,Kelch_5
HFD1_k127_3203213_17	700598.Niako_3839	2.747e-31	128.0	2C87P@1|root,32H7J@2|Bacteria,4NS7S@976|Bacteroidetes,1IYAE@117747|Sphingobacteriia	976|Bacteroidetes	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
HFD1_k127_3203213_2	156889.Mmc1_2481	1.033e-144	478.0	COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TWW3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
HFD1_k127_3203213_19	489825.LYNGBM3L_01300	2.036e-29	126.0	29EN4@1|root,301K2@2|Bacteria,1G4I6@1117|Cyanobacteria,1HET5@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3203213_3	1185876.BN8_02790	2.153e-124	409.0	COG2146@1|root,COG2717@1|root,COG2146@2|Bacteria,COG2717@2|Bacteria,4NJUW@976|Bacteroidetes,47TAG@768503|Cytophagia	976|Bacteroidetes	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct,Rieske
HFD1_k127_3203213_11	234267.Acid_3654	1.813e-77	273.0	COG1028@1|root,COG1028@2|Bacteria,3Y822@57723|Acidobacteria	57723|Acidobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3203213_4	1267535.KB906767_gene1361	4.532e-123	400.0	COG1028@1|root,COG1028@2|Bacteria,3Y2JR@57723|Acidobacteria,2JJ3M@204432|Acidobacteriia	1267535.KB906767_gene1361|-	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3203213_14	111781.Lepto7376_1849	2.243e-43	175.0	COG3350@1|root,COG3350@2|Bacteria,1G6RV@1117|Cyanobacteria,1HBTF@1150|Oscillatoriales	1117|Cyanobacteria	S	Yhs domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HFD1_k127_3203213_10	234267.Acid_3141	6.289e-79	267.0	COG1595@1|root,COG1595@2|Bacteria,3Y5J6@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_3203213_9	234267.Acid_3140	1.345e-84	293.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD1_k127_3203213_12	927677.ALVU02000001_gene2235	2.314e-74	263.0	COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Bacterial low temperature requirement A protein (LtrA)	-	-	-	-	-	-	-	-	-	-	-	-	LtrA
HFD1_k127_3203213_1	234267.Acid_3143	5.056e-227	719.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD1_k127_3203213_0	671143.DAMO_0621	0.0	1369.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HFD1_k127_3203213_15	1267535.KB906767_gene3098	7.577e-43	166.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria,2JJBS@204432|Acidobacteriia	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD1_k127_3203213_8	927658.AJUM01000043_gene729	3.418e-91	311.0	COG1506@1|root,COG1506@2|Bacteria,4PN2U@976|Bacteroidetes	976|Bacteroidetes	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3203213_5	1446473.JHWH01000014_gene2572	3.387e-120	390.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2PUHY@265|Paracoccus	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD2	-	4.2.1.25,4.2.1.82	ko:K13875,ko:K22186	ko00040,ko00053,ko01100,map00040,map00053,map01100	-	R02429,R02522	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
HFD1_k127_3220539_6	1267533.KB906738_gene2200	3.932e-56	206.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	yhcS	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD1_k127_3220539_1	1267534.KB906758_gene2333	1.425e-94	320.0	COG4313@1|root,COG4313@2|Bacteria,3Y6XM@57723|Acidobacteria,2JKRN@204432|Acidobacteriia	204432|Acidobacteriia	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3220539_5	234267.Acid_2881	5.149e-60	215.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_3220539_2	234267.Acid_1521	3.745e-93	323.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3220539_3	1340493.JNIF01000003_gene2460	2.292e-87	299.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD1_k127_3220539_4	234267.Acid_3382	1.611e-64	228.0	COG2885@1|root,COG2885@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3220539_0	234267.Acid_2882	1.567e-177	568.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_3220539_7	215803.DB30_3254	1.913e-34	137.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,438S3@68525|delta/epsilon subdivisions,2X3YW@28221|Deltaproteobacteria,2YXN3@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HFD1_k127_3226952_1	234267.Acid_4361	1.625e-166	526.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	57723|Acidobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HFD1_k127_3226952_3	234267.Acid_4362	1.634e-69	244.0	COG0457@1|root,COG0457@2|Bacteria,3Y4XQ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_3226952_2	234267.Acid_4363	1.047e-149	482.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria	57723|Acidobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HFD1_k127_3226952_0	234267.Acid_4364	6.984e-207	651.0	COG1207@1|root,COG1207@2|Bacteria,3Y3SI@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HFD1_k127_3253874_1	861299.J421_3249	1.563e-78	288.0	COG0463@1|root,COG0463@2|Bacteria,1ZTEI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_3253874_0	861299.J421_3250	3.528e-191	606.0	COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-54 factor, Activator interacting domain (AID)	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD1_k127_3256892_8	234267.Acid_2583	6.176e-52	188.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_3256892_4	234267.Acid_3330	2.461e-88	303.0	COG2948@1|root,COG2948@2|Bacteria	2|Bacteria	U	multi-organism process	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
HFD1_k127_3256892_2	1340493.JNIF01000003_gene2431	4.892e-167	539.0	COG1524@1|root,COG1524@2|Bacteria,3Y4MJ@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_3256892_10	234267.Acid_7216	1.03e-26	113.0	COG3115@1|root,COG3115@2|Bacteria	2|Bacteria	D	cell septum assembly	-	-	-	ko:K02487,ko:K06596,ko:K08372	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko02022,ko02035	-	-	-	FliO,SPOR,ZipA_C
HFD1_k127_3256892_11	404380.Gbem_2947	2.252e-26	117.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,Response_reg
HFD1_k127_3256892_9	234267.Acid_7217	5.745e-31	126.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3256892_5	234267.Acid_7218	1.879e-77	261.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_3256892_0	234267.Acid_7219	0.0	1009.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD1_k127_3256892_6	234267.Acid_6678	1.897e-72	255.0	COG2823@1|root,COG2823@2|Bacteria,3Y7ZV@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3256892_1	234267.Acid_6679	6.571e-185	581.0	COG0042@1|root,COG0042@2|Bacteria,3Y3XE@57723|Acidobacteria	57723|Acidobacteria	J	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HFD1_k127_3256892_7	234267.Acid_6680	2.906e-71	270.0	COG0328@1|root,COG0328@2|Bacteria,3Y5EM@57723|Acidobacteria	57723|Acidobacteria	L	RNase H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HFD1_k127_3256892_3	234267.Acid_1996	1.54e-92	307.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria	57723|Acidobacteria	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HFD1_k127_3260262_2	1242864.D187_006882	3.126e-120	416.0	COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria	1224|Proteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_3260262_0	234267.Acid_4475	0.0	1372.0	COG1629@1|root,COG4771@2|Bacteria,3Y3SU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TonB_dep_Rec
HFD1_k127_3260262_1	1340493.JNIF01000003_gene3565	2.088e-297	935.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3260736_0	1444712.BN1013_00117	1.324e-95	349.0	COG3391@1|root,COG4625@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,2JGK7@204428|Chlamydiae	204428|Chlamydiae	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
HFD1_k127_3260736_1	234267.Acid_7902	1.926e-56	207.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,Reg_prop,TPR_12,Y_Y_Y
HFD1_k127_3260736_8	1123389.ATXJ01000005_gene1913	4.456e-05	48.0	2DDVS@1|root,2ZJH8@2|Bacteria,1WKKW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3260736_3	1122939.ATUD01000011_gene2221	4.837e-17	83.0	COG4118@1|root,COG4118@2|Bacteria,2HRVX@201174|Actinobacteria,4CTZD@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD1_k127_3260736_2	604331.AUHY01000040_gene94	1.359e-32	132.0	COG3744@1|root,COG3744@2|Bacteria,1WKBP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_3260736_5	629265.PMA4326_23991	3.413e-10	61.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria,1Z7SV@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	L	Tn3 transposase DDE domain	tnpA	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HFD1_k127_3260736_6	519989.ECTPHS_10164	6.251e-10	62.0	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,1SDTJ@1236|Gammaproteobacteria,1WZ8Q@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD1_k127_3260736_7	1155714.KB891998_gene1060	8.204e-09	57.0	COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HFD1_k127_3261297_3	1340493.JNIF01000003_gene3295	2.331e-129	424.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD1_k127_3261297_0	234267.Acid_4160	1.071e-229	732.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD1_k127_3261297_6	234267.Acid_4159	2.914e-114	395.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_3261297_5	234267.Acid_4158	4.397e-116	380.0	COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_3261297_7	234267.Acid_1717	4.401e-92	309.0	COG0688@1|root,COG0688@2|Bacteria,3Y4AZ@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD1_k127_3261297_4	234267.Acid_1718	3.951e-129	418.0	COG1183@1|root,COG1183@2|Bacteria,3Y3I7@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HFD1_k127_3261297_2	234267.Acid_1719	2.551e-144	465.0	COG0136@1|root,COG0136@2|Bacteria,3Y395@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD1_k127_3261297_10	234267.Acid_1720	2.423e-54	202.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria	57723|Acidobacteria	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
HFD1_k127_3261297_1	234267.Acid_1721	3.012e-146	486.0	COG1466@1|root,COG1466@2|Bacteria,3Y2XE@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HFD1_k127_3261297_15	234267.Acid_1721	5.945e-06	49.0	COG1466@1|root,COG1466@2|Bacteria,3Y2XE@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HFD1_k127_3261297_12	234267.Acid_1723	1.879e-37	142.0	COG0268@1|root,COG0268@2|Bacteria,3Y5CZ@57723|Acidobacteria	57723|Acidobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD1_k127_3261297_9	204669.Acid345_2055	4.051e-58	223.0	COG2982@1|root,COG2982@2|Bacteria,3Y2J8@57723|Acidobacteria,2JKPW@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD1_k127_3261297_11	234267.Acid_0537	9.606e-53	196.0	COG3695@1|root,COG3695@2|Bacteria,3Y85U@57723|Acidobacteria	57723|Acidobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
HFD1_k127_3261297_8	497964.CfE428DRAFT_2876	1.245e-87	293.0	COG2818@1|root,COG2818@2|Bacteria,46SS9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HFD1_k127_3261297_14	234267.Acid_0534	8.331e-16	78.0	COG3480@1|root,COG3509@1|root,COG3480@2|Bacteria,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	lon	-	-	ko:K03932,ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	CE1	-	Esterase_phd,Lon_C,PDZ_2
HFD1_k127_3261297_16	234267.Acid_0534	4.633e-05	46.0	COG3480@1|root,COG3509@1|root,COG3480@2|Bacteria,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	lon	-	-	ko:K03932,ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	CE1	-	Esterase_phd,Lon_C,PDZ_2
HFD1_k127_3272337_3	590998.Celf_1984	3.211e-45	175.0	COG3170@1|root,COG3170@2|Bacteria,2IANU@201174|Actinobacteria	201174|Actinobacteria	NU	Astacin (Peptidase family M12A)	-	-	-	-	-	-	-	-	-	-	-	-	Astacin
HFD1_k127_3272337_6	234267.Acid_3661	1.257e-12	71.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_3272337_2	234267.Acid_6834	1.021e-69	262.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_3272337_7	1429046.RR21198_0312	9.841e-06	58.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria	201174|Actinobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_3272337_4	1267534.KB906754_gene3445	1.529e-37	149.0	2E129@1|root,32WI1@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HFD1_k127_3272337_0	1267535.KB906767_gene2503	2.541e-162	516.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria,2JHZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD1_k127_3272337_5	686340.Metal_0729	5.811e-31	124.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,1SAWR@1236|Gammaproteobacteria,1XFGD@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD1_k127_3272337_1	234267.Acid_7852	7.075e-85	296.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_3272337_8	118161.KB235922_gene3425	3.55e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,1GE3W@1117|Cyanobacteria,3VMT0@52604|Pleurocapsales	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HFD1_k127_3278284_2	452637.Oter_0875	6.674e-134	433.0	COG0055@1|root,COG0055@2|Bacteria,46SCC@74201|Verrucomicrobia,3K7MW@414999|Opitutae	414999|Opitutae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD1_k127_3278284_5	497964.CfE428DRAFT_4490	1.403e-77	268.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HFD1_k127_3278284_1	497964.CfE428DRAFT_4491	1.745e-233	732.0	COG0056@1|root,COG0056@2|Bacteria,46SB5@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD1_k127_3278284_8	478741.JAFS01000002_gene619	6.74e-18	94.0	COG0712@1|root,COG0712@2|Bacteria,46TC4@74201|Verrucomicrobia,37GUB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	ATP synthase delta (OSCP) subunit	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD1_k127_3278284_6	497964.CfE428DRAFT_4493	2.612e-33	135.0	COG0711@1|root,COG0711@2|Bacteria,46SYI@74201|Verrucomicrobia	74201|Verrucomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD1_k127_3278284_9	497964.CfE428DRAFT_4494	2.901e-12	79.0	2DS8G@1|root,33EZT@2|Bacteria,46T9M@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD1_k127_3278284_4	497964.CfE428DRAFT_4495	1.665e-98	331.0	COG0356@1|root,COG0356@2|Bacteria,46SVZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD1_k127_3278284_7	1205680.CAKO01000015_gene129	4.237e-24	113.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,2U33B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HFD1_k127_3278284_3	204669.Acid345_4072	1.414e-114	391.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HFD1_k127_3278284_0	1396141.BATP01000039_gene1356	7.831e-274	863.0	COG0841@1|root,COG0841@2|Bacteria,46U0U@74201|Verrucomicrobia,2ITVP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_3283621_9	1185652.USDA257_c10760	5.9e-20	91.0	COG2605@1|root,COG2605@2|Bacteria,1PDHJ@1224|Proteobacteria,2U1G3@28211|Alphaproteobacteria,4BIX8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD1_k127_3283621_7	1120985.AUMI01000014_gene827	2.335e-50	190.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes	1239|Firmicutes	M	dTDP-4-dehydrorhamnose 3,5-epimerase	spsL	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD1_k127_3283621_2	1185652.USDA257_c10770	1.153e-127	424.0	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,4BDWC@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_3283621_1	1185652.USDA257_c10780	2.897e-156	503.0	COG0241@1|root,COG1208@1|root,COG0241@2|Bacteria,COG1208@2|Bacteria,1RDGR@1224|Proteobacteria,2TRW1@28211|Alphaproteobacteria,4BHCQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	EJM	HAD-hyrolase-like	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_6,Hydrolase_like,NTP_transferase,PRK
HFD1_k127_3283621_3	1267535.KB906767_gene2208	1.298e-127	439.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia	204432|Acidobacteriia	D	G-rich domain on putative tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR
HFD1_k127_3283621_5	1267535.KB906767_gene2207	1.34e-75	269.0	COG1596@1|root,COG1596@2|Bacteria,3Y57H@57723|Acidobacteria,2JJNS@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD1_k127_3283621_10	1198114.AciX9_0862	6.445e-19	100.0	COG2120@1|root,COG2120@2|Bacteria,3Y7JC@57723|Acidobacteria,2JMVB@204432|Acidobacteriia	204432|Acidobacteriia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_3283621_11	1304877.KI519399_gene3086	3.319e-13	80.0	COG1215@1|root,COG1215@2|Bacteria,1RIJ7@1224|Proteobacteria,2U1KG@28211|Alphaproteobacteria,3JS2R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 2	exoU	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_3283621_4	234267.Acid_0735	2.781e-82	282.0	2EAQY@1|root,334T6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3283621_8	234267.Acid_0736	2.911e-29	121.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_3283621_6	1499967.BAYZ01000009_gene5346	1.425e-68	235.0	COG0432@1|root,COG0432@2|Bacteria,2NPB7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD1_k127_3283621_0	234267.Acid_0738	5.066e-286	892.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HFD1_k127_3297828_0	338969.Rfer_4083	1.417e-310	977.0	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,2VZZU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3297828_3	398767.Glov_3089	4.156e-11	71.0	COG1555@1|root,COG1555@2|Bacteria,1N7MI@1224|Proteobacteria	1224|Proteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HFD1_k127_3297828_1	338969.Rfer_1713	3.396e-263	844.0	2DBW6@1|root,2ZBEP@2|Bacteria,1QZ6S@1224|Proteobacteria	1224|Proteobacteria	C	TIGRFAM decaheme c-type cytochrome, OmcA MtrC family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3297828_2	864073.HFRIS_008716	5.461e-97	323.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,474R8@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	periplasmic	dctP	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HFD1_k127_3299881_2	1379270.AUXF01000007_gene994	0.0005123	43.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000007_gene994|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3299881_1	1267533.KB906735_gene4979	1.3e-60	221.0	COG4270@1|root,COG4270@2|Bacteria,3Y5DS@57723|Acidobacteria	57723|Acidobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3299881_0	1499967.BAYZ01000145_gene6200	8.365e-63	224.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HFD1_k127_3315403_3	234267.Acid_3582	2.37e-157	504.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3315403_2	251221.35211765	1.207e-172	570.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_3315403_9	234267.Acid_5962	7.302e-32	127.0	COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_3315403_4	251221.35211765	8.48e-133	455.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_3315403_1	234267.Acid_4553	2.517e-181	579.0	COG0836@1|root,COG0836@2|Bacteria,3Y2W2@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD1_k127_3315403_5	234267.Acid_4552	4.691e-129	419.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD1_k127_3315403_7	234267.Acid_4551	1.464e-45	170.0	COG2076@1|root,COG2076@2|Bacteria,3Y93B@57723|Acidobacteria	57723|Acidobacteria	P	Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3315403_8	234267.Acid_4550	7.996e-37	149.0	COG2076@1|root,COG2076@2|Bacteria,3Y8G8@57723|Acidobacteria	57723|Acidobacteria	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3315403_11	489825.LYNGBM3L_16230	5.648e-06	56.0	2DCFS@1|root,32TZJ@2|Bacteria,1GD9D@1117|Cyanobacteria,1HFBZ@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3315403_0	234267.Acid_3577	1.119e-248	781.0	COG0249@1|root,COG0249@2|Bacteria,3Y48T@57723|Acidobacteria	57723|Acidobacteria	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
HFD1_k127_3315403_6	234267.Acid_3576	3.044e-72	276.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD1_k127_3316777_5	234267.Acid_0953	5.378e-116	377.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria	57723|Acidobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD1_k127_3316777_2	234267.Acid_0954	6.295e-140	454.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD1_k127_3316777_7	234267.Acid_0955	1.942e-94	317.0	COG1385@1|root,COG1385@2|Bacteria,3Y3XJ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD1_k127_3316777_3	234267.Acid_0816	3.166e-134	451.0	COG0697@1|root,COG0697@2|Bacteria,3Y4NT@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_3316777_10	1234364.AMSF01000085_gene2950	8.366e-16	92.0	COG4485@1|root,COG4485@2|Bacteria,1PDH2@1224|Proteobacteria,1RW0I@1236|Gammaproteobacteria,1XBIQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD1_k127_3316777_4	1267535.KB906767_gene3449	9.15e-122	409.0	COG1494@1|root,COG1494@2|Bacteria,3Y2XJ@57723|Acidobacteria,2JKWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HFD1_k127_3316777_1	234267.Acid_7174	2.671e-143	465.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD1_k127_3316777_0	204669.Acid345_0189	2.913e-149	486.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria,2JKNZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HFD1_k127_3316777_6	234267.Acid_1862	2.826e-114	373.0	COG1211@1|root,COG1211@2|Bacteria,3Y3VR@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD1_k127_3316777_8	234267.Acid_1861	1.051e-74	263.0	COG0245@1|root,COG0245@2|Bacteria,3Y3WG@57723|Acidobacteria	57723|Acidobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HFD1_k127_3324060_2	234267.Acid_6437	4.213e-131	424.0	COG4249@1|root,COG4249@2|Bacteria,3Y6DQ@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD1_k127_3324060_0	234267.Acid_6436	2.868e-315	979.0	COG0457@1|root,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria	57723|Acidobacteria	E	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
HFD1_k127_3324060_1	234267.Acid_6435	5.67e-195	610.0	COG0714@1|root,COG0714@2|Bacteria,3Y3BH@57723|Acidobacteria	57723|Acidobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD1_k127_3335328_1	118161.KB235922_gene1664	2.962e-51	209.0	COG2133@1|root,COG2982@1|root,COG3210@1|root,COG2133@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,1G17Y@1117|Cyanobacteria	1117|Cyanobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,GSDH,Malectin,TIG
HFD1_k127_3335328_2	443143.GM18_1659	7.336e-48	198.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_3,DUF4347,HemolysinCabind,Phosphoesterase,VCBS,fn3
HFD1_k127_3335328_4	469618.FVAG_00961	0.0008598	53.0	COG3210@1|root,COG3210@2|Bacteria,37883@32066|Fusobacteria	32066|Fusobacteria	U	EntS YbdA MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3335328_3	525904.Tter_2777	1.532e-22	113.0	COG2133@1|root,COG3055@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,2NPM4@2323|unclassified Bacteria	2|Bacteria	G	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_35,CBM_6,GSDH,Kelch_1,Kelch_6
HFD1_k127_3335328_0	234267.Acid_0287	1.755e-130	423.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	5.1.3.10,5.1.3.2	ko:K01784,ko:K12454	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984,R04266	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_3342058_12	234267.Acid_4937	8.939e-83	287.0	COG0387@1|root,COG0387@2|Bacteria,3Y66M@57723|Acidobacteria	57723|Acidobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HFD1_k127_3342058_11	234267.Acid_4488	3.36e-91	317.0	29QWH@1|root,30BWY@2|Bacteria,3Y4SG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3342058_2	234267.Acid_4486	4.491e-319	982.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria	57723|Acidobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HFD1_k127_3342058_4	234267.Acid_4485	8.788e-188	619.0	COG0277@1|root,COG0277@2|Bacteria,3Y766@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD1_k127_3342058_5	234267.Acid_3186	1.674e-182	584.0	COG0306@1|root,COG0306@2|Bacteria,3Y3ZW@57723|Acidobacteria	57723|Acidobacteria	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD1_k127_3342058_10	234267.Acid_3187	7.367e-97	320.0	COG1392@1|root,COG1392@2|Bacteria,3Y58U@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD1_k127_3342058_8	234267.Acid_3188	7.88e-137	441.0	COG0037@1|root,COG0037@2|Bacteria,3Y548@57723|Acidobacteria	57723|Acidobacteria	D	PP-loop family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HFD1_k127_3342058_16	1333856.L686_18605	7.684e-12	74.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,1SA5Z@1236|Gammaproteobacteria,1Z17D@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD1_k127_3342058_14	639030.JHVA01000001_gene3181	1.781e-25	123.0	2C6A3@1|root,34625@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3342058_13	1123269.NX02_16040	3.168e-72	257.0	2BVIB@1|root,32QWK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3342058_6	234267.Acid_2312	6.184e-163	523.0	2CI5Q@1|root,2Z7M7@2|Bacteria,3Y3IR@57723|Acidobacteria	57723|Acidobacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HFD1_k127_3342058_15	234267.Acid_2313	2.212e-22	100.0	2EVWN@1|root,33PAB@2|Bacteria,3Y5UR@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3342058_1	234267.Acid_2314	0.0	1054.0	COG3387@1|root,COG3387@2|Bacteria,3Y3QW@57723|Acidobacteria	57723|Acidobacteria	G	Domain of unknown function (DUF5127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127
HFD1_k127_3342058_3	234267.Acid_6500	4.885e-199	634.0	COG2234@1|root,COG2234@2|Bacteria,3Y4CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_3342058_9	1340493.JNIF01000004_gene759	3.866e-108	357.0	COG0667@1|root,COG0667@2|Bacteria,3Y6M9@57723|Acidobacteria	57723|Acidobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_3342058_0	234267.Acid_5900	0.0	1505.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_3342058_7	639030.JHVA01000001_gene2113	1.039e-156	513.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD1_k127_3344184_0	316274.Haur_3580	7.332e-61	239.0	COG2244@1|root,COG2244@2|Bacteria,2G7NK@200795|Chloroflexi,3761V@32061|Chloroflexia	32061|Chloroflexia	S	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
HFD1_k127_3344184_1	383372.Rcas_3103	1.739e-46	188.0	COG3307@1|root,COG3307@2|Bacteria,2GB55@200795|Chloroflexi,377AJ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD1_k127_3344184_3	1123308.KB904538_gene326	0.0009532	50.0	COG3944@1|root,COG3944@2|Bacteria,1V4ZF@1239|Firmicutes,4IR4A@91061|Bacilli	91061|Bacilli	M	Polysaccharide export protein, MPA1 family	cps4C	-	-	-	-	-	-	-	-	-	-	-	Wzz
HFD1_k127_3344184_2	1049564.TevJSym_ag00490	3.714e-15	80.0	COG4623@1|root,COG4623@2|Bacteria,1QUQJ@1224|Proteobacteria,1T218@1236|Gammaproteobacteria,1JBK3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD1_k127_3345086_3	234267.Acid_1356	2.588e-55	198.0	COG0457@1|root,COG0457@2|Bacteria,3Y4KP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3345086_8	1121918.ARWE01000001_gene3027	1.782e-12	75.0	2FDAJ@1|root,345CF@2|Bacteria,1P36N@1224|Proteobacteria,4314V@68525|delta/epsilon subdivisions,2WX3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3345086_5	316056.RPC_1006	4.061e-23	108.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HFD1_k127_3345086_0	243231.GSU0775	1.009e-107	377.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
HFD1_k127_3345086_6	1499967.BAYZ01000059_gene4769	1.101e-19	97.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD1_k127_3345086_2	644282.Deba_1749	2.124e-66	242.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43C2A@68525|delta/epsilon subdivisions,2X7CW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HFD1_k127_3345086_4	644282.Deba_1750	4.663e-26	113.0	COG0745@1|root,COG0745@2|Bacteria,1RINR@1224|Proteobacteria,42T1R@68525|delta/epsilon subdivisions,2WPHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_3345086_7	552811.Dehly_0411	1.263e-14	83.0	COG0680@1|root,COG0680@2|Bacteria,2G7BV@200795|Chloroflexi,34D7G@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HFD1_k127_3345086_1	374847.Kcr_0321	8.041e-93	322.0	COG0374@1|root,arCOG01549@2157|Archaea	2157|Archaea	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hydA	GO:0003674,GO:0005488,GO:0005575,GO:0016151,GO:0032991,GO:0043167,GO:0043169,GO:0044569,GO:0046872,GO:0046914,GO:1902494	1.12.1.3,1.12.1.5,1.8.98.5	ko:K14126,ko:K17993	ko00680,ko00920,map00680,map00920	-	R00019,R10390,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HFD1_k127_3345086_9	1183377.Py04_1130	2.429e-08	57.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,24315@183968|Thermococci	183968|Thermococci	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.3,1.12.1.5	ko:K17994	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HFD1_k127_3357652_0	234267.Acid_2092	1.877e-283	874.0	COG2272@1|root,COG2272@2|Bacteria,3Y3YC@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_3357652_11	1340493.JNIF01000003_gene4042	6.48e-10	65.0	COG1629@1|root,COG1629@2|Bacteria,3Y765@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3357652_8	1340493.JNIF01000004_gene564	5.849e-20	93.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3357652_7	234267.Acid_2985	6.207e-90	308.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_3357652_5	234267.Acid_2984	1.123e-187	595.0	COG4948@1|root,COG4948@2|Bacteria,3Y6CG@57723|Acidobacteria	2|Bacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, N-terminal domain protein	dgoD	GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.1.2.21,4.2.1.6	ko:K01631,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R01064,R03033	RC00307,RC00435,RC00543	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b4478,iB21_1397.B21_03519,iBWG_1329.BWG_3382,iEC042_1314.EC042_4048,iEC55989_1330.EC55989_4161,iECBD_1354.ECBD_0011,iECB_1328.ECB_03575,iECDH10B_1368.ECDH10B_3878,iECDH1ME8569_1439.ECDH1ME8569_3579,iECD_1391.ECD_03575,iECIAI1_1343.ECIAI1_3870,iECO103_1326.ECO103_4466,iECO111_1330.ECO111_4519,iECSE_1348.ECSE_3978,iECUMN_1333.ECUMN_4223,iECW_1372.ECW_m3991,iEKO11_1354.EKO11_0011,iETEC_1333.ETEC_3982,iEcDH1_1363.EcDH1_0011,iEcE24377_1341.EcE24377A_4201,iEcSMS35_1347.EcSMS35_4057,iEcolC_1368.EcolC_0011,iJO1366.b4478,iWFL_1372.ECW_m3991,iY75_1357.Y75_RS18645	MR_MLE_C,MR_MLE_N
HFD1_k127_3357652_13	1123278.KB893566_gene2182	0.0001475	44.0	COG4948@1|root,COG4948@2|Bacteria,4NE9A@976|Bacteroidetes,47NDY@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_3357652_10	266117.Rxyl_3008	9.154e-12	69.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria,4CT8G@84995|Rubrobacteria	84995|Rubrobacteria	M	PFAM Mandelate racemase muconate lactonizing	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_3357652_4	1168289.AJKI01000010_gene1586	6.083e-191	603.0	COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,2G1C4@200643|Bacteroidia,3XKSQ@558415|Marinilabiliaceae	976|Bacteroidetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_3357652_1	234267.Acid_2106	2.39e-279	868.0	COG2272@1|root,COG2272@2|Bacteria,3Y3ME@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_3357652_12	583355.Caka_0507	1.405e-06	54.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
HFD1_k127_3357652_6	234267.Acid_2990	1.41e-92	308.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3357652_2	234267.Acid_2989	1.136e-256	798.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
HFD1_k127_3357652_3	234267.Acid_2990	3.82e-224	703.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3357652_9	234267.Acid_2993	3.992e-16	79.0	COG3507@1|root,COG3507@2|Bacteria,3Y6BR@57723|Acidobacteria	57723|Acidobacteria	G	family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_3359760_3	1499967.BAYZ01000097_gene4350	1.045e-06	50.0	COG4826@1|root,COG4826@2|Bacteria,2NQVB@2323|unclassified Bacteria	2|Bacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HFD1_k127_3359760_0	929562.Emtol_2237	8.442e-103	341.0	2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,47M8V@768503|Cytophagia	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_3359760_1	234267.Acid_6610	3.818e-101	343.0	COG0515@1|root,COG0515@2|Bacteria,3Y6PF@57723|Acidobacteria	57723|Acidobacteria	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_3362557_5	234267.Acid_2610	2.401e-14	73.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_3362557_2	234267.Acid_5757	6.948e-58	209.0	COG1595@1|root,COG1595@2|Bacteria,3Y8YQ@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3362557_1	234267.Acid_5756	3.671e-78	280.0	COG0515@1|root,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria	57723|Acidobacteria	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD1_k127_3362557_3	234267.Acid_5754	6.038e-50	183.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HFD1_k127_3362557_0	639030.JHVA01000001_gene2540	7.025e-104	345.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_3368125_1	509191.AEDB02000022_gene2935	4.552e-79	280.0	COG2006@1|root,COG2006@2|Bacteria,1VRZ8@1239|Firmicutes,24Z9V@186801|Clostridia,3WN5G@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Dockerin_1
HFD1_k127_3368125_2	604354.TSIB_0325	1.183e-33	148.0	arCOG08626@1|root,arCOG08626@2157|Archaea,2Y4FM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3368125_0	234267.Acid_6289	1.186e-232	726.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501,Sulfatase
HFD1_k127_3369735_1	234267.Acid_0327	5.303e-57	217.0	COG1344@1|root,COG1344@2|Bacteria,3Y4AW@57723|Acidobacteria	57723|Acidobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HFD1_k127_3369735_0	1173025.GEI7407_0339	1.209e-103	356.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD1_k127_3372716_0	1267535.KB906767_gene1553	3.026e-216	692.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
HFD1_k127_3372716_1	497964.CfE428DRAFT_4151	2.772e-170	557.0	COG4692@1|root,COG4692@2|Bacteria,46SE5@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,VCBS
HFD1_k127_3372716_2	97139.C824_02719	3.815e-18	92.0	COG1479@1|root,COG1479@2|Bacteria,1VHC8@1239|Firmicutes,24PSV@186801|Clostridia,36W3S@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
HFD1_k127_3386734_4	234267.Acid_0669	1.16e-14	76.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_3386734_1	234267.Acid_5880	3.09e-74	256.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TIR_2
HFD1_k127_3386734_5	204669.Acid345_4704	0.0006473	47.0	COG0776@1|root,COG0776@2|Bacteria,3Y93V@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_3386734_2	234267.Acid_5883	3.97e-58	209.0	COG1959@1|root,COG1959@2|Bacteria,3Y87Y@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD1_k127_3386734_0	234267.Acid_5884	3.768e-156	507.0	COG0031@1|root,COG0031@2|Bacteria,3Y45Z@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_3386734_3	234267.Acid_5885	9.147e-41	162.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HFD1_k127_3392345_0	234267.Acid_1754	8.024e-196	615.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_3392345_1	234267.Acid_1753	2.392e-111	381.0	2BZ8T@1|root,33VM1@2|Bacteria,3Y7Y3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3392345_2	234267.Acid_1752	3.82e-52	188.0	2CBQR@1|root,32RTV@2|Bacteria,3Y57Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3408863_1	234267.Acid_6427	8.761e-197	621.0	COG1032@1|root,COG1032@2|Bacteria,3Y7DR@57723|Acidobacteria	57723|Acidobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD1_k127_3408863_11	1121927.GOHSU_17_00060	9.18e-06	54.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4GDQH@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	hrrA2	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_3408863_5	234267.Acid_7914	3.058e-74	266.0	COG0457@1|root,COG0457@2|Bacteria,3Y7TN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3408863_6	216594.MMAR_2904	1.235e-58	229.0	COG3315@1|root,COG3315@2|Bacteria,2GNGD@201174|Actinobacteria,234ZU@1762|Mycobacteriaceae	201174|Actinobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HFD1_k127_3408863_3	1267535.KB906767_gene2547	5.387e-116	394.0	COG1807@1|root,COG1807@2|Bacteria,3Y2UV@57723|Acidobacteria,2JIS6@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_3408863_9	234267.Acid_7477	1.752e-37	149.0	2E8MJ@1|root,32S5J@2|Bacteria,3Y53W@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF3467)	-	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	DUF3467
HFD1_k127_3408863_8	525904.Tter_0841	2.798e-51	194.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	ocd	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD1_k127_3408863_0	234267.Acid_7478	0.0	1031.0	COG0488@1|root,COG0488@2|Bacteria,3Y340@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HFD1_k127_3408863_4	234267.Acid_7479	1.65e-99	332.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_3408863_7	234267.Acid_7482	2.147e-57	202.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria	57723|Acidobacteria	K	PFAM regulatory protein, MerR	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HFD1_k127_3408863_2	234267.Acid_7483	1.894e-195	615.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD1_k127_3408863_10	234267.Acid_7484	1.383e-23	102.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria	57723|Acidobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD1_k127_3409680_1	335543.Sfum_0219	5.554e-153	504.0	COG0457@1|root,COG3118@1|root,COG3379@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42XTF@68525|delta/epsilon subdivisions,2WSZG@28221|Deltaproteobacteria,2MRX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_3409680_2	1205680.CAKO01000002_gene2850	3.22e-98	332.0	COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HFD1_k127_3409680_0	234267.Acid_6686	8.152e-234	732.0	COG0248@1|root,COG0248@2|Bacteria,3Y3H5@57723|Acidobacteria	57723|Acidobacteria	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HFD1_k127_3409680_4	661478.OP10G_0668	2.996e-71	252.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204,NTP_transf_5
HFD1_k127_3409680_3	661478.OP10G_0669	3.558e-93	313.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_3415760_0	234267.Acid_4916	0.0	1228.0	COG1629@1|root,COG4771@2|Bacteria,3Y9AT@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_3415760_10	234267.Acid_4915	2.851e-97	329.0	COG0584@1|root,COG0584@2|Bacteria,3Y40Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD1_k127_3415760_16	1487953.JMKF01000066_gene3764	1.473e-28	123.0	COG4636@1|root,COG4636@2|Bacteria,1G599@1117|Cyanobacteria,1HH92@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_3415760_18	234267.Acid_2380	1.243e-27	130.0	COG2133@1|root,COG3292@1|root,COG2133@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,CHB_HEX_C_1,DUF1906,Glyco_hydro_18,Malectin,PA14,SLH,VCBS
HFD1_k127_3415760_6	682795.AciX8_2232	2.079e-137	458.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3415760_9	1349767.GJA_3077	9.212e-99	354.0	COG3507@1|root,COG3507@2|Bacteria,1R5VX@1224|Proteobacteria,2W0XY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,RicinB_lectin_2
HFD1_k127_3415760_2	278963.ATWD01000001_gene3345	9.239e-288	920.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3415760_7	1340493.JNIF01000003_gene3431	9.926e-121	401.0	COG3609@1|root,COG3609@2|Bacteria,3Y64I@57723|Acidobacteria	57723|Acidobacteria	K	addiction module antidote protein, CC2985 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3415760_17	234267.Acid_0500	3.546e-28	116.0	2DR0H@1|root,339NS@2|Bacteria,3Y59F@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD1_k127_3415760_12	1340493.JNIF01000004_gene143	7.367e-81	275.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD1_k127_3415760_1	234267.Acid_0498	3.66e-321	988.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD1_k127_3415760_5	234267.Acid_0497	4.894e-165	524.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD1_k127_3415760_8	234267.Acid_0496	7.417e-118	394.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD1_k127_3415760_15	234267.Acid_0495	1.057e-36	145.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3415760_4	234267.Acid_0494	1.066e-171	553.0	COG4531@1|root,COG4531@2|Bacteria,3Y2X7@57723|Acidobacteria	57723|Acidobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3415760_11	234267.Acid_0493	1.804e-86	296.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_3415760_13	234267.Acid_0492	3.014e-49	176.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD1_k127_3415760_14	234267.Acid_0492	2.283e-39	148.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD1_k127_3415760_3	234267.Acid_0491	6.407e-195	610.0	COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD1_k127_341645_1	234267.Acid_7187	8.821e-142	459.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD1_k127_341645_0	234267.Acid_0067	4.375e-203	638.0	COG0174@1|root,COG0174@2|Bacteria	2|Bacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD1_k127_3427430_3	204669.Acid345_4082	3.767e-12	68.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria,2JKG1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3427430_0	234267.Acid_6795	1.43e-80	291.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD1_k127_3427430_2	234267.Acid_2888	2.053e-13	79.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,PagL
HFD1_k127_3427430_1	205922.Pfl01_1375	2.39e-27	120.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HFD1_k127_3448677_2	234267.Acid_0470	7.405e-41	168.0	COG1361@1|root,COG3391@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3391@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	57723|Acidobacteria	M	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
HFD1_k127_3448677_3	521098.Aaci_1325	8.429e-41	173.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,277VY@186823|Alicyclobacillaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HFD1_k127_3448677_1	234267.Acid_7851	3.157e-82	302.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3448677_0	1340493.JNIF01000004_gene878	1.185e-253	801.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,3Y77C@57723|Acidobacteria	57723|Acidobacteria	G	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Peptidase_C14,TPR_2,WD40
HFD1_k127_3464021_3	234267.Acid_3286	1.314e-35	138.0	COG0577@1|root,COG0577@2|Bacteria,3Y44N@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3464021_5	1267533.KB906733_gene2926	2.777e-30	124.0	COG3801@1|root,COG3801@2|Bacteria,3Y5K2@57723|Acidobacteria,2JNJG@204432|Acidobacteriia	204432|Acidobacteriia	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD1_k127_3464021_0	234267.Acid_4577	5.391e-185	594.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_3464021_4	1267535.KB906767_gene1286	2.59e-34	141.0	COG2010@1|root,COG2010@2|Bacteria,3Y846@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_3464021_2	1267535.KB906767_gene5109	5.709e-54	190.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_3464021_1	234267.Acid_0762	1.775e-69	254.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3467187_0	1121405.dsmv_3774	1.829e-242	765.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MJFX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.17.1.4	ko:K00087,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD1_k127_3467187_2	706587.Desti_3921	3.665e-65	232.0	COG2080@1|root,COG2080@2|Bacteria,1MY3F@1224|Proteobacteria,43AMR@68525|delta/epsilon subdivisions,2X61U@28221|Deltaproteobacteria,2MRMX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	2Fe-2S -binding domain	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2
HFD1_k127_3467187_5	414684.RC1_1944	1.466e-10	67.0	2E46S@1|root,32Z2Q@2|Bacteria,1N7X1@1224|Proteobacteria,2UUK2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3467187_6	306281.AJLK01000100_gene3894	4.529e-10	62.0	2B72Y@1|root,3203V@2|Bacteria,1GKKJ@1117|Cyanobacteria,1JMDJ@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3467187_3	880074.BARVI_08635	8.76e-39	152.0	COG0778@1|root,COG0778@2|Bacteria,4NP0K@976|Bacteroidetes,2FPFS@200643|Bacteroidia,22Y36@171551|Porphyromonadaceae	976|Bacteroidetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD1_k127_3467187_4	1123024.AUII01000022_gene110	1.139e-24	117.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria,4EF7E@85010|Pseudonocardiales	201174|Actinobacteria	LT	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
HFD1_k127_3467187_1	234267.Acid_0872	2.397e-75	274.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3471174_2	234267.Acid_7509	7.519e-100	332.0	COG1082@1|root,COG1082@2|Bacteria,3Y51R@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_3471174_0	234267.Acid_6646	1.671e-204	647.0	COG0641@1|root,COG0641@2|Bacteria,3Y8KB@57723|Acidobacteria	57723|Acidobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
HFD1_k127_3471174_6	1185876.BN8_00548	2.343e-35	153.0	COG2244@1|root,COG2244@2|Bacteria,4NIKA@976|Bacteroidetes	976|Bacteroidetes	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3471174_5	1032480.MLP_27070	3.776e-38	153.0	COG0500@1|root,COG2226@2|Bacteria,2IC3Q@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD1_k127_3471174_1	234267.Acid_5206	2.012e-134	432.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_3471174_9	1382304.JNIL01000001_gene1872	1.471e-13	83.0	COG4194@1|root,COG4194@2|Bacteria,1UY2R@1239|Firmicutes,4HEEQ@91061|Bacilli	91061|Bacilli	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
HFD1_k127_3471174_8	189425.PGRAT_02860	4.552e-15	83.0	COG1725@1|root,COG1725@2|Bacteria,1V743@1239|Firmicutes,4HMKR@91061|Bacilli,274VA@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HFD1_k127_3471174_3	234267.Acid_2699	6.632e-91	315.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AhpC-TSA,CarboxypepD_reg,PDZ_2,Plug,TonB_dep_Rec
HFD1_k127_3471174_7	234267.Acid_2699	5.162e-23	101.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AhpC-TSA,CarboxypepD_reg,PDZ_2,Plug,TonB_dep_Rec
HFD1_k127_3481711_6	234267.Acid_7944	8.248e-113	375.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_3	234267.Acid_0004	5.089e-203	647.0	COG0457@1|root,COG0457@2|Bacteria,3Y3D1@57723|Acidobacteria	57723|Acidobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_16	216596.RL1944	3.641e-25	118.0	COG1403@1|root,COG1403@2|Bacteria,1PAQC@1224|Proteobacteria,2U34W@28211|Alphaproteobacteria,4BH3I@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_18	1382359.JIAL01000001_gene53	1.43e-17	96.0	28Q1U@1|root,2ZCK2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HFD1_k127_3481711_14	671143.DAMO_2920	1.018e-32	134.0	2DRSH@1|root,33CVS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_0	234267.Acid_0012	0.0	2008.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD1_k127_3481711_21	246196.MSMEI_1628	5.244e-07	56.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,23511@1762|Mycobacteriaceae	201174|Actinobacteria	L	carboxymuconolactone decarboxylase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
HFD1_k127_3481711_15	1123023.JIAI01000001_gene6793	1.794e-30	123.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ynjA	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_3481711_19	234267.Acid_1158	1.076e-16	91.0	2E71G@1|root,331K5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_13	234267.Acid_1158	4.88e-44	164.0	2E71G@1|root,331K5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3481711_10	234267.Acid_4099	1.156e-59	226.0	COG0515@1|root,COG0515@2|Bacteria,3Y5DE@57723|Acidobacteria	57723|Acidobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,SPOR
HFD1_k127_3481711_12	234267.Acid_4100	7.058e-52	190.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD1_k127_3481711_20	861299.J421_1411	1.138e-15	89.0	COG1231@1|root,COG1231@2|Bacteria	2|Bacteria	E	oxidoreductase activity	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_3481711_4	234267.Acid_0014	3.062e-175	557.0	COG0151@1|root,COG0151@2|Bacteria,3Y6E1@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD1_k127_3481711_1	1340493.JNIF01000003_gene2687	1.395e-273	861.0	COG0445@1|root,COG0445@2|Bacteria,3Y3E4@57723|Acidobacteria	57723|Acidobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HFD1_k127_3481711_17	743721.Psesu_2850	3.805e-22	104.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1X4ZH@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD1_k127_3481711_5	234267.Acid_0016	3.926e-128	413.0	COG1192@1|root,COG1192@2|Bacteria,3Y2Y2@57723|Acidobacteria	57723|Acidobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD1_k127_3481711_7	234267.Acid_0017	1.748e-91	312.0	COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD1_k127_3481711_11	234267.Acid_0018	3.379e-59	207.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria	57723|Acidobacteria	K	regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD1_k127_3481711_8	356851.JOAN01000020_gene4011	3.035e-89	304.0	COG4122@1|root,COG4122@2|Bacteria,2IARG@201174|Actinobacteria,4DKAV@85008|Micromonosporales	201174|Actinobacteria	H	Macrocin-O-methyltransferase (TylF)	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0030769,GO:0032259,GO:0044237,GO:0044249	2.1.1.101,2.1.1.307	ko:K05303,ko:K15996,ko:K19569	ko00522,ko01057,ko01130,map00522,map01057,map01130	M00773,M00784	R02858,R10958	RC00003,RC00466	ko00000,ko00001,ko00002,ko01000	-	-	-	TylF
HFD1_k127_3481711_2	195250.CM001776_gene1279	3.14e-230	763.0	COG0438@1|root,COG1196@1|root,COG1216@1|root,COG3551@1|root,COG0438@2|Bacteria,COG1196@2|Bacteria,COG1216@2|Bacteria,COG3551@2|Bacteria,1G0TI@1117|Cyanobacteria,1GYRA@1129|Synechococcus	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2
HFD1_k127_3481711_9	1442599.JAAN01000035_gene708	1.016e-64	254.0	COG4122@1|root,COG4122@2|Bacteria,1RB4I@1224|Proteobacteria,1S0WP@1236|Gammaproteobacteria,1X651@135614|Xanthomonadales	135614|Xanthomonadales	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HFD1_k127_3481711_22	742733.HMPREF9469_05267	3.575e-05	53.0	COG1216@1|root,COG1216@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia,21YBN@1506553|Lachnoclostridium	186801|Clostridia	M	COG COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
HFD1_k127_3499505_1	234267.Acid_0646	6.834e-121	389.0	COG1484@1|root,COG1484@2|Bacteria,3Y6NW@57723|Acidobacteria	57723|Acidobacteria	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HFD1_k127_3499505_0	1210884.HG799469_gene14163	2.104e-143	472.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_3499505_4	530564.Psta_2542	4.871e-71	257.0	COG1520@1|root,COG1520@2|Bacteria,2IXXG@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_3499505_2	314230.DSM3645_20627	2.477e-113	380.0	COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_3499505_3	234267.Acid_0872	4.079e-85	301.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3527222_3	234267.Acid_3886	2.572e-35	136.0	COG1764@1|root,COG1764@2|Bacteria,3Y4TU@57723|Acidobacteria	57723|Acidobacteria	O	PFAM OsmC family protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HFD1_k127_3527222_0	234267.Acid_3949	0.0	1203.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria	57723|Acidobacteria	M	Surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HFD1_k127_3527222_2	234267.Acid_3948	1.373e-40	157.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	nifM	-	2.3.1.39,5.2.1.8	ko:K00645,ko:K01802,ko:K02597,ko:K03769,ko:K03770,ko:K03771	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD1_k127_3527222_1	234267.Acid_3947	1.819e-98	339.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
HFD1_k127_3533464_3	1340493.JNIF01000003_gene1948	1.305e-47	177.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_3533464_0	32057.KB217478_gene2266	4.623e-133	432.0	COG0500@1|root,COG2226@2|Bacteria,1GQ2Q@1117|Cyanobacteria,1HKP3@1161|Nostocales	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD1_k127_3533464_1	234267.Acid_2514	2.459e-88	301.0	2AMVA@1|root,31CS1@2|Bacteria,3Y7GD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3533464_2	234267.Acid_5749	8.017e-75	275.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_3544692_4	452637.Oter_3730	8.464e-58	216.0	COG3509@1|root,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,Esterase_phd
HFD1_k127_3544692_5	1298880.AUEV01000001_gene6026	1.807e-53	200.0	COG1216@1|root,COG1216@2|Bacteria,2IAFY@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_3544692_2	401053.AciPR4_0483	2.958e-105	355.0	COG4219@1|root,COG4219@2|Bacteria,3Y73G@57723|Acidobacteria,2JKMG@204432|Acidobacteriia	204432|Acidobacteriia	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_3544692_7	700598.Niako_3558	4.185e-11	66.0	COG3832@1|root,COG3832@2|Bacteria,4NSDK@976|Bacteroidetes,1ITI0@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_3544692_0	234267.Acid_4149	1.98e-284	895.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	2|Bacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3544692_1	234267.Acid_2798	1.499e-109	372.0	COG3509@1|root,COG3509@2|Bacteria,3Y3SY@57723|Acidobacteria	57723|Acidobacteria	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HFD1_k127_3544692_3	234267.Acid_6208	2.493e-87	290.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
HFD1_k127_3556051_1	886293.Sinac_1527	1.471e-23	108.0	COG1477@1|root,COG1477@2|Bacteria,2IYYX@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD1_k127_3556051_0	234267.Acid_0197	2.989e-64	232.0	COG5616@1|root,COG5616@2|Bacteria,3Y4NN@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3563478_1	1267535.KB906767_gene2278	5.343e-156	501.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD1_k127_3563478_5	234267.Acid_3739	1.124e-44	171.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_3563478_3	234267.Acid_2361	9.309e-79	271.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_3563478_4	234267.Acid_1284	5.363e-70	251.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HFD1_k127_3563478_7	234267.Acid_1032	1.182e-22	111.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
HFD1_k127_3563478_6	570952.ATVH01000015_gene1427	9.429e-44	173.0	COG4552@1|root,COG4552@2|Bacteria,1R68I@1224|Proteobacteria,2U9V8@28211|Alphaproteobacteria,2JWFU@204441|Rhodospirillales	204441|Rhodospirillales	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3563478_0	234267.Acid_4451	3.779e-190	613.0	COG0673@1|root,COG0673@2|Bacteria,3Y71T@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_3563478_2	234267.Acid_5530	6.869e-119	385.0	COG0475@1|root,COG0475@2|Bacteria,3Y5D3@57723|Acidobacteria	57723|Acidobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD1_k127_3563994_2	234267.Acid_5825	7.727e-94	317.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	moxJ	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,SBP_bac_3
HFD1_k127_3563994_0	742727.HMPREF9447_01811	6.749e-197	626.0	COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,2FNPT@200643|Bacteroidia,4AM5V@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
HFD1_k127_3563994_1	1123242.JH636434_gene5275	2.296e-148	490.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HFD1_k127_3563994_3	861299.J421_5621	2.619e-89	303.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_3563994_4	1267533.KB906736_gene1246	1.745e-35	139.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_3567292_2	234267.Acid_2613	2.229e-140	455.0	COG0577@1|root,COG0577@2|Bacteria,3Y7GM@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3567292_1	234267.Acid_2175	4.71e-166	528.0	COG0673@1|root,COG0673@2|Bacteria,3Y32B@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_3567292_4	1340493.JNIF01000004_gene301	3.036e-125	424.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_3567292_5	234267.Acid_4592	3.584e-91	305.0	COG4445@1|root,COG4445@2|Bacteria,3Y8RX@57723|Acidobacteria	57723|Acidobacteria	FJ	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	-	-	-	ko:K06169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MiaE
HFD1_k127_3567292_0	1120949.KB903298_gene5794	1.952e-267	832.0	COG1502@1|root,COG1502@2|Bacteria,2GKHR@201174|Actinobacteria	201174|Actinobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD1_k127_3567292_3	1340493.JNIF01000004_gene277	1.77e-139	445.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_3572476_0	234267.Acid_5827	2.293e-225	708.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD1_k127_3572476_1	886293.Sinac_1154	3.747e-204	668.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD1_k127_3572476_2	886293.Sinac_1155	4.518e-55	216.0	COG0666@1|root,COG0666@2|Bacteria,2J1F8@203682|Planctomycetes	203682|Planctomycetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD1_k127_3575948_19	234267.Acid_1754	2.464e-64	224.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_3575948_2	1340493.JNIF01000003_gene2321	6.481e-243	790.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y6I3@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3575948_9	234267.Acid_1755	3.336e-132	424.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria	57723|Acidobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_3575948_8	234267.Acid_1756	1.928e-155	492.0	COG1378@1|root,COG1378@2|Bacteria,3Y66F@57723|Acidobacteria	57723|Acidobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
HFD1_k127_3575948_7	234267.Acid_1759	4.63e-181	570.0	COG0463@1|root,COG0463@2|Bacteria,3Y30V@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_3575948_16	234267.Acid_1760	1.663e-84	283.0	COG0566@1|root,COG0566@2|Bacteria,3Y4WG@57723|Acidobacteria	57723|Acidobacteria	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
HFD1_k127_3575948_6	234267.Acid_1761	1.526e-182	578.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria	57723|Acidobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HFD1_k127_3575948_21	1267535.KB906767_gene2418	1.552e-27	120.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	mccA	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.1,6.4.1.3,6.4.1.4	ko:K01960,ko:K01965,ko:K01968	ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230	M00036,M00173,M00373,M00620,M00741	R00344,R01859,R04138	RC00040,RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HFD1_k127_3575948_1	234267.Acid_1858	1.799e-251	786.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria	57723|Acidobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD1_k127_3575948_15	234267.Acid_1857	1.169e-90	300.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD1_k127_3575948_3	234267.Acid_1856	6.947e-238	751.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
HFD1_k127_3575948_22	234267.Acid_2553	3.246e-21	108.0	2FC9W@1|root,344DJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3575948_14	443143.GM18_1305	1.814e-102	346.0	COG4872@1|root,COG4872@2|Bacteria,1NF4D@1224|Proteobacteria,42XRT@68525|delta/epsilon subdivisions,2WXTA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HFD1_k127_3575948_4	234267.Acid_1276	7.409e-214	667.0	COG0343@1|root,COG0343@2|Bacteria,3Y3CP@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD1_k127_3575948_20	234267.Acid_1277	3.387e-32	128.0	COG1862@1|root,COG1862@2|Bacteria,3Y5GK@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase, YajC	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD1_k127_3575948_0	234267.Acid_1278	3.762e-273	848.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD1_k127_3575948_13	1340493.JNIF01000003_gene1850	1.174e-108	364.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD1_k127_3575948_12	234267.Acid_1280	5.584e-115	376.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_3575948_10	234267.Acid_1281	1.172e-130	420.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HFD1_k127_3575948_18	234267.Acid_1282	2.723e-66	229.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD1_k127_3575948_17	234267.Acid_1283	4.072e-68	234.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD1_k127_3575948_11	234267.Acid_1284	7.448e-123	398.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HFD1_k127_3575948_5	234267.Acid_1285	1.27e-188	592.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria	57723|Acidobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD1_k127_3578091_4	234267.Acid_1655	1.871e-94	313.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3578091_3	234267.Acid_1654	2.501e-163	522.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_3578091_2	234267.Acid_3640	1.26e-259	826.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	234267.Acid_3640|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3578091_1	1340493.JNIF01000003_gene1733	4.077e-266	845.0	COG0308@1|root,COG0308@2|Bacteria,3Y2XM@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HFD1_k127_3578091_0	234267.Acid_3106	1.11e-286	887.0	28HBM@1|root,2Z7NK@2|Bacteria,3Y6H0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3583940_2	744980.TRICHSKD4_5980	9.654e-60	209.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HFD1_k127_3583940_0	1502851.FG93_04584	2.965e-210	660.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,3JRID@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	-	-	3.3.2.9	ko:K01253,ko:K21159	ko00980,ko01059,ko04976,ko05204,map00980,map01059,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
HFD1_k127_3583940_1	1287116.X734_23570	6.056e-126	425.0	COG0526@1|root,COG0526@2|Bacteria,1QTY9@1224|Proteobacteria,2TW6Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,NHL,Redoxin,Thioredoxin_8
HFD1_k127_3595232_1	1340493.JNIF01000003_gene1473	7.69e-85	296.0	COG5616@1|root,COG5616@2|Bacteria,3Y4NN@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3595232_0	234267.Acid_5952	9.865e-111	383.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_360464_0	1267535.KB906767_gene721	9.495e-61	224.0	COG0651@1|root,COG0651@2|Bacteria	2|Bacteria	CP	ATP synthesis coupled electron transport	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HFD1_k127_360464_1	234267.Acid_3958	6.781e-31	126.0	299QU@1|root,2ZWT2@2|Bacteria,3Y915@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_360464_2	330214.NIDE0222	3.307e-07	54.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
HFD1_k127_3612505_1	234267.Acid_0605	4.921e-218	695.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria	57723|Acidobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD1_k127_3612505_6	1396418.BATQ01000091_gene5814	2.251e-16	84.0	COG1917@1|root,COG1917@2|Bacteria,46VBI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_3612505_2	234267.Acid_2700	4.878e-129	415.0	COG1028@1|root,COG1028@2|Bacteria,3Y6NJ@57723|Acidobacteria	57723|Acidobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_3612505_4	234267.Acid_2701	1.069e-81	280.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD1_k127_3612505_3	234267.Acid_2702	9.997e-101	336.0	COG3597@1|root,COG3597@2|Bacteria,3Y7Z9@57723|Acidobacteria	57723|Acidobacteria	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3612505_0	234267.Acid_2703	1.377e-218	687.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3612505_5	1288963.ADIS_1386	8.046e-63	230.0	28HHT@1|root,2Z7TE@2|Bacteria,4NIHS@976|Bacteroidetes,47MAA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_361947_13	1267535.KB906767_gene948	1.529e-12	73.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria,2JKA2@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
HFD1_k127_361947_12	1267535.KB906767_gene4235	2.565e-14	77.0	COG1506@1|root,COG1506@2|Bacteria,3Y6QI@57723|Acidobacteria	57723|Acidobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_361947_11	234267.Acid_6090	1.012e-24	106.0	COG1506@1|root,COG1506@2|Bacteria,3Y6QI@57723|Acidobacteria	57723|Acidobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_361947_7	1267535.KB906767_gene1640	6.566e-51	183.0	2D76U@1|root,32TNF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_361947_4	1185876.BN8_03564	5.69e-85	295.0	COG1312@1|root,COG1312@2|Bacteria,4NIMS@976|Bacteroidetes,47JVK@768503|Cytophagia	976|Bacteroidetes	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HFD1_k127_361947_8	395493.BegalDRAFT_2565	1.451e-49	199.0	2BZSF@1|root,32R5M@2|Bacteria,1N2M2@1224|Proteobacteria,1SACN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_361947_2	1234595.C725_0323	3.536e-116	392.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Cytochrom_C,DUF1349,F5_F8_type_C,Glyco_hydro_32N,Glyco_hydro_81
HFD1_k127_361947_3	234267.Acid_3069	2.49e-107	361.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Barstar,CBM_48,Esterase
HFD1_k127_361947_1	1340493.JNIF01000003_gene1813	1.446e-152	496.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_361947_5	660470.Theba_0060	7.169e-83	292.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_361947_0	234267.Acid_6854	0.0	1127.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_361947_10	926569.ANT_09010	2.413e-31	136.0	COG2222@1|root,COG2222@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
HFD1_k127_361947_9	1267535.KB906767_gene3676	6.732e-36	147.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD1_k127_361947_6	344747.PM8797T_06275	1.724e-67	256.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
HFD1_k127_3628847_5	1048983.EL17_00520	2.206e-36	149.0	28N78@1|root,2ZBBY@2|Bacteria,4NGF9@976|Bacteroidetes,47X4G@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4932
HFD1_k127_3628847_4	234267.Acid_0381	6.886e-42	156.0	COG4577@1|root,COG4577@2|Bacteria	234267.Acid_0381|-	CQ	ethanolamine catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3628847_0	234267.Acid_0382	1.765e-265	826.0	COG1012@1|root,COG1012@2|Bacteria,3Y3MS@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
HFD1_k127_3628847_1	234267.Acid_0384	1.831e-262	818.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria	57723|Acidobacteria	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HFD1_k127_3628847_3	344747.PM8797T_15161	2.44e-54	200.0	COG0673@1|root,COG0673@2|Bacteria,2IXE4@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_3635777_1	879212.DespoDRAFT_02565	3.353e-08	60.0	COG5551@1|root,COG5551@2|Bacteria,1R5YY@1224|Proteobacteria,42RTI@68525|delta/epsilon subdivisions,2WNT5@28221|Deltaproteobacteria,2MN6T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	CRISPR-associated endoribonuclease Cas6	-	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas6
HFD1_k127_3635777_0	886293.Sinac_6050	1.329e-90	308.0	2DMFF@1|root,32R5F@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3639301_0	404589.Anae109_1606	1.601e-185	592.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,437ZU@68525|delta/epsilon subdivisions,2X39R@28221|Deltaproteobacteria,2YV0T@29|Myxococcales	28221|Deltaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HFD1_k127_3639301_1	1162668.LFE_2270	1.111e-69	254.0	COG2801@1|root,COG2801@2|Bacteria,3J1E8@40117|Nitrospirae	2|Bacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
HFD1_k127_3642501_0	1126627.BAWE01000004_gene2834	7.525e-155	504.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3K6A5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
HFD1_k127_3642501_1	1144312.PMI09_02611	5.571e-05	47.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
HFD1_k127_3646689_8	714083.JH370377_gene2052	2.934e-45	172.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4FKX9@85023|Microbacteriaceae	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD1_k127_3646689_2	234267.Acid_3458	4.665e-117	396.0	COG0601@1|root,COG0601@2|Bacteria,3Y437@57723|Acidobacteria	57723|Acidobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD1_k127_3646689_3	234267.Acid_3457	1.297e-107	360.0	COG1173@1|root,COG1173@2|Bacteria,3Y45P@57723|Acidobacteria	57723|Acidobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD1_k127_3646689_1	234267.Acid_3456	3.093e-207	659.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria	57723|Acidobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD1_k127_3646689_4	234267.Acid_3455	1.062e-83	286.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_3646689_0	234267.Acid_3454	0.0	1220.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y7SH@57723|Acidobacteria	57723|Acidobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD1_k127_3646689_6	234267.Acid_3452	1.361e-72	263.0	COG1404@1|root,COG1404@2|Bacteria,3Y97E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD1_k127_3646689_7	886293.Sinac_4604	3.956e-50	181.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HFD1_k127_3656482_3	234267.Acid_0894	1.906e-36	147.0	COG1567@1|root,COG1567@2|Bacteria,3Y72B@57723|Acidobacteria	57723|Acidobacteria	L	CRISPR-associated RAMP protein, Csm4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3656482_2	234267.Acid_0895	2.528e-212	664.0	COG1332@1|root,COG1332@2|Bacteria,3Y71E@57723|Acidobacteria	57723|Acidobacteria	L	RAMP superfamily	-	-	-	ko:K19140	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HFD1_k127_3656482_1	234267.Acid_1645	1.462e-259	805.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_3656482_0	234267.Acid_1646	0.0	1318.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HFD1_k127_3665835_1	861299.J421_1748	6.478e-91	309.0	2E4Q1@1|root,32ZIN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3665835_3	861299.J421_1563	5.184e-11	71.0	COG5550@1|root,COG5550@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3665835_0	1449049.JONW01000006_gene3265	7.293e-216	684.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2KF25@204458|Caulobacterales	204458|Caulobacterales	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_3665835_2	861299.J421_1753	5.004e-23	100.0	COG0446@1|root,COG4888@1|root,COG0446@2|Bacteria,COG4888@2|Bacteria	2|Bacteria	G	ASPIC UnbV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,Pyr_redox_2,UnbV_ASPIC,VCBS
HFD1_k127_3678258_14	234267.Acid_6050	2.374e-23	101.0	2DEJZ@1|root,2ZN9G@2|Bacteria,3Y8Y9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3678258_8	278963.ATWD01000002_gene215	5.869e-69	256.0	COG3275@1|root,COG3275@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	lytS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327	5TM-5TMR_LYT,ECF_trnsprt,GAF_3,HATPase_c,His_kinase
HFD1_k127_3678258_11	883126.HMPREF9710_04258	3.238e-45	180.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VQ5C@28216|Betaproteobacteria,476ME@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD1_k127_3678258_4	234267.Acid_0902	2.903e-157	500.0	COG0083@1|root,COG0083@2|Bacteria,3Y2ZV@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD1_k127_3678258_9	545695.TREAZ_0619	8.901e-57	204.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD1_k127_3678258_5	314345.SPV1_07676	3.624e-112	398.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_3678258_13	765420.OSCT_2097	2.329e-29	137.0	COG0745@1|root,COG2203@1|root,COG2267@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2267@2|Bacteria,2GAKU@200795|Chloroflexi,376PC@32061|Chloroflexia	32061|Chloroflexia	T	Pfam:DUF2305	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD1_k127_3678258_6	234267.Acid_1393	2.167e-96	319.0	COG1573@1|root,COG1573@2|Bacteria,3Y3Q7@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD1_k127_3678258_2	234267.Acid_1822	6.012e-223	698.0	COG0531@1|root,COG0531@2|Bacteria,3Y7AX@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_3678258_0	234267.Acid_2214	0.0	1090.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3678258_3	234267.Acid_1820	5.636e-179	573.0	COG2271@1|root,COG2271@2|Bacteria,3Y6PG@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_3678258_10	234267.Acid_1069	2.379e-56	215.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,3Y4VY@57723|Acidobacteria	57723|Acidobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
HFD1_k127_3678258_17	656024.FsymDg_2976	6.33e-07	58.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,2GMPZ@201174|Actinobacteria,4ESG4@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NHL,Pkinase
HFD1_k127_3678258_7	234267.Acid_7241	4.889e-90	306.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD1_k127_3678258_16	675635.Psed_6659	1.574e-12	79.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria,4EC1N@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
HFD1_k127_3678258_1	234267.Acid_7240	3.966e-269	834.0	COG0542@1|root,COG2204@1|root,COG0542@2|Bacteria,COG2204@2|Bacteria,3Y6T8@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small,Response_reg
HFD1_k127_3678258_12	234267.Acid_7239	5.176e-38	143.0	COG0361@1|root,COG0361@2|Bacteria,3Y8IP@57723|Acidobacteria	57723|Acidobacteria	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD1_k127_3694214_1	234267.Acid_5245	3.287e-288	910.0	COG0577@1|root,COG0577@2|Bacteria,3Y6IX@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3694214_0	234267.Acid_7183	0.0	1148.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3694214_2	234267.Acid_7183	1.141e-111	370.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3697185_7	234267.Acid_5627	3.4e-55	197.0	COG0662@1|root,COG0662@2|Bacteria,3Y8MJ@57723|Acidobacteria	57723|Acidobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3697185_1	234267.Acid_5626	2.372e-218	706.0	COG5549@1|root,COG5549@2|Bacteria	234267.Acid_5626|-	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3697185_0	234267.Acid_5624	3.166e-295	916.0	COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,3Y2X1@57723|Acidobacteria	57723|Acidobacteria	P	PFAM natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
HFD1_k127_3697185_2	234267.Acid_5908	7.512e-184	622.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CHASE,DUF3365,GAF_2,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_3697185_6	331869.BAL199_20949	4.987e-61	235.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,4BSDR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HFD1_k127_3697185_5	234267.Acid_1441	1.933e-89	320.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_3697185_3	234267.Acid_5909	8.941e-141	453.0	COG0483@1|root,COG0483@2|Bacteria,3Y3GD@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD1_k127_3697185_11	204669.Acid345_2059	1.117e-19	92.0	COG1923@1|root,COG1923@2|Bacteria,3Y5PK@57723|Acidobacteria,2JJYT@204432|Acidobacteriia	204432|Acidobacteriia	S	Hfq protein	-	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HFD1_k127_3697185_4	234267.Acid_5910	5.5e-110	365.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD1_k127_3697185_9	1382359.JIAL01000001_gene2419	1.37e-54	202.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria,2JMDU@204432|Acidobacteriia	204432|Acidobacteriia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD1_k127_3697185_10	234267.Acid_3933	1.154e-28	124.0	COG4219@1|root,COG4219@2|Bacteria,3Y9A7@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_3699017_0	234267.Acid_0066	3.07e-137	440.0	COG0313@1|root,COG0313@2|Bacteria,3Y32N@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD1_k127_3699017_1	234267.Acid_0403	9.404e-116	379.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
HFD1_k127_3699017_2	234267.Acid_0402	3.191e-64	237.0	COG3474@1|root,COG3474@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrom_CIII,Cytochrome_C7,GSDH
HFD1_k127_3699017_3	234267.Acid_0401	3.169e-31	124.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding,Peptidase_S8
HFD1_k127_3702272_5	234267.Acid_6196	6.245e-132	435.0	COG1629@1|root,COG4774@1|root,COG4771@2|Bacteria,COG4774@2|Bacteria,3Y3WR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3702272_14	1267535.KB906767_gene2345	1.003e-15	80.0	COG1629@1|root,COG4774@1|root,COG4771@2|Bacteria,COG4774@2|Bacteria,3Y3WR@57723|Acidobacteria,2JIZP@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3702272_10	485916.Dtox_4336	6.161e-39	153.0	2C82G@1|root,32RK9@2|Bacteria,1VZ8X@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD1_k127_3702272_13	631362.Thi970DRAFT_04585	6.384e-17	83.0	COG0639@1|root,COG0639@2|Bacteria,1RF21@1224|Proteobacteria,1S4CI@1236|Gammaproteobacteria,1WYEH@135613|Chromatiales	135613|Chromatiales	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HFD1_k127_3702272_16	1123373.ATXI01000001_gene467	0.0002362	49.0	COG1555@1|root,COG1555@2|Bacteria,2GI1F@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD1_k127_3702272_15	1267535.KB906767_gene1470	7.601e-10	66.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	gcd2	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_3702272_1	1340493.JNIF01000004_gene1047	3.18e-254	800.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
HFD1_k127_3702272_2	1340493.JNIF01000004_gene1048	1.962e-218	693.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_3702272_6	765912.Thimo_1124	5.334e-110	369.0	28IPJ@1|root,2Z8PI@2|Bacteria,1N3K3@1224|Proteobacteria,1S87S@1236|Gammaproteobacteria,1WYS7@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3702272_0	234267.Acid_7167	0.0	1315.0	COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria	57723|Acidobacteria	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
HFD1_k127_3702272_4	234267.Acid_2707	4.582e-194	615.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HFD1_k127_3702272_7	234267.Acid_2708	3.248e-102	337.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria	57723|Acidobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3702272_9	234267.Acid_2709	1.191e-66	239.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	damX	-	-	ko:K03112	-	-	-	-	ko00000	-	-	-	AAA_10,SPOR
HFD1_k127_3702272_3	234267.Acid_2710	3.198e-217	702.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,3Y2UJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,YfiO
HFD1_k127_3702272_12	1121121.KB894291_gene1369	4.304e-21	105.0	2DG92@1|root,2ZUZX@2|Bacteria,1UQR3@1239|Firmicutes,4HHNR@91061|Bacilli,26SZ8@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3702272_8	234267.Acid_0926	4.072e-71	242.0	COG1473@1|root,COG1473@2|Bacteria	2|Bacteria	S	N-acetyldiaminopimelate deacetylase activity	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_3708257_0	234267.Acid_0977	5.108e-154	496.0	COG0443@1|root,COG0443@2|Bacteria,3Y661@57723|Acidobacteria	57723|Acidobacteria	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HFD1_k127_3708257_3	234267.Acid_0976	2.089e-76	259.0	2CNUX@1|root,32SHU@2|Bacteria,3Y87T@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
HFD1_k127_3708257_1	234267.Acid_6291	1.02e-139	448.0	COG0457@1|root,COG0789@1|root,COG0457@2|Bacteria,COG0789@2|Bacteria,3Y3EM@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
HFD1_k127_3708257_4	234267.Acid_6292	1.37e-72	251.0	COG3127@1|root,COG3127@2|Bacteria,3Y7ZT@57723|Acidobacteria	57723|Acidobacteria	Q	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3708257_6	1267535.KB906767_gene2392	3.118e-43	160.0	COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria	57723|Acidobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
HFD1_k127_3708257_2	234267.Acid_6294	1.126e-105	347.0	COG0020@1|root,COG0020@2|Bacteria,3Y4GH@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD1_k127_3708257_5	234267.Acid_0743	1.082e-51	186.0	COG0304@1|root,COG0304@2|Bacteria,3Y2NT@57723|Acidobacteria	57723|Acidobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD1_k127_3708257_8	251221.35211908	5.164e-38	156.0	COG1621@1|root,COG3191@1|root,COG1621@2|Bacteria,COG3191@2|Bacteria,1GR11@1117|Cyanobacteria	2|Bacteria	EQ	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,DUF608,Glyco_hydr_116N,VCBS
HFD1_k127_3708257_7	234267.Acid_0743	1.586e-39	148.0	COG0304@1|root,COG0304@2|Bacteria,3Y2NT@57723|Acidobacteria	57723|Acidobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD1_k127_3712956_1	278963.ATWD01000001_gene1755	6.344e-96	323.0	COG0609@1|root,COG0609@2|Bacteria,3Y7KJ@57723|Acidobacteria	57723|Acidobacteria	P	FecCD transport family	-	-	-	-	-	-	-	-	-	-	-	-	FecCD
HFD1_k127_3712956_4	290397.Adeh_3466	1.362e-52	208.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2Z33X@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD1_k127_3712956_2	1340493.JNIF01000003_gene4442	2.424e-83	296.0	COG0614@1|root,COG0614@2|Bacteria,3Y7Z8@57723|Acidobacteria	57723|Acidobacteria	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HFD1_k127_3712956_3	589865.DaAHT2_1591	5.493e-54	208.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NV6@68525|delta/epsilon subdivisions,2WIPB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	cobD	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0487	Aminotran_1_2
HFD1_k127_3712956_0	1340493.JNIF01000003_gene4440	1.731e-97	330.0	COG1270@1|root,COG1270@2|Bacteria,3Y76N@57723|Acidobacteria	57723|Acidobacteria	H	CobD/Cbib protein	-	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HFD1_k127_3712956_5	1340493.JNIF01000003_gene4439	1.091e-49	183.0	COG1492@1|root,COG1492@2|Bacteria,3Y64K@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HFD1_k127_3727371_2	234267.Acid_6980	7.304e-66	226.0	COG0329@1|root,COG0329@2|Bacteria,3Y3V8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD1_k127_3727371_1	234267.Acid_6981	5.211e-106	349.0	COG0289@1|root,COG0289@2|Bacteria,3Y50R@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DapB family	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HFD1_k127_3727371_0	234267.Acid_6982	5.348e-196	615.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
HFD1_k127_3743439_1	234267.Acid_6104	2.686e-70	244.0	COG4632@1|root,COG4632@2|Bacteria,3Y8TM@57723|Acidobacteria	57723|Acidobacteria	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HFD1_k127_3743439_0	234267.Acid_2814	2.225e-307	970.0	COG0577@1|root,COG0577@2|Bacteria,3Y3V2@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3743439_2	234267.Acid_3085	9.678e-32	130.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	pelC	-	2.1.1.72	ko:K03765,ko:K07277,ko:K07316,ko:K21008	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko02000,ko02048,ko03000,ko03029	1.B.33	-	-	VCBS
HFD1_k127_3746004_1	234267.Acid_1019	8.196e-120	387.0	COG1089@1|root,COG1089@2|Bacteria,3Y3QZ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD1_k127_3746004_0	234267.Acid_1018	2.992e-280	864.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria	57723|Acidobacteria	H	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	CoaE,PmbA_TldD
HFD1_k127_3746004_5	234267.Acid_1018	0.0005303	44.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria	57723|Acidobacteria	H	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	CoaE,PmbA_TldD
HFD1_k127_3746004_4	1380350.JIAP01000002_gene4396	5.849e-20	93.0	COG3077@1|root,COG3077@2|Bacteria,1N73E@1224|Proteobacteria,2TVSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
HFD1_k127_3746004_3	658187.LDG_5791	1.137e-34	134.0	COG3041@1|root,COG3041@2|Bacteria,1N9NX@1224|Proteobacteria,1SCBQ@1236|Gammaproteobacteria,1JFD5@118969|Legionellales	118969|Legionellales	S	Bacterial toxin of type II toxin-antitoxin system, YafQ	-	-	-	-	-	-	-	-	-	-	-	-	YafQ_toxin
HFD1_k127_3746004_2	1267535.KB906767_gene42	5.81e-49	188.0	28MCN@1|root,2ZAQR@2|Bacteria,3Y8K1@57723|Acidobacteria,2JNFU@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3760355_1	234267.Acid_0139	2.053e-65	231.0	COG3485@1|root,COG3485@2|Bacteria	234267.Acid_0139|-	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3760355_0	234267.Acid_6345	4.309e-150	479.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD1_k127_3760355_2	1120953.AUBH01000001_gene715	1.311e-17	96.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,1S7K0@1236|Gammaproteobacteria,46AUR@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HFD1_k127_376117_3	234267.Acid_1490	4.44e-47	171.0	COG3276@1|root,COG3276@2|Bacteria,3Y6R2@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HFD1_k127_376117_2	886293.Sinac_7451	8.854e-56	221.0	2EU85@1|root,33MQK@2|Bacteria,2J4RA@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_376117_4	65393.PCC7424_3722	6.561e-15	83.0	COG0563@1|root,COG0563@2|Bacteria,1G50C@1117|Cyanobacteria,3KHNM@43988|Cyanothece	1117|Cyanobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.adk	ADK
HFD1_k127_376117_0	521674.Plim_0517	0.0	1036.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_376117_1	521674.Plim_0518	1.72e-142	460.0	COG4102@1|root,COG4102@2|Bacteria,2J4YY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_3778411_1	234267.Acid_0130	2.428e-99	328.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_3778411_4	234267.Acid_0129	3.99e-51	185.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_0129|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3778411_2	234267.Acid_0128	2.844e-89	298.0	COG0634@1|root,COG0634@2|Bacteria,3Y2FD@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HFD1_k127_3778411_0	234267.Acid_0127	4.335e-162	514.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
HFD1_k127_3778411_3	234267.Acid_0123	1.886e-85	289.0	COG2096@1|root,COG2096@2|Bacteria,3Y77H@57723|Acidobacteria	57723|Acidobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HFD1_k127_3778411_5	1173023.KE650771_gene655	8.071e-28	128.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G5VM@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
HFD1_k127_3792412_4	234267.Acid_4844	3.465e-172	546.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HFD1_k127_3792412_1	234267.Acid_1966	1.798e-289	930.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3792412_11	671143.DAMO_0845	1.467e-11	69.0	2EUJ6@1|root,33N15@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3792412_6	1267535.KB906767_gene3053	1.749e-57	226.0	COG4995@1|root,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD1_k127_3792412_8	1267535.KB906767_gene3052	1.97e-39	153.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Y7@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3792412_14	194439.CT1376	5.703e-06	54.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1FEYU@1090|Chlorobi	1090|Chlorobi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_3792412_15	1382359.JIAL01000001_gene1120	0.0002984	50.0	COG5343@1|root,COG5343@2|Bacteria,3Y4J0@57723|Acidobacteria,2JJAC@204432|Acidobacteriia	204432|Acidobacteriia	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD1_k127_3792412_10	234267.Acid_7128	4.447e-31	130.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	57723|Acidobacteria	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3792412_7	234267.Acid_6464	4.796e-44	176.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_6464|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3792412_9	1210884.HG799469_gene13983	1.383e-32	136.0	COG1994@1|root,COG1994@2|Bacteria,2J0CK@203682|Planctomycetes	203682|Planctomycetes	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD1_k127_3792412_0	861299.J421_0317	3.606e-317	992.0	28JZZ@1|root,2Z9PZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3792412_5	1128421.JAGA01000003_gene3455	6.301e-60	228.0	COG1832@1|root,COG1832@2|Bacteria,2NRIH@2323|unclassified Bacteria	2|Bacteria	S	CoA binding domain	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD1_k127_3792412_2	1128421.JAGA01000003_gene3456	1.24e-232	725.0	COG2873@1|root,COG2873@2|Bacteria,2NQN4@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	cysD	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD1_k127_3792412_3	234267.Acid_5325	3.583e-231	723.0	COG0673@1|root,COG0673@2|Bacteria,3Y7B1@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_3792412_12	234267.Acid_7475	2.142e-10	63.0	COG3119@1|root,COG3119@2|Bacteria,3Y7FV@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF229)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_3806386_4	682795.AciX8_2534	7.406e-26	111.0	COG4219@1|root,COG4219@2|Bacteria,3Y7YX@57723|Acidobacteria,2JMZ3@204432|Acidobacteriia	204432|Acidobacteriia	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_3806386_0	234267.Acid_3470	2.251e-211	683.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_3806386_3	234267.Acid_0365	4.15e-32	130.0	2957Q@1|root,2ZSK6@2|Bacteria,3Y95H@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3806386_2	234267.Acid_2255	2.994e-130	422.0	COG3618@1|root,COG3618@2|Bacteria,3Y4FF@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_3806386_1	234267.Acid_6157	1.151e-185	587.0	COG2355@1|root,COG2355@2|Bacteria,3Y3RS@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_3815502_2	1278309.KB907099_gene2913	2.258e-40	170.0	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3815502_0	1278309.KB907099_gene2912	6.279e-134	439.0	COG2132@1|root,COG2132@2|Bacteria,1R89G@1224|Proteobacteria,1S5X0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_3
HFD1_k127_3815502_1	1123518.ARWI01000001_gene1640	7.56e-59	220.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HFD1_k127_3853493_6	1293054.HSACCH_02642	1.495e-35	148.0	COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,249FE@186801|Clostridia,3WBVU@53433|Halanaerobiales	186801|Clostridia	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
HFD1_k127_3853493_3	743719.PaelaDRAFT_4077	1.447e-135	447.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,1UWBV@1239|Firmicutes,4I2E0@91061|Bacilli,26W7A@186822|Paenibacillaceae	91061|Bacilli	M	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,F5_F8_type_C
HFD1_k127_3853493_2	234267.Acid_2264	1.013e-181	582.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
HFD1_k127_3853493_0	234267.Acid_2265	8.144e-219	694.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_3853493_1	234267.Acid_2266	7.857e-185	620.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,WD40
HFD1_k127_3853493_5	1340493.JNIF01000003_gene2233	1.848e-52	190.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_3853493_4	1267533.KB906738_gene2186	1.302e-56	210.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
HFD1_k127_3853839_6	748247.AZKH_0907	6.465e-48	186.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_3853839_1	760192.Halhy_2892	5.71e-130	451.0	COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,1IR5W@117747|Sphingobacteriia	976|Bacteroidetes	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD1_k127_3853839_3	314232.SKA53_01024	7.369e-78	281.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD1_k127_3853839_7	743719.PaelaDRAFT_5505	1.787e-29	123.0	COG0707@1|root,COG0707@2|Bacteria,1V91X@1239|Firmicutes,4IPX3@91061|Bacilli	91061|Bacilli	M	Oligosaccharide biosynthesis protein Alg14 like	-	-	-	-	-	-	-	-	-	-	-	-	Alg14
HFD1_k127_3853839_9	324831.LGAS_1151	2.503e-17	88.0	COG5017@1|root,COG5017@2|Bacteria,1VCGX@1239|Firmicutes,4HMKJ@91061|Bacilli,3F5WF@33958|Lactobacillaceae	91061|Bacilli	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
HFD1_k127_3853839_0	1123368.AUIS01000027_gene1355	2.729e-182	595.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD1_k127_3853839_4	404589.Anae109_4434	4.948e-73	260.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,43085@68525|delta/epsilon subdivisions,2WVFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
HFD1_k127_3853839_2	234267.Acid_4658	1.654e-117	394.0	COG0472@1|root,COG0472@2|Bacteria,3Y5GB@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HFD1_k127_3853839_8	1205680.CAKO01000040_gene818	3.077e-25	116.0	COG2242@1|root,COG2242@2|Bacteria,1QX6B@1224|Proteobacteria,2TZAR@28211|Alphaproteobacteria,2JUEP@204441|Rhodospirillales	204441|Rhodospirillales	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD1_k127_3853839_5	395493.BegalDRAFT_2283	1.173e-52	199.0	COG4641@1|root,COG4641@2|Bacteria,1R4AN@1224|Proteobacteria,1SGDZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2
HFD1_k127_385389_2	234267.Acid_3167	2.303e-25	105.0	COG0353@1|root,COG0353@2|Bacteria,3Y31E@57723|Acidobacteria	57723|Acidobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HFD1_k127_385389_1	234267.Acid_3166	4.965e-44	168.0	COG0718@1|root,COG0718@2|Bacteria,3Y5CB@57723|Acidobacteria	57723|Acidobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HFD1_k127_385389_0	234267.Acid_3165	5.516e-234	736.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C4@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HFD1_k127_3864574_0	552811.Dehly_0076	5.149e-115	382.0	COG3039@1|root,COG3039@2|Bacteria,2G9US@200795|Chloroflexi,34D8F@301297|Dehalococcoidia	2|Bacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HFD1_k127_3866450_1	234267.Acid_7276	3.036e-147	473.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria	2|Bacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_3866450_0	234267.Acid_7277	2.741e-150	481.0	COG1087@1|root,COG1087@2|Bacteria,3Y3FK@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_3866450_2	234267.Acid_0191	3.877e-14	74.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	phlE	-	-	ko:K02511,ko:K02575,ko:K13021	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.14.3,2.A.1.14.9,2.A.1.8	-	-	MFS_1,Sugar_tr
HFD1_k127_3867842_2	1340493.JNIF01000003_gene4018	4.085e-105	349.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH
HFD1_k127_3867842_8	1038858.AXBA01000015_gene2109	2.137e-23	105.0	29BEN@1|root,2ZYD0@2|Bacteria,1RG57@1224|Proteobacteria,2U82D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function with HXXEE motif	-	-	-	-	-	-	-	-	-	-	-	-	HXXEE
HFD1_k127_3867842_10	29875.EHK18442	1.501e-06	59.0	29BEN@1|root,2SVXY@2759|Eukaryota,38SFM@33154|Opisthokonta,3PU6R@4751|Fungi,3RDHY@4890|Ascomycota,21HSM@147550|Sordariomycetes,3TNXN@5125|Hypocreales,3U097@5129|Hypocreaceae	4751|Fungi	S	Protein of unknown function with HXXEE motif	-	-	-	-	-	-	-	-	-	-	-	-	HXXEE
HFD1_k127_3867842_1	1267535.KB906767_gene3810	1.35e-187	601.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3810|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3867842_0	234267.Acid_6337	0.0	1081.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria	57723|Acidobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD1_k127_3867842_7	234267.Acid_0106	1.389e-56	205.0	COG2172@1|root,COG2172@2|Bacteria,3Y4TY@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD1_k127_3867842_6	234267.Acid_0107	7.852e-58	203.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria	57723|Acidobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD1_k127_3867842_9	234267.Acid_0108	1.035e-19	99.0	COG2104@1|root,COG2104@2|Bacteria,3Y90M@57723|Acidobacteria	57723|Acidobacteria	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD1_k127_3867842_5	234267.Acid_0109	9.454e-59	205.0	COG0838@1|root,COG0838@2|Bacteria,3Y5CV@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD1_k127_3867842_3	234267.Acid_0110	5.608e-84	281.0	COG0852@1|root,COG0852@2|Bacteria,3Y4IQ@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD1_k127_3867842_4	234267.Acid_0111	1.671e-75	255.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
HFD1_k127_3868890_0	1267535.KB906767_gene2855	6.49e-179	574.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat,TonB_dep_Rec
HFD1_k127_3868890_3	1173025.GEI7407_0339	1.838e-28	131.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD1_k127_3868890_1	335543.Sfum_1617	3.048e-142	477.0	COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD1_k127_3868890_2	234267.Acid_0796	3.389e-100	327.0	COG0568@1|root,COG0568@2|Bacteria,3Y6Z7@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 3	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD1_k127_387726_1	1267535.KB906767_gene3553	5.735e-163	517.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria,2JHR1@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HFD1_k127_387726_2	234267.Acid_3377	1.036e-160	509.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria	57723|Acidobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HFD1_k127_387726_10	234267.Acid_3376	7.339e-66	241.0	COG0105@1|root,COG0105@2|Bacteria,3Y4MW@57723|Acidobacteria	57723|Acidobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HFD1_k127_387726_8	1267535.KB906767_gene3001	2.313e-73	252.0	COG4993@1|root,COG4993@2|Bacteria,3Y6CA@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_387726_6	234267.Acid_3211	1.943e-112	368.0	COG0327@1|root,COG0327@2|Bacteria,3Y65N@57723|Acidobacteria	57723|Acidobacteria	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HFD1_k127_387726_5	234267.Acid_3210	1.964e-115	379.0	COG0327@1|root,COG0327@2|Bacteria,3Y6HX@57723|Acidobacteria	57723|Acidobacteria	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HFD1_k127_387726_19	1173028.ANKO01000197_gene6087	7.587e-12	74.0	COG0454@1|root,COG0456@2|Bacteria,1GEIS@1117|Cyanobacteria	1117|Cyanobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_387726_22	56107.Cylst_1420	5.876e-05	49.0	COG0454@1|root,COG0456@2|Bacteria,1GEIS@1117|Cyanobacteria	1117|Cyanobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_387726_0	234267.Acid_1641	8.123e-173	549.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD1_k127_387726_4	861299.J421_0393	3.022e-132	454.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0393|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_387726_16	1267533.KB906733_gene2992	2.829e-32	128.0	COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_387726_20	596152.DesU5LDRAFT_2493	1.357e-10	70.0	2DPHF@1|root,33237@2|Bacteria,1R4GY@1224|Proteobacteria,435JT@68525|delta/epsilon subdivisions,2WZY2@28221|Deltaproteobacteria,2M8FU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
HFD1_k127_387726_7	1158294.JOMI01000003_gene2066	7.736e-82	293.0	COG0535@1|root,COG0535@2|Bacteria,4PA9R@976|Bacteroidetes,2FWDR@200643|Bacteroidia	976|Bacteroidetes	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HFD1_k127_387726_3	234267.Acid_3282	8.01e-146	469.0	COG1082@1|root,COG1082@2|Bacteria,3Y688@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_387726_13	861299.J421_0074	8.271e-55	205.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD1_k127_387726_12	204669.Acid345_0070	5.773e-56	211.0	COG1835@1|root,COG1835@2|Bacteria,3Y524@57723|Acidobacteria,2JJEN@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD1_k127_387726_11	234267.Acid_2793	1.762e-61	224.0	COG2197@1|root,COG2197@2|Bacteria,3Y7QM@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_387726_9	234267.Acid_2792	9.793e-72	271.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
HFD1_k127_387726_18	1267535.KB906767_gene1333	1.512e-13	77.0	COG0745@1|root,COG0745@2|Bacteria,3Y8Y3@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_387726_21	1210884.HG799465_gene11608	4.17e-10	65.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_387726_17	756272.Plabr_3627	1.1e-27	115.0	COG2133@1|root,COG2133@2|Bacteria,2IZH6@203682|Planctomycetes	203682|Planctomycetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_387726_14	234267.Acid_3137	1.745e-39	153.0	COG4219@1|root,COG4219@2|Bacteria,3Y35Z@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_3881177_0	1267535.KB906767_gene1889	0.0	1245.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia	204432|Acidobacteriia	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HFD1_k127_3881177_3	1267535.KB906767_gene603	4.941e-53	193.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_3881177_2	1267535.KB906767_gene903	1.332e-226	721.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria,2JHSP@204432|Acidobacteriia	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA2	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SecA_DEAD,SecA_PP_bind,SecA_SW
HFD1_k127_3881177_1	234267.Acid_3518	0.0	1029.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD1_k127_3882699_1	1340493.JNIF01000003_gene2040	4.818e-13	70.0	COG1917@1|root,COG1917@2|Bacteria,3Y8X8@57723|Acidobacteria	57723|Acidobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding
HFD1_k127_3882699_0	251221.35211765	1.24e-94	323.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_3883586_0	234267.Acid_6585	0.0	1035.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_3883586_18	926566.Terro_0115	5.534e-32	130.0	COG1555@1|root,COG1555@2|Bacteria,3Y869@57723|Acidobacteria	57723|Acidobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD1_k127_3883586_14	234267.Acid_6134	1.552e-56	209.0	COG2010@1|root,COG2010@2|Bacteria,3Y6RF@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_3883586_2	234267.Acid_6133	6.699e-208	660.0	COG4993@1|root,COG4993@2|Bacteria,3Y6HR@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_3883586_23	107635.AZUO01000001_gene1760	0.0008115	50.0	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2TTH6@28211|Alphaproteobacteria,36XTV@31993|Methylocystaceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase,NHL
HFD1_k127_3883586_16	484770.UFO1_3373	1e-35	138.0	COG1917@1|root,COG1917@2|Bacteria,1V8SS@1239|Firmicutes,4H7RN@909932|Negativicutes	909932|Negativicutes	S	Ethanolamine utilisation protein EutQ	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_3883586_15	479434.Sthe_0226	1.527e-41	160.0	COG3153@1|root,COG3153@2|Bacteria,2G7B4@200795|Chloroflexi	200795|Chloroflexi	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_9
HFD1_k127_3883586_13	234267.Acid_6968	7.96e-58	208.0	COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria	57723|Acidobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HFD1_k127_3883586_6	935948.KE386494_gene961	6.7e-132	444.0	arCOG03330@1|root,2Z82Q@2|Bacteria,1U584@1239|Firmicutes,24B07@186801|Clostridia,42FIS@68295|Thermoanaerobacterales	186801|Clostridia	H	Methanol-cobalamin methyltransferase B subunit	-	-	2.1.1.90	ko:K04480	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R04384,R09098	RC00035,RC01144,RC01145,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	MtaB
HFD1_k127_3883586_17	234267.Acid_4348	3.199e-35	147.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_3883586_8	483219.LILAB_27660	6.449e-94	310.0	COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,42Z2R@68525|delta/epsilon subdivisions,2WUGF@28221|Deltaproteobacteria,2Z37Y@29|Myxococcales	28221|Deltaproteobacteria	S	Maltose acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Mac
HFD1_k127_3883586_11	1121904.ARBP01000012_gene1301	6.795e-81	300.0	2DBK2@1|root,2Z9Q1@2|Bacteria,4NET4@976|Bacteroidetes,47MUQ@768503|Cytophagia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3883586_9	1340493.JNIF01000004_gene17	9.85e-93	336.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_3883586_12	483219.LILAB_18865	7.243e-78	273.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
HFD1_k127_3883586_3	1267535.KB906767_gene2241	4.961e-203	639.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria,2JIEP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD1_k127_3883586_10	234267.Acid_6705	8.326e-89	298.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria	57723|Acidobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HFD1_k127_3883586_4	234267.Acid_6707	7.977e-200	633.0	COG0162@1|root,COG0162@2|Bacteria,3Y2NC@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HFD1_k127_3883586_20	1121904.ARBP01000001_gene5476	4.398e-15	85.0	COG4122@1|root,COG4122@2|Bacteria,4NH42@976|Bacteroidetes,47KAK@768503|Cytophagia	976|Bacteroidetes	S	PFAM O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HFD1_k127_3883586_5	234267.Acid_1210	3.501e-152	503.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amino_oxidase,Ank,Ank_2,Ank_3,Ank_4,Ank_5,PSCyt1,Peptidase_C14,Prenyltrans,SQHop_cyclase_C
HFD1_k127_3883586_1	1340493.JNIF01000004_gene235	4.658e-305	970.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_3902561_0	591158.SSMG_07037	9.084e-90	308.0	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria	201174|Actinobacteria	E	Dipeptidase	Dpep	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_3902561_1	234267.Acid_0627	1.949e-06	58.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHU_C,Cadherin-like,ChW,F5_F8_type_C,fn3
HFD1_k127_3906596_0	682795.AciX8_1275	9.571e-34	150.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_9
HFD1_k127_3914941_0	234267.Acid_1435	1.22e-153	493.0	COG5621@1|root,COG5621@2|Bacteria	2|Bacteria	S	spheroidene biosynthetic process	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HFD1_k127_3914941_1	1267535.KB906767_gene1063	3.205e-52	187.0	COG3684@1|root,COG3684@2|Bacteria,3Y33H@57723|Acidobacteria,2JIH2@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD1_k127_3921063_2	234267.Acid_4748	2.103e-65	238.0	COG1858@1|root,COG1858@2|Bacteria,3Y7FY@57723|Acidobacteria	57723|Acidobacteria	P	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HFD1_k127_3921063_5	1108045.GORHZ_062_00290	4.087e-13	75.0	COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria,4GA7D@85026|Gordoniaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD1_k127_3921063_0	1267534.KB906754_gene3093	6.396e-172	549.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_3921063_1	278963.ATWD01000001_gene2469	2.102e-112	370.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_3921063_4	234267.Acid_3528	2.846e-42	158.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD1_k127_3921063_3	234267.Acid_3528	3.981e-63	223.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD1_k127_392885_3	909663.KI867150_gene971	6.808e-125	408.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_392885_1	697281.Mahau_1189	8.13e-165	553.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,42EMX@68295|Thermoanaerobacterales	186801|Clostridia	G	alpha-L-rhamnosidase domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
HFD1_k127_392885_2	994573.T472_0218860	1.865e-138	456.0	COG3408@1|root,COG3408@2|Bacteria,1UNFF@1239|Firmicutes,25H1X@186801|Clostridia,36PH0@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
HFD1_k127_392885_4	333138.LQ50_02240	1.151e-114	402.0	COG4030@1|root,COG4030@2|Bacteria,1UZEG@1239|Firmicutes,4IT9G@91061|Bacilli,1ZM4C@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
HFD1_k127_392885_5	344747.PM8797T_15706	6.681e-105	357.0	COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_392885_0	204669.Acid345_0639	4.224e-201	640.0	COG1482@1|root,COG1482@2|Bacteria,3Y71X@57723|Acidobacteria,2JK7C@204432|Acidobacteriia	204432|Acidobacteriia	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_392885_6	82995.CR62_08785	1.268e-74	264.0	COG2140@1|root,COG2140@2|Bacteria,1NKQJ@1224|Proteobacteria,1RTEZ@1236|Gammaproteobacteria,402G7@613|Serratia	1236|Gammaproteobacteria	G	Glucose-6-phosphate isomerase (GPI)	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
HFD1_k127_3944502_4	234267.Acid_2564	1.068e-33	141.0	2DTVW@1|root,33MW2@2|Bacteria,3Y606@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3944502_0	234267.Acid_2565	4.342e-115	377.0	COG0164@1|root,COG0164@2|Bacteria,3Y49K@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HFD1_k127_3944502_3	234267.Acid_2566	4.66e-58	203.0	COG0335@1|root,COG0335@2|Bacteria,3Y4P6@57723|Acidobacteria	57723|Acidobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HFD1_k127_3944502_1	234267.Acid_5927	3.459e-97	340.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_3944502_2	1122603.ATVI01000006_gene83	2.897e-68	244.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL,VCBS
HFD1_k127_3945453_6	234267.Acid_0020	9.18e-119	389.0	COG0457@1|root,COG0457@2|Bacteria,3Y6VN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3945453_0	234267.Acid_1591	0.0	1602.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_3945453_1	234267.Acid_3227	1.92e-287	890.0	COG2857@1|root,COG2857@2|Bacteria	2|Bacteria	C	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3945453_3	234267.Acid_7941	6.923e-190	604.0	COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HFD1_k127_3945453_8	234267.Acid_7940	3.817e-62	218.0	COG1595@1|root,COG1595@2|Bacteria,3Y5K8@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_3945453_10	1267535.KB906767_gene4943	2.267e-14	82.0	291QZ@1|root,2ZPB0@2|Bacteria,3Y92F@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3945453_4	234267.Acid_7937	9.598e-137	445.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_3945453_2	234267.Acid_7936	1.146e-213	673.0	COG1566@1|root,COG1566@2|Bacteria,3Y9B7@57723|Acidobacteria	57723|Acidobacteria	V	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD1_k127_3945453_5	234267.Acid_7935	1.26e-133	432.0	COG0825@1|root,COG0825@2|Bacteria,3Y34D@57723|Acidobacteria	57723|Acidobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HFD1_k127_3945453_7	234267.Acid_7932	2.408e-85	286.0	COG0613@1|root,COG0613@2|Bacteria,3Y5C1@57723|Acidobacteria	57723|Acidobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HFD1_k127_3980008_1	234267.Acid_2364	6.802e-112	367.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_3980008_0	234267.Acid_2365	0.0	2136.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD1_k127_4015753_1	234267.Acid_0030	1.959e-312	969.0	COG1074@1|root,COG1074@2|Bacteria,3Y41J@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD1_k127_4015753_5	290397.Adeh_2899	1.617e-31	142.0	COG0823@1|root,COG0823@2|Bacteria,1NKG5@1224|Proteobacteria	1224|Proteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_4015753_0	234267.Acid_0029	0.0	1176.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	addB	-	3.6.4.12,5.99.1.2	ko:K03169,ko:K16899	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PDDEXK_1
HFD1_k127_4015753_2	234267.Acid_2542	4.681e-114	379.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_4015753_4	234267.Acid_3654	5.847e-46	173.0	COG1028@1|root,COG1028@2|Bacteria,3Y822@57723|Acidobacteria	57723|Acidobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_4015753_6	234267.Acid_1737	8.603e-13	70.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4015753_3	234267.Acid_6495	1.777e-97	339.0	COG0577@1|root,COG0577@2|Bacteria,3Y6H1@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4020303_1	234267.Acid_5120	3.617e-97	318.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD1_k127_4020303_0	234267.Acid_5121	0.0	1229.0	COG0480@1|root,COG0480@2|Bacteria,3Y2YX@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD1_k127_4020303_3	234267.Acid_5122	3.284e-86	286.0	COG0049@1|root,COG0049@2|Bacteria,3Y3FF@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD1_k127_4020303_4	234267.Acid_5123	4.484e-75	256.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria	57723|Acidobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD1_k127_4020303_2	234267.Acid_5140	4.102e-95	318.0	28IJE@1|root,2Z8KB@2|Bacteria,3Y46I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4020303_6	314230.DSM3645_07935	7.244e-19	91.0	2DRI2@1|root,33BVT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4020303_5	234267.Acid_1649	9.655e-38	141.0	COG0489@1|root,COG0489@2|Bacteria,3Y66Z@57723|Acidobacteria	57723|Acidobacteria	D	AAA domain	-	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD1_k127_4026531_12	234267.Acid_5279	1.02e-110	362.0	COG0363@1|root,COG0363@2|Bacteria,3Y430@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD1_k127_4026531_16	234267.Acid_5280	2.1e-101	366.0	COG3429@1|root,COG3429@2|Bacteria,3Y7S9@57723|Acidobacteria	57723|Acidobacteria	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HFD1_k127_4026531_1	234267.Acid_5281	3.219e-280	869.0	COG0364@1|root,COG0364@2|Bacteria,3Y2JZ@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD1_k127_4026531_6	234267.Acid_6499	1.815e-195	625.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD1_k127_4026531_2	234267.Acid_4952	9.384e-277	863.0	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD1_k127_4026531_7	234267.Acid_1749	1.817e-175	562.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,3Y652@57723|Acidobacteria	57723|Acidobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4026531_10	234267.Acid_5602	1.282e-130	443.0	COG0598@1|root,COG0598@2|Bacteria,3Y4BT@57723|Acidobacteria	57723|Acidobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD1_k127_4026531_21	330084.JNYZ01000010_gene6755	1.248e-22	109.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_4026531_14	234267.Acid_4707	1.586e-107	355.0	COG0697@1|root,COG0697@2|Bacteria,3Y570@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_4026531_22	1380390.JIAT01000010_gene3840	1.722e-22	106.0	COG3920@1|root,COG5002@1|root,COG3920@2|Bacteria,COG5002@2|Bacteria,2HFEI@201174|Actinobacteria,4CTJF@84995|Rubrobacteria	84995|Rubrobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
HFD1_k127_4026531_17	1089553.Tph_c09100	8.06e-98	338.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,42G9W@68295|Thermoanaerobacterales	186801|Clostridia	H	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HFD1_k127_4026531_13	595460.RRSWK_04700	2.474e-108	364.0	COG0673@1|root,COG0673@2|Bacteria,2IXRR@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_4026531_23	1286632.P278_00050	4.923e-19	94.0	COG1082@1|root,COG1082@2|Bacteria,4NFKF@976|Bacteroidetes,1HZU8@117743|Flavobacteriia	976|Bacteroidetes	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_4026531_18	1122919.KB905568_gene2840	8.364e-82	282.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H9W0@91061|Bacilli,26SKE@186822|Paenibacillaceae	91061|Bacilli	G	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
HFD1_k127_4026531_3	234267.Acid_1231	9.454e-266	826.0	COG1069@1|root,COG1069@2|Bacteria,3Y3B6@57723|Acidobacteria	57723|Acidobacteria	C	PFAM carbohydrate kinase	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
HFD1_k127_4026531_4	1267535.KB906767_gene2163	2.042e-233	730.0	COG2407@1|root,COG2407@2|Bacteria,3Y2FH@57723|Acidobacteria,2JI15@204432|Acidobacteriia	204432|Acidobacteriia	G	L-fucose isomerase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
HFD1_k127_4026531_8	234267.Acid_1234	4.358e-173	547.0	COG1609@1|root,COG1609@2|Bacteria,3Y49N@57723|Acidobacteria	57723|Acidobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD1_k127_4026531_19	234267.Acid_2599	1.024e-74	253.0	COG2131@1|root,COG2131@2|Bacteria	2|Bacteria	F	dCMP deaminase activity	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HFD1_k127_4026531_0	234267.Acid_6523	0.0	1031.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y6FN@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_4026531_5	234267.Acid_4241	1.07e-221	702.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_4026531_11	234267.Acid_6159	7.734e-123	404.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_4026531_15	1267534.KB906757_gene845	8.944e-105	348.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD1_k127_4026531_9	1267535.KB906767_gene3668	7.546e-134	445.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_4026531_20	215803.DB30_4205	4.742e-25	106.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,42P9U@68525|delta/epsilon subdivisions,2WUQE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HFD1_k127_4027755_0	234267.Acid_4105	5.038e-243	758.0	COG0367@1|root,COG0367@2|Bacteria,3Y6CC@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD1_k127_4027755_3	234267.Acid_4106	1.089e-33	132.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_4027755_1	234267.Acid_4106	2.421e-232	726.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_4027755_2	234267.Acid_4108	1.331e-185	593.0	COG1783@1|root,COG1783@2|Bacteria,3Y64R@57723|Acidobacteria	57723|Acidobacteria	S	phage Terminase large subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4031621_4	530564.Psta_3944	6.455e-90	308.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_4031621_6	1047013.AQSP01000125_gene2637	3.996e-52	203.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
HFD1_k127_4031621_3	1089551.KE386572_gene989	3.084e-92	316.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,4BP6M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HFD1_k127_4031621_8	690850.Desaf_2037	6.195e-21	97.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2M7Z5@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Cache_3-Cache_2,HAMP,SpoIIE,dCache_1,dCache_2
HFD1_k127_4031621_7	309801.trd_A0076	2.174e-33	136.0	COG1878@1|root,COG1878@2|Bacteria,2G6VY@200795|Chloroflexi	200795|Chloroflexi	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_4031621_10	309801.trd_A0076	2.59e-05	51.0	COG1878@1|root,COG1878@2|Bacteria,2G6VY@200795|Chloroflexi	200795|Chloroflexi	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_4031621_11	583355.Caka_2937	0.0005285	46.0	COG3828@1|root,COG3828@2|Bacteria,46V1D@74201|Verrucomicrobia,3KA32@414999|Opitutae	74201|Verrucomicrobia	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HFD1_k127_4031621_1	1173028.ANKO01000041_gene3210	1.184e-217	691.0	COG1012@1|root,COG1012@2|Bacteria,1G09W@1117|Cyanobacteria,1H90R@1150|Oscillatoriales	1117|Cyanobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_4031621_0	234267.Acid_1966	0.0	1638.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_4031621_5	509635.N824_24210	3.274e-59	235.0	COG0463@1|root,COG4122@1|root,COG0463@2|Bacteria,COG4122@2|Bacteria,4NX3Y@976|Bacteroidetes,1IVNM@117747|Sphingobacteriia	976|Bacteroidetes	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_24
HFD1_k127_4031621_2	398580.Dshi_2548	3.264e-147	509.0	COG1555@1|root,COG1555@2|Bacteria,1QWR7@1224|Proteobacteria	1224|Proteobacteria	L	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
HFD1_k127_4033071_0	234267.Acid_2397	6.61e-105	347.0	COG0500@1|root,COG2226@2|Bacteria,3Y7RY@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_4033071_2	234267.Acid_5150	1.688e-19	93.0	COG2703@1|root,COG2703@2|Bacteria	2|Bacteria	P	oxygen carrier activity	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HFD1_k127_4033071_1	234267.Acid_2399	5.998e-97	317.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,3Y343@57723|Acidobacteria	57723|Acidobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HFD1_k127_4053881_15	1353531.AZNX01000005_gene3327	1.509e-28	119.0	COG4287@1|root,COG4287@2|Bacteria,1NP5V@1224|Proteobacteria	1224|Proteobacteria	O	PhoPQ-activated pathogenicity-related protein	pqaA	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
HFD1_k127_4053881_4	234267.Acid_1244	3.607e-220	692.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD1_k127_4053881_0	234267.Acid_1243	0.0	1396.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD1_k127_4053881_14	1382359.JIAL01000001_gene1881	4.308e-49	177.0	COG1188@1|root,COG1188@2|Bacteria,3Y5C6@57723|Acidobacteria,2JJNN@204432|Acidobacteriia	204432|Acidobacteriia	J	RNA-binding S4 domain protein	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HFD1_k127_4053881_11	1198452.Jab_1c17790	3.413e-90	302.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2VQ6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4053881_1	234267.Acid_3483	1.148e-303	957.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,UnbV_ASPIC,VCBS
HFD1_k127_4053881_6	1340493.JNIF01000003_gene3581	6.294e-150	491.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_4053881_8	682795.AciX8_4545	4.718e-129	418.0	COG0583@1|root,COG0583@2|Bacteria,3Y3F1@57723|Acidobacteria,2JISX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_4053881_12	682795.AciX8_4543	3.833e-62	217.0	COG0454@1|root,COG0456@2|Bacteria,3Y53Q@57723|Acidobacteria,2JN01@204432|Acidobacteriia	204432|Acidobacteriia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_4053881_13	1116232.AHBF01000002_gene7486	3.061e-50	189.0	COG1917@1|root,COG1917@2|Bacteria,2IGRA@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4053881_9	1242864.D187_008417	3.914e-105	368.0	COG0793@1|root,COG0793@2|Bacteria,1RCVK@1224|Proteobacteria	1224|Proteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD1_k127_4053881_3	234267.Acid_2648	3.281e-244	769.0	COG2382@1|root,COG3386@1|root,COG2382@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase,SGL
HFD1_k127_4053881_2	234267.Acid_7735	1.097e-271	843.0	COG1032@1|root,COG1032@2|Bacteria,3Y4FB@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_4053881_7	573065.Astex_1943	3.451e-144	478.0	28KZU@1|root,2ZAF0@2|Bacteria,1R63I@1224|Proteobacteria,2UT9T@28211|Alphaproteobacteria,2KIVX@204458|Caulobacterales	204458|Caulobacterales	M	Polysaccharide lyase family 4, domain III	-	-	4.2.2.23	ko:K18195	-	-	-	-	ko00000,ko01000	-	PL4	-	CBM-like,Rhamnogal_lyase,fn3_3
HFD1_k127_4053881_10	1340493.JNIF01000004_gene606	1.447e-95	319.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_4053881_5	1340493.JNIF01000003_gene3440	3.169e-207	655.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,GSDH,Laminin_G_3
HFD1_k127_4054083_24	1121406.JAEX01000007_gene2393	5.284e-30	124.0	COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,42V4M@68525|delta/epsilon subdivisions,2WRKJ@28221|Deltaproteobacteria,2MDM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HFD1_k127_4054083_25	1120985.AUMI01000017_gene2583	5.941e-17	86.0	COG1366@1|root,COG1366@2|Bacteria,1VZCA@1239|Firmicutes,4H85Q@909932|Negativicutes	909932|Negativicutes	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HFD1_k127_4054083_16	234267.Acid_0583	6.692e-132	441.0	COG3191@1|root,COG3191@2|Bacteria,3Y6EN@57723|Acidobacteria	57723|Acidobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HFD1_k127_4054083_18	234267.Acid_0582	2.212e-118	394.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria	57723|Acidobacteria	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD1_k127_4054083_17	234267.Acid_0581	4.54e-123	399.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD1_k127_4054083_12	234267.Acid_0580	7.707e-161	513.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD1_k127_4054083_15	234267.Acid_0579	9.363e-134	440.0	COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria	57723|Acidobacteria	G	PFAM YdjC family protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
HFD1_k127_4054083_5	234267.Acid_4215	5.547e-202	643.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD1_k127_4054083_21	234267.Acid_5985	1.296e-50	202.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
HFD1_k127_4054083_23	234267.Acid_0591	9.153e-38	149.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD1_k127_4054083_8	234267.Acid_0592	1.932e-172	546.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD1_k127_4054083_3	234267.Acid_0456	7.022e-230	722.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,3Y62K@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_4054083_22	330214.NIDE3333	1.641e-38	150.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,3J0VE@40117|Nitrospirae	40117|Nitrospirae	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HFD1_k127_4054083_1	234267.Acid_7897	5.051e-318	993.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4054083_11	234267.Acid_7896	6.194e-161	512.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria	57723|Acidobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HFD1_k127_4054083_6	234267.Acid_7895	1.222e-198	646.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4054083_9	234267.Acid_7894	1.912e-171	544.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD1_k127_4054083_19	234267.Acid_7866	4.146e-111	371.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_4054083_10	234267.Acid_7865	1.383e-167	538.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	2|Bacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF_2,HATPase_c,HisKA_3,PAS,PAS_4,PAS_9,Pkinase
HFD1_k127_4054083_7	234267.Acid_2202	1.915e-173	568.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_4054083_4	1382359.JIAL01000001_gene2204	1.794e-207	654.0	COG0535@1|root,COG0535@2|Bacteria,3Y2JV@57723|Acidobacteria,2JI93@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HFD1_k127_4054083_14	234267.Acid_0172	4.915e-139	447.0	29WUK@1|root,30IG1@2|Bacteria,3Y5ZU@57723|Acidobacteria	57723|Acidobacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
HFD1_k127_4054083_0	234267.Acid_5837	0.0	1981.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HFD1_k127_4054083_2	234267.Acid_0174	7.967e-231	725.0	COG0673@1|root,COG0673@2|Bacteria,3Y4RG@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_4054083_13	1380390.JIAT01000013_gene124	2.369e-150	484.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD1_k127_4054083_20	234267.Acid_0505	6.006e-67	230.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria	57723|Acidobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD1_k127_4058847_8	234267.Acid_2027	7.338e-27	111.0	COG0466@1|root,COG0466@2|Bacteria,3Y3DI@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD1_k127_4058847_0	234267.Acid_2026	2.421e-259	801.0	COG1219@1|root,COG1219@2|Bacteria,3Y3MR@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD1_k127_4058847_1	234267.Acid_2025	7.497e-208	653.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria	57723|Acidobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD1_k127_4058847_2	234267.Acid_5766	4.847e-88	294.0	COG1994@1|root,COG1994@2|Bacteria,3Y58P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD1_k127_4058847_7	448385.sce0758	3.755e-43	171.0	COG2169@1|root,COG2169@2|Bacteria,1NICQ@1224|Proteobacteria,43EDD@68525|delta/epsilon subdivisions,2X81D@28221|Deltaproteobacteria,2Z3J7@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HFD1_k127_4058847_6	1254432.SCE1572_39360	2.646e-52	187.0	COG0346@1|root,COG0346@2|Bacteria,1RIAM@1224|Proteobacteria,43827@68525|delta/epsilon subdivisions,2X3CD@28221|Deltaproteobacteria,2YVE1@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_4058847_4	1392498.JQLH01000001_gene2189	5.792e-73	267.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1HZ7N@117743|Flavobacteriia,2PHQV@252356|Maribacter	976|Bacteroidetes	IQ	KR domain	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD1_k127_4058847_3	641524.ADICYQ_2340	3.247e-84	288.0	COG1595@1|root,COG1595@2|Bacteria,4NMAE@976|Bacteroidetes,47UIC@768503|Cytophagia	976|Bacteroidetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HFD1_k127_4058847_5	661478.OP10G_1743	3.556e-71	249.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127,RicinB_lectin_2
HFD1_k127_4059342_2	344747.PM8797T_17212	1.238e-11	72.0	COG1649@1|root,COG1649@2|Bacteria,2IX7D@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
HFD1_k127_4059342_1	468059.AUHA01000002_gene531	2.889e-95	320.0	29Z06@1|root,30KX7@2|Bacteria,4NZNI@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HFD1_k127_4059342_0	468059.AUHA01000002_gene532	4.227e-109	356.0	COG0521@1|root,COG0521@2|Bacteria,4NHNF@976|Bacteroidetes,1IP72@117747|Sphingobacteriia	976|Bacteroidetes	H	Starch-binding associating with outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	SusD-like,SusD-like_2
HFD1_k127_4081418_0	391598.FBBAL38_09852	2.548e-127	424.0	COG1520@1|root,COG1520@2|Bacteria,4NHPR@976|Bacteroidetes,1HXXS@117743|Flavobacteriia	976|Bacteroidetes	G	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
HFD1_k127_4081418_2	411464.DESPIG_01955	1.116e-33	134.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,42WVI@68525|delta/epsilon subdivisions,2WT2D@28221|Deltaproteobacteria,2MCSK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
HFD1_k127_4081418_3	864069.MicloDRAFT_00032410	2.759e-20	95.0	COG2944@1|root,COG2944@2|Bacteria,1PT1M@1224|Proteobacteria,2VCXD@28211|Alphaproteobacteria,1JWG4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Helix-turn-helix	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
HFD1_k127_4081418_4	234267.Acid_4921	2.156e-16	85.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Collagen
HFD1_k127_4081418_1	1267535.KB906767_gene5422	6.221e-99	332.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,3Y4NJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_4089962_1	234267.Acid_1254	2.306e-207	646.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria	57723|Acidobacteria	I	Myo-inositol-1-phosphate synthase, GAPDH domain protein	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HFD1_k127_4089962_2	234267.Acid_1255	2.687e-185	583.0	COG0451@1|root,COG0451@2|Bacteria,3Y5IZ@57723|Acidobacteria	57723|Acidobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD1_k127_4089962_7	234267.Acid_3768	1.231e-60	218.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_4089962_9	234267.Acid_4839	2.305e-51	184.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_4089962_4	234267.Acid_4838	8.967e-124	410.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD1_k127_4089962_5	234267.Acid_0388	5.554e-99	335.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD1_k127_4089962_3	234267.Acid_6768	3.155e-163	534.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_4089962_0	234267.Acid_1388	3.206e-234	757.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	dppX	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HFD1_k127_4089962_6	323259.Mhun_2196	3.044e-68	239.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_4089962_8	118005.AWNK01000006_gene1264	6.424e-55	210.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
HFD1_k127_4092281_3	861299.J421_2359	5.349e-37	153.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_2359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4092281_4	1183438.GKIL_4354	2.61e-12	68.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4092281_1	234267.Acid_6569	2.594e-261	822.0	COG3525@1|root,COG3525@2|Bacteria,3Y2P0@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Glycoside hydrolase, family 20	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
HFD1_k127_4092281_2	744872.Spica_2277	6.328e-87	298.0	COG0667@1|root,COG0667@2|Bacteria,2JBJ9@203691|Spirochaetes	203691|Spirochaetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_4092281_0	682795.AciX8_3228	1.218e-264	840.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_4095725_2	234267.Acid_1166	7.073e-24	101.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria	57723|Acidobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD1_k127_4095725_0	234267.Acid_1167	2.381e-230	718.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD1_k127_4095725_1	234267.Acid_1168	8.63e-38	143.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria	57723|Acidobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD1_k127_4126014_2	1122605.KB893625_gene1683	5.151e-167	539.0	COG1501@1|root,COG1501@2|Bacteria,4PKHN@976|Bacteroidetes,1IP35@117747|Sphingobacteriia	976|Bacteroidetes	G	He_PIG associated, NEW1 domain of bacterial glycohydrolase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	He_PIG,He_PIG_assoc,Melibiase_2,NPCBM
HFD1_k127_4126014_10	886293.Sinac_2219	5.183e-27	127.0	COG0824@1|root,COG0824@2|Bacteria,2J0QJ@203682|Planctomycetes	203682|Planctomycetes	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
HFD1_k127_4126014_3	313628.LNTAR_21530	1.188e-163	554.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,CBM_35,F5_F8_type_C,GDE_C,NPCBM_assoc,RicinB_lectin_2,Trehalase
HFD1_k127_4126014_4	886293.Sinac_0920	1.272e-125	414.0	COG0673@1|root,COG0673@2|Bacteria,2IWZW@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_4126014_0	234267.Acid_2762	3.404e-230	717.0	COG0823@1|root,COG0823@2|Bacteria,3Y2NB@57723|Acidobacteria	57723|Acidobacteria	U	Oligogalacturonate lyase	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	Pectate_lyase22
HFD1_k127_4126014_5	1121430.JMLG01000002_gene1056	2.994e-97	336.0	COG2898@1|root,COG2898@2|Bacteria,1TQI2@1239|Firmicutes,24BRW@186801|Clostridia,265IQ@186807|Peptococcaceae	186801|Clostridia	S	Uncharacterised conserved protein (DUF2156)	mprF	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HFD1_k127_4126014_9	1340493.JNIF01000003_gene3101	1.999e-35	153.0	COG0392@1|root,COG0392@2|Bacteria,3Y7S6@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HFD1_k127_4126014_1	234267.Acid_3075	2.518e-227	712.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD1_k127_4126014_6	1267535.KB906767_gene3888	5.57e-92	319.0	COG0642@1|root,COG2205@2|Bacteria,3Y2W3@57723|Acidobacteria,2JIDP@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA
HFD1_k127_4126014_7	234267.Acid_0071	6.052e-83	287.0	COG0745@1|root,COG0745@2|Bacteria,3Y4Q8@57723|Acidobacteria	57723|Acidobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_4126014_11	288000.BBta_6339	0.0001242	44.0	29FC2@1|root,3029R@2|Bacteria,1NGRV@1224|Proteobacteria,2UJN0@28211|Alphaproteobacteria,3K1UJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	F subunit of K+-transporting ATPase (Potass_KdpF)	QU41_31500	-	-	-	-	-	-	-	-	-	-	-	Potass_KdpF
HFD1_k127_4126014_8	1267535.KB906767_gene3883	3.766e-76	259.0	COG2060@1|root,COG2060@2|Bacteria,3Y2YP@57723|Acidobacteria,2JIFM@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HFD1_k127_4141654_1	234267.Acid_7519	7.507e-79	268.0	COG0631@1|root,COG0631@2|Bacteria,3Y4SV@57723|Acidobacteria	57723|Acidobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD1_k127_4141654_0	234267.Acid_7518	2.89e-140	451.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	hrpQ	-	4.6.1.1	ko:K01768,ko:K03220,ko:K10914	ko00230,ko02020,ko02024,ko02025,ko02026,ko04113,ko04213,ko05111,map00230,map02020,map02024,map02025,map02026,map04113,map04213,map05111	M00332,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02044,ko03000	3.A.6.1	-	-	FHA,Yop-YscD_cpl,Yop-YscD_ppl,cNMP_binding
HFD1_k127_4141654_2	1267533.KB906733_gene3281	1.273e-15	86.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_4144529_3	234267.Acid_4600	7.079e-106	353.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_4144529_1	234267.Acid_4598	1.073e-123	402.0	COG0253@1|root,COG0253@2|Bacteria,3Y4EC@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD1_k127_4144529_4	234267.Acid_4596	1.9e-78	274.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD1_k127_4144529_6	234267.Acid_4595	1.512e-40	153.0	COG0784@1|root,COG0784@2|Bacteria,3Y8JB@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4144529_0	32057.KB217478_gene3617	5.593e-181	578.0	COG0467@1|root,COG0467@2|Bacteria,1G2XC@1117|Cyanobacteria,1HTZ7@1161|Nostocales	1117|Cyanobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD1_k127_4144529_5	1469607.KK073768_gene824	1.408e-48	188.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1FZVR@1117|Cyanobacteria,1HJYS@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
HFD1_k127_4144529_2	243231.GSU2816	1.999e-118	409.0	COG2204@1|root,COG4191@1|root,COG5000@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,43TMC@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_4148596_12	234267.Acid_4089	1.307e-97	330.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_4148596_13	234267.Acid_4049	3.106e-74	259.0	COG0329@1|root,COG0329@2|Bacteria,3Y7V6@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD1_k127_4148596_2	234267.Acid_4050	1.687e-179	578.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9
HFD1_k127_4148596_3	1254432.SCE1572_31205	9.9e-166	533.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YUKP@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD1_k127_4148596_19	671143.DAMO_0845	3.438e-05	51.0	2EUJ6@1|root,33N15@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4148596_0	234267.Acid_4448	1.987e-239	746.0	COG0137@1|root,COG0137@2|Bacteria,3Y3DD@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the argininosuccinate synthase family. Type 2 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD1_k127_4148596_15	335283.Neut_1480	5.161e-27	114.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2WAFG@28216|Betaproteobacteria,373SZ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD1_k127_4148596_17	309807.SRU_0658	1.23e-20	94.0	COG5606@1|root,COG5606@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HFD1_k127_4148596_5	234267.Acid_3923	2.601e-159	514.0	COG1073@1|root,COG1073@2|Bacteria,3Y93F@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	-
HFD1_k127_4148596_10	234267.Acid_3917	5.338e-109	356.0	COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD1_k127_4148596_7	234267.Acid_3280	1.804e-134	437.0	COG1162@1|root,COG1162@2|Bacteria,3Y4PC@57723|Acidobacteria	57723|Acidobacteria	S	RsgA GTPase	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HFD1_k127_4148596_9	234267.Acid_3281	7.501e-118	383.0	COG3836@1|root,COG3836@2|Bacteria,3Y5ZN@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_4148596_14	1535287.JP74_05155	2.607e-32	131.0	COG3795@1|root,COG3795@2|Bacteria,1RH6U@1224|Proteobacteria,2U5GH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_4148596_11	234267.Acid_1554	5.415e-98	325.0	COG0546@1|root,COG0546@2|Bacteria,3Y5BW@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD1_k127_4148596_6	234267.Acid_1555	1.233e-141	456.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD1_k127_4148596_4	234267.Acid_1556	2.141e-159	509.0	COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD1_k127_4148596_16	1267535.KB906767_gene4761	1.473e-26	116.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_4148596_1	234267.Acid_5155	6.195e-220	696.0	COG1716@1|root,COG3829@1|root,COG1716@2|Bacteria,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
HFD1_k127_4148596_8	234267.Acid_3811	9.078e-123	394.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria	57723|Acidobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD1_k127_4154775_4	84531.JMTZ01000037_gene3564	2.778e-72	255.0	COG4447@1|root,COG4447@2|Bacteria,1NRDC@1224|Proteobacteria,1S0E3@1236|Gammaproteobacteria,1X7BC@135614|Xanthomonadales	135614|Xanthomonadales	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4154775_3	99598.Cal7507_3741	3.289e-81	280.0	29137@1|root,2ZNQP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4154775_0	335543.Sfum_0519	7.143e-146	470.0	COG0371@1|root,COG0371@2|Bacteria,1MWAE@1224|Proteobacteria,42PJS@68525|delta/epsilon subdivisions,2WJ69@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HFD1_k127_4154775_1	234267.Acid_0871	1.098e-117	410.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_0871|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_4154775_2	639030.JHVA01000001_gene2812	4.814e-99	330.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HFD1_k127_4154775_5	234267.Acid_3840	3.489e-51	187.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_4154775_6	246197.MXAN_1668	3.868e-20	103.0	COG3291@1|root,COG3291@2|Bacteria,1PER1@1224|Proteobacteria,435HB@68525|delta/epsilon subdivisions,2WZUY@28221|Deltaproteobacteria,2Z2T2@29|Myxococcales	28221|Deltaproteobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4159955_16	234267.Acid_3098	2.592e-23	100.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD1_k127_4159955_1	234267.Acid_3099	0.0	1062.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_4159955_4	316067.Geob_3570	1.109e-229	729.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD1_k127_4159955_13	316067.Geob_3569	5.605e-41	154.0	COG4251@1|root,COG4251@2|Bacteria,1N1KJ@1224|Proteobacteria,42W7E@68525|delta/epsilon subdivisions,2WSCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
HFD1_k127_4159955_14	497964.CfE428DRAFT_5867	8.197e-30	124.0	COG4251@1|root,COG4251@2|Bacteria,46WB9@74201|Verrucomicrobia	74201|Verrucomicrobia	T	KaiB	-	-	-	-	-	-	-	-	-	-	-	-	KaiB
HFD1_k127_4159955_12	234267.Acid_5814	5.713e-79	284.0	COG2461@1|root,COG4251@1|root,COG2461@2|Bacteria,COG4251@2|Bacteria,3Y99J@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_4,PAS_9
HFD1_k127_4159955_3	234267.Acid_3101	2.626e-276	852.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD1_k127_4159955_11	234267.Acid_3091	6.828e-87	303.0	COG4122@1|root,COG4122@2|Bacteria,3Y4X9@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HFD1_k127_4159955_5	234267.Acid_3090	4.521e-192	606.0	COG1804@1|root,COG1804@2|Bacteria,3Y7RD@57723|Acidobacteria	57723|Acidobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD1_k127_4159955_10	1267535.KB906767_gene5453	6.67e-104	359.0	COG2271@1|root,COG2271@2|Bacteria,3Y6PG@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_4159955_15	1267535.KB906767_gene5453	2.438e-26	112.0	COG2271@1|root,COG2271@2|Bacteria,3Y6PG@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_4159955_7	1125973.JNLC01000011_gene639	8.187e-151	485.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,3JRCS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glucose dehydrogenase C-terminus	MA20_31690	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_4159955_9	234267.Acid_3102	3.586e-111	365.0	COG0372@1|root,COG0372@2|Bacteria,3Y6MW@57723|Acidobacteria	57723|Acidobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD1_k127_4159955_0	234267.Acid_1957	0.0	1467.0	COG0457@1|root,COG0760@1|root,COG0457@2|Bacteria,COG0760@2|Bacteria,3Y67U@57723|Acidobacteria	57723|Acidobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD1_k127_4159955_8	234267.Acid_1958	6.355e-149	475.0	COG1999@1|root,COG1999@2|Bacteria,3Y5CC@57723|Acidobacteria	57723|Acidobacteria	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HFD1_k127_4159955_2	234267.Acid_1964	0.0	1007.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD1_k127_4159955_6	234267.Acid_1965	1.656e-162	521.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1965|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_417892_10	234267.Acid_4469	1.84e-28	116.0	COG2227@1|root,COG2227@2|Bacteria,3Y2SJ@57723|Acidobacteria	57723|Acidobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_417892_9	1340493.JNIF01000004_gene767	3.521e-34	137.0	COG0662@1|root,COG0662@2|Bacteria,3Y4MC@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_417892_7	401053.AciPR4_2737	6.684e-100	336.0	COG2159@1|root,COG2159@2|Bacteria,3Y7XT@57723|Acidobacteria,2JNXE@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_417892_5	861299.J421_4089	2.296e-150	488.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_417892_0	234267.Acid_1536	0.0	1080.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_417892_4	234267.Acid_1535	1.122e-188	600.0	COG0739@1|root,COG0739@2|Bacteria,3Y3GS@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD1_k127_417892_1	234267.Acid_6431	1.941e-298	924.0	COG0155@1|root,COG0155@2|Bacteria,3Y2R8@57723|Acidobacteria	57723|Acidobacteria	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HFD1_k127_417892_2	234267.Acid_6430	1.205e-262	815.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria	57723|Acidobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD1_k127_417892_8	1089547.KB913013_gene2552	1.172e-61	222.0	COG0697@1|root,COG0697@2|Bacteria,4NIDP@976|Bacteroidetes,47P0K@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_417892_3	234267.Acid_4257	2.608e-200	638.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HFD1_k127_417892_6	234267.Acid_4256	6.617e-126	412.0	COG0577@1|root,COG1131@1|root,COG0577@2|Bacteria,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	CcmA5	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_417892_11	1340493.JNIF01000003_gene1695	4.982e-21	96.0	2CEN7@1|root,2Z9XA@2|Bacteria,3Y7AS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4179756_1	234267.Acid_6572	3.835e-49	184.0	COG3391@1|root,COG5563@1|root,COG3391@2|Bacteria,COG5563@2|Bacteria,3Y6BC@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4195458_0	234267.Acid_7200	8.615e-127	408.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD1_k127_4195458_1	234267.Acid_7197	2.655e-120	403.0	COG1028@1|root,COG1028@2|Bacteria,3Y6TA@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_4195458_2	234267.Acid_7194	2.464e-113	384.0	COG0024@1|root,COG0024@2|Bacteria	2|Bacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD1_k127_4195458_3	1121013.P873_09275	8.655e-100	333.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1X4NG@135614|Xanthomonadales	135614|Xanthomonadales	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD1_k127_4195458_4	1123508.JH636441_gene3757	1.914e-14	76.0	COG4877@1|root,COG4877@2|Bacteria,2J4M8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4196467_6	234267.Acid_2209	9.388e-86	287.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
HFD1_k127_4196467_2	234267.Acid_2208	6.607e-271	841.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria	57723|Acidobacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
HFD1_k127_4196467_4	234267.Acid_2207	2.595e-116	380.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD1_k127_4196467_1	234267.Acid_4005	0.0	1007.0	COG1053@1|root,COG1053@2|Bacteria,3Y6S5@57723|Acidobacteria	57723|Acidobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD1_k127_4196467_8	861299.J421_0601	9.999e-63	232.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4196467_5	335543.Sfum_3112	1.594e-111	385.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_4196467_3	234267.Acid_3982	4.523e-145	465.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD1_k127_4196467_10	234267.Acid_5924	7.277e-55	220.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	NHL
HFD1_k127_4196467_9	867845.KI911784_gene2277	2.359e-55	222.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
HFD1_k127_4196467_7	234267.Acid_5705	3.195e-63	226.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,SBP_bac_10,T2SSG
HFD1_k127_4196467_0	234267.Acid_6443	0.0	1577.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD1_k127_4227063_4	1340493.JNIF01000003_gene4018	3.024e-46	184.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH
HFD1_k127_4227063_0	1267535.KB906767_gene4837	0.0	1030.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_4227063_6	1166018.FAES_1559	4.26e-10	70.0	COG0457@1|root,COG0457@2|Bacteria,4NG1I@976|Bacteroidetes,47M8A@768503|Cytophagia	976|Bacteroidetes	NU	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD1_k127_4227063_3	497964.CfE428DRAFT_2616	9.824e-89	311.0	28MB8@1|root,2ZAPS@2|Bacteria,46U9F@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4227063_1	1267535.KB906767_gene3809	6.9e-273	849.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3809|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4227063_2	234267.Acid_6224	2.225e-114	375.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD1_k127_4227063_5	234267.Acid_6223	9.687e-26	107.0	COG0054@1|root,COG0054@2|Bacteria,3Y3RR@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD1_k127_4228474_1	234267.Acid_2726	2.122e-74	263.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4228474_0	234267.Acid_5877	2.515e-133	449.0	COG2021@1|root,COG2021@2|Bacteria,3Y2FF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Alpha beta hydrolase	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_4228474_3	1267535.KB906767_gene4119	1.789e-12	81.0	COG2006@1|root,COG2006@2|Bacteria,3Y7N1@57723|Acidobacteria,2JNKP@204432|Acidobacteriia	204432|Acidobacteriia	S	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HFD1_k127_4242225_0	234267.Acid_4121	8.644e-253	794.0	COG4733@1|root,COG4733@2|Bacteria,3Y67A@57723|Acidobacteria	57723|Acidobacteria	S	Putative phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage-tail_3
HFD1_k127_424404_0	234267.Acid_7109	3.411e-134	430.0	COG3669@1|root,COG3669@2|Bacteria,3Y6KY@57723|Acidobacteria	57723|Acidobacteria	G	Alpha-L-fucosidase C-terminal domain	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HFD1_k127_424404_2	234267.Acid_0701	1.275e-79	278.0	COG1413@1|root,COG1413@2|Bacteria,3Y7N7@57723|Acidobacteria	57723|Acidobacteria	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_424404_5	234267.Acid_0992	1.026e-35	151.0	2B7KW@1|root,320RZ@2|Bacteria,3Y7ZF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_424404_3	234267.Acid_0991	6.066e-68	236.0	COG0637@1|root,COG0637@2|Bacteria,3Y49E@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD1_k127_424404_6	234267.Acid_0990	8.703e-34	135.0	2BW7N@1|root,32Z97@2|Bacteria,3Y8TS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_424404_4	234267.Acid_0988	5.728e-67	235.0	COG3571@1|root,COG3571@2|Bacteria,3Y7N8@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_5,Abhydrolase_6
HFD1_k127_424404_1	234267.Acid_0987	6.092e-95	312.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,3Y2UX@57723|Acidobacteria	57723|Acidobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K13503,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
HFD1_k127_4252423_0	234267.Acid_5744	1.833e-293	914.0	COG2304@1|root,COG2304@2|Bacteria,3Y6TM@57723|Acidobacteria	57723|Acidobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HFD1_k127_4252423_3	234267.Acid_5745	7.674e-150	477.0	COG1721@1|root,COG1721@2|Bacteria,3Y6DV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD1_k127_4252423_2	234267.Acid_5746	8.028e-172	546.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria	57723|Acidobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD1_k127_4252423_5	234267.Acid_0596	7.47e-135	435.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD1_k127_4252423_1	234267.Acid_0595	1.848e-230	728.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3Y2RK@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_4
HFD1_k127_4252423_4	234267.Acid_0439	6.938e-137	439.0	COG3569@1|root,COG3569@2|Bacteria,3Y332@57723|Acidobacteria	57723|Acidobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HFD1_k127_4257164_3	234267.Acid_3716	1.23e-22	98.0	COG0520@1|root,COG0520@2|Bacteria,3Y632@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_4257164_2	234267.Acid_2436	1.692e-42	171.0	COG3170@1|root,COG3170@2|Bacteria,3Y4RX@57723|Acidobacteria	57723|Acidobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4257164_0	234267.Acid_2435	2.904e-89	296.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD1_k127_4261728_0	234267.Acid_2590	3.257e-112	390.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
HFD1_k127_4264996_3	379066.GAU_2821	1.541e-40	156.0	2E1RX@1|root,32X1X@2|Bacteria,1ZUAS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4264996_1	379066.GAU_2821	1.947e-75	267.0	2E1RX@1|root,32X1X@2|Bacteria,1ZUAS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4264996_2	379066.GAU_2821	5.315e-73	261.0	2E1RX@1|root,32X1X@2|Bacteria,1ZUAS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4264996_0	234267.Acid_7271	1.346e-277	875.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD1_k127_4277155_2	234267.Acid_0972	2.565e-99	331.0	COG1708@1|root,COG1708@2|Bacteria,3Y7NX@57723|Acidobacteria	57723|Acidobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4277155_1	234267.Acid_0973	2.394e-105	347.0	COG1512@1|root,COG1512@2|Bacteria,3Y4JT@57723|Acidobacteria	57723|Acidobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD1_k127_4277155_0	234267.Acid_4224	0.0	2210.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_4224|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4277155_3	1267534.KB906760_gene1333	7.103e-60	211.0	COG4188@1|root,COG4188@2|Bacteria	2|Bacteria	KT	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HFD1_k127_4278342_4	1267535.KB906767_gene4218	2.034e-108	364.0	COG4354@1|root,COG4354@2|Bacteria,3Y2ZY@57723|Acidobacteria,2JHZE@204432|Acidobacteriia	204432|Acidobacteriia	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
HFD1_k127_4278342_5	886293.Sinac_7077	1.226e-13	79.0	COG0500@1|root,COG2226@2|Bacteria,2IZZG@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_4278342_2	234267.Acid_2650	9.737e-155	498.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K07799,ko:K21135	ko02020,map02020	M00648,M00822	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.35,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD1_k127_4278342_0	234267.Acid_2649	0.0	1545.0	COG0841@1|root,COG0841@2|Bacteria,3Y63J@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD1_k127_4278342_3	234267.Acid_3047	1.389e-133	434.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD1_k127_4278342_1	861299.J421_4036	2.56e-217	699.0	COG4774@1|root,COG4774@2|Bacteria,1ZTSY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,TonB_dep_Rec
HFD1_k127_4281235_3	234267.Acid_1590	2.305e-17	89.0	COG0457@1|root,COG0457@2|Bacteria,3Y7P3@57723|Acidobacteria	57723|Acidobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HFD1_k127_4281235_0	234267.Acid_1589	4.943e-217	685.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1589|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4281235_2	234267.Acid_7946	1.588e-32	145.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_4281235_1	234267.Acid_1587	3.289e-115	373.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria	57723|Acidobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD1_k127_4288485_2	1340493.JNIF01000003_gene3565	2.43e-27	121.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4288485_0	234267.Acid_3318	1.191e-317	992.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4288485_1	1047013.AQSP01000113_gene740	7.97e-130	422.0	COG1472@1|root,COG1472@2|Bacteria,2NNR4@2323|unclassified Bacteria	2|Bacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HFD1_k127_4288485_3	340.xcc-b100_4311	5.33e-08	54.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1X4AX@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HFD1_k127_4293083_1	234267.Acid_4494	3.819e-32	130.0	COG1595@1|root,COG1595@2|Bacteria,3Y7YB@57723|Acidobacteria	2|Bacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_4293083_0	234267.Acid_5676	1.192e-223	728.0	COG0515@1|root,COG1262@1|root,COG1506@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	1.14.99.50,2.7.11.1	ko:K01990,ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	M00254	R11013	RC03323,RC03324	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1	-	-	FGE-sulfatase,Peptidase_S15,Pkinase
HFD1_k127_4303540_0	234267.Acid_6284	8.434e-126	404.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_6284|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4303540_3	234267.Acid_4321	2.61e-79	289.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_4303540_4	234267.Acid_4320	1.122e-70	245.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_4303540_6	401053.AciPR4_2697	7.407e-19	102.0	COG0823@1|root,COG0823@2|Bacteria,3Y4FU@57723|Acidobacteria,2JJ6C@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM WD40-like beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_4303540_2	530564.Psta_3944	1.033e-81	287.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_4303540_5	269799.Gmet_0910	4.36e-29	132.0	COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,42VEM@68525|delta/epsilon subdivisions,2WRGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4303540_1	234267.Acid_1584	6.128e-122	399.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria	57723|Acidobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HFD1_k127_4303540_7	234267.Acid_1585	4.425e-15	74.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD1_k127_4318157_14	1340493.JNIF01000004_gene702	1.488e-92	315.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria	57723|Acidobacteria	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD1_k127_4318157_10	234267.Acid_0817	2.842e-101	338.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HFD1_k127_4318157_18	234267.Acid_2413	1.486e-63	232.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HFD1_k127_4318157_23	234267.Acid_6701	2.247e-29	126.0	2EEK4@1|root,338DZ@2|Bacteria,3Y5QV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_9	234267.Acid_6700	1.057e-127	412.0	COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria	57723|Acidobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD1_k127_4318157_5	234267.Acid_2457	3.6e-135	441.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	HHH_8,PHP
HFD1_k127_4318157_12	234267.Acid_6421	5.641e-99	345.0	COG0500@1|root,COG2226@2|Bacteria,3Y8SA@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_4318157_13	234267.Acid_6420	9.713e-98	326.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_3	234267.Acid_6419	1.109e-153	515.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	ymxG	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_4318157_6	234267.Acid_6418	3.896e-133	440.0	COG0612@1|root,COG0612@2|Bacteria,3Y5EP@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
HFD1_k127_4318157_22	234267.Acid_6417	7.04e-43	160.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	234267.Acid_6417|-	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_1	234267.Acid_6407	2.003e-202	637.0	COG0617@1|root,COG0617@2|Bacteria,3Y3U6@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	-	-	-	-	-	-	-	-	-	-	-	-	PolyA_pol
HFD1_k127_4318157_7	234267.Acid_6406	8.203e-133	439.0	COG4974@1|root,COG4974@2|Bacteria,3Y3D0@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD1_k127_4318157_20	234267.Acid_6405	4.345e-60	211.0	2C62N@1|root,32TCB@2|Bacteria,3Y55K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_8	234267.Acid_6404	1.047e-130	435.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HFD1_k127_4318157_25	234267.Acid_6403	5.235e-20	92.0	COG3350@1|root,COG3350@2|Bacteria,3Y90F@57723|Acidobacteria	57723|Acidobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_19	234267.Acid_7192	1.935e-63	220.0	COG2940@1|root,COG2940@2|Bacteria,3Y7R1@57723|Acidobacteria	57723|Acidobacteria	S	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD1_k127_4318157_15	234267.Acid_1562	5.523e-72	247.0	COG0526@1|root,COG0526@2|Bacteria,3Y4UN@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD1_k127_4318157_16	234267.Acid_1563	1.012e-67	231.0	COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria	57723|Acidobacteria	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD1_k127_4318157_17	234267.Acid_1564	2.306e-64	226.0	COG0720@1|root,COG0720@2|Bacteria,3Y56Y@57723|Acidobacteria	57723|Acidobacteria	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD1_k127_4318157_11	234267.Acid_1565	3.327e-99	328.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria	57723|Acidobacteria	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HFD1_k127_4318157_4	234267.Acid_3842	9.134e-146	475.0	COG1858@1|root,COG1858@2|Bacteria,3Y6XX@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4318157_21	1340493.JNIF01000003_gene4745	5.079e-45	174.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_4318157_2	234267.Acid_0871	2.238e-191	628.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_0871|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_4318157_0	234267.Acid_5961	5.748e-305	956.0	COG0577@1|root,COG0577@2|Bacteria,3Y7CU@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4318157_24	234267.Acid_5014	3.589e-24	104.0	COG0680@1|root,COG0680@2|Bacteria,3Y95V@57723|Acidobacteria	57723|Acidobacteria	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4346410_7	234267.Acid_6198	1.802e-25	108.0	COG0457@1|root,COG3342@1|root,COG0457@2|Bacteria,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HFD1_k127_4346410_1	118168.MC7420_1260	8.505e-187	594.0	COG1902@1|root,COG1902@2|Bacteria,1G2EB@1117|Cyanobacteria,1H8ZS@1150|Oscillatoriales	1117|Cyanobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HFD1_k127_4346410_0	234267.Acid_0434	0.0	1394.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,FAD_oxidored,GMC_oxred_C,GMC_oxred_N
HFD1_k127_4346410_3	1267533.KB906733_gene3154	5.179e-95	320.0	2F5SA@1|root,33YB5@2|Bacteria,3Y7SK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4346410_6	234267.Acid_4216	4.992e-45	173.0	COG4219@1|root,COG4219@2|Bacteria,3Y9A7@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_4346410_4	234267.Acid_3837	1.203e-90	317.0	COG3485@1|root,COG4932@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,DUF11,Gram_pos_anchor,SdrD_B
HFD1_k127_4346410_2	1340493.JNIF01000003_gene2267	2.049e-101	337.0	2BZ6M@1|root,2Z7HW@2|Bacteria	2|Bacteria	S	InterPro IPR010496	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_4346410_5	1267534.KB906754_gene3511	2.384e-75	257.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria	57723|Acidobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HFD1_k127_4354649_5	649743.HMPREF0972_01252	2.678e-05	52.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4D3V2@85005|Actinomycetales	201174|Actinobacteria	L	ComEA protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HFD1_k127_4354649_1	234267.Acid_3097	3.125e-146	478.0	COG4993@1|root,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_4354649_4	1125973.JNLC01000016_gene2722	5.833e-21	109.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUKX@28211|Alphaproteobacteria,3K49P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD1_k127_4354649_2	234267.Acid_3094	2.911e-110	372.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y59I@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4354649_3	234267.Acid_3094	2.444e-24	106.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y59I@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4354649_0	1267535.KB906767_gene4759	4.463e-213	689.0	COG1629@1|root,COG1629@2|Bacteria,3Y2N1@57723|Acidobacteria,2JIIP@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4355274_0	316056.RPC_1006	2.748e-272	858.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HFD1_k127_4355274_1	234267.Acid_1098	7.924e-138	445.0	COG2755@1|root,COG2755@2|Bacteria,3Y99T@57723|Acidobacteria	57723|Acidobacteria	E	Pectic acid lyase	-	-	-	-	-	-	-	-	-	-	-	-	Pec_lyase
HFD1_k127_4355274_2	234267.Acid_7728	1.582e-136	436.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_4360239_0	234267.Acid_1914	2.319e-218	681.0	COG0304@1|root,COG0304@2|Bacteria,3Y43C@57723|Acidobacteria	57723|Acidobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD1_k127_4360239_2	675635.Psed_1309	1.495e-07	60.0	2EJIE@1|root,33D9B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4360239_1	234267.Acid_1915	2.448e-87	292.0	COG0539@1|root,COG0539@2|Bacteria,3Y3P3@57723|Acidobacteria	57723|Acidobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD1_k127_4364952_6	1123278.KB893579_gene883	3.116e-07	53.0	28JZQ@1|root,2Z9PN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4364952_3	1267535.KB906767_gene1606	1.91e-45	172.0	COG3795@1|root,COG3795@2|Bacteria,3Y4T8@57723|Acidobacteria,2JN26@204432|Acidobacteriia	204432|Acidobacteriia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_4364952_1	234267.Acid_0024	6.76e-178	588.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_4364952_2	879212.DespoDRAFT_03731	2.521e-114	378.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MPYE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD1_k127_4364952_7	880073.Calab_2516	5.019e-06	51.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD1_k127_4364952_0	926549.KI421517_gene33	6.761e-239	777.0	COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,47JFT@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
HFD1_k127_4364952_4	1382359.JIAL01000001_gene1745	1.063e-42	170.0	COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria,2JITC@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_4385870_1	1173024.KI912148_gene4571	1.213e-121	394.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae	1117|Cyanobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD1_k127_4385870_0	234267.Acid_5629	2.95e-243	779.0	COG5512@1|root,COG5512@2|Bacteria,3Y7CI@57723|Acidobacteria	57723|Acidobacteria	S	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
HFD1_k127_4385870_2	234267.Acid_5628	2.24e-71	254.0	COG1214@1|root,COG1214@2|Bacteria,3Y5ED@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HFD1_k127_4385870_3	234267.Acid_5627	6.119e-10	60.0	COG0662@1|root,COG0662@2|Bacteria,3Y8MJ@57723|Acidobacteria	57723|Acidobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4392237_9	234267.Acid_0699	2.119e-57	211.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_4392237_11	909663.KI867150_gene69	7.464e-54	202.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4392237_5	234267.Acid_5823	1.831e-86	297.0	COG1680@1|root,COG1680@2|Bacteria,3Y6F4@57723|Acidobacteria	57723|Acidobacteria	V	PFAM Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
HFD1_k127_4392237_7	234267.Acid_3738	6.594e-63	228.0	2CAM1@1|root,301FE@2|Bacteria,3Y87M@57723|Acidobacteria	57723|Acidobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4392237_3	234267.Acid_4515	2.794e-156	507.0	COG1131@1|root,COG1131@2|Bacteria,3Y6FZ@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_4392237_4	234267.Acid_4516	5.068e-132	424.0	COG1277@1|root,COG1277@2|Bacteria,3Y6D0@57723|Acidobacteria	57723|Acidobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD1_k127_4392237_0	234267.Acid_4517	6.434e-214	673.0	COG3225@1|root,COG3225@2|Bacteria,3Y6WR@57723|Acidobacteria	57723|Acidobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HFD1_k127_4392237_2	234267.Acid_4518	7.626e-198	625.0	2ANCT@1|root,31DBC@2|Bacteria,3Y69A@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HFD1_k127_4392237_1	234267.Acid_4519	1.766e-203	640.0	COG1488@1|root,COG1488@2|Bacteria,3Y6U3@57723|Acidobacteria	57723|Acidobacteria	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HFD1_k127_4392237_6	234267.Acid_4520	1.655e-85	292.0	COG1335@1|root,COG1335@2|Bacteria,3Y7ZP@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD1_k127_4392237_12	903818.KI912268_gene1698	9.237e-30	124.0	COG0614@1|root,COG0614@2|Bacteria,3Y8G5@57723|Acidobacteria	57723|Acidobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD1_k127_4392237_13	443144.GM21_0588	1.048e-20	99.0	COG2259@1|root,COG2259@2|Bacteria,1NC5I@1224|Proteobacteria,42V27@68525|delta/epsilon subdivisions,2WS2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Methylamine	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HFD1_k127_4392237_10	234267.Acid_4523	3.576e-55	207.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_4392237_8	234267.Acid_4523	5.39e-61	216.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_4428670_0	234267.Acid_1165	1.173e-100	331.0	COG2025@1|root,COG2025@2|Bacteria,3Y4SJ@57723|Acidobacteria	57723|Acidobacteria	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD1_k127_4428670_1	234267.Acid_1164	2.771e-63	222.0	COG1734@1|root,COG1734@2|Bacteria,3Y5PJ@57723|Acidobacteria	57723|Acidobacteria	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD1_k127_4428670_3	234267.Acid_1162	7.49e-40	158.0	COG1923@1|root,COG1923@2|Bacteria,3Y59T@57723|Acidobacteria	57723|Acidobacteria	S	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HFD1_k127_4428670_2	1267535.KB906767_gene4617	1.949e-62	218.0	COG2262@1|root,COG2262@2|Bacteria,3Y2FK@57723|Acidobacteria,2JI0F@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD1_k127_4434959_0	1340493.JNIF01000003_gene1416	6.879e-284	879.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria	57723|Acidobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD1_k127_4434959_2	234267.Acid_6746	2.784e-49	177.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria	57723|Acidobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD1_k127_4434959_1	234267.Acid_6745	1.265e-75	257.0	COG0252@1|root,COG0252@2|Bacteria,3Y8TG@57723|Acidobacteria	57723|Acidobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HFD1_k127_444559_1	234267.Acid_3655	6.535e-264	838.0	COG0038@1|root,COG0457@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0457@2|Bacteria,COG0517@2|Bacteria,3Y2G4@57723|Acidobacteria	57723|Acidobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HFD1_k127_444559_4	234267.Acid_0888	1.823e-82	283.0	COG0760@1|root,COG0760@2|Bacteria,3Y890@57723|Acidobacteria	57723|Acidobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
HFD1_k127_444559_6	234267.Acid_0890	8.497e-34	134.0	2C9DB@1|root,2ZU09@2|Bacteria,3Y8XC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_444559_0	234267.Acid_0891	5.849e-268	829.0	COG1353@1|root,COG1353@2|Bacteria,3Y6EG@57723|Acidobacteria	57723|Acidobacteria	S	crispr-associated protein	-	-	-	ko:K07016	-	-	-	-	ko00000,ko02048	-	-	-	-
HFD1_k127_444559_5	234267.Acid_0892	2.279e-75	257.0	COG1421@1|root,COG1421@2|Bacteria,3Y7KM@57723|Acidobacteria	57723|Acidobacteria	L	Pfam:DUF310	-	-	-	-	-	-	-	-	-	-	-	-	Csm2_III-A
HFD1_k127_444559_2	234267.Acid_0893	4.924e-153	486.0	COG1337@1|root,COG1337@2|Bacteria,3Y6QK@57723|Acidobacteria	57723|Acidobacteria	L	RAMP superfamily	-	-	-	ko:K09002	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HFD1_k127_444559_3	234267.Acid_0894	1.636e-119	391.0	COG1567@1|root,COG1567@2|Bacteria,3Y72B@57723|Acidobacteria	57723|Acidobacteria	L	CRISPR-associated RAMP protein, Csm4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4463162_4	234267.Acid_3583	5.431e-87	308.0	COG1629@1|root,COG1629@2|Bacteria,3Y78S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_4463162_1	234267.Acid_3583	3.116e-189	634.0	COG1629@1|root,COG1629@2|Bacteria,3Y78S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_4463162_2	234267.Acid_3583	5.718e-188	631.0	COG1629@1|root,COG1629@2|Bacteria,3Y78S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_4463162_0	234267.Acid_0700	0.0	1094.0	COG0577@1|root,COG0577@2|Bacteria,3Y321@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4463162_8	234267.Acid_4536	6.624e-13	74.0	COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_4463162_5	234267.Acid_2512	1.421e-50	185.0	COG1595@1|root,COG1595@2|Bacteria,3Y8V2@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_4463162_9	886293.Sinac_6625	3.685e-08	64.0	COG2319@1|root,COG2319@2|Bacteria,2IXQP@203682|Planctomycetes	203682|Planctomycetes	M	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,WD40
HFD1_k127_4463162_3	682795.AciX8_3234	6.535e-99	327.0	COG1415@1|root,COG1415@2|Bacteria,3Y6D2@57723|Acidobacteria,2JKZS@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
HFD1_k127_4466030_2	1382359.JIAL01000001_gene1751	7.18e-13	69.0	COG4319@1|root,COG4319@2|Bacteria,3Y5BE@57723|Acidobacteria,2JJS4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HFD1_k127_4466030_0	443598.AUFA01000013_gene6694	9.426e-82	299.0	COG1075@1|root,COG1075@2|Bacteria,1R0B6@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4466030_1	335659.S23_44250	3.196e-71	250.0	COG0507@1|root,COG0507@2|Bacteria,1QWYF@1224|Proteobacteria,2TY51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1112 Superfamily I DNA and RNA helicases and helicase subunits	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4475262_8	234267.Acid_5424	1.516e-37	150.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
HFD1_k127_4475262_2	1267533.KB906736_gene842	6.032e-202	656.0	COG0577@1|root,COG0577@2|Bacteria,3Y75R@57723|Acidobacteria,2JMAH@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4475262_6	1278073.MYSTI_01725	3.044e-102	356.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
HFD1_k127_4475262_7	1254432.SCE1572_33565	6.934e-86	295.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2YU3D@29|Myxococcales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HFD1_k127_4475262_0	1340493.JNIF01000003_gene1440	2.066e-306	949.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
HFD1_k127_4475262_3	639030.JHVA01000001_gene112	3.066e-156	502.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD1_k127_4475262_5	234267.Acid_1480	1.97e-115	377.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HFD1_k127_4475262_1	485913.Krac_4320	1.875e-253	796.0	COG3962@1|root,COG3962@2|Bacteria,2G68S@200795|Chloroflexi	200795|Chloroflexi	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_4475262_4	234267.Acid_1484	3.749e-137	454.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	1.1.1.18,1.1.1.369,4.2.1.44	ko:K00010,ko:K03335	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R02782,R05659,R09951	RC00182,RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_4475262_9	234267.Acid_1485	8.16e-34	135.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_448588_4	234267.Acid_3586	3.443e-27	115.0	COG1404@1|root,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	57723|Acidobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD1_k127_448588_6	1122951.ATUE01000006_gene1408	2.282e-09	66.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,1S4KB@1236|Gammaproteobacteria,3NPC5@468|Moraxellaceae	1236|Gammaproteobacteria	S	PIN domain	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HFD1_k127_448588_0	234267.Acid_7248	3.143e-173	551.0	COG2041@1|root,COG2041@2|Bacteria,3Y7UP@57723|Acidobacteria	57723|Acidobacteria	C	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD1_k127_448588_3	234267.Acid_6376	1.629e-42	163.0	2E4EC@1|root,32Z9K@2|Bacteria,3Y5GG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD1_k127_448588_2	204669.Acid345_0658	1.184e-70	255.0	COG2159@1|root,COG2159@2|Bacteria,3Y2HY@57723|Acidobacteria,2JI2D@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_448588_1	234267.Acid_3622	5.042e-109	371.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_448966_2	234267.Acid_0683	3.882e-85	284.0	COG0673@1|root,COG0673@2|Bacteria,3Y6VS@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_448966_0	234267.Acid_3201	1.678e-228	716.0	COG2755@1|root,COG2755@2|Bacteria,3Y2P4@57723|Acidobacteria	57723|Acidobacteria	E	Pfam:DUF303	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
HFD1_k127_448966_4	234267.Acid_1888	1.315e-40	163.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_448966_1	234267.Acid_7258	7.162e-173	546.0	COG1940@1|root,COG1940@2|Bacteria,3Y43I@57723|Acidobacteria	57723|Acidobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
HFD1_k127_448966_3	234267.Acid_3529	1.74e-75	257.0	COG0169@1|root,COG0169@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HFD1_k127_4493623_2	234267.Acid_7663	6.554e-181	569.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
HFD1_k127_4493623_1	234267.Acid_7662	3.4e-240	746.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.55	ko:K00823,ko:K15372	ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R01684	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD1_k127_4493623_4	926566.Terro_4344	8.68e-123	421.0	COG0493@1|root,COG0493@2|Bacteria,3Y3EA@57723|Acidobacteria,2JJCC@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1,1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R10159,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HFD1_k127_4493623_0	234267.Acid_7660	2.637e-264	821.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,3Y3D8@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Dihydroorotate dehydrogenase	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
HFD1_k127_4493623_3	234267.Acid_7659	8.835e-126	404.0	COG0044@1|root,COG0044@2|Bacteria,3Y48H@57723|Acidobacteria	57723|Acidobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HFD1_k127_4495875_0	234267.Acid_4195	1.699e-64	226.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,3Y6CI@57723|Acidobacteria	57723|Acidobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_4495875_2	234267.Acid_4198	9.527e-33	130.0	28YJV@1|root,2ZKDM@2|Bacteria,3Y94S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_450827_5	234267.Acid_7454	6.783e-97	323.0	COG4786@1|root,COG4786@2|Bacteria,3Y2HI@57723|Acidobacteria	57723|Acidobacteria	N	basal body rod protein	-	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD1_k127_450827_2	234267.Acid_7453	1.719e-139	446.0	COG4786@1|root,COG4786@2|Bacteria,3Y3K1@57723|Acidobacteria	57723|Acidobacteria	N	flagellar basal-body rod protein FlgG	-	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD1_k127_450827_7	234267.Acid_7452	1.189e-73	273.0	COG1261@1|root,COG1261@2|Bacteria,3Y8G9@57723|Acidobacteria	57723|Acidobacteria	NO	Chaperone for flagella basal body P-ring formation	-	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
HFD1_k127_450827_9	234267.Acid_7451	3.11e-64	239.0	COG2063@1|root,COG2063@2|Bacteria,3Y3D6@57723|Acidobacteria	57723|Acidobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	-	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
HFD1_k127_450827_1	234267.Acid_7450	6.005e-163	519.0	COG1706@1|root,COG1706@2|Bacteria,3Y2UQ@57723|Acidobacteria	57723|Acidobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
HFD1_k127_450827_13	234267.Acid_7449	2.05e-17	84.0	COG3951@1|root,COG3951@2|Bacteria,3Y8ZC@57723|Acidobacteria	57723|Acidobacteria	MNO	Rod binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
HFD1_k127_450827_4	234267.Acid_0509	1.766e-105	347.0	COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HFD1_k127_450827_11	234267.Acid_0510	2.556e-51	185.0	COG0848@1|root,COG0848@2|Bacteria,3Y4QV@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD1_k127_450827_10	234267.Acid_0511	4.984e-57	215.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HFD1_k127_450827_0	234267.Acid_0512	8.524e-208	657.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD1_k127_450827_3	234267.Acid_0513	5.05e-115	383.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD1_k127_450827_6	234267.Acid_0514	6.979e-85	292.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria	57723|Acidobacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HFD1_k127_450827_8	234267.Acid_0515	2.203e-64	231.0	COG0274@1|root,COG0274@2|Bacteria,3Y2Q4@57723|Acidobacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD1_k127_450827_12	234267.Acid_7159	1.095e-30	134.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HFD1_k127_4508474_0	234267.Acid_7271	3.464e-111	363.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD1_k127_4508474_3	1234364.AMSF01000085_gene2950	9.161e-39	166.0	COG4485@1|root,COG4485@2|Bacteria,1PDH2@1224|Proteobacteria,1RW0I@1236|Gammaproteobacteria,1XBIQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD1_k127_4508474_1	234267.Acid_0285	3.155e-105	347.0	COG1215@1|root,COG1215@2|Bacteria,3Y6P7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD1_k127_4508474_2	395961.Cyan7425_0420	1.686e-72	250.0	COG0451@1|root,COG0451@2|Bacteria,1G457@1117|Cyanobacteria,3KJVY@43988|Cyanothece	1117|Cyanobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD1_k127_4513286_0	234267.Acid_4361	8.505e-68	232.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	57723|Acidobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HFD1_k127_4513286_2	234267.Acid_0095	3.417e-42	158.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4513286_1	234267.Acid_2433	2.427e-49	179.0	COG0792@1|root,COG0792@2|Bacteria,3Y56J@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HFD1_k127_4513286_3	1297570.MESS4_p40066	3.265e-14	76.0	COG0477@1|root,COG2814@2|Bacteria,1MXYJ@1224|Proteobacteria,2TXZ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_4513513_4	595460.RRSWK_05050	3.087e-29	133.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
HFD1_k127_4513513_2	234267.Acid_5604	3.794e-58	227.0	COG1075@1|root,COG3420@1|root,COG1075@2|Bacteria,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	Beta_helix,LCAT,Laminin_G_3,PGAP1
HFD1_k127_4513513_0	595460.RRSWK_05050	1.551e-72	271.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
HFD1_k127_4513513_3	385682.AFSL01000087_gene713	6.587e-37	158.0	COG1262@1|root,COG1262@2|Bacteria,4NFR2@976|Bacteroidetes,2FUVV@200643|Bacteroidia,3XKS5@558415|Marinilabiliaceae	976|Bacteroidetes	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HFD1_k127_4513513_1	573370.DMR_01540	2.624e-58	206.0	COG3678@1|root,COG3678@2|Bacteria,1NREX@1224|Proteobacteria	1224|Proteobacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4523733_4	452637.Oter_2464	1.883e-179	578.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,46TQW@74201|Verrucomicrobia,3K7GA@414999|Opitutae	74201|Verrucomicrobia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
HFD1_k127_4523733_7	452637.Oter_2463	1.693e-116	392.0	COG0651@1|root,COG0651@2|Bacteria,46UK3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HFD1_k127_4523733_12	452637.Oter_2462	5.798e-60	222.0	COG4237@1|root,COG4237@2|Bacteria,46W3G@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD1_k127_4523733_10	452637.Oter_2461	1.756e-99	360.0	COG0650@1|root,COG0650@2|Bacteria,46V7E@74201|Verrucomicrobia,3K7BZ@414999|Opitutae	74201|Verrucomicrobia	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HFD1_k127_4523733_2	452637.Oter_2460	1.715e-206	663.0	COG0651@1|root,COG0651@2|Bacteria,46U4G@74201|Verrucomicrobia,3K7M3@414999|Opitutae	74201|Verrucomicrobia	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HFD1_k127_4523733_11	1267533.KB906738_gene2207	1.084e-96	327.0	COG2885@1|root,COG2885@2|Bacteria,3Y7Y8@57723|Acidobacteria,2JMX3@204432|Acidobacteriia	204432|Acidobacteriia	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_4523733_18	1121405.dsmv_1129	0.0006973	45.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HFD1_k127_4523733_13	234267.Acid_3867	5.277e-34	134.0	COG4274@1|root,COG4274@2|Bacteria,3Y87J@57723|Acidobacteria	57723|Acidobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD1_k127_4523733_17	926566.Terro_0022	0.0005209	50.0	COG2027@1|root,COG2027@2|Bacteria,3Y87Q@57723|Acidobacteria,2JN8B@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_4523733_16	401053.AciPR4_4100	0.0005093	50.0	COG2027@1|root,COG2027@2|Bacteria,3Y64Y@57723|Acidobacteria,2JKU1@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_4523733_15	926566.Terro_0097	5.403e-14	75.0	COG2027@1|root,COG2027@2|Bacteria,3Y7ZS@57723|Acidobacteria,2JMZE@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_4523733_0	234267.Acid_6137	2.924e-307	977.0	COG4932@1|root,COG4932@2|Bacteria,3Y6F1@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4523733_8	1267535.KB906767_gene209	4.292e-100	342.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
HFD1_k127_4523733_1	886293.Sinac_6095	1.44e-208	669.0	COG1073@1|root,COG1073@2|Bacteria,2IYEI@203682|Planctomycetes	203682|Planctomycetes	Q	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD1_k127_4523733_9	234267.Acid_4451	1.718e-99	337.0	COG0673@1|root,COG0673@2|Bacteria,3Y71T@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_4523733_6	234267.Acid_3606	1.357e-167	568.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4523733_5	234267.Acid_3606	3.87e-170	571.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4523733_14	234267.Acid_6242	5.083e-33	130.0	COG1695@1|root,COG1695@2|Bacteria,3Y8BI@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_4523733_3	234267.Acid_3439	9.129e-200	627.0	COG4948@1|root,COG4948@2|Bacteria,3Y624@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_4523805_2	234267.Acid_0872	1.229e-06	52.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_4523805_0	401053.AciPR4_2539	1.436e-163	543.0	COG0577@1|root,COG0577@2|Bacteria,3Y6GK@57723|Acidobacteria,2JKI5@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4523805_1	234267.Acid_3106	2.09e-88	299.0	28HBM@1|root,2Z7NK@2|Bacteria,3Y6H0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4535066_2	335543.Sfum_0219	1.741e-150	498.0	COG0457@1|root,COG3118@1|root,COG3379@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42XTF@68525|delta/epsilon subdivisions,2WSZG@28221|Deltaproteobacteria,2MRX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_4535066_1	234267.Acid_1458	1.491e-155	498.0	COG2017@1|root,COG2017@2|Bacteria,3Y3D2@57723|Acidobacteria	57723|Acidobacteria	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD1_k127_4535066_5	234267.Acid_1457	1.578e-35	136.0	2A0AF@1|root,30NDV@2|Bacteria,3Y93U@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4535066_4	234267.Acid_1456	5.251e-38	147.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
HFD1_k127_4535066_0	234267.Acid_1455	2.506e-252	794.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
HFD1_k127_4535066_3	234267.Acid_1454	5e-119	388.0	COG1651@1|root,COG1651@2|Bacteria,3Y2G9@57723|Acidobacteria	57723|Acidobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DsbC_N,Thioredoxin_4
HFD1_k127_4543675_0	234267.Acid_7484	0.0	1067.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria	57723|Acidobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD1_k127_4543675_4	234267.Acid_7485	2.573e-34	136.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HFD1_k127_4543675_3	234267.Acid_7486	3.197e-51	185.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria	57723|Acidobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD1_k127_4543675_1	234267.Acid_7416	1.559e-164	524.0	COG1322@1|root,COG1322@2|Bacteria,3Y3R2@57723|Acidobacteria	57723|Acidobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD1_k127_4543675_2	1340493.JNIF01000004_gene68	9.011e-79	267.0	COG0114@1|root,COG0114@2|Bacteria,3Y9AP@57723|Acidobacteria	57723|Acidobacteria	C	Fumarase C C-terminus	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD1_k127_4545169_3	103733.JNYO01000066_gene1810	2.183e-06	55.0	2EI2I@1|root,33BTY@2|Bacteria,2H8RG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4545169_1	234267.Acid_5927	1.528e-98	345.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_4545169_0	1267533.KB906739_gene2594	7.542e-210	664.0	COG1231@1|root,COG1231@2|Bacteria	2|Bacteria	E	oxidoreductase activity	lao	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_4545169_2	1380390.JIAT01000009_gene493	1.422e-85	289.0	COG1231@1|root,COG1231@2|Bacteria,2I8ZQ@201174|Actinobacteria,4CRBP@84995|Rubrobacteria	84995|Rubrobacteria	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD1_k127_454708_6	864702.OsccyDRAFT_1804	5.832e-53	204.0	COG0793@1|root,COG0793@2|Bacteria,1G3PU@1117|Cyanobacteria,1HE19@1150|Oscillatoriales	1117|Cyanobacteria	E	Periplasmic protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD1_k127_454708_3	204669.Acid345_3116	7.513e-104	374.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
HFD1_k127_454708_1	1267535.KB906767_gene248	2.971e-154	492.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD1_k127_454708_2	234267.Acid_5572	3.484e-152	487.0	COG1820@1|root,COG1820@2|Bacteria,3Y3NQ@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD1_k127_454708_7	234267.Acid_4585	2.172e-47	182.0	COG0518@1|root,COG0518@2|Bacteria,3Y5C2@57723|Acidobacteria	57723|Acidobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HFD1_k127_454708_0	234267.Acid_4586	1.785e-157	508.0	COG0860@1|root,COG3266@1|root,COG0860@2|Bacteria,COG3266@2|Bacteria,3Y3M0@57723|Acidobacteria	57723|Acidobacteria	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HFD1_k127_454708_4	234267.Acid_4587	2.475e-63	234.0	COG0741@1|root,COG0741@2|Bacteria,3Y5CA@57723|Acidobacteria	57723|Acidobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
HFD1_k127_454708_5	234267.Acid_4588	4.475e-55	198.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	-	2.7.7.77,4.6.1.17	ko:K03637,ko:K03752,ko:K13818	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372,R11581	RC03425	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
HFD1_k127_454708_8	1340493.JNIF01000003_gene1726	3.595e-24	103.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria	57723|Acidobacteria	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD1_k127_4548412_5	251221.35211765	7.827e-145	489.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_4548412_3	234267.Acid_3991	9.228e-162	541.0	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4548412_12	234267.Acid_6242	2.808e-44	163.0	COG1695@1|root,COG1695@2|Bacteria,3Y8BI@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_4548412_11	1267535.KB906767_gene482	4.349e-60	209.0	COG0640@1|root,COG0640@2|Bacteria,3Y4ZD@57723|Acidobacteria,2JMYS@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HFD1_k127_4548412_8	1267535.KB906767_gene484	6.172e-88	303.0	COG3832@1|root,COG3832@2|Bacteria,3Y4SH@57723|Acidobacteria,2JN2B@204432|Acidobacteriia	204432|Acidobacteriia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_4548412_10	234267.Acid_3038	7.102e-62	215.0	COG2259@1|root,32Z45@2|Bacteria	2|Bacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
HFD1_k127_4548412_9	1267535.KB906767_gene486	6.28e-69	235.0	COG5649@1|root,COG5649@2|Bacteria,3Y4MQ@57723|Acidobacteria,2JJV2@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_4548412_0	1298867.AUES01000059_gene4743	1.06e-274	906.0	COG0642@1|root,COG0745@1|root,COG3920@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3920@2|Bacteria,1NRP8@1224|Proteobacteria,2TWTK@28211|Alphaproteobacteria,3K6XH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HWE_HK,HisKA,PAS_3,PAS_4,Response_reg
HFD1_k127_4548412_6	1122179.KB890471_gene442	8.693e-111	370.0	COG3525@1|root,COG3525@2|Bacteria,4NGV2@976|Bacteroidetes,1IRPA@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20
HFD1_k127_4548412_4	234267.Acid_3331	6.337e-155	503.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_4548412_1	1382359.JIAL01000001_gene1084	1.54e-202	646.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD1_k127_4548412_7	234267.Acid_1066	3.186e-97	327.0	28MK6@1|root,33VBX@2|Bacteria,3Y7JM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4548412_2	234267.Acid_1065	1.517e-196	617.0	COG2876@1|root,COG2876@2|Bacteria,3Y64W@57723|Acidobacteria	57723|Acidobacteria	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HFD1_k127_4561791_1	316055.RPE_4729	1.661e-40	168.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,3JUC9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD1_k127_4561791_0	234267.Acid_6495	3.36e-141	460.0	COG0577@1|root,COG0577@2|Bacteria,3Y6H1@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4630084_7	234267.Acid_5847	1.769e-52	190.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4630084_1	234267.Acid_2982	3.528e-290	929.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_2982|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4630084_6	234267.Acid_6384	3.406e-82	280.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria	57723|Acidobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD1_k127_4630084_4	234267.Acid_6383	1.38e-120	394.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD1_k127_4630084_2	234267.Acid_6381	4.249e-149	478.0	COG0859@1|root,COG0859@2|Bacteria,3Y6NF@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD1_k127_4630084_5	1185876.BN8_05865	7.116e-91	313.0	28HUE@1|root,2Z815@2|Bacteria,4NHK5@976|Bacteroidetes,47P9E@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
HFD1_k127_4630084_3	234267.Acid_5486	1.375e-130	424.0	COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria	2|Bacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4630084_0	234267.Acid_5485	0.0	1500.0	COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_4640777_2	1278073.MYSTI_00693	6.008e-261	811.0	COG0784@1|root,COG0840@1|root,COG2199@1|root,COG2770@1|root,COG5002@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BZ2@68525|delta/epsilon subdivisions,2X79T@28221|Deltaproteobacteria,2YU1H@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
HFD1_k127_4640777_11	525904.Tter_2799	1.287e-15	88.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
HFD1_k127_4640777_6	383372.Rcas_3813	3.139e-82	291.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
HFD1_k127_4640777_9	1267535.KB906767_gene3667	2.007e-50	186.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_4640777_5	1267535.KB906767_gene3668	4.439e-126	426.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_4640777_7	234267.Acid_4266	3.368e-61	222.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_4640777_8	234267.Acid_4216	3.57e-53	200.0	COG4219@1|root,COG4219@2|Bacteria,3Y9A7@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_4640777_0	1267535.KB906767_gene3671	0.0	1131.0	COG1629@1|root,COG4771@2|Bacteria,3Y6A1@57723|Acidobacteria,2JKK3@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4640777_1	234267.Acid_2620	5.968e-310	963.0	COG2304@1|root,COG2304@2|Bacteria,3Y3ER@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4640777_4	234267.Acid_0156	1.113e-133	431.0	COG0788@1|root,COG0788@2|Bacteria,3Y2N5@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
HFD1_k127_4640777_12	1185876.BN8_00717	2.787e-12	71.0	COG2730@1|root,COG2730@2|Bacteria,4NXWZ@976|Bacteroidetes,47WUS@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4640777_13	234267.Acid_7488	6.13e-10	66.0	COG3295@1|root,COG3295@2|Bacteria,3Y7GZ@57723|Acidobacteria	57723|Acidobacteria	S	Putative PepSY_TM-like	-	-	-	ko:K09939	-	-	-	-	ko00000	-	-	-	PepSY_TM_like_2
HFD1_k127_4640777_3	234267.Acid_3354	6.056e-160	514.0	COG1641@1|root,COG1641@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD1_k127_4640777_10	234267.Acid_3353	9.041e-33	131.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria	57723|Acidobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD1_k127_4641309_5	1270196.JCKI01000005_gene2818	9.222e-68	235.0	COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1IP3T@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	bga	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_4641309_3	452637.Oter_1159	4.483e-148	486.0	COG3867@1|root,COG3867@2|Bacteria,46VSS@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycosyl hydrolase 53 domain protein	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
HFD1_k127_4641309_1	682795.AciX8_3506	1.535e-220	707.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glyco_hydro_42,Glycos_transf_2
HFD1_k127_4641309_4	234267.Acid_1306	1.638e-146	507.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_4641309_6	234267.Acid_2683	5.745e-66	231.0	COG2197@1|root,COG2197@2|Bacteria,3Y4RP@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_4641309_0	234267.Acid_2684	4.504e-235	765.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2FS@57723|Acidobacteria	57723|Acidobacteria	T	Two component regulator three Y	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Reg_prop,Y_Y_Y
HFD1_k127_4641309_2	234267.Acid_4901	5.552e-149	490.0	COG3250@1|root,COG3250@2|Bacteria,3Y455@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_4659341_1	234267.Acid_0854	9.628e-90	299.0	COG1131@1|root,COG1131@2|Bacteria,3Y3PY@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_4659341_3	1206744.BAGL01000055_gene1534	7.609e-27	119.0	COG1695@1|root,COG1695@2|Bacteria,2GMKD@201174|Actinobacteria,4G1XT@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_4659341_0	234267.Acid_4173	6.681e-216	688.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4659341_2	234267.Acid_4173	5.242e-50	181.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4665669_3	234267.Acid_3431	5.79e-34	139.0	COG0727@1|root,COG0727@2|Bacteria,3Y7XA@57723|Acidobacteria	57723|Acidobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HFD1_k127_4665669_1	1267534.KB906754_gene3165	3.222e-82	278.0	COG2318@1|root,COG2318@2|Bacteria,3Y7B7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD1_k127_4665669_5	1297742.A176_05673	1.273e-09	65.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2X23U@28221|Deltaproteobacteria,2Z07E@29|Myxococcales	28221|Deltaproteobacteria	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD1_k127_4665669_4	1040982.AXAL01000002_gene5403	5.743e-11	69.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,43K2I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_4665669_0	234267.Acid_4305	5.822e-126	407.0	2DBN7@1|root,2ZA2Y@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_4667198_3	234267.Acid_2868	3.09e-67	234.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD1_k127_4667198_0	234267.Acid_2869	1.248e-169	545.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD1_k127_4667198_8	420324.KI912044_gene3907	9.457e-32	144.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,1JZD4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KT	helix_turn_helix, Lux Regulon	mctR	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_4667198_5	234267.Acid_1750	1.894e-44	172.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
HFD1_k127_4667198_7	316067.Geob_2055	2.617e-32	136.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4667198_2	234267.Acid_5493	3.332e-102	333.0	COG0693@1|root,COG0693@2|Bacteria,3Y79I@57723|Acidobacteria	57723|Acidobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD1_k127_4667198_1	1267535.KB906767_gene559	2.31e-111	364.0	COG4221@1|root,COG4221@2|Bacteria,3Y7F8@57723|Acidobacteria	57723|Acidobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_4667198_9	234267.Acid_4928	1.671e-26	119.0	29ZWG@1|root,30MXU@2|Bacteria,3Y5VK@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_4667198_6	401053.AciPR4_4136	1.912e-34	136.0	COG0346@1|root,COG0346@2|Bacteria,3Y7XQ@57723|Acidobacteria,2JMYD@204432|Acidobacteriia	204432|Acidobacteriia	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4667198_4	1121015.N789_03735	1.615e-56	202.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
HFD1_k127_4677169_0	234267.Acid_2857	0.0	1184.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria	57723|Acidobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD1_k127_4677169_1	234267.Acid_1083	9.993e-133	431.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	2|Bacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HFD1_k127_4677169_2	1267535.KB906767_gene4416	2.086e-128	418.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria,2JI06@204432|Acidobacteriia	57723|Acidobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_11,Hexapep
HFD1_k127_4677169_3	1163671.JAGI01000002_gene2543	0.0001769	49.0	COG0647@1|root,COG0647@2|Bacteria,1VDNE@1239|Firmicutes,24UBD@186801|Clostridia	186801|Clostridia	G	UMP catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4702035_8	886293.Sinac_7442	1.659e-123	412.0	COG0666@1|root,COG0666@2|Bacteria,2J2XP@203682|Planctomycetes	203682|Planctomycetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD1_k127_4702035_5	234267.Acid_2007	2.211e-140	451.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HFD1_k127_4702035_14	234267.Acid_2006	3.556e-50	183.0	2DWVU@1|root,3424P@2|Bacteria,3Y8CU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4702035_0	234267.Acid_2004	0.0	1185.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD1_k127_4702035_10	234267.Acid_2003	1.29e-92	311.0	COG0457@1|root,COG0457@2|Bacteria,3Y5A8@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HFD1_k127_4702035_6	234267.Acid_2002	2.724e-140	469.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_2002|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4702035_13	497964.CfE428DRAFT_4811	2.185e-71	262.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HFD1_k127_4702035_2	1267535.KB906767_gene1681	1.379e-188	597.0	COG0399@1|root,COG0399@2|Bacteria,3Y7K8@57723|Acidobacteria,2JK8Z@204432|Acidobacteriia	57723|Acidobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD1_k127_4702035_9	1340493.JNIF01000003_gene4569	3.536e-121	405.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
HFD1_k127_4702035_16	234267.Acid_4576	3.362e-22	103.0	COG2010@1|root,COG2010@2|Bacteria,3Y846@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_4702035_11	331113.SNE_A22880	5.5e-86	298.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HFD1_k127_4702035_1	234267.Acid_5922	9.347e-193	608.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD1_k127_4702035_12	1267533.KB906733_gene3426	1.409e-71	248.0	COG2318@1|root,COG2318@2|Bacteria,3Y53M@57723|Acidobacteria,2JN3W@204432|Acidobacteriia	204432|Acidobacteriia	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_4702035_7	234267.Acid_7686	3.762e-139	447.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4702035_4	234267.Acid_7687	8.863e-163	526.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_4702035_17	1123242.JH636434_gene4387	0.0001027	53.0	COG1277@1|root,COG1277@2|Bacteria,2J0ZV@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD1_k127_4702035_3	234267.Acid_7689	3.025e-182	572.0	COG1131@1|root,COG1131@2|Bacteria,3Y6U6@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_4717857_1	234267.Acid_6664	2.834e-195	615.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_4717857_0	234267.Acid_6663	1.577e-290	900.0	COG1649@1|root,COG1874@1|root,COG1649@2|Bacteria,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL10,GHL6,Glyco_hydro_42,Glyco_hydro_42M,Polysacc_deac_1
HFD1_k127_471865_14	234267.Acid_7143	2.753e-115	385.0	COG1256@1|root,COG1256@2|Bacteria,3Y2GW@57723|Acidobacteria	57723|Acidobacteria	N	TIGRFAM flagellar hook-associated protein FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD1_k127_471865_17	234267.Acid_7142	4.236e-91	308.0	COG1344@1|root,COG1344@2|Bacteria,3Y4HH@57723|Acidobacteria	57723|Acidobacteria	N	Bacterial flagellin N-terminal helical region	-	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HFD1_k127_471865_5	234267.Acid_7141	1.117e-211	663.0	COG0754@1|root,COG0754@2|Bacteria,3Y40H@57723|Acidobacteria	57723|Acidobacteria	E	PFAM glutathionylspermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	GSP_synth
HFD1_k127_471865_21	2074.JNYD01000015_gene4386	1.02e-34	143.0	COG1917@1|root,COG1917@2|Bacteria,2GWHB@201174|Actinobacteria,4EB3C@85010|Pseudonocardiales	201174|Actinobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HFD1_k127_471865_3	234267.Acid_4209	4.188e-299	943.0	COG0068@1|root,COG0068@2|Bacteria,3Y391@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HFD1_k127_471865_16	234267.Acid_6563	1.07e-91	305.0	COG0378@1|root,COG0378@2|Bacteria,3Y3AD@57723|Acidobacteria	57723|Acidobacteria	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HFD1_k127_471865_24	234267.Acid_6562	1.619e-14	80.0	COG0375@1|root,COG0375@2|Bacteria	2|Bacteria	S	nickel cation binding	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HFD1_k127_471865_12	682795.AciX8_4212	1.98e-127	430.0	COG0309@1|root,COG0309@2|Bacteria,3Y3UH@57723|Acidobacteria,2JK96@204432|Acidobacteriia	204432|Acidobacteriia	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HFD1_k127_471865_7	234267.Acid_6552	6.584e-180	571.0	COG0409@1|root,COG0409@2|Bacteria,3Y405@57723|Acidobacteria	57723|Acidobacteria	O	Hydrogenase formation hypA family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HFD1_k127_471865_23	1463936.JOJI01000024_gene1244	4.519e-25	106.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria	201174|Actinobacteria	O	Hydrogenase expression formation protein	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HFD1_k127_471865_2	1125863.JAFN01000001_gene1761	6.815e-306	967.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HFD1_k127_471865_15	1125863.JAFN01000001_gene1760	3.161e-113	383.0	COG3581@1|root,COG3581@2|Bacteria,1PDHS@1224|Proteobacteria,43DP1@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HFD1_k127_471865_1	234267.Acid_0409	0.0	1005.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD1_k127_471865_9	234267.Acid_0409	6.413e-159	503.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD1_k127_471865_20	234267.Acid_0410	5.876e-66	232.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD1_k127_471865_25	316274.Haur_1460	2.973e-11	67.0	COG0262@1|root,COG0262@2|Bacteria,2G9XM@200795|Chloroflexi,377RG@32061|Chloroflexia	32061|Chloroflexia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD1_k127_471865_11	234267.Acid_2431	7.671e-128	415.0	2F63Z@1|root,33YN9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_471865_13	234267.Acid_2543	4.591e-125	412.0	COG1503@1|root,COG1503@2|Bacteria,3Y6P2@57723|Acidobacteria	57723|Acidobacteria	J	eRF1 domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach,eRF1_3
HFD1_k127_471865_4	234267.Acid_2974	4.232e-283	908.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_471865_10	344747.PM8797T_15706	4.447e-140	464.0	COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_471865_6	1267535.KB906767_gene310	7.714e-201	649.0	COG3964@1|root,COG3964@2|Bacteria,3Y42F@57723|Acidobacteria	57723|Acidobacteria	S	amidohydrolase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_471865_18	1267535.KB906767_gene309	2.302e-82	285.0	2F4BE@1|root,33X1Z@2|Bacteria,3Y7SI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_471865_8	234267.Acid_6147	1.935e-174	554.0	COG2006@1|root,COG2006@2|Bacteria,3Y705@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD1_k127_471865_0	1267535.KB906767_gene5041	0.0	1082.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZC@57723|Acidobacteria,2JK8R@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_471865_22	460265.Mnod_7349	1.084e-29	132.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HFD1_k127_472532_0	1123508.JH636439_gene821	2.869e-137	472.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,2IYNB@203682|Planctomycetes	203682|Planctomycetes	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HFD1_k127_4738633_1	237368.SCABRO_00580	2.385e-105	374.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
HFD1_k127_4738633_5	237368.SCABRO_02550	9.91e-46	190.0	COG2303@1|root,COG3485@1|root,COG2303@2|Bacteria,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	choD_1	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	CarboxypepD_reg,FAD_oxidored,GMC_oxred_C,GMC_oxred_N,PhoD
HFD1_k127_4738633_2	880071.Fleli_2790	6.885e-95	327.0	COG1409@1|root,COG1409@2|Bacteria,4P3GR@976|Bacteroidetes	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_4738633_10	886293.Sinac_0162	1.714e-12	74.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	1.14.18.1	ko:K00505,ko:K02674	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	-	-	-	Neisseria_PilC,Tyrosinase,VWA_2
HFD1_k127_4738633_0	234267.Acid_4999	5.412e-199	635.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HFD1_k127_4738633_9	649638.Trad_1357	1.569e-24	112.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	PE-PPE,VKG_Carbox
HFD1_k127_4738633_3	234267.Acid_2866	9.873e-91	314.0	2DBU8@1|root,2ZB4S@2|Bacteria,3Y31B@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HFD1_k127_4738633_6	234267.Acid_4191	1.159e-30	122.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_4738633_11	379066.GAU_0897	4.564e-08	65.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_4738633_4	234267.Acid_4192	3.984e-81	284.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,3Y5BR@57723|Acidobacteria	57723|Acidobacteria	K	helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HFD1_k127_4738633_7	1144307.PMI04_00246	2.018e-29	123.0	2DEZ8@1|root,2ZPV2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4738633_8	234267.Acid_5553	2.9e-27	121.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_4806113_0	1280947.HY30_15865	8.168e-139	463.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43X6D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	CG	alcohol dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_4806113_1	452662.SJA_C2-00950	2.971e-09	70.0	COG3258@1|root,COG3258@2|Bacteria,1R0F2@1224|Proteobacteria,2TYQH@28211|Alphaproteobacteria,2K6ZI@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_4811560_1	1382359.JIAL01000001_gene2418	1.844e-06	61.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD1_k127_4811560_0	234267.Acid_7817	5.061e-53	190.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	-
HFD1_k127_4821985_8	485918.Cpin_3146	0.0009642	46.0	COG0639@1|root,COG0639@2|Bacteria,4NME8@976|Bacteroidetes,1IUY5@117747|Sphingobacteriia	976|Bacteroidetes	T	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_4821985_2	264732.Moth_1811	1.066e-259	831.0	COG3280@1|root,COG3280@2|Bacteria,1UERK@1239|Firmicutes,25JR7@186801|Clostridia,42HXY@68295|Thermoanaerobacterales	186801|Clostridia	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HFD1_k127_4821985_0	204669.Acid345_1485	0.0	1392.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,3Y2RE@57723|Acidobacteria,2JHM7@204432|Acidobacteriia	204432|Acidobacteriia	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HFD1_k127_4821985_7	234267.Acid_1497	1.304e-08	59.0	2DF57@1|root,2ZQIC@2|Bacteria,3Y8V0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
HFD1_k127_4821985_5	697282.Mettu_3570	6.282e-12	67.0	COG4636@1|root,COG4636@2|Bacteria,1RDIC@1224|Proteobacteria,1S6NM@1236|Gammaproteobacteria,1XFTV@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_4821985_1	234267.Acid_4088	0.0	1224.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_4821985_6	224914.BMEI0568	1.446e-11	66.0	2ENFV@1|root,33G39@2|Bacteria,1NP5K@1224|Proteobacteria,2UJUH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4821985_4	582515.KR51_00026520	1.205e-30	134.0	COG4671@1|root,COG4671@2|Bacteria,1G142@1117|Cyanobacteria	1117|Cyanobacteria	S	Glycosyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4822437_1	234267.Acid_3576	1.294e-93	310.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD1_k127_4822437_0	234267.Acid_3571	3.261e-110	359.0	COG0558@1|root,COG0558@2|Bacteria,3Y4PW@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HFD1_k127_4822437_4	234267.Acid_3570	7.717e-33	145.0	COG2246@1|root,COG2246@2|Bacteria,3Y5HC@57723|Acidobacteria	57723|Acidobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HFD1_k127_4822437_6	1267535.KB906767_gene251	1.043e-12	72.0	COG5487@1|root,COG5487@2|Bacteria	2|Bacteria	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HFD1_k127_4822437_3	234267.Acid_3568	2.796e-62	218.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HFD1_k127_4829124_6	234267.Acid_7357	6.607e-122	393.0	COG0318@1|root,COG0318@2|Bacteria,3Y68M@57723|Acidobacteria	57723|Acidobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD1_k127_4829124_5	234267.Acid_7358	2.189e-125	417.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100,4.2.1.17	ko:K01715,ko:K07537	ko00362,ko00650,ko01100,ko01120,ko01200,ko01220,map00362,map00650,map01100,map01120,map01200,map01220	M00541	R03026,R05597	RC00831,RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD1_k127_4829124_8	234267.Acid_7900	5.222e-34	137.0	COG1846@1|root,COG1846@2|Bacteria,3Y5RB@57723|Acidobacteria	57723|Acidobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD1_k127_4829124_0	234267.Acid_7899	2.422e-284	890.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,3Y2I6@57723|Acidobacteria	57723|Acidobacteria	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
HFD1_k127_4829124_7	1267535.KB906767_gene3668	1.032e-35	146.0	COG4219@1|root,COG4219@2|Bacteria,3Y4QS@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_4829124_2	1248916.ANFY01000007_gene2531	5.762e-198	656.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2K16Q@204457|Sphingomonadales	204457|Sphingomonadales	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_4829124_1	1267535.KB906767_gene1346	1.13e-221	698.0	COG3664@1|root,COG3664@2|Bacteria,3Y3B7@57723|Acidobacteria,2JKTF@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
HFD1_k127_4829124_4	234267.Acid_1178	3.242e-140	448.0	COG1692@1|root,COG1692@2|Bacteria,3Y3YJ@57723|Acidobacteria	57723|Acidobacteria	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HFD1_k127_4829124_3	234267.Acid_1179	5.848e-186	588.0	COG2199@1|root,COG2199@2|Bacteria,3Y7PX@57723|Acidobacteria	57723|Acidobacteria	T	TIGRFAM diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD1_k127_4830455_1	234267.Acid_7055	3.309e-197	620.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD1_k127_4830455_5	234267.Acid_7054	1.93e-146	467.0	COG0077@1|root,COG0077@2|Bacteria,3Y49H@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HFD1_k127_4830455_11	234267.Acid_7053	6.515e-86	287.0	COG0163@1|root,COG0163@2|Bacteria,3Y2S8@57723|Acidobacteria	57723|Acidobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	-	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HFD1_k127_4830455_17	1122612.AUBA01000003_gene1577	3.578e-13	79.0	COG0840@1|root,COG0840@2|Bacteria,1PDV9@1224|Proteobacteria,2V0U3@28211|Alphaproteobacteria,2KASQ@204457|Sphingomonadales	204457|Sphingomonadales	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CZB
HFD1_k127_4830455_7	234267.Acid_7049	2.497e-122	396.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria	57723|Acidobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4830455_2	234267.Acid_7048	1.67e-171	542.0	COG0332@1|root,COG0332@2|Bacteria,3Y2Z5@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD1_k127_4830455_6	331113.SNE_A06750	3.126e-143	471.0	COG0664@1|root,COG1252@1|root,COG0664@2|Bacteria,COG1252@2|Bacteria,2JFCT@204428|Chlamydiae	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885,ko:K10716	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Abhydrolase_6,CBS,Ion_trans,Pyr_redox_2,cNMP_binding
HFD1_k127_4830455_3	234267.Acid_7047	4.571e-169	543.0	2F7Z0@1|root,340CS@2|Bacteria,3Y88S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4830455_8	234267.Acid_7056	6.919e-116	381.0	COG0846@1|root,COG0846@2|Bacteria,3Y4T9@57723|Acidobacteria	57723|Acidobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD1_k127_4830455_14	929556.Solca_4001	1.256e-28	124.0	2E74W@1|root,331P9@2|Bacteria,4P4VB@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HFD1_k127_4830455_16	234267.Acid_5940	2.193e-15	82.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_4830455_0	234267.Acid_7817	0.0	1896.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	-
HFD1_k127_4830455_4	234267.Acid_1153	5.916e-162	513.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HFD1_k127_4830455_9	291112.PAU_02187	1.457e-110	374.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	histidine ammonia-lyase	-	-	4.3.1.24	ko:K10775	ko00360,ko00940,ko01100,ko01110,map00360,map00940,map01100,map01110	M00039,M00137,M00350	R00697	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD1_k127_4830455_10	234267.Acid_6444	2.954e-106	353.0	2F776@1|root,33ZNH@2|Bacteria,3Y8A6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4830455_12	864051.BurJ1DRAFT_4413	6.752e-68	234.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD1_k127_4835962_5	234267.Acid_2135	1.579e-59	208.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD1_k127_4835962_3	234267.Acid_1266	1.304e-132	441.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD1_k127_4835962_2	234267.Acid_1265	2.699e-153	492.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HFD1_k127_4835962_1	234267.Acid_1264	3.72e-197	617.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_4835962_0	234267.Acid_1263	8.577e-203	636.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_4835962_4	234267.Acid_1261	4.472e-91	301.0	COG0451@1|root,COG0451@2|Bacteria,3Y41S@57723|Acidobacteria	57723|Acidobacteria	M	epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HFD1_k127_4836170_0	1510531.JQJJ01000012_gene1686	1.492e-235	737.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,3JVN3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	fdhA1	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD1_k127_4839480_1	234267.Acid_7924	1.949e-62	218.0	2BMF1@1|root,32FZM@2|Bacteria,3Y8ZK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4839480_2	1267535.KB906767_gene311	8.057e-49	191.0	COG0251@1|root,COG0251@2|Bacteria,3Y4PU@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD1_k127_4839480_0	234267.Acid_6148	4.17e-234	735.0	COG1921@1|root,COG1921@2|Bacteria,3Y6KN@57723|Acidobacteria	57723|Acidobacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4839614_3	697281.Mahau_2725	1.383e-77	268.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,24B2U@186801|Clostridia,42IQ4@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD1_k127_4839614_2	204669.Acid345_4390	6.891e-110	388.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_4839614_0	234267.Acid_6969	4.438e-205	645.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HFD1_k127_4839614_1	234267.Acid_5386	3.623e-121	407.0	COG2264@1|root,COG2264@2|Bacteria,3Y3UA@57723|Acidobacteria	57723|Acidobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD1_k127_4839614_4	234267.Acid_7154	6.351e-09	66.0	COG3119@1|root,COG3119@2|Bacteria,3Y5BN@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_4840481_3	1122917.KB899661_gene1024	7.417e-185	603.0	COG5492@1|root,COG5492@2|Bacteria,1TQ2K@1239|Firmicutes,4HBG8@91061|Bacilli,26R5R@186822|Paenibacillaceae	91061|Bacilli	N	polysaccharide lyase family 8 domain protein	hylB	GO:0005575,GO:0005576	4.2.2.1	ko:K01727	-	-	-	-	ko00000,ko01000	-	PL8	-	Big_2,FIVAR,Gram_pos_anchor,Lyase_8,Lyase_8_C,Lyase_8_N,YSIRK_signal
HFD1_k127_4840481_22	1173028.ANKO01000114_gene6148	1.723e-11	72.0	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria,1H7BV@1150|Oscillatoriales	1117|Cyanobacteria	S	COG0666 FOG Ankyrin repeat	ank	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
HFD1_k127_4840481_1	234267.Acid_0007	2.212e-230	733.0	COG0457@1|root,COG0457@2|Bacteria,3Y3D1@57723|Acidobacteria	57723|Acidobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4840481_10	234267.Acid_0006	3.358e-84	287.0	COG1999@1|root,COG5569@1|root,COG1999@2|Bacteria,COG5569@2|Bacteria,3Y5CC@57723|Acidobacteria	57723|Acidobacteria	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HFD1_k127_4840481_0	234267.Acid_1149	2.092e-302	941.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y639@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ
HFD1_k127_4840481_11	489825.LYNGBM3L_21480	4.635e-40	156.0	2DNS7@1|root,32YWC@2|Bacteria,1G8QD@1117|Cyanobacteria,1HGCH@1150|Oscillatoriales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD1_k127_4840481_4	234267.Acid_1666	1.715e-151	490.0	COG1538@1|root,COG1538@2|Bacteria,3Y4MP@57723|Acidobacteria	57723|Acidobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_4840481_15	1463903.JOIZ01000005_gene2870	3.576e-24	106.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD1_k127_4840481_12	234267.Acid_4616	4.255e-32	143.0	COG2199@1|root,COG3706@2|Bacteria,3Y4ZC@57723|Acidobacteria	57723|Acidobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HFD1_k127_4840481_18	1382356.JQMP01000003_gene1429	5.025e-18	98.0	COG4585@1|root,COG5000@1|root,COG4585@2|Bacteria,COG5000@2|Bacteria,2G7ZR@200795|Chloroflexi,27YV8@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
HFD1_k127_4840481_7	234267.Acid_1137	9.708e-89	306.0	COG0784@1|root,COG4963@1|root,COG0784@2|Bacteria,COG4963@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K02282,ko:K02657,ko:K20972	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035,ko02044	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
HFD1_k127_4840481_6	234267.Acid_5601	7.142e-116	402.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4840481_8	234267.Acid_3957	1.715e-88	304.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans
HFD1_k127_4840481_20	313595.P700755_003211	1.393e-13	75.0	COG3631@1|root,COG3631@2|Bacteria,4NPKS@976|Bacteroidetes,1I2EQ@117743|Flavobacteriia,4C4CT@83612|Psychroflexus	976|Bacteroidetes	M	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	DUF4440,SnoaL,SnoaL_2
HFD1_k127_4840481_19	234267.Acid_4217	1.24e-14	88.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
HFD1_k127_4840481_21	234267.Acid_4218	9.105e-12	68.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
HFD1_k127_4840481_5	234267.Acid_4219	4.07e-120	397.0	COG4963@1|root,COG4963@2|Bacteria	2|Bacteria	-	-	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
HFD1_k127_4840481_2	234267.Acid_4163	8.909e-186	593.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria	57723|Acidobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4840481_13	234267.Acid_4162	7.56e-29	134.0	COG1989@1|root,COG1989@2|Bacteria	2|Bacteria	NOU	aspartic-type endopeptidase activity	-	-	3.4.23.43	ko:K02278,ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD1_k127_4840481_9	234267.Acid_4161	2.316e-85	300.0	COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria	57723|Acidobacteria	U	PFAM SAF domain	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD1_k127_4840481_14	1340493.JNIF01000003_gene3295	4.156e-26	123.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD1_k127_4841662_3	105425.BBPL01000035_gene4152	0.000145	55.0	COG0457@1|root,COG0457@2|Bacteria,2HPQU@201174|Actinobacteria,2NK23@228398|Streptacidiphilus	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4841662_0	234267.Acid_1389	0.0	1635.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_4841662_2	234267.Acid_1602	9.421e-218	687.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	ycf46	-	3.6.4.6	ko:K06027	ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962	-	-	-	ko00000,ko00001,ko01000,ko04131	1.F.1.1	-	-	AAA
HFD1_k127_4841662_1	234267.Acid_4041	6.3e-235	736.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Beta_helix,CBM_6,F5_F8_type_C,Hepar_II_III,Hepar_II_III_N
HFD1_k127_4845761_2	234267.Acid_3784	7.76e-91	300.0	COG0177@1|root,COG0177@2|Bacteria,3Y3QD@57723|Acidobacteria	57723|Acidobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD1_k127_4845761_1	1340493.JNIF01000004_gene789	3.571e-117	391.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepPQ	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD1_k127_4845761_0	1267535.KB906767_gene2456	1.423e-142	458.0	COG1752@1|root,COG1752@2|Bacteria,3Y6DZ@57723|Acidobacteria,2JMMY@204432|Acidobacteriia	204432|Acidobacteriia	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD1_k127_4849409_2	1396418.BATQ01000163_gene1988	1.37e-74	261.0	COG1968@1|root,COG1968@2|Bacteria,46SP6@74201|Verrucomicrobia,2IURU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	Bacitracin resistance protein BacA	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD1_k127_4849409_1	234267.Acid_7025	3.769e-80	275.0	2F5GG@1|root,33Y23@2|Bacteria,3Y7UU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4849409_0	1340493.JNIF01000003_gene2517	4.404e-248	798.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4851400_1	562970.Btus_1382	4.853e-06	51.0	COG0567@1|root,COG0567@2|Bacteria,1TRDW@1239|Firmicutes,4HAUI@91061|Bacilli,279I7@186823|Alicyclobacillaceae	91061|Bacilli	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	odhA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HFD1_k127_4851400_0	401053.AciPR4_0630	9.368e-28	128.0	2F59X@1|root,33XW3@2|Bacteria,3Y7Z5@57723|Acidobacteria,2JN0M@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4857014_0	234267.Acid_2220	1.171e-241	757.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD1_k127_4857014_3	234267.Acid_2219	2.287e-45	179.0	COG0784@1|root,COG0784@2|Bacteria,3Y4W5@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_4857014_1	234267.Acid_2218	3.672e-161	515.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD1_k127_4857014_4	234267.Acid_3821	4.339e-14	75.0	COG3609@1|root,COG3609@2|Bacteria,3Y8K2@57723|Acidobacteria	57723|Acidobacteria	K	addiction module antidote protein, CC2985 family	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	ParD_antitoxin
HFD1_k127_4857014_2	234267.Acid_2217	1.282e-98	327.0	COG0705@1|root,COG0705@2|Bacteria,3Y45U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD1_k127_4868251_0	886293.Sinac_5717	9.066e-237	745.0	COG3119@1|root,COG3119@2|Bacteria,2IXWN@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_4868251_3	1340493.JNIF01000003_gene2612	1.497e-102	357.0	COG0327@1|root,COG0327@2|Bacteria,3Y49T@57723|Acidobacteria	57723|Acidobacteria	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HFD1_k127_4868251_1	1267534.KB906756_gene343	1.696e-205	647.0	COG0412@1|root,COG0412@2|Bacteria,3Y2PZ@57723|Acidobacteria,2JKJA@204432|Acidobacteriia	204432|Acidobacteriia	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4868251_5	1469607.KK073768_gene4395	2.355e-14	78.0	COG4113@1|root,COG4113@2|Bacteria,1G6NY@1117|Cyanobacteria,1HPH0@1161|Nostocales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_4868251_2	234267.Acid_0353	4.126e-136	434.0	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD1_k127_4878476_4	234267.Acid_4901	3.777e-302	936.0	COG3250@1|root,COG3250@2|Bacteria,3Y455@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_4878476_7	497964.CfE428DRAFT_4416	7.872e-148	482.0	COG3119@1|root,COG3119@2|Bacteria,46U45@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_4878476_8	305900.GV64_19570	7.957e-136	447.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1XPAU@135619|Oceanospirillales	135619|Oceanospirillales	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_4878476_5	234267.Acid_2982	3.404e-277	892.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_2982|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878476_1	234267.Acid_7510	0.0	1373.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4878476_0	234267.Acid_6648	0.0	1580.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_6648|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878476_3	1267535.KB906767_gene5533	0.0	1242.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZU@57723|Acidobacteria,2JHPF@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_4878476_6	278963.ATWD01000001_gene2919	3.358e-176	597.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_4878476_2	234267.Acid_4967	0.0	1246.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y3SU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_4878476_10	240015.ACP_2197	1.091e-69	242.0	COG4567@1|root,COG4567@2|Bacteria	2|Bacteria	T	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain	regA	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
HFD1_k127_4878476_9	240015.ACP_2198	5.41e-129	426.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,HisKA_7TM
HFD1_k127_4878641_22	234267.Acid_5723	9.582e-28	115.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria	57723|Acidobacteria	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HFD1_k127_4878641_2	234267.Acid_5620	2.773e-222	696.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	DUF4214,Glycos_transf_2,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25
HFD1_k127_4878641_15	204669.Acid345_1832	5.798e-54	194.0	COG0780@1|root,COG0780@2|Bacteria,3Y4ND@57723|Acidobacteria,2JJ9J@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD1_k127_4878641_3	234267.Acid_5618	1.667e-216	676.0	COG1915@1|root,COG1915@2|Bacteria,3Y6MM@57723|Acidobacteria	57723|Acidobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HFD1_k127_4878641_25	204669.Acid345_2970	1.829e-21	109.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HFD1_k127_4878641_24	1408473.JHXO01000010_gene3623	2.165e-22	108.0	COG3301@1|root,COG3301@2|Bacteria,4NITJ@976|Bacteroidetes	976|Bacteroidetes	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD1_k127_4878641_14	1267535.KB906767_gene310	2.246e-61	233.0	COG3964@1|root,COG3964@2|Bacteria,3Y42F@57723|Acidobacteria	57723|Acidobacteria	S	amidohydrolase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_4878641_8	1408473.JHXO01000009_gene3488	1.698e-101	346.0	COG0667@1|root,COG0667@2|Bacteria,4P42C@976|Bacteroidetes	976|Bacteroidetes	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_4878641_20	983548.Krodi_2242	4.431e-42	163.0	COG2755@1|root,COG2755@2|Bacteria,4NMQM@976|Bacteroidetes,1I1P5@117743|Flavobacteriia,37FJJ@326319|Dokdonia	976|Bacteroidetes	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878641_10	1267535.KB906767_gene2293	1.034e-88	308.0	COG2230@1|root,COG2230@2|Bacteria,3Y5BV@57723|Acidobacteria,2JJVM@204432|Acidobacteriia	204432|Acidobacteriia	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD1_k127_4878641_6	234267.Acid_4738	1.048e-108	357.0	COG0500@1|root,COG2226@2|Bacteria,3Y5PC@57723|Acidobacteria	57723|Acidobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_4878641_1	234267.Acid_4739	1.013e-227	708.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD1_k127_4878641_19	234267.Acid_4789	8.497e-44	161.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria	57723|Acidobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD1_k127_4878641_16	234267.Acid_4790	6.149e-54	195.0	COG2825@1|root,COG2825@2|Bacteria,3Y8ID@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD1_k127_4878641_4	234267.Acid_4792	8.268e-205	641.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD1_k127_4878641_18	234267.Acid_4793	6.033e-46	168.0	2BYAI@1|root,315Y9@2|Bacteria,3Y52S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878641_23	1267535.KB906767_gene928	1.861e-22	112.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
HFD1_k127_4878641_5	234267.Acid_0678	2.157e-174	572.0	2DBYV@1|root,2ZBXC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878641_11	234267.Acid_0677	2.211e-86	313.0	2DBYV@1|root,2ZBXC@2|Bacteria	234267.Acid_0677|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878641_9	234267.Acid_0676	8.657e-90	315.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD1_k127_4878641_13	234267.Acid_0675	2.374e-73	248.0	2EB0S@1|root,3351M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4878641_12	1340493.JNIF01000004_gene222	5.689e-85	299.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	2|Bacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_4878641_7	1340493.JNIF01000003_gene3057	1.367e-102	342.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HFD1_k127_4878641_21	1125863.JAFN01000001_gene1323	3.351e-28	118.0	COG2402@1|root,COG2402@2|Bacteria,1NK19@1224|Proteobacteria,432DQ@68525|delta/epsilon subdivisions,2WY2Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_4878641_26	1330700.JQNC01000003_gene666	1.005e-16	82.0	2DSVR@1|root,33HKS@2|Bacteria,1WKIU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
HFD1_k127_4878641_0	234267.Acid_5929	0.0	1001.0	COG1964@1|root,COG1964@2|Bacteria	2|Bacteria	Q	Radical SAM superfamily	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_4878641_27	547144.HydHO_0914	5.735e-08	55.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_4879095_4	1173028.ANKO01000190_gene438	5.438e-20	91.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	2|Bacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,Haemagg_act,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
HFD1_k127_4879095_6	1173025.GEI7407_2596	4.825e-14	76.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_10,TPR_12,TPR_7,TPR_8
HFD1_k127_4879095_0	234267.Acid_7854	1.002e-257	801.0	COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD1_k127_4879095_2	1340493.JNIF01000003_gene3844	1.467e-109	403.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.62	ko:K01342,ko:K12287,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02044,ko03110	-	-	-	FG-GAP,Peptidase_S8,VCBS
HFD1_k127_4879095_1	1340493.JNIF01000003_gene3844	2.131e-117	428.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.62	ko:K01342,ko:K12287,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02044,ko03110	-	-	-	FG-GAP,Peptidase_S8,VCBS
HFD1_k127_4879095_3	344747.PM8797T_17237	3.879e-54	203.0	COG0657@1|root,COG0657@2|Bacteria,2IYY7@203682|Planctomycetes	203682|Planctomycetes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_4879095_5	234267.Acid_6336	2.353e-15	81.0	COG2017@1|root,COG2017@2|Bacteria,3Y6TJ@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4879095_7	1278073.MYSTI_03556	1.956e-08	58.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_4883081_8	234267.Acid_6547	1.541e-74	252.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD1_k127_4883081_0	234267.Acid_6548	7.927e-278	866.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_4883081_11	649638.Trad_1402	3.912e-20	96.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HFD1_k127_4883081_10	1304865.JAGF01000001_gene1579	3.402e-23	106.0	COG4283@1|root,COG4283@2|Bacteria,2IBEX@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1706)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1706
HFD1_k127_4883081_12	1408433.JHXV01000002_gene443	3.465e-15	87.0	COG0526@1|root,COG0526@2|Bacteria,4NS44@976|Bacteroidetes,1I3AY@117743|Flavobacteriia	976|Bacteroidetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF3738
HFD1_k127_4883081_7	1267534.KB906755_gene3904	2.297e-76	271.0	COG0729@1|root,COG0729@2|Bacteria	2|Bacteria	M	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HFD1_k127_4883081_4	204669.Acid345_4083	1.136e-118	416.0	COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,3Y7ZQ@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF2813)	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	DUF2813
HFD1_k127_4883081_2	204669.Acid345_4086	1.023e-144	473.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JMD3@204432|Acidobacteriia	204432|Acidobacteriia	H	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD1_k127_4883081_6	204669.Acid345_4084	3.997e-98	328.0	COG1611@1|root,COG1611@2|Bacteria,3Y7Y0@57723|Acidobacteria,2JN31@204432|Acidobacteriia	204432|Acidobacteriia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD1_k127_4883081_9	1121382.JQKG01000008_gene1033	1.776e-37	145.0	COG5478@1|root,COG5478@2|Bacteria	2|Bacteria	S	Small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HFD1_k127_4883081_1	234267.Acid_6565	1.208e-178	582.0	COG3386@1|root,COG3386@2|Bacteria,3Y6WN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4883081_5	234267.Acid_7533	5.806e-117	399.0	COG3622@1|root,COG3622@2|Bacteria,3Y5NQ@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_4883081_3	1242864.D187_000739	1.281e-119	401.0	COG1940@1|root,COG1940@2|Bacteria,1R7YN@1224|Proteobacteria,42QSZ@68525|delta/epsilon subdivisions,2WN50@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
HFD1_k127_4883081_13	234267.Acid_4342	1.351e-10	74.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
HFD1_k127_4890552_2	234267.Acid_3914	1.511e-237	744.0	COG2010@1|root,COG3386@1|root,COG2010@2|Bacteria,COG3386@2|Bacteria,3Y9A6@57723|Acidobacteria	2|Bacteria	C	PFAM SMP-30 Gluconolaconase	peaA	GO:0003674,GO:0003824,GO:0004341,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016051,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:1901576	1.4.9.1	ko:K08685,ko:K14274	ko00040,ko00680,ko01120,map00040,map00680,map01120	-	R00606,R02427	RC00189,RC00713	ko00000,ko00001,ko01000	-	-	-	Cu2_monoox_C,Cu2_monooxygen,Dehyd-heme_bind,Qn_am_d_aII,Qn_am_d_aIII,Qn_am_d_aIV,SGL
HFD1_k127_4890552_0	234267.Acid_6912	1.795e-312	964.0	COG4993@1|root,COG4993@2|Bacteria,3Y72Y@57723|Acidobacteria	57723|Acidobacteria	G	PQQ enzyme repeat	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ
HFD1_k127_4890552_6	234267.Acid_6910	8.574e-59	209.0	COG2010@1|root,COG2010@2|Bacteria,3Y7WV@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
HFD1_k127_4890552_3	234267.Acid_6909	6.911e-122	407.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	ctaC	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD1_k127_4890552_1	234267.Acid_6908	5.143e-298	927.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,COX3
HFD1_k127_4890552_5	234267.Acid_6907	1.51e-67	239.0	COG1845@1|root,COG1845@2|Bacteria,3Y8D6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase subunit III	-	-	-	-	-	-	-	-	-	-	-	-	COX3
HFD1_k127_4890552_4	234267.Acid_6905	5.993e-69	240.0	COG3336@1|root,COG3336@2|Bacteria,3Y6N7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
HFD1_k127_4896584_1	234267.Acid_5512	1.153e-141	452.0	COG0540@1|root,COG0540@2|Bacteria,3Y3KK@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD1_k127_4896584_2	234267.Acid_5511	5.686e-92	306.0	COG2065@1|root,COG2065@2|Bacteria,3Y2S1@57723|Acidobacteria	57723|Acidobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD1_k127_4896584_0	234267.Acid_5510	2.286e-203	653.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4896584_3	234267.Acid_6386	1.277e-76	260.0	COG2159@1|root,COG2159@2|Bacteria,3Y2PY@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_4897166_2	234267.Acid_0723	1.541e-124	402.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD1_k127_4897166_3	234267.Acid_0724	9.81e-107	359.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD1_k127_4897166_5	234267.Acid_0725	1.152e-80	286.0	COG1246@1|root,COG1246@2|Bacteria,3Y3WV@57723|Acidobacteria	57723|Acidobacteria	E	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HFD1_k127_4897166_1	234267.Acid_0726	3.115e-189	593.0	COG0303@1|root,COG0303@2|Bacteria,3Y6V2@57723|Acidobacteria	57723|Acidobacteria	H	'Molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4897166_6	234267.Acid_0727	1.723e-76	269.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yihX	GO:0003674,GO:0003824,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.10,3.1.3.104,3.8.1.2	ko:K01560,ko:K07025,ko:K20866,ko:K21063	ko00010,ko00361,ko00625,ko00740,ko01100,ko01110,ko01120,map00010,map00361,map00625,map00740,map01100,map01110,map01120	M00125	R00947,R05287,R07280	RC00017,RC00078,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
HFD1_k127_4897166_8	706587.Desti_0504	2.392e-53	196.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2MRTF@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HFD1_k127_4897166_0	234267.Acid_5465	0.0	1072.0	COG0577@1|root,COG0577@2|Bacteria,3Y6MX@57723|Acidobacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4897166_7	234267.Acid_6742	1.253e-75	260.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
HFD1_k127_4897166_4	234267.Acid_6743	2.131e-106	346.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD1_k127_491310_6	641524.ADICYQ_1427	2.991e-54	199.0	COG1520@1|root,COG1520@2|Bacteria,4NHU3@976|Bacteroidetes	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_491310_5	234267.Acid_4214	2.796e-71	244.0	2B6R1@1|root,31ZPU@2|Bacteria,3Y4VP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_491310_9	234267.Acid_4213	4.05e-29	124.0	2DG6A@1|root,2ZUQ0@2|Bacteria,3Y8Y2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_491310_11	1396141.BATP01000006_gene5422	4.162e-05	56.0	2EQPS@1|root,33I9Q@2|Bacteria,46X0R@74201|Verrucomicrobia,2IWFG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_491310_4	497964.CfE428DRAFT_0984	2.822e-73	267.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_491310_2	234267.Acid_2865	1.19e-102	340.0	COG1028@1|root,COG1028@2|Bacteria,3Y801@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_491310_0	234267.Acid_2864	5.578e-154	491.0	COG1940@1|root,COG1940@2|Bacteria,3Y7MC@57723|Acidobacteria	57723|Acidobacteria	GK	PFAM ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD1_k127_491310_10	234267.Acid_3794	4.325e-17	89.0	COG3266@1|root,COG3266@2|Bacteria,3Y4N4@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD1_k127_491310_1	1123242.JH636434_gene3999	5.954e-142	469.0	COG5337@1|root,COG5337@2|Bacteria,2IYR8@203682|Planctomycetes	203682|Planctomycetes	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
HFD1_k127_491310_8	1210884.HG799465_gene11330	1.297e-37	156.0	COG5036@1|root,COG5036@2|Bacteria,2J00S@203682|Planctomycetes	203682|Planctomycetes	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
HFD1_k127_491310_3	1267535.KB906767_gene4988	2.588e-86	296.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_4916811_3	234267.Acid_0593	1.321e-74	255.0	28JXN@1|root,30T38@2|Bacteria,3Y61P@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_4916811_0	234267.Acid_4489	1.323e-300	942.0	COG0577@1|root,COG0577@2|Bacteria,3Y34I@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4916811_1	234267.Acid_7119	2.378e-176	556.0	COG1216@1|root,COG1216@2|Bacteria,3Y7YU@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4916811_2	234267.Acid_7120	3.358e-111	378.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
HFD1_k127_4934754_0	204669.Acid345_1345	1.541e-73	276.0	COG1361@1|root,COG1572@1|root,COG3712@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	DUF11,FecR
HFD1_k127_4942038_3	234267.Acid_6256	8.309e-11	76.0	COG4447@1|root,COG4447@2|Bacteria,3Y9AF@57723|Acidobacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,SBBP,Sortilin-Vps10
HFD1_k127_4942038_1	1458462.JNLK01000001_gene773	3.919e-41	174.0	COG3391@1|root,COG5263@1|root,COG3391@2|Bacteria,COG5263@2|Bacteria,1UV67@1239|Firmicutes,24AV9@186801|Clostridia,27TEP@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Putative cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,Cadherin-like
HFD1_k127_4942038_0	234267.Acid_7188	0.0	1019.0	COG2844@1|root,COG2844@2|Bacteria,3Y2FJ@57723|Acidobacteria	57723|Acidobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD
HFD1_k127_4942038_2	234267.Acid_5534	3.535e-37	140.0	COG0347@1|root,COG0347@2|Bacteria,3Y4TF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD1_k127_4958057_0	234267.Acid_1552	0.0	1231.0	COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria	57723|Acidobacteria	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
HFD1_k127_4958057_1	450851.PHZ_c3358	2.842e-42	159.0	COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2TTZG@28211|Alphaproteobacteria,2KFNE@204458|Caulobacterales	204458|Caulobacterales	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
HFD1_k127_4966820_4	204669.Acid345_2137	1.524e-115	381.0	COG0240@1|root,COG0240@2|Bacteria,3Y3ZH@57723|Acidobacteria,2JINS@204432|Acidobacteriia	204432|Acidobacteriia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HFD1_k127_4966820_5	234267.Acid_0312	7.234e-104	340.0	COG1595@1|root,COG1595@2|Bacteria,3Y2V2@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_4966820_13	234267.Acid_0310	1.062e-13	81.0	2DZHS@1|root,32VB2@2|Bacteria,3Y54X@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HFD1_k127_4966820_3	639030.JHVA01000001_gene113	3.34e-152	492.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	2|Bacteria	E	PFAM Alcohol dehydrogenase	ydjL	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_4966820_6	909663.KI867150_gene2891	2.212e-84	289.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HFD1_k127_4966820_9	909663.KI867150_gene2890	2.183e-34	151.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,42PA3@68525|delta/epsilon subdivisions,2WM6X@28221|Deltaproteobacteria,2MQSC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HFD1_k127_4966820_11	204669.Acid345_3956	7.588e-30	128.0	COG2067@1|root,COG2067@2|Bacteria,3Y7IH@57723|Acidobacteria,2JMT6@204432|Acidobacteriia	204432|Acidobacteriia	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4966820_10	234267.Acid_3392	1.811e-30	131.0	2E74W@1|root,331P9@2|Bacteria,3Y8XR@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HFD1_k127_4966820_0	83332.Rv0663	0.0	1397.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,233CA@1762|Mycobacteriaceae	201174|Actinobacteria	P	thought to play an important role in the mineralization of sulfates catalytic activity a phenol sulfate H2O a phenol sulfate	atsD	GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_4966820_2	1532558.JL39_15410	2.059e-214	672.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2U0BU@28211|Alphaproteobacteria,4BHBC@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HFD1_k127_4966820_7	234267.Acid_0308	8.076e-59	205.0	COG3118@1|root,COG3118@2|Bacteria,3Y53D@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HFD1_k127_4966820_1	234267.Acid_0307	5.734e-237	739.0	COG0297@1|root,COG0297@2|Bacteria,3Y3IH@57723|Acidobacteria	57723|Acidobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD1_k127_4970126_0	234267.Acid_0453	4.072e-225	702.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HFD1_k127_4970126_10	876269.ARWA01000001_gene556	7.696e-25	106.0	COG4453@1|root,COG4453@2|Bacteria,1PW0Z@1224|Proteobacteria,2V2IT@28211|Alphaproteobacteria,3NCX9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
HFD1_k127_4970126_7	395492.Rleg2_2580	1.42e-47	179.0	COG0454@1|root,COG0456@2|Bacteria,1N009@1224|Proteobacteria,2U6PP@28211|Alphaproteobacteria,4BECS@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HFD1_k127_4970126_1	234267.Acid_0452	1.464e-216	677.0	COG0247@1|root,COG0247@2|Bacteria,3Y6NT@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
HFD1_k127_4970126_8	313612.L8106_20962	2.844e-40	168.0	COG0277@1|root,COG0277@2|Bacteria,1G176@1117|Cyanobacteria,1H7RA@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD linked oxidases, C-terminal domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD1_k127_4970126_13	317936.Nos7107_5345	5.346e-20	95.0	COG1950@1|root,COG1950@2|Bacteria,1G7RB@1117|Cyanobacteria,1HNVQ@1161|Nostocales	1117|Cyanobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HFD1_k127_4970126_3	234267.Acid_0449	7.76e-126	405.0	COG1801@1|root,COG1801@2|Bacteria,3Y2F1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD1_k127_4970126_11	760142.Hipma_0273	2.871e-22	102.0	28ISQ@1|root,33DSE@2|Bacteria,1NJUV@1224|Proteobacteria,42XI4@68525|delta/epsilon subdivisions,2WT4N@28221|Deltaproteobacteria,2M7FT@213113|Desulfurellales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4970126_12	1230457.C476_03743	4.259e-22	106.0	COG0589@1|root,arCOG00449@2157|Archaea,2XVPB@28890|Euryarchaeota,23SHQ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD1_k127_4970126_9	867903.ThesuDRAFT_02285	8.262e-32	141.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24IAZ@186801|Clostridia,3WD9X@538999|Clostridiales incertae sedis	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
HFD1_k127_4970126_4	391625.PPSIR1_07543	3.363e-118	396.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUB5@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_4970126_2	234267.Acid_7842	7.484e-147	473.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria	57723|Acidobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD1_k127_4970126_5	234267.Acid_7843	1.489e-113	370.0	COG1793@1|root,COG1793@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD1_k127_4970126_6	234267.Acid_7844	6.922e-97	323.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD1_k127_4974988_4	234267.Acid_3557	1.95e-109	362.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD1_k127_4974988_0	234267.Acid_7665	5.785e-244	769.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,PSCyt2,PSD1
HFD1_k127_4974988_2	234267.Acid_7666	1.282e-200	636.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_4974988_3	204669.Acid345_2910	9.548e-146	479.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_4974988_9	1267534.KB906759_gene1974	4.953e-25	108.0	COG2149@1|root,COG2149@2|Bacteria,3Y60S@57723|Acidobacteria,2JNN3@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HFD1_k127_4974988_11	644966.Tmar_2081	5.014e-06	58.0	COG3088@1|root,COG3088@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564	-	ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmH
HFD1_k127_4974988_1	1267535.KB906767_gene4235	1.314e-209	676.0	COG1506@1|root,COG1506@2|Bacteria,3Y6QI@57723|Acidobacteria	57723|Acidobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4974988_6	1123508.JH636439_gene1117	3.945e-71	252.0	COG3391@1|root,COG3391@2|Bacteria,2J2IQ@203682|Planctomycetes	203682|Planctomycetes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_4974988_5	1340493.JNIF01000003_gene4320	8.007e-83	280.0	COG1321@1|root,COG1321@2|Bacteria,3Y5SN@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HFD1_k127_4974988_8	1123368.AUIS01000015_gene2615	6.99e-60	225.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4974988_10	572544.Ilyop_2829	2.239e-10	73.0	COG1622@1|root,COG1622@2|Bacteria,37CJY@32066|Fusobacteria	32066|Fusobacteria	C	cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HFD1_k127_4974988_7	497964.CfE428DRAFT_0572	9.358e-69	251.0	COG3488@1|root,COG3488@2|Bacteria,46T3U@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HFD1_k127_4976550_4	103690.17135127	2.72e-24	106.0	COG3744@1|root,COG3744@2|Bacteria,1G8C0@1117|Cyanobacteria,1HP60@1161|Nostocales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_4976550_2	1122963.AUHB01000017_gene1992	5.963e-48	180.0	28MI1@1|root,2ZAUV@2|Bacteria,1R8Y2@1224|Proteobacteria,2UAC6@28211|Alphaproteobacteria,370TR@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HFD1_k127_4976550_5	1122963.AUHB01000017_gene1993	4.44e-21	98.0	2E8SU@1|root,3333K@2|Bacteria,1NBPV@1224|Proteobacteria,2UTF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4976550_1	234267.Acid_1315	9.434e-73	252.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_4976550_0	234267.Acid_2237	6.608e-94	312.0	COG0279@1|root,COG0279@2|Bacteria,3Y7D7@57723|Acidobacteria	57723|Acidobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD1_k127_4976550_3	1144275.COCOR_02589	2.838e-28	123.0	COG0382@1|root,COG0560@1|root,COG0382@2|Bacteria,COG0560@2|Bacteria,1MXCM@1224|Proteobacteria,42PWM@68525|delta/epsilon subdivisions,2WK8M@28221|Deltaproteobacteria,2YVRZ@29|Myxococcales	28221|Deltaproteobacteria	EH	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
HFD1_k127_4989959_3	192952.MM_3198	5.718e-63	237.0	COG1073@1|root,arCOG01661@2157|Archaea,2XVIC@28890|Euryarchaeota,2NANZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
HFD1_k127_4989959_1	234267.Acid_7667	3.51e-100	342.0	COG1310@1|root,COG1310@2|Bacteria,3Y8K0@57723|Acidobacteria	57723|Acidobacteria	S	metal-dependent protease of the Pad1 Jab1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4989959_2	234267.Acid_7668	1.008e-96	321.0	COG3605@1|root,COG3605@2|Bacteria,3Y7TF@57723|Acidobacteria	57723|Acidobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
HFD1_k127_4989959_0	234267.Acid_7669	2.641e-139	452.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
HFD1_k127_4991195_2	1210884.HG799469_gene14206	9.049e-19	89.0	COG2433@1|root,COG2433@2|Bacteria,2IYQC@203682|Planctomycetes	203682|Planctomycetes	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HFD1_k127_4991195_0	886293.Sinac_6252	5.445e-193	609.0	COG5433@1|root,COG5433@2|Bacteria,2J2DN@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HFD1_k127_4991195_1	886293.Sinac_1034	3.112e-24	105.0	COG1413@1|root,COG1413@2|Bacteria,2J193@203682|Planctomycetes	203682|Planctomycetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_4994685_9	1280954.HPO_10090	1.078e-06	52.0	COG0031@1|root,COG0031@2|Bacteria,1NQUE@1224|Proteobacteria,2UP98@28211|Alphaproteobacteria,43X1G@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Cysteine synthase cystathionine beta-synthase family protein	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_4994685_2	1267535.KB906767_gene1468	3.141e-269	852.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_4994685_7	1340493.JNIF01000004_gene944	4.652e-66	243.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_4994685_3	335543.Sfum_1456	1.301e-148	485.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HFD1_k127_4994685_1	794903.OPIT5_01690	0.0	1250.0	COG0841@1|root,COG0841@2|Bacteria,46SDN@74201|Verrucomicrobia,3KA30@414999|Opitutae	414999|Opitutae	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_4994685_5	335543.Sfum_1458	1.457e-122	407.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MR8F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD1_k127_4994685_4	234267.Acid_5196	5.754e-136	438.0	COG0500@1|root,COG2226@2|Bacteria,3Y4B3@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_4994685_6	1340493.JNIF01000004_gene606	1.806e-89	302.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_4994685_0	234267.Acid_5314	0.0	1422.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_4994685_8	234267.Acid_6986	9.301e-11	63.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
HFD1_k127_5001008_2	234267.Acid_0352	4.248e-35	137.0	COG1071@1|root,COG1071@2|Bacteria,3Y4M3@57723|Acidobacteria	57723|Acidobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD1_k127_5001008_0	234267.Acid_7775	3.163e-100	329.0	COG1595@1|root,COG1595@2|Bacteria,3Y7WY@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_5007715_0	278963.ATWD01000001_gene2919	2.182e-173	589.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5022354_22	1267535.KB906767_gene3264	1.238e-52	196.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD1_k127_5022354_14	1123020.AUIE01000020_gene1075	3.06e-129	420.0	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,1SBT6@1236|Gammaproteobacteria,1YJ09@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD1_k127_5022354_16	395961.Cyan7425_2695	1.023e-95	323.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD1_k127_5022354_28	1340493.JNIF01000003_gene1314	2.45e-26	118.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
HFD1_k127_5022354_11	1340493.JNIF01000003_gene1315	3.238e-138	445.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD1_k127_5022354_20	234267.Acid_3293	3.778e-68	240.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	yjoA	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HFD1_k127_5022354_25	234267.Acid_4787	9.426e-33	129.0	COG2331@1|root,COG2331@2|Bacteria,3Y5KN@57723|Acidobacteria	57723|Acidobacteria	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD1_k127_5022354_0	234267.Acid_4784	9.68e-236	739.0	COG0591@1|root,COG0591@2|Bacteria,3Y419@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD1_k127_5022354_1	234267.Acid_4783	2.366e-216	679.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_5022354_9	234267.Acid_4782	1.992e-142	464.0	COG0265@1|root,COG0265@2|Bacteria,3Y3HE@57723|Acidobacteria	57723|Acidobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_5022354_24	768670.Calni_0043	1.341e-38	154.0	COG0237@1|root,COG0237@2|Bacteria,2GFJM@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HFD1_k127_5022354_6	234267.Acid_4780	1.157e-155	495.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD1_k127_5022354_34	335543.Sfum_3733	1.595e-08	64.0	COG3420@1|root,COG3420@2|Bacteria,1P2RP@1224|Proteobacteria,431DH@68525|delta/epsilon subdivisions,2WWUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HFD1_k127_5022354_21	234267.Acid_7625	6.301e-63	222.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HFD1_k127_5022354_12	234267.Acid_1368	1.002e-135	464.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Guanylate_cyc,Pkinase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD1_k127_5022354_10	234267.Acid_5981	1.792e-141	469.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5022354_8	234267.Acid_5982	4.312e-148	481.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5022354_2	1120705.FG95_01094	2.173e-179	572.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2K155@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_5022354_17	309807.SRU_2450	1.506e-94	328.0	COG1785@1|root,COG1785@2|Bacteria,4NG3D@976|Bacteroidetes,1FIWB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
HFD1_k127_5022354_30	1267534.KB906758_gene2456	2.476e-22	106.0	COG2885@1|root,COG2885@2|Bacteria,3Y310@57723|Acidobacteria,2JI18@204432|Acidobacteriia	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5022354_18	926560.KE387027_gene263	6.584e-83	283.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HFD1_k127_5022354_3	869210.Marky_1927	2.09e-175	565.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD1_k127_5022354_19	234267.Acid_4393	2.835e-78	271.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5022354_31	1380390.JIAT01000012_gene3004	9.477e-20	101.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
HFD1_k127_5022354_7	234267.Acid_7193	1.331e-152	497.0	COG2234@1|root,COG2234@2|Bacteria,3Y53E@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_5022354_23	234267.Acid_6606	1.263e-40	153.0	2BXJ9@1|root,2ZNPM@2|Bacteria,3Y966@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5022354_5	234267.Acid_6605	8.606e-168	529.0	COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HFD1_k127_5022354_4	234267.Acid_6604	4.392e-173	552.0	COG1413@1|root,COG1413@2|Bacteria,3Y6AH@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_5022354_32	234267.Acid_6603	5.376e-12	66.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HFD1_k127_5029900_1	234267.Acid_6238	5.038e-36	139.0	COG1238@1|root,COG1238@2|Bacteria,3Y8FS@57723|Acidobacteria	57723|Acidobacteria	I	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5029900_0	234267.Acid_3757	7.487e-74	260.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086,ko:K06867,ko:K06886	-	-	-	-	ko00000,ko03021	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
HFD1_k127_5041251_4	234267.Acid_7748	1.026e-202	636.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,3Y44H@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
HFD1_k127_5041251_2	234267.Acid_7747	5.442e-242	752.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD1_k127_5041251_5	234267.Acid_7746	3.283e-152	488.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_5041251_7	234267.Acid_7745	2.376e-129	420.0	COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_5041251_6	1088721.NSU_4456	1.019e-136	445.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2TT3J@28211|Alphaproteobacteria,2K2M5@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4172)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4172,Fic
HFD1_k127_5041251_14	266265.Bxe_A0921	5.323e-28	116.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VUG3@28216|Betaproteobacteria,1K72W@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD1_k127_5041251_13	631362.Thi970DRAFT_04655	3.214e-29	119.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,1S9WR@1236|Gammaproteobacteria,1WYUT@135613|Chromatiales	135613|Chromatiales	S	PFAM Plasmid maintenance system killer	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HFD1_k127_5041251_0	234267.Acid_6470	0.0	1487.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria	57723|Acidobacteria	M	Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD1_k127_5041251_8	234267.Acid_6469	9.127e-68	240.0	COG2825@1|root,COG2825@2|Bacteria,3Y56P@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD1_k127_5041251_1	234267.Acid_6467	1.753e-296	917.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3Y3VV@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HFD1_k127_5041251_3	234267.Acid_6221	3.868e-227	715.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HFD1_k127_5041251_9	234267.Acid_1353	5.663e-53	195.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_1353|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5041251_11	234267.Acid_6648	1.508e-32	132.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_6648|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5059866_4	278963.ATWD01000001_gene2919	7.915e-24	111.0	COG1629@1|root,COG4771@2|Bacteria,3Y778@57723|Acidobacteria,2JKG8@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5059866_3	285535.JOEY01000015_gene4213	4.951e-96	325.0	COG3693@1|root,COG3693@2|Bacteria,2GJSN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 10	tomA	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_2,CBM_4_9,Glyco_hydro_10,Polysacc_deac_1
HFD1_k127_5059866_1	234267.Acid_2973	3.336e-141	454.0	COG0346@1|root,COG0346@2|Bacteria,3Y3QS@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD1_k127_5059866_0	234267.Acid_7696	0.0	1190.0	COG1166@1|root,COG1166@2|Bacteria,3Y449@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HFD1_k127_5059866_2	234267.Acid_1626	2.112e-111	364.0	2EPYW@1|root,33HJG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5063723_0	234267.Acid_7187	3.732e-142	463.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD1_k127_5066369_4	234267.Acid_7402	2.938e-82	273.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria	57723|Acidobacteria	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD1_k127_5066369_3	234267.Acid_7401	3.315e-100	332.0	2CAZH@1|root,2Z7RU@2|Bacteria,3Y4WA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HFD1_k127_5066369_9	682795.AciX8_1274	1.121e-22	102.0	COG4634@1|root,COG4634@2|Bacteria,3Y90A@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5066369_10	234267.Acid_6677	3.501e-19	89.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD1_k127_5066369_2	234267.Acid_6696	4.813e-126	406.0	COG0745@1|root,COG0745@2|Bacteria,3Y4GX@57723|Acidobacteria	57723|Acidobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_5066369_0	234267.Acid_6697	1e-223	705.0	COG1004@1|root,COG1004@2|Bacteria,3Y3GR@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD1_k127_5066369_5	234267.Acid_7534	3.698e-81	285.0	2E22I@1|root,32XA4@2|Bacteria,3Y54C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5066369_1	234267.Acid_7535	2.003e-145	467.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_5066369_6	105425.BBPL01000004_gene7619	2.908e-50	183.0	COG1764@1|root,COG1764@2|Bacteria,2IHT2@201174|Actinobacteria,2NJ1D@228398|Streptacidiphilus	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD1_k127_5066369_8	234267.Acid_6640	2.097e-33	133.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02584,ko:K07713,ko:K15836,ko:K21009	ko02020,ko02025,map02020,map02025	M00499	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	GAF,GAF_2,HTH_8,PocR,Sigma54_activat,Yop-YscD_cpl
HFD1_k127_5073287_0	234267.Acid_0131	6.026e-134	439.0	COG3103@1|root,COG3103@2|Bacteria,3Y3S0@57723|Acidobacteria	57723|Acidobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_8
HFD1_k127_5073287_1	234267.Acid_0130	3.401e-117	379.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_5086377_2	1159870.KB907784_gene1175	1.711e-60	211.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,3T1DN@506|Alcaligenaceae	28216|Betaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HFD1_k127_5086377_3	742821.HMPREF9464_01724	9.686e-48	173.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,4PR3Q@995019|Sutterellaceae	28216|Betaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD1_k127_5086377_0	1095769.CAHF01000003_gene1072	2.474e-74	254.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2VQ4W@28216|Betaproteobacteria,472EI@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HFD1_k127_5086377_1	1247649.D560_1442	8.86e-64	220.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,3T3SI@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HFD1_k127_5090879_3	234267.Acid_0873	1.924e-89	314.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_5090879_5	234267.Acid_0873	4.484e-75	256.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_5090879_1	204669.Acid345_3044	3.619e-134	435.0	COG1064@1|root,COG1064@2|Bacteria,3Y3X1@57723|Acidobacteria,2JJDF@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_5090879_7	401053.AciPR4_1472	6.655e-38	157.0	COG4219@1|root,COG4219@2|Bacteria,3Y6SV@57723|Acidobacteria,2JKBD@204432|Acidobacteriia	204432|Acidobacteriia	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_5090879_9	251221.35212995	3.06e-12	72.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5090879_6	234267.Acid_1039	3.003e-57	209.0	COG1648@1|root,COG1648@2|Bacteria,3Y4XH@57723|Acidobacteria	57723|Acidobacteria	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
HFD1_k127_5090879_0	234267.Acid_1038	1.786e-209	658.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria	57723|Acidobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD1_k127_5090879_4	234267.Acid_1037	2.279e-75	257.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD1_k127_5090879_2	234267.Acid_1036	1.008e-99	331.0	COG0500@1|root,COG0500@2|Bacteria,3Y5HU@57723|Acidobacteria	57723|Acidobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_509212_2	234267.Acid_6296	1.137e-77	261.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_509212_0	234267.Acid_1528	3.781e-214	678.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria	2|Bacteria	P	PFAM Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_509212_3	234267.Acid_3334	8.968e-66	241.0	COG3391@1|root,COG3391@2|Bacteria,3Y3R3@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD1_k127_509212_1	234267.Acid_2830	1.715e-93	313.0	COG2230@1|root,COG2230@2|Bacteria,3Y9AA@57723|Acidobacteria	57723|Acidobacteria	M	DREV methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_509212_4	234267.Acid_2828	1.589e-44	163.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria	57723|Acidobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD1_k127_5104299_10	1340493.JNIF01000003_gene2517	2.319e-77	287.0	COG1629@1|root,COG4771@2|Bacteria,3Y3NM@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5104299_6	1267535.KB906767_gene2603	9.905e-107	356.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,BNR_4
HFD1_k127_5104299_0	234267.Acid_3621	0.0	1649.0	COG1629@1|root,COG4771@2|Bacteria,3Y7FP@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5104299_12	768710.DesyoDRAFT_2386	2.916e-38	164.0	COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,24EBQ@186801|Clostridia,26413@186807|Peptococcaceae	186801|Clostridia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HFD1_k127_5104299_3	234267.Acid_0334	2.298e-273	857.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
HFD1_k127_5104299_7	234267.Acid_0159	4.714e-105	344.0	COG1707@1|root,COG1707@2|Bacteria,3Y6KK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	-
HFD1_k127_5104299_11	234267.Acid_0336	6.15e-60	216.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Y7@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5104299_8	234267.Acid_5633	1.318e-85	289.0	COG1238@1|root,COG1238@2|Bacteria,3Y5BJ@57723|Acidobacteria	57723|Acidobacteria	I	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD1_k127_5104299_9	1125863.JAFN01000001_gene2474	4.013e-81	281.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD1_k127_5104299_1	234267.Acid_1174	0.0	1277.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria	57723|Acidobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD1_k127_5104299_4	204669.Acid345_0046	5.128e-263	817.0	COG0531@1|root,COG0531@2|Bacteria,3Y2R3@57723|Acidobacteria,2JI6R@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_5104299_2	1340493.JNIF01000004_gene97	0.0	1146.0	COG1629@1|root,COG4771@2|Bacteria,3Y66T@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_5104299_5	234267.Acid_2010	4.737e-253	800.0	COG1629@1|root,COG4771@2|Bacteria,3Y66T@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_5107074_1	234267.Acid_6757	8.897e-233	729.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,3Y2KW@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HFD1_k127_5107074_3	234267.Acid_4687	3.868e-57	200.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5107074_0	234267.Acid_4688	0.0	1192.0	COG0577@1|root,COG0577@2|Bacteria,3Y73F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5107074_2	234267.Acid_3083	1.17e-118	387.0	COG3595@1|root,COG3595@2|Bacteria,3Y5AF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5107074_4	1230341.MJ3_09373	2.092e-13	72.0	COG0591@1|root,COG0591@2|Bacteria,1TXVZ@1239|Firmicutes,4HE4E@91061|Bacilli	91061|Bacilli	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14387	ko04725,ko05231,map04725,map05231	-	-	-	ko00000,ko00001,ko02000	2.A.21.8	-	-	SSF
HFD1_k127_511101_0	234267.Acid_2721	2.358e-43	164.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD1_k127_5124783_4	1463856.JOHY01000050_gene3071	0.0004408	52.0	COG2319@1|root,COG2319@2|Bacteria,2H7E3@201174|Actinobacteria	201174|Actinobacteria	S	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	WD40
HFD1_k127_5124783_1	1192034.CAP_2816	1.806e-33	150.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_5124783_0	313628.LNTAR_23894	4.811e-69	253.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5124783_3	883126.HMPREF9710_00818	3.527e-07	62.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
HFD1_k127_5124783_2	244582.JQAK01000015_gene2408	5.323e-10	64.0	COG1192@1|root,COG1192@2|Bacteria,1R5IJ@1224|Proteobacteria	1224|Proteobacteria	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5125376_2	234267.Acid_2122	1.011e-57	202.0	COG0524@1|root,COG0524@2|Bacteria,3Y6VV@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD1_k127_5125376_7	102129.Lepto7375DRAFT_7693	3.271e-40	149.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_5125376_10	1550091.JROE01000031_gene4214	6.127e-06	58.0	COG0346@1|root,COG0346@2|Bacteria,4NQIE@976|Bacteroidetes,1IT14@117747|Sphingobacteriia	976|Bacteroidetes	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_5125376_8	234267.Acid_4266	2.513e-23	110.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_5125376_1	1191523.MROS_0710	3.106e-81	283.0	COG0545@1|root,COG0652@1|root,COG2234@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	ppiC	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,FKBP_N,Peptidase_M28,Pro_isomerase
HFD1_k127_5125376_9	880070.Cycma_1176	1.942e-19	92.0	COG2267@1|root,COG2267@2|Bacteria,4PN9Y@976|Bacteroidetes,47NPH@768503|Cytophagia	976|Bacteroidetes	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD1_k127_5125376_4	1386089.N865_20905	1.183e-52	195.0	COG2267@1|root,COG2267@2|Bacteria,2HEX8@201174|Actinobacteria,4FIB8@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Glyco_tran_28_C
HFD1_k127_5125376_5	861299.J421_6124	5.479e-50	190.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HFD1_k127_5125376_6	1194972.MVAC_12718	1.014e-45	173.0	COG0662@1|root,COG0662@2|Bacteria,2I41N@201174|Actinobacteria,2380V@1762|Mycobacteriaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_5125376_0	404589.Anae109_1649	4.095e-150	492.0	COG0318@1|root,COG0318@2|Bacteria,1PW6W@1224|Proteobacteria,42PK0@68525|delta/epsilon subdivisions,2WMK6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD1_k127_5125376_3	234267.Acid_4844	1.376e-56	198.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HFD1_k127_5129674_1	234267.Acid_0207	1.994e-103	340.0	COG0583@1|root,COG0583@2|Bacteria,3Y34A@57723|Acidobacteria	57723|Acidobacteria	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD1_k127_5129674_2	1298593.TOL_0849	2.589e-17	87.0	COG1544@1|root,COG1544@2|Bacteria,1N8CQ@1224|Proteobacteria,1SE0D@1236|Gammaproteobacteria,1XPU0@135619|Oceanospirillales	135619|Oceanospirillales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
HFD1_k127_5129674_0	234267.Acid_7828	1.378e-245	767.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_5162161_0	1382359.JIAL01000001_gene1871	3.182e-83	305.0	COG1629@1|root,COG4771@2|Bacteria,3Y3P9@57723|Acidobacteria,2JHUB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_5163371_0	234267.Acid_3513	1.819e-153	499.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,3Y39H@57723|Acidobacteria	57723|Acidobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HFD1_k127_5163371_1	234267.Acid_3512	9.132e-147	475.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HFD1_k127_5163371_2	234267.Acid_3511	9.74e-37	146.0	COG2836@1|root,COG2836@2|Bacteria	2|Bacteria	K	Biogenesis protein	braZ	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2,Ferric_reduct
HFD1_k127_5171178_6	1198114.AciX9_0622	1.898e-12	68.0	COG4952@1|root,COG4952@2|Bacteria,3Y3J5@57723|Acidobacteria,2JIM4@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Xylose isomerase	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_5171178_2	234267.Acid_7237	3.778e-68	240.0	COG5551@1|root,COG5551@2|Bacteria,3Y7HB@57723|Acidobacteria	57723|Acidobacteria	S	Pfam:DUF2276	-	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas6
HFD1_k127_5171178_0	234267.Acid_6225	1.186e-122	402.0	COG2120@1|root,COG2120@2|Bacteria,3Y7FS@57723|Acidobacteria	57723|Acidobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_5171178_8	1449049.JONW01000013_gene4729	1.178e-05	51.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PFAM Response regulator receiver domain	mctR	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_5171178_5	366602.Caul_2480	3.963e-32	140.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2TVYD@28211|Alphaproteobacteria,2KJD9@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD1_k127_5171178_4	1054213.HMPREF9946_01379	2.015e-62	224.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,2JYMX@204441|Rhodospirillales	204441|Rhodospirillales	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_5171178_3	420324.KI911992_gene7741	2.57e-63	224.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,1JZCV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Response regulator receiver domain	mctR	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_5171178_1	404589.Anae109_0955	6.437e-110	361.0	COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,2YUSH@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
HFD1_k127_5177355_0	1380391.JIAS01000013_gene3828	2.656e-21	102.0	COG1595@1|root,COG1595@2|Bacteria,1RHRR@1224|Proteobacteria,2U9G0@28211|Alphaproteobacteria,2JS74@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_5177355_1	1869.MB27_20610	4.61e-16	84.0	COG4191@1|root,COG4191@2|Bacteria,2IF7B@201174|Actinobacteria	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HFD1_k127_5177355_2	1227500.C494_09645	3.637e-13	79.0	COG0697@1|root,arCOG00271@2157|Archaea,2XTNF@28890|Euryarchaeota,23U8T@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_5181357_1	234267.Acid_2410	1.167e-125	404.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_5181357_2	69395.JQLZ01000007_gene1773	8.513e-101	357.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWFB@28211|Alphaproteobacteria,2KFH9@204458|Caulobacterales	204458|Caulobacterales	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg
HFD1_k127_5181357_3	211165.AJLN01000088_gene2607	8.952e-22	109.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
HFD1_k127_5181357_0	234267.Acid_2773	3.254e-184	578.0	COG1082@1|root,COG1082@2|Bacteria,3Y3U5@57723|Acidobacteria	57723|Acidobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HFD1_k127_5188145_7	234267.Acid_0387	4.366e-37	162.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HFD1_k127_5188145_4	1132509.C447_11290	1.394e-102	356.0	COG3250@1|root,arCOG07337@2157|Archaea	2157|Archaea	G	COG3250 Beta-galactosidase beta-glucuronidase	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_5188145_6	926566.Terro_2954	2.092e-47	184.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	MA20_15070	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD1_k127_5188145_5	697282.Mettu_2865	2.157e-70	247.0	COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,1S6TJ@1236|Gammaproteobacteria,1XG6E@135618|Methylococcales	135618|Methylococcales	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD1_k127_5188145_1	215803.DB30_8460	1.404e-218	686.0	28KHV@1|root,2ZA39@2|Bacteria,1RDCS@1224|Proteobacteria,434ZZ@68525|delta/epsilon subdivisions,2WZAT@28221|Deltaproteobacteria,2Z1QU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5188145_0	215803.DB30_8461	0.0	1885.0	COG4630@1|root,COG4631@1|root,COG4630@2|Bacteria,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,43C3C@68525|delta/epsilon subdivisions,2X7DZ@28221|Deltaproteobacteria,2YWS9@29|Myxococcales	1224|Proteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4,1.17.3.2	ko:K00106,ko:K13482	ko00230,ko00232,ko00983,ko01100,ko01110,ko01120,ko04146,map00230,map00232,map00983,map01100,map01110,map01120,map04146	M00546	R01768,R01769,R02103,R02107,R07942,R07977,R07978,R07979,R08235	RC00143,RC02017,RC02199	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HFD1_k127_5188145_2	1267535.KB906767_gene3385	2.174e-116	391.0	28KHV@1|root,2ZA39@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5188145_3	1123237.Salmuc_02190	1.212e-115	384.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2U19S@28211|Alphaproteobacteria	1224|Proteobacteria	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HFD1_k127_5189154_2	234267.Acid_0730	1.488e-145	470.0	COG1538@1|root,COG1538@2|Bacteria,3Y3BF@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_5189154_7	1267535.KB906767_gene1370	1.788e-17	96.0	COG4932@1|root,COG4932@2|Bacteria,3Y7YN@57723|Acidobacteria,2JNHE@204432|Acidobacteriia	204432|Acidobacteriia	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5189154_3	234267.Acid_1525	4.123e-121	407.0	COG4932@1|root,COG4932@2|Bacteria,3Y53F@57723|Acidobacteria	57723|Acidobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5189154_0	234267.Acid_0732	4.664e-165	525.0	COG1420@1|root,COG1420@2|Bacteria,3Y2JI@57723|Acidobacteria	57723|Acidobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HFD1_k127_5189154_4	234267.Acid_0733	1.693e-62	219.0	COG0576@1|root,COG0576@2|Bacteria,3Y54K@57723|Acidobacteria	57723|Acidobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD1_k127_5189154_1	1340493.JNIF01000003_gene1999	4.729e-146	471.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD1_k127_5189154_8	1463820.JOGW01000007_gene1918	1.889e-17	88.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria	201174|Actinobacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_5189154_5	502025.Hoch_1576	2.3e-32	130.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_5195324_6	234267.Acid_0228	6.387e-109	369.0	COG2890@1|root,COG2890@2|Bacteria,3Y8Q3@57723|Acidobacteria	2|Bacteria	J	Pfam:Methyltransf_26	rsmC	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	MTS
HFD1_k127_5195324_8	234267.Acid_0231	1.2e-81	275.0	COG3516@1|root,COG3516@2|Bacteria,3Y4M4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP028301	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
HFD1_k127_5195324_2	234267.Acid_0232	6.85e-270	836.0	COG3517@1|root,COG3517@2|Bacteria,3Y2RM@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion protein, EvpB/VC_A0108, tail sheath	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
HFD1_k127_5195324_9	765911.Thivi_2288	6.855e-56	200.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,1S39K@1236|Gammaproteobacteria,1WYR2@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Type VI secretion system effector, Hcp1	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD1_k127_5195324_7	1267535.KB906767_gene2494	4.212e-85	288.0	COG4455@1|root,COG4455@2|Bacteria,3Y73H@57723|Acidobacteria	57723|Acidobacteria	S	ImpE protein	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
HFD1_k127_5195324_4	234267.Acid_0235	5.788e-207	670.0	COG3515@1|root,COG3515@2|Bacteria,3Y2NF@57723|Acidobacteria	57723|Acidobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N,T6SS_VasJ
HFD1_k127_5195324_11	1340493.JNIF01000004_gene589	2.271e-38	152.0	COG3518@1|root,COG3518@2|Bacteria	2|Bacteria	S	anti-sigma factor antagonist activity	impF	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
HFD1_k127_5195324_1	234267.Acid_0237	8.762e-294	912.0	COG3519@1|root,COG3519@2|Bacteria,3Y34T@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion system, TssF	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
HFD1_k127_5195324_5	234267.Acid_0238	7.712e-118	407.0	COG3520@1|root,COG3520@2|Bacteria,3Y49W@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion, TssG	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
HFD1_k127_5195324_0	330214.NIDE1985	0.0	1044.0	COG0542@1|root,COG0542@2|Bacteria,3J0W0@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small
HFD1_k127_5195324_3	886293.Sinac_2402	1.114e-252	805.0	COG3501@1|root,COG3501@2|Bacteria,2IWY7@203682|Planctomycetes	203682|Planctomycetes	Q	TIGRFAM type VI secretion system Vgr family protein	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
HFD1_k127_5195324_10	234267.Acid_0241	2.016e-52	190.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K11894	-	-	-	-	ko00000,ko02044	3.A.23.1	-	-	DUF3662,FHA
HFD1_k127_5205819_0	234267.Acid_4180	1.199e-285	889.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD1_k127_5205819_2	234267.Acid_5150	3.115e-49	181.0	COG2703@1|root,COG2703@2|Bacteria	2|Bacteria	P	oxygen carrier activity	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HFD1_k127_5205819_3	1230343.CANP01000005_gene502	1.043e-32	139.0	28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,1RY8I@1236|Gammaproteobacteria,1JGK3@118969|Legionellales	118969|Legionellales	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HFD1_k127_5205819_1	234267.Acid_3813	1.489e-64	226.0	2CM1I@1|root,32SDF@2|Bacteria,3Y571@57723|Acidobacteria	57723|Acidobacteria	S	shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD1_k127_5213463_1	1340493.JNIF01000004_gene277	2.772e-136	437.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_5213463_0	1340493.JNIF01000004_gene278	0.0	1066.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,PD40,PSCyt1,PSCyt2,PSD1,WD40
HFD1_k127_5213463_2	1340493.JNIF01000004_gene279	1.014e-31	132.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TIR_2,WD40
HFD1_k127_5221736_2	1267535.KB906767_gene5500	9.808e-27	120.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5221736_0	234267.Acid_4272	2.55e-225	711.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5221736_1	714943.Mucpa_7131	1.638e-35	139.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
HFD1_k127_5249656_0	292415.Tbd_2477	5.065e-258	797.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
HFD1_k127_5249656_1	292415.Tbd_2478	1.682e-51	182.0	COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,2VNTI@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD1_k127_5256830_13	234267.Acid_6186	8.266e-80	269.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD1_k127_5256830_1	234267.Acid_6187	9.384e-256	796.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_5256830_10	234267.Acid_2816	3.6e-108	358.0	COG2273@1|root,COG3693@1|root,COG2273@2|Bacteria,COG3693@2|Bacteria,3Y4BI@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
HFD1_k127_5256830_11	234267.Acid_2366	1.961e-90	303.0	COG0789@1|root,COG0789@2|Bacteria,3Y4XP@57723|Acidobacteria	57723|Acidobacteria	K	TipAS antibiotic-recognition domain	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HFD1_k127_5256830_7	234267.Acid_2127	1.661e-112	372.0	COG4447@1|root,COG4447@2|Bacteria,3Y2XZ@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5256830_0	1267535.KB906767_gene437	8.031e-262	831.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5256830_6	1123508.JH636439_gene1391	3.418e-121	423.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_5256830_4	234267.Acid_6178	1.891e-159	507.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	ytfQ	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD1_k127_5256830_5	234267.Acid_6177	5.947e-141	454.0	COG1172@1|root,COG1172@2|Bacteria,3Y5DG@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD1_k127_5256830_3	234267.Acid_6176	3.406e-175	571.0	COG1129@1|root,COG1129@2|Bacteria,3Y3UY@57723|Acidobacteria	57723|Acidobacteria	P	ABC transporter	-	-	3.6.3.17	ko:K10441,ko:K10545,ko:K10562	ko02010,map02010	M00212,M00215,M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.9	-	-	ABC_tran
HFD1_k127_5256830_12	1499967.BAYZ01000194_gene3127	5.603e-80	274.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD1_k127_5256830_15	1267534.KB906759_gene1703	1.806e-39	160.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5256830_2	234267.Acid_5001	8.404e-230	718.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HFD1_k127_5256830_14	234267.Acid_0951	6.264e-71	252.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0951|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5256830_9	401053.AciPR4_1096	4.364e-109	379.0	COG0823@1|root,COG0823@2|Bacteria,3Y4FU@57723|Acidobacteria,2JJ6C@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM WD40-like beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_5256830_8	1267535.KB906767_gene1797	1.802e-111	366.0	COG1735@1|root,COG1735@2|Bacteria,3Y646@57723|Acidobacteria,2JM01@204432|Acidobacteriia	204432|Acidobacteriia	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5256830_16	1458357.BG58_31745	2.976e-26	124.0	COG1305@1|root,COG1305@2|Bacteria,1RD7A@1224|Proteobacteria	1224|Proteobacteria	E	Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5264127_0	234267.Acid_6208	1.824e-283	880.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
HFD1_k127_5264127_2	234267.Acid_6209	8.548e-71	247.0	COG0723@1|root,COG0723@2|Bacteria,3Y7YJ@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD1_k127_5264127_3	234267.Acid_6210	2.747e-58	206.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD1_k127_5264127_4	234267.Acid_6093	5.477e-38	160.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD1_k127_5264127_1	234267.Acid_6092	1.814e-114	385.0	COG1574@1|root,COG1574@2|Bacteria,3Y7EK@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD1_k127_5265642_0	278963.ATWD01000001_gene1304	2.249e-307	970.0	COG1629@1|root,COG4771@2|Bacteria,3Y477@57723|Acidobacteria,2JHX2@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5265642_4	886293.Sinac_3180	4.484e-43	182.0	COG0671@1|root,COG0671@2|Bacteria,2J3BG@203682|Planctomycetes	203682|Planctomycetes	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5265642_3	234267.Acid_1819	1.117e-116	398.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5265642_1	314230.DSM3645_18481	1.754e-135	448.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5265642_2	471854.Dfer_1708	1.289e-134	452.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,47MWY@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
HFD1_k127_5277943_1	234267.Acid_5952	9.331e-136	464.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_5277943_0	234267.Acid_3075	2.342e-226	710.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD1_k127_5277943_2	1122222.AXWR01000001_gene1946	4.495e-100	334.0	COG2120@1|root,COG2120@2|Bacteria,1WIK2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	GlcNAc-PI de-N-acetylase	-	-	4.2.1.83	ko:K16515	ko00362,map00362	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	PIG-L
HFD1_k127_5277943_3	94624.Bpet3605	3.799e-81	276.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VICR@28216|Betaproteobacteria	28216|Betaproteobacteria	H	4-carboxy-4-hydroxy-2-oxoadipate aldolase oxaloacetate decarboxylase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HFD1_k127_5277943_5	1123072.AUDH01000005_gene1540	0.000449	46.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,2JTAE@204441|Rhodospirillales	204441|Rhodospirillales	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
HFD1_k127_5277943_4	1231391.AMZF01000009_gene1782	6.471e-13	73.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,3T4CS@506|Alcaligenaceae	28216|Betaproteobacteria	I	Domain of unknown function (DUF1932)	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	DUF1932,NAD_binding_2
HFD1_k127_5278161_1	234267.Acid_0215	4.674e-85	284.0	COG3118@1|root,COG3118@2|Bacteria,3Y99P@57723|Acidobacteria	57723|Acidobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD1_k127_5278161_0	251221.35211765	6.966e-148	496.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5284124_2	234267.Acid_2416	6.304e-50	179.0	COG4287@1|root,COG4287@2|Bacteria	2|Bacteria	S	PhoPQ-activated pathogenicity-related protein	pqaA	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
HFD1_k127_5284124_3	1210884.HG799465_gene11730	3.077e-45	180.0	COG0657@1|root,COG0657@2|Bacteria,2IXWJ@203682|Planctomycetes	203682|Planctomycetes	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_5284124_6	497964.CfE428DRAFT_5221	1.917e-07	56.0	COG2402@1|root,COG2402@2|Bacteria,46WKX@74201|Verrucomicrobia	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_5284124_4	1173022.Cri9333_3360	6.001e-21	100.0	COG2402@1|root,COG2402@2|Bacteria,1G79E@1117|Cyanobacteria,1HBMU@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_5284124_7	391612.CY0110_31975	2.358e-05	49.0	28ZU8@1|root,2ZMIX@2|Bacteria,1GG6Z@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5284124_1	204669.Acid345_3942	6.799e-87	293.0	COG4117@1|root,COG4117@2|Bacteria,3Y4KG@57723|Acidobacteria,2JJC0@204432|Acidobacteriia	204432|Acidobacteriia	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD1_k127_5284124_0	1267533.KB906735_gene4583	1.315e-106	364.0	COG2041@1|root,COG2041@2|Bacteria,3Y3AI@57723|Acidobacteria,2JHW2@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD1_k127_5284124_5	234267.Acid_3228	6.631e-14	82.0	2D4D1@1|root,32TGT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5292430_0	234267.Acid_4962	3.055e-114	376.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_5292430_1	234267.Acid_4961	2.627e-64	235.0	COG2110@1|root,COG2110@2|Bacteria,3Y4Y6@57723|Acidobacteria	57723|Acidobacteria	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HFD1_k127_5298428_4	234267.Acid_7419	3.703e-83	297.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria	57723|Acidobacteria	S	nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HFD1_k127_5298428_1	234267.Acid_7420	1.486e-142	463.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HFD1_k127_5298428_0	1449126.JQKL01000009_gene318	3.038e-246	800.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD1_k127_5298428_8	340177.Cag_0958	0.0002646	50.0	2DMZP@1|root,32UMQ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
HFD1_k127_5298428_6	1449126.JQKL01000002_gene1553	1.166e-19	102.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HFD1_k127_5298428_3	1265505.ATUG01000002_gene1615	3.985e-104	358.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD1_k127_5298428_7	941449.dsx2_2962	1.475e-08	67.0	2BJV9@1|root,32E7H@2|Bacteria,1QTNM@1224|Proteobacteria,43ETJ@68525|delta/epsilon subdivisions,2X1Q8@28221|Deltaproteobacteria,2MFGB@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5298428_2	1121396.KB893012_gene4039	2.679e-131	432.0	COG1148@1|root,COG1148@2|Bacteria,1R99M@1224|Proteobacteria,42Q2T@68525|delta/epsilon subdivisions,2WJTB@28221|Deltaproteobacteria,2MMH6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
HFD1_k127_5298428_5	1379698.RBG1_1C00001G0047	1.141e-19	89.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HFD1_k127_5301086_14	234267.Acid_6997	1.833e-06	53.0	COG3034@1|root,COG3034@2|Bacteria,3Y5ET@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD1_k127_5301086_6	234267.Acid_2361	3.058e-61	222.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_5301086_0	234267.Acid_6996	0.0	2076.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HFD1_k127_5301086_2	234267.Acid_6995	1.027e-177	563.0	COG0167@1|root,COG0167@2|Bacteria,3Y464@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD1_k127_5301086_12	745411.B3C1_18527	7.305e-07	54.0	2APBA@1|root,31EDH@2|Bacteria,1RIDJ@1224|Proteobacteria,1S6VZ@1236|Gammaproteobacteria,1J6M1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HFD1_k127_5301086_1	234267.Acid_5393	3.885e-222	712.0	COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria	57723|Acidobacteria	L	AAA ATPase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HFD1_k127_5301086_4	234267.Acid_5394	2.522e-86	292.0	COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD1_k127_5301086_5	234267.Acid_5395	3.75e-83	280.0	COG1434@1|root,COG1434@2|Bacteria,3Y4FT@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD1_k127_5301086_11	1267535.KB906767_gene4761	2.471e-14	85.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_5301086_9	234267.Acid_4719	1.745e-31	130.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD1_k127_5301086_10	234267.Acid_5187	1.053e-25	118.0	COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5301086_8	378806.STAUR_0350	2.954e-32	128.0	COG0640@1|root,COG0640@2|Bacteria,1N0DJ@1224|Proteobacteria,4382M@68525|delta/epsilon subdivisions,2X3CP@28221|Deltaproteobacteria,2YVFV@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_5301086_7	388051.AUFE01000021_gene148	1.701e-40	154.0	COG3832@1|root,COG3832@2|Bacteria,1RF9V@1224|Proteobacteria,2W2D0@28216|Betaproteobacteria,1KGAT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_5301086_15	1382359.JIAL01000001_gene2631	3.224e-05	56.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD1_k127_5301086_3	1267535.KB906767_gene335	2.788e-87	288.0	COG3508@1|root,COG3508@2|Bacteria,3Y38R@57723|Acidobacteria	57723|Acidobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HFD1_k127_5329190_0	1267535.KB906767_gene4218	9.302e-311	964.0	COG4354@1|root,COG4354@2|Bacteria,3Y2ZY@57723|Acidobacteria,2JHZE@204432|Acidobacteriia	204432|Acidobacteriia	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
HFD1_k127_5329190_4	1267535.KB906767_gene4217	4.901e-90	308.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HFD1_k127_5329190_3	234267.Acid_5960	1.179e-106	351.0	COG0748@1|root,COG0748@2|Bacteria,3Y2Q3@57723|Acidobacteria	57723|Acidobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Pyrid_oxidase_2
HFD1_k127_5329190_5	234267.Acid_4309	1.341e-29	136.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_4309|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5329190_2	530564.Psta_2567	1.716e-133	432.0	COG3828@1|root,COG3828@2|Bacteria,2IY8Q@203682|Planctomycetes	203682|Planctomycetes	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HFD1_k127_5329190_1	234267.Acid_0092	8.219e-161	521.0	COG2272@1|root,COG2272@2|Bacteria,3Y2GS@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_5329190_6	1123242.JH636435_gene2636	5.261e-06	53.0	COG0526@1|root,COG2373@1|root,COG4219@1|root,COG0526@2|Bacteria,COG2373@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K02172,ko:K06196	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504,ko02000	5.A.1.2	-	-	AhpC-TSA,CarboxypepD_reg,DsbD,Peptidase_M56
HFD1_k127_5335830_5	1267535.KB906767_gene5107	5.12e-10	64.0	COG0577@1|root,COG0577@2|Bacteria,3Y76A@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5335830_3	401053.AciPR4_1449	1.093e-38	150.0	COG1695@1|root,COG1695@2|Bacteria,3Y52Q@57723|Acidobacteria,2JMZJ@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5335830_1	1232410.KI421426_gene1474	4.279e-161	540.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,43DHA@68525|delta/epsilon subdivisions,2X8P3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD1_k127_5335830_0	234267.Acid_2315	0.0	1193.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_5335830_2	234267.Acid_5420	7.441e-120	395.0	COG1752@1|root,COG1752@2|Bacteria,3Y5EY@57723|Acidobacteria	57723|Acidobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD1_k127_5335830_4	234267.Acid_5318	9.717e-21	91.0	COG0377@1|root,COG0377@2|Bacteria,3Y475@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD1_k127_5358807_9	234267.Acid_4390	2.367e-13	70.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_5358807_1	234267.Acid_2187	4.106e-201	632.0	COG0019@1|root,COG0019@2|Bacteria,3Y2W4@57723|Acidobacteria	57723|Acidobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD1_k127_5358807_7	234267.Acid_5215	1.745e-59	207.0	COG1695@1|root,COG1695@2|Bacteria,3Y7WK@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5358807_2	251221.35211765	3.806e-174	576.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5358807_5	234267.Acid_4452	2.916e-115	381.0	COG1082@1|root,COG1082@2|Bacteria,3Y7D1@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_5358807_0	234267.Acid_4453	2.358e-211	681.0	COG4948@1|root,COG4948@2|Bacteria,3Y6X2@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5358807_6	234267.Acid_2822	8.64e-61	218.0	28J3W@1|root,2Z900@2|Bacteria,3Y47Q@57723|Acidobacteria	57723|Acidobacteria	S	pfam nipsnap	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD1_k127_5358807_8	234267.Acid_1213	2.504e-51	184.0	COG2127@1|root,COG2127@2|Bacteria,3Y85A@57723|Acidobacteria	57723|Acidobacteria	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD1_k127_5358807_3	234267.Acid_1215	2.541e-150	486.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria	57723|Acidobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_5376886_1	234267.Acid_3796	3.986e-117	390.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HFD1_k127_5376886_0	234267.Acid_4413	1.314e-215	673.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD1_k127_5376886_4	234267.Acid_4413	4.349e-23	98.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD1_k127_5376886_3	234267.Acid_4414	1.149e-30	126.0	COG1872@1|root,COG1872@2|Bacteria,3Y5S4@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HFD1_k127_5376886_2	118166.JH976537_gene1884	2.407e-70	270.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HFD1_k127_5380162_3	234267.Acid_7331	3.731e-84	282.0	COG0470@1|root,COG0470@2|Bacteria,3Y6V7@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HFD1_k127_5380162_0	234267.Acid_7333	9.938e-214	669.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD1_k127_5380162_4	234267.Acid_0091	2.042e-47	179.0	COG4233@1|root,COG4233@2|Bacteria	2|Bacteria	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HFD1_k127_5380162_1	234267.Acid_0090	1.521e-167	542.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	msrA	-	1.1.98.6,1.8.1.9,1.8.4.11,1.8.4.12	ko:K00384,ko:K12057,ko:K12267,ko:K21636	ko00230,ko00240,ko00450,ko01100,map00230,map00240,map00450,map01100	M00053	R02016,R03596,R09372,R11633,R11634,R11635,R11636	RC00013,RC00613,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.7.11.1	-	-	AhpC-TSA,PMSR,Pyr_redox_2,SelR,Thioredoxin,Thioredoxin_3,Thioredoxin_7,TraF
HFD1_k127_5380162_2	234267.Acid_0088	7.499e-130	436.0	COG2086@1|root,COG2086@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD1_k127_5388037_3	234267.Acid_4418	1.785e-147	471.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5388037_2	234267.Acid_4419	4.129e-161	517.0	COG5616@1|root,COG5616@2|Bacteria,3Y9AR@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5388037_0	234267.Acid_4421	1.445e-201	650.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HFD1_k127_5388037_1	234267.Acid_5055	2.141e-184	587.0	COG0477@1|root,COG2814@2|Bacteria,3Y2T2@57723|Acidobacteria	57723|Acidobacteria	EGP	Nucleoside H+ symporter	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_H_symport
HFD1_k127_5388037_5	401053.AciPR4_0674	3.763e-36	141.0	COG0454@1|root,COG0454@2|Bacteria,3Y7TA@57723|Acidobacteria,2JN0X@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5388037_4	234267.Acid_4171	7.896e-59	215.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_5388037_6	234267.Acid_5173	3.661e-34	132.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase A domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
HFD1_k127_5396075_1	234267.Acid_6621	1.699e-94	338.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1	-	-	NTP_transf_5,Poly_export,SLBB
HFD1_k127_5396075_0	1267535.KB906767_gene942	2.331e-151	520.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_5396075_2	234267.Acid_6633	3.357e-83	286.0	COG1493@1|root,COG1493@2|Bacteria,3Y4YI@57723|Acidobacteria	57723|Acidobacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5396075_3	234267.Acid_6634	2.303e-48	177.0	COG0438@1|root,COG0438@2|Bacteria,3Y647@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_5420433_2	234267.Acid_4576	1.309e-94	317.0	COG2010@1|root,COG2010@2|Bacteria,3Y846@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_5420433_0	234267.Acid_4577	3.103e-291	903.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_5420433_1	234267.Acid_2282	7.316e-258	800.0	COG1228@1|root,COG1228@2|Bacteria,3Y3PQ@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_5420433_4	1191523.MROS_0031	1.275e-05	47.0	COG4146@1|root,COG4146@2|Bacteria	2|Bacteria	S	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HFD1_k127_5426324_1	234267.Acid_3413	1.1e-90	304.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_5426324_0	234267.Acid_3414	1.515e-275	867.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria	57723|Acidobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
HFD1_k127_5426324_4	443144.GM21_1812	2.159e-20	97.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,43T3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HFD1_k127_5426324_3	234267.Acid_3415	9.757e-29	121.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,DUF2637,Peptidase_M56,TonB_C
HFD1_k127_5426324_2	234267.Acid_3416	4.863e-85	290.0	COG0840@1|root,COG0840@2|Bacteria,3Y4VY@57723|Acidobacteria	57723|Acidobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
HFD1_k127_5456043_11	234267.Acid_1489	3.316e-11	67.0	COG0501@1|root,COG0501@2|Bacteria,3Y8SC@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the peptidase M48B family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5456043_8	234267.Acid_1488	5.4e-47	171.0	COG3682@1|root,COG3682@2|Bacteria,3Y8QA@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_5456043_10	1123242.JH636436_gene220	8.286e-20	94.0	COG3541@1|root,COG3541@2|Bacteria,2IXJ3@203682|Planctomycetes	203682|Planctomycetes	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
HFD1_k127_5456043_6	234267.Acid_0369	6.283e-90	298.0	COG1595@1|root,COG1595@2|Bacteria,3Y7JF@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, luxR family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_5456043_7	234267.Acid_0370	3.486e-53	194.0	2C5RD@1|root,2ZUCI@2|Bacteria,3Y91D@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5456043_2	234267.Acid_0371	2.536e-148	478.0	2C5RF@1|root,33T7W@2|Bacteria,3Y6IQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5456043_9	1340493.JNIF01000004_gene125	6.963e-42	156.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5456043_1	234267.Acid_7551	7.738e-198	645.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5456043_0	234267.Acid_0372	1.462e-216	682.0	COG3104@1|root,COG3104@2|Bacteria,3Y6W5@57723|Acidobacteria	57723|Acidobacteria	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD1_k127_5456043_5	1267535.KB906767_gene3318	1.03e-110	372.0	COG0665@1|root,COG0665@2|Bacteria,3Y6FK@57723|Acidobacteria,2JKN4@204432|Acidobacteriia	204432|Acidobacteriia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD1_k127_5456043_3	234267.Acid_0376	2.886e-141	455.0	COG0454@1|root,COG0456@2|Bacteria,3Y3VJ@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_5456043_4	1382359.JIAL01000001_gene1413	2.17e-125	415.0	COG3250@1|root,COG3250@2|Bacteria,3Y4HP@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Glycoside hydrolase, family 2	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_5462500_6	404589.Anae109_3227	0.0002207	45.0	COG4420@1|root,COG4420@2|Bacteria,1RHHI@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HFD1_k127_5462500_4	237727.NAP1_11743	1.434e-27	114.0	COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,2UFAM@28211|Alphaproteobacteria,2KD9Y@204457|Sphingomonadales	204457|Sphingomonadales	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HFD1_k127_5462500_3	861299.J421_5889	1.9e-30	127.0	2DSP1@1|root,33GVU@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
HFD1_k127_5462500_2	626887.J057_08421	6.78e-33	140.0	COG0739@1|root,COG0739@2|Bacteria,1MXH6@1224|Proteobacteria,1SB0F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,UT
HFD1_k127_5462500_1	1961.JOAK01000005_gene24	3.03e-99	334.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD1_k127_5462500_0	1234364.AMSF01000079_gene1847	3.527e-181	586.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_5462707_11	472759.Nhal_2145	4.376e-25	109.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,1S4FS@1236|Gammaproteobacteria,1WYS2@135613|Chromatiales	135613|Chromatiales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HFD1_k127_5462707_14	68260.JOAY01000014_gene2726	4.031e-06	55.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
HFD1_k127_5462707_0	234267.Acid_1502	5.633e-217	698.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD1_k127_5462707_2	234267.Acid_1501	5.218e-162	515.0	COG0320@1|root,COG0320@2|Bacteria,3Y6DY@57723|Acidobacteria	57723|Acidobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HFD1_k127_5462707_3	234267.Acid_1499	1.092e-125	406.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD1_k127_5462707_1	234267.Acid_1498	1.487e-182	580.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria	57723|Acidobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HFD1_k127_5462707_13	234267.Acid_1497	2.363e-14	78.0	2DF57@1|root,2ZQIC@2|Bacteria,3Y8V0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
HFD1_k127_5462707_5	234267.Acid_1496	8.855e-105	343.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria	57723|Acidobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD1_k127_5462707_9	762984.HMPREF9445_01761	2.754e-52	210.0	COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia,4ANKU@815|Bacteroidaceae	976|Bacteroidetes	S	candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
HFD1_k127_5462707_12	1131269.AQVV01000025_gene2327	5.942e-23	115.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,HTH_31
HFD1_k127_5462707_6	1123508.JH636443_gene4957	3.848e-99	342.0	COG3356@1|root,COG3356@2|Bacteria,2IXX5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
HFD1_k127_5462707_8	234267.Acid_4014	1.223e-61	228.0	COG0673@1|root,COG0673@2|Bacteria,3Y4KS@57723|Acidobacteria	2|Bacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_5462707_4	234267.Acid_7405	1.716e-114	374.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	mmsB	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD1_k127_5462707_7	1340493.JNIF01000003_gene4368	1.439e-65	231.0	COG1629@1|root,COG4771@2|Bacteria,3Y9AT@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_5466478_6	234267.Acid_3183	7.966e-94	309.0	COG2316@1|root,COG2316@2|Bacteria,3Y4GI@57723|Acidobacteria	57723|Acidobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HFD1_k127_5466478_7	234267.Acid_4434	3.768e-80	282.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD1_k127_5466478_10	234267.Acid_4273	8.458e-45	165.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_5466478_12	1267535.KB906767_gene509	7.092e-22	100.0	COG1308@1|root,COG1308@2|Bacteria,3Y60R@57723|Acidobacteria	57723|Acidobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HFD1_k127_5466478_0	234267.Acid_4291	3.748e-265	838.0	COG0642@1|root,COG2199@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,3Y9AN@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_5466478_8	404589.Anae109_1512	2.381e-63	228.0	2CFSQ@1|root,32S2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5466478_5	1267535.KB906767_gene4437	6.885e-122	402.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HFD1_k127_5466478_1	1267535.KB906767_gene3771	1.075e-171	552.0	COG3119@1|root,COG3119@2|Bacteria,3Y3PF@57723|Acidobacteria,2JIZB@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_5466478_4	886293.Sinac_0926	2.043e-129	430.0	COG3119@1|root,COG3119@2|Bacteria,2IXG7@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
HFD1_k127_5466478_9	648757.Rvan_3534	1.061e-46	174.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,3N7FE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HFD1_k127_5466478_3	234267.Acid_4410	2.049e-132	433.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HFD1_k127_5466478_2	234267.Acid_4409	2.875e-163	537.0	COG0798@1|root,COG0798@2|Bacteria,3Y69M@57723|Acidobacteria	57723|Acidobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD1_k127_5466478_11	234267.Acid_4408	3.848e-43	178.0	COG0394@1|root,COG0394@2|Bacteria,3Y5NY@57723|Acidobacteria	57723|Acidobacteria	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HFD1_k127_5471048_1	234267.Acid_7817	2.381e-36	145.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	-
HFD1_k127_5471048_0	234267.Acid_7817	0.0	1304.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	-
HFD1_k127_5475448_3	671143.DAMO_2498	2.1e-125	419.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_5475448_5	1123392.AQWL01000007_gene873	3.352e-44	179.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,1KS3P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HFD1_k127_5475448_6	1267535.KB906767_gene2260	3.61e-19	93.0	COG3584@1|root,COG3584@2|Bacteria,3Y8W5@57723|Acidobacteria	57723|Acidobacteria	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
HFD1_k127_5475448_4	1267535.KB906767_gene1648	6.976e-59	206.0	COG5646@1|root,COG5646@2|Bacteria,3Y5GZ@57723|Acidobacteria,2JNWJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_5475448_1	234267.Acid_6196	6.762e-300	959.0	COG1629@1|root,COG4774@1|root,COG4771@2|Bacteria,COG4774@2|Bacteria,3Y3WR@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_5475448_0	314230.DSM3645_13885	1.338e-308	965.0	COG4946@1|root,COG4946@2|Bacteria,2IY4Z@203682|Planctomycetes	203682|Planctomycetes	M	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5475448_7	234267.Acid_1652	5.574e-11	72.0	COG0457@1|root,COG4995@1|root,COG5293@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,COG5293@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
HFD1_k127_5475448_8	1123368.AUIS01000011_gene1139	6.681e-08	64.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD1_k127_5475448_2	234267.Acid_5980	2.365e-126	408.0	COG0488@1|root,COG0488@2|Bacteria,3Y2H0@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD1_k127_5532119_7	234267.Acid_5357	4.661e-38	146.0	COG0129@1|root,COG0129@2|Bacteria,3Y3B1@57723|Acidobacteria	57723|Acidobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
HFD1_k127_5532119_8	316067.Geob_0974	9.731e-38	146.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6G@1224|Proteobacteria,42V7W@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	PFAM helix-turn-helix HxlR type	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD1_k127_5532119_9	1380346.JNIH01000009_gene1658	8.599e-10	68.0	COG0702@1|root,COG0702@2|Bacteria,2GKXI@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NmrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HFD1_k127_5532119_4	234267.Acid_2228	1.15e-53	204.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HFD1_k127_5532119_1	234267.Acid_2227	4.134e-117	392.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD1_k127_5532119_0	234267.Acid_2226	0.0	1311.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD1_k127_5532119_3	234267.Acid_2225	3.289e-85	283.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	coxS	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_5532119_2	497964.CfE428DRAFT_3504	7.76e-106	357.0	2DBKQ@1|root,2Z9U7@2|Bacteria,46U54@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5532119_6	1267535.KB906767_gene2266	4.055e-44	171.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD1_k127_5532119_5	234267.Acid_0380	1.276e-49	186.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD1_k127_5545310_0	234267.Acid_6986	1.422e-262	818.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
HFD1_k127_5545310_2	397948.Cmaq_1662	1.082e-23	113.0	COG1082@1|root,arCOG01900@2157|Archaea,2XRV4@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_5545310_1	1121028.ARQE01000019_gene2634	5.283e-75	266.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,2PKTM@255475|Aurantimonadaceae	28211|Alphaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_5576731_7	521674.Plim_2859	2.293e-60	230.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	ABC-SBP	-	-	ko:K01989,ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD1_k127_5576731_2	234267.Acid_2302	1.282e-93	317.0	COG2423@1|root,COG2423@2|Bacteria,3Y7M6@57723|Acidobacteria	57723|Acidobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD1_k127_5576731_6	234267.Acid_2372	9.847e-63	220.0	COG1225@1|root,COG1225@2|Bacteria,3Y8EY@57723|Acidobacteria	57723|Acidobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_5576731_4	234267.Acid_2539	6.905e-80	274.0	2DJMQ@1|root,32UDD@2|Bacteria,3Y57W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5576731_3	234267.Acid_2537	6.951e-88	294.0	COG1595@1|root,COG1595@2|Bacteria,3Y5RY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_5576731_1	234267.Acid_2536	2.098e-99	330.0	COG2197@1|root,COG2202@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_16,GGDEF,GerE,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_5576731_5	234267.Acid_2535	3.808e-64	227.0	COG0590@1|root,COG0590@2|Bacteria,3Y4ZN@57723|Acidobacteria	57723|Acidobacteria	FJ	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD1_k127_5576731_8	234267.Acid_5054	1.348e-52	190.0	COG2318@1|root,COG2318@2|Bacteria,3Y579@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD1_k127_55800_0	234267.Acid_2974	9.291e-172	568.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_55800_3	344747.PM8797T_19754	3.764e-47	183.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	AP_endonuc_2
HFD1_k127_55800_1	1267533.KB906733_gene3362	1.538e-128	433.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_55800_2	234267.Acid_7608	4.698e-110	359.0	COG3316@1|root,COG3316@2|Bacteria,3Y888@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HFD1_k127_558566_1	1340493.JNIF01000003_gene1539	6.298e-36	140.0	COG0597@1|root,COG0597@2|Bacteria,3Y55H@57723|Acidobacteria	57723|Acidobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD1_k127_558566_0	234267.Acid_5353	0.0	1177.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria	57723|Acidobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD1_k127_5607942_0	1267535.KB906767_gene4252	3.722e-189	599.0	COG3119@1|root,COG3119@2|Bacteria,3Y7FV@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF229)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD1_k127_5607942_1	234267.Acid_4607	5.601e-169	539.0	COG3250@1|root,COG3250@2|Bacteria,3Y47P@57723|Acidobacteria	57723|Acidobacteria	G	Beta galactosidase small chain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_5613046_8	234267.Acid_6712	2.958e-49	194.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria	57723|Acidobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD1_k127_5613046_5	234267.Acid_6713	6.268e-70	238.0	COG0864@1|root,COG0864@2|Bacteria,3Y83A@57723|Acidobacteria	57723|Acidobacteria	K	NikR C terminal nickel binding domain	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HFD1_k127_5613046_2	234267.Acid_6714	9.103e-97	325.0	COG0310@1|root,COG0310@2|Bacteria,3Y8I6@57723|Acidobacteria	57723|Acidobacteria	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
HFD1_k127_5613046_6	234267.Acid_6715	2.125e-64	241.0	COG0619@1|root,COG0619@2|Bacteria,3Y92N@57723|Acidobacteria	57723|Acidobacteria	P	Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HFD1_k127_5613046_3	234267.Acid_6716	5.996e-94	321.0	COG1122@1|root,COG1122@2|Bacteria,3Y84B@57723|Acidobacteria	57723|Acidobacteria	P	ABC transporter	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HFD1_k127_5613046_7	234267.Acid_6717	1.672e-58	206.0	COG1490@1|root,COG1490@2|Bacteria,3Y552@57723|Acidobacteria	57723|Acidobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HFD1_k127_5613046_1	234267.Acid_6718	5.252e-168	533.0	COG1577@1|root,COG1577@2|Bacteria	2|Bacteria	I	mevalonate kinase activity	mvaK2	-	2.7.1.36,2.7.1.43,2.7.4.2	ko:K00869,ko:K00938,ko:K16190	ko00040,ko00053,ko00520,ko00900,ko01100,ko01110,ko01130,ko04146,map00040,map00053,map00520,map00900,map01100,map01110,map01130,map04146	M00014,M00095	R01476,R02245,R03245	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD1_k127_5613046_0	234267.Acid_6722	2.453e-185	583.0	COG0150@1|root,COG0150@2|Bacteria,3Y2GN@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_5613046_4	234267.Acid_6723	4.101e-90	310.0	COG0299@1|root,COG0299@2|Bacteria,3Y49G@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HFD1_k127_5628205_2	234267.Acid_4120	2.686e-63	230.0	28VY7@1|root,3470P@2|Bacteria,3Y8J4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_4	234267.Acid_4119	5.097e-40	151.0	28VY7@1|root,2ZHZF@2|Bacteria,3Y97D@57723|Acidobacteria	57723|Acidobacteria	S	Conserved hypothetical protein 2217 (DUF2460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
HFD1_k127_5628205_6	234267.Acid_4118	1.399e-35	143.0	297ZP@1|root,2ZV5T@2|Bacteria,3Y972@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_5	234267.Acid_4116	1.025e-36	144.0	299A7@1|root,2ZWDD@2|Bacteria,3Y8TK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_0	234267.Acid_4115	3.503e-164	527.0	2EVZF@1|root,33PCY@2|Bacteria,3Y6QQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_3	234267.Acid_4114	4.826e-53	192.0	2CDPF@1|root,349CP@2|Bacteria,3Y8RA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_1	234267.Acid_4113	1.776e-66	234.0	2CB8V@1|root,342T5@2|Bacteria,3Y892@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5628205_8	234267.Acid_4112	6.834e-19	89.0	2CB8U@1|root,2ZFXN@2|Bacteria,3Y96M@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5632191_4	234267.Acid_1412	3.013e-190	596.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD1_k127_5632191_2	234267.Acid_1411	1.051e-201	636.0	COG4963@1|root,COG4963@2|Bacteria,3Y44H@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD1_k127_5632191_5	234267.Acid_1410	1.023e-171	553.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD1_k127_5632191_7	234267.Acid_1409	4.327e-119	389.0	COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria	57723|Acidobacteria	U	PFAM SAF domain	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD1_k127_5632191_9	240015.ACP_1103	0.0005006	48.0	COG3847@1|root,COG3847@2|Bacteria,3Y5Y3@57723|Acidobacteria,2JNT7@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	-
HFD1_k127_5632191_1	234267.Acid_1408	3.3e-220	695.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
HFD1_k127_5632191_6	234267.Acid_1406	5.994e-131	421.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_5632191_3	234267.Acid_2269	2.169e-200	683.0	COG3391@1|root,COG5555@1|root,COG3391@2|Bacteria,COG5555@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Metallophos
HFD1_k127_5632191_0	234267.Acid_2270	8.608e-258	825.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5637672_4	234267.Acid_0911	8.747e-44	166.0	COG4775@1|root,COG4775@2|Bacteria,3Y7I1@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	POTRA
HFD1_k127_5637672_1	234267.Acid_0912	2.771e-256	798.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria	57723|Acidobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD1_k127_5637672_3	1340493.JNIF01000004_gene488	1.72e-69	243.0	COG0321@1|root,COG0321@2|Bacteria,3Y448@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
HFD1_k127_5637672_2	1121920.AUAU01000004_gene789	3.167e-112	378.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria	57723|Acidobacteria	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_5637672_0	234267.Acid_0916	9.782e-260	814.0	COG3733@1|root,COG3733@2|Bacteria,3Y3S1@57723|Acidobacteria	57723|Acidobacteria	Q	Copper amine oxidase, N2 domain	-	-	1.4.3.21	ko:K00276	ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110	-	R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740	RC00062,RC00189,RC00676,RC01052	ko00000,ko00001,ko01000	-	-	-	Cu_amine_oxid,Cu_amine_oxidN2,Cu_amine_oxidN3
HFD1_k127_5640648_9	234267.Acid_0169	7.749e-73	246.0	COG0229@1|root,COG0229@2|Bacteria,3Y4XW@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD1_k127_5640648_15	234267.Acid_2192	1.715e-39	162.0	COG4944@1|root,COG4944@2|Bacteria	2|Bacteria	K	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HFD1_k127_5640648_11	234267.Acid_2193	2.058e-59	217.0	COG1595@1|root,COG1595@2|Bacteria,3Y863@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_5640648_13	234267.Acid_0317	3.602e-44	169.0	COG5429@1|root,COG5429@2|Bacteria,3Y4TV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HFD1_k127_5640648_4	234267.Acid_0171	7.991e-162	540.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD1_k127_5640648_12	861299.J421_1636	7.582e-48	179.0	2B1QU@1|root,31U6H@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3224)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3224
HFD1_k127_5640648_5	1267533.KB906736_gene1321	2.782e-118	391.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD1_k127_5640648_16	1123269.NX02_12580	5.092e-28	133.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria,2K2JD@204457|Sphingomonadales	204457|Sphingomonadales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_5640648_0	234267.Acid_7849	7.615e-289	918.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5640648_18	1121920.AUAU01000021_gene2512	1.128e-21	101.0	290IA@1|root,2ZN74@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5640648_8	234267.Acid_0501	1.158e-78	278.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_5640648_7	234267.Acid_0502	4.348e-85	286.0	28ZWN@1|root,2ZMM4@2|Bacteria,3Y8RZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5640648_2	234267.Acid_0802	5.397e-198	628.0	COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_5640648_6	234267.Acid_7907	5.685e-111	373.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7907|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5640648_1	316056.RPC_1039	1.089e-235	738.0	COG3177@1|root,COG3177@2|Bacteria,1MVW0@1224|Proteobacteria,2TU9A@28211|Alphaproteobacteria,3JV8G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HFD1_k127_5640648_10	234267.Acid_7906	2.756e-70	241.0	COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria	57723|Acidobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD1_k127_5640648_17	443598.AUFA01000100_gene7191	5.098e-22	102.0	COG1321@1|root,COG1321@2|Bacteria,1N90S@1224|Proteobacteria,2UES8@28211|Alphaproteobacteria,3K13J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LexA DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repress,LexA_DNA_bind
HFD1_k127_5640648_14	1340493.JNIF01000004_gene616	2.084e-41	161.0	COG4219@1|root,COG4219@2|Bacteria,3Y63E@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD1_k127_5640648_19	66875.JODY01000030_gene3982	1.505e-11	67.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_5650118_1	161156.JQKW01000008_gene544	8.946e-17	92.0	COG3203@1|root,COG3203@2|Bacteria,2GI8G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5650118_0	1379270.AUXF01000003_gene3567	8.381e-28	113.0	COG5002@1|root,COG5002@2|Bacteria,1ZT2H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HAMP domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HFD1_k127_5652322_11	483219.LILAB_05305	1.018e-36	150.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5652322_13	401053.AciPR4_2187	3.551e-21	108.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DY@57723|Acidobacteria,2JKJB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5652322_10	234267.Acid_5730	1.955e-38	146.0	COG1695@1|root,COG1695@2|Bacteria,3Y5BK@57723|Acidobacteria	57723|Acidobacteria	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5652322_1	234267.Acid_1988	1.304e-317	977.0	COG0673@1|root,COG0673@2|Bacteria,3Y6C9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_5652322_6	234267.Acid_3930	7.937e-132	436.0	COG3828@1|root,COG3828@2|Bacteria,3Y470@57723|Acidobacteria	57723|Acidobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
HFD1_k127_5652322_15	234267.Acid_2990	8.651e-09	66.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5652322_14	234267.Acid_2990	9.649e-16	81.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5652322_4	1382359.JIAL01000001_gene2498	1.146e-175	557.0	COG0627@1|root,COG0627@2|Bacteria,3Y63W@57723|Acidobacteria,2JMD1@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD1_k127_5652322_12	234267.Acid_2990	3.666e-27	114.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5652322_2	234267.Acid_5647	7.733e-306	957.0	COG3507@1|root,COG3507@2|Bacteria,3Y89B@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
HFD1_k127_5652322_3	234267.Acid_5646	2.045e-222	704.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_5652322_5	935567.JAES01000027_gene1296	1.529e-164	527.0	COG3405@1|root,COG3405@2|Bacteria,1R633@1224|Proteobacteria,1S1FG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	glycoside hydrolase, family 8	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	CBM_2,Glyco_hydro_8
HFD1_k127_5652322_0	234267.Acid_2992	0.0	1056.0	COG3534@1|root,COG3534@2|Bacteria,3Y35F@57723|Acidobacteria	57723|Acidobacteria	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HFD1_k127_5652322_7	234267.Acid_2130	6.294e-121	394.0	COG0657@1|root,COG0657@2|Bacteria,3Y4WR@57723|Acidobacteria	57723|Acidobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD1_k127_5652322_8	1123277.KB893184_gene4089	2.089e-83	280.0	COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,47NR0@768503|Cytophagia	976|Bacteroidetes	S	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD1_k127_5652322_17	246200.SPO3286	0.0004016	49.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4NBYM@97050|Ruegeria	28211|Alphaproteobacteria	P	Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_5652322_16	234267.Acid_6137	2.029e-07	61.0	COG4932@1|root,COG4932@2|Bacteria,3Y6F1@57723|Acidobacteria	57723|Acidobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5652322_9	234267.Acid_6875	1.507e-82	277.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_5657524_6	234267.Acid_4092	5.399e-76	259.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_5657524_5	234267.Acid_4093	3.804e-77	273.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_5657524_4	234267.Acid_4094	2.785e-90	317.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
HFD1_k127_5657524_7	234267.Acid_4095	7.94e-68	243.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD1_k127_5657524_9	1122604.JONR01000025_gene4602	1.84e-19	100.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_5657524_3	1340493.JNIF01000003_gene4381	1.522e-104	351.0	COG0546@1|root,COG0546@2|Bacteria,3Y621@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase
HFD1_k127_5657524_0	234267.Acid_3555	2.71e-178	561.0	COG1915@1|root,COG1915@2|Bacteria,3Y7FB@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5657524_2	234267.Acid_3554	2.881e-127	428.0	COG2870@1|root,COG2870@2|Bacteria,3Y680@57723|Acidobacteria	57723|Acidobacteria	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD1_k127_5657524_1	234267.Acid_3544	1.127e-151	500.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria	57723|Acidobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5657524_8	234267.Acid_1577	4.39e-22	97.0	COG1082@1|root,COG1082@2|Bacteria,3Y8GU@57723|Acidobacteria	2|Bacteria	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_5658111_0	234267.Acid_3856	2.239e-163	519.0	COG0040@1|root,COG0040@2|Bacteria,3Y31Q@57723|Acidobacteria	57723|Acidobacteria	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HFD1_k127_5658111_2	234267.Acid_3857	2.953e-66	231.0	COG0139@1|root,COG0139@2|Bacteria,3Y4SN@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	-	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
HFD1_k127_5658111_1	234267.Acid_4244	1.412e-153	492.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_5658111_3	234267.Acid_4243	3.73e-44	175.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4243|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5672009_3	234267.Acid_0463	2.95e-20	90.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD1_k127_5672009_0	234267.Acid_0462	8.528e-69	237.0	COG0712@1|root,COG0712@2|Bacteria,3Y4Z4@57723|Acidobacteria	57723|Acidobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD1_k127_5672009_1	234267.Acid_0461	7.05e-48	183.0	COG0711@1|root,COG0711@2|Bacteria,3Y4UJ@57723|Acidobacteria	57723|Acidobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD1_k127_5672009_2	234267.Acid_0460	4.047e-41	156.0	COG0711@1|root,COG0711@2|Bacteria,3Y4WK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the ATPase B chain family	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD1_k127_5672009_6	1288826.MSNKSG1_15422	3.798e-05	54.0	COG0666@1|root,COG0666@2|Bacteria,1RE5N@1224|Proteobacteria,1SYU7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AnkB protein involved in protection against oxygen	ankB	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2
HFD1_k127_5673635_0	880073.Calab_3359	2.586e-13	84.0	COG4632@1|root,COG4632@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Metallophos,NAGPA,Polysacc_deac_1,SLH
HFD1_k127_568266_9	234267.Acid_3677	4.306e-35	143.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_568266_0	234267.Acid_6531	1.129e-249	780.0	COG2272@1|root,COG2272@2|Bacteria,3Y6S1@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_568266_8	1340493.JNIF01000003_gene1556	1.555e-45	175.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT,HEAT_2
HFD1_k127_568266_4	234267.Acid_0844	4.358e-109	383.0	COG0673@1|root,COG0673@2|Bacteria,3Y6RA@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,TAT_signal
HFD1_k127_568266_3	234267.Acid_2876	2.28e-139	461.0	COG3509@1|root,COG3509@2|Bacteria,3Y3SY@57723|Acidobacteria	2|Bacteria	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HFD1_k127_568266_7	234267.Acid_4277	3.084e-62	222.0	2AU2S@1|root,31JP5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_568266_10	1121904.ARBP01000033_gene3213	1.089e-23	118.0	28K60@1|root,2Z9UH@2|Bacteria,4NHE6@976|Bacteroidetes,47UNS@768503|Cytophagia	976|Bacteroidetes	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
HFD1_k127_568266_1	761193.Runsl_2557	4.856e-162	523.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47NH0@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_568266_5	639030.JHVA01000001_gene258	8.501e-90	302.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	PmoA,ThuA
HFD1_k127_568266_2	1340493.JNIF01000003_gene3009	2.439e-160	516.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Oxidoreduct_C,PmoA
HFD1_k127_568266_6	452637.Oter_3714	3.006e-67	243.0	COG4124@1|root,COG4124@2|Bacteria,46TGN@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HFD1_k127_5682685_2	234267.Acid_4012	1.796e-110	363.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5682685_0	234267.Acid_3092	4.713e-130	422.0	COG0169@1|root,COG0169@2|Bacteria	2|Bacteria	E	shikimate 3-dehydrogenase (NADP+) activity	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N,ThiF
HFD1_k127_5682685_1	69395.JQLZ01000001_gene3018	8.871e-126	416.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_568739_4	251229.Chro_1869	6.007e-17	81.0	2DNS7@1|root,32YWC@2|Bacteria,1G8QD@1117|Cyanobacteria,3VKK4@52604|Pleurocapsales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD1_k127_568739_3	1170562.Cal6303_2768	2.585e-24	104.0	COG0399@1|root,COG0399@2|Bacteria,1GDTU@1117|Cyanobacteria,1HSKF@1161|Nostocales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD1_k127_568739_1	234267.Acid_7567	2.853e-190	604.0	COG1538@1|root,COG1538@2|Bacteria,3Y3JU@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HFD1_k127_568739_0	234267.Acid_7568	0.0	1672.0	COG0841@1|root,COG0841@2|Bacteria,3Y2RX@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_568739_2	234267.Acid_7569	4.786e-163	523.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_5701541_6	234267.Acid_4910	5.596e-39	153.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_5701541_4	234267.Acid_6363	1.484e-82	289.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_5701541_2	234267.Acid_6362	3.379e-108	364.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,SH3_3
HFD1_k127_5701541_5	234267.Acid_6359	6.15e-42	157.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD1_k127_5701541_3	234267.Acid_6358	5.196e-83	287.0	COG0637@1|root,COG0637@2|Bacteria,3Y7V3@57723|Acidobacteria	57723|Acidobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD1_k127_5701541_0	234267.Acid_6357	1.865e-254	806.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GAF_2,GGDEF,HATPase_c,HTH_17,HTH_18,HisKA,PAS,PAS_4,PAS_8,PAS_9,Reg_prop,Response_reg,Y_Y_Y
HFD1_k127_5701541_1	234267.Acid_0601	1.958e-119	388.0	COG1912@1|root,COG1912@2|Bacteria,3Y50E@57723|Acidobacteria	57723|Acidobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HFD1_k127_5701541_7	234267.Acid_0600	1.057e-26	110.0	COG1104@1|root,COG1104@2|Bacteria,3Y389@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_5710770_10	234267.Acid_7924	1.906e-24	105.0	2BMF1@1|root,32FZM@2|Bacteria,3Y8ZK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5710770_7	234267.Acid_7925	7.141e-60	217.0	COG3832@1|root,COG3832@2|Bacteria,3Y94H@57723|Acidobacteria	57723|Acidobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5710770_6	234267.Acid_7926	9.227e-67	231.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD1_k127_5710770_0	234267.Acid_7927	0.0	1240.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD1_k127_5710770_11	1123073.KB899242_gene1159	1.05e-14	82.0	COG3209@1|root,COG3386@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,1SZ73@1236|Gammaproteobacteria	1224|Proteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_5710770_5	1123278.KB893615_gene5179	1.112e-80	299.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,47PBP@768503|Cytophagia	976|Bacteroidetes	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_5710770_8	1340493.JNIF01000003_gene1448	9.182e-46	190.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	CP_1076	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Autotransporter,DUF1929,Glyoxal_oxid_N,PA14
HFD1_k127_5710770_1	234267.Acid_7928	3.124e-123	413.0	COG1064@1|root,COG1064@2|Bacteria,3Y3X1@57723|Acidobacteria	57723|Acidobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_5710770_2	234267.Acid_7929	1.898e-104	342.0	COG0491@1|root,COG0491@2|Bacteria,3Y4DN@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_5710770_9	234267.Acid_7930	3.712e-40	153.0	2DYZH@1|root,34BW9@2|Bacteria,3Y8R9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5710770_3	234267.Acid_7931	3.263e-100	333.0	COG0354@1|root,COG0354@2|Bacteria,3Y2PI@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HFD1_k127_5710770_4	234267.Acid_7932	8.191e-94	310.0	COG0613@1|root,COG0613@2|Bacteria,3Y5C1@57723|Acidobacteria	57723|Acidobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HFD1_k127_5717519_1	234267.Acid_6648	1.646e-271	842.0	COG1629@1|root,COG4771@2|Bacteria,3Y6QJ@57723|Acidobacteria	234267.Acid_6648|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5717519_2	234267.Acid_0395	4.651e-70	245.0	COG2207@1|root,COG2207@2|Bacteria,3Y7NC@57723|Acidobacteria	57723|Acidobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HFD1_k127_5717519_3	234267.Acid_0396	2.794e-38	147.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,Cupin_7,DUF4437
HFD1_k127_5717519_0	234267.Acid_1639	0.0	1060.0	COG4993@1|root,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_5717648_1	1121920.AUAU01000009_gene1860	3.106e-67	231.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD1_k127_5717648_0	1121920.AUAU01000009_gene1859	1.596e-136	447.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
HFD1_k127_5717648_2	1121920.AUAU01000009_gene1858	4.883e-59	209.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HFD1_k127_5717648_4	1158292.JPOE01000002_gene2299	1.822e-11	70.0	COG0664@1|root,COG0664@2|Bacteria,1N3F0@1224|Proteobacteria,2VVAQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD1_k127_5717648_3	870187.Thini_4231	5.832e-24	113.0	COG4191@1|root,COG4191@2|Bacteria,1QXD8@1224|Proteobacteria,1T4M2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8
HFD1_k127_5719638_0	1340493.JNIF01000003_gene3962	4.487e-137	443.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,ThuA
HFD1_k127_5719638_1	1210884.HG799463_gene9623	1.63e-52	191.0	COG1225@1|root,COG1225@2|Bacteria,2IZYV@203682|Planctomycetes	203682|Planctomycetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_5723946_0	234267.Acid_6670	7.532e-180	566.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD1_k127_5723946_3	234267.Acid_6671	2.155e-135	438.0	COG3872@1|root,COG3872@2|Bacteria,3Y66K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
HFD1_k127_5723946_4	234267.Acid_6672	2.37e-122	398.0	COG1090@1|root,COG1090@2|Bacteria,3Y4IA@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HFD1_k127_5723946_2	234267.Acid_6673	1.134e-141	461.0	COG0415@1|root,COG0415@2|Bacteria,3Y31R@57723|Acidobacteria	57723|Acidobacteria	L	PFAM DNA photolyase, FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HFD1_k127_5723946_1	251221.35211765	5.337e-169	559.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_5723946_5	234267.Acid_6990	9.258e-89	299.0	COG1014@1|root,COG1014@2|Bacteria,3Y6SM@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HFD1_k127_5723946_6	234267.Acid_6989	2e-58	203.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD1_k127_5724245_2	1340493.JNIF01000003_gene3494	1.779e-55	209.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.1.1.102	ko:K06978,ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	AXE1,Big_5,LTD,Peptidase_S9,Tannase
HFD1_k127_5724245_0	1267535.KB906767_gene3454	5.561e-155	498.0	COG4299@1|root,COG4299@2|Bacteria,3Y3Q4@57723|Acidobacteria	2|Bacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
HFD1_k127_5724245_1	1267535.KB906767_gene1540	8.452e-95	322.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_572726_0	1267533.KB906736_gene1177	3.729e-295	927.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_572726_2	234267.Acid_1452	5.839e-57	204.0	COG2134@1|root,COG2134@2|Bacteria,3Y7SW@57723|Acidobacteria	57723|Acidobacteria	I	cdp-diacylglycerol pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_572726_1	1267535.KB906767_gene186	2.537e-190	604.0	COG2721@1|root,COG2721@2|Bacteria,3Y6SX@57723|Acidobacteria	57723|Acidobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
HFD1_k127_5730891_1	1121104.AQXH01000002_gene710	6.415e-16	79.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NH06@976|Bacteroidetes,1J105@117747|Sphingobacteriia	976|Bacteroidetes	HP	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
HFD1_k127_5730891_0	1379270.AUXF01000005_gene336	2.504e-98	341.0	28PJE@1|root,2ZC90@2|Bacteria,1ZTV5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SusD_RagB
HFD1_k127_5758984_1	1121104.AQXH01000002_gene710	6.415e-16	79.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NH06@976|Bacteroidetes,1J105@117747|Sphingobacteriia	976|Bacteroidetes	HP	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
HFD1_k127_5758984_0	1379270.AUXF01000005_gene336	3.049e-99	344.0	28PJE@1|root,2ZC90@2|Bacteria,1ZTV5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SusD_RagB
HFD1_k127_5761227_0	1340493.JNIF01000004_gene1048	1.563e-189	598.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_5761227_1	1340493.JNIF01000004_gene1047	1.248e-38	148.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PSCyt1,PSCyt2,PSD1
HFD1_k127_5775845_4	243231.GSU0537	3.275e-13	76.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WTPC@28221|Deltaproteobacteria,43TG7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
HFD1_k127_5775845_2	1267535.KB906767_gene3216	5.813e-34	141.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD1_k127_5775845_0	1396141.BATP01000007_gene5761	8.337e-153	511.0	COG5164@1|root,COG5164@2|Bacteria,46XD1@74201|Verrucomicrobia,2IVH5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5775845_1	1267535.KB906767_gene3728	1.25e-103	359.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_5775845_3	1340493.JNIF01000004_gene736	3.246e-17	85.0	COG1680@1|root,COG1680@2|Bacteria,3Y6TE@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_5788663_6	1210884.HG799465_gene11871	1.348e-19	98.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,HHH_8,PHP
HFD1_k127_5788663_1	1267534.KB906754_gene3511	1.916e-130	423.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria	57723|Acidobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HFD1_k127_5788663_5	32057.KB217478_gene5036	1.388e-63	232.0	COG0753@1|root,COG2373@1|root,COG0753@2|Bacteria,COG2373@2|Bacteria,1GQ3G@1117|Cyanobacteria,1HUC4@1161|Nostocales	1117|Cyanobacteria	P	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HFD1_k127_5788663_2	404589.Anae109_3248	3.169e-112	381.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria	1224|Proteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HFD1_k127_5788663_4	67373.JOBF01000002_gene1143	6.868e-77	267.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD1_k127_5788663_3	234267.Acid_0995	6.836e-100	331.0	COG3391@1|root,COG3391@2|Bacteria,3Y7I2@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5788663_0	234267.Acid_1929	0.0	1028.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,PIG-L
HFD1_k127_5795653_2	1340493.JNIF01000003_gene3565	1.395e-20	95.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_5795653_3	1089547.KB913013_gene761	1.693e-12	72.0	COG4319@1|root,COG4319@2|Bacteria,4NSA0@976|Bacteroidetes,47RMW@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_5795653_0	1123508.JH636442_gene4053	6.104e-154	500.0	COG4102@1|root,COG4102@2|Bacteria,2IYDS@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_5795653_1	1123508.JH636442_gene4052	1.439e-79	273.0	COG2010@1|root,COG2010@2|Bacteria,2IXUQ@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1553)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt2,PSD1
HFD1_k127_5798543_25	234267.Acid_5926	4.821e-14	72.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD1_k127_5798543_12	234267.Acid_5926	3.172e-92	313.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD1_k127_5798543_10	234267.Acid_6464	4.868e-125	411.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_6464|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5798543_3	234267.Acid_4435	8.683e-294	915.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5798543_11	278963.ATWD01000001_gene3850	4.675e-106	356.0	COG0501@1|root,COG0501@2|Bacteria,3Y2PP@57723|Acidobacteria,2JI24@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M48_N
HFD1_k127_5798543_7	1242864.D187_004781	1.978e-169	545.0	COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria	1224|Proteobacteria	G	Protein of unknown function (DUF4038)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
HFD1_k127_5798543_2	234267.Acid_0605	8.715e-312	968.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria	57723|Acidobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD1_k127_5798543_19	1340493.JNIF01000003_gene2223	8.151e-47	171.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5798543_5	234267.Acid_5487	1.668e-249	776.0	COG2873@1|root,COG2873@2|Bacteria,3Y2JU@57723|Acidobacteria	57723|Acidobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD1_k127_5798543_0	234267.Acid_4430	0.0	1133.0	COG0457@1|root,COG0726@1|root,COG4249@1|root,COG0457@2|Bacteria,COG0726@2|Bacteria,COG4249@2|Bacteria,3Y77C@57723|Acidobacteria	57723|Acidobacteria	G	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,Polysacc_deac_1,TPR_2,WD40
HFD1_k127_5798543_17	438753.AZC_3166	5.249e-54	199.0	COG3258@1|root,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,2TWPT@28211|Alphaproteobacteria,3F2DW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrome_CBB3
HFD1_k127_5798543_8	760117.JN27_17825	1.55e-151	488.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria,47403@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD1_k127_5798543_9	234267.Acid_6893	3.468e-129	418.0	COG1388@1|root,COG1388@2|Bacteria,3Y4VG@57723|Acidobacteria	57723|Acidobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD1_k127_5798543_26	1125863.JAFN01000001_gene2333	7.651e-12	68.0	COG2161@1|root,COG2161@2|Bacteria,1R2Q0@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD1_k127_5798543_23	103690.17131778	1.668e-24	108.0	COG3744@1|root,COG3744@2|Bacteria,1G5PR@1117|Cyanobacteria,1HSI7@1161|Nostocales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_5798543_4	1267535.KB906767_gene39	1.353e-284	896.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5798543_15	234267.Acid_1212	1.427e-66	238.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03770,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD1_k127_5798543_22	1267535.KB906767_gene343	1.885e-29	120.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_5798543_24	1340493.JNIF01000003_gene4158	6.694e-16	80.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_5798543_6	234267.Acid_1521	4.618e-180	573.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5798543_14	234267.Acid_1520	4.798e-67	243.0	COG2242@1|root,COG2242@2|Bacteria,3Y88R@57723|Acidobacteria	57723|Acidobacteria	H	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5798543_13	234267.Acid_4300	4.965e-68	239.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HFD1_k127_5798543_16	234267.Acid_4299	9.896e-55	193.0	COG0776@1|root,COG0776@2|Bacteria,3Y56V@57723|Acidobacteria	57723|Acidobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_5798543_1	234267.Acid_4298	0.0	1011.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3Y3DA@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD1_k127_5798543_18	234267.Acid_3321	2.153e-50	181.0	2CB8T@1|root,349A2@2|Bacteria,3Y8JH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
HFD1_k127_5807602_1	234267.Acid_4773	4.33e-250	782.0	COG0577@1|root,COG0577@2|Bacteria,3Y67P@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_5807602_16	234267.Acid_4772	1.08e-57	206.0	COG1695@1|root,COG1695@2|Bacteria,3Y7WH@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_5807602_19	671143.DAMO_1089	4.843e-27	115.0	2C5EY@1|root,32YQJ@2|Bacteria,2NREI@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HFD1_k127_5807602_18	179408.Osc7112_1843	1.635e-30	123.0	2DNRM@1|root,32YT2@2|Bacteria,1G8FD@1117|Cyanobacteria,1HD5I@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HFD1_k127_5807602_9	1340493.JNIF01000003_gene3901	1.392e-116	384.0	COG0111@1|root,COG0111@2|Bacteria,3Y3VD@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD1_k127_5807602_8	864051.BurJ1DRAFT_2776	7.474e-130	427.0	COG2010@1|root,COG2010@2|Bacteria,1R1VN@1224|Proteobacteria,2WI66@28216|Betaproteobacteria,1KN79@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HFD1_k127_5807602_6	864051.BurJ1DRAFT_2775	2.666e-145	472.0	COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2WEME@28216|Betaproteobacteria,1KN2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_5807602_11	204669.Acid345_0126	4.297e-110	361.0	COG0580@1|root,COG0580@2|Bacteria,3Y3SK@57723|Acidobacteria,2JHX3@204432|Acidobacteriia	204432|Acidobacteriia	G	Major intrinsic protein	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD1_k127_5807602_10	378806.STAUR_7640	6.491e-111	375.0	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,4396X@68525|delta/epsilon subdivisions,2X4DR@28221|Deltaproteobacteria,2YYTQ@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,TPR_2
HFD1_k127_5807602_15	234267.Acid_0517	2e-66	228.0	COG4101@1|root,COG4101@2|Bacteria,3Y832@57723|Acidobacteria	57723|Acidobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_5807602_7	234267.Acid_3896	7.276e-139	450.0	COG1454@1|root,COG1454@2|Bacteria,3Y575@57723|Acidobacteria	57723|Acidobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HFD1_k127_5807602_20	379066.GAU_0054	1.355e-26	117.0	COG1359@1|root,COG1359@2|Bacteria,1ZU18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD1_k127_5807602_14	1340493.JNIF01000003_gene2645	2.135e-88	329.0	COG2312@1|root,COG2312@2|Bacteria,3Y8PV@57723|Acidobacteria	57723|Acidobacteria	S	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Erythro_esteras
HFD1_k127_5807602_13	234267.Acid_5578	9.017e-90	325.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_5578|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5807602_12	234267.Acid_3692	7.354e-110	365.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD1_k127_5807602_0	234267.Acid_4487	4.849e-283	880.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_5807602_3	234267.Acid_4281	3.594e-196	622.0	COG1804@1|root,COG1804@2|Bacteria,3Y4ZM@57723|Acidobacteria	57723|Acidobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD1_k127_5807602_5	999541.bgla_1g19760	1.011e-169	545.0	COG2851@1|root,COG2851@2|Bacteria,1N25B@1224|Proteobacteria,2VHYJ@28216|Betaproteobacteria,1K23W@119060|Burkholderiaceae	28216|Betaproteobacteria	C	TIGRFAM citrate H symporter, CitMHS family	-	-	-	ko:K03300	-	-	-	-	ko00000	2.A.11	-	-	CitMHS
HFD1_k127_5807602_2	234267.Acid_7852	1.231e-222	697.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_5807602_4	1340493.JNIF01000003_gene2866	2.425e-183	580.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_5807602_17	1123270.ATUR01000002_gene2330	3.3e-38	166.0	COG1649@1|root,COG1649@2|Bacteria,1NP4V@1224|Proteobacteria,2UDGK@28211|Alphaproteobacteria,2K1N8@204457|Sphingomonadales	204457|Sphingomonadales	S	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
HFD1_k127_5863702_1	234267.Acid_2993	9.619e-20	95.0	COG3507@1|root,COG3507@2|Bacteria,3Y6BR@57723|Acidobacteria	57723|Acidobacteria	G	family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_5863702_0	694427.Palpr_1656	1.537e-188	603.0	COG3507@1|root,COG3507@2|Bacteria,4NEMG@976|Bacteroidetes,2FPP1@200643|Bacteroidia,22WTR@171551|Porphyromonadaceae	2|Bacteria	G	F5 8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,F5_F8_type_C,Glyco_hydro_43
HFD1_k127_5863702_2	595460.RRSWK_01081	3.585e-08	59.0	COG3119@1|root,COG3119@2|Bacteria,2IWVY@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_5864382_0	1297742.A176_07244	2.833e-113	383.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1MVGV@1224|Proteobacteria,42WJ6@68525|delta/epsilon subdivisions,2WQ9K@28221|Deltaproteobacteria,2YXTM@29|Myxococcales	28221|Deltaproteobacteria	PT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
HFD1_k127_5864382_1	379066.GAU_1133	4.687e-16	80.0	2F044@1|root,316N5@2|Bacteria,1ZUB3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5875163_1	1267535.KB906767_gene1270	4.275e-56	199.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	intE	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_1,Phage_int_SAM_1,Phage_integrase
HFD1_k127_5875163_0	861299.J421_5698	2.161e-57	207.0	COG2197@1|root,COG2197@2|Bacteria,1ZUCS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_5875163_2	204669.Acid345_3749	1.603e-15	80.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2ZI@57723|Acidobacteria,2JI9X@204432|Acidobacteriia	204432|Acidobacteriia	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HFD1_k127_5877731_18	234267.Acid_2118	7.202e-76	274.0	COG0438@1|root,COG0438@2|Bacteria,3Y64B@57723|Acidobacteria	2|Bacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD1_k127_5877731_9	234267.Acid_2117	2.617e-126	421.0	COG2271@1|root,COG2271@2|Bacteria,3Y6CQ@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_5877731_4	234267.Acid_2116	1.345e-224	713.0	COG4783@1|root,COG4783@2|Bacteria,3Y7PN@57723|Acidobacteria	57723|Acidobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5877731_15	682795.AciX8_1609	1.083e-84	289.0	COG0584@1|root,COG0584@2|Bacteria,3Y41Q@57723|Acidobacteria,2JHJG@204432|Acidobacteriia	204432|Acidobacteriia	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD1_k127_5877731_30	1038862.KB893806_gene2931	2.064e-06	51.0	COG0582@1|root,COG0582@2|Bacteria,1RBMJ@1224|Proteobacteria,2U0ET@28211|Alphaproteobacteria,3JYWG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HFD1_k127_5877731_31	1385521.N803_03610	9.616e-06	55.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HFD1_k127_5877731_1	1267535.KB906767_gene4753	0.0	1305.0	COG0419@1|root,COG0515@1|root,COG0419@2|Bacteria,COG0515@2|Bacteria	2|Bacteria	KLT	protein kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13582,ko:K13924	ko02020,ko02030,ko04112,map02020,map02030,map04112	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_15,AAA_21,DUF4339,TMP_2,Tubulin_2
HFD1_k127_5877731_12	1267535.KB906767_gene921	6.193e-122	417.0	COG3522@1|root,COG3522@2|Bacteria,3Y3ZF@57723|Acidobacteria,2JKHI@204432|Acidobacteriia	204432|Acidobacteriia	S	type VI secretion protein, VC_A0114 family	-	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
HFD1_k127_5877731_23	330214.NIDE2023	6.257e-41	161.0	2C6PZ@1|root,32V0V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5877731_10	330214.NIDE2002	3.417e-123	409.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_5877731_19	399739.Pmen_2337	4.182e-61	221.0	COG4447@1|root,COG4447@2|Bacteria,1PK4D@1224|Proteobacteria,1TBR0@1236|Gammaproteobacteria,1YJXK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5877731_17	399739.Pmen_2336	1.233e-76	274.0	COG1475@1|root,COG1475@2|Bacteria,1QYN0@1224|Proteobacteria,1SZ8J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	GHH signature containing HNH/Endo VII superfamily nuclease toxin  2	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,Tox-GHH2
HFD1_k127_5877731_11	399739.Pmen_2335	1.291e-122	402.0	COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria,1YIZ4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	synthase	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
HFD1_k127_5877731_28	1396141.BATP01000024_gene835	9.332e-17	87.0	COG5351@1|root,COG5351@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2169)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169
HFD1_k127_5877731_14	314278.NB231_12129	9.149e-118	389.0	COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,1S0MS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169
HFD1_k127_5877731_26	1538295.JY96_10695	2.448e-34	137.0	2CMCS@1|root,32SEB@2|Bacteria,1N3SA@1224|Proteobacteria,2VTVV@28216|Betaproteobacteria,1KP7A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5877731_3	330214.NIDE1987	6.626e-247	782.0	COG3501@1|root,COG4253@1|root,COG3501@2|Bacteria,COG4253@2|Bacteria,3J13S@40117|Nitrospirae	40117|Nitrospirae	S	Phage late control gene D protein (GPD)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
HFD1_k127_5877731_16	1267535.KB906767_gene2498	4.677e-80	286.0	COG3520@1|root,COG3520@2|Bacteria,3Y49W@57723|Acidobacteria,2JMM9@204432|Acidobacteriia	204432|Acidobacteriia	S	type VI secretion protein, VC_A0111 family	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
HFD1_k127_5877731_7	234267.Acid_0237	8.905e-175	569.0	COG3519@1|root,COG3519@2|Bacteria,3Y34T@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion system, TssF	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
HFD1_k127_5877731_27	349163.Acry_3075	7.77e-26	112.0	COG3518@1|root,COG3518@2|Bacteria,1RG8W@1224|Proteobacteria,2UG2U@28211|Alphaproteobacteria,2JX48@204441|Rhodospirillales	204441|Rhodospirillales	S	Gene 25-like lysozyme	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
HFD1_k127_5877731_22	1340493.JNIF01000004_gene590	1.712e-44	178.0	COG3515@1|root,COG3515@2|Bacteria,3Y2NF@57723|Acidobacteria	57723|Acidobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N,T6SS_VasJ
HFD1_k127_5877731_21	1120999.JONM01000005_gene3770	2.94e-46	176.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2WEFR@28216|Betaproteobacteria,2KPCB@206351|Neisseriales	206351|Neisseriales	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD1_k127_5877731_6	886293.Sinac_2410	7.249e-211	667.0	COG3517@1|root,COG3517@2|Bacteria,2IXI1@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM type VI secretion protein, EvpB VC_A0108 family	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
HFD1_k127_5877731_20	1265505.ATUG01000001_gene4583	7.817e-55	197.0	COG3516@1|root,COG3516@2|Bacteria,1R9Y7@1224|Proteobacteria,42UQR@68525|delta/epsilon subdivisions,2WQYW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
HFD1_k127_5877731_13	234267.Acid_0223	1.856e-118	423.0	COG3523@1|root,COG3523@2|Bacteria,3Y3IQ@57723|Acidobacteria	57723|Acidobacteria	S	ImcF-related N-terminal domain	-	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
HFD1_k127_5877731_25	234267.Acid_0224	3.478e-37	150.0	COG3455@1|root,COG3455@2|Bacteria,3Y4ZZ@57723|Acidobacteria	57723|Acidobacteria	S	Type VI secretion system protein DotU	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU
HFD1_k127_5877731_32	579138.Zymop_1178	8.467e-05	53.0	2BX7C@1|root,2ZB4P@2|Bacteria,1NSDF@1224|Proteobacteria,2U03Z@28211|Alphaproteobacteria,2KEX4@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5877731_5	1267535.KB906767_gene4753	7.996e-222	742.0	COG0419@1|root,COG0515@1|root,COG0419@2|Bacteria,COG0515@2|Bacteria	2|Bacteria	KLT	protein kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13582,ko:K13924	ko02020,ko02030,ko04112,map02020,map02030,map04112	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_15,AAA_21,DUF4339,TMP_2,Tubulin_2
HFD1_k127_5877731_29	1123059.KB823011_gene1044	7.594e-07	58.0	COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria,2U2MN@28211|Alphaproteobacteria,43X2B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HFD1_k127_5877731_8	234267.Acid_2096	6.137e-149	482.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B0@57723|Acidobacteria	57723|Acidobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19
HFD1_k127_5877731_2	234267.Acid_2095	1.147e-299	927.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD1_k127_5877731_0	234267.Acid_2093	0.0	1933.0	COG1629@1|root,COG4771@2|Bacteria,3Y3A5@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_5877731_24	234267.Acid_2092	1.752e-37	145.0	COG2272@1|root,COG2272@2|Bacteria,3Y3YC@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_5908284_3	234267.Acid_0958	8.784e-66	228.0	COG0801@1|root,COG0801@2|Bacteria,3Y57F@57723|Acidobacteria	57723|Acidobacteria	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HFD1_k127_5908284_0	234267.Acid_0959	1.523e-296	921.0	COG0514@1|root,COG0514@2|Bacteria,3Y2KM@57723|Acidobacteria	57723|Acidobacteria	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RecQ_Zn_bind
HFD1_k127_5908284_1	234267.Acid_3186	6.602e-142	458.0	COG0306@1|root,COG0306@2|Bacteria,3Y3ZW@57723|Acidobacteria	57723|Acidobacteria	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD1_k127_5908284_4	234267.Acid_2270	2.367e-13	70.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5934702_2	1340493.JNIF01000003_gene1851	1.053e-107	362.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD1_k127_5934702_3	234267.Acid_0319	6.954e-89	303.0	COG0705@1|root,COG0705@2|Bacteria,3Y4GU@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HFD1_k127_5934702_1	234267.Acid_2605	1.129e-112	369.0	COG2133@1|root,COG2133@2|Bacteria,3Y3FI@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_5934702_0	234267.Acid_0320	1.2e-147	489.0	COG0235@1|root,COG0235@2|Bacteria,3Y4E0@57723|Acidobacteria	57723|Acidobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD1_k127_5934702_4	234267.Acid_0321	2.236e-47	171.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
HFD1_k127_5934702_6	234267.Acid_0322	1.639e-44	164.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD1_k127_5934702_7	234267.Acid_0323	8.687e-37	143.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD1_k127_5934702_5	234267.Acid_0324	2.096e-46	168.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD1_k127_593613_5	234267.Acid_7269	2.885e-24	103.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD1_k127_593613_7	69395.JQLZ01000002_gene1293	9.447e-15	85.0	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U9RE@28211|Alphaproteobacteria,2KK0D@204458|Caulobacterales	204458|Caulobacterales	S	Retroviral aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HFD1_k127_593613_6	1267534.KB906756_gene350	1.505e-23	117.0	COG0457@1|root,COG3710@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8,Trans_reg_C
HFD1_k127_593613_2	234267.Acid_7679	2.011e-124	424.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_593613_0	278963.ATWD01000001_gene3345	2.05e-262	846.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_593613_4	1163408.UU9_03787	2.137e-57	206.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_593613_8	1265756.AWZW01000008_gene1305	3.069e-06	55.0	2DR6B@1|root,33ACQ@2|Bacteria,1NI4T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_593613_3	517418.Ctha_0318	1.985e-94	318.0	COG1131@1|root,COG1131@2|Bacteria,1FDTT@1090|Chlorobi	2|Bacteria	V	PFAM ABC transporter related	-	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	-	ABC_tran
HFD1_k127_593613_1	886293.Sinac_4981	9.173e-239	769.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,2IXSG@203682|Planctomycetes	203682|Planctomycetes	N	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_5,ABC_transp_aux
HFD1_k127_5948461_0	234267.Acid_4263	2.949e-85	293.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	2|Bacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HFD1_k127_5948461_1	1210884.HG799466_gene12502	3.865e-42	159.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_5951305_5	234267.Acid_7016	1.929e-67	245.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_5951305_2	234267.Acid_7017	9.383e-237	737.0	COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD1_k127_5951305_4	234267.Acid_7018	3.761e-68	235.0	COG0698@1|root,COG0698@2|Bacteria,3Y5FG@57723|Acidobacteria	57723|Acidobacteria	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD1_k127_5951305_1	1340493.JNIF01000003_gene2993	3.471e-251	786.0	COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HFD1_k127_5951305_3	1340493.JNIF01000004_gene757	8.197e-104	363.0	COG5002@1|root,COG5002@2|Bacteria,3Y9FP@57723|Acidobacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_5951305_0	234267.Acid_6585	2.86e-293	924.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_5951305_6	234267.Acid_6585	4.609e-08	59.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_5958334_13	452637.Oter_4270	2.482e-45	168.0	COG4225@1|root,COG5434@1|root,COG4225@2|Bacteria,COG5434@2|Bacteria,46V95@74201|Verrucomicrobia,3K7RU@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_28,Glyco_hydro_88
HFD1_k127_5958334_6	234267.Acid_7443	1.301e-173	550.0	COG0438@1|root,COG0438@2|Bacteria,3Y6A8@57723|Acidobacteria	57723|Acidobacteria	M	Domain of unknown function (DUF1972)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1972,Glyco_trans_1_4
HFD1_k127_5958334_5	234267.Acid_7442	2.826e-205	643.0	COG1216@1|root,COG1216@2|Bacteria,3Y7CJ@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_5958334_11	234267.Acid_7441	2.714e-118	387.0	COG1216@1|root,COG1216@2|Bacteria,3Y7JI@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HFD1_k127_5958334_12	234267.Acid_7440	4.485e-112	375.0	COG1216@1|root,COG1216@2|Bacteria,3Y80R@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_5958334_10	234267.Acid_7439	5.432e-119	385.0	COG1215@1|root,COG1215@2|Bacteria,3Y5K6@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_5958334_0	234267.Acid_7437	0.0	1184.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,3Y79C@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HFD1_k127_5958334_15	1125973.JNLC01000001_gene144	4.456e-34	146.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD1_k127_5958334_3	234267.Acid_7435	1.295e-227	711.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD1_k127_5958334_8	234267.Acid_7731	8.036e-134	452.0	COG2022@1|root,COG2022@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HFD1_k127_5958334_4	234267.Acid_4955	2.552e-210	662.0	COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD1_k127_5958334_1	234267.Acid_7675	0.0	1173.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD1_k127_5958334_2	234267.Acid_7674	5.133e-235	737.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria	57723|Acidobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HFD1_k127_5958334_7	234267.Acid_7671	9.233e-139	445.0	COG1718@1|root,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5958334_18	306281.AJLK01000100_gene3884	9.82e-24	104.0	COG2146@1|root,COG2146@2|Bacteria,1G9AZ@1117|Cyanobacteria,1JM1Y@1189|Stigonemataceae	1117|Cyanobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HFD1_k127_5958334_19	1042375.AFPL01000026_gene3661	2.405e-22	99.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,467XF@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD1_k127_5958334_9	234267.Acid_7670	4.622e-131	423.0	COG0115@1|root,COG0115@2|Bacteria,3Y6HY@57723|Acidobacteria	57723|Acidobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD1_k127_5990337_1	864069.MicloDRAFT_00028220	7.339e-133	427.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1JZ15@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HFD1_k127_5990337_0	224911.27351786	5.513e-230	721.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,3JSZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
HFD1_k127_5992410_0	234267.Acid_0858	0.0	1492.0	COG2010@1|root,COG2010@2|Bacteria,3Y6T1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD1_k127_5992410_1	234267.Acid_0859	2.601e-272	843.0	COG4102@1|root,COG4102@2|Bacteria,3Y6RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_5996027_7	234267.Acid_6898	2.9e-06	55.0	COG3464@1|root,COG3464@2|Bacteria,3Y89T@57723|Acidobacteria	57723|Acidobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
HFD1_k127_5996027_4	1173028.ANKO01000250_gene2391	8.441e-71	271.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HF9F@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_5996027_0	1501230.ET33_29380	4.051e-171	548.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4IJJ5@91061|Bacilli,26V7W@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HFD1_k127_5996027_3	1267535.KB906767_gene4402	1.922e-71	251.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD1_k127_5996027_1	234267.Acid_3915	2.845e-103	341.0	COG0363@1|root,COG0363@2|Bacteria,3Y51I@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
HFD1_k127_5996027_5	1434325.AZQN01000002_gene956	1.651e-58	216.0	COG2010@1|root,COG2010@2|Bacteria,4PMA9@976|Bacteroidetes,47Y99@768503|Cytophagia	976|Bacteroidetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_5996027_2	1089547.KB913013_gene1007	7.057e-87	302.0	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,47NBC@768503|Cytophagia	976|Bacteroidetes	I	3-hydroxyacyl-CoA dehydrogenase NAD-binding	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD1_k127_5996027_6	1123277.KB893174_gene6071	1.861e-50	188.0	COG0697@1|root,COG0697@2|Bacteria,4NHXC@976|Bacteroidetes,47T35@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_5996681_3	671143.DAMO_1046	3.448e-48	177.0	COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria	2|Bacteria	S	ACT domain protein	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
HFD1_k127_5996681_1	1227739.Hsw_0519	2.642e-93	327.0	COG5285@1|root,COG5285@2|Bacteria,4NG3B@976|Bacteroidetes,47N28@768503|Cytophagia	976|Bacteroidetes	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD1_k127_5996681_0	234267.Acid_2809	1.042e-120	391.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD1_k127_5996681_2	234267.Acid_2810	3.394e-65	227.0	COG2128@1|root,COG2128@2|Bacteria,3Y8IA@57723|Acidobacteria	57723|Acidobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_5999303_1	1219375.CM002139_gene1547	2.254e-36	141.0	2C130@1|root,32R80@2|Bacteria,1RDSY@1224|Proteobacteria,1SRF4@1236|Gammaproteobacteria,1X9SA@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD1_k127_5999303_0	1408419.JHYG01000011_gene2602	2.683e-74	269.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TW70@28211|Alphaproteobacteria,2JZ77@204441|Rhodospirillales	204441|Rhodospirillales	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD1_k127_6000071_1	234267.Acid_3353	3.812e-289	897.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria	57723|Acidobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD1_k127_6000071_8	234267.Acid_3352	1.325e-128	421.0	COG0084@1|root,COG0084@2|Bacteria,3Y4DK@57723|Acidobacteria	57723|Acidobacteria	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD1_k127_6000071_4	234267.Acid_3351	1.761e-174	555.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD1_k127_6000071_12	682795.AciX8_4276	6.176e-39	152.0	COG1595@1|root,COG1595@2|Bacteria,3Y87A@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
HFD1_k127_6000071_9	234267.Acid_4096	5.977e-73	253.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_6000071_11	1267533.KB906733_gene2995	4.52e-47	172.0	COG3795@1|root,COG3795@2|Bacteria	2|Bacteria	F	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_6000071_5	234267.Acid_4098	5.985e-164	519.0	COG3186@1|root,COG3186@2|Bacteria,3Y3K5@57723|Acidobacteria	57723|Acidobacteria	E	Biopterin-dependent aromatic amino acid hydroxylase	-	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HFD1_k127_6000071_10	234267.Acid_4100	1.697e-50	183.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD1_k127_6000071_0	234267.Acid_0469	0.0	1164.0	COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria	57723|Acidobacteria	E	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HFD1_k127_6000071_3	234267.Acid_2720	4.149e-233	732.0	COG0624@1|root,COG0624@2|Bacteria,3Y2UM@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_6000071_2	234267.Acid_1183	1.346e-270	846.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD1_k127_6000071_13	234267.Acid_1817	1.07e-14	86.0	COG4206@1|root,COG4206@2|Bacteria,3Y8AK@57723|Acidobacteria	57723|Acidobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_6000071_6	1123278.KB893574_gene6158	7.974e-149	477.0	COG0823@1|root,COG0823@2|Bacteria,4NM2C@976|Bacteroidetes,47NM2@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6000071_7	234267.Acid_1817	1.818e-130	425.0	COG4206@1|root,COG4206@2|Bacteria,3Y8AK@57723|Acidobacteria	57723|Acidobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_6021035_0	234267.Acid_4571	1.064e-91	304.0	COG2268@1|root,COG2268@2|Bacteria,3Y3UJ@57723|Acidobacteria	57723|Acidobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HFD1_k127_6021035_1	234267.Acid_4570	4.63e-88	295.0	COG1842@1|root,COG1842@2|Bacteria,3Y4HA@57723|Acidobacteria	57723|Acidobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HFD1_k127_6021035_2	204669.Acid345_1038	1.029e-26	124.0	COG1216@1|root,COG1807@1|root,COG1216@2|Bacteria,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria,2JJ34@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_6026695_5	234267.Acid_6175	2.795e-52	204.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	BACON,CarboxypepD_reg,DUF11,Lipase_GDSL_2,NPCBM_assoc,PA14,RicinB_lectin_2,VPEP
HFD1_k127_6026695_3	234267.Acid_0043	7.59e-79	269.0	COG2834@1|root,COG2834@2|Bacteria,3Y4XE@57723|Acidobacteria	57723|Acidobacteria	M	outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HFD1_k127_6026695_1	234267.Acid_0044	6.67e-201	633.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD1_k127_6026695_0	234267.Acid_0045	1.215e-321	987.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria	57723|Acidobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HFD1_k127_6026695_2	234267.Acid_0046	6.189e-145	464.0	COG4972@1|root,COG4972@2|Bacteria,3Y4X3@57723|Acidobacteria	57723|Acidobacteria	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD1_k127_6026695_6	401053.AciPR4_3037	2.572e-13	78.0	COG3166@1|root,COG3166@2|Bacteria,3Y4GJ@57723|Acidobacteria,2JJ3Y@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HFD1_k127_6026695_7	234267.Acid_0049	1.454e-12	78.0	2C8FF@1|root,333TN@2|Bacteria,3Y5GA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6045248_4	234267.Acid_6167	7.331e-27	117.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	nreC3	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD1_k127_6045248_5	1300345.LF41_1254	8.665e-06	53.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S24U@1236|Gammaproteobacteria,1X7K5@135614|Xanthomonadales	135614|Xanthomonadales	M	Periplasmic protein TonB links inner and outer membranes	tonB4	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_6045248_0	234267.Acid_7032	5.348e-160	520.0	COG2271@1|root,COG2271@2|Bacteria,3Y3FW@57723|Acidobacteria	57723|Acidobacteria	G	Organic Anion Transporter Polypeptide (OATP) family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_6045248_3	1340493.JNIF01000003_gene4734	5.885e-46	168.0	COG0346@1|root,COG0346@2|Bacteria,3Y8F5@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_6045248_1	234267.Acid_0535	2.124e-114	379.0	COG1554@1|root,COG1554@2|Bacteria,3Y5FD@57723|Acidobacteria	57723|Acidobacteria	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6045933_10	1340493.JNIF01000003_gene3197	1.515e-77	272.0	COG0308@1|root,COG0308@2|Bacteria,3Y6V6@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HFD1_k127_6045933_0	1267535.KB906767_gene5533	0.0	1199.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZU@57723|Acidobacteria,2JHPF@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_6045933_4	1267533.KB906733_gene3362	1.111e-145	488.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_6045933_11	1173028.ANKO01000151_gene5291	1.367e-59	224.0	COG0671@1|root,COG2931@1|root,COG0671@2|Bacteria,COG2931@2|Bacteria,1G3V2@1117|Cyanobacteria,1H9MJ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PAP2
HFD1_k127_6045933_12	234267.Acid_6314	1.03e-39	165.0	COG0454@1|root,COG0456@2|Bacteria,3Y54F@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_6045933_8	536019.Mesop_4520	1.802e-104	362.0	COG0031@1|root,COG0031@2|Bacteria,1Q4JV@1224|Proteobacteria,2VG8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_6045933_2	234267.Acid_3724	5.781e-236	754.0	COG2234@1|root,COG2234@2|Bacteria,3Y4CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_6045933_9	1267535.KB906767_gene4788	1.183e-77	282.0	COG2755@1|root,COG2755@2|Bacteria,3Y4BD@57723|Acidobacteria,2JMAI@204432|Acidobacteriia	204432|Acidobacteriia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD1_k127_6045933_3	234267.Acid_0831	2.371e-185	585.0	COG4733@1|root,COG4733@2|Bacteria,3Y99S@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
HFD1_k127_6045933_5	234267.Acid_7803	6.216e-140	450.0	COG4301@1|root,COG4301@2|Bacteria	2|Bacteria	S	dimethylhistidine N-methyltransferase activity	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
HFD1_k127_6045933_6	234267.Acid_7802	6.804e-130	418.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_6045933_7	234267.Acid_7764	5.275e-120	422.0	COG0673@1|root,COG0673@2|Bacteria,3Y4BF@57723|Acidobacteria	57723|Acidobacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_6045933_1	234267.Acid_7763	0.0	1168.0	COG1200@1|root,COG1200@2|Bacteria,3Y31Z@57723|Acidobacteria	57723|Acidobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD1_k127_6045933_13	234267.Acid_7762	4.897e-33	146.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria	57723|Acidobacteria	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HFD1_k127_6054120_3	234267.Acid_5908	1.381e-08	57.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CHASE,DUF3365,GAF_2,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_6054120_1	269800.Tfu_0620	1.583e-20	94.0	COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria,4EFJ7@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyl hydrolases family 6	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_2,Glyco_hydro_6
HFD1_k127_6054120_4	1121918.ARWE01000001_gene3027	0.0001506	51.0	2FDAJ@1|root,345CF@2|Bacteria,1P36N@1224|Proteobacteria,4314V@68525|delta/epsilon subdivisions,2WX3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6054120_0	1340493.JNIF01000003_gene3435	5.291e-70	252.0	COG1312@1|root,COG1312@2|Bacteria,3Y6UB@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HFD1_k127_6054120_2	1254432.SCE1572_46990	1.655e-16	79.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HFD1_k127_6055996_17	861299.J421_0281	8.04e-18	92.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6055996_15	1267535.KB906767_gene3834	1.32e-37	148.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6055996_0	1340493.JNIF01000003_gene4529	0.0	1305.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6055996_10	234267.Acid_5362	1.906e-76	266.0	COG2976@1|root,COG2976@2|Bacteria,3Y9AW@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HFD1_k127_6055996_2	234267.Acid_5363	4.501e-173	561.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HFD1_k127_6055996_14	1267535.KB906767_gene3171	8.871e-54	198.0	2EGFY@1|root,30MEN@2|Bacteria,3Y7VF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6055996_5	234267.Acid_5365	1.217e-139	452.0	COG1868@1|root,COG1868@2|Bacteria,3Y49R@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
HFD1_k127_6055996_12	234267.Acid_5366	1.082e-59	217.0	COG0745@1|root,COG0745@2|Bacteria,3Y55U@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD1_k127_6055996_11	234267.Acid_5367	1.017e-68	243.0	COG1406@1|root,COG1406@2|Bacteria	2|Bacteria	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
HFD1_k127_6055996_9	234267.Acid_5368	5.614e-83	279.0	COG0835@1|root,COG0835@2|Bacteria,3Y4YS@57723|Acidobacteria	57723|Acidobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HFD1_k127_6055996_7	234267.Acid_1069	1.215e-96	342.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,3Y4VY@57723|Acidobacteria	57723|Acidobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
HFD1_k127_6055996_4	644282.Deba_2782	1.56e-148	492.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HFD1_k127_6055996_6	234267.Acid_5370	2.988e-118	387.0	COG1352@1|root,COG1352@2|Bacteria,3Y4GP@57723|Acidobacteria	57723|Acidobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HFD1_k127_6055996_16	439235.Dalk_0652	1.353e-31	134.0	COG1871@1|root,COG1871@2|Bacteria,1RAWA@1224|Proteobacteria,42QP1@68525|delta/epsilon subdivisions,2WQBY@28221|Deltaproteobacteria,2MJPU@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD1	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HFD1_k127_6055996_3	234267.Acid_5374	3.413e-155	496.0	COG2201@1|root,COG2201@2|Bacteria,3Y35K@57723|Acidobacteria	57723|Acidobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HFD1_k127_6055996_8	330214.NIDE4335	7.176e-93	312.0	COG0708@1|root,COG0708@2|Bacteria,3J13K@40117|Nitrospirae	40117|Nitrospirae	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD1_k127_6055996_13	1122604.JONR01000013_gene3269	2.121e-55	218.0	COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,1RQ2T@1236|Gammaproteobacteria,1XC61@135614|Xanthomonadales	135614|Xanthomonadales	E	Ethanolamine ammonia-lyase light chain (EutC)	-	-	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
HFD1_k127_6055996_1	234267.Acid_3824	5.575e-234	730.0	COG4303@1|root,COG4303@2|Bacteria,3Y65J@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Ethanolamine ammonia lyase large subunit	-	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
HFD1_k127_6055996_18	234267.Acid_3825	2.856e-09	58.0	COG0531@1|root,COG0531@2|Bacteria,3Y6J9@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	-
HFD1_k127_605608_2	1198114.AciX9_2897	3.624e-105	362.0	COG1404@1|root,COG5164@1|root,COG1404@2|Bacteria,COG5164@2|Bacteria,3Y5WB@57723|Acidobacteria,2JK6I@204432|Acidobacteriia	204432|Acidobacteriia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD1_k127_605608_0	1340493.JNIF01000003_gene4593	4.159e-270	857.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HFD1_k127_605608_3	1340493.JNIF01000004_gene309	1.164e-79	277.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_605608_1	234267.Acid_2658	6.082e-215	672.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria	2|Bacteria	G	BNR repeat-like domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	BNR_2
HFD1_k127_605608_6	309801.trd_A0832	1.744e-10	63.0	COG2331@1|root,COG2331@2|Bacteria,2G7IB@200795|Chloroflexi	200795|Chloroflexi	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD1_k127_605608_4	234267.Acid_7855	6.695e-77	265.0	COG2323@1|root,COG2323@2|Bacteria,3Y4R1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HFD1_k127_605608_5	234267.Acid_7856	1.269e-65	226.0	COG0305@1|root,COG0305@2|Bacteria,3Y335@57723|Acidobacteria	57723|Acidobacteria	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD1_k127_6056107_1	234267.Acid_6378	4.441e-220	698.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria	57723|Acidobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD1_k127_6056107_7	1267534.KB906755_gene4322	4.396e-89	305.0	COG2133@1|root,COG2133@2|Bacteria,3Y7GQ@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_6056107_2	234267.Acid_2458	5.563e-180	568.0	COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria	57723|Acidobacteria	H	PFAM delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HFD1_k127_6056107_10	1218075.BAYA01000049_gene6768	3.022e-30	138.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VIZX@28216|Betaproteobacteria,1KIJ5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
HFD1_k127_6056107_9	441620.Mpop_0172	6.698e-63	239.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,1NWNJ@1224|Proteobacteria,2U3RV@28211|Alphaproteobacteria,1JXED@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HWE_HK,PAS,PAS_3,PAS_4
HFD1_k127_6056107_13	321846.PS417_13910	6.079e-22	100.0	COG0784@1|root,COG0784@2|Bacteria,1P8D2@1224|Proteobacteria	1224|Proteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_6056107_0	234267.Acid_2483	7.122e-227	710.0	COG0172@1|root,COG0172@2|Bacteria,3Y2UD@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD1_k127_6056107_8	234267.Acid_2482	2.278e-67	232.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_6056107_4	234267.Acid_2479	4.727e-127	434.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_6056107_11	234267.Acid_2478	3.507e-30	121.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HFD1_k127_6056107_5	234267.Acid_4147	2.749e-93	329.0	COG0545@1|root,COG2318@1|root,COG0545@2|Bacteria,COG2318@2|Bacteria,3Y5E0@57723|Acidobacteria	57723|Acidobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD1_k127_6056107_6	234267.Acid_4729	3.743e-91	308.0	COG0457@1|root,COG0457@2|Bacteria,3Y7Q5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HFD1_k127_6056107_12	477641.MODMU_4636	1.7e-28	118.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERZ0@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_6063616_0	234267.Acid_0535	2.958e-249	780.0	COG1554@1|root,COG1554@2|Bacteria,3Y5FD@57723|Acidobacteria	57723|Acidobacteria	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6063616_1	234267.Acid_5623	1.382e-205	644.0	COG4948@1|root,COG4948@2|Bacteria,3Y6CG@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, N-terminal domain protein	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_6072336_1	234267.Acid_6644	5.376e-152	490.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HFD1_k127_6072336_3	234267.Acid_6643	3.286e-30	124.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ANAPC5,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
HFD1_k127_6072336_5	861299.J421_5728	1.926e-27	117.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1ZUC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HFD1_k127_6072336_4	234267.Acid_6641	4.064e-29	117.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD1_k127_6072336_0	234267.Acid_2509	9.642e-293	920.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HFD1_k127_6072336_2	234267.Acid_0540	1.261e-39	150.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HFD1_k127_6075143_2	211165.AJLN01000134_gene5775	1.559e-15	80.0	COG0179@1|root,COG0179@2|Bacteria,1G2C6@1117|Cyanobacteria,1JJVS@1189|Stigonemataceae	1117|Cyanobacteria	Q	Fumarylacetoacetase N-terminal	-	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HFD1_k127_6075143_1	234267.Acid_6517	5.052e-52	193.0	COG0124@1|root,COG0124@2|Bacteria,3Y4H5@57723|Acidobacteria	57723|Acidobacteria	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6075143_3	234267.Acid_6770	4.878e-12	79.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,3Y77J@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_11,TPR_16
HFD1_k127_6075143_0	414684.RC1_0774	6.676e-59	216.0	COG2120@1|root,COG2120@2|Bacteria,1RJX0@1224|Proteobacteria,2UA4M@28211|Alphaproteobacteria,2JXQF@204441|Rhodospirillales	204441|Rhodospirillales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_6082772_3	105559.Nwat_3192	5.58e-27	112.0	COG3549@1|root,COG3549@2|Bacteria	105559.Nwat_3192|-	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	-
HFD1_k127_6082772_2	105559.Nwat_3191	2.614e-32	130.0	COG3093@1|root,COG3093@2|Bacteria,1N6H7@1224|Proteobacteria,1SDVB@1236|Gammaproteobacteria,1X26B@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD1_k127_6082772_4	234267.Acid_2528	6.366e-07	60.0	COG4372@1|root,COG4372@2|Bacteria	2|Bacteria	Q	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,zf-IS66
HFD1_k127_6082772_0	234267.Acid_2500	1.045e-160	513.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3Y4I2@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HFD1_k127_6082772_1	1382359.JIAL01000001_gene1872	3.98e-40	154.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_6084212_1	234267.Acid_6305	6.229e-27	114.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	Z012_09690	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_6084212_0	234267.Acid_6304	1.459e-105	350.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD1_k127_6084212_2	401526.TcarDRAFT_0607	1.772e-17	93.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4H4XS@909932|Negativicutes	909932|Negativicutes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
HFD1_k127_6105412_1	1410620.SHLA_36c000140	1.052e-112	389.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_6105412_0	682795.AciX8_0849	7.544e-176	565.0	COG0477@1|root,COG0477@2|Bacteria,3Y428@57723|Acidobacteria,2JIYF@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HFD1_k127_6105412_3	234267.Acid_7487	2.628e-63	228.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HFD1_k127_6105412_2	234267.Acid_6663	2.988e-73	254.0	COG1649@1|root,COG1874@1|root,COG1649@2|Bacteria,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL10,GHL6,Glyco_hydro_42,Glyco_hydro_42M,Polysacc_deac_1
HFD1_k127_6131707_1	420662.Mpe_A3442	1.247e-101	334.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,1KJ71@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD1_k127_6131707_2	511.JT27_05805	4.004e-34	141.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,3T478@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD1_k127_6131707_0	1003200.AXXA_10138	4.134e-132	423.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,3T1RW@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD1_k127_6138912_1	234267.Acid_6694	1.966e-131	424.0	2E98K@1|root,333GZ@2|Bacteria,3Y55V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6138912_2	1267535.KB906767_gene1698	1.004e-60	227.0	COG3794@1|root,COG3794@2|Bacteria,3Y4UD@57723|Acidobacteria,2JJH0@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6138912_0	234267.Acid_6692	3.842e-246	774.0	COG4191@1|root,COG4191@2|Bacteria,3Y4SZ@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
HFD1_k127_6147326_3	1348663.KCH_28830	4.421e-36	139.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,2M1R1@2063|Kitasatospora	201174|Actinobacteria	C	Pyruvate formate lyase-like	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HFD1_k127_6147326_0	1267534.KB906761_gene1193	5.418e-178	565.0	COG0282@1|root,COG0282@2|Bacteria,3Y3Y4@57723|Acidobacteria,2JI6D@204432|Acidobacteriia	57723|Acidobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HFD1_k127_6147326_1	1267534.KB906761_gene1194	6.756e-135	443.0	COG0280@1|root,COG0280@2|Bacteria,3Y4QI@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HFD1_k127_6147326_2	1449049.JONW01000005_gene1183	3.291e-45	167.0	COG2271@1|root,COG2271@2|Bacteria,1RGKJ@1224|Proteobacteria,2TV2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_6160976_1	452637.Oter_1828	5.401e-05	46.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6160976_0	234267.Acid_3816	0.0	1610.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3Y2JQ@57723|Acidobacteria	57723|Acidobacteria	E	glutamate synthase alpha subunit	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD1_k127_6165960_3	234267.Acid_4600	1.866e-40	162.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_6165960_1	234267.Acid_4601	2.204e-167	530.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD1_k127_6165960_2	1316936.K678_12252	4.317e-65	239.0	COG2220@1|root,COG2220@2|Bacteria,1NNZA@1224|Proteobacteria,2U6PV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Beta-lactamase superfamily domain	-	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,Lactamase_B_2,Lactamase_B_3
HFD1_k127_6165960_0	234267.Acid_5075	6.963e-197	627.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K08307,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	LysM,Peptidase_M23,SLT
HFD1_k127_6186390_0	448385.sce8050	4.304e-215	681.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
HFD1_k127_6186390_1	234267.Acid_2336	1.81e-103	342.0	COG1028@1|root,COG1028@2|Bacteria,3Y2JR@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD1_k127_6186390_4	234267.Acid_7902	1.026e-64	239.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,Reg_prop,TPR_12,Y_Y_Y
HFD1_k127_6186390_2	234267.Acid_7901	3.969e-92	315.0	COG2197@1|root,COG2197@2|Bacteria,3Y8CY@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_6186390_3	234267.Acid_7898	1.337e-68	237.0	COG5483@1|root,COG5483@2|Bacteria,3Y4X5@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD1_k127_6186390_5	234267.Acid_2629	2.486e-46	188.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6186390_9	234267.Acid_6567	9.281e-18	91.0	COG0826@1|root,COG0826@2|Bacteria,3Y7M5@57723|Acidobacteria	57723|Acidobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HFD1_k127_6186390_10	234267.Acid_7901	0.000132	48.0	COG2197@1|root,COG2197@2|Bacteria,3Y8CY@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_6186390_8	234267.Acid_7898	2.676e-31	131.0	COG5483@1|root,COG5483@2|Bacteria,3Y4X5@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD1_k127_6192124_7	702438.HMPREF9431_00759	2.077e-05	52.0	COG1403@1|root,COG1403@2|Bacteria,4PBA0@976|Bacteroidetes,2FYQP@200643|Bacteroidia	976|Bacteroidetes	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6192124_0	177437.HRM2_26400	1.338e-109	370.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2MPWR@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
HFD1_k127_6192124_5	639030.JHVA01000001_gene3782	1.952e-06	52.0	COG5378@1|root,COG5378@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_2
HFD1_k127_6192124_1	1432050.IE4771_CH03355	1.74e-23	103.0	2E46S@1|root,32Z2Q@2|Bacteria,1N7X1@1224|Proteobacteria,2V2ZJ@28211|Alphaproteobacteria,4BJWR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6192124_6	1537715.JQFJ01000005_gene26	2.799e-06	53.0	2AC5S@1|root,311Q7@2|Bacteria,1PPSI@1224|Proteobacteria,2UKJM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HFD1_k127_6192124_3	1123296.JQKE01000007_gene479	1.99e-08	61.0	COG3668@1|root,COG3668@2|Bacteria,1N7G9@1224|Proteobacteria,2VTCI@28216|Betaproteobacteria,2KS6V@206351|Neisseriales	206351|Neisseriales	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HFD1_k127_6192124_2	1144310.PMI07_001793	1.945e-16	85.0	COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,2UJK3@28211|Alphaproteobacteria,4BHQ1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HFD1_k127_6192124_4	1267535.KB906767_gene2326	8.59e-07	55.0	COG2929@1|root,COG3514@1|root,COG2929@2|Bacteria,COG3514@2|Bacteria	2|Bacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnA_antitoxin,BrnT_toxin
HFD1_k127_6214814_2	1121468.AUBR01000001_gene574	2.539e-78	270.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,42J26@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
HFD1_k127_6214814_1	234267.Acid_6255	2.975e-92	305.0	COG0262@1|root,COG0262@2|Bacteria,3Y4A4@57723|Acidobacteria	57723|Acidobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD1_k127_6214814_5	234267.Acid_6254	4.113e-62	214.0	COG4898@1|root,COG4898@2|Bacteria,3Y842@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
HFD1_k127_6214814_3	234267.Acid_3868	3.454e-72	249.0	COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HFD1_k127_6214814_4	1267534.KB906754_gene3368	1.208e-71	243.0	COG5649@1|root,COG5649@2|Bacteria,3Y4QH@57723|Acidobacteria,2JMZM@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_6214814_0	234267.Acid_3043	2.025e-246	766.0	COG3055@1|root,COG3055@2|Bacteria,3Y6HA@57723|Acidobacteria	2|Bacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF5060,Kelch_1,Kelch_6,Malectin,NPCBM
HFD1_k127_6222666_4	1380370.JIBA01000011_gene3139	0.0001124	47.0	COG0697@1|root,COG0697@2|Bacteria,2GNSA@201174|Actinobacteria,4FFJ5@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_6222666_1	1121920.AUAU01000005_gene1059	7.682e-32	135.0	2B9NZ@1|root,3231D@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
HFD1_k127_6222666_0	504472.Slin_4508	6.358e-83	293.0	28PE3@1|root,2ZC5W@2|Bacteria,4NRIC@976|Bacteroidetes,47QXH@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4932
HFD1_k127_6222666_3	278963.ATWD01000001_gene1575	3.538e-08	63.0	COG1555@1|root,COG1555@2|Bacteria,3Y8EF@57723|Acidobacteria,2JNFN@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HFD1_k127_6222666_2	306281.AJLK01000189_gene1808	4.561e-27	118.0	COG2898@1|root,COG2898@2|Bacteria,1G1E7@1117|Cyanobacteria	1117|Cyanobacteria	S	conserved protein (DUF2156)	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,tRNA-synt_2_TM
HFD1_k127_6223940_4	234267.Acid_5675	6.673e-31	124.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria	57723|Acidobacteria	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD1_k127_6223940_2	234267.Acid_6096	1.017e-89	306.0	28ZWN@1|root,2ZMM4@2|Bacteria,3Y8RZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6223940_1	234267.Acid_5206	3.425e-109	370.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_6223940_0	234267.Acid_1348	1.927e-123	401.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD1_k127_6223940_3	861299.J421_5960	1.009e-42	164.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6259674_4	1340493.JNIF01000004_gene207	7.983e-46	171.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_6259674_1	234267.Acid_5819	2.138e-272	847.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD1_k127_6259674_2	234267.Acid_5820	3.629e-253	792.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD1_k127_6259674_0	234267.Acid_5821	7.874e-283	888.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria	57723|Acidobacteria	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
HFD1_k127_6259674_3	234267.Acid_3529	9.24e-60	224.0	COG0169@1|root,COG0169@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K00014,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HFD1_k127_6261162_1	234267.Acid_2826	1.397e-46	173.0	COG0537@1|root,COG0537@2|Bacteria,3Y542@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HFD1_k127_6261162_2	234267.Acid_2827	1.996e-46	173.0	COG1826@1|root,COG1826@2|Bacteria,3Y5TY@57723|Acidobacteria	57723|Acidobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD1_k127_6261162_0	234267.Acid_2828	1.428e-95	320.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria	57723|Acidobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD1_k127_6284079_3	234267.Acid_7409	8.833e-67	231.0	COG0438@1|root,COG0438@2|Bacteria,3Y68S@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_6284079_2	234267.Acid_7408	5.515e-130	422.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,HTH_8,Sigma54_activat,Yop-YscD_cpl
HFD1_k127_6284079_4	234267.Acid_7407	8.417e-64	228.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,3Y4FC@57723|Acidobacteria	57723|Acidobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD1_k127_6284079_7	1267535.KB906767_gene5037	5.818e-31	125.0	COG1695@1|root,COG1695@2|Bacteria,3Y7XS@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_6284079_5	1340493.JNIF01000003_gene2975	3.743e-62	222.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_6284079_6	234267.Acid_7404	1.01e-32	139.0	2FIG5@1|root,34A8B@2|Bacteria,3Y8GN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6284079_1	234267.Acid_7403	2.788e-133	451.0	COG0479@1|root,COG0479@2|Bacteria,3Y3XR@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HFD1_k127_6284079_0	234267.Acid_7402	0.0	1004.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria	57723|Acidobacteria	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD1_k127_6288006_5	1340493.JNIF01000003_gene2751	4.875e-29	126.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543,ko:K16922	-	M00701	-	-	ko00000,ko00002,ko01002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,GbpC,Gram_pos_anchor,HlyD_3,YSIRK_signal
HFD1_k127_6288006_3	1126627.BAWE01000002_gene898	2.698e-108	359.0	COG4249@1|root,COG4249@2|Bacteria,1MY9I@1224|Proteobacteria,2U5UU@28211|Alphaproteobacteria,3K2A3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD1_k127_6288006_1	1126627.BAWE01000002_gene899	3.601e-239	769.0	COG4995@1|root,COG4995@2|Bacteria,1R0B4@1224|Proteobacteria,2UEUK@28211|Alphaproteobacteria,3K09D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD1_k127_6288006_2	1038859.AXAU01000002_gene255	4.606e-190	603.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria,3JTS9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_6288006_0	1047013.AQSP01000126_gene2740	0.0	1078.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD1_k127_6288006_4	234267.Acid_5634	1.574e-47	196.0	COG0823@1|root,COG4447@1|root,COG0823@2|Bacteria,COG4447@2|Bacteria,3Y9AF@57723|Acidobacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Peptidase_S8,SBBP
HFD1_k127_6291130_1	234267.Acid_3450	6.238e-49	179.0	COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_6291130_0	1123278.KB893574_gene6154	2.166e-144	464.0	COG2173@1|root,COG2173@2|Bacteria	2|Bacteria	M	zinc D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15,SH3_3,SH3_4,VanY
HFD1_k127_6295690_11	218284.CCDN010000001_gene572	4.587e-05	56.0	COG1807@1|root,COG1807@2|Bacteria,1TR0R@1239|Firmicutes,4HBI2@91061|Bacilli,1ZET9@1386|Bacillus	91061|Bacilli	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_6295690_7	215803.DB30_1906	4.303e-42	174.0	COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,439T1@68525|delta/epsilon subdivisions,2X563@28221|Deltaproteobacteria,2Z05Z@29|Myxococcales	28221|Deltaproteobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
HFD1_k127_6295690_9	234267.Acid_0739	9.631e-18	97.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	NHL
HFD1_k127_6295690_2	234267.Acid_7394	3.414e-213	682.0	COG3345@1|root,COG3345@2|Bacteria,3Y8BZ@57723|Acidobacteria	57723|Acidobacteria	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
HFD1_k127_6295690_1	234267.Acid_5783	9.699e-311	961.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD1_k127_6295690_8	234267.Acid_5392	4.867e-36	143.0	2CTSB@1|root,32SU2@2|Bacteria,3Y567@57723|Acidobacteria	57723|Acidobacteria	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6295690_0	234267.Acid_5391	0.0	1602.0	COG2609@1|root,COG2609@2|Bacteria,3Y2M3@57723|Acidobacteria	57723|Acidobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD1_k127_6295690_3	234267.Acid_5390	2.953e-122	398.0	COG0053@1|root,COG0053@2|Bacteria,3Y6ZG@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD1_k127_6295690_4	234267.Acid_1081	2.259e-114	373.0	COG2326@1|root,COG2326@2|Bacteria,3Y44F@57723|Acidobacteria	57723|Acidobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HFD1_k127_6295690_6	234267.Acid_7545	2.324e-47	184.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
HFD1_k127_6295690_5	234267.Acid_1082	6.078e-73	250.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria	57723|Acidobacteria	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD1_k127_6299548_1	1340493.JNIF01000004_gene78	8.433e-51	196.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD1_k127_6299548_0	234267.Acid_4698	7.153e-285	890.0	COG0405@1|root,COG0405@2|Bacteria,3Y6KV@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD1_k127_6299548_2	234267.Acid_2515	6.691e-12	65.0	COG0075@1|root,COG0075@2|Bacteria,3Y2Q8@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_6306780_3	234267.Acid_6303	2.465e-06	49.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria	57723|Acidobacteria	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HFD1_k127_6306780_0	234267.Acid_6302	9.206e-160	508.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_6306780_1	234267.Acid_0433	2.228e-97	346.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_6306780_2	661478.OP10G_4294	3.908e-67	236.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HFD1_k127_6310035_0	1267534.KB906757_gene1065	0.0	1333.0	COG3250@1|root,COG3250@2|Bacteria,3Y455@57723|Acidobacteria,2JHYM@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_6322260_1	234267.Acid_5892	1.279e-104	344.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
HFD1_k127_6322260_0	234267.Acid_5899	3.633e-193	617.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria	57723|Acidobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HFD1_k127_6322260_4	240015.ACP_0091	7.003e-28	117.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_6322260_6	240015.ACP_0092	9.435e-19	88.0	2C5NQ@1|root,2ZVT0@2|Bacteria	2|Bacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HFD1_k127_6322260_2	234267.Acid_6847	6.01e-80	271.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_6322260_3	234267.Acid_5903	2.612e-72	257.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_6322260_5	234267.Acid_5904	4.004e-25	108.0	28VY2@1|root,2ZHZA@2|Bacteria,3Y90R@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6356542_14	1340493.JNIF01000004_gene6	1.394e-27	117.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD1_k127_6356542_16	1340493.JNIF01000003_gene4448	1.522e-10	69.0	COG5267@1|root,COG5492@1|root,COG5267@2|Bacteria,COG5492@2|Bacteria,3Y6EE@57723|Acidobacteria	57723|Acidobacteria	N	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD1_k127_6356542_17	1007104.SUS17_3348	1.312e-08	61.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2U42R@28211|Alphaproteobacteria,2K2MK@204457|Sphingomonadales	204457|Sphingomonadales	S	Tat pathway signal protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_6356542_1	234267.Acid_5992	1.636e-174	554.0	COG0842@1|root,COG0842@2|Bacteria,3Y73W@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_6356542_2	234267.Acid_5991	3.928e-172	549.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_6356542_5	234267.Acid_5990	1.864e-152	486.0	COG1131@1|root,COG1131@2|Bacteria,3Y3VU@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_6356542_9	1340493.JNIF01000003_gene2589	7.145e-88	314.0	COG1131@1|root,COG1131@2|Bacteria,3Y725@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_6356542_3	234267.Acid_5988	3.161e-163	524.0	COG1566@1|root,COG1566@2|Bacteria,3Y53G@57723|Acidobacteria	57723|Acidobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD1_k127_6356542_4	234267.Acid_5987	1.059e-160	524.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_6356542_13	234267.Acid_5986	2.767e-59	211.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	psrA	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD1_k127_6356542_6	234267.Acid_5984	1.149e-137	442.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HFD1_k127_6356542_11	234267.Acid_6217	3.86e-81	281.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD1_k127_6356542_8	401053.AciPR4_2834	2.352e-90	312.0	COG3488@1|root,COG3488@2|Bacteria,3Y3DB@57723|Acidobacteria,2JK0S@204432|Acidobacteriia	204432|Acidobacteriia	C	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HFD1_k127_6356542_12	1340493.JNIF01000003_gene3517	5.271e-77	283.0	COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_6356542_7	1267535.KB906767_gene5422	1.661e-106	372.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,3Y4NJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_6356542_10	234267.Acid_1868	2.262e-86	299.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD1_k127_6356542_0	234267.Acid_1870	6.489e-185	586.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	POR,TPP_enzyme_C
HFD1_k127_635675_3	234267.Acid_7847	3.963e-157	499.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD1_k127_635675_6	278963.ATWD01000001_gene2171	4.131e-06	53.0	COG0745@1|root,COG2198@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,3Y58E@57723|Acidobacteria,2JJU1@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt,Response_reg
HFD1_k127_635675_0	234267.Acid_0508	1.091e-271	844.0	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria	57723|Acidobacteria	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HFD1_k127_635675_4	1267535.KB906767_gene2358	2.534e-52	186.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_635675_2	1267535.KB906767_gene3131	7.511e-159	535.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_635675_1	1267535.KB906767_gene99	2.803e-223	698.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria,2JIAE@204432|Acidobacteriia	204432|Acidobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD1_k127_6374152_7	378806.STAUR_6894	4.994e-95	329.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_6374152_13	450851.PHZ_c2693	0.0009212	51.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,2KH42@204458|Caulobacterales	204458|Caulobacterales	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16
HFD1_k127_6374152_5	1267535.KB906767_gene369	5.658e-120	394.0	COG2017@1|root,COG2017@2|Bacteria,3Y61R@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6374152_4	1267535.KB906767_gene4836	1.141e-126	425.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene4836|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6374152_10	502347.ESCAB7627_3762	5.523e-34	143.0	COG2186@1|root,COG2186@2|Bacteria,1RBCJ@1224|Proteobacteria,1SDYA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD1_k127_6374152_3	1267535.KB906767_gene738	1.199e-134	472.0	COG1629@1|root,COG1629@2|Bacteria,3Y3KT@57723|Acidobacteria,2JI2M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6374152_0	278963.ATWD01000002_gene812	5.207e-249	784.0	COG4993@1|root,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria,2JKX4@204432|Acidobacteriia	204432|Acidobacteriia	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ
HFD1_k127_6374152_11	234267.Acid_2050	4.159e-27	126.0	COG1555@1|root,COG1555@2|Bacteria,3Y869@57723|Acidobacteria	57723|Acidobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD1_k127_6374152_8	1449049.JONW01000007_gene4017	2.833e-61	225.0	293CH@1|root,2ZQV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_6374152_2	234267.Acid_3489	1.138e-160	521.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria	57723|Acidobacteria	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
HFD1_k127_6374152_1	234267.Acid_3989	2.14e-179	568.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD1_k127_6374152_9	234267.Acid_3528	2.891e-47	173.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD1_k127_6377613_3	65393.PCC7424_4909	1.186e-174	566.0	COG1100@1|root,COG1611@1|root,COG4886@1|root,COG1100@2|Bacteria,COG1611@2|Bacteria,COG4886@2|Bacteria,1G05B@1117|Cyanobacteria,3KFNC@43988|Cyanothece	1117|Cyanobacteria	S	Leucine-rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	COR,LRR_4,LRR_8,Roc
HFD1_k127_6377613_5	489825.LYNGBM3L_70420	8.9e-41	170.0	COG1100@1|root,COG4886@1|root,COG1100@2|Bacteria,COG4886@2|Bacteria,1G05B@1117|Cyanobacteria,1H6Y6@1150|Oscillatoriales	1117|Cyanobacteria	S	COG4886 Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	COR,LRR_4,LRR_8,Roc,TIR_2
HFD1_k127_6377613_1	234267.Acid_1375	1.07e-222	698.0	COG0738@1|root,COG0738@2|Bacteria,3Y324@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major facilitator superfamily	-	-	-	ko:K02429	-	-	-	-	ko00000,ko02000	2.A.1.7	-	-	MFS_1
HFD1_k127_6377613_6	671143.DAMO_0428	1.438e-29	126.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
HFD1_k127_6377613_0	234267.Acid_1826	2.136e-271	850.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD1_k127_6377613_2	234267.Acid_1831	1.879e-206	652.0	COG2234@1|root,COG2234@2|Bacteria,3Y43U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_6377613_4	234267.Acid_6155	9.295e-79	265.0	28KEJ@1|root,2ZA0T@2|Bacteria,3Y65Q@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6419833_1	234267.Acid_3825	2.564e-247	769.0	COG0531@1|root,COG0531@2|Bacteria,3Y6J9@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	-
HFD1_k127_6419833_5	234267.Acid_1430	3.74e-78	263.0	COG0789@1|root,COG0789@2|Bacteria,3Y5EZ@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD1_k127_6419833_0	234267.Acid_1428	6.709e-253	807.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_6419833_4	234267.Acid_1426	1.3e-98	333.0	COG2885@1|root,COG2885@2|Bacteria,3Y425@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_6419833_2	234267.Acid_1423	7.229e-145	474.0	COG3267@1|root,COG3267@2|Bacteria,3Y6KP@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD1_k127_6419833_3	234267.Acid_1422	5.097e-105	343.0	COG0290@1|root,COG0290@2|Bacteria,3Y3VP@57723|Acidobacteria	57723|Acidobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HFD1_k127_6419833_6	234267.Acid_3774	6.047e-38	146.0	COG2202@1|root,COG2204@1|root,COG3437@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3Y78F@57723|Acidobacteria	2|Bacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	1.8.1.9,2.7.13.3,3.4.21.53	ko:K00384,ko:K01338,ko:K11527	ko00450,ko04112,map00450,map04112	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko01001,ko01002,ko02022	-	-	-	HATPase_c,HTH_8,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_6451999_1	1122599.AUGR01000015_gene2618	6.901e-05	54.0	28KW6@1|root,2ZACJ@2|Bacteria,1P3A4@1224|Proteobacteria,1RQDW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6451999_0	1121920.AUAU01000033_gene2765	2.739e-69	240.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,3Y6AK@57723|Acidobacteria	57723|Acidobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_6454141_1	234267.Acid_7752	3.761e-192	606.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD1_k127_6454141_3	234267.Acid_7753	3.89e-114	376.0	COG3745@1|root,COG3745@2|Bacteria	2|Bacteria	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD1_k127_6454141_2	234267.Acid_7754	4.635e-179	571.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
HFD1_k127_6454141_9	234267.Acid_7755	2.179e-20	91.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
HFD1_k127_6454141_4	234267.Acid_7756	1.951e-97	330.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7756|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6454141_5	234267.Acid_7757	8.708e-52	184.0	COG1430@1|root,COG1430@2|Bacteria,3Y5J5@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD1_k127_6454141_8	682795.AciX8_3052	3.36e-23	109.0	COG3595@1|root,COG3595@2|Bacteria,3Y4HG@57723|Acidobacteria,2JJ7G@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD1_k127_6454141_12	1005395.CSV86_27127	2.06e-15	81.0	2EHXM@1|root,33BP4@2|Bacteria,1NGZB@1224|Proteobacteria,1STAC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3606)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3606
HFD1_k127_6454141_11	234267.Acid_7949	2.466e-17	84.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	PHD_like
HFD1_k127_6454141_6	234267.Acid_7793	1.971e-33	132.0	COG1598@1|root,COG1598@2|Bacteria,3Y5U6@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6454141_7	234267.Acid_7792	8.123e-32	126.0	COG1724@1|root,COG1724@2|Bacteria,3Y5Y9@57723|Acidobacteria	57723|Acidobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD1_k127_6454141_0	324057.Pjdr2_2000	1.375e-240	762.0	COG1472@1|root,COG4099@1|root,COG1472@2|Bacteria,COG4099@2|Bacteria,1TP0T@1239|Firmicutes,4HCAH@91061|Bacilli,26UB5@186822|Paenibacillaceae	91061|Bacilli	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Glyco_hydro_3,Glyco_hydro_3_C
HFD1_k127_6462790_1	234267.Acid_5944	8.628e-72	247.0	COG0046@1|root,COG0046@2|Bacteria,3Y30N@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_6462790_0	234267.Acid_5943	5.115e-122	394.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD1_k127_6462790_2	1267535.KB906767_gene1390	1.335e-11	74.0	2E1AY@1|root,32WQW@2|Bacteria,3Y8WG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6471391_1	1340493.JNIF01000003_gene3109	5.45e-151	487.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_6471391_2	234267.Acid_6645	3.577e-134	437.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6471391_0	234267.Acid_0882	4.961e-241	750.0	COG0154@1|root,COG0154@2|Bacteria,3Y2N6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD1_k127_6471957_5	1267535.KB906767_gene2036	4.777e-09	57.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
HFD1_k127_6471957_0	234267.Acid_1085	9.506e-165	527.0	COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria	57723|Acidobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD1_k127_6471957_1	234267.Acid_1084	4.989e-162	515.0	COG0280@1|root,COG0280@2|Bacteria,3Y6AD@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HFD1_k127_6471957_2	234267.Acid_7011	9.129e-160	512.0	COG0628@1|root,COG0628@2|Bacteria,3Y4N5@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_6471957_4	234267.Acid_7012	1.045e-64	226.0	COG0816@1|root,COG0816@2|Bacteria,3Y59A@57723|Acidobacteria	57723|Acidobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD1_k127_6471957_3	234267.Acid_7013	1.015e-118	400.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD1_k127_6476898_1	234267.Acid_5244	2.987e-42	171.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	CcmA5	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_6476898_0	1192034.CAP_8743	2.112e-167	543.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HFD1_k127_6480145_10	234267.Acid_0112	5.302e-61	210.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD1_k127_6480145_1	234267.Acid_0113	5.425e-270	832.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HFD1_k127_6480145_0	234267.Acid_0114	0.0	1211.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria	57723|Acidobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HFD1_k127_6480145_6	234267.Acid_0115	3.394e-210	658.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD1_k127_6480145_9	234267.Acid_0116	3.278e-67	232.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria	57723|Acidobacteria	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD1_k127_6480145_12	234267.Acid_0117	1.714e-45	174.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD1_k127_6480145_3	1267535.KB906767_gene4288	8.468e-256	801.0	COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria,2JIG7@204432|Acidobacteriia	204432|Acidobacteriia	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HFD1_k127_6480145_2	234267.Acid_0119	4.121e-263	821.0	COG1008@1|root,COG1008@2|Bacteria,3Y312@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD1_k127_6480145_4	234267.Acid_0120	5.689e-233	729.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD1_k127_6480145_8	204669.Acid345_3766	2.301e-129	427.0	COG0312@1|root,COG0312@2|Bacteria,3Y7SM@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD1_k127_6480145_7	204669.Acid345_3767	2.033e-193	622.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD1_k127_6480145_5	234267.Acid_0546	2.259e-229	717.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_6480145_13	1242864.D187_001430	1.07e-44	178.0	COG2730@1|root,COG3170@1|root,COG2730@2|Bacteria,COG3170@2|Bacteria,1R3TU@1224|Proteobacteria,430KW@68525|delta/epsilon subdivisions,2WVZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Astacin (Peptidase family M12A)	-	-	-	-	-	-	-	-	-	-	-	-	Astacin
HFD1_k127_6480145_11	1340493.JNIF01000003_gene4476	6.08e-52	200.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K07004,ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	ASH,CHU_C,DUF11,SGL
HFD1_k127_6480145_14	234267.Acid_7336	1.276e-41	153.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD1_k127_6488461_13	886293.Sinac_6838	0.0001123	48.0	296HQ@1|root,2ZTT7@2|Bacteria,2J4NZ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6488461_2	234267.Acid_2421	7.558e-158	503.0	COG1319@1|root,COG1319@2|Bacteria,3Y3NU@57723|Acidobacteria	57723|Acidobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD1_k127_6488461_0	234267.Acid_2420	1.168e-311	969.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD1_k127_6488461_6	234267.Acid_2419	2.341e-94	314.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
HFD1_k127_6488461_11	234267.Acid_2717	4.049e-17	83.0	28TDW@1|root,2ZFN7@2|Bacteria,3Y8WA@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6488461_8	234267.Acid_2716	3.379e-58	207.0	2FERC@1|root,346QE@2|Bacteria,3Y8RE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6488461_3	234267.Acid_2715	5.665e-126	411.0	COG1988@1|root,COG1988@2|Bacteria,3Y305@57723|Acidobacteria	57723|Acidobacteria	S	membrane-bound metal-dependent hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HFD1_k127_6488461_12	234267.Acid_2714	1.135e-10	68.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt,Response_reg
HFD1_k127_6488461_10	234267.Acid_3437	1.436e-46	179.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD1_k127_6488461_5	234267.Acid_4912	1.147e-95	329.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_6488461_4	234267.Acid_2223	2.985e-115	389.0	COG1028@1|root,COG1028@2|Bacteria,3Y2RU@57723|Acidobacteria	57723|Acidobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD1_k127_6488461_1	234267.Acid_3371	2.608e-189	601.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_6488461_9	1170562.Cal6303_2679	6.66e-54	193.0	COG5263@1|root,COG5263@2|Bacteria,1G1AI@1117|Cyanobacteria,1HRXU@1161|Nostocales	1117|Cyanobacteria	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	SLH,WG_beta_rep
HFD1_k127_6491255_0	234267.Acid_1291	0.0	1392.0	COG1048@1|root,COG1048@2|Bacteria,3Y34Q@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HFD1_k127_6491255_2	234267.Acid_1290	2.023e-129	432.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	DNA_alkylation,HEAT_2,MFS_1,cNMP_binding
HFD1_k127_6491255_1	1267535.KB906767_gene844	3.525e-161	521.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria,2JHUM@204432|Acidobacteriia	204432|Acidobacteriia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD1_k127_6491255_3	234267.Acid_1287	7.956e-37	143.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_6491403_2	234267.Acid_5431	8.823e-22	96.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_6491403_0	234267.Acid_0104	3.359e-156	514.0	COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria	57723|Acidobacteria	M	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD1_k127_6491403_1	234267.Acid_5770	1.944e-106	383.0	COG4625@1|root,COG4932@1|root,COG4625@2|Bacteria,COG4932@2|Bacteria,3Y354@57723|Acidobacteria	57723|Acidobacteria	M	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
HFD1_k127_6492950_13	234267.Acid_0745	2.173e-11	66.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD1_k127_6492950_0	234267.Acid_0746	0.0	1422.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria	57723|Acidobacteria	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD1_k127_6492950_1	234267.Acid_0748	0.0	1247.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria	57723|Acidobacteria	M	Surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HFD1_k127_6492950_4	234267.Acid_0749	1.563e-158	505.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria	57723|Acidobacteria	H	MoeZ MoeB domain	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD1_k127_6492950_6	234267.Acid_6265	4.316e-96	341.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_6492950_10	401053.AciPR4_2718	1.837e-21	110.0	COG3710@1|root,COG3710@2|Bacteria,3Y7KB@57723|Acidobacteria,2JMW2@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_6492950_7	1267533.KB906736_gene1045	7.38e-53	194.0	2E3HM@1|root,32YG7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6492950_3	1267533.KB906740_gene289	7.512e-195	620.0	COG1858@1|root,COG1858@2|Bacteria,3Y6XX@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6492950_5	234267.Acid_6791	1.057e-124	409.0	COG4974@1|root,COG4974@2|Bacteria,3Y73V@57723|Acidobacteria	57723|Acidobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD1_k127_6492950_11	1267535.KB906767_gene2023	6.23e-21	93.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD1_k127_6492950_14	1267535.KB906767_gene2023	8.835e-05	48.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD1_k127_6492950_9	234267.Acid_3223	3.504e-31	134.0	28ZVZ@1|root,2ZMKG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6492950_2	234267.Acid_7636	3.887e-207	678.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD1_k127_6492950_8	234267.Acid_7677	4.856e-38	145.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_6496486_2	234267.Acid_3369	5.338e-144	474.0	2E93F@1|root,333CD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6496486_0	234267.Acid_5331	7.551e-306	948.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD1_k127_6496486_4	234267.Acid_5946	1.569e-102	339.0	COG0454@1|root,COG0456@2|Bacteria,3Y8IK@57723|Acidobacteria	57723|Acidobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_6496486_3	234267.Acid_1709	8.757e-110	362.0	28HGI@1|root,2Z7SC@2|Bacteria,3Y3VE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6496486_6	234267.Acid_1708	3.866e-33	149.0	COG5207@1|root,COG5207@2|Bacteria,3Y5QE@57723|Acidobacteria	57723|Acidobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HFD1_k127_6496486_1	1120985.AUMI01000016_gene1829	1.627e-279	888.0	COG0251@1|root,COG0251@2|Bacteria,1VT5Z@1239|Firmicutes	1239|Firmicutes	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6496486_5	1123276.KB893264_gene4598	5.432e-46	178.0	COG2133@1|root,COG3386@1|root,COG4386@1|root,COG2133@2|Bacteria,COG3386@2|Bacteria,COG4386@2|Bacteria,4PNUT@976|Bacteroidetes,47YJ9@768503|Cytophagia	976|Bacteroidetes	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_6503046_3	1168289.AJKI01000024_gene1485	5.006e-113	379.0	COG0591@1|root,COG0591@2|Bacteria,4NH7H@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K14387	ko04725,ko05231,map04725,map05231	-	-	-	ko00000,ko00001,ko02000	2.A.21,2.A.21.8	-	-	HD_4,SSF
HFD1_k127_6503046_8	1054860.KB913030_gene3351	1.785e-11	74.0	COG0454@1|root,COG0456@2|Bacteria,2IFMH@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_6503046_5	886293.Sinac_5705	6.541e-65	233.0	COG1183@1|root,COG1183@2|Bacteria,2IZDE@203682|Planctomycetes	203682|Planctomycetes	I	phosphatidylcholine synthase activity	-	-	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	-
HFD1_k127_6503046_1	234267.Acid_1134	5.029e-223	697.0	COG4225@1|root,COG4225@2|Bacteria,3Y6Y6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
HFD1_k127_6503046_7	234267.Acid_1042	1.977e-50	180.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
HFD1_k127_6503046_2	234267.Acid_1043	6.817e-162	527.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD1_k127_6503046_0	234267.Acid_1055	3.274e-264	818.0	COG0277@1|root,COG0277@2|Bacteria,3Y68N@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD1_k127_6503046_4	234267.Acid_1059	1.07e-70	242.0	COG0691@1|root,COG0691@2|Bacteria,3Y4CC@57723|Acidobacteria	57723|Acidobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HFD1_k127_6503046_6	234267.Acid_1060	3.582e-57	202.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N,TPR_8
HFD1_k127_6538341_4	234267.Acid_5751	1.914e-85	286.0	2DB8V@1|root,2Z7SX@2|Bacteria	2|Bacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD1_k127_6538341_14	391623.TERMP_01575	3.612e-05	57.0	COG3291@1|root,arCOG02499@1|root,arCOG02501@1|root,arCOG02545@1|root,arCOG03439@1|root,arCOG03610@1|root,arCOG02499@2157|Archaea,arCOG02501@2157|Archaea,arCOG02545@2157|Archaea,arCOG03439@2157|Archaea,arCOG03610@2157|Archaea,arCOG05189@2157|Archaea,2XXWR@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
HFD1_k127_6538341_12	1183438.GKIL_3047	3.701e-17	96.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM26,Cytochrome_CBB3,GSDH,Laminin_G_3,PA14,PSCyt3,PSD2,PSD3,PSD4,PSD5,Ricin_B_lectin,TadE
HFD1_k127_6538341_1	234267.Acid_2445	6.993e-218	688.0	COG2234@1|root,COG2234@2|Bacteria,3Y3KE@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_6538341_8	234267.Acid_2441	3.409e-48	181.0	COG2020@1|root,COG2020@2|Bacteria,3Y8EC@57723|Acidobacteria	57723|Acidobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD1_k127_6538341_11	1267533.KB906735_gene5001	5.586e-19	92.0	2FJ4P@1|root,34AUY@2|Bacteria,3Y8PT@57723|Acidobacteria,2JNJ3@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6538341_10	204669.Acid345_1675	1.087e-32	130.0	COG1225@1|root,COG1225@2|Bacteria,3Y8D4@57723|Acidobacteria,2JNH4@204432|Acidobacteriia	204432|Acidobacteriia	O	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
HFD1_k127_6538341_6	1121920.AUAU01000011_gene206	8.08e-57	222.0	COG3852@1|root,COG3852@2|Bacteria,3Y993@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HFD1_k127_6538341_2	234267.Acid_2440	1.692e-190	597.0	COG0604@1|root,COG0604@2|Bacteria,3Y3PP@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_6538341_3	234267.Acid_6441	5.609e-96	338.0	2DEFD@1|root,2ZMSU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6538341_9	234267.Acid_0549	5.623e-42	173.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_6538341_13	247490.KSU1_B0191	6.976e-16	91.0	COG1622@1|root,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HFD1_k127_6538341_0	234267.Acid_5975	0.0	1131.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	2|Bacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	ptpA_1	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD1_k127_6538341_7	357808.RoseRS_0838	1.912e-49	190.0	2DS4G@1|root,32RFP@2|Bacteria,2GB48@200795|Chloroflexi,3770D@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6538341_5	1379270.AUXF01000005_gene535	4.16e-73	261.0	COG1680@1|root,COG1680@2|Bacteria,1ZUKU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_6551741_1	861299.J421_4129	4.342e-176	562.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
HFD1_k127_6551741_0	861299.J421_4127	1.431e-189	621.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	3.2.1.1,3.2.1.41	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	-	R02108,R02111,R02112,R11262	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM26,CBM_20,CBM_25,CBM_48,PUD
HFD1_k127_6555770_1	234267.Acid_6881	1.157e-149	488.0	COG1361@1|root,COG3534@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3534@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	2|Bacteria	M	PKD domain containing protein	-	-	3.4.21.50	ko:K01337,ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Autotransporter,DUF4347,Glyco_hydro_43,He_PIG,P_proprotein,Peptidase_S8,TIG
HFD1_k127_6555770_3	234267.Acid_5410	1.033e-112	396.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
HFD1_k127_6555770_2	880074.BARVI_03030	1.022e-148	502.0	COG1874@1|root,COG1874@2|Bacteria,4PNM8@976|Bacteroidetes,2G105@200643|Bacteroidia,22YWU@171551|Porphyromonadaceae	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6555770_5	234267.Acid_2706	7.739e-101	347.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD1_k127_6555770_0	234267.Acid_0005	1.718e-213	691.0	COG2234@1|root,COG2234@2|Bacteria,3Y3R5@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_6555770_4	743719.PaelaDRAFT_3335	4.753e-110	365.0	COG2130@1|root,COG2130@2|Bacteria,1TQUE@1239|Firmicutes,4HCHY@91061|Bacilli,26QH0@186822|Paenibacillaceae	91061|Bacilli	S	N-terminal domain of oxidoreductase	yfmJ	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HFD1_k127_6555770_8	543632.JOJL01000042_gene4474	1.891e-21	99.0	COG4191@1|root,COG4191@2|Bacteria,2GZ7K@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Peripla_BP_3,Response_reg
HFD1_k127_6555770_7	234267.Acid_2868	5.774e-30	119.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD1_k127_6578400_0	234267.Acid_1009	6.543e-208	653.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria	57723|Acidobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HFD1_k127_6578400_3	234267.Acid_1010	2.486e-11	66.0	COG1826@1|root,COG1826@2|Bacteria,3Y5V7@57723|Acidobacteria	57723|Acidobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD1_k127_6578400_2	234267.Acid_1011	1.16e-41	154.0	COG0776@1|root,COG0776@2|Bacteria,3Y5E1@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_6578400_1	234267.Acid_1012	5.553e-58	209.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD1_k127_6593662_6	234267.Acid_3439	6.2e-56	195.0	COG4948@1|root,COG4948@2|Bacteria,3Y624@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_6593662_2	234267.Acid_4084	1.24e-157	502.0	COG2421@1|root,COG2421@2|Bacteria,3Y40F@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Acetamidase Formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HFD1_k127_6593662_7	234267.Acid_3517	5.572e-54	196.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD1_k127_6593662_4	1095769.CAHF01000022_gene253	1.364e-119	408.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD1_k127_6593662_0	234267.Acid_2189	0.0	1259.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2ZI@57723|Acidobacteria	57723|Acidobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HFD1_k127_6593662_5	234267.Acid_2188	1.412e-97	327.0	COG2197@1|root,COG2197@2|Bacteria,3Y4DR@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_6593662_8	234267.Acid_6828	2.25e-28	119.0	COG0745@1|root,COG0745@2|Bacteria	234267.Acid_6828|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6593662_3	234267.Acid_3836	1.998e-127	416.0	COG1215@1|root,COG1215@2|Bacteria,3Y3J4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD1_k127_6593662_1	1267535.KB906767_gene223	7.26e-313	993.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y6I3@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6610789_1	234267.Acid_5473	5.034e-73	251.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_6610789_3	1267533.KB906734_gene4050	2.275e-29	121.0	COG5552@1|root,COG5552@2|Bacteria,3Y864@57723|Acidobacteria,2JN8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HFD1_k127_6610789_0	234267.Acid_4388	7.682e-113	366.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD1_k127_6610789_2	234267.Acid_4387	1.877e-39	149.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD1_k127_6611915_7	1299327.I546_6183	4.838e-33	129.0	COG1848@1|root,COG1848@2|Bacteria,2IJ89@201174|Actinobacteria,239HU@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HFD1_k127_6611915_10	1144310.PMI07_000680	9.947e-18	88.0	COG2337@1|root,COG2337@2|Bacteria,1RI5U@1224|Proteobacteria,2UV6D@28211|Alphaproteobacteria,4BHSU@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K18841	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD1_k127_6611915_11	1121948.AUAC01000002_gene1108	4.946e-14	73.0	COG2337@1|root,COG2337@2|Bacteria,1MZJ8@1224|Proteobacteria,2U9QV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD1_k127_6611915_9	627192.SLG_24190	2.328e-22	98.0	COG2336@1|root,COG2336@2|Bacteria,1N9Z6@1224|Proteobacteria,2UGQK@28211|Alphaproteobacteria,2KBCM@204457|Sphingomonadales	204457|Sphingomonadales	T	SpoVT / AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	-
HFD1_k127_6611915_0	234267.Acid_7040	0.0	1045.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria	57723|Acidobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD1_k127_6611915_2	886293.Sinac_4910	1.403e-218	694.0	COG1082@1|root,COG1082@2|Bacteria,2J24A@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyl-hydrolase 97 N-terminal	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
HFD1_k127_6611915_5	234267.Acid_3613	3.917e-50	185.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD1_k127_6611915_1	234267.Acid_7444	1.183e-288	894.0	COG1022@1|root,COG1022@2|Bacteria,3Y2KU@57723|Acidobacteria	57723|Acidobacteria	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD1_k127_6611915_3	234267.Acid_7445	1.935e-74	259.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD1_k127_6611915_4	234267.Acid_7446	3.874e-55	199.0	2C8FH@1|root,33NBI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6611915_8	234267.Acid_7447	3.246e-29	119.0	COG1334@1|root,COG1334@2|Bacteria	2|Bacteria	N	flagellar protein FlaG	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
HFD1_k127_6611915_6	234267.Acid_7448	1.937e-38	155.0	COG1516@1|root,COG1516@2|Bacteria,3Y5UU@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar protein FliS	-	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
HFD1_k127_6611915_12	234267.Acid_5308	5.894e-11	65.0	COG1943@1|root,COG1943@2|Bacteria,3Y84T@57723|Acidobacteria	57723|Acidobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD1_k127_6637608_0	886293.Sinac_1529	6.539e-101	340.0	COG0673@1|root,COG0673@2|Bacteria,2IXAZ@203682|Planctomycetes	203682|Planctomycetes	S	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_6637608_1	886293.Sinac_1528	6.763e-30	134.0	COG2259@1|root,COG2259@2|Bacteria,2J13W@203682|Planctomycetes	203682|Planctomycetes	S	Doxx family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD1_k127_6637608_2	886293.Sinac_1527	6.915e-13	71.0	COG1477@1|root,COG1477@2|Bacteria,2IYYX@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD1_k127_6657851_1	234267.Acid_1382	7.781e-77	268.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6657851_2	234267.Acid_2237	4.408e-47	175.0	COG0279@1|root,COG0279@2|Bacteria,3Y7D7@57723|Acidobacteria	57723|Acidobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD1_k127_6657851_0	234267.Acid_6796	9.578e-157	513.0	COG2885@1|root,COG2885@2|Bacteria,3Y310@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD1_k127_6657851_3	639030.JHVA01000001_gene2859	7.691e-36	149.0	COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria,2JJS0@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_665947_2	234267.Acid_3441	5.214e-76	263.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Esterase
HFD1_k127_665947_0	234267.Acid_2705	0.0	1315.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_665947_1	1267535.KB906767_gene1185	2.72e-109	359.0	COG1082@1|root,COG1082@2|Bacteria,3Y7BC@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_6671224_22	234267.Acid_2848	2.469e-32	126.0	COG1044@1|root,COG1044@2|Bacteria,3Y6ZT@57723|Acidobacteria	57723|Acidobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD1_k127_6671224_16	234267.Acid_2847	4.897e-84	286.0	2E19M@1|root,2ZCDB@2|Bacteria,3Y4DH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6671224_10	234267.Acid_2815	1.152e-122	408.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD1_k127_6671224_8	234267.Acid_4998	1.183e-127	425.0	COG2017@1|root,COG2017@2|Bacteria,3Y7G9@57723|Acidobacteria	57723|Acidobacteria	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
HFD1_k127_6671224_18	1379698.RBG1_1C00001G0328	1.831e-58	206.0	2C7E0@1|root,330TX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6671224_25	1183438.GKIL_2277	3.357e-11	74.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_4
HFD1_k127_6671224_15	234267.Acid_5339	2.063e-93	313.0	COG1131@1|root,COG1131@2|Bacteria,3Y3U0@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_6671224_14	234267.Acid_5340	4.052e-103	355.0	COG0577@1|root,COG0577@2|Bacteria,3Y4J3@57723|Acidobacteria	57723|Acidobacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6671224_0	234267.Acid_5429	0.0	1527.0	COG0841@1|root,COG0841@2|Bacteria,3Y63J@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD1_k127_6671224_3	497964.CfE428DRAFT_4340	9.166e-179	575.0	COG3119@1|root,COG3119@2|Bacteria,46UNA@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD1_k127_6671224_20	234267.Acid_1190	2.162e-41	161.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD1_k127_6671224_11	234267.Acid_3830	1.973e-119	392.0	COG0395@1|root,COG0395@2|Bacteria,3Y7HR@57723|Acidobacteria	57723|Acidobacteria	G	Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HFD1_k127_6671224_27	1382356.JQMP01000004_gene180	1.129e-05	53.0	COG4961@1|root,COG4961@2|Bacteria,2GBBH@200795|Chloroflexi,27YNU@189775|Thermomicrobia	189775|Thermomicrobia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD1_k127_6671224_23	1219045.BV98_003779	2.044e-28	130.0	COG4961@1|root,COG4961@2|Bacteria,1QV5Z@1224|Proteobacteria,2TWAQ@28211|Alphaproteobacteria,2K52P@204457|Sphingomonadales	204457|Sphingomonadales	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD1_k127_6671224_24	234267.Acid_2743	2.217e-21	98.0	2CHJJ@1|root,2ZDZ3@2|Bacteria,3Y94T@57723|Acidobacteria	234267.Acid_2743|-	S	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6671224_2	234267.Acid_6538	2.505e-213	671.0	COG1012@1|root,COG1012@2|Bacteria,3Y2Q5@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_6671224_1	234267.Acid_3590	2.822e-299	956.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF11,DUF4384,Flg_new,TonB_dep_Rec
HFD1_k127_6671224_21	234267.Acid_7413	1.727e-40	156.0	2E5J5@1|root,330AF@2|Bacteria,3Y5HZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HFD1_k127_6671224_6	234267.Acid_2453	1.651e-133	434.0	COG3959@1|root,COG3959@2|Bacteria,3Y4PX@57723|Acidobacteria	57723|Acidobacteria	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD1_k127_6671224_5	234267.Acid_2452	1.344e-150	495.0	COG3958@1|root,COG3958@2|Bacteria,3Y7P5@57723|Acidobacteria	57723|Acidobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD1_k127_6671224_9	234267.Acid_2451	2.27e-127	416.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K11617	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8,Sensor
HFD1_k127_6671224_7	234267.Acid_2450	4.691e-131	420.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HFD1_k127_6671224_12	234267.Acid_2449	1.553e-116	382.0	COG2159@1|root,COG2159@2|Bacteria,3Y6P0@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_6671224_4	234267.Acid_3659	3.007e-166	528.0	2DBK2@1|root,2Z9Q1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6671224_13	234267.Acid_2656	2.845e-114	381.0	COG0457@1|root,COG0457@2|Bacteria,3Y77J@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_11,TPR_16
HFD1_k127_6672029_4	234267.Acid_3680	9.171e-89	305.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_6672029_3	489825.LYNGBM3L_21120	1.694e-89	310.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1H7YK@1150|Oscillatoriales	2|Bacteria	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K00713,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_6672029_5	1449355.JQNR01000005_gene5019	2.223e-34	142.0	28PFR@1|root,2ZC6V@2|Bacteria,2GMR6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_4
HFD1_k127_6672029_0	234267.Acid_1518	2.268e-190	600.0	COG0673@1|root,COG0673@2|Bacteria,3Y74B@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_6672029_2	234267.Acid_1519	1.421e-140	454.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
HFD1_k127_6672029_9	234267.Acid_7217	8.636e-16	81.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6672029_7	234267.Acid_0571	6.552e-32	128.0	COG0346@1|root,COG0346@2|Bacteria,3Y85T@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_6672029_8	234267.Acid_0572	4.975e-21	95.0	2EAHU@1|root,334M0@2|Bacteria,3Y5JU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6672029_1	234267.Acid_1733	5.764e-159	527.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1733|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6672029_6	234267.Acid_2812	3.736e-32	126.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria	57723|Acidobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD1_k127_6673885_1	234267.Acid_7714	6.193e-87	289.0	COG1159@1|root,COG1159@2|Bacteria,3Y2GE@57723|Acidobacteria	57723|Acidobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HFD1_k127_6673885_4	234267.Acid_7715	1.176e-20	94.0	COG2823@1|root,COG2823@2|Bacteria,3Y8T3@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HFD1_k127_6673885_0	234267.Acid_7716	2.903e-110	368.0	COG3386@1|root,COG3386@2|Bacteria,3Y5XH@57723|Acidobacteria	57723|Acidobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD1_k127_6673885_2	234267.Acid_7717	2.966e-61	228.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria	57723|Acidobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD1_k127_6673885_3	234267.Acid_7718	6.231e-48	175.0	COG1193@1|root,COG1193@2|Bacteria,3Y2Z2@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HFD1_k127_6674562_1	1340493.JNIF01000003_gene3864	4.539e-177	560.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_6674562_4	794903.OPIT5_18890	2.641e-67	246.0	COG0823@1|root,COG0823@2|Bacteria,46SJJ@74201|Verrucomicrobia,3K8Y0@414999|Opitutae	414999|Opitutae	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6674562_5	1254432.SCE1572_23875	2.169e-29	130.0	COG0454@1|root,COG0456@2|Bacteria,1NCW1@1224|Proteobacteria,42XYS@68525|delta/epsilon subdivisions,2WT5Q@28221|Deltaproteobacteria,2Z06J@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
HFD1_k127_6674562_7	283699.D172_4039	5.475e-05	52.0	COG3772@1|root,COG3772@2|Bacteria,1N0ZQ@1224|Proteobacteria,1S9AE@1236|Gammaproteobacteria,2Q38I@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Phage lysozyme	-	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	Phage_lysozyme
HFD1_k127_6674562_0	234267.Acid_3901	0.0	1080.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Abhydrolase_3,Glyco_hyd_65N_2
HFD1_k127_6674562_6	401053.AciPR4_3197	1.407e-06	53.0	COG1044@1|root,COG1044@2|Bacteria	2|Bacteria	M	lipid A biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6674562_2	234267.Acid_3900	7.497e-119	383.0	COG0740@1|root,COG0740@2|Bacteria,3Y2SY@57723|Acidobacteria	57723|Acidobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD1_k127_6674562_3	234267.Acid_3899	8.196e-76	255.0	COG1959@1|root,COG1959@2|Bacteria,3Y8ZE@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD1_k127_6674921_2	234267.Acid_0378	3.655e-41	166.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HFD1_k127_6674921_1	204669.Acid345_0496	3.57e-77	266.0	COG3568@1|root,COG3568@2|Bacteria,3Y4HM@57723|Acidobacteria,2JKST@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD1_k127_6674921_0	234267.Acid_0380	8.308e-175	557.0	COG1502@1|root,COG1502@2|Bacteria,3Y2GD@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD1_k127_6674921_3	452637.Oter_2274	1.85e-16	94.0	28N78@1|root,2ZBBY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4932
HFD1_k127_6686671_5	1094466.KQS_00360	0.0002472	53.0	COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia,2NU4E@237|Flavobacterium	976|Bacteroidetes	T	BatE protein	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
HFD1_k127_6686671_1	1267533.KB906741_gene424	2.117e-250	791.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria,2JIN0@204432|Acidobacteriia	204432|Acidobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD1_k127_6686671_2	1267533.KB906741_gene420	2.011e-40	156.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria,2JN2R@204432|Acidobacteriia	204432|Acidobacteriia	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD1_k127_6686671_3	1304885.AUEY01000050_gene1196	1.495e-19	93.0	COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2MKZY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD1_k127_6686671_4	1123376.AUIU01000016_gene307	2.493e-17	87.0	COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD1_k127_6686671_0	1267534.KB906754_gene3061	8.038e-276	870.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria,2JHMJ@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD1_k127_6694373_3	1267534.KB906758_gene2377	2.152e-132	428.0	COG2133@1|root,COG2133@2|Bacteria,3Y3FI@57723|Acidobacteria,2JIAK@204432|Acidobacteriia	204432|Acidobacteriia	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_6694373_16	1121015.N789_05925	2.931e-27	128.0	COG4200@1|root,COG4200@2|Bacteria,1MYGC@1224|Proteobacteria,1SXTK@1236|Gammaproteobacteria,1X6R1@135614|Xanthomonadales	135614|Xanthomonadales	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_4
HFD1_k127_6694373_10	1384054.N790_09405	1.215e-73	260.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RY6M@1236|Gammaproteobacteria,1X6RZ@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K19340	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC_tran
HFD1_k127_6694373_19	419947.MRA_2623A	1.593e-12	74.0	COG2002@1|root,COG2002@2|Bacteria,2HANT@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6694373_18	272134.KB731324_gene1612	2.242e-17	89.0	COG1848@1|root,COG1848@2|Bacteria,1G6WR@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_6694373_11	1267535.KB906767_gene928	5.763e-63	238.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
HFD1_k127_6694373_8	234267.Acid_4359	3.985e-85	288.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD1_k127_6694373_13	234267.Acid_4039	1.846e-57	206.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	-	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD1_k127_6694373_5	234267.Acid_4038	8.78e-115	374.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD1_k127_6694373_7	234267.Acid_4037	3.588e-86	294.0	COG1502@1|root,COG1502@2|Bacteria,3Y5UA@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD1_k127_6694373_17	215803.DB30_5211	3.81e-23	110.0	COG1285@1|root,COG1285@2|Bacteria,1PD3I@1224|Proteobacteria,439E8@68525|delta/epsilon subdivisions,2X4PA@28221|Deltaproteobacteria,2YZCD@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HFD1_k127_6694373_14	671143.DAMO_1104	4.048e-42	173.0	COG3746@1|root,COG3746@2|Bacteria,2NRQ1@2323|unclassified Bacteria	2|Bacteria	P	phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
HFD1_k127_6694373_6	234267.Acid_4036	7.272e-106	368.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH,Lectin_C
HFD1_k127_6694373_2	234267.Acid_4029	1.072e-178	580.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	ppe2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos,Pur_ac_phosph_N,TAT_signal
HFD1_k127_6694373_0	234267.Acid_3484	0.0	1089.0	COG0457@1|root,COG0457@2|Bacteria,3Y2Q7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD1_k127_6694373_1	1267535.KB906767_gene8	3.554e-235	739.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD1_k127_6694373_4	1340493.JNIF01000004_gene855	3.479e-117	397.0	COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_6694373_9	1340493.JNIF01000004_gene856	3.666e-82	289.0	COG0745@1|root,COG0745@2|Bacteria	1340493.JNIF01000004_gene856|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6694373_15	234267.Acid_2779	1.154e-29	134.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg
HFD1_k127_6696003_1	234267.Acid_1486	6.09e-161	510.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HFD1_k127_6696003_4	234267.Acid_1487	2.747e-45	170.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
HFD1_k127_6696003_3	1340493.JNIF01000003_gene1750	3.033e-144	466.0	COG0183@1|root,COG0183@2|Bacteria,3Y7RP@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HFD1_k127_6696003_0	234267.Acid_0368	7.054e-211	661.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD1_k127_6696003_2	234267.Acid_6488	1.894e-153	509.0	COG1629@1|root,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_6723538_0	1278309.KB907099_gene2913	2.831e-315	1022.0	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6739217_1	234267.Acid_4427	4.491e-78	262.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria	57723|Acidobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD1_k127_6739217_2	390989.JOEG01000001_gene5344	7.845e-63	226.0	COG2227@1|root,COG2227@2|Bacteria,2I4VV@201174|Actinobacteria,4DMR7@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD1_k127_6739217_0	1340493.JNIF01000003_gene1928	1.94e-142	496.0	COG1629@1|root,COG1629@2|Bacteria,3Y2FQ@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_6739217_3	1382359.JIAL01000001_gene178	1.23e-33	135.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD1_k127_6741125_4	234267.Acid_3333	7.288e-29	116.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	OmpA,PD40,PI-PLC-X,Pectate_lyase22,TIR_2
HFD1_k127_6741125_2	234267.Acid_3088	5.298e-137	440.0	COG3291@1|root,COG3291@2|Bacteria,3Y76G@57723|Acidobacteria	2|Bacteria	S	Domain of Unknown Function (DUF1080)	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	DUF1080,LRR_5,PKD
HFD1_k127_6741125_3	234267.Acid_3071	3.733e-117	383.0	COG2010@1|root,COG2010@2|Bacteria,3Y6FM@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD1_k127_6741125_0	234267.Acid_3070	1.071e-317	976.0	COG4993@1|root,COG4993@2|Bacteria,3Y65P@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_6741125_1	234267.Acid_5413	5.206e-252	814.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6AS@57723|Acidobacteria	57723|Acidobacteria	CG	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_6745783_9	1248760.ANFZ01000006_gene2506	2.312e-75	262.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria,2K0EC@204457|Sphingomonadales	204457|Sphingomonadales	P	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sulfate_transp
HFD1_k127_6745783_0	234267.Acid_1240	0.0	1718.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C,Plug,TonB_dep_Rec
HFD1_k127_6745783_1	234267.Acid_1241	4.899e-235	749.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	MA20_44000	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase
HFD1_k127_6745783_15	387092.NIS_1496	2.927e-12	68.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42VNG@68525|delta/epsilon subdivisions,2YQ9F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD1_k127_6745783_7	234267.Acid_1270	2.218e-86	296.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD1_k127_6745783_8	234267.Acid_4621	1.008e-85	299.0	29ZE1@1|root,30MD7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6745783_4	234267.Acid_1433	2.297e-209	653.0	COG2021@1|root,COG2021@2|Bacteria,3Y4EW@57723|Acidobacteria	57723|Acidobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_6745783_6	234267.Acid_1432	5.357e-88	309.0	COG0500@1|root,COG2226@2|Bacteria,3Y7N3@57723|Acidobacteria	57723|Acidobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
HFD1_k127_6745783_5	234267.Acid_1197	7.172e-138	449.0	COG2890@1|root,COG4797@1|root,COG2890@2|Bacteria,COG4797@2|Bacteria,3Y65M@57723|Acidobacteria	57723|Acidobacteria	J	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg
HFD1_k127_6745783_11	234267.Acid_1195	2.464e-50	191.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria	57723|Acidobacteria	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HFD1_k127_6745783_10	234267.Acid_1194	6.451e-58	204.0	COG4911@1|root,COG4911@2|Bacteria,3Y4VB@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HFD1_k127_6745783_2	234267.Acid_1193	1.26e-230	718.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria	57723|Acidobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HFD1_k127_6745783_16	1121285.AUFK01000011_gene356	0.0006272	49.0	COG4129@1|root,COG4129@2|Bacteria,4NXBI@976|Bacteroidetes,1I5XD@117743|Flavobacteriia	976|Bacteroidetes	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
HFD1_k127_6745783_3	234267.Acid_5520	7.925e-228	724.0	COG0578@1|root,COG0578@2|Bacteria,3Y2YF@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HFD1_k127_6745783_12	1121472.AQWN01000011_gene1205	4.278e-31	139.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,264HD@186807|Peptococcaceae	186801|Clostridia	G	Periplasmic binding protein-like domain	alsB	-	-	ko:K10439,ko:K10549	ko02010,ko02030,map02010,map02030	M00212,M00217	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.6	-	-	Peripla_BP_4
HFD1_k127_6755678_17	234267.Acid_7372	3.654e-46	171.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HFD1_k127_6755678_22	557599.MKAN_00640	2.78e-15	81.0	COG5579@1|root,COG5579@2|Bacteria,2IM9J@201174|Actinobacteria,239PD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HFD1_k127_6755678_10	234267.Acid_7619	3.573e-131	430.0	COG1484@1|root,COG1484@2|Bacteria,3Y7G6@57723|Acidobacteria	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	istB3	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21,IstB_IS21_ATP
HFD1_k127_6755678_4	234267.Acid_7618	1.971e-236	742.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
HFD1_k127_6755678_19	557599.MKAN_00640	1.825e-30	130.0	COG5579@1|root,COG5579@2|Bacteria,2IM9J@201174|Actinobacteria,239PD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HFD1_k127_6755678_5	234267.Acid_7891	1.238e-199	641.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD1_k127_6755678_16	234267.Acid_7821	6.109e-55	196.0	COG1555@1|root,COG1555@2|Bacteria,3Y869@57723|Acidobacteria	57723|Acidobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD1_k127_6755678_7	234267.Acid_7820	1.485e-149	489.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_6755678_13	234267.Acid_7819	6.887e-89	310.0	COG2755@1|root,COG2755@2|Bacteria,3Y4BD@57723|Acidobacteria	57723|Acidobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD1_k127_6755678_3	234267.Acid_7818	1.723e-289	900.0	COG1520@1|root,COG1520@2|Bacteria,3Y6S9@57723|Acidobacteria	57723|Acidobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6755678_0	234267.Acid_3492	0.0	1724.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WQ@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6755678_9	1267535.KB906767_gene3810	2.974e-143	472.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene3810|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6755678_6	1267535.KB906767_gene32	1.136e-179	578.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD1_k127_6755678_12	234267.Acid_3494	3.219e-119	393.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B2@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HFD1_k127_6755678_2	234267.Acid_1227	0.0	1089.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_1227|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6755678_11	1469607.KK073768_gene3472	1.599e-126	412.0	COG0667@1|root,COG0667@2|Bacteria,1G3RI@1117|Cyanobacteria,1HMNR@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_6755678_20	661478.OP10G_1598	2.044e-30	124.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6755678_18	234267.Acid_4266	4.079e-37	154.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_6755678_8	1115632.JAFW01000001_gene1286	3.45e-144	484.0	COG0642@1|root,COG0642@2|Bacteria,2I58H@201174|Actinobacteria	201174|Actinobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
HFD1_k127_6755678_25	316067.Geob_1149	4.239e-06	55.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD
HFD1_k127_6755678_24	234267.Acid_4695	2.911e-07	56.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HFD1_k127_6755678_1	1242864.D187_003102	0.0	1264.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD1_k127_6755678_26	1336208.JADY01000021_gene4018	1.508e-05	51.0	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,2JVJD@204441|Rhodospirillales	204441|Rhodospirillales	KL	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
HFD1_k127_6755678_21	234267.Acid_4696	5.86e-29	120.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K03409,ko:K04749,ko:K07122	ko02010,ko02030,map02010,map02030	M00210	-	-	ko00000,ko00001,ko00002,ko02000,ko02035,ko03021	3.A.1.27.3	-	-	STAS,STAS_2
HFD1_k127_6755678_14	234267.Acid_4697	4.69e-88	292.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD1_k127_6756868_9	234267.Acid_7046	4.069e-48	173.0	2FF7H@1|root,3475G@2|Bacteria,3Y8K8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6756868_6	234267.Acid_4375	5.549e-70	244.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_6756868_7	234267.Acid_5739	2.377e-64	231.0	2DJMQ@1|root,32UDD@2|Bacteria,3Y57W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6756868_8	234267.Acid_5737	1.12e-60	215.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_6756868_11	1433126.BN938_1424	1.489e-22	108.0	COG2520@1|root,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	XK27_03530	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,rRNA_methylase
HFD1_k127_6756868_4	234267.Acid_6711	1.242e-94	313.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
HFD1_k127_6756868_5	234267.Acid_6710	2.458e-76	258.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria	57723|Acidobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD1_k127_6756868_2	1340493.JNIF01000003_gene4499	9.145e-158	525.0	COG1404@1|root,COG1404@2|Bacteria,3Y5WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
HFD1_k127_6756868_0	234267.Acid_6709	4.421e-280	895.0	COG1404@1|root,COG1404@2|Bacteria,3Y5WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
HFD1_k127_6756868_3	234267.Acid_6708	2.28e-136	441.0	COG0294@1|root,COG0294@2|Bacteria,3Y4JJ@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD1_k127_6756868_1	234267.Acid_6744	4.888e-257	814.0	COG1452@1|root,COG1934@1|root,COG1452@2|Bacteria,COG1934@2|Bacteria,3Y388@57723|Acidobacteria	57723|Acidobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
HFD1_k127_6756868_10	234267.Acid_6743	7.8e-46	166.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD1_k127_6761316_12	234267.Acid_0467	3.907e-68	246.0	COG0463@1|root,COG1807@1|root,COG2246@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria,COG2246@2|Bacteria,3Y4P3@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HFD1_k127_6761316_9	234267.Acid_6451	6.67e-83	282.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	-	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD1_k127_6761316_4	234267.Acid_3807	7.026e-211	662.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_6761316_3	234267.Acid_3806	2.391e-211	663.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_6761316_23	1123248.KB893314_gene3535	4.842e-09	66.0	COG2350@1|root,COG2350@2|Bacteria,4NNMS@976|Bacteroidetes,1ITUD@117747|Sphingobacteriia	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_6761316_24	655815.ZPR_0286	1.031e-06	59.0	COG2350@1|root,COG2350@2|Bacteria,4NNMS@976|Bacteroidetes,1I22W@117743|Flavobacteriia	976|Bacteroidetes	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_6761316_7	234267.Acid_4938	4.362e-118	383.0	COG2043@1|root,COG2043@2|Bacteria,3Y6QC@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HFD1_k127_6761316_5	234267.Acid_2804	1.049e-162	520.0	COG4299@1|root,COG4299@2|Bacteria,3Y2J9@57723|Acidobacteria	57723|Acidobacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
HFD1_k127_6761316_22	861299.J421_1452	1.167e-10	68.0	297M3@1|root,2ZUU3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6761316_14	1267535.KB906767_gene5023	1.542e-58	209.0	COG3644@1|root,COG3644@2|Bacteria	2|Bacteria	M	Uncharacterized protein conserved in bacteria (DUF2239)	-	-	-	ko:K09965	-	-	-	-	ko00000	-	-	-	DUF2239
HFD1_k127_6761316_18	234267.Acid_5657	1.819e-42	166.0	COG5349@1|root,COG5349@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF983)	MA20_36345	-	-	-	-	-	-	-	-	-	-	-	DUF983
HFD1_k127_6761316_1	234267.Acid_2975	1.314e-267	861.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_6761316_16	688245.CtCNB1_2775	2.654e-43	160.0	COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,2VTRD@28216|Betaproteobacteria,4AENN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HFD1_k127_6761316_20	1340493.JNIF01000003_gene2598	8.547e-24	110.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_6761316_13	926566.Terro_1495	1.551e-62	238.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
HFD1_k127_6761316_15	926566.Terro_1494	2.937e-58	231.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cecB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_D23
HFD1_k127_6761316_0	1340493.JNIF01000003_gene4834	0.0	1086.0	COG3696@1|root,COG3696@2|Bacteria,3Y6AY@57723|Acidobacteria	57723|Acidobacteria	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
HFD1_k127_6761316_11	379066.GAU_3842	1.55e-71	250.0	COG0745@1|root,COG0745@2|Bacteria,1ZTNE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_6761316_10	234267.Acid_5478	1.83e-77	278.0	COG0642@1|root,COG2205@2|Bacteria,3Y8HM@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_6761316_6	1089547.KB913013_gene998	9.752e-149	482.0	COG1520@1|root,COG1520@2|Bacteria,4NK4X@976|Bacteroidetes,47KWI@768503|Cytophagia	976|Bacteroidetes	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6761316_17	1267534.KB906758_gene2512	5.774e-43	163.0	COG1595@1|root,COG1595@2|Bacteria,3Y84Y@57723|Acidobacteria,2JN76@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_6761316_21	1267535.KB906767_gene4878	6.017e-20	101.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02453,ko:K02666	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	CarbopepD_reg_2,Secretin,Secretin_N
HFD1_k127_6761316_2	234267.Acid_2606	2.257e-265	827.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	celD	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calycin_like,CelD_N,DUF1080,Glyco_hydro_9,PCMD
HFD1_k127_6761316_19	1340493.JNIF01000003_gene2224	6.297e-41	153.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_6761316_8	234267.Acid_1045	4.386e-100	355.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6768437_8	234267.Acid_7029	3.612e-93	311.0	COG1295@1|root,COG1295@2|Bacteria,3Y3AJ@57723|Acidobacteria	57723|Acidobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD1_k127_6768437_6	234267.Acid_7028	9.342e-201	636.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	gatA3	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD1_k127_6768437_0	234267.Acid_7026	0.0	1086.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6768437_9	234267.Acid_6539	2.376e-73	254.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD1_k127_6768437_1	234267.Acid_7115	0.0	1052.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,3Y3YD@57723|Acidobacteria	57723|Acidobacteria	E	homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
HFD1_k127_6768437_7	234267.Acid_7116	3.61e-115	373.0	COG0009@1|root,COG0009@2|Bacteria,3Y43Z@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
HFD1_k127_6768437_12	1267535.KB906767_gene5477	2.341e-53	201.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6768437_11	234267.Acid_0414	9.922e-66	227.0	COG0756@1|root,COG0756@2|Bacteria,3Y58S@57723|Acidobacteria	57723|Acidobacteria	F	dUTPase	-	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD1_k127_6768437_5	234267.Acid_0415	1.135e-226	711.0	COG1351@1|root,COG1351@2|Bacteria,3Y3AY@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
HFD1_k127_6768437_17	1293047.CBMA010000008_gene342	2.326e-12	79.0	COG0382@1|root,arCOG00481@2157|Archaea,2XVK8@28890|Euryarchaeota,23S8B@183963|Halobacteria	183963|Halobacteria	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	ubiA3	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD1_k127_6768437_3	234267.Acid_0426	9.979e-254	786.0	COG3829@1|root,COG3829@2|Bacteria,3Y988@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
HFD1_k127_6768437_2	234267.Acid_0431	5.258e-276	862.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
HFD1_k127_6768437_4	234267.Acid_0432	4.801e-247	770.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD1_k127_6768437_10	880073.Calab_1598	3.899e-69	242.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HFD1_k127_6769184_2	234267.Acid_5485	3.089e-15	84.0	COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_6769184_0	234267.Acid_5484	1.185e-130	428.0	COG0845@1|root,COG0845@2|Bacteria,3Y3C9@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD1_k127_6769184_1	234267.Acid_5483	5.233e-28	115.0	COG1538@1|root,COG1538@2|Bacteria,3Y3PX@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_67710_2	234267.Acid_0024	5.787e-156	527.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_67710_3	497964.CfE428DRAFT_6245	1.037e-35	158.0	COG0515@1|root,COG0515@2|Bacteria,46U28@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD1_k127_67710_0	861299.J421_2157	1.146e-187	629.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
HFD1_k127_67710_4	1120925.F941_00134	4.295e-16	94.0	COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,1T1QK@1236|Gammaproteobacteria,3NJ16@468|Moraxellaceae	1236|Gammaproteobacteria	P	Catalase	-	-	-	-	-	-	-	-	-	-	-	-	Catalase
HFD1_k127_67710_1	1121015.N789_10540	2.673e-160	545.0	COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6783670_0	234267.Acid_3931	7.85e-301	943.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_6783670_1	1267534.KB906756_gene237	9.849e-164	549.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria,2JIMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HFD1_k127_6786279_0	234267.Acid_2665	1.953e-288	923.0	COG2067@1|root,COG2067@2|Bacteria,3Y41G@57723|Acidobacteria	57723|Acidobacteria	I	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_6786279_1	886293.Sinac_5627	1.546e-123	413.0	COG2421@1|root,COG2421@2|Bacteria,2J06T@203682|Planctomycetes	203682|Planctomycetes	C	acetamidase formamidase	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
HFD1_k127_6786279_3	641524.ADICYQ_3013	9.656e-90	316.0	COG0673@1|root,COG3733@1|root,COG0673@2|Bacteria,COG3733@2|Bacteria,4NN43@976|Bacteroidetes,47UBC@768503|Cytophagia	976|Bacteroidetes	Q	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_6786279_2	880072.Desac_2382	1.098e-116	391.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	Sodium calcium exchanger membrane	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HFD1_k127_6786279_4	1232410.KI421426_gene1504	1.571e-41	157.0	2DXYD@1|root,3476T@2|Bacteria,1NCGD@1224|Proteobacteria	1224|Proteobacteria	S	Sugar efflux transporter for intercellular exchange	-	-	-	-	-	-	-	-	-	-	-	-	MtN3_slv
HFD1_k127_6786279_5	1382359.JIAL01000001_gene1291	6.321e-11	67.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_680056_1	234267.Acid_3320	6.683e-63	224.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_680056_0	234267.Acid_3320	5.626e-121	405.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_680056_2	1183438.GKIL_4354	8.611e-50	188.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6813511_4	204669.Acid345_0687	1.406e-53	199.0	COG0145@1|root,COG1933@1|root,COG0145@2|Bacteria,COG1933@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease I activity	apc3	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	AAA_16,DZR,Guanylate_cyc,Hydant_A_N,Hydantoinase_A,Hydantoinase_B,MutL
HFD1_k127_6813511_1	234267.Acid_6350	4.346e-138	448.0	COG0584@1|root,COG0584@2|Bacteria,3Y386@57723|Acidobacteria	57723|Acidobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6813511_2	234267.Acid_4531	3.406e-82	280.0	COG1387@1|root,COG1387@2|Bacteria,3Y6GG@57723|Acidobacteria	57723|Acidobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_6813511_3	797209.ZOD2009_13666	5.705e-59	223.0	arCOG02387@1|root,arCOG02387@2157|Archaea,2Y149@28890|Euryarchaeota,240V2@183963|Halobacteria	183963|Halobacteria	T	COG0784 FOG CheY-like receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_6813511_5	234267.Acid_4750	3.413e-42	165.0	COG1917@1|root,COG1917@2|Bacteria,3Y5JM@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_6813511_6	1267535.KB906767_gene5038	2.787e-08	65.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria,2JI98@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_6813511_0	234267.Acid_4272	1.838e-140	450.0	COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_6820171_1	234267.Acid_6479	2.94e-109	373.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria	234267.Acid_6479|-	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6820171_0	1340493.JNIF01000003_gene3446	9.584e-191	599.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD1_k127_6825705_1	251221.35211983	2.675e-40	156.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_6825705_0	234267.Acid_2316	6.1e-109	361.0	COG2304@1|root,COG2304@2|Bacteria,3Y6C6@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HFD1_k127_6825705_2	1120950.KB892708_gene4551	6.528e-10	72.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
HFD1_k127_6830703_1	234267.Acid_7601	1.92e-172	548.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria	57723|Acidobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD1_k127_6830703_4	8153.XP_005924079.1	1.651e-70	249.0	COG0434@1|root,2QUBS@2759|Eukaryota,38EZC@33154|Opisthokonta,3BES3@33208|Metazoa,3D0S4@33213|Bilateria,47ZQG@7711|Chordata,4905V@7742|Vertebrata,49RCN@7898|Actinopterygii	33208|Metazoa	S	Zgc 162297	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
HFD1_k127_6830703_0	518766.Rmar_0585	1.027e-190	618.0	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes	976|Bacteroidetes	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD1_k127_6830703_3	278963.ATWD01000001_gene2469	1.653e-107	360.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD1_k127_6830703_2	234267.Acid_6776	2.537e-118	398.0	COG0346@1|root,COG0346@2|Bacteria,3Y4RM@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_6831137_17	1267535.KB906767_gene230	2.486e-24	113.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
HFD1_k127_6831137_2	234267.Acid_2600	3.258e-176	556.0	COG2404@1|root,COG2404@2|Bacteria,3Y98M@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831137_13	1122925.KB895379_gene2240	1.051e-38	154.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,26QEM@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08950,iYO844.BSU23270	Lum_binding
HFD1_k127_6831137_1	234267.Acid_4222	1.652e-185	584.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3Y2WU@57723|Acidobacteria	57723|Acidobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD1_k127_6831137_3	234267.Acid_4221	7.439e-168	531.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HFD1_k127_6831137_5	234267.Acid_4165	5.334e-128	432.0	COG0451@1|root,COG0451@2|Bacteria,3Y7GG@57723|Acidobacteria	57723|Acidobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HFD1_k127_6831137_12	234267.Acid_1351	1.261e-52	192.0	2ADQJ@1|root,313FX@2|Bacteria,3Y7U5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831137_16	234267.Acid_1350	2.585e-31	126.0	2DQJB@1|root,3377V@2|Bacteria,3Y8JD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831137_4	234267.Acid_1799	1.137e-131	423.0	COG0384@1|root,COG0384@2|Bacteria,3Y7JN@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Phenazine biosynthesis PhzC PhzF protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HFD1_k127_6831137_9	1340493.JNIF01000003_gene1291	1.45e-105	362.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	gnnB	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2351	DegT_DnrJ_EryC1
HFD1_k127_6831137_6	234267.Acid_1802	2.356e-113	374.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,PMT_2
HFD1_k127_6831137_10	234267.Acid_1803	1.393e-94	325.0	COG0500@1|root,COG2226@2|Bacteria,3Y8WR@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_6831137_8	1340493.JNIF01000003_gene1290	4.696e-111	372.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784,ko:K13318,ko:K13322,ko:K16439,ko:K19857	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793,M00798,M00799,M00800	R00291,R02984,R06436,R06513,R06629,R11042,R11047	RC00182,RC00261,RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD1_k127_6831137_7	234267.Acid_1804	1.46e-112	374.0	COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria	57723|Acidobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD1_k127_6831137_11	234267.Acid_1805	1.514e-71	251.0	COG0457@1|root,COG0457@2|Bacteria,3Y5WJ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831137_0	234267.Acid_1806	2.02e-199	632.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_6831667_4	1535422.ND16A_1058	0.0007445	47.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria,1S7BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_6831667_1	1278073.MYSTI_02425	2.176e-45	168.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_6831667_2	1254432.SCE1572_08395	1.098e-38	165.0	COG2911@1|root,COG2911@2|Bacteria,1N4HK@1224|Proteobacteria,438QH@68525|delta/epsilon subdivisions,2X912@28221|Deltaproteobacteria,2YXIA@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831667_0	266265.Bxe_C0490	1.627e-101	343.0	COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	Transposase_20
HFD1_k127_6831903_1	234267.Acid_7859	3.012e-136	440.0	COG1565@1|root,COG1565@2|Bacteria,3Y583@57723|Acidobacteria	57723|Acidobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD1_k127_6831903_3	234267.Acid_7858	5.987e-43	158.0	2C8EQ@1|root,3497J@2|Bacteria,3Y8QF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6831903_0	234267.Acid_7856	5.092e-157	497.0	COG0305@1|root,COG0305@2|Bacteria,3Y335@57723|Acidobacteria	57723|Acidobacteria	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD1_k127_6857273_2	234267.Acid_0489	7.116e-51	181.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD1_k127_6857273_0	234267.Acid_0490	0.0	1576.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
HFD1_k127_6857273_1	234267.Acid_0491	1.895e-96	317.0	COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD1_k127_6857476_2	909663.KI867150_gene971	1.091e-28	121.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_6857476_3	234267.Acid_2471	1.949e-20	98.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_2471|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_6857476_4	234267.Acid_7679	0.0004406	49.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_6857476_0	234267.Acid_1441	1.553e-131	429.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_6857476_1	234267.Acid_1440	8.08e-103	342.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
HFD1_k127_6859643_0	234267.Acid_7871	5.696e-267	831.0	COG0616@1|root,COG0616@2|Bacteria,3Y3M1@57723|Acidobacteria	57723|Acidobacteria	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD1_k127_6859643_1	234267.Acid_7873	2.529e-236	737.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_6859643_2	234267.Acid_7874	2.37e-82	277.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_6868531_5	1267535.KB906767_gene5504	1.619e-33	133.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_6868531_8	1267533.KB906738_gene2281	0.000858	52.0	COG3391@1|root,COG3391@2|Bacteria,3Y3M8@57723|Acidobacteria,2JIG3@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6868531_6	234267.Acid_0847	2.425e-19	103.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Kelch_4
HFD1_k127_6868531_2	234267.Acid_5693	8.024e-118	385.0	COG1234@1|root,COG1234@2|Bacteria,3Y7KR@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD1_k127_6868531_4	234267.Acid_2174	3.964e-67	242.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Calx-beta,F5_F8_type_C,PA14,RicinB_lectin_2,Ricin_B_lectin,SdrD_B
HFD1_k127_6868531_3	1267535.KB906767_gene5132	5.542e-91	326.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_6868531_0	234267.Acid_2691	6.131e-225	702.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_6868531_1	1267535.KB906767_gene4866	5.618e-130	422.0	COG2863@1|root,COG2863@2|Bacteria	2|Bacteria	C	cytochrome	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3,DUF1566
HFD1_k127_6868531_7	1340493.JNIF01000003_gene2091	3.769e-09	61.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y708@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD1_k127_6888690_2	1340493.JNIF01000003_gene3517	3.406e-82	280.0	COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_6888690_1	234267.Acid_6309	4.71e-139	447.0	COG1091@1|root,COG1091@2|Bacteria,3Y3IG@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HFD1_k127_6888690_0	234267.Acid_0769	0.0	1338.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,3Y61D@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HFD1_k127_6888690_4	234267.Acid_0767	2.706e-37	143.0	COG0636@1|root,COG0636@2|Bacteria,3Y59E@57723|Acidobacteria	57723|Acidobacteria	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD1_k127_6889214_1	1210884.HG799464_gene11157	3.88e-31	125.0	COG1570@1|root,COG1570@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD1_k127_6889214_0	886293.Sinac_1231	3.09e-112	381.0	COG3464@1|root,COG3464@2|Bacteria,2J4EX@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6894050_0	234267.Acid_4173	1.479e-138	454.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_6894050_1	1267535.KB906767_gene2445	1.737e-95	323.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria,2JJCF@204432|Acidobacteriia	204432|Acidobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HFD1_k127_6894050_2	234267.Acid_6670	8.756e-30	119.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD1_k127_6920963_0	234267.Acid_3848	2.247e-286	893.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HFD1_k127_6920963_4	234267.Acid_3847	6.759e-63	221.0	COG1434@1|root,COG1434@2|Bacteria,3Y8M4@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD1_k127_6920963_3	234267.Acid_3846	1.03e-95	316.0	2FCIR@1|root,344N3@2|Bacteria,3Y8MF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6920963_5	234267.Acid_3845	3.981e-48	199.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD1_k127_6920963_2	1340493.JNIF01000004_gene391	1.586e-179	573.0	COG3875@1|root,COG3875@2|Bacteria,3Y6SH@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HFD1_k127_6920963_1	234267.Acid_7648	1.83e-259	807.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6
HFD1_k127_6948400_1	234267.Acid_5762	4.04e-189	592.0	COG1139@1|root,COG1139@2|Bacteria,3Y3R8@57723|Acidobacteria	57723|Acidobacteria	C	cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
HFD1_k127_6948400_3	234267.Acid_5761	5.185e-83	287.0	COG1556@1|root,COG1556@2|Bacteria,3Y5T6@57723|Acidobacteria	57723|Acidobacteria	S	Pfam:DUF162	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HFD1_k127_6948400_4	234267.Acid_0808	6.187e-54	210.0	COG3858@1|root,COG3858@2|Bacteria,3Y46G@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HFD1_k127_6948400_0	1340493.JNIF01000003_gene2760	0.0	1395.0	COG2067@1|root,COG2067@2|Bacteria,3Y41G@57723|Acidobacteria	57723|Acidobacteria	I	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_6948400_5	926566.Terro_2604	6.571e-08	61.0	COG1629@1|root,COG1629@2|Bacteria,3Y2ZU@57723|Acidobacteria,2JHPF@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_6948400_2	1267533.KB906733_gene3215	6.616e-177	587.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD1_k127_6964093_4	234267.Acid_2756	6.415e-45	165.0	COG2755@1|root,COG2755@2|Bacteria,3Y2KK@57723|Acidobacteria	2|Bacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD1_k127_6964093_0	234267.Acid_7007	0.0	1148.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	GHL10,GHL6,Glyco_hydro_42M,Polysacc_deac_1
HFD1_k127_6964093_2	243231.GSU0205	3.726e-72	249.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,42VHH@68525|delta/epsilon subdivisions,2WRQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HFD1_k127_6964093_1	243231.GSU0204	1.677e-178	570.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,42RM5@68525|delta/epsilon subdivisions,2WNP2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_6964093_3	1340493.JNIF01000003_gene1928	4.087e-45	169.0	COG1629@1|root,COG1629@2|Bacteria,3Y2FQ@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_6973937_9	1267535.KB906767_gene3097	1.264e-127	419.0	COG0530@1|root,COG0530@2|Bacteria	2|Bacteria	P	calcium, potassium:sodium antiporter activity	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HFD1_k127_6973937_1	234267.Acid_7341	1.932e-211	666.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD1_k127_6973937_5	234267.Acid_7344	1.588e-174	556.0	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HFD1_k127_6973937_11	234267.Acid_7345	7.999e-98	347.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD1_k127_6973937_25	1177154.Y5S_02266	4.968e-05	51.0	COG4961@1|root,COG4961@2|Bacteria,1NBHW@1224|Proteobacteria	1224|Proteobacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD1_k127_6973937_23	234267.Acid_6528	1.363e-22	104.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD1_k127_6973937_17	234267.Acid_6529	9.286e-40	162.0	COG4655@1|root,COG4655@2|Bacteria	2|Bacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD1_k127_6973937_18	234267.Acid_7501	4.718e-38	149.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,TadE
HFD1_k127_6973937_8	234267.Acid_7503	8.39e-133	436.0	COG4655@1|root,COG4655@2|Bacteria,3Y5CX@57723|Acidobacteria	57723|Acidobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD1_k127_6973937_21	234267.Acid_4540	3.655e-25	111.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Cna_B,FctA,Tad,VWA,VWA_2
HFD1_k127_6973937_14	1122919.KB905564_gene2610	5.004e-64	228.0	COG1028@1|root,COG1028@2|Bacteria,1TSNP@1239|Firmicutes,4IPV4@91061|Bacilli,26RT2@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_6973937_4	234267.Acid_7221	8.308e-181	573.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_6973937_2	234267.Acid_7350	6.587e-189	594.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria	57723|Acidobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD1_k127_6973937_13	234267.Acid_7349	2.105e-85	287.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD1_k127_6973937_20	1267535.KB906767_gene3600	3.449e-28	134.0	COG4031@1|root,COG4031@2|Bacteria,3Y8JK@57723|Acidobacteria	57723|Acidobacteria	S	Predicted metal-binding protein (DUF2103)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2103
HFD1_k127_6973937_7	234267.Acid_0811	1.05e-137	443.0	COG1082@1|root,COG1082@2|Bacteria,3Y88X@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_6973937_24	118005.AWNK01000010_gene411	1.692e-05	55.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF4440,SnoaL_2,SnoaL_3,YkuD
HFD1_k127_6973937_12	234267.Acid_0810	2.628e-92	306.0	2F161@1|root,33U75@2|Bacteria,3Y7M8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6973937_6	234267.Acid_0809	6.387e-154	491.0	COG1940@1|root,COG1940@2|Bacteria,3Y4DD@57723|Acidobacteria	57723|Acidobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD1_k127_6973937_19	234267.Acid_5286	2.509e-33	146.0	COG0810@1|root,COG0810@2|Bacteria,3Y8HF@57723|Acidobacteria	57723|Acidobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6973937_0	234267.Acid_0351	0.0	1009.0	COG3250@1|root,COG3250@2|Bacteria,3Y48R@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glyco_hydro_2_N
HFD1_k127_6973937_3	234267.Acid_0350	2.854e-181	574.0	COG2723@1|root,COG2723@2|Bacteria,3Y5XS@57723|Acidobacteria	57723|Acidobacteria	G	6-phospho-beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6973937_10	234267.Acid_6198	2.275e-115	376.0	COG0457@1|root,COG3342@1|root,COG0457@2|Bacteria,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HFD1_k127_6975680_0	234267.Acid_0197	9.073e-131	428.0	COG5616@1|root,COG5616@2|Bacteria,3Y4NN@57723|Acidobacteria	57723|Acidobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6975680_1	1340493.JNIF01000003_gene3438	2.357e-82	282.0	COG2017@1|root,COG2017@2|Bacteria,3Y6TJ@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6982891_3	234267.Acid_5318	1.197e-102	337.0	COG0377@1|root,COG0377@2|Bacteria,3Y475@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD1_k127_6982891_0	234267.Acid_5317	0.0	1066.0	COG1640@1|root,COG1640@2|Bacteria,3Y6TQ@57723|Acidobacteria	57723|Acidobacteria	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD1_k127_6982891_2	234267.Acid_7043	3.508e-125	404.0	COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07662	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_6982891_1	234267.Acid_7044	5.923e-209	664.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,3Y4NJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_6982891_5	234267.Acid_1246	1.77e-18	89.0	2DMID@1|root,32RSF@2|Bacteria,3Y82Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_698541_0	234267.Acid_5952	3.375e-191	638.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_698541_1	1340493.JNIF01000003_gene2863	1.441e-21	102.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061,ko:K06889	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Asp_protease_2,Chlorophyllase2,DLH
HFD1_k127_6997042_0	1041146.ATZB01000034_gene559	3.433e-169	539.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,4BD23@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_6997042_1	1150398.JIBJ01000006_gene3516	1.044e-31	127.0	2ANI9@1|root,31DH5@2|Bacteria,2GJE8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7020313_0	1118054.CAGW01000009_gene3934	1.218e-92	310.0	COG1231@1|root,COG1231@2|Bacteria,1VM1Q@1239|Firmicutes,4HS2U@91061|Bacilli,26WD3@186822|Paenibacillaceae	91061|Bacilli	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD1_k127_7020313_1	234267.Acid_5767	9.836e-75	260.0	2C730@1|root,32UQY@2|Bacteria,3Y59Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7020313_3	234267.Acid_7217	3.776e-12	72.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7020313_2	443144.GM21_0944	5.872e-44	179.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD1_k127_7020313_4	1449355.JQNR01000002_gene6139	1.274e-07	64.0	COG0500@1|root,COG2226@2|Bacteria,2IC4V@201174|Actinobacteria	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_7045922_2	1250232.JQNJ01000001_gene462	4.861e-17	83.0	COG4124@1|root,COG4124@2|Bacteria,4NIAN@976|Bacteroidetes,1I940@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 26	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Big_5,CBM_35,Glyco_hydro_26
HFD1_k127_7045922_0	1340493.JNIF01000003_gene3123	8.098e-126	411.0	COG1858@1|root,COG1858@2|Bacteria,3Y46D@57723|Acidobacteria	57723|Acidobacteria	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD1_k127_7045922_1	1089547.KB913013_gene1278	1.126e-55	201.0	COG3458@1|root,COG3458@2|Bacteria,4NGH5@976|Bacteroidetes,47MHG@768503|Cytophagia	976|Bacteroidetes	Q	PFAM Acetyl xylan esterase	axe7A_2	-	-	-	-	-	-	-	-	-	-	-	AXE1
HFD1_k127_7048710_1	234267.Acid_7539	5.3e-40	151.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria	57723|Acidobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_7048710_0	234267.Acid_4267	1.452e-275	871.0	COG0577@1|root,COG0577@2|Bacteria,3Y3U3@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7056098_10	1123242.JH636435_gene2640	1.044e-26	113.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	MA20_16785	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7056098_11	1123057.P872_18730	2.486e-24	113.0	COG1082@1|root,COG1082@2|Bacteria,4NM4N@976|Bacteroidetes,47PXI@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7056098_7	234267.Acid_7102	4.861e-52	198.0	COG1073@1|root,COG1073@2|Bacteria,3Y6D7@57723|Acidobacteria	57723|Acidobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
HFD1_k127_7056098_3	234267.Acid_7102	7.822e-98	327.0	COG1073@1|root,COG1073@2|Bacteria,3Y6D7@57723|Acidobacteria	57723|Acidobacteria	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
HFD1_k127_7056098_6	234267.Acid_6347	2.229e-56	199.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_7056098_2	234267.Acid_6348	8.96e-116	392.0	COG4219@1|root,COG4219@2|Bacteria,3Y5DY@57723|Acidobacteria	57723|Acidobacteria	KT	PFAM Peptidase M56, BlaR1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
HFD1_k127_7056098_4	234267.Acid_6349	5.268e-87	302.0	COG4219@1|root,COG4219@2|Bacteria,3Y5D9@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7056098_9	70448.A0A090M5V9	1.812e-43	166.0	2C8MV@1|root,2S34S@2759|Eukaryota,37VJ6@33090|Viridiplantae,34I3H@3041|Chlorophyta	3041|Chlorophyta	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD1_k127_7056098_1	1340493.JNIF01000003_gene1785	2.55e-150	484.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_7056098_0	234267.Acid_4563	1.695e-174	554.0	COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria	57723|Acidobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_7056098_5	234267.Acid_2363	5.222e-59	211.0	COG1309@1|root,COG1309@2|Bacteria,3Y8G6@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD1_k127_7056098_8	234267.Acid_2364	3.377e-50	192.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_7085603_9	234267.Acid_3274	4.722e-45	166.0	COG0631@1|root,COG0631@2|Bacteria,3Y4SV@57723|Acidobacteria	57723|Acidobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD1_k127_7085603_3	234267.Acid_3275	5.323e-139	458.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_3275|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7085603_0	234267.Acid_3276	0.0	1349.0	COG0768@1|root,COG0772@1|root,COG0768@2|Bacteria,COG0772@2|Bacteria	2|Bacteria	D	peptidoglycan glycosyltransferase activity	pbpA	GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588,ko:K05364,ko:K05837	ko00550,ko04112,map00550,map04112	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE,Transpeptidase
HFD1_k127_7085603_7	234267.Acid_3277	1.886e-90	311.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HFD1_k127_7085603_11	344747.PM8797T_12733	4.466e-29	134.0	COG0457@1|root,COG0457@2|Bacteria,2J3ZR@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7085603_12	1123393.KB891328_gene610	1.665e-24	119.0	COG0526@1|root,COG0526@2|Bacteria,1PHN8@1224|Proteobacteria,2W9SP@28216|Betaproteobacteria,1KSFG@119069|Hydrogenophilales	119069|Hydrogenophilales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_7085603_13	306281.AJLK01000150_gene1983	3.732e-11	66.0	2FI08@1|root,349T6@2|Bacteria,1GF2Y@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7085603_10	102232.GLO73106DRAFT_00014140	1.972e-41	156.0	COG1848@1|root,COG1848@2|Bacteria,1G6FV@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD1_k127_7085603_1	234267.Acid_0848	3.038e-297	919.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,3Y2SH@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase X	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HFD1_k127_7085603_8	234267.Acid_0849	5.721e-72	270.0	COG0494@1|root,COG0494@2|Bacteria,3Y4N9@57723|Acidobacteria	57723|Acidobacteria	L	PFAM NUDIX hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HFD1_k127_7085603_4	234267.Acid_5494	3.708e-121	394.0	COG3622@1|root,COG3622@2|Bacteria,3Y6XP@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_7085603_2	234267.Acid_0850	1.206e-220	689.0	COG0389@1|root,COG0389@2|Bacteria,3Y3NY@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD1_k127_7085603_5	234267.Acid_0853	1.043e-114	380.0	COG0842@1|root,COG0842@2|Bacteria,3Y4YG@57723|Acidobacteria	57723|Acidobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD1_k127_7085603_6	234267.Acid_0854	4.313e-101	331.0	COG1131@1|root,COG1131@2|Bacteria,3Y3PY@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_7088207_0	1340493.JNIF01000003_gene3197	1.672e-162	524.0	COG0308@1|root,COG0308@2|Bacteria,3Y6V6@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HFD1_k127_7088207_1	671143.DAMO_0966	3.676e-154	503.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	spoIVFB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
HFD1_k127_7088207_2	765869.BDW_11285	3.152e-120	396.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,42PJP@68525|delta/epsilon subdivisions,2MTGD@213481|Bdellovibrionales,2WJI0@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	membrane protein, TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HFD1_k127_7088207_5	292415.Tbd_1197	3.693e-26	111.0	COG3809@1|root,COG3809@2|Bacteria,1N6ZY@1224|Proteobacteria,2VW4E@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HFD1_k127_7088207_3	316067.Geob_1777	3.618e-96	324.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43T22@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD1_k127_7126107_2	234267.Acid_6727	1.182e-183	581.0	COG2239@1|root,COG2239@2|Bacteria,3Y3WD@57723|Acidobacteria	57723|Acidobacteria	P	MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
HFD1_k127_7126107_0	234267.Acid_0759	0.0	1475.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2920,Peptidase_S9
HFD1_k127_7126107_4	234267.Acid_2432	1.525e-43	167.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD1_k127_7126107_1	234267.Acid_0758	5.727e-185	581.0	COG0031@1|root,COG0031@2|Bacteria,3Y39M@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_7126107_3	234267.Acid_0757	7.794e-50	180.0	COG1310@1|root,COG1310@2|Bacteria,3Y4PH@57723|Acidobacteria	57723|Acidobacteria	S	Mov34 MPN PAD-1	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HFD1_k127_7157551_2	234267.Acid_5203	8.334e-96	319.0	COG0276@1|root,COG0276@2|Bacteria,3Y3B0@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD1_k127_7157551_1	234267.Acid_5204	2.112e-218	685.0	COG1232@1|root,COG1232@2|Bacteria,3Y2X5@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_7157551_0	234267.Acid_1966	7.389e-290	932.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_7157551_4	234267.Acid_4321	5.968e-07	56.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_7181769_1	1449049.JONW01000005_gene1181	3.582e-86	291.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2TV8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_7181769_0	1449049.JONW01000005_gene1182	0.0	1240.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2TT7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HFD1_k127_7207215_7	700598.Niako_2100	2.519e-65	231.0	COG3023@1|root,COG3023@2|Bacteria	2|Bacteria	V	N-Acetylmuramoyl-L-alanine amidase	-	-	3.2.1.3,3.2.1.52,3.5.1.28	ko:K01207,ko:K01447,ko:K11066,ko:K21574	ko00500,ko00520,ko00531,ko01100,ko01501,map00500,map00520,map00531,map01100,map01501	M00628	R00022,R01790,R01791,R04112,R05963,R07809,R07810,R10831	RC00049,RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011	-	GH97	-	Amidase_2,PG_binding_1
HFD1_k127_7207215_17	1340493.JNIF01000003_gene2546	4.502e-27	127.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7207215_12	234267.Acid_7760	4.59e-41	153.0	COG0184@1|root,COG0184@2|Bacteria,3Y5R5@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal_S15	-	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD1_k127_7207215_0	234267.Acid_7759	0.0	1184.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria	57723|Acidobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HFD1_k127_7207215_9	234267.Acid_7289	1.513e-58	228.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_7207215_8	234267.Acid_7289	3.325e-60	223.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD1_k127_7207215_19	671143.DAMO_0917	3.246e-10	62.0	COG0615@1|root,COG0615@2|Bacteria,2NRS5@2323|unclassified Bacteria	2|Bacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD1_k127_7207215_15	671143.DAMO_0917	1.14e-29	125.0	COG0615@1|root,COG0615@2|Bacteria,2NRS5@2323|unclassified Bacteria	2|Bacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD1_k127_7207215_21	118166.JH976537_gene850	1.351e-05	55.0	COG0615@1|root,COG0615@2|Bacteria,1G8ZG@1117|Cyanobacteria,1HC32@1150|Oscillatoriales	1117|Cyanobacteria	IM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD1_k127_7207215_6	1340493.JNIF01000003_gene4366	3.399e-92	312.0	COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HFD1_k127_7207215_14	1348657.M622_17245	3.527e-31	137.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,GUN4,GUN4_N,Peptidase_C13,Peptidase_C14
HFD1_k127_7207215_2	700598.Niako_0762	4.478e-236	745.0	COG5297@1|root,COG5297@2|Bacteria,4PKPX@976|Bacteroidetes,1IV41@117747|Sphingobacteriia	976|Bacteroidetes	G	Fg-gap repeat	-	-	4.2.2.23	ko:K18197	-	-	-	-	ko00000,ko01000	-	PL11	-	-
HFD1_k127_7207215_4	1196323.ALKF01000197_gene2303	6.653e-108	357.0	COG0667@1|root,COG0667@2|Bacteria,1TRHN@1239|Firmicutes,4H9ZV@91061|Bacilli,26RRE@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_7207215_18	859657.RPSI07_2290	1.248e-19	96.0	COG3631@1|root,COG3631@2|Bacteria,1NBTW@1224|Proteobacteria,2WE9Y@28216|Betaproteobacteria,1KFUS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HFD1_k127_7207215_5	234267.Acid_7291	2.099e-107	354.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7207215_1	234267.Acid_7295	0.0	1158.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HFD1_k127_7207215_3	234267.Acid_7297	3.621e-182	575.0	COG0322@1|root,COG0322@2|Bacteria,3Y3HU@57723|Acidobacteria	57723|Acidobacteria	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7207215_16	467200.ACFA01000530_gene4258	8.063e-28	132.0	COG1434@1|root,COG1434@2|Bacteria,2GTZ7@201174|Actinobacteria	201174|Actinobacteria	S	DUF218 domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF218
HFD1_k127_7207215_13	234267.Acid_0107	2.476e-37	143.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria	57723|Acidobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD1_k127_7207215_10	234267.Acid_7299	2.995e-54	192.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_7220698_2	234267.Acid_0593	7.501e-88	295.0	28JXN@1|root,30T38@2|Bacteria,3Y61P@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_7220698_0	234267.Acid_0594	3.223e-179	566.0	COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_7220698_1	1464048.JNZS01000025_gene780	5.912e-97	331.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4DA91@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
HFD1_k127_7241131_10	1499967.BAYZ01000147_gene684	2.604e-48	180.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD1_k127_7241131_0	114615.BRADO2172	7.15e-192	608.0	COG3546@1|root,COG3685@1|root,COG3546@2|Bacteria,COG3685@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,3JSPX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Manganese containing catalase	katN	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	DUF892,Mn_catalase
HFD1_k127_7241131_3	234267.Acid_3240	4.071e-104	351.0	COG4589@1|root,COG4589@2|Bacteria,3Y59Y@57723|Acidobacteria	57723|Acidobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD1_k127_7241131_1	234267.Acid_3241	2.25e-154	491.0	COG0020@1|root,COG0020@2|Bacteria,3Y485@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD1_k127_7241131_6	1267535.KB906767_gene2520	1.491e-89	301.0	COG1656@1|root,COG1656@2|Bacteria,3Y7UJ@57723|Acidobacteria	57723|Acidobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HFD1_k127_7241131_2	1132442.KB889752_gene3043	3.076e-131	431.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4HABC@91061|Bacilli,1ZBQS@1386|Bacillus	91061|Bacilli	E	Dehydrogenase	bdhA	GO:0000721,GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06240	ADH_N,ADH_N_assoc,ADH_zinc_N
HFD1_k127_7241131_4	697303.Thewi_2062	8.301e-97	330.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD1_k127_7241131_5	1121428.DESHY_110536___1	7.207e-95	324.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD1_k127_7241131_9	383372.Rcas_2619	1.452e-59	235.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Cu_amine_oxidN1,F5_F8_type_C,IgGFc_binding,PKD
HFD1_k127_7241131_11	382464.ABSI01000011_gene2467	1.034e-39	171.0	COG1082@1|root,COG2982@1|root,COG3291@1|root,COG4733@1|root,COG1082@2|Bacteria,COG2982@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,46Z76@74201|Verrucomicrobia,2IWJ4@203494|Verrucomicrobiae	2|Bacteria	G	Carbohydrate binding domain	susB	GO:0000272,GO:0003674,GO:0003824,GO:0004339,GO:0004553,GO:0004558,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015926,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:0090599,GO:1901575	3.2.1.20,3.2.1.3	ko:K01187,ko:K21574	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01790,R01791,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31,GH97	-	GH97_C,GH97_N,Glyco_hydro_97
HFD1_k127_7241131_8	888821.HMPREF9394_1338	6.263e-63	242.0	COG3525@1|root,COG3525@2|Bacteria,1TSXM@1239|Firmicutes,4I2B1@91061|Bacilli,1WRHS@1305|Streptococcus sanguinis	91061|Bacilli	G	Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20
HFD1_k127_7241131_7	344747.PM8797T_29842	4.205e-89	310.0	COG1073@1|root,COG1073@2|Bacteria,2IWSQ@203682|Planctomycetes	203682|Planctomycetes	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
HFD1_k127_7245944_1	443143.GM18_3570	9.955e-196	614.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_7245944_6	1254432.SCE1572_51135	1.769e-23	115.0	COG0500@1|root,COG1853@1|root,COG1853@2|Bacteria,COG2226@2|Bacteria,1RGYM@1224|Proteobacteria,4346C@68525|delta/epsilon subdivisions,2X20P@28221|Deltaproteobacteria,2Z2GY@29|Myxococcales	28221|Deltaproteobacteria	Q	Flavin reductase like domain	-	-	1.5.1.36	ko:K00484,ko:K16048	ko00350,ko00740,ko00984,ko01100,ko01120,ko01220,map00350,map00740,map00984,map01100,map01120,map01220	-	R02698,R03299,R05705,R09748,R09750,R09819	RC00046,RC00126,RC00236	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct,Methyltransf_11
HFD1_k127_7245944_2	330214.NIDE0029	3.843e-192	622.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
HFD1_k127_7245944_4	443143.GM18_3568	1.484e-171	560.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKE@68525|delta/epsilon subdivisions,2WJTK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_7245944_5	243231.GSU2781	3.948e-154	501.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria,43TCG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HFD1_k127_7245944_0	243231.GSU2782	0.0	1652.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_7245944_3	296591.Bpro_1369	3.134e-191	610.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2VJHX@28216|Betaproteobacteria,4ACRX@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
HFD1_k127_7253138_4	234267.Acid_6290	1.141e-55	199.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_7253138_0	234267.Acid_6290	4.774e-283	905.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_7253138_2	313628.LNTAR_00950	8.894e-102	346.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
HFD1_k127_7253138_1	886293.Sinac_2763	1.675e-112	376.0	COG2382@1|root,COG2382@2|Bacteria,2IYMZ@203682|Planctomycetes	203682|Planctomycetes	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
HFD1_k127_7253138_3	234267.Acid_6141	5.044e-80	279.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CHU_C,DUF1080,PKD
HFD1_k127_7253138_6	28737.XP_006903243.1	7.322e-14	73.0	COG3119@1|root,KOG3867@2759|Eukaryota,39S32@33154|Opisthokonta,3BMWM@33208|Metazoa,3CZED@33213|Bilateria,48CX4@7711|Chordata,49953@7742|Vertebrata,3J5Q7@40674|Mammalia,3580Z@311790|Afrotheria	33208|Metazoa	P	Arylsulfatase F	ARSF	GO:0003674,GO:0003824,GO:0004065,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0008484,GO:0012505,GO:0016787,GO:0016788,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070013	-	ko:K12374	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase,Sulfatase_C
HFD1_k127_7254103_0	234267.Acid_0003	1.35e-246	766.0	COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria	57723|Acidobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD1_k127_7254103_2	234267.Acid_0002	7.31e-201	629.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria	57723|Acidobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD1_k127_7254103_1	234267.Acid_0001	8.48e-236	734.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria	57723|Acidobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD1_k127_7254103_4	234267.Acid_7948	8.951e-78	267.0	2E6AH@1|root,330YD@2|Bacteria,3Y8MQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7254103_3	234267.Acid_7947	8.842e-145	467.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7258165_7	234267.Acid_1989	3.087e-75	259.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD1_k127_7258165_2	234267.Acid_1991	1.226e-153	497.0	COG0457@1|root,COG0457@2|Bacteria,3Y4S2@57723|Acidobacteria	57723|Acidobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HFD1_k127_7258165_0	234267.Acid_1990	0.0	1170.0	COG1629@1|root,COG4771@2|Bacteria,3Y3YH@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_7258165_9	234267.Acid_2698	1.829e-59	210.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7258165_8	234267.Acid_2697	1.869e-61	222.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_7258165_5	380394.Lferr_0203	5.11e-119	398.0	2BZPA@1|root,2ZA2G@2|Bacteria,1NUVQ@1224|Proteobacteria,1SK2E@1236|Gammaproteobacteria,2NDQ1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
HFD1_k127_7258165_1	234267.Acid_5694	2.045e-307	949.0	COG1960@1|root,COG1960@2|Bacteria,3Y2NA@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_7258165_4	1121382.JQKG01000012_gene236	1.285e-126	412.0	COG0205@1|root,COG0205@2|Bacteria,1WM4B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HFD1_k127_7258165_6	1382359.JIAL01000001_gene1878	1.892e-84	293.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	yqhO	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD1_k127_7258165_3	1340493.JNIF01000004_gene24	8.992e-132	427.0	COG1529@1|root,COG1529@2|Bacteria,3Y77V@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD1_k127_7258165_11	1267535.KB906767_gene664	5.63e-10	70.0	COG1082@1|root,COG1082@2|Bacteria,3Y4SF@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl-hydrolase 97 N-terminal	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
HFD1_k127_7280203_1	234267.Acid_2583	7.217e-44	164.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_7280203_0	234267.Acid_4564	4.973e-247	804.0	COG1629@1|root,COG4771@2|Bacteria,3Y6A1@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_7281579_3	234267.Acid_0241	1.073e-08	57.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K11894	-	-	-	-	ko00000,ko02044	3.A.23.1	-	-	DUF3662,FHA
HFD1_k127_7281579_2	886293.Sinac_2404	7.359e-44	164.0	COG4104@1|root,COG4104@2|Bacteria,2J086@203682|Planctomycetes	203682|Planctomycetes	S	PAAR motif	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
HFD1_k127_7281579_0	234267.Acid_5438	1.097e-143	462.0	COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria	57723|Acidobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
HFD1_k127_7281579_1	234267.Acid_0222	6.082e-133	435.0	COG0515@1|root,COG0515@2|Bacteria,3Y6PF@57723|Acidobacteria	57723|Acidobacteria	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD1_k127_7283032_4	100226.SCO3475	1.766e-100	341.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6,4.2.1.8	ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R03033,R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_7283032_2	1298858.AUEL01000017_gene2814	1.795e-163	523.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2U050@28211|Alphaproteobacteria,43I4B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HFD1_k127_7283032_5	234267.Acid_7795	2.46e-81	274.0	COG1595@1|root,COG1595@2|Bacteria,3Y4KQ@57723|Acidobacteria	57723|Acidobacteria	K	region 4 type 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7283032_15	234267.Acid_7794	4.785e-26	111.0	2E5Q2@1|root,330EP@2|Bacteria,3Y5RC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7283032_10	1288494.EBAPG3_18600	5.93e-59	208.0	arCOG13037@1|root,3342X@2|Bacteria,1NT84@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7283032_8	1469613.JT55_13185	7.503e-62	235.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HFD1_k127_7283032_14	1547437.LL06_13530	9.443e-30	126.0	COG5266@1|root,COG5266@2|Bacteria,1RA8J@1224|Proteobacteria,2U5BT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Domain of unknown function (DUF4198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
HFD1_k127_7283032_7	448385.sce7280	2.832e-65	243.0	2DB7W@1|root,2Z7P1@2|Bacteria,1N65F@1224|Proteobacteria,434RW@68525|delta/epsilon subdivisions,2X8ZY@28221|Deltaproteobacteria,2Z17U@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4331
HFD1_k127_7283032_19	1198114.AciX9_3551	0.0007364	48.0	2C2XV@1|root,348CD@2|Bacteria,3Y8PN@57723|Acidobacteria,2JNDP@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7283032_13	204669.Acid345_2100	1.474e-36	151.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_7283032_16	404589.Anae109_4175	5.43e-26	113.0	COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD1_k127_7283032_9	234267.Acid_4277	3.245e-60	222.0	2AU2S@1|root,31JP5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_7283032_3	234267.Acid_1866	4.69e-155	495.0	COG1082@1|root,COG1082@2|Bacteria,3Y70I@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7283032_1	861299.J421_1109	1.807e-303	944.0	COG1132@1|root,COG1132@2|Bacteria,1ZUSI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD1_k127_7283032_0	234267.Acid_4922	0.0	1102.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria	57723|Acidobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD1_k127_7283032_17	682795.AciX8_1275	3.951e-19	102.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_9
HFD1_k127_7283032_11	1210884.HG799463_gene9569	9.69e-49	190.0	COG3356@1|root,COG3356@2|Bacteria,2IXKA@203682|Planctomycetes	203682|Planctomycetes	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
HFD1_k127_7292502_0	861299.J421_0970	6.482e-71	250.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	fes	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
HFD1_k127_7292502_1	861299.J421_0561	2.571e-33	138.0	2CDZB@1|root,3340J@2|Bacteria,1ZU24@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7292502_3	29540.C481_02122	1.444e-11	67.0	COG2259@1|root,arCOG08092@2157|Archaea	2157|Archaea	S	DoxX family	-	-	1.8.5.2	ko:K15977,ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
HFD1_k127_7299082_0	234267.Acid_5932	3.574e-255	802.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7299082_1	234267.Acid_5931	8.748e-96	318.0	COG0730@1|root,COG0730@2|Bacteria,3Y4IM@57723|Acidobacteria	57723|Acidobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_7319155_3	1123267.JONN01000001_gene2022	7.086e-45	162.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,2K5VJ@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD1_k127_7319155_1	1123267.JONN01000001_gene2023	6.322e-89	296.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,2K3WJ@204457|Sphingomonadales	204457|Sphingomonadales	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD1_k127_7319155_2	392499.Swit_4112	1.371e-65	235.0	COG1530@1|root,COG1530@2|Bacteria,1RC15@1224|Proteobacteria,2U5PB@28211|Alphaproteobacteria,2K2AZ@204457|Sphingomonadales	204457|Sphingomonadales	J	ribonuclease E activity	-	-	-	-	-	-	-	-	-	-	-	-	RNase_E_G
HFD1_k127_7319155_4	629773.AORY01000004_gene5	2.046e-18	87.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2VEGK@28211|Alphaproteobacteria,2K7UE@204457|Sphingomonadales	204457|Sphingomonadales	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HFD1_k127_7319155_5	1197906.CAJQ02000003_gene3219	4.847e-09	57.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD1_k127_7319155_0	1163409.UUA_08346	4.084e-186	588.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD1_k127_7330057_1	693977.Deipr_1937	3.922e-62	220.0	COG1028@1|root,COG1028@2|Bacteria,1WIPQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
HFD1_k127_7330057_0	234267.Acid_2410	5.333e-206	642.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HFD1_k127_7330546_24	234267.Acid_6472	2.412e-59	206.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria	57723|Acidobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD1_k127_7330546_21	234267.Acid_6477	1.163e-79	268.0	2F1AE@1|root,33UBD@2|Bacteria,3Y7PJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_9	234267.Acid_5736	5.617e-145	490.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1186,SEC-C
HFD1_k127_7330546_14	234267.Acid_6478	3.006e-135	432.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD1_k127_7330546_18	234267.Acid_6480	9.232e-101	337.0	COG3595@1|root,COG3595@2|Bacteria,3Y5MS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_11	234267.Acid_6481	1.433e-138	441.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_7330546_7	234267.Acid_6482	2.647e-172	551.0	COG0845@1|root,COG0845@2|Bacteria,3Y2FV@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
HFD1_k127_7330546_17	234267.Acid_3916	2.814e-104	346.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_7330546_6	234267.Acid_6483	3.121e-174	564.0	COG1538@1|root,COG1538@2|Bacteria,3Y7Q2@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_7330546_1	234267.Acid_6484	5.261e-234	728.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_7330546_2	234267.Acid_6485	4.228e-212	680.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	lprD	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	HlyD_3
HFD1_k127_7330546_3	234267.Acid_6486	5.921e-202	635.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
HFD1_k127_7330546_5	234267.Acid_6487	1.328e-187	597.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD1_k127_7330546_10	234267.Acid_6489	2.924e-142	455.0	COG1354@1|root,COG1354@2|Bacteria,3Y458@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD1_k127_7330546_19	234267.Acid_6490	1.3e-93	320.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD1_k127_7330546_15	234267.Acid_6491	1.731e-110	363.0	COG1187@1|root,COG1187@2|Bacteria,3Y3CQ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD1_k127_7330546_23	234267.Acid_6492	1.805e-60	219.0	COG1832@1|root,COG1832@2|Bacteria,3Y566@57723|Acidobacteria	57723|Acidobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD1_k127_7330546_20	234267.Acid_4468	5.51e-92	322.0	2CDZB@1|root,2ZBFS@2|Bacteria,3Y5HH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_25	234267.Acid_5516	3.349e-57	213.0	COG3153@1|root,COG3153@2|Bacteria,3Y4UU@57723|Acidobacteria	57723|Acidobacteria	S	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_7330546_31	204669.Acid345_1509	0.0001157	47.0	293PJ@1|root,2ZR58@2|Bacteria,3Y96W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_30	1340493.JNIF01000003_gene4233	3.146e-06	59.0	293PJ@1|root,2ZR58@2|Bacteria,3Y96W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_16	234267.Acid_4350	5.43e-109	359.0	COG0560@1|root,COG0560@2|Bacteria,3Y6IV@57723|Acidobacteria	57723|Acidobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD1_k127_7330546_4	1340493.JNIF01000003_gene2245	2.645e-193	607.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_7330546_26	234267.Acid_3670	1.905e-54	203.0	COG2318@1|root,COG2318@2|Bacteria,3Y4U3@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_7330546_13	1340493.JNIF01000003_gene2877	2.691e-137	464.0	COG0666@1|root,COG0666@2|Bacteria,3Y6UE@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
HFD1_k127_7330546_0	234267.Acid_1992	2.208e-307	954.0	COG1680@1|root,COG1680@2|Bacteria,3Y8A8@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_7330546_12	234267.Acid_5186	2.855e-138	454.0	COG0488@1|root,COG0488@2|Bacteria,3Y340@57723|Acidobacteria	2|Bacteria	S	PFAM ABC transporter	yjjK	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran
HFD1_k127_7330546_8	1340493.JNIF01000004_gene393	3.281e-159	518.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD1_k127_7330546_28	1173024.KI912149_gene5114	1.926e-23	104.0	COG2442@1|root,COG2442@2|Bacteria,1GI2S@1117|Cyanobacteria,1JMKD@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD1_k127_7330546_27	1173024.KI912149_gene5115	3.801e-26	111.0	COG4634@1|root,COG4634@2|Bacteria,1G760@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7330546_22	521674.Plim_0518	3.002e-73	248.0	COG4102@1|root,COG4102@2|Bacteria,2J4YY@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_7344287_0	159087.Daro_0209	1.631e-169	544.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,2KU7U@206389|Rhodocyclales	206389|Rhodocyclales	M	penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HFD1_k127_7344287_1	1163617.SCD_n02941	4.484e-75	256.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HFD1_k127_7350946_5	1340493.JNIF01000003_gene3565	8.151e-164	530.0	COG1984@1|root,COG1984@2|Bacteria,3Y9AB@57723|Acidobacteria	57723|Acidobacteria	E	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_7350946_14	1340493.JNIF01000004_gene812	1.034e-28	127.0	COG4976@1|root,COG4976@2|Bacteria	2|Bacteria	O	Methyltransferase	-	-	-	ko:K16437,ko:K20331,ko:K21336	ko00523,ko01055,ko01130,ko02024,map00523,map01055,map01130,map02024	-	R06627,R11466	RC00003,RC01654,RC03444	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_25
HFD1_k127_7350946_1	1340493.JNIF01000004_gene889	2.217e-223	706.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_7350946_2	1340493.JNIF01000004_gene890	2.936e-208	669.0	COG2010@1|root,COG3695@1|root,COG2010@2|Bacteria,COG3695@2|Bacteria,3Y5FU@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
HFD1_k127_7350946_10	234267.Acid_2075	2.691e-68	252.0	COG3356@1|root,COG3356@2|Bacteria,3Y5I7@57723|Acidobacteria	57723|Acidobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
HFD1_k127_7350946_12	1444711.CCJF01000004_gene2369	3.073e-41	176.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,SBBP
HFD1_k127_7350946_17	1340493.JNIF01000003_gene2726	3.206e-11	78.0	COG1470@1|root,COG4625@1|root,COG1470@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,CarboxypepD_reg,DUF11,He_PIG,Kelch_1,NPCBM_assoc,VCBS
HFD1_k127_7350946_11	234267.Acid_1341	5.54e-42	163.0	COG0454@1|root,COG0456@2|Bacteria,3Y5H6@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_7350946_0	234267.Acid_0830	0.0	1009.0	COG2936@1|root,COG2936@2|Bacteria,3Y2WR@57723|Acidobacteria	57723|Acidobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD1_k127_7350946_6	234267.Acid_7267	3.115e-147	492.0	COG4485@1|root,COG4485@2|Bacteria,3Y74P@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD1_k127_7350946_3	1343739.PAP_02800	3.554e-176	565.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
HFD1_k127_7350946_15	1232410.KI421412_gene149	4.915e-27	115.0	COG1371@1|root,COG1371@2|Bacteria,1NCP6@1224|Proteobacteria,42VQE@68525|delta/epsilon subdivisions,2WS6C@28221|Deltaproteobacteria,43VMN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HFD1_k127_7350946_7	234267.Acid_5905	1.496e-143	458.0	COG1082@1|root,COG1082@2|Bacteria,3Y7EJ@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7350946_4	234267.Acid_5906	4.756e-167	531.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_7350946_16	446470.Snas_0813	3.738e-12	78.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD1_k127_7350946_9	502025.Hoch_3763	3.569e-73	260.0	COG0272@1|root,COG0515@1|root,COG0272@2|Bacteria,COG0515@2|Bacteria	2|Bacteria	KLT	protein kinase activity	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	2.7.7.7,6.5.1.2	ko:K01972,ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378,R00382	RC00005,RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5,RNase_T
HFD1_k127_7350946_8	234267.Acid_0693	3.787e-124	404.0	COG0657@1|root,COG0657@2|Bacteria,3Y88B@57723|Acidobacteria	57723|Acidobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_7350946_18	1123023.JIAI01000011_gene8941	0.0003164	47.0	2CBZI@1|root,339ZR@2|Bacteria,2H81E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7350946_13	234267.Acid_7539	5.046e-32	128.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria	57723|Acidobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_7365077_1	234267.Acid_2628	6.058e-87	289.0	COG4948@1|root,COG4948@2|Bacteria,3Y46A@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Mandelate racemase muconate lactonizing enzyme, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
HFD1_k127_7365077_2	28072.Nos7524_4505	7.821e-68	237.0	COG5634@1|root,COG5634@2|Bacteria,1G45V@1117|Cyanobacteria,1HMP8@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterized conserved protein (DUF2278)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2278,LTD
HFD1_k127_7365077_0	234267.Acid_0200	1.897e-285	897.0	COG3661@1|root,COG3661@2|Bacteria,3Y3Q5@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 67 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7377052_9	234267.Acid_5772	3.396e-06	49.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD1_k127_7377052_3	1267534.KB906755_gene3953	1.776e-36	149.0	2DIKN@1|root,32UB8@2|Bacteria,3Y8SQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7377052_8	1267534.KB906755_gene3954	1.875e-14	78.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	copZ	-	-	ko:K07213,ko:K08364	ko04978,map04978	-	-	-	ko00000,ko00001,ko02000	1.A.72.1	-	-	HMA
HFD1_k127_7377052_2	278963.ATWD01000001_gene3200	2.173e-48	184.0	2BZS5@1|root,2Z9YI@2|Bacteria,3Y6UF@57723|Acidobacteria,2JM0A@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7377052_0	234267.Acid_2471	6.239e-292	925.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	234267.Acid_2471|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD1_k127_7377052_1	861299.J421_6233	2.721e-56	200.0	2DKWS@1|root,30N64@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
HFD1_k127_7377052_5	396588.Tgr7_0622	1.219e-21	100.0	COG4096@1|root,COG4096@2|Bacteria	2|Bacteria	L	type I site-specific deoxyribonuclease activity	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF4145,EcoEI_R_C,HSDR_N,Helicase_C,ResIII
HFD1_k127_7377052_6	1123354.AUDR01000011_gene1494	1.387e-21	99.0	2E1B7@1|root,32WR3@2|Bacteria,1N4JM@1224|Proteobacteria,2VVF6@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7377052_4	887898.HMPREF0551_2071	3.313e-27	118.0	COG4190@1|root,COG4190@2|Bacteria,1N0FF@1224|Proteobacteria,2VUDR@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD1_k127_7380330_0	1340493.JNIF01000004_gene333	6.603e-173	554.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD1_k127_7380330_1	234267.Acid_2806	3.725e-138	445.0	COG1082@1|root,COG1082@2|Bacteria,3Y4EN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7380330_2	234267.Acid_2805	9.439e-90	304.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA synthetase, class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD1_k127_7383725_2	237368.SCABRO_02611	2.591e-10	72.0	COG0457@1|root,COG0457@2|Bacteria,2J306@203682|Planctomycetes	203682|Planctomycetes	KLT	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_8
HFD1_k127_7383725_0	234267.Acid_5952	4.029e-242	790.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_7383725_1	1340493.JNIF01000004_gene88	2.049e-69	252.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_7385608_0	234267.Acid_5952	3.615e-158	535.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_7385608_1	234267.Acid_7238	1.641e-36	139.0	COG1278@1|root,COG1278@2|Bacteria,3Y5GC@57723|Acidobacteria	57723|Acidobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD1_k127_7385608_2	234267.Acid_7239	5.953e-12	66.0	COG0361@1|root,COG0361@2|Bacteria,3Y8IP@57723|Acidobacteria	57723|Acidobacteria	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD1_k127_7399994_3	5061.CADANGAP00003172	1.113e-11	70.0	COG3616@1|root,2QRDB@2759|Eukaryota,39Y1S@33154|Opisthokonta,3PBSX@4751|Fungi,3R10E@4890|Ascomycota,20Q37@147545|Eurotiomycetes,3SAGR@5042|Eurotiales	4751|Fungi	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HFD1_k127_7399994_2	420324.KI912090_gene7079	5.311e-37	143.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria,1JUX9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_7399994_0	1123073.KB899242_gene1328	3.566e-72	254.0	COG3291@1|root,COG3291@2|Bacteria,1NSHN@1224|Proteobacteria	1224|Proteobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7399994_1	880070.Cycma_1900	9.971e-38	149.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	dhaa	-	4.1.2.42,4.1.3.41	ko:K18425,ko:K19967	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
HFD1_k127_7417952_3	589865.DaAHT2_1690	9.795e-32	141.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MJ3U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HFD1_k127_7417952_7	1236902.ANAS01000031_gene2881	9.92e-12	78.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4EJ30@85012|Streptosporangiales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
HFD1_k127_7417952_0	1267533.KB906733_gene3362	1.648e-108	372.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_7417952_6	234267.Acid_2463	1.212e-12	79.0	COG2133@1|root,COG2133@2|Bacteria,3Y81J@57723|Acidobacteria	57723|Acidobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_7417952_1	1217720.ALOX01000004_gene4052	1.848e-51	204.0	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_32265	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_7417952_2	525897.Dbac_2114	6.355e-37	153.0	COG0826@1|root,COG0826@2|Bacteria,1QMCE@1224|Proteobacteria,42PSK@68525|delta/epsilon subdivisions,2WKMU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
HFD1_k127_7417952_4	1121937.AUHJ01000006_gene2536	2.156e-21	105.0	COG5285@1|root,COG5285@2|Bacteria,1RK7S@1224|Proteobacteria,1SHAS@1236|Gammaproteobacteria,46BUA@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD1_k127_7419179_0	1079460.ATTQ01000051_gene6378	1.244e-73	263.0	COG2041@1|root,COG2041@2|Bacteria,1QT0I@1224|Proteobacteria,2V9JK@28211|Alphaproteobacteria,4BGN1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD1_k127_7419179_1	1123278.KB893579_gene883	1.441e-07	60.0	28JZQ@1|root,2Z9PN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7422815_0	234267.Acid_2370	2.227e-136	437.0	COG0687@1|root,COG0687@2|Bacteria,3Y5JD@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
HFD1_k127_7422815_3	118173.KB235914_gene4218	7.358e-23	111.0	COG0457@1|root,COG0457@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HFD1_k127_7422815_2	1449346.JQMO01000001_gene7043	1.963e-51	199.0	COG4257@1|root,COG4257@2|Bacteria,2GJU3@201174|Actinobacteria	201174|Actinobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF11
HFD1_k127_7422815_4	402777.KB235904_gene3390	1.368e-14	86.0	COG0689@1|root,COG2931@1|root,COG3391@1|root,COG4257@1|root,COG4932@1|root,COG5184@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4257@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1GBCU@1117|Cyanobacteria	1117|Cyanobacteria	DMQZ	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,HemolysinCabind
HFD1_k127_7422815_5	865937.Gilli_0789	1.196e-13	72.0	COG3420@1|root,COG4932@1|root,COG3420@2|Bacteria,COG4932@2|Bacteria,4PP4R@976|Bacteroidetes,1ICSM@117743|Flavobacteriia,2P78Q@244698|Gillisia	976|Bacteroidetes	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7422815_1	234267.Acid_2457	3.631e-60	211.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	HHH_8,PHP
HFD1_k127_7442716_2	1267535.KB906767_gene4135	1.301e-118	390.0	COG3336@1|root,COG3474@1|root,COG3336@2|Bacteria,COG3474@2|Bacteria,3Y6N7@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
HFD1_k127_7442716_7	234267.Acid_6903	6.078e-64	220.0	COG3193@1|root,COG3193@2|Bacteria,3Y4PS@57723|Acidobacteria	57723|Acidobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD1_k127_7442716_5	234267.Acid_4426	2.422e-76	270.0	COG0500@1|root,COG0500@2|Bacteria,3Y7QV@57723|Acidobacteria	2|Bacteria	Q	Methyltransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_11,Methyltransf_25,Methyltransf_31
HFD1_k127_7442716_1	234267.Acid_1515	1.442e-264	829.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7442716_0	234267.Acid_1514	2.47e-322	1011.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7442716_3	1340493.JNIF01000003_gene2775	2.532e-113	382.0	COG1216@1|root,COG1216@2|Bacteria,3Y9AS@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_7442716_8	1340493.JNIF01000003_gene2774	5.277e-48	181.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2,TPR_8
HFD1_k127_7442716_6	1340493.JNIF01000003_gene2748	1.392e-68	245.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene2748|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7442716_4	448385.sce7171	1.775e-100	334.0	COG1132@1|root,COG1132@2|Bacteria,1NRJ2@1224|Proteobacteria,437FW@68525|delta/epsilon subdivisions,2X2NG@28221|Deltaproteobacteria,2YTZX@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD1_k127_7460051_4	234267.Acid_5908	1.761e-98	340.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CHASE,DUF3365,GAF_2,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
HFD1_k127_7460051_10	448385.sce1953	1.911e-21	110.0	COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,42S9Y@68525|delta/epsilon subdivisions,2WNFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_7460051_5	234267.Acid_2174	7.951e-61	225.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Calx-beta,F5_F8_type_C,PA14,RicinB_lectin_2,Ricin_B_lectin,SdrD_B
HFD1_k127_7460051_2	234267.Acid_1154	5.66e-118	414.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_7460051_6	234267.Acid_7677	4.001e-53	193.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_7460051_7	1047013.AQSP01000099_gene1507	2.433e-52	201.0	COG3016@1|root,COG3016@2|Bacteria,2NRWX@2323|unclassified Bacteria	2|Bacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
HFD1_k127_7460051_0	1379698.RBG1_1C00001G0607	3.592e-174	573.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HFD1_k127_7460051_3	1123073.KB899243_gene711	8.612e-112	401.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X52Q@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_10,TPR_12
HFD1_k127_7460051_1	234267.Acid_1154	3.709e-135	465.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_7460051_8	1137268.AZXF01000039_gene975	4.831e-31	124.0	COG3911@1|root,COG3911@2|Bacteria,2ICX8@201174|Actinobacteria	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
HFD1_k127_7460570_2	234267.Acid_0398	3.079e-102	338.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
HFD1_k127_7460570_0	234267.Acid_0399	4.846e-219	685.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	2|Bacteria	C	Polysulphide reductase, NrfD	qrcD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD1_k127_7460570_1	234267.Acid_0400	1.579e-102	343.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
HFD1_k127_7460570_3	234267.Acid_0401	2.732e-48	186.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding,Peptidase_S8
HFD1_k127_7473223_6	234267.Acid_4207	4.125e-158	501.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_7473223_3	234267.Acid_4206	3.355e-216	683.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD1_k127_7473223_5	234267.Acid_4205	2.322e-203	644.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD1_k127_7473223_7	234267.Acid_4204	2.557e-141	450.0	COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD1_k127_7473223_9	234267.Acid_4203	4.408e-107	351.0	COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria	57723|Acidobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
HFD1_k127_7473223_13	234267.Acid_3866	5.706e-52	192.0	COG1794@1|root,COG1794@2|Bacteria,3Y5EC@57723|Acidobacteria	57723|Acidobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HFD1_k127_7473223_12	1382359.JIAL01000001_gene658	7.395e-58	204.0	COG1733@1|root,COG1733@2|Bacteria,3Y7XV@57723|Acidobacteria,2JN1Y@204432|Acidobacteriia	204432|Acidobacteriia	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD1_k127_7473223_2	1267535.KB906767_gene3396	1.149e-220	694.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD1_k127_7473223_15	497964.CfE428DRAFT_3867	2.491e-31	131.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
HFD1_k127_7473223_16	1123228.AUIH01000091_gene567	1.394e-22	100.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria,1XMEE@135619|Oceanospirillales	135619|Oceanospirillales	S	Cytotoxic translational repressor of toxin-antitoxin stability system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
HFD1_k127_7473223_17	234267.Acid_7918	1.467e-11	69.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,MqsA_antitoxin
HFD1_k127_7473223_1	234267.Acid_7406	0.0	1025.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
HFD1_k127_7473223_10	234267.Acid_6227	7.748e-75	265.0	COG1898@1|root,COG1898@2|Bacteria,3Y5V0@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD1_k127_7473223_8	234267.Acid_6226	3.209e-130	445.0	COG1209@1|root,COG1209@2|Bacteria,3Y2ZJ@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD1_k127_7473223_14	234267.Acid_6341	9.261e-47	171.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_7473223_4	234267.Acid_2295	4.466e-207	664.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD1_k127_7473223_11	204669.Acid345_4507	1.835e-70	247.0	COG3324@1|root,COG3324@2|Bacteria,3Y5KZ@57723|Acidobacteria,2JJVT@204432|Acidobacteriia	204432|Acidobacteriia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_7473223_0	234267.Acid_7252	0.0	1136.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD1_k127_7474023_6	1123503.KB908056_gene2123	1.004e-36	143.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD1_k127_7474023_1	251221.35211765	4.037e-169	559.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_7474023_9	1449976.KALB_6245	0.0001568	48.0	COG0657@1|root,COG0657@2|Bacteria,2I5U9@201174|Actinobacteria,4E25X@85010|Pseudonocardiales	201174|Actinobacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD1_k127_7474023_3	234267.Acid_3068	3.855e-119	395.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	yieL	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_7474023_7	760192.Halhy_6457	3.593e-08	61.0	COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,1IXM3@117747|Sphingobacteriia	976|Bacteroidetes	P	PFAM Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD1_k127_7474023_2	234267.Acid_2087	1.022e-135	438.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	DUF1080,LRR_5
HFD1_k127_7474023_8	234267.Acid_4266	3.448e-05	53.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_7474023_5	1185876.BN8_05295	5.969e-43	166.0	COG0684@1|root,COG0684@2|Bacteria,4NHRR@976|Bacteroidetes,47KQ5@768503|Cytophagia	976|Bacteroidetes	H	Pfam:Methyltransf_6	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HFD1_k127_7474023_4	1121904.ARBP01000001_gene5968	3.274e-90	301.0	COG0800@1|root,COG0800@2|Bacteria,4NEFY@976|Bacteroidetes,47PM4@768503|Cytophagia	976|Bacteroidetes	G	PFAM KDPG and KHG aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD1_k127_7474023_0	234267.Acid_7944	5.487e-195	620.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7479899_0	926550.CLDAP_13780	6.446e-74	263.0	COG2311@1|root,COG2311@2|Bacteria,2G8B7@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
HFD1_k127_7479899_1	234267.Acid_2034	2.205e-61	222.0	COG0484@1|root,COG0484@2|Bacteria,3Y8AR@57723|Acidobacteria	57723|Acidobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD1_k127_7479899_2	886293.Sinac_7308	9.347e-58	213.0	COG1082@1|root,COG1082@2|Bacteria,2J0SX@203682|Planctomycetes	203682|Planctomycetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7479899_3	234267.Acid_7338	4.178e-50	179.0	COG1228@1|root,COG1228@2|Bacteria,3Y39J@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_7505455_3	344747.PM8797T_17212	1.685e-11	72.0	COG1649@1|root,COG1649@2|Bacteria,2IX7D@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
HFD1_k127_7505455_2	468059.AUHA01000002_gene531	1.376e-75	273.0	29Z06@1|root,30KX7@2|Bacteria,4NZNI@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HFD1_k127_7505455_0	379066.GAU_3197	1.209e-233	743.0	COG0521@1|root,COG0521@2|Bacteria,1ZSSR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Susd and RagB outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	SusD-like_2
HFD1_k127_7505455_1	468059.AUHA01000002_gene533	1.487e-178	565.0	COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1IPAN@117747|Sphingobacteriia	976|Bacteroidetes	P	TonB-linked outer membrane protein, SusC RagA family	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
HFD1_k127_7510886_1	1210884.HG799467_gene13397	4.425e-34	134.0	COG3677@1|root,COG3677@2|Bacteria,2J259@203682|Planctomycetes	203682|Planctomycetes	KL	Transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	-
HFD1_k127_7510886_0	1210884.HG799465_gene11367	1.192e-37	151.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
HFD1_k127_7518678_1	68223.JNZY01000005_gene3915	7.272e-18	87.0	COG0726@1|root,COG0726@2|Bacteria,2IBGP@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7518678_0	713587.THITH_09765	2.382e-33	148.0	COG3055@1|root,COG5640@1|root,COG3055@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,PPC,Trypsin
HFD1_k127_7518678_2	1961.JOAK01000003_gene1705	1.762e-10	74.0	COG0726@1|root,COG0726@2|Bacteria,2I3D0@201174|Actinobacteria	201174|Actinobacteria	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
HFD1_k127_7533750_5	69395.JQLZ01000001_gene3018	1.247e-100	338.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD1_k127_7533750_3	1396418.BATQ01000035_gene5726	2.899e-111	383.0	COG1506@1|root,COG1506@2|Bacteria,46UJP@74201|Verrucomicrobia,2IVGS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7533750_4	1267535.KB906767_gene455	6.113e-103	359.0	COG0657@1|root,COG0657@2|Bacteria,3Y62J@57723|Acidobacteria,2JM4E@204432|Acidobacteriia	204432|Acidobacteriia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD1_k127_7533750_1	234267.Acid_2924	1.63e-161	516.0	COG2461@1|root,COG2461@2|Bacteria,3Y7BF@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
HFD1_k127_7533750_6	521674.Plim_2786	2.234e-52	193.0	COG4185@1|root,COG4185@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Zeta_toxin
HFD1_k127_7533750_2	234267.Acid_1315	3.594e-126	406.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_7533750_0	234267.Acid_1317	0.0	1110.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,F5_F8_type_C,Lactonase,Phosphoesterase
HFD1_k127_7535430_5	234267.Acid_7064	2.299e-21	96.0	COG5450@1|root,COG5450@2|Bacteria,3Y608@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HFD1_k127_7535430_1	234267.Acid_1046	4.837e-143	457.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_7535430_3	1123276.KB893270_gene4700	3.585e-61	218.0	COG3403@1|root,COG3403@2|Bacteria,4NHNG@976|Bacteroidetes,47QX1@768503|Cytophagia	976|Bacteroidetes	S	YqcI/YcgG family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7535430_0	234267.Acid_4612	3.277e-215	677.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_7535430_6	583355.Caka_0136	3.235e-05	55.0	2CDPD@1|root,2ZGI1@2|Bacteria	583355.Caka_0136|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7535430_4	713587.THITH_07380	5.926e-23	114.0	COG0457@1|root,COG0457@2|Bacteria	713587.THITH_07380|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7535430_2	335543.Sfum_0219	5.952e-120	392.0	COG0457@1|root,COG3118@1|root,COG3379@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42XTF@68525|delta/epsilon subdivisions,2WSZG@28221|Deltaproteobacteria,2MRX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD1_k127_7560909_4	511.JT27_05830	4.535e-14	75.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria,3T3GY@506|Alcaligenaceae	28216|Betaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HFD1_k127_7560909_0	365046.Rta_03320	2.429e-121	396.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,4A9J7@80864|Comamonadaceae	28216|Betaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD1_k127_7560909_1	762966.HMPREF9439_01950	3.042e-52	187.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,4PR5Z@995019|Sutterellaceae	28216|Betaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD1_k127_7560909_2	762966.HMPREF9439_01949	5.402e-49	175.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,4PR4Y@995019|Sutterellaceae	28216|Betaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD1_k127_7560909_3	1007105.PT7_2892	7.358e-36	136.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,3T1RW@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD1_k127_7566454_10	1173028.ANKO01000056_gene2206	3.493e-48	182.0	COG1118@1|root,COG4149@1|root,COG1118@2|Bacteria,COG4149@2|Bacteria,1G08P@1117|Cyanobacteria,1H9CG@1150|Oscillatoriales	1117|Cyanobacteria	P	molybdate ABC transporter, permease protein	modB	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1
HFD1_k127_7566454_9	1121428.DESHY_60383___1	6.631e-54	206.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,260PS@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iHN637.CLJU_RS12820	SBP_bac_11
HFD1_k127_7566454_8	234267.Acid_4043	1.208e-63	225.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7566454_4	344747.PM8797T_14594	1.678e-142	466.0	COG3119@1|root,COG3119@2|Bacteria,2IYRK@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_7566454_1	234267.Acid_2661	3.111e-220	688.0	COG4948@1|root,COG4948@2|Bacteria,3Y2UE@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_7566454_12	1340493.JNIF01000003_gene1485	5.108e-41	170.0	COG2080@1|root,COG2080@2|Bacteria,3Y4U1@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S -binding domain protein	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_7566454_0	1047013.AQSP01000139_gene2342	2.393e-231	736.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD1_k127_7566454_17	1136417.AZWE01000012_gene2542	1.465e-13	79.0	COG1183@1|root,COG1183@2|Bacteria,2I3MV@201174|Actinobacteria,4DA88@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
HFD1_k127_7566454_18	1123372.AUIT01000005_gene1264	9.073e-08	61.0	COG0558@1|root,COG0558@2|Bacteria,2GHS4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HFD1_k127_7566454_11	1051632.TPY_3118	3.521e-46	182.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD1_k127_7566454_3	573413.Spirs_1245	2.105e-166	538.0	COG0535@1|root,COG0535@2|Bacteria,2J83E@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HFD1_k127_7566454_15	234267.Acid_3570	4.457e-20	101.0	COG2246@1|root,COG2246@2|Bacteria,3Y5HC@57723|Acidobacteria	57723|Acidobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HFD1_k127_7566454_16	1125701.HMPREF1221_01616	3.035e-19	102.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7566454_5	234267.Acid_7683	2.701e-123	419.0	COG3622@1|root,COG3622@2|Bacteria,3Y72X@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_7566454_2	234267.Acid_7682	8.45e-188	594.0	COG2133@1|root,COG2133@2|Bacteria,3Y6W0@57723|Acidobacteria	57723|Acidobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
HFD1_k127_7566454_13	234267.Acid_3539	2.346e-38	156.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD1_k127_7566454_6	234267.Acid_5838	3.417e-73	252.0	COG2606@1|root,COG2606@2|Bacteria,3Y54I@57723|Acidobacteria	57723|Acidobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD1_k127_7566454_7	234267.Acid_7266	4.25e-67	242.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD1_k127_7566454_19	234267.Acid_0770	4.655e-06	57.0	2F1JK@1|root,33UK0@2|Bacteria,3Y7KY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7566454_20	909663.KI867150_gene2770	2.656e-05	46.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HFD1_k127_7570156_3	861299.J421_0552	6.026e-32	131.0	2DMJE@1|root,32RYR@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HFD1_k127_7570156_2	483219.LILAB_31685	2.628e-60	232.0	COG3193@1|root,COG3193@2|Bacteria,1QX6Y@1224|Proteobacteria,43BZP@68525|delta/epsilon subdivisions,2X7AG@28221|Deltaproteobacteria,2YU0D@29|Myxococcales	28221|Deltaproteobacteria	S	SusD family	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD_RagB
HFD1_k127_7570156_0	483219.LILAB_31680	4.365e-206	688.0	COG4206@1|root,COG4206@2|Bacteria,1QXUW@1224|Proteobacteria,43C7J@68525|delta/epsilon subdivisions,2X7HV@28221|Deltaproteobacteria,2YU5W@29|Myxococcales	28221|Deltaproteobacteria	H	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
HFD1_k127_7570156_1	1278073.MYSTI_04407	6.879e-109	359.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD1_k127_7579323_7	1267535.KB906767_gene1964	2.987e-88	299.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
HFD1_k127_7579323_2	234267.Acid_7597	1.982e-189	605.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	bgaB	-	3.2.1.23	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_14,Glyco_hydro_42,Glyco_hydro_42M
HFD1_k127_7579323_10	234267.Acid_7597	1.624e-77	270.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	bgaB	-	3.2.1.23	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_14,Glyco_hydro_42,Glyco_hydro_42M
HFD1_k127_7579323_3	1267533.KB906733_gene3159	6.739e-151	493.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	nagH	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Cyc-maltodext_C,F5_F8_type_C,GHL6,Glyco_hydro_20,Glyco_hydro_20b,Glyco_hydro_42M,Gram_pos_anchor,NAGidase,YSIRK_signal
HFD1_k127_7579323_5	1267533.KB906733_gene3159	3.322e-127	418.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	nagH	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Cyc-maltodext_C,F5_F8_type_C,GHL6,Glyco_hydro_20,Glyco_hydro_20b,Glyco_hydro_42M,Gram_pos_anchor,NAGidase,YSIRK_signal
HFD1_k127_7579323_0	234267.Acid_7602	9.621e-214	673.0	COG2133@1|root,COG2133@2|Bacteria,3Y407@57723|Acidobacteria	57723|Acidobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_7579323_20	1396141.BATP01000020_gene85	6.874e-08	60.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_7579323_6	234267.Acid_4058	7.411e-116	380.0	COG1649@1|root,COG1649@2|Bacteria,3Y2XT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7579323_17	234267.Acid_1623	9.16e-40	150.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
HFD1_k127_7579323_1	742727.HMPREF9447_05024	3.27e-204	665.0	COG3250@1|root,COG5492@1|root,COG3250@2|Bacteria,COG5492@2|Bacteria,4PKXA@976|Bacteroidetes,2FP7W@200643|Bacteroidia,4AN8Z@815|Bacteroidaceae	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,Lyase_8,Lyase_8_C,Lyase_8_N
HFD1_k127_7579323_16	452637.Oter_3515	5.451e-40	164.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia,3K9I6@414999|Opitutae	414999|Opitutae	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_7579323_14	1396141.BATP01000002_gene4837	6.427e-49	192.0	COG3828@1|root,COG3828@2|Bacteria,46V1D@74201|Verrucomicrobia,2IUS0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HFD1_k127_7579323_9	1185876.BN8_04770	6.961e-78	276.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_7579323_18	1123242.JH636434_gene5340	8.4e-38	163.0	COG1413@1|root,COG1413@2|Bacteria,2IZE1@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_7579323_13	314230.DSM3645_14090	5.516e-51	199.0	COG1413@1|root,COG3828@1|root,COG1413@2|Bacteria,COG3828@2|Bacteria,2IX8S@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_7579323_4	240016.ABIZ01000001_gene3841	5.73e-128	421.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_7579323_19	1340493.JNIF01000003_gene1556	2.24e-09	70.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT,HEAT_2
HFD1_k127_7579323_12	314230.DSM3645_14090	7.026e-54	213.0	COG1413@1|root,COG3828@1|root,COG1413@2|Bacteria,COG3828@2|Bacteria,2IX8S@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_7579323_11	452637.Oter_3514	5.72e-65	230.0	2F286@1|root,33V6C@2|Bacteria,46V8R@74201|Verrucomicrobia,3K9H5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7579323_8	234267.Acid_1943	7.712e-83	284.0	COG1082@1|root,COG1082@2|Bacteria,3Y71Y@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_7579323_15	1267535.KB906767_gene4393	1.446e-41	156.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_7586384_1	945713.IALB_1080	3.669e-183	584.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_7586384_0	945713.IALB_1079	7.765e-256	800.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HFD1_k127_7586384_2	977880.RALTA_A0163	6.368e-133	446.0	COG1404@1|root,COG1404@2|Bacteria,1R5Y1@1224|Proteobacteria,2VS1E@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD1_k127_7586384_5	69395.JQLZ01000004_gene535	1.934e-72	260.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2U7SC@28211|Alphaproteobacteria,2KIMB@204458|Caulobacterales	204458|Caulobacterales	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7586384_3	1267534.KB906756_gene400	2.522e-112	374.0	COG3673@1|root,COG3673@2|Bacteria,3Y30E@57723|Acidobacteria,2JIPR@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
HFD1_k127_7586384_4	1340493.JNIF01000003_gene3568	4.546e-82	282.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_7586384_6	1340493.JNIF01000004_gene32	1.41e-66	229.0	COG2355@1|root,COG2355@2|Bacteria,3Y7FK@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_7607741_4	926560.KE387023_gene3341	9.11e-45	168.0	COG2124@1|root,COG2124@2|Bacteria,1WIX6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	cytochrome P450	-	-	1.14.15.24	ko:K22492	ko00906,map00906	-	R07558,R07559,R09747	RC00478,RC02629	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
HFD1_k127_7607741_5	118173.KB235914_gene1566	1.9e-27	125.0	28UM7@1|root,2ZGRR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7607741_6	596153.Alide_4612	3.595e-10	71.0	COG3381@1|root,COG3381@2|Bacteria,1RAXF@1224|Proteobacteria,2VY6I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HFD1_k127_7607741_7	272569.rrnAC1203	3.015e-08	66.0	arCOG04198@1|root,arCOG04198@2157|Archaea,2XU58@28890|Euryarchaeota,23UGH@183963|Halobacteria	183963|Halobacteria	Q	TIGRFAM DMSO reductase family type II enzyme, heme b subunit	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
HFD1_k127_7607741_2	1238190.AMQY01000010_gene2332	1.18e-119	394.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria,1XNNX@135619|Oceanospirillales	135619|Oceanospirillales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD1_k127_7607741_0	1324957.K933_02681	2.885e-281	894.0	COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria	183963|Halobacteria	C	Nitrate reductase alpha subunit	narG	-	-	ko:K17050	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Molybdopterin,Molydop_binding
HFD1_k127_7607741_8	269799.Gmet_1088	1.358e-05	59.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HFD1_k127_7607741_3	316067.Geob_0122	7.048e-45	187.0	COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria,43U4I@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD1_k127_7607741_1	1125863.JAFN01000001_gene2794	1.31e-163	523.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD1_k127_7614364_0	1340493.JNIF01000003_gene4672	7.583e-196	618.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7614364_4	272134.KB731324_gene4699	4.25e-28	128.0	COG1785@1|root,COG1785@2|Bacteria	2|Bacteria	P	alkaline phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Alk_phosphatase,Big_5,ChW,DUF4347,VCBS
HFD1_k127_7614364_3	63737.Npun_F1213	1.936e-30	135.0	COG1100@1|root,COG4886@1|root,COG1100@2|Bacteria,COG4886@2|Bacteria,1G05B@1117|Cyanobacteria,1HK2M@1161|Nostocales	1117|Cyanobacteria	S	C-terminal of Roc, COR, domain	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	COR,LRR_1,LRR_4,LRR_8,LRR_9,Roc
HFD1_k127_7614364_2	1379270.AUXF01000001_gene1899	2.128e-93	320.0	COG0251@1|root,COG3391@1|root,COG0251@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	tdcF	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP,VCBS
HFD1_k127_7614364_1	234267.Acid_3215	1.967e-174	552.0	COG2382@1|root,COG2382@2|Bacteria,3Y5EH@57723|Acidobacteria	57723|Acidobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD1_k127_7636805_0	234267.Acid_3066	1.995e-213	707.0	COG1629@1|root,COG4771@2|Bacteria,3Y6ZH@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_7636805_1	1267535.KB906767_gene3369	1.039e-186	595.0	COG0673@1|root,COG0673@2|Bacteria,3Y79F@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_7636805_4	713586.KB900536_gene2395	1.597e-141	456.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HFD1_k127_7636805_5	234267.Acid_6487	5.306e-137	450.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD1_k127_7636805_3	1340493.JNIF01000003_gene4574	1.667e-172	565.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD1_k127_7636805_2	1340493.JNIF01000003_gene4575	1.905e-180	585.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_7643396_3	234267.Acid_1254	9.202e-108	351.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria	57723|Acidobacteria	I	Myo-inositol-1-phosphate synthase, GAPDH domain protein	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HFD1_k127_7643396_2	234267.Acid_1253	1.684e-135	435.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HFD1_k127_7643396_4	234267.Acid_5759	7.795e-85	298.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	rhgT	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_GDSL_2,Pectinesterase
HFD1_k127_7643396_1	1123234.AUKI01000011_gene1462	2.575e-159	524.0	2DBT8@1|root,2ZAWK@2|Bacteria,4NK5N@976|Bacteroidetes,1I0UW@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7643396_6	1227739.Hsw_3440	3.06e-62	231.0	COG3647@1|root,COG3647@2|Bacteria,4NMNV@976|Bacteroidetes,47RI0@768503|Cytophagia	976|Bacteroidetes	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HFD1_k127_7643396_8	234267.Acid_3138	2.354e-05	48.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD1_k127_7643396_0	234267.Acid_1201	0.0	1227.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HFD1_k127_7643396_7	246969.TAM4_499	1.646e-10	71.0	COG0515@1|root,arCOG00372@1|root,arCOG03264@1|root,arCOG00372@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2XWYZ@28890|Euryarchaeota,2437Z@183968|Thermococci	183968|Thermococci	T	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD1_k127_7650163_0	314230.DSM3645_18961	1.563e-156	527.0	COG0577@1|root,COG0577@2|Bacteria,2IYHP@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7650163_4	314230.DSM3645_24005	3.51e-93	320.0	COG1520@1|root,COG1520@2|Bacteria,2IYEA@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_7650163_2	1123242.JH636435_gene2360	2.727e-129	436.0	COG1520@1|root,COG1520@2|Bacteria,2IXST@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_7650163_7	1123242.JH636435_gene1405	1.416e-83	291.0	COG1520@1|root,COG1520@2|Bacteria,2IYZY@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_7650163_1	344747.PM8797T_21598	1.251e-138	455.0	COG1520@1|root,COG1520@2|Bacteria,2IXCF@203682|Planctomycetes	203682|Planctomycetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_7650163_5	1403819.BATR01000089_gene2616	1.266e-91	334.0	COG1520@1|root,COG1520@2|Bacteria,46TSY@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD1_k127_7650163_3	1210884.HG799469_gene14163	1.607e-113	381.0	COG0666@1|root,COG1520@1|root,COG0666@2|Bacteria,COG1520@2|Bacteria,2J2A4@203682|Planctomycetes	203682|Planctomycetes	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_7650163_6	1168034.FH5T_01575	1.953e-87	303.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
HFD1_k127_7650163_10	1121448.DGI_0529	3.508e-16	89.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_7650163_9	595460.RRSWK_06186	5.808e-27	124.0	2DVMZ@1|root,33WFQ@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
HFD1_k127_7650163_8	1168034.FH5T_01555	8.259e-72	254.0	COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia	976|Bacteroidetes	C	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
HFD1_k127_7654834_0	234267.Acid_3137	9.746e-74	261.0	COG4219@1|root,COG4219@2|Bacteria,3Y35Z@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_7654834_2	1174684.EBMC1_11830	6.733e-10	72.0	COG1555@1|root,COG1555@2|Bacteria,1NW2I@1224|Proteobacteria	1224|Proteobacteria	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7654834_1	1267533.KB906740_gene161	8.027e-11	65.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,DUF3298,DUF4163,Glyco_hydro_9,Polysacc_deac_1
HFD1_k127_7678232_6	1336208.JADY01000034_gene2358	6.705e-27	113.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,2JRF4@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_7678232_1	936455.KI421499_gene1157	1.263e-200	637.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,3JQVH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_07830	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8
HFD1_k127_7678232_9	234267.Acid_4101	1.315e-05	51.0	COG0577@1|root,COG0577@2|Bacteria,3Y6CK@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD1_k127_7678232_8	536227.CcarbDRAFT_0601	1.182e-21	103.0	COG0793@1|root,COG0793@2|Bacteria,1UYV5@1239|Firmicutes,24B0A@186801|Clostridia,36DRS@31979|Clostridiaceae	186801|Clostridia	M	Peptidase, S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD1_k127_7678232_2	234267.Acid_2740	5.071e-152	494.0	29UCR@1|root,30FP6@2|Bacteria,3Y4J8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7678232_4	234267.Acid_0027	1.038e-113	397.0	COG1082@1|root,COG1082@2|Bacteria,3Y6EB@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
HFD1_k127_7678232_0	234267.Acid_5495	2.528e-207	651.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	1.13.12.3	ko:K00466	ko00380,map00380	-	R00679	RC00213	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_7678232_5	1267533.KB906737_gene1877	1.12e-66	237.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD1_k127_770683_19	234267.Acid_2220	2.829e-33	130.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD1_k127_770683_16	234267.Acid_2221	8.332e-61	219.0	COG1989@1|root,COG1989@2|Bacteria,3Y9FS@57723|Acidobacteria	57723|Acidobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HFD1_k127_770683_6	234267.Acid_3244	7.464e-134	441.0	COG2133@1|root,COG2133@2|Bacteria,3Y7A7@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_770683_10	234267.Acid_5566	1.05e-114	374.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_18	204669.Acid345_1284	6.428e-43	160.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_770683_4	452637.Oter_1855	2.181e-167	558.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_770683_1	234267.Acid_1765	1.334e-315	989.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_1765|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_20	861299.J421_2271	3.938e-14	76.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_770683_7	204669.Acid345_4155	5.503e-133	459.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HFD1_k127_770683_17	1340493.JNIF01000003_gene1682	1.001e-60	239.0	COG0515@1|root,COG0515@2|Bacteria	1340493.JNIF01000003_gene1682|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_14	1340493.JNIF01000003_gene2146	7.197e-70	245.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD1_k127_770683_12	1340493.JNIF01000003_gene1390	4.414e-101	339.0	COG2010@1|root,COG2010@2|Bacteria,3Y5ZT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD1_k127_770683_3	1267535.KB906767_gene4724	4.301e-191	610.0	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4724|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_8	1267535.KB906767_gene4724	2.354e-125	428.0	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4724|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_13	794903.OPIT5_07145	3.793e-72	259.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS,STAS_2
HFD1_k127_770683_11	794903.OPIT5_07150	1.478e-103	357.0	COG4120@1|root,COG4120@2|Bacteria,46YK2@74201|Verrucomicrobia,3K9RK@414999|Opitutae	414999|Opitutae	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
HFD1_k127_770683_9	794903.OPIT5_07155	1.911e-116	380.0	COG1101@1|root,COG1101@2|Bacteria,46YSY@74201|Verrucomicrobia,3K9UK@414999|Opitutae	414999|Opitutae	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HFD1_k127_770683_15	521674.Plim_2859	1.052e-63	232.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	ABC-SBP	-	-	ko:K01989,ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD1_k127_770683_5	234267.Acid_4275	3.222e-150	501.0	COG1073@1|root,COG1073@2|Bacteria,3Y652@57723|Acidobacteria	57723|Acidobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_770683_2	234267.Acid_2550	2.104e-226	707.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
HFD1_k127_770683_0	234267.Acid_5844	0.0	1426.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HFD1_k127_7747752_8	1237149.C900_05306	2.926e-15	81.0	COG2067@1|root,COG2067@2|Bacteria,4NJB3@976|Bacteroidetes,47JGU@768503|Cytophagia	976|Bacteroidetes	I	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HFD1_k127_7747752_0	1267535.KB906767_gene1122	0.0	1066.0	COG0577@1|root,COG0577@2|Bacteria,3Y3YE@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7747752_5	1267535.KB906767_gene1121	3.489e-45	165.0	COG1695@1|root,COG1695@2|Bacteria,3Y882@57723|Acidobacteria	57723|Acidobacteria	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_7747752_2	272134.KB731325_gene694	1.028e-173	554.0	COG4941@1|root,COG4941@2|Bacteria,1G1YQ@1117|Cyanobacteria,1H7AG@1150|Oscillatoriales	1117|Cyanobacteria	K	RNA polymerase, sigma subunit, ECF family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7747752_4	1123508.JH636439_gene968	1.096e-49	179.0	COG3795@1|root,COG3795@2|Bacteria,2IZVT@203682|Planctomycetes	203682|Planctomycetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_7747752_3	1005048.CFU_3316	1.36e-54	216.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VSH3@28216|Betaproteobacteria,478SV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_7747752_7	448385.sce4729	2.529e-41	162.0	COG3795@1|root,COG3795@2|Bacteria,1RKYW@1224|Proteobacteria,43DU4@68525|delta/epsilon subdivisions,2WYVK@28221|Deltaproteobacteria,2Z0QY@29|Myxococcales	28221|Deltaproteobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
HFD1_k127_7747752_6	1340493.JNIF01000003_gene2247	8.059e-44	171.0	COG2764@1|root,COG2764@2|Bacteria,3Y5JW@57723|Acidobacteria	57723|Acidobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HFD1_k127_7747752_9	1267533.KB906734_gene4065	9.274e-15	84.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HFD1_k127_7747752_1	234267.Acid_4459	9.468e-179	566.0	COG0079@1|root,COG0079@2|Bacteria,3Y3Q8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_7754612_8	234267.Acid_4568	2.266e-46	173.0	COG2823@1|root,COG2823@2|Bacteria,3Y8WE@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HFD1_k127_7754612_9	93220.LV28_01610	5.159e-46	169.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2VT3J@28216|Betaproteobacteria,1K7KH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HFD1_k127_7754612_11	1232410.KI421421_gene3351	2.73e-10	67.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,42XTD@68525|delta/epsilon subdivisions,2WT90@28221|Deltaproteobacteria,43VVU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HFD1_k127_7754612_10	525897.Dbac_2186	3.501e-19	89.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7754612_6	234267.Acid_5949	1.131e-63	224.0	COG0817@1|root,COG0817@2|Bacteria,3Y5FH@57723|Acidobacteria	57723|Acidobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD1_k127_7754612_1	234267.Acid_5948	1.529e-135	434.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD1_k127_7754612_4	234267.Acid_1313	7.183e-81	290.0	COG1361@1|root,COG1361@2|Bacteria,3Y8BF@57723|Acidobacteria	57723|Acidobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7754612_7	234267.Acid_1312	6.212e-48	179.0	292F3@1|root,2ZPZC@2|Bacteria,3Y90G@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7754612_3	234267.Acid_1311	3.491e-112	366.0	COG0631@1|root,COG0631@2|Bacteria,3Y7SC@57723|Acidobacteria	57723|Acidobacteria	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD1_k127_7754612_0	234267.Acid_1310	2.212e-146	467.0	COG0382@1|root,COG0382@2|Bacteria,3Y3CW@57723|Acidobacteria	57723|Acidobacteria	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD1_k127_7754612_2	234267.Acid_1309	6.19e-116	375.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HFD1_k127_7781376_0	234267.Acid_6160	5.379e-50	183.0	COG2340@1|root,COG4733@1|root,COG2340@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta_helix,CAP,PKD,fn3
HFD1_k127_7781376_4	933262.AXAM01000172_gene934	1.198e-19	92.0	COG2337@1|root,COG2337@2|Bacteria,1N1DE@1224|Proteobacteria,42WAI@68525|delta/epsilon subdivisions,2WRAJ@28221|Deltaproteobacteria,2MNJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD1_k127_7781376_3	1382359.JIAL01000001_gene2115	2.445e-20	95.0	COG0668@1|root,COG0668@2|Bacteria,3Y2HH@57723|Acidobacteria,2JJZ5@204432|Acidobacteriia	204432|Acidobacteriia	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD1_k127_7782002_0	1210884.HG799467_gene13397	9.282e-44	167.0	COG3677@1|root,COG3677@2|Bacteria,2J259@203682|Planctomycetes	203682|Planctomycetes	KL	Transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	-
HFD1_k127_7782002_1	1210884.HG799465_gene11367	2.421e-34	145.0	COG1662@1|root,COG1662@2|Bacteria	2|Bacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
HFD1_k127_7810794_2	172088.AUGA01000007_gene8332	1.12e-155	504.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD1_k127_7810794_6	234267.Acid_5172	4.093e-111	365.0	COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria	57723|Acidobacteria	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD1_k127_7810794_8	234267.Acid_5171	2.235e-102	340.0	COG0438@1|root,COG0438@2|Bacteria,3Y7XP@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_7810794_4	234267.Acid_5170	2.513e-128	414.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	lgtF	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glycos_transf_2
HFD1_k127_7810794_3	234267.Acid_5169	8.4e-149	479.0	COG1994@1|root,COG1994@2|Bacteria,3Y4IT@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7810794_11	234267.Acid_5168	1.868e-57	201.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_7810794_10	234267.Acid_5167	3.818e-60	218.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FCD,Flavin_Reduct
HFD1_k127_7810794_0	234267.Acid_5166	2.774e-224	707.0	COG0156@1|root,COG0156@2|Bacteria,3Y3J2@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_7810794_12	471854.Dfer_4778	7.945e-54	195.0	COG4636@1|root,COG4636@2|Bacteria,4NQ9M@976|Bacteroidetes,47QMK@768503|Cytophagia	976|Bacteroidetes	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD1_k127_7810794_7	234267.Acid_1866	1.562e-104	351.0	COG1082@1|root,COG1082@2|Bacteria,3Y70I@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7810794_1	234267.Acid_6533	1.172e-172	554.0	COG3258@1|root,COG3258@2|Bacteria,3Y8BC@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7810794_9	234267.Acid_6532	1.215e-82	288.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7810794_13	234267.Acid_1238	9.71e-42	167.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_7810794_5	234267.Acid_4768	1.791e-116	385.0	COG0510@1|root,COG0510@2|Bacteria,3Y88W@57723|Acidobacteria	57723|Acidobacteria	M	Choline/ethanolamine kinase	-	-	-	ko:K09965	-	-	-	-	ko00000	-	-	-	APH
HFD1_k127_7810794_14	1211815.CBYP010000042_gene2351	1.516e-41	156.0	COG2021@1|root,COG2021@2|Bacteria,2I3NA@201174|Actinobacteria,4EXFB@85013|Frankiales	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HFD1_k127_7818784_8	717606.PaecuDRAFT_1608	5.642e-14	75.0	COG3852@1|root,COG3852@2|Bacteria,1TRYS@1239|Firmicutes,4ISNV@91061|Bacilli,2775B@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_7818784_4	1125863.JAFN01000001_gene2253	7.98e-113	383.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_7818784_0	1340493.JNIF01000004_gene564	0.0	1289.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD1_k127_7818784_7	1340493.JNIF01000003_gene4190	2.963e-35	140.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20,HTH_5
HFD1_k127_7818784_5	1340493.JNIF01000003_gene4191	6.597e-97	329.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_7818784_1	234267.Acid_3712	3.297e-300	936.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7818784_3	234267.Acid_1807	1.691e-167	532.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Thioredoxin_7
HFD1_k127_7818784_2	204669.Acid345_2300	3.719e-179	588.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria,2JMJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HFD1_k127_7818784_6	234267.Acid_4469	1.234e-87	295.0	COG2227@1|root,COG2227@2|Bacteria,3Y2SJ@57723|Acidobacteria	57723|Acidobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_7819063_1	234267.Acid_3902	4.379e-19	87.0	COG0673@1|root,COG0673@2|Bacteria,3Y2KV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD1_k127_7819063_0	656024.FsymDg_1678	3.923e-66	235.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD1_k127_7819063_2	234267.Acid_3175	3.204e-11	71.0	COG1075@1|root,COG1404@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	2|Bacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD1_k127_7827138_1	402777.KB235898_gene5191	5.725e-23	105.0	COG5640@1|root,COG5640@2|Bacteria,1G5D3@1117|Cyanobacteria,1HBY4@1150|Oscillatoriales	1117|Cyanobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Trypsin
HFD1_k127_7827138_0	234267.Acid_3952	0.0	1199.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PSCyt1,PSCyt2,PSD1
HFD1_k127_7829289_13	234267.Acid_6336	6.408e-28	114.0	COG2017@1|root,COG2017@2|Bacteria,3Y6TJ@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7829289_12	278963.ATWD01000001_gene1463	6.211e-34	145.0	COG0738@1|root,COG0738@2|Bacteria,3Y57Y@57723|Acidobacteria,2JJQE@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_7829289_0	234267.Acid_6599	0.0	1072.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7829289_3	234267.Acid_5336	2.887e-198	646.0	COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,3Y3IC@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD1_k127_7829289_2	234267.Acid_3891	3.761e-234	743.0	COG1228@1|root,COG4642@1|root,COG1228@2|Bacteria,COG4642@2|Bacteria,3Y539@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_7829289_5	234267.Acid_5529	5.315e-180	572.0	COG1312@1|root,COG1312@2|Bacteria,3Y693@57723|Acidobacteria	57723|Acidobacteria	G	D-mannonate dehydratase (UxuA)	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HFD1_k127_7829289_7	639030.JHVA01000001_gene2812	2.662e-90	303.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HFD1_k127_7829289_6	1267533.KB906736_gene1337	1.608e-123	406.0	COG4977@1|root,COG4977@2|Bacteria,3Y77K@57723|Acidobacteria,2JP14@204432|Acidobacteriia	204432|Acidobacteriia	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD1_k127_7829289_15	1035195.HMPREF9997_00102	1.142e-15	85.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,22NNU@1653|Corynebacteriaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7829289_11	1340493.JNIF01000003_gene2690	2.984e-37	149.0	2EDR9@1|root,33BZ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7829289_17	1123269.NX02_00370	6.164e-14	81.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2K1NT@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD1_k127_7829289_9	204669.Acid345_4155	1.652e-48	190.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HFD1_k127_7829289_16	1267533.KB906740_gene287	1.484e-14	86.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4214,SBBP,TPR_19
HFD1_k127_7829289_19	1206731.BAGB01000168_gene1297	0.0003731	52.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria,2GIWN@201174|Actinobacteria,4G1RS@85025|Nocardiaceae	201174|Actinobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_10,TPR_12,TPR_4,TPR_7
HFD1_k127_7829289_18	1506583.JQJY01000008_gene3897	3.466e-11	71.0	COG1917@1|root,COG1917@2|Bacteria,4NQ5U@976|Bacteroidetes,1I3YX@117743|Flavobacteriia,2NX02@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4437)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HFD1_k127_7829289_10	330214.NIDE3685	5.705e-42	161.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigK	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD1_k127_7829289_8	639030.JHVA01000001_gene2540	1.634e-81	292.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD1_k127_7829289_4	1267535.KB906767_gene4072	5.767e-194	610.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_7829289_1	1340493.JNIF01000003_gene4672	7.923e-244	767.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7833700_0	1125863.JAFN01000001_gene2253	4.056e-93	314.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_7833700_1	1125863.JAFN01000001_gene2827	5.552e-59	220.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HFD1_k127_7833700_2	269799.Gmet_2545	9.88e-38	150.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,43TDR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD1_k127_784463_12	204669.Acid345_2395	4.771e-17	82.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
HFD1_k127_784463_3	1267535.KB906767_gene4050	2.434e-87	296.0	2DN75@1|root,32VXD@2|Bacteria,3Y7CA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_784463_8	234267.Acid_4243	1.699e-32	139.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4243|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_784463_6	1519464.HY22_02245	1.3e-41	158.0	COG4914@1|root,COG4914@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
HFD1_k127_784463_0	234267.Acid_4539	0.0	1324.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HFD1_k127_784463_1	234267.Acid_4530	4.367e-203	637.0	2DB8U@1|root,2Z7SW@2|Bacteria,3Y3IM@57723|Acidobacteria	57723|Acidobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
HFD1_k127_784463_11	517433.PanABDRAFT_3574	8.778e-23	98.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,1SDHP@1236|Gammaproteobacteria,3W13K@53335|Pantoea	1236|Gammaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
HFD1_k127_784463_13	1201293.AKXQ01000010_gene3275	1.069e-09	71.0	COG4775@1|root,COG4775@2|Bacteria,1RDM0@1224|Proteobacteria,1SK9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HFD1_k127_784463_2	309807.SRU_0977	8.543e-88	316.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_784463_4	710696.Intca_2881	1.312e-42	171.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_784463_5	234267.Acid_0459	1.819e-42	159.0	COG1765@1|root,COG1765@2|Bacteria,3Y55G@57723|Acidobacteria	57723|Acidobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD1_k127_784463_7	671143.DAMO_3128	1.062e-34	137.0	COG0730@1|root,COG0730@2|Bacteria,2NRPD@2323|unclassified Bacteria	2|Bacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_7853589_4	234267.Acid_3677	2.621e-86	295.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_7853589_5	521674.Plim_4053	5.698e-51	191.0	COG1793@1|root,COG1793@2|Bacteria,2IYJZ@203682|Planctomycetes	203682|Planctomycetes	L	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD1_k127_7853589_1	1123242.JH636435_gene1407	1.356e-217	707.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Glyco_hydro_31
HFD1_k127_7853589_0	595460.RRSWK_04080	1.503e-220	692.0	COG3669@1|root,COG3669@2|Bacteria,2J4D6@203682|Planctomycetes	203682|Planctomycetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HFD1_k127_7853589_2	234267.Acid_2424	7.853e-210	665.0	28JXN@1|root,2Z9N3@2|Bacteria	2|Bacteria	S	PFAM FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HFD1_k127_7853589_3	448385.sce6976	9.052e-95	337.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
HFD1_k127_7863261_4	234267.Acid_3320	4.352e-10	61.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_7863261_0	234267.Acid_4063	9.074e-209	655.0	COG2421@1|root,COG2421@2|Bacteria,3Y7AP@57723|Acidobacteria	57723|Acidobacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HFD1_k127_7863261_1	234267.Acid_4466	1.269e-118	388.0	COG2367@1|root,COG2367@2|Bacteria,3Y3UF@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HFD1_k127_7863261_3	234267.Acid_4200	8.114e-56	196.0	COG0316@1|root,COG0316@2|Bacteria,3Y4ZB@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD1_k127_7863261_2	234267.Acid_4199	9.276e-91	305.0	COG1595@1|root,COG1595@2|Bacteria,3Y6TU@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_7868721_3	234267.Acid_3653	3.155e-67	248.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Lipase_2
HFD1_k127_7868721_0	234267.Acid_0296	1.094e-146	484.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria	57723|Acidobacteria	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HFD1_k127_7868721_2	234267.Acid_0295	3.689e-103	343.0	COG1974@1|root,COG1974@2|Bacteria,3Y813@57723|Acidobacteria	57723|Acidobacteria	KT	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7868721_1	234267.Acid_0294	1.998e-142	459.0	COG2304@1|root,COG2304@2|Bacteria,3Y6QE@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD1_k127_7884261_1	545276.KB898731_gene2155	2.292e-07	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_7884261_2	1144312.PMI09_02611	0.0001185	49.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
HFD1_k127_7884261_0	335543.Sfum_3200	1.909e-184	588.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MRB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
HFD1_k127_7887357_3	234267.Acid_3622	4.236e-64	230.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_7887357_2	234267.Acid_1185	1.423e-88	297.0	COG3132@1|root,COG3132@2|Bacteria,3Y5AG@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HFD1_k127_7887357_0	234267.Acid_1187	2.837e-102	337.0	COG0504@1|root,COG0504@2|Bacteria,3Y7VR@57723|Acidobacteria	57723|Acidobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD1_k127_7887357_1	234267.Acid_4526	4.161e-101	338.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7895838_2	234267.Acid_4526	1.627e-145	469.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7895838_8	234267.Acid_4525	4.677e-45	166.0	COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_7895838_1	234267.Acid_4149	1.473e-203	660.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	2|Bacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_7895838_3	1267535.KB906767_gene5199	1.38e-143	460.0	COG1082@1|root,COG1082@2|Bacteria,3Y78R@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD1_k127_7895838_6	234267.Acid_1442	9.139e-55	209.0	COG0642@1|root,COG2205@2|Bacteria	234267.Acid_1442|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7895838_0	234267.Acid_1443	4.124e-220	712.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	HEAT_2,NB-ARC,TLC,cNMP_binding
HFD1_k127_7895838_7	234267.Acid_1444	7.948e-54	192.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	CP_0464	-	1.8.1.9	ko:K00384,ko:K01999,ko:K07001,ko:K10914	ko00450,ko02010,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02010,map02020,map02024,map02025,map02026,map05111	M00237	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	3.A.1.4	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_7895838_4	234267.Acid_1445	4.864e-64	234.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS_4,PAS_9,dCache_1
HFD1_k127_7895838_5	234267.Acid_1446	3.879e-56	212.0	COG3437@1|root,COG3437@2|Bacteria,3Y907@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
HFD1_k127_7945774_8	439235.Dalk_0815	1.291e-61	230.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MNC9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD1_k127_7945774_9	522306.CAP2UW1_1998	3.461e-48	180.0	29VND@1|root,30H5P@2|Bacteria,1RBVN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7945774_14	929556.Solca_1806	7.828e-20	96.0	2E3RZ@1|root,32YPK@2|Bacteria,4NVPS@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7945774_16	1449076.JOOE01000002_gene928	1.858e-07	57.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,2K0MT@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_7945774_10	234267.Acid_2887	9.238e-34	135.0	COG0745@1|root,COG0745@2|Bacteria,3Y8Y3@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_7945774_5	204669.Acid345_4078	9.415e-87	296.0	COG4786@1|root,COG4786@2|Bacteria,3Y68I@57723|Acidobacteria,2JMAD@204432|Acidobacteriia	204432|Acidobacteriia	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HFD1_k127_7945774_4	204669.Acid345_4077	3.475e-97	334.0	COG3064@1|root,COG3064@2|Bacteria,3Y7SB@57723|Acidobacteria,2JN3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HFD1_k127_7945774_0	234267.Acid_4973	7.089e-186	595.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	ropAch1	-	-	-	-	-	-	-	-	-	-	-	Porin_2
HFD1_k127_7945774_1	234267.Acid_5408	1.041e-163	521.0	COG2066@1|root,COG2066@2|Bacteria,3Y743@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the glutaminase family	-	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HFD1_k127_7945774_2	234267.Acid_0447	1.05e-150	501.0	COG2159@1|root,COG2159@2|Bacteria,3Y7DZ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_7945774_15	1411123.JQNH01000001_gene44	1.139e-10	69.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2U93B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HFD1_k127_7945774_6	639030.JHVA01000001_gene2746	9.457e-83	292.0	COG2208@1|root,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
HFD1_k127_7945774_12	234267.Acid_0107	4.99e-28	118.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria	57723|Acidobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD1_k127_7945774_7	1121448.DGI_0551	2.043e-78	279.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MG89@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD1_k127_7945774_3	1403819.BATR01000183_gene6311	3.863e-126	413.0	COG0841@1|root,COG0841@2|Bacteria,46U0U@74201|Verrucomicrobia,2ITVP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_7962672_9	234267.Acid_1125	2.266e-23	101.0	29P8D@1|root,30A6G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
HFD1_k127_7962672_4	234267.Acid_1124	2.014e-142	459.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	-	-	2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HFD1_k127_7962672_1	234267.Acid_5208	3.521e-234	732.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM glutamate formiminotransferase	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HFD1_k127_7962672_7	1449351.RISW2_13285	7.496e-70	245.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TUY3@28211|Alphaproteobacteria,4KK9X@93682|Roseivivax	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_7962672_0	234267.Acid_5209	2.681e-312	962.0	COG2987@1|root,COG2987@2|Bacteria,3Y2VD@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HFD1_k127_7962672_3	234267.Acid_5207	4.034e-162	525.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD1_k127_7962672_2	234267.Acid_3748	4.043e-176	569.0	COG3534@1|root,COG3534@2|Bacteria,3Y48A@57723|Acidobacteria	2|Bacteria	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HFD1_k127_7962672_5	1340493.JNIF01000003_gene3420	2.337e-100	337.0	COG4977@1|root,COG4977@2|Bacteria,3Y2MK@57723|Acidobacteria	57723|Acidobacteria	K	AraC-type transcriptional regulator N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
HFD1_k127_7962672_6	1340493.JNIF01000003_gene1448	1.814e-73	268.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	CP_1076	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Autotransporter,DUF1929,Glyoxal_oxid_N,PA14
HFD1_k127_7962672_8	234267.Acid_3819	5.207e-49	184.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_805665_1	234267.Acid_7876	2.323e-95	331.0	2FAIU@1|root,342SV@2|Bacteria,3Y86W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_805665_2	234267.Acid_7877	7.266e-81	273.0	COG1376@1|root,COG1376@2|Bacteria,3Y7TU@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD1_k127_805665_0	234267.Acid_7878	2.864e-112	365.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_805665_3	234267.Acid_7879	1.993e-59	214.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD1_k127_813225_2	1278309.KB907099_gene2910	1.489e-34	143.0	COG2132@1|root,COG3828@1|root,COG2132@2|Bacteria,COG3828@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
HFD1_k127_813225_1	1535422.ND16A_1815	6.113e-130	430.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
HFD1_k127_813225_0	1278309.KB907099_gene2912	9.719e-134	438.0	COG2132@1|root,COG2132@2|Bacteria,1R89G@1224|Proteobacteria,1S5X0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_3
HFD1_k127_813225_3	378806.STAUR_0249	7.932e-24	114.0	COG2885@1|root,COG2885@2|Bacteria,1R4CA@1224|Proteobacteria,42RIU@68525|delta/epsilon subdivisions,2WNC0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4892,OmpA
HFD1_k127_825385_0	375286.mma_2202	1.814e-134	435.0	28NGF@1|root,2Z9HT@2|Bacteria,1R9QF@1224|Proteobacteria,2VPSU@28216|Betaproteobacteria,47599@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_825385_2	375286.mma_2203	9.475e-26	116.0	2E5FK@1|root,3307A@2|Bacteria,1N95D@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_83725_1	234267.Acid_0065	1.225e-210	665.0	COG1680@1|root,COG1680@2|Bacteria,3Y4J4@57723|Acidobacteria	57723|Acidobacteria	V	Domain of unknown function (DUF3471)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HFD1_k127_83725_8	1192034.CAP_4725	4.26e-81	302.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
HFD1_k127_83725_6	234267.Acid_0063	6.839e-99	342.0	COG1540@1|root,COG1540@2|Bacteria	2|Bacteria	S	5-oxoprolinase (ATP-hydrolyzing) activity	ybgL	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HFD1_k127_83725_5	234267.Acid_0062	8.129e-107	354.0	COG1984@1|root,COG1984@2|Bacteria,3Y7FI@57723|Acidobacteria	2|Bacteria	EI	Allophanate hydrolase subunit 2	kipA	-	3.5.1.54,6.3.4.6	ko:K01457,ko:K01941	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005,R00774	RC00378,RC02756	ko00000,ko00001,ko01000	-	-	-	CT_A_B,CT_C_D
HFD1_k127_83725_7	234267.Acid_0061	1.246e-87	294.0	COG2049@1|root,COG2049@2|Bacteria	2|Bacteria	E	5-oxoprolinase (ATP-hydrolyzing) activity	kipI	-	3.5.1.54,6.3.4.6	ko:K01457,ko:K01941,ko:K06351,ko:K07160	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005,R00774	RC00378,RC02756	ko00000,ko00001,ko01000	-	-	-	CT_C_D
HFD1_k127_83725_10	1380355.JNIJ01000020_gene3756	1.043e-23	105.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HFD1_k127_83725_0	234267.Acid_0060	2.131e-211	687.0	COG4485@1|root,COG4485@2|Bacteria	2|Bacteria	M	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD1_k127_83725_4	234267.Acid_0059	2.518e-172	550.0	COG2271@1|root,COG2271@2|Bacteria,3Y2KA@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major facilitator superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD1_k127_83725_3	234267.Acid_1835	2.083e-177	582.0	COG0531@1|root,COG0531@2|Bacteria,3Y4PR@57723|Acidobacteria	57723|Acidobacteria	E	PFAM amino acid permease-associated region	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HFD1_k127_83725_2	234267.Acid_1836	1.921e-187	597.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD1_k127_83725_9	234267.Acid_1837	9.123e-35	136.0	COG2423@1|root,COG2423@2|Bacteria,3Y82U@57723|Acidobacteria	57723|Acidobacteria	E	PFAM ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD1_k127_838557_14	1040989.AWZU01000017_gene3159	3.174e-52	197.0	COG0645@1|root,COG0645@2|Bacteria,1RHF4@1224|Proteobacteria,2UB3F@28211|Alphaproteobacteria,3JZ3N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
HFD1_k127_838557_19	1033734.CAET01000048_gene1636	1.504e-25	113.0	COG3278@1|root,COG3278@2|Bacteria,1VAHS@1239|Firmicutes,4HKKG@91061|Bacilli,1ZID0@1386|Bacillus	91061|Bacilli	O	COG3278 Cbb3-type cytochrome oxidase, subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HFD1_k127_838557_4	234267.Acid_3175	1.595e-149	507.0	COG1075@1|root,COG1404@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	2|Bacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD1_k127_838557_17	1340493.JNIF01000004_gene878	1.109e-41	175.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,3Y77C@57723|Acidobacteria	57723|Acidobacteria	G	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Peptidase_C14,TPR_2,WD40
HFD1_k127_838557_16	452637.Oter_3915	1.124e-44	172.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,TPMT
HFD1_k127_838557_2	234267.Acid_2629	2.767e-156	510.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_838557_0	234267.Acid_3422	2.74e-191	616.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	ykfB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_838557_5	234267.Acid_3421	1.225e-140	450.0	COG0791@1|root,COG0791@2|Bacteria,3Y5IG@57723|Acidobacteria	57723|Acidobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SPOR
HFD1_k127_838557_9	1340493.JNIF01000003_gene1390	8.165e-100	338.0	COG2010@1|root,COG2010@2|Bacteria,3Y5ZT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD1_k127_838557_6	1340493.JNIF01000003_gene2268	1.728e-137	448.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD1_k127_838557_10	234267.Acid_2581	2.267e-98	341.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HFD1_k127_838557_18	234267.Acid_3158	3.72e-38	146.0	COG0261@1|root,COG0261@2|Bacteria	2|Bacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HFD1_k127_838557_15	234267.Acid_3159	1.866e-45	164.0	COG0211@1|root,COG0211@2|Bacteria,3Y5D8@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HFD1_k127_838557_1	234267.Acid_3160	1.541e-177	562.0	COG0536@1|root,COG0536@2|Bacteria,3Y2J7@57723|Acidobacteria	57723|Acidobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HFD1_k127_838557_20	298655.KI912266_gene2423	1.059e-10	74.0	2DRPS@1|root,33CHR@2|Bacteria,2GXSD@201174|Actinobacteria,4EX0H@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_838557_12	234267.Acid_0297	1.005e-66	250.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT,PGAP1
HFD1_k127_838557_21	234267.Acid_5007	7.795e-08	61.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_838557_3	234267.Acid_4712	6.555e-151	497.0	COG1052@1|root,COG1052@2|Bacteria,3Y4PG@57723|Acidobacteria	57723|Acidobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD1_k127_838557_13	234267.Acid_4713	2.713e-54	201.0	COG2091@1|root,COG2091@2|Bacteria,3Y5WF@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD1_k127_838557_7	234267.Acid_4714	1.363e-129	422.0	COG0438@1|root,COG3208@1|root,COG0438@2|Bacteria,COG3208@2|Bacteria,3Y55B@57723|Acidobacteria	57723|Acidobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Thioesterase
HFD1_k127_840155_6	234267.Acid_0102	4.065e-16	83.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
HFD1_k127_840155_5	234267.Acid_0101	8.549e-28	114.0	2C5W1@1|root,2ZWMD@2|Bacteria,3Y8VN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_840155_0	1340493.JNIF01000003_gene1738	0.0	1246.0	COG1506@1|root,COG1506@2|Bacteria,3Y3XQ@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_840155_3	234267.Acid_1739	8.629e-88	301.0	COG1028@1|root,COG1028@2|Bacteria,3Y42B@57723|Acidobacteria	57723|Acidobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_840155_4	682795.AciX8_0080	6.211e-30	124.0	COG3682@1|root,COG3682@2|Bacteria,3Y57R@57723|Acidobacteria,2JN3S@204432|Acidobacteriia	204432|Acidobacteriia	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_840155_2	234267.Acid_0096	8.265e-120	407.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HFD1_k127_840155_1	234267.Acid_0094	3.374e-290	896.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_841726_1	1217718.ALOU01000083_gene2975	1.097e-25	109.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HFD1_k127_841726_0	1123393.KB891330_gene869	4.956e-74	269.0	28IJW@1|root,2Z8KR@2|Bacteria,1R45I@1224|Proteobacteria,2VK7H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_843764_7	1463825.JNXC01000001_gene5914	7.383e-08	58.0	COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4DZZE@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	namA	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
HFD1_k127_843764_5	196490.AUEZ01000036_gene6081	1.206e-52	211.0	COG3828@1|root,COG3828@2|Bacteria,1R5XA@1224|Proteobacteria,2U51F@28211|Alphaproteobacteria,3K5VQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	GSDH,ThuA
HFD1_k127_843764_0	234267.Acid_0217	0.0	1070.0	COG3408@1|root,COG3408@2|Bacteria,3Y6VF@57723|Acidobacteria	57723|Acidobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD1_k127_843764_2	234267.Acid_0218	8.516e-277	863.0	COG0296@1|root,COG0296@2|Bacteria,3Y33J@57723|Acidobacteria	57723|Acidobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HFD1_k127_843764_1	1267535.KB906767_gene1150	0.0	1058.0	COG1523@1|root,COG1523@2|Bacteria,3Y3YA@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HFD1_k127_843764_3	234267.Acid_1901	2.408e-275	850.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glutamine synthetase, catalytic	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD1_k127_843764_6	234267.Acid_0466	2.871e-45	167.0	COG0355@1|root,COG0355@2|Bacteria,3Y5VV@57723|Acidobacteria	57723|Acidobacteria	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HFD1_k127_843764_4	234267.Acid_0465	2.42e-65	224.0	COG0055@1|root,COG0055@2|Bacteria,3Y2PU@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD1_k127_853852_5	234267.Acid_5004	1.034e-38	145.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_853852_3	1123367.C666_16415	2.237e-83	282.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,2VI8R@28216|Betaproteobacteria,2KUIF@206389|Rhodocyclales	206389|Rhodocyclales	C	Cob(II)yrinic acid a,c-diamide reductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HFD1_k127_853852_1	639030.JHVA01000001_gene1998	0.0	1163.0	COG3485@1|root,COG3485@2|Bacteria,3Y3VM@57723|Acidobacteria,2JHSQ@204432|Acidobacteriia	204432|Acidobacteriia	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD1_k127_853852_2	1340493.JNIF01000003_gene3750	3.963e-135	439.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria	2|Bacteria	P	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,PBP_like,Peptidase_M78
HFD1_k127_853852_0	234267.Acid_1665	0.0	1762.0	COG0209@1|root,COG0209@2|Bacteria,3Y3Q1@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD1_k127_853852_4	234267.Acid_0139	1.495e-57	202.0	COG3485@1|root,COG3485@2|Bacteria	234267.Acid_0139|-	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_910836_2	176946.XP_007432938.1	0.0001491	55.0	2B3UB@1|root,2S0FI@2759|Eukaryota,3A17Q@33154|Opisthokonta,3BPWU@33208|Metazoa,3D6R0@33213|Bilateria,48EED@7711|Chordata,49BDB@7742|Vertebrata	33208|Metazoa	S	Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins.	-	-	-	-	-	-	-	-	-	-	-	-	Hyd_WA
HFD1_k127_910836_1	234267.Acid_0627	2.136e-28	133.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHU_C,Cadherin-like,ChW,F5_F8_type_C,fn3
HFD1_k127_910836_0	234267.Acid_7109	1.034e-141	454.0	COG3669@1|root,COG3669@2|Bacteria,3Y6KY@57723|Acidobacteria	57723|Acidobacteria	G	Alpha-L-fucosidase C-terminal domain	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HFD1_k127_914439_2	861299.J421_0949	5.002e-151	509.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0949|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_914439_3	234267.Acid_1028	5.95e-32	125.0	COG2331@1|root,COG2331@2|Bacteria,3Y92S@57723|Acidobacteria	57723|Acidobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD1_k127_914439_0	234267.Acid_1026	1.271e-186	615.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD1_k127_914439_1	234267.Acid_1025	2.418e-165	528.0	COG0738@1|root,COG0738@2|Bacteria,3Y6YP@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_918097_3	1121438.JNJA01000021_gene1358	4.594e-54	207.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,42V19@68525|delta/epsilon subdivisions,2WSZV@28221|Deltaproteobacteria,2M9MV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_918097_2	926560.KE387027_gene532	2.377e-134	445.0	COG0654@1|root,COG0654@2|Bacteria,1WMEV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_918097_1	234267.Acid_4761	4.208e-254	787.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD1_k127_918097_0	234267.Acid_4760	0.0	1117.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria	57723|Acidobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD1_k127_919769_1	234267.Acid_4062	4.328e-20	105.0	COG3391@1|root,COG4447@1|root,COG3391@2|Bacteria,COG4447@2|Bacteria,3Y31A@57723|Acidobacteria	57723|Acidobacteria	U	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_919769_0	234267.Acid_2832	3.764e-22	99.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_920014_8	1340493.JNIF01000003_gene1496	3.229e-50	186.0	COG2877@1|root,COG2877@2|Bacteria,3Y2WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM DAHP synthetase I	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD1_k127_920014_0	234267.Acid_6215	5.492e-317	980.0	COG0504@1|root,COG0504@2|Bacteria,3Y2MH@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD1_k127_920014_5	234267.Acid_6216	1.79e-113	370.0	COG1212@1|root,COG1212@2|Bacteria,3Y4GZ@57723|Acidobacteria	57723|Acidobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HFD1_k127_920014_3	234267.Acid_6217	3.82e-152	486.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD1_k127_920014_4	234267.Acid_6218	7.509e-135	437.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD1_k127_920014_9	1340493.JNIF01000003_gene2458	5.015e-21	93.0	2EKYQ@1|root,33EN7@2|Bacteria,3Y5T5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_920014_1	1267535.KB906767_gene4053	1.397e-309	968.0	COG1629@1|root,COG4771@2|Bacteria,3Y36N@57723|Acidobacteria,2JI4W@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD1_k127_920014_6	234267.Acid_1131	8.394e-91	306.0	COG3279@1|root,COG3279@2|Bacteria,3Y6CD@57723|Acidobacteria	57723|Acidobacteria	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD1_k127_920014_2	234267.Acid_1132	2.547e-190	611.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
HFD1_k127_920014_7	234267.Acid_2756	1.418e-78	277.0	COG2755@1|root,COG2755@2|Bacteria,3Y2KK@57723|Acidobacteria	2|Bacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD1_k127_922372_7	234267.Acid_1202	0.0002626	45.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD1_k127_922372_0	234267.Acid_4582	0.0	1200.0	COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria	57723|Acidobacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
HFD1_k127_922372_3	1267535.KB906767_gene4659	8.154e-125	406.0	COG0266@1|root,COG0266@2|Bacteria,3Y71J@57723|Acidobacteria,2JKGK@204432|Acidobacteriia	204432|Acidobacteriia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD1_k127_922372_6	1169143.KB911039_gene4339	2.941e-15	84.0	COG3631@1|root,COG3631@2|Bacteria,1RI6F@1224|Proteobacteria,2WEA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HFD1_k127_922372_1	234267.Acid_1908	2.041e-199	628.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3Y339@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD1_k127_922372_4	234267.Acid_1907	2.892e-74	262.0	2FA03@1|root,34298@2|Bacteria,3Y84H@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_922372_2	234267.Acid_5165	2.52e-145	466.0	COG1064@1|root,COG1064@2|Bacteria,3Y34K@57723|Acidobacteria	57723|Acidobacteria	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD1_k127_922372_5	1183438.GKIL_4239	1.281e-67	236.0	COG0120@1|root,COG0120@2|Bacteria,1G2DW@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rpiA	Rib_5-P_isom_A
HFD1_k127_945491_1	234267.Acid_6603	0.0	1071.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HFD1_k127_945491_0	234267.Acid_6602	0.0	1153.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,3Y2QH@57723|Acidobacteria	57723|Acidobacteria	M	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HFD1_k127_945491_3	1267535.KB906767_gene5445	2.041e-95	323.0	COG1651@1|root,COG1651@2|Bacteria,3Y9G4@57723|Acidobacteria,2JNEF@204432|Acidobacteriia	204432|Acidobacteriia	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_945491_2	234267.Acid_5245	1.091e-199	634.0	COG0577@1|root,COG0577@2|Bacteria,3Y6IX@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_961892_22	234267.Acid_6757	2.999e-92	310.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,3Y2KW@57723|Acidobacteria	57723|Acidobacteria	CO	Thioredoxin-like	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HFD1_k127_961892_12	234267.Acid_6758	6.301e-163	518.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD1_k127_961892_37	234267.Acid_6759	3.486e-30	119.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HFD1_k127_961892_25	234267.Acid_6760	3.306e-77	262.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HFD1_k127_961892_24	234267.Acid_1225	6.344e-79	295.0	COG3391@1|root,COG3391@2|Bacteria,3Y98W@57723|Acidobacteria	57723|Acidobacteria	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD1_k127_961892_32	234267.Acid_2176	9.824e-39	152.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD1_k127_961892_11	234267.Acid_5876	1.53e-166	528.0	COG0667@1|root,COG0667@2|Bacteria,3Y3KW@57723|Acidobacteria	57723|Acidobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_961892_8	234267.Acid_5875	2.454e-195	619.0	COG1233@1|root,COG1233@2|Bacteria,3Y319@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HFD1_k127_961892_36	234267.Acid_1324	1.026e-32	147.0	COG4219@1|root,COG4219@2|Bacteria,3Y7YA@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD1_k127_961892_13	234267.Acid_2317	2.273e-153	499.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HFD1_k127_961892_6	1267535.KB906767_gene4246	2.854e-225	704.0	COG3119@1|root,COG3119@2|Bacteria,3Y679@57723|Acidobacteria	57723|Acidobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HFD1_k127_961892_23	234267.Acid_1436	2.293e-81	283.0	COG3684@1|root,COG3981@1|root,COG3684@2|Bacteria,COG3981@2|Bacteria,3Y33H@57723|Acidobacteria	57723|Acidobacteria	G	deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD1_k127_961892_19	234267.Acid_3882	2.627e-107	355.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_961892_7	234267.Acid_3086	8.551e-209	687.0	COG3525@1|root,COG3525@2|Bacteria,3Y2P0@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Glycoside hydrolase, family 20	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
HFD1_k127_961892_14	929713.NIASO_15660	1.54e-152	494.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes	976|Bacteroidetes	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
HFD1_k127_961892_29	1218173.BALCAV_0213010	1.503e-53	204.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,1ZC4Y@1386|Bacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
HFD1_k127_961892_16	357808.RoseRS_3954	1.266e-118	397.0	COG0399@1|root,COG0399@2|Bacteria,2G7WW@200795|Chloroflexi,37751@32061|Chloroflexia	32061|Chloroflexia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD1_k127_961892_15	1121904.ARBP01000042_gene4905	1.669e-124	426.0	COG3292@1|root,COG3292@2|Bacteria,4NF9I@976|Bacteroidetes,47XHD@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
HFD1_k127_961892_18	886293.Sinac_3363	1.546e-113	379.0	COG4299@1|root,COG4299@2|Bacteria,2IYKU@203682|Planctomycetes	203682|Planctomycetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD1_k127_961892_1	1267535.KB906767_gene1828	3.043e-321	999.0	COG3518@1|root,COG3518@2|Bacteria	2|Bacteria	S	anti-sigma factor antagonist activity	iraD	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042176,GO:0042177,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11897,ko:K21637	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
HFD1_k127_961892_20	1196323.ALKF01000197_gene2265	3.125e-102	364.0	COG3119@1|root,COG3119@2|Bacteria,1UDRD@1239|Firmicutes,4HD9J@91061|Bacilli,26R87@186822|Paenibacillaceae	91061|Bacilli	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD1_k127_961892_3	234267.Acid_1905	5.548e-289	910.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HFD1_k127_961892_0	234267.Acid_1906	0.0	1217.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.6.4.12	ko:K01144,ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF3799,PDDEXK_1,UvrD-helicase,UvrD_C
HFD1_k127_961892_35	234267.Acid_1511	2.124e-33	136.0	COG3618@1|root,COG3618@2|Bacteria	234267.Acid_1511|-	H	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_961892_5	234267.Acid_1510	1.23e-247	777.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD1_k127_961892_4	234267.Acid_1509	3.214e-268	835.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_961892_28	234267.Acid_3723	1.163e-56	203.0	COG0457@1|root,COG0457@2|Bacteria,3Y7T2@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
HFD1_k127_961892_17	234267.Acid_5466	6.409e-115	406.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD1_k127_961892_33	1267533.KB906736_gene1023	4.014e-37	142.0	COG1695@1|root,COG1695@2|Bacteria,3Y7W2@57723|Acidobacteria,2JN2W@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_961892_40	1123072.AUDH01000012_gene3567	1.463e-05	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_961892_26	665956.HMPREF1032_02227	6.231e-66	244.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,3WJ8B@541000|Ruminococcaceae	186801|Clostridia	P	Transporter, CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD1_k127_961892_34	234267.Acid_5072	1.1e-35	146.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,Dala_Dala_lig_C,RLAN,RimK
HFD1_k127_961892_31	234267.Acid_5073	1.205e-39	150.0	COG1918@1|root,COG1918@2|Bacteria,3Y92B@57723|Acidobacteria	57723|Acidobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HFD1_k127_961892_2	234267.Acid_5074	1.037e-291	906.0	COG0370@1|root,COG0370@2|Bacteria,3Y3CZ@57723|Acidobacteria	57723|Acidobacteria	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HFD1_k127_961892_21	234267.Acid_2142	4.225e-95	315.0	COG2264@1|root,COG2264@2|Bacteria	2|Bacteria	J	protein methyltransferase activity	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_25,Methyltransf_31,PrmA
HFD1_k127_961892_10	234267.Acid_5500	7.131e-178	564.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	HemolysinCabind,Pro_isomerase
HFD1_k127_961892_27	278963.ATWD01000002_gene251	5.209e-62	226.0	COG1413@1|root,COG1413@2|Bacteria,3Y4Z5@57723|Acidobacteria,2JJG6@204432|Acidobacteriia	204432|Acidobacteriia	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD1_k127_961892_9	234267.Acid_0024	2.885e-187	616.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD1_k127_961892_39	715226.ABI_43700	3.963e-11	70.0	COG1266@1|root,COG4188@1|root,COG1266@2|Bacteria,COG4188@2|Bacteria,1N436@1224|Proteobacteria,2UF08@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HFD1_k127_961892_30	1265505.ATUG01000002_gene2495	5.468e-53	198.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,2MM84@213118|Desulfobacterales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HFD1_k127_961892_38	743836.AYNA01000008_gene1707	5.765e-29	124.0	COG1192@1|root,COG1192@2|Bacteria,1QWRJ@1224|Proteobacteria,2UWW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HFD1_k127_963349_5	234267.Acid_3567	2.601e-36	139.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD1_k127_963349_1	240015.ACP_1172	1.839e-121	408.0	COG0457@1|root,COG0457@2|Bacteria,3Y77J@57723|Acidobacteria,2JM29@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD1_k127_963349_4	234267.Acid_4767	1.073e-111	370.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	DUF3500
HFD1_k127_963349_2	234267.Acid_3566	1.358e-119	390.0	COG3823@1|root,COG3823@2|Bacteria,3Y4G6@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glutamine cyclotransferase	-	-	2.3.2.5	ko:K00683	-	-	-	-	ko00000,ko01000	-	-	-	Glu_cyclase_2
HFD1_k127_963349_3	379066.GAU_0971	2.626e-113	381.0	COG1228@1|root,COG1228@2|Bacteria,1ZUSA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_963349_0	886293.Sinac_0682	1.776e-146	484.0	COG0627@1|root,COG0627@2|Bacteria,2J56R@203682|Planctomycetes	203682|Planctomycetes	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	-
## 5602 queries scanned
## Total time (seconds): 641.2015962600708
## Rate: 8.74 q/s