## Tue Nov 12 09:07:01 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD2_bin.1.fa -m mmseqs --itype genome -o HFD2_bin.1 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD2_bin.1 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD2_k127_1019017_1	234267.Acid_1153	8.806e-145	465.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HFD2_k127_1019017_0	1267535.KB906767_gene5480	0.0	1069.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3Y3X3@57723|Acidobacteria,2JHXN@204432|Acidobacteriia	204432|Acidobacteriia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD2_k127_1019017_4	1267535.KB906767_gene1470	1.755e-13	76.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	gcd2	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_1019017_2	1267535.KB906767_gene1342	1.343e-140	452.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD2_k127_1021689_1	234267.Acid_1734	4.009e-183	589.0	COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_1021689_3	1267535.KB906767_gene3077	8.656e-116	375.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1021689_2	234267.Acid_7936	9.87e-162	540.0	COG1566@1|root,COG1566@2|Bacteria,3Y9B7@57723|Acidobacteria	57723|Acidobacteria	V	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_1021689_0	1340493.JNIF01000003_gene1741	2.566e-200	631.0	COG0129@1|root,COG0129@2|Bacteria,3Y372@57723|Acidobacteria	57723|Acidobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_1054696_7	452637.Oter_3977	7.136e-27	111.0	COG2605@1|root,COG2605@2|Bacteria,46UPC@74201|Verrucomicrobia	74201|Verrucomicrobia	H	GHMP kinase domain protein	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_1054696_8	234267.Acid_0417	3.019e-13	70.0	COG0673@1|root,COG0673@2|Bacteria,3Y6M3@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_1054696_1	234267.Acid_0417	1.101e-126	409.0	COG0673@1|root,COG0673@2|Bacteria,3Y6M3@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_1054696_3	234267.Acid_0575	3.383e-89	299.0	COG1215@1|root,COG1215@2|Bacteria,3Y3PN@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1054696_0	671143.DAMO_0933	2.348e-150	486.0	COG0451@1|root,COG0451@2|Bacteria,2NQSZ@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_1054696_2	671143.DAMO_0928	1.267e-91	316.0	COG1216@1|root,COG1216@2|Bacteria,2NPQN@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
HFD2_k127_1054696_5	517722.AEUE01000002_gene2035	4.332e-39	154.0	COG2242@1|root,COG2242@2|Bacteria,1N02B@1224|Proteobacteria,2UECZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD2_k127_1054696_4	105559.Nwat_1066	9.976e-44	171.0	COG1404@1|root,COG1404@2|Bacteria,1R90Q@1224|Proteobacteria,1S01H@1236|Gammaproteobacteria,1X029@135613|Chromatiales	135613|Chromatiales	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_1076665_9	1267534.KB906756_gene712	1.198e-43	165.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1076665_5	1117379.BABA_14322	3.981e-135	442.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,1ZHB1@1386|Bacillus	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_1076665_0	1267535.KB906767_gene1049	3.289e-232	727.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
HFD2_k127_1076665_15	518766.Rmar_1678	6.442e-23	103.0	COG1310@1|root,COG1310@2|Bacteria,4NTI0@976|Bacteroidetes,1FJCV@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HFD2_k127_1076665_4	234267.Acid_0758	6.937e-143	459.0	COG0031@1|root,COG0031@2|Bacteria,3Y39M@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_1076665_19	1340493.JNIF01000003_gene1428	5.305e-06	53.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
HFD2_k127_1076665_7	1267533.KB906736_gene1436	4.608e-73	251.0	COG3861@1|root,COG3861@2|Bacteria,3Y5WZ@57723|Acidobacteria,2JM78@204432|Acidobacteriia	204432|Acidobacteriia	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD2_k127_1076665_14	204669.Acid345_1119	4.65e-24	108.0	COG2823@1|root,COG2823@2|Bacteria,3Y8FT@57723|Acidobacteria,2JNE8@204432|Acidobacteriia	204432|Acidobacteriia	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_1076665_10	1125973.JNLC01000010_gene1801	4.323e-43	162.0	COG1853@1|root,COG1853@2|Bacteria,1RI5F@1224|Proteobacteria,2UD25@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD2_k127_1076665_12	136993.KB900627_gene392	3.685e-35	145.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1076665_2	234267.Acid_0368	2.576e-194	615.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD2_k127_1076665_3	234267.Acid_1046	1.466e-152	485.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD2_k127_1076665_17	555793.WSK_1435	1.374e-11	70.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1076665_11	1279017.AQYJ01000028_gene2525	7.611e-40	164.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1076665_13	338969.Rfer_1981	3.783e-25	115.0	COG1639@1|root,COG1639@2|Bacteria,1R4P9@1224|Proteobacteria,2VJZK@28216|Betaproteobacteria,4ACTZ@80864|Comamonadaceae	28216|Betaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
HFD2_k127_1076665_6	1007104.SUS17_2461	2.242e-110	371.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,2K0QG@204457|Sphingomonadales	204457|Sphingomonadales	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD2_k127_1076665_16	1267534.KB906757_gene857	1.78e-19	99.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,Lactonase,Laminin_G_3,VCBS,VPEP
HFD2_k127_1076665_1	234267.Acid_5749	2.151e-225	725.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1090907_6	1038859.AXAU01000001_gene3393	9.16e-17	83.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U0ZD@28211|Alphaproteobacteria,3JY8Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
HFD2_k127_1090907_3	1340493.JNIF01000003_gene2352	3.523e-67	234.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_1090907_4	1238182.C882_2716	5.879e-57	202.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,2U72T@28211|Alphaproteobacteria,2JS5I@204441|Rhodospirillales	204441|Rhodospirillales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
HFD2_k127_1090907_1	1380391.JIAS01000012_gene4348	3.185e-248	775.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2JQZQ@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1905 NADH ubiquinone oxidoreductase 24 kD subunit	-	-	1.12.1.2	ko:K00124,ko:K18005	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
HFD2_k127_1090907_0	1502851.FG93_02197	0.0	1528.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,3JTEA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdsA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HFD2_k127_1090907_8	391613.RTM1035_07128	3.836e-12	68.0	2E4CR@1|root,32Z86@2|Bacteria,1N7UZ@1224|Proteobacteria,2UF9N@28211|Alphaproteobacteria,46RB7@74030|Roseovarius	28211|Alphaproteobacteria	C	NADH-dependant formate dehydrogenase delta subunit FdsD	fdsD	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
HFD2_k127_1090907_7	1267533.KB906735_gene4696	1.196e-14	85.0	2DKZK@1|root,310GY@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3011)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3011
HFD2_k127_1090907_5	234267.Acid_2726	7.651e-36	148.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1090907_2	234267.Acid_1540	1.308e-80	273.0	COG4798@1|root,COG4798@2|Bacteria,3Y5JR@57723|Acidobacteria	57723|Acidobacteria	S	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HFD2_k127_1099130_7	1267535.KB906767_gene3537	1.142e-05	56.0	2DRPK@1|root,32URD@2|Bacteria,3Y4UQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1099130_0	1267535.KB906767_gene629	3.08e-219	687.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_1099130_2	1340493.JNIF01000003_gene4409	1.336e-173	555.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HFD2_k127_1099130_4	234267.Acid_2629	7.61e-77	282.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_1099130_6	234267.Acid_6886	1.757e-33	138.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigX	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1099130_1	234267.Acid_6692	4.04e-178	574.0	COG4191@1|root,COG4191@2|Bacteria,3Y4SZ@57723|Acidobacteria	57723|Acidobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
HFD2_k127_1099130_5	1267535.KB906767_gene1698	4.464e-70	245.0	COG3794@1|root,COG3794@2|Bacteria,3Y4UD@57723|Acidobacteria,2JJH0@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1099130_3	234267.Acid_6694	4.61e-94	318.0	2E98K@1|root,333GZ@2|Bacteria,3Y55V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1103249_4	234267.Acid_6497	2.737e-74	263.0	COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,3Y3X5@57723|Acidobacteria	57723|Acidobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N,LpxK
HFD2_k127_1103249_5	234267.Acid_4829	2.264e-58	209.0	COG1057@1|root,COG1057@2|Bacteria,3Y5D2@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_1103249_8	1382359.JIAL01000001_gene792	1.565e-33	136.0	COG3678@1|root,COG3678@2|Bacteria,3Y5A6@57723|Acidobacteria,2JJQD@204432|Acidobacteriia	204432|Acidobacteriia	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HFD2_k127_1103249_6	234267.Acid_2546	3.351e-55	199.0	COG1595@1|root,COG1595@2|Bacteria,3Y50V@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1103249_1	234267.Acid_3351	4.748e-147	472.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_1103249_9	1267535.KB906767_gene4524	2.376e-33	134.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria,2JNE1@204432|Acidobacteriia	204432|Acidobacteriia	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_1103249_3	1340493.JNIF01000003_gene3781	2.756e-97	325.0	COG0084@1|root,COG0084@2|Bacteria,3Y4DK@57723|Acidobacteria	57723|Acidobacteria	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD2_k127_1103249_0	234267.Acid_3353	4.282e-276	861.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria	57723|Acidobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD2_k127_1103249_2	1267535.KB906767_gene5356	9.299e-140	453.0	COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD2_k127_1103249_7	234267.Acid_5375	3.521e-46	172.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_110607_3	234267.Acid_6567	3.52e-114	374.0	COG0826@1|root,COG0826@2|Bacteria,3Y7M5@57723|Acidobacteria	57723|Acidobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HFD2_k127_110607_8	1437824.BN940_06841	3.787e-22	106.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,2VI8T@28216|Betaproteobacteria,3T40K@506|Alcaligenaceae	28216|Betaproteobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD2_k127_110607_7	639030.JHVA01000001_gene2793	7.735e-31	130.0	COG1881@1|root,COG1881@2|Bacteria,3Y5UH@57723|Acidobacteria,2JNWC@204432|Acidobacteriia	204432|Acidobacteriia	S	Phosphatidylethanolamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PBP
HFD2_k127_110607_2	234267.Acid_1641	6.492e-148	483.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_110607_5	1121033.AUCF01000003_gene3041	6.798e-65	230.0	COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2TTXQ@28211|Alphaproteobacteria,2JWHU@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_110607_4	234267.Acid_3892	3.135e-96	323.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_110607_9	935948.KE386495_gene2194	6.554e-10	65.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,42H30@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
HFD2_k127_110607_6	1089545.KB913037_gene8246	2.946e-40	160.0	COG0596@1|root,COG0596@2|Bacteria,2I8EU@201174|Actinobacteria,4E4HV@85010|Pseudonocardiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	lipV	GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575	-	ko:K19311	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_110607_10	1047013.AQSP01000106_gene1763	4.104e-05	57.0	COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria	2|Bacteria	P	COGs COG1629 Outer membrane receptor protein mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_110607_1	1210884.HG799465_gene11817	1.866e-156	517.0	COG3827@1|root,COG3827@2|Bacteria,2IXVY@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_110607_0	234267.Acid_4317	4.516e-314	983.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	LVIVD,SBP56
HFD2_k127_1112123_1	1267535.KB906767_gene717	4.947e-161	512.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD2_k127_1112123_6	1340493.JNIF01000004_gene766	1.602e-21	95.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD2_k127_1112123_4	582515.KR51_00007560	4.966e-66	232.0	COG0496@1|root,COG0496@2|Bacteria,1G30G@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Survival protein SurE	-	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD2_k127_1112123_7	1242864.D187_007797	3.532e-06	55.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YXK2@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_1112123_2	234267.Acid_1554	1.732e-74	260.0	COG0546@1|root,COG0546@2|Bacteria,3Y5BW@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_1112123_3	1267535.KB906767_gene1327	1.785e-73	250.0	2F1AE@1|root,33UBD@2|Bacteria,3Y7PJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1112123_5	234267.Acid_1340	4.679e-60	210.0	COG2128@1|root,COG2128@2|Bacteria,3Y7P9@57723|Acidobacteria	57723|Acidobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_1112123_0	749927.AMED_5336	2.445e-167	542.0	2DBY3@1|root,2ZBT7@2|Bacteria,2I773@201174|Actinobacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	-	-	-	-	-	-	-	-	-	DUF839
HFD2_k127_1119715_4	1165096.ARWF01000001_gene485	4.54e-49	176.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VHA9@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	rfbH	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_1119715_2	234267.Acid_2247	1.037e-134	441.0	COG0451@1|root,COG0451@2|Bacteria,3Y2YK@57723|Acidobacteria	57723|Acidobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_1119715_5	159450.NH14_11595	4.511e-11	70.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VRPK@28216|Betaproteobacteria,1K822@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD2_k127_1119715_3	159450.NH14_11590	1.216e-84	287.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2VSVY@28216|Betaproteobacteria,1K9PN@119060|Burkholderiaceae	28216|Betaproteobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.71	ko:K15669	ko00540,map00540	-	R09772	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HFD2_k127_1119715_1	864073.HFRIS_000800	1.393e-194	618.0	COG2605@1|root,COG2605@2|Bacteria,1PKV9@1224|Proteobacteria,2VKPX@28216|Betaproteobacteria,477J8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_1119715_0	864073.HFRIS_000805	2.5e-244	770.0	COG1082@1|root,COG2089@1|root,COG1082@2|Bacteria,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2VHMH@28216|Betaproteobacteria,472NV@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	NeuB family	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,CBS,NeuB,SAF
HFD2_k127_1126937_1	234267.Acid_0334	3.653e-131	434.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
HFD2_k127_1126937_0	1340493.JNIF01000003_gene2971	1.509e-154	500.0	COG2270@1|root,COG2270@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HFD2_k127_1126937_2	1267535.KB906767_gene4171	2.011e-44	171.0	2F5GG@1|root,33Y23@2|Bacteria,3Y7UU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1126937_3	1340493.JNIF01000003_gene3673	2.218e-25	110.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HFD2_k127_114111_1	234267.Acid_1337	3.101e-56	209.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase
HFD2_k127_114111_0	504832.OCAR_5303	7.925e-179	565.0	COG1893@1|root,COG1893@2|Bacteria,1QMH8@1224|Proteobacteria,2TSGW@28211|Alphaproteobacteria,3JWCH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_114111_2	292459.STH554	6.015e-38	156.0	COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,249N0@186801|Clostridia	186801|Clostridia	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
HFD2_k127_1150461_0	234267.Acid_5429	0.0	1398.0	COG0841@1|root,COG0841@2|Bacteria,3Y63J@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD2_k127_1150461_5	661478.OP10G_0670	3.049e-45	171.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria	2|Bacteria	Q	AAA domain	prpA	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
HFD2_k127_1150461_2	633149.Bresu_2027	2.29e-114	386.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria,2KI78@204458|Caulobacterales	204458|Caulobacterales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_1150461_3	1340493.JNIF01000003_gene2357	1.137e-94	326.0	COG2271@1|root,COG2271@2|Bacteria,3Y7EW@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD2_k127_1150461_4	240015.ACP_2023	3.409e-52	192.0	COG5424@1|root,COG5424@2|Bacteria,3Y718@57723|Acidobacteria,2JKMM@204432|Acidobacteriia	204432|Acidobacteriia	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HFD2_k127_1150461_1	1125973.JNLC01000010_gene1962	6.103e-128	420.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,3JURU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Reductase C-terminal	MA20_16930	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
HFD2_k127_1150461_6	1172181.KB911739_gene6601	2.442e-38	145.0	COG0633@1|root,COG0633@2|Bacteria,2GRQF@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HFD2_k127_1150461_7	1340493.JNIF01000004_gene240	7.678e-22	101.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_2,TonB_C
HFD2_k127_1157430_10	1340493.JNIF01000003_gene2680	6.139e-119	384.0	COG1215@1|root,COG1215@2|Bacteria,3Y5K6@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1157430_13	868131.MSWAN_1592	2.892e-33	145.0	COG1216@1|root,arCOG01383@2157|Archaea,2XW51@28890|Euryarchaeota,23NQW@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1157430_11	234267.Acid_7441	1.332e-77	271.0	COG1216@1|root,COG1216@2|Bacteria,3Y7JI@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HFD2_k127_1157430_2	234267.Acid_7442	3.344e-173	548.0	COG1216@1|root,COG1216@2|Bacteria,3Y7CJ@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1157430_6	234267.Acid_7443	6.006e-153	496.0	COG0438@1|root,COG0438@2|Bacteria,3Y6A8@57723|Acidobacteria	57723|Acidobacteria	M	Domain of unknown function (DUF1972)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1972,Glyco_trans_1_4
HFD2_k127_1157430_7	1267535.KB906767_gene4175	1.732e-144	466.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria,2JI6I@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_1157430_12	639030.JHVA01000001_gene2793	1.658e-57	206.0	COG1881@1|root,COG1881@2|Bacteria,3Y5UH@57723|Acidobacteria,2JNWC@204432|Acidobacteriia	204432|Acidobacteriia	S	Phosphatidylethanolamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PBP
HFD2_k127_1157430_0	1267535.KB906767_gene3183	0.0	1239.0	COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria,2JI1D@204432|Acidobacteriia	204432|Acidobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD2_k127_1157430_5	1267535.KB906767_gene3182	3.792e-157	504.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria,2JI4X@204432|Acidobacteriia	204432|Acidobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD2_k127_1157430_1	1340493.JNIF01000003_gene2671	2.374e-176	564.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria	57723|Acidobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD2_k127_1157430_9	1267535.KB906767_gene633	3.106e-127	419.0	COG0845@1|root,COG0845@2|Bacteria,3Y2FV@57723|Acidobacteria,2JHN2@204432|Acidobacteriia	204432|Acidobacteriia	M	MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
HFD2_k127_1157430_8	1267535.KB906767_gene632	3.226e-130	417.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1157430_4	1340493.JNIF01000003_gene1307	4.294e-169	544.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD2_k127_1157430_3	1379270.AUXF01000007_gene1066	1.782e-169	544.0	COG0318@1|root,COG0318@2|Bacteria,1ZUMN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_1157430_14	1340493.JNIF01000003_gene4497	7.783e-15	78.0	COG0297@1|root,COG0297@2|Bacteria,3Y3IH@57723|Acidobacteria	57723|Acidobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD2_k127_1168369_0	566466.NOR53_631	9.201e-143	471.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HFD2_k127_1168369_1	472175.EL18_02301	5.129e-16	80.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,2U56J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3,TAT_signal
HFD2_k127_1175738_1	234267.Acid_1441	7.142e-92	314.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_1175738_4	234267.Acid_1440	5.408e-57	208.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	6.5.1.3	ko:K14680	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2,RNA_lig_T4_1
HFD2_k127_1175738_0	448385.sce6263	2.494e-107	363.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
HFD2_k127_1175738_2	448385.sce6976	8.828e-84	306.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K01932,ko:K03301	-	-	-	-	ko00000,ko01000	2.A.12	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC
HFD2_k127_1175738_5	1038859.AXAU01000009_gene1553	1.059e-40	155.0	COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2UAYB@28211|Alphaproteobacteria,3JU65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	MA20_26800	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_1175738_3	1267535.KB906767_gene3339	4.185e-57	201.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria,2JIXA@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_1209816_2	935840.JAEQ01000029_gene669	5.641e-132	430.0	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,2TURU@28211|Alphaproteobacteria,43J77@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD2_k127_1209816_8	234267.Acid_7300	2.556e-51	185.0	COG0432@1|root,COG0432@2|Bacteria,3Y4YD@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD2_k127_1209816_0	1267535.KB906767_gene2550	9.375e-320	986.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HFD2_k127_1209816_10	234267.Acid_7304	1.291e-27	113.0	COG1828@1|root,COG1828@2|Bacteria,3Y5NE@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HFD2_k127_1209816_3	234267.Acid_2439	1.218e-91	308.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_1209816_1	234267.Acid_2438	3.412e-193	611.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD2_k127_1209816_7	1267535.KB906767_gene5066	5.036e-52	188.0	COG0784@1|root,COG0784@2|Bacteria,3Y8JB@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1209816_5	1267535.KB906767_gene2254	1.425e-74	259.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD2_k127_1209816_4	234267.Acid_3194	1.198e-74	254.0	COG1666@1|root,COG1666@2|Bacteria,3Y4I3@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HFD2_k127_1209816_9	234267.Acid_3193	3.535e-39	154.0	COG2199@1|root,COG3706@2|Bacteria,3Y5QC@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_1209816_6	1340493.JNIF01000003_gene1323	1.876e-58	209.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_6,YfiO
HFD2_k127_1214400_3	136993.KB900627_gene392	1.408e-26	121.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1214400_5	313596.RB2501_11502	0.0004277	52.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1HZ2Z@117743|Flavobacteriia	976|Bacteroidetes	QU	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HFD2_k127_1214400_0	189753.AXAS01000013_gene5867	1.504e-133	439.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,3JSJF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HFD2_k127_1214400_2	639030.JHVA01000001_gene1884	2.065e-27	121.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1214400_4	627192.SLG_09880	8.403e-23	108.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2VG0A@28211|Alphaproteobacteria,2KBBC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1214400_1	1267535.KB906767_gene3591	8.694e-96	325.0	COG2333@1|root,COG2333@2|Bacteria,3Y323@57723|Acidobacteria,2JHP4@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1251528_0	234267.Acid_7188	6.935e-231	739.0	COG2844@1|root,COG2844@2|Bacteria,3Y2FJ@57723|Acidobacteria	57723|Acidobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD
HFD2_k127_1251528_2	1267535.KB906767_gene639	2.467e-55	195.0	COG0347@1|root,COG0347@2|Bacteria,3Y4TF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD2_k127_1251528_1	1267535.KB906767_gene640	1.208e-89	299.0	COG0004@1|root,COG0004@2|Bacteria,3Y2VR@57723|Acidobacteria,2JHMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD2_k127_12605_0	420662.Mpe_A0363	1.306e-198	633.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,1KK5N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	PQQ enzyme repeat	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_12605_1	1144305.PMI02_01782	2.293e-59	216.0	COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,2TVDN@28211|Alphaproteobacteria,2K2S7@204457|Sphingomonadales	204457|Sphingomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_12605_2	105422.BBPM01000024_gene3368	1.271e-05	50.0	COG4993@1|root,COG4993@2|Bacteria,2I3R4@201174|Actinobacteria	201174|Actinobacteria	G	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
HFD2_k127_1262036_7	1121938.AUDY01000007_gene2501	2.366e-05	50.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1262036_1	330214.NIDE3686	6.574e-39	149.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	glbN	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_1262036_3	136993.KB900627_gene392	2.278e-31	134.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1262036_5	639030.JHVA01000001_gene1884	1.219e-25	117.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1262036_4	247633.GP2143_17801	2.399e-27	121.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1262036_0	309801.trd_0447	1.854e-89	307.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi,27XXF@189775|Thermomicrobia	189775|Thermomicrobia	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_1262036_2	234267.Acid_7379	4.871e-32	142.0	2A08G@1|root,33ENC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1262036_6	113395.AXAI01000010_gene2302	1.62e-16	81.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3JRZ3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PQQ-like domain	exaA	-	1.1.2.8,1.1.5.11	ko:K00114,ko:K20937	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_1265307_0	1536770.R50345_05650	2.635e-29	134.0	COG0457@1|root,COG0457@2|Bacteria,1TPP8@1239|Firmicutes,4HCXY@91061|Bacilli,26S7B@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HFD2_k127_1265307_1	204669.Acid345_0760	1.066e-08	61.0	COG2010@1|root,COG2010@2|Bacteria,3Y5MU@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_1269309_1	234267.Acid_4768	1.83e-60	211.0	COG0510@1|root,COG0510@2|Bacteria,3Y88W@57723|Acidobacteria	57723|Acidobacteria	M	Choline/ethanolamine kinase	-	-	-	ko:K09965	-	-	-	-	ko00000	-	-	-	APH
HFD2_k127_1269309_2	404589.Anae109_1654	7.458e-60	210.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,42SN0@68525|delta/epsilon subdivisions,2WPY6@28221|Deltaproteobacteria,2Z0UJ@29|Myxococcales	28221|Deltaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
HFD2_k127_1269309_0	1385935.N836_34480	3.922e-62	220.0	COG2197@1|root,COG2197@2|Bacteria,1G5A4@1117|Cyanobacteria,1H7R3@1150|Oscillatoriales	1117|Cyanobacteria	KT	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1269309_3	1403819.BATR01000047_gene1358	2.805e-40	164.0	COG3829@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4585@2|Bacteria,46SBM@74201|Verrucomicrobia,2IV76@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_3,PAS_4
HFD2_k127_1273206_2	1192759.AKIB01000027_gene2114	4.881e-58	206.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,2KA1H@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_1273206_3	886293.Sinac_1155	1.652e-55	212.0	COG0666@1|root,COG0666@2|Bacteria,2J1F8@203682|Planctomycetes	203682|Planctomycetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD2_k127_1273206_1	886293.Sinac_1154	7.867e-116	387.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_1273206_0	234267.Acid_5827	3.129e-168	540.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_128269_0	234267.Acid_7568	0.0	1381.0	COG0841@1|root,COG0841@2|Bacteria,3Y2RX@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_128269_1	234267.Acid_7569	2.091e-104	351.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_128269_2	234267.Acid_2003	4.725e-74	257.0	COG0457@1|root,COG0457@2|Bacteria,3Y5A8@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HFD2_k127_128269_4	234267.Acid_2002	3.325e-53	206.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_2002|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_128269_5	269799.Gmet_1932	3.81e-21	106.0	COG0457@1|root,COG0457@2|Bacteria,1QXNU@1224|Proteobacteria,43C4R@68525|delta/epsilon subdivisions,2X7F5@28221|Deltaproteobacteria,43SFM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_2,TPR_8
HFD2_k127_128269_3	1267535.KB906767_gene5452	9.487e-54	193.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N,SLH
HFD2_k127_128269_7	861299.J421_5667	2.969e-07	55.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DHOR
HFD2_k127_1287596_10	1340493.JNIF01000003_gene4681	1.572e-151	488.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1287596_8	234267.Acid_4125	1.253e-152	494.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1287596_17	1340493.JNIF01000003_gene2194	7.11e-47	171.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_1287596_3	1267533.KB906736_gene1146	3.642e-258	822.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1287596_4	1267535.KB906767_gene2769	1.274e-228	736.0	COG0577@1|root,COG0577@2|Bacteria,3Y6DT@57723|Acidobacteria,2JKDM@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1287596_2	234267.Acid_0587	7.075e-281	881.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,3Y4RT@57723|Acidobacteria	57723|Acidobacteria	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
HFD2_k127_1287596_16	234267.Acid_1266	2.467e-75	258.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_1287596_20	234267.Acid_1266	1.193e-21	96.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_1287596_13	234267.Acid_1265	3.273e-133	437.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HFD2_k127_1287596_7	1267535.KB906767_gene2367	2.321e-153	491.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_1287596_6	234267.Acid_1263	3.3e-163	521.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_1287596_18	234267.Acid_1262	5.784e-37	148.0	COG0775@1|root,COG0775@2|Bacteria,3Y5BZ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphorylase superfamily	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_1287596_12	1267535.KB906767_gene2370	1.904e-141	456.0	COG0451@1|root,COG0451@2|Bacteria,3Y41S@57723|Acidobacteria,2JIV2@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM hopanoid-associated sugar epimerase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HFD2_k127_1287596_5	1340493.JNIF01000003_gene3883	5.355e-172	556.0	COG0535@1|root,COG0535@2|Bacteria,3Y2JV@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
HFD2_k127_1287596_1	1267535.KB906767_gene2371	1.884e-288	900.0	COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria,2JIJP@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HFD2_k127_1287596_11	1267535.KB906767_gene2372	2.429e-148	478.0	COG0761@1|root,COG0761@2|Bacteria,3Y40M@57723|Acidobacteria,2JIXC@204432|Acidobacteriia	204432|Acidobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD2_k127_1287596_9	234267.Acid_6893	1.938e-152	485.0	COG1388@1|root,COG1388@2|Bacteria,3Y4VG@57723|Acidobacteria	57723|Acidobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD2_k127_1287596_15	1340493.JNIF01000003_gene3432	2.12e-112	406.0	COG1629@1|root,COG1629@2|Bacteria,3Y765@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_1287596_0	1267535.KB906767_gene448	2.417e-292	904.0	COG0595@1|root,COG0595@2|Bacteria,3Y2NH@57723|Acidobacteria,2JI53@204432|Acidobacteriia	204432|Acidobacteriia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HFD2_k127_1287596_14	1267535.KB906767_gene39	2.416e-123	399.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1314916_7	234267.Acid_0053	4.18e-07	53.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_1314916_6	555793.WSK_4047	5.182e-26	119.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1314916_4	1340493.JNIF01000003_gene1391	2.417e-82	289.0	COG0515@1|root,COG0515@2|Bacteria	1340493.JNIF01000003_gene1391|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1314916_1	234267.Acid_0052	8.706e-196	626.0	COG0527@1|root,COG0527@2|Bacteria,3Y62M@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_1314916_5	234267.Acid_0051	2.046e-71	247.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD2_k127_1314916_2	234267.Acid_5313	1.397e-122	407.0	COG0845@1|root,COG0845@2|Bacteria,3Y760@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_1314916_0	234267.Acid_5314	0.0	1155.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_1314916_3	234267.Acid_5315	1.638e-96	318.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_1318256_1	1267535.KB906767_gene4613	2.081e-71	264.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_1318256_3	65093.PCC7418_2487	2.073e-16	93.0	COG1565@1|root,COG1565@2|Bacteria,1G16Z@1117|Cyanobacteria	1117|Cyanobacteria	S	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD2_k127_1318256_2	204669.Acid345_1176	2.477e-35	142.0	COG0461@1|root,COG0461@2|Bacteria,3Y4ID@57723|Acidobacteria,2JJDT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD2_k127_1318256_0	1267535.KB906767_gene275	4.222e-102	342.0	COG0657@1|root,COG0657@2|Bacteria,3Y44Z@57723|Acidobacteria,2JJYN@204432|Acidobacteriia	204432|Acidobacteriia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD2_k127_1318256_4	937777.Deipe_1020	2.095e-06	56.0	COG3404@1|root,COG3404@2|Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	-	-	2.1.2.5,4.3.1.4	ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD_C
HFD2_k127_1318256_5	715451.ambt_12010	1.869e-05	55.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1326738_1	926566.Terro_1436	4.294e-22	104.0	COG3577@1|root,COG3577@2|Bacteria,3Y7T8@57723|Acidobacteria,2JN2U@204432|Acidobacteriia	204432|Acidobacteriia	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1326738_2	234267.Acid_6124	8.138e-11	63.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,PRiA4_ORF3
HFD2_k127_1326738_0	234267.Acid_3489	5.874e-67	232.0	COG0745@1|root,COG0745@2|Bacteria,3Y2I8@57723|Acidobacteria	57723|Acidobacteria	KT	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
HFD2_k127_1327536_4	1121121.KB894333_gene4598	0.0004482	48.0	2ED1A@1|root,336Y8@2|Bacteria,1VNP3@1239|Firmicutes,4HRCX@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1327536_2	234267.Acid_0348	2.468e-125	415.0	COG0534@1|root,COG0534@2|Bacteria,3Y2U1@57723|Acidobacteria	57723|Acidobacteria	V	efflux protein, MATE family	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HFD2_k127_1327536_0	234267.Acid_1088	4.728e-195	617.0	COG0486@1|root,COG0486@2|Bacteria,3Y3QJ@57723|Acidobacteria	57723|Acidobacteria	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HFD2_k127_1327536_3	1267535.KB906767_gene3478	1.776e-61	218.0	COG1847@1|root,COG1847@2|Bacteria,3Y52C@57723|Acidobacteria,2JJF9@204432|Acidobacteriia	204432|Acidobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	R3H
HFD2_k127_1327536_1	1267535.KB906767_gene3477	2.706e-142	464.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria,2JI2B@204432|Acidobacteriia	204432|Acidobacteriia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HFD2_k127_1338723_0	1267535.KB906767_gene913	2.769e-262	825.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD2_k127_1338723_1	234267.Acid_1914	2.837e-196	619.0	COG0304@1|root,COG0304@2|Bacteria,3Y43C@57723|Acidobacteria	57723|Acidobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_1338723_6	1340493.JNIF01000003_gene3642	5.603e-110	364.0	COG0489@1|root,COG0489@2|Bacteria,3Y66Z@57723|Acidobacteria	57723|Acidobacteria	D	AAA domain	-	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD2_k127_1338723_5	1267535.KB906767_gene2642	5.552e-125	420.0	COG3206@1|root,COG3206@2|Bacteria,3Y6PS@57723|Acidobacteria	57723|Acidobacteria	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1338723_11	1267535.KB906767_gene2643	9.103e-42	162.0	COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_1338723_9	234267.Acid_2578	9.484e-52	186.0	COG2947@1|root,COG2947@2|Bacteria,3Y54W@57723|Acidobacteria	57723|Acidobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD2_k127_1338723_4	1267535.KB906767_gene3233	3.902e-139	452.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria,2JINN@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase, M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_1338723_3	1267535.KB906767_gene3235	2.575e-149	490.0	COG0265@1|root,COG0265@2|Bacteria,3Y2SD@57723|Acidobacteria,2JI16@204432|Acidobacteriia	204432|Acidobacteriia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_1338723_12	1267535.KB906767_gene3232	2.014e-20	98.0	COG3409@1|root,COG3409@2|Bacteria,3Y5JQ@57723|Acidobacteria	57723|Acidobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD2_k127_1338723_10	234267.Acid_5030	6.125e-50	183.0	COG2353@1|root,COG2353@2|Bacteria,3Y4PV@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_1338723_2	1340493.JNIF01000003_gene2437	4.492e-192	606.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD2_k127_1338723_7	234267.Acid_1600	7.596e-80	287.0	COG1450@1|root,COG1450@2|Bacteria,3Y6Z6@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial type II and III secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
HFD2_k127_1338723_8	234267.Acid_2012	7.724e-77	265.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	sumf2	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_14,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_134734_5	234267.Acid_6349	3.69e-14	72.0	COG4219@1|root,COG4219@2|Bacteria,3Y5D9@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_134734_1	234267.Acid_6425	1.702e-152	487.0	COG2896@1|root,COG2896@2|Bacteria,3Y30D@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HFD2_k127_134734_3	234267.Acid_6238	2.501e-41	161.0	COG1238@1|root,COG1238@2|Bacteria,3Y8FS@57723|Acidobacteria	57723|Acidobacteria	I	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_134734_0	429009.Adeg_1094	2.292e-205	658.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,42F6C@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD2_k127_134734_2	1267535.KB906767_gene2508	6.752e-77	271.0	COG1597@1|root,COG1597@2|Bacteria,3Y58A@57723|Acidobacteria,2JP23@204432|Acidobacteriia	204432|Acidobacteriia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD2_k127_134734_6	1449063.JMLS01000030_gene409	2.64e-11	75.0	COG1988@1|root,COG1988@2|Bacteria,1TQFC@1239|Firmicutes,4H9PU@91061|Bacilli,26TKS@186822|Paenibacillaceae	91061|Bacilli	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
HFD2_k127_134734_4	1340493.JNIF01000004_gene626	1.257e-18	87.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GV@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_1368477_0	1449126.JQKL01000009_gene318	2.725e-180	592.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD2_k127_1373157_1	627192.SLG_04410	2.114e-153	500.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_1373157_0	627192.SLG_04410	1.721e-203	651.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_1373157_2	234267.Acid_6820	1.672e-35	139.0	COG2202@1|root,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_4,PAS_9,STAS
HFD2_k127_1373157_3	639030.JHVA01000001_gene276	2.636e-06	53.0	COG1999@1|root,COG1999@2|Bacteria,3Y5CC@57723|Acidobacteria,2JHX0@204432|Acidobacteriia	204432|Acidobacteriia	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HFD2_k127_137681_0	644966.Tmar_0341	1.707e-95	327.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia	186801|Clostridia	L	integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Mu-transpos_C,rve
HFD2_k127_137681_1	867903.ThesuDRAFT_00893	4.353e-94	316.0	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia	186801|Clostridia	L	IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HFD2_k127_137681_2	743299.Acife_0694	1.71e-05	48.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,2NBW1@225057|Acidithiobacillales	1236|Gammaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_1382307_2	1267535.KB906767_gene5437	3.615e-129	423.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria,2JIJ7@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase D, 3'-phosphoesterase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_1382307_3	234267.Acid_7842	1.295e-111	370.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria	57723|Acidobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD2_k127_1382307_11	555779.Dthio_PD1759	5.878e-25	104.0	COG1724@1|root,COG1724@2|Bacteria,1NA6Q@1224|Proteobacteria	1224|Proteobacteria	N	PFAM YcfA family protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_1382307_9	671143.DAMO_0594	2.062e-29	118.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_1382307_4	234267.Acid_0449	2.03e-87	294.0	COG1801@1|root,COG1801@2|Bacteria,3Y2F1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_1382307_0	234267.Acid_0993	1.099e-264	829.0	COG1132@1|root,COG1132@2|Bacteria,3Y2XY@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_1382307_8	234267.Acid_6742	5.892e-31	128.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
HFD2_k127_1382307_7	234267.Acid_1287	2.422e-38	153.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_1382307_6	1267535.KB906767_gene4537	2.348e-71	243.0	COG0328@1|root,COG1057@1|root,COG0328@2|Bacteria,COG1057@2|Bacteria,3Y5D2@57723|Acidobacteria,2JJNT@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_1382307_1	234267.Acid_6679	1.09e-163	520.0	COG0042@1|root,COG0042@2|Bacteria,3Y3XE@57723|Acidobacteria	57723|Acidobacteria	J	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HFD2_k127_1382307_5	234267.Acid_3725	4.464e-76	279.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1382307_10	1340493.JNIF01000003_gene4065	2.643e-25	116.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria	57723|Acidobacteria	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HFD2_k127_1433361_1	234267.Acid_2669	1.707e-26	109.0	COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria	57723|Acidobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HFD2_k127_1433361_0	1121403.AUCV01000005_gene214	1.239e-86	291.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,42R0Z@68525|delta/epsilon subdivisions,2WMNE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM NAD(P)H dehydrogenase (quinone)	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
HFD2_k127_1433361_2	857087.Metme_0124	6.523e-10	62.0	COG2251@1|root,COG3464@1|root,COG2251@2|Bacteria,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,RNase_H_2,zf-IS66
HFD2_k127_1433361_3	886293.Sinac_2556	1.359e-08	61.0	COG0526@1|root,COG1331@1|root,COG0526@2|Bacteria,COG1331@2|Bacteria,2J28Y@203682|Planctomycetes	203682|Planctomycetes	CO	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_146127_1	1382359.JIAL01000001_gene2497	2.005e-06	58.0	COG1629@1|root,COG1629@2|Bacteria,3Y37P@57723|Acidobacteria,2JM6C@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_146127_0	247633.GP2143_17796	2.088e-60	226.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1468332_0	1047013.AQSP01000125_gene2637	1.252e-67	243.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
HFD2_k127_1468332_3	926569.ANT_07060	2.337e-08	61.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HFD2_k127_1468332_1	1267534.KB906755_gene4691	3.6e-67	240.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_1468332_2	1267533.KB906733_gene2989	5.506e-47	175.0	COG0642@1|root,COG2205@2|Bacteria,3Y2M7@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_1493093_3	234267.Acid_2367	3.485e-20	93.0	COG3842@1|root,COG3842@2|Bacteria,3Y4Q4@57723|Acidobacteria	57723|Acidobacteria	P	TOBE domain	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HFD2_k127_1493093_0	1340493.JNIF01000003_gene2566	1.028e-112	371.0	COG1176@1|root,COG1176@2|Bacteria	2|Bacteria	P	putrescine transport	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HFD2_k127_1493093_1	1267535.KB906767_gene3306	4.678e-98	326.0	COG1177@1|root,COG1177@2|Bacteria,3Y57S@57723|Acidobacteria,2JN4V@204432|Acidobacteriia	204432|Acidobacteriia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HFD2_k127_1493093_2	234267.Acid_2370	4.271e-76	270.0	COG0687@1|root,COG0687@2|Bacteria,3Y5JD@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
HFD2_k127_1531982_0	204669.Acid345_3443	3.415e-234	734.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_153713_1	1340493.JNIF01000003_gene3558	3.968e-69	244.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HFD2_k127_153713_0	234267.Acid_5749	7.552e-81	282.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1564876_0	234267.Acid_0508	1.486e-87	296.0	COG0497@1|root,COG0497@2|Bacteria,3Y2J4@57723|Acidobacteria	57723|Acidobacteria	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HFD2_k127_1564876_1	1267535.KB906767_gene576	3.019e-69	244.0	COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria,2JIN7@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HFD2_k127_1564876_2	1267535.KB906767_gene575	7.045e-34	135.0	COG0848@1|root,COG0848@2|Bacteria,3Y4QV@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD2_k127_1564876_3	1340493.JNIF01000003_gene3053	3.702e-20	99.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HFD2_k127_1598395_0	234267.Acid_2365	2.673e-273	857.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD2_k127_1598395_2	234267.Acid_2365	8.964e-121	421.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD2_k127_1598395_1	1340493.JNIF01000004_gene730	4.606e-124	409.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD2_k127_1598395_3	1340493.JNIF01000004_gene731	2.295e-78	276.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
HFD2_k127_1650791_0	234267.Acid_1851	1.347e-152	500.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
HFD2_k127_1650791_1	123214.PERMA_1491	2.825e-76	265.0	COG2204@1|root,COG2204@2|Bacteria,2G3T9@200783|Aquificae	200783|Aquificae	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_167030_2	1267535.KB906767_gene3177	1.579e-79	266.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HFD2_k127_167030_1	886293.Sinac_0122	4.502e-123	409.0	COG2271@1|root,COG2271@2|Bacteria,2IXXA@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_167030_0	1267535.KB906767_gene2807	1.364e-136	478.0	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_167030_4	551789.ATVJ01000001_gene1039	4.702e-35	141.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_167030_5	450851.PHZ_c3077	8.543e-34	145.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,2UKQP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_167030_3	247633.GP2143_17791	1.274e-44	165.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1711259_12	1120999.JONM01000006_gene2348	2.257e-06	59.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KPC3@206351|Neisseriales	206351|Neisseriales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_1711259_0	926566.Terro_0943	5.939e-159	540.0	COG1629@1|root,COG4771@2|Bacteria	926566.Terro_0943|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1711259_10	866895.HBHAL_1710	6.685e-14	83.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,3NEGE@45667|Halobacillus	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD2_k127_1711259_7	935840.JAEQ01000004_gene608	2.683e-57	208.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria,43IPN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_1711259_5	1037409.BJ6T_34470	1.022e-63	227.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3JQW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	MA20_34180	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
HFD2_k127_1711259_9	1906.SFRA_29675	3.918e-31	130.0	COG0662@1|root,COG0662@2|Bacteria,2GPB5@201174|Actinobacteria	201174|Actinobacteria	G	WxcM-like, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FdtA
HFD2_k127_1711259_1	1121918.ARWE01000001_gene1829	4.522e-139	453.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,43UJU@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	DegT/DnrJ/EryC1/StrS aminotransferase family	fdtB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_1711259_8	56110.Oscil6304_2270	6.728e-46	179.0	COG1216@1|root,COG1216@2|Bacteria,1G2W7@1117|Cyanobacteria,1H7WE@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1711259_3	234267.Acid_5602	8.45e-139	445.0	COG0598@1|root,COG0598@2|Bacteria,3Y4BT@57723|Acidobacteria	57723|Acidobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD2_k127_1711259_2	686340.Metal_1949	7.428e-139	482.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales	135618|Methylococcales	KT	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HFD2_k127_1711259_4	234267.Acid_2557	1.205e-102	338.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_1774292_1	204669.Acid345_1764	7.25e-42	174.0	COG5373@1|root,COG5373@2|Bacteria,3Y2GV@57723|Acidobacteria,2JIMY@204432|Acidobacteriia	204432|Acidobacteriia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HFD2_k127_1774292_3	234267.Acid_1841	1.469e-24	108.0	29CGV@1|root,2ZZF9@2|Bacteria,3Y4JX@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HFD2_k127_1774292_0	234267.Acid_1840	3.316e-112	368.0	COG1235@1|root,COG1235@2|Bacteria,3Y40S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HFD2_k127_1774292_2	1267535.KB906767_gene565	2.556e-29	121.0	COG0196@1|root,COG0196@2|Bacteria,3Y34N@57723|Acidobacteria,2JIGD@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HFD2_k127_1779014_3	1267535.KB906767_gene4340	4.759e-50	181.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HFD2_k127_1779014_1	234267.Acid_5561	2.492e-181	581.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HFD2_k127_1779014_2	378806.STAUR_7358	9.036e-68	232.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_1779014_0	234267.Acid_5823	9.032e-207	652.0	COG1680@1|root,COG1680@2|Bacteria,3Y6F4@57723|Acidobacteria	57723|Acidobacteria	V	PFAM Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
HFD2_k127_1779014_4	43989.cce_1707	1.084e-05	52.0	COG0845@1|root,COG0845@2|Bacteria,1G8SJ@1117|Cyanobacteria,3KJFQ@43988|Cyanothece	1117|Cyanobacteria	M	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
HFD2_k127_178085_1	627192.SLG_04410	3.7e-172	554.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_178085_0	627192.SLG_04410	5.773e-191	616.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_178085_3	1173029.JH980292_gene2834	3.498e-21	94.0	COG1598@1|root,COG1598@2|Bacteria,1G7N4@1117|Cyanobacteria,1HDCI@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_178085_4	765912.Thimo_2577	1.475e-19	90.0	COG1724@1|root,COG1724@2|Bacteria,1NB5I@1224|Proteobacteria,1STWS@1236|Gammaproteobacteria,1X1U5@135613|Chromatiales	135613|Chromatiales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_178085_5	639030.JHVA01000001_gene276	1.267e-07	58.0	COG1999@1|root,COG1999@2|Bacteria,3Y5CC@57723|Acidobacteria,2JHX0@204432|Acidobacteriia	204432|Acidobacteriia	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HFD2_k127_178085_2	1340493.JNIF01000004_gene855	2.592e-29	127.0	COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_1790478_1	234267.Acid_4199	1.2e-57	208.0	COG1595@1|root,COG1595@2|Bacteria,3Y6TU@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1790478_0	1267535.KB906767_gene2916	9.738e-202	633.0	COG0277@1|root,COG0277@2|Bacteria,3Y36Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HFD2_k127_1794928_7	1107311.Q767_03905	9.194e-16	83.0	2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,1I1C4@117743|Flavobacteriia,2NVED@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD2_k127_1794928_0	234267.Acid_6567	0.0	1088.0	COG0826@1|root,COG0826@2|Bacteria,3Y7M5@57723|Acidobacteria	57723|Acidobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HFD2_k127_1794928_4	196490.AUEZ01000036_gene6081	4.531e-74	256.0	COG3828@1|root,COG3828@2|Bacteria,1R5XA@1224|Proteobacteria,2U51F@28211|Alphaproteobacteria,3K5VQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	GSDH,ThuA
HFD2_k127_1794928_6	1123508.JH636440_gene2420	6.021e-26	111.0	COG2350@1|root,COG2350@2|Bacteria,2J3W7@203682|Planctomycetes	203682|Planctomycetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_1794928_1	234267.Acid_1170	1.537e-103	343.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_1794928_5	1286171.EAL2_808p03370	2.339e-33	146.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,25ZF5@186806|Eubacteriaceae	186801|Clostridia	O	Subtilase family	isp	-	3.4.21.62	ko:K01342,ko:K13275	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
HFD2_k127_1794928_2	1267535.KB906767_gene347	2.011e-98	330.0	COG2159@1|root,COG2159@2|Bacteria,3Y6P0@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD2_k127_1794928_3	234267.Acid_2450	1.837e-95	319.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HFD2_k127_1813037_2	234267.Acid_6772	6.637e-95	314.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_1813037_1	234267.Acid_1234	3.213e-120	396.0	COG1609@1|root,COG1609@2|Bacteria,3Y49N@57723|Acidobacteria	57723|Acidobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD2_k127_1813037_8	1335760.ASTG01000003_gene1749	8.487e-10	66.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria,2UJHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1813037_7	555793.WSK_3533	1.448e-17	94.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1813037_4	1345695.CLSA_c36070	2.11e-58	214.0	COG0491@1|root,COG0491@2|Bacteria,1UZ50@1239|Firmicutes,24A1I@186801|Clostridia,36HBK@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_1813037_5	1279017.AQYJ01000028_gene2525	1.329e-47	193.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1813037_3	1242864.D187_005547	4.68e-84	288.0	COG0583@1|root,COG0583@2|Bacteria,1PEF2@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1813037_0	234267.Acid_0260	2.215e-263	823.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Tannase
HFD2_k127_1813037_6	313628.LNTAR_09736	1.484e-39	159.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9
HFD2_k127_1813037_9	1121097.JCM15093_1912	2.395e-06	51.0	COG0657@1|root,COG0657@2|Bacteria,4NIQ0@976|Bacteroidetes,2FR99@200643|Bacteroidia,4APVM@815|Bacteroidaceae	976|Bacteroidetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
HFD2_k127_1853520_6	234267.Acid_6509	9.629e-51	188.0	2EKZZ@1|root,33EPG@2|Bacteria,3Y5U9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Lipase_GDSL_2
HFD2_k127_1853520_12	234267.Acid_4217	0.0003521	45.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
HFD2_k127_1853520_10	1340493.JNIF01000004_gene761	2.852e-20	96.0	COG1858@1|root,COG1858@2|Bacteria,3Y46D@57723|Acidobacteria	57723|Acidobacteria	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD2_k127_1853520_0	234267.Acid_2745	1.186e-198	624.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD2_k127_1853520_4	234267.Acid_2746	1.039e-72	248.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria	57723|Acidobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD2_k127_1853520_3	234267.Acid_2747	1.828e-116	382.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria	57723|Acidobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD2_k127_1853520_2	234267.Acid_2748	1.334e-143	466.0	COG1364@1|root,COG1364@2|Bacteria,3Y2PH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD2_k127_1853520_1	1267535.KB906767_gene1154	2.621e-189	599.0	COG0460@1|root,COG0460@2|Bacteria,3Y2VY@57723|Acidobacteria,2JHYQ@204432|Acidobacteriia	204432|Acidobacteriia	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_1853520_7	234267.Acid_2867	3.109e-45	170.0	2EIAS@1|root,33C26@2|Bacteria,3Y5X7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1853520_9	234267.Acid_0533	2.276e-21	97.0	290CR@1|root,2ZN27@2|Bacteria,3Y8Z2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1853520_8	234267.Acid_5511	1.063e-33	131.0	COG2065@1|root,COG2065@2|Bacteria,3Y2S1@57723|Acidobacteria	57723|Acidobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD2_k127_1871276_0	234267.Acid_5363	2.932e-149	482.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HFD2_k127_1871276_5	234267.Acid_5362	8.635e-43	166.0	COG2976@1|root,COG2976@2|Bacteria,3Y9AW@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HFD2_k127_1871276_2	234267.Acid_7901	1.941e-63	225.0	COG2197@1|root,COG2197@2|Bacteria,3Y8CY@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1871276_3	234267.Acid_0107	1.091e-50	181.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria	57723|Acidobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD2_k127_1871276_4	1267535.KB906767_gene3895	7.124e-49	179.0	COG2172@1|root,COG2172@2|Bacteria,3Y4TY@57723|Acidobacteria,2JJGJ@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD2_k127_1871276_1	1185876.BN8_04225	2.114e-135	440.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_1886630_3	1267535.KB906767_gene2745	7.435e-80	272.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria	57723|Acidobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1886630_5	234267.Acid_4171	7.476e-73	258.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1886630_2	234267.Acid_4171	4.571e-85	296.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1886630_1	234267.Acid_4171	5.288e-119	391.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1886630_6	1267535.KB906767_gene571	1.137e-40	162.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria,2JIES@204432|Acidobacteriia	204432|Acidobacteriia	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HFD2_k127_1886630_4	1267535.KB906767_gene572	4.61e-73	255.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria,2JI9Y@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD2_k127_1886630_0	1340493.JNIF01000003_gene3054	3.902e-138	452.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD2_k127_1886630_7	1340493.JNIF01000003_gene3053	6.451e-18	85.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HFD2_k127_1900810_4	1340493.JNIF01000003_gene4413	1.079e-35	138.0	COG3267@1|root,COG3267@2|Bacteria,3Y6P4@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD2_k127_1900810_2	234267.Acid_0549	1.276e-55	211.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_1900810_1	234267.Acid_0817	2.26e-77	271.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HFD2_k127_1900810_0	234267.Acid_0345	3.489e-110	363.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HFD2_k127_1900810_3	1340493.JNIF01000004_gene702	1.725e-46	173.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria	57723|Acidobacteria	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_1927178_7	1267535.KB906767_gene5360	7.615e-76	262.0	COG3622@1|root,COG3622@2|Bacteria,3Y6XP@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_1927178_10	234267.Acid_3047	5.131e-05	46.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD2_k127_1927178_8	697282.Mettu_2234	1.021e-68	253.0	COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria,1SHXM@1236|Gammaproteobacteria,1XEX1@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1927178_6	1267535.KB906767_gene3324	2.857e-89	306.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD2_k127_1927178_3	1267535.KB906767_gene3324	3.106e-115	381.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD2_k127_1927178_9	1267535.KB906767_gene3323	2.372e-22	104.0	COG1826@1|root,COG1826@2|Bacteria,3Y5TY@57723|Acidobacteria	57723|Acidobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_1927178_5	1459636.NTE_00231	1.352e-92	317.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_1927178_11	596152.DesU5LDRAFT_0921	0.000888	49.0	COG0457@1|root,COG2227@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,1MVMG@1224|Proteobacteria,42WHV@68525|delta/epsilon subdivisions,2WSI4@28221|Deltaproteobacteria,2MA6Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPR_1,TPR_16,TPR_2,TPR_4,TPR_8
HFD2_k127_1927178_2	234267.Acid_6332	1.962e-116	387.0	COG1566@1|root,COG1566@2|Bacteria,3Y2GY@57723|Acidobacteria	57723|Acidobacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1927178_4	1382306.JNIM01000001_gene3272	3.865e-94	322.0	COG0477@1|root,COG0477@2|Bacteria,2G5YG@200795|Chloroflexi	200795|Chloroflexi	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_1927178_1	639030.JHVA01000001_gene1568	1.694e-134	436.0	COG5042@1|root,COG5042@2|Bacteria,3Y2QK@57723|Acidobacteria,2JIUB@204432|Acidobacteriia	204432|Acidobacteriia	F	PFAM purine nucleoside permease	-	-	-	-	-	-	-	-	-	-	-	-	NUP
HFD2_k127_1927178_0	1120983.KB894571_gene2265	6.898e-209	661.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_1936336_7	234267.Acid_5704	4.135e-46	169.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
HFD2_k127_1936336_0	930169.B5T_00528	5.614e-170	550.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1XHGR@135619|Oceanospirillales	135619|Oceanospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_1936336_1	1267535.KB906767_gene1411	8.056e-158	513.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_1936336_6	1173028.ANKO01000112_gene4871	1.349e-59	215.0	COG1216@1|root,COG1216@2|Bacteria,1G2A7@1117|Cyanobacteria,1H9SV@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
HFD2_k127_1936336_9	1173028.ANKO01000112_gene4868	3.978e-26	113.0	2E7MG@1|root,3323C@2|Bacteria,1GCRI@1117|Cyanobacteria,1HFKH@1150|Oscillatoriales	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HFD2_k127_1936336_4	1173022.Cri9333_4868	1.782e-88	304.0	COG1493@1|root,COG1493@2|Bacteria,1GD1X@1117|Cyanobacteria,1HE2B@1150|Oscillatoriales	1117|Cyanobacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1936336_3	1340493.JNIF01000003_gene4740	1.528e-111	376.0	COG1216@1|root,COG1216@2|Bacteria,3Y7UY@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1936336_2	1173028.ANKO01000112_gene4873	2.95e-134	448.0	COG1132@1|root,COG1132@2|Bacteria,1G185@1117|Cyanobacteria,1H7WN@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_1936336_5	1173028.ANKO01000112_gene4874	1.689e-70	256.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HFD2_k127_1936336_8	1415630.U771_26125	2.167e-27	120.0	COG3000@1|root,COG3000@2|Bacteria,1R763@1224|Proteobacteria,1S0C8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_19455_2	1267535.KB906767_gene4718	4.275e-52	186.0	COG0525@1|root,COG0525@2|Bacteria,3Y2JY@57723|Acidobacteria,2JIBS@204432|Acidobacteriia	204432|Acidobacteriia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HFD2_k127_19455_1	234267.Acid_2432	4.883e-59	209.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_19455_0	671143.DAMO_1780	1.288e-122	417.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_1949290_4	56780.SYN_01995	7.755e-51	186.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1949290_3	671143.DAMO_3154	9.765e-95	316.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1949290_1	671143.DAMO_3155	8.464e-110	374.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HFD2_k127_1949290_2	1267535.KB906767_gene975	2.153e-96	321.0	COG0101@1|root,COG0101@2|Bacteria,3Y2MS@57723|Acidobacteria,2JIWS@204432|Acidobacteriia	204432|Acidobacteriia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD2_k127_1949290_0	251221.35211765	3.96e-133	454.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1949290_5	886293.Sinac_6412	1.072e-29	124.0	COG0520@1|root,COG0520@2|Bacteria,2IXCD@203682|Planctomycetes	203682|Planctomycetes	E	selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_1952423_6	234267.Acid_0113	7.773e-136	435.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HFD2_k127_1952423_7	234267.Acid_0112	1.701e-79	269.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD2_k127_1952423_3	234267.Acid_0111	2.228e-203	639.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
HFD2_k127_1952423_9	1267535.KB906767_gene4280	8.541e-54	198.0	COG0852@1|root,COG0852@2|Bacteria,3Y4IQ@57723|Acidobacteria,2JJCT@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_1952423_10	1340493.JNIF01000003_gene1650	2.126e-50	182.0	COG0838@1|root,COG0838@2|Bacteria,3Y5CV@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD2_k127_1952423_12	1122613.ATUP01000001_gene234	5.877e-16	80.0	COG2022@1|root,COG2022@2|Bacteria,1QYPA@1224|Proteobacteria,2TXU5@28211|Alphaproteobacteria,440TJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
HFD2_k127_1952423_8	1267535.KB906767_gene4277	3.137e-68	236.0	COG0789@1|root,COG0789@2|Bacteria,3Y5EZ@57723|Acidobacteria,2JN9T@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_1952423_2	1340493.JNIF01000003_gene2530	2.792e-212	672.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HFD2_k127_1952423_1	234267.Acid_6467	1.159e-237	747.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3Y3VV@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HFD2_k127_1952423_11	627192.SLG_30730	1.149e-40	156.0	COG4922@1|root,COG4922@2|Bacteria,1RJ34@1224|Proteobacteria,2UT8H@28211|Alphaproteobacteria,2KBC2@204457|Sphingomonadales	204457|Sphingomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1952423_5	1267535.KB906767_gene3246	6.181e-141	454.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HFD2_k127_1952423_4	1267535.KB906767_gene3245	5.51e-148	475.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HFD2_k127_1952423_0	1340493.JNIF01000004_gene878	1.294e-240	756.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,3Y77C@57723|Acidobacteria	57723|Acidobacteria	G	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Peptidase_C14,TPR_2,WD40
HFD2_k127_19869_3	234267.Acid_1111	1.565e-33	132.0	COG0735@1|root,COG0735@2|Bacteria,3Y7UH@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_19869_1	118163.Ple7327_1876	1.322e-93	313.0	COG2406@1|root,COG2406@2|Bacteria,1G4NT@1117|Cyanobacteria,3VKWE@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the Dps family	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
HFD2_k127_19869_4	306281.AJLK01000100_gene3884	1.231e-28	123.0	COG2146@1|root,COG2146@2|Bacteria,1G9AZ@1117|Cyanobacteria,1JM1Y@1189|Stigonemataceae	1117|Cyanobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HFD2_k127_19869_2	237368.SCABRO_00501	9.53e-42	158.0	COG2154@1|root,COG2154@2|Bacteria,2J0CT@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD2_k127_19869_0	234267.Acid_6650	5.549e-148	480.0	COG0006@1|root,COG0006@2|Bacteria,3Y460@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_2001462_2	1267535.KB906767_gene2425	3.554e-29	124.0	COG1310@1|root,COG1310@2|Bacteria,3Y8K0@57723|Acidobacteria	57723|Acidobacteria	S	metal-dependent protease of the Pad1 Jab1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2001462_1	234267.Acid_7179	9.714e-78	263.0	COG2077@1|root,COG2077@2|Bacteria,3Y5DK@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
HFD2_k127_2001462_0	234267.Acid_7180	8.747e-101	338.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HFD2_k127_2020302_2	234267.Acid_6772	5.795e-187	592.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_2020302_1	234267.Acid_4306	9.227e-229	718.0	COG2960@1|root,COG2960@2|Bacteria,3Y7EA@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_2020302_0	234267.Acid_4307	5.706e-303	963.0	COG0551@1|root,COG0551@2|Bacteria,3Y7FR@57723|Acidobacteria	57723|Acidobacteria	L	Protein of unknown function (DUF1595)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD2_k127_2020302_5	234267.Acid_4308	2.478e-65	255.0	COG1957@1|root,COG1957@2|Bacteria	2|Bacteria	F	ribosylpyrimidine nucleosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,IU_nuc_hydro
HFD2_k127_2020302_4	1128421.JAGA01000002_gene974	1.243e-66	233.0	COG0637@1|root,COG0637@2|Bacteria,2NPXK@2323|unclassified Bacteria	2|Bacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_2020302_3	497964.CfE428DRAFT_0590	1.109e-89	304.0	COG1012@1|root,COG1012@2|Bacteria,46SIA@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Aldehyde dehydrogenase family	-	-	1.2.1.26	ko:K13877	ko00040,ko00053,map00040,map00053	-	R00264	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD2_k127_2023351_1	1267535.KB906767_gene3213	4.149e-25	113.0	2F9MS@1|root,341XZ@2|Bacteria,3Y8CW@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2023351_0	234267.Acid_0274	2.014e-32	139.0	COG2911@1|root,COG2911@2|Bacteria,3Y8JR@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2023351_2	234267.Acid_0548	2.006e-14	85.0	COG3307@1|root,COG3307@2|Bacteria,3Y88V@57723|Acidobacteria	57723|Acidobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD2_k127_203456_3	765913.ThidrDRAFT_0640	1.753e-16	83.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
HFD2_k127_203456_0	94624.Bpet1409	4.245e-295	920.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_203456_1	94624.Bpet1408	4.94e-48	176.0	COG3415@1|root,COG3415@2|Bacteria,1RKUV@1224|Proteobacteria,2WFVI@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29
HFD2_k127_203456_2	1121877.JQKF01000078_gene2622	2.284e-23	102.0	2EHAG@1|root,33B2C@2|Bacteria,2GY5W@201174|Actinobacteria	201174|Actinobacteria	S	Family of unknown function (DUF5372)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5372
HFD2_k127_203456_4	234267.Acid_1625	1.214e-14	74.0	COG2801@1|root,COG2801@2|Bacteria,3Y6NP@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
HFD2_k127_206331_2	335543.Sfum_3563	4.608e-54	196.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_206331_8	926560.KE387023_gene1226	2.442e-25	117.0	2E363@1|root,32Y5Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_206331_3	1356852.N008_14320	2.61e-51	191.0	COG5429@1|root,COG5429@2|Bacteria,4NNGV@976|Bacteroidetes,47RAT@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HFD2_k127_206331_0	234267.Acid_7331	2.24e-127	415.0	COG0470@1|root,COG0470@2|Bacteria,3Y6V7@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HFD2_k127_206331_6	234267.Acid_0132	5.275e-32	127.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria	57723|Acidobacteria	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
HFD2_k127_206331_4	234267.Acid_2741	1.914e-37	154.0	COG4219@1|root,COG4219@2|Bacteria,3Y35Z@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_206331_9	234267.Acid_0134	5.203e-18	89.0	295WJ@1|root,2ZT7G@2|Bacteria,3Y8RM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_206331_7	234267.Acid_0135	2.367e-27	113.0	COG0457@1|root,COG0457@2|Bacteria,3Y99M@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_206331_1	234267.Acid_1806	3.336e-55	203.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_206922_6	234267.Acid_2032	1.088e-37	145.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_206922_7	1267535.KB906767_gene2621	1.343e-32	134.0	2985T@1|root,2ZVBP@2|Bacteria,3Y971@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_206922_2	234267.Acid_5827	1.046e-259	822.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_206922_5	234267.Acid_1106	2.008e-57	206.0	COG0586@1|root,COG0586@2|Bacteria,3Y7W0@57723|Acidobacteria	57723|Acidobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_206922_1	1267535.KB906767_gene1113	1.013e-276	863.0	COG0370@1|root,COG0370@2|Bacteria,3Y3CZ@57723|Acidobacteria,2JJQ0@204432|Acidobacteriia	204432|Acidobacteriia	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HFD2_k127_206922_8	1267535.KB906767_gene1114	9.184e-25	107.0	COG1918@1|root,COG1918@2|Bacteria,3Y92B@57723|Acidobacteria	57723|Acidobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HFD2_k127_206922_3	794903.OPIT5_28830	4.308e-123	412.0	COG0617@1|root,COG0617@2|Bacteria,46UER@74201|Verrucomicrobia,3K732@414999|Opitutae	414999|Opitutae	J	Polynucleotide adenylyltransferase	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HFD2_k127_206922_0	1340493.JNIF01000004_gene448	1.236e-299	931.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_2074644_4	1267535.KB906767_gene2426	4.815e-57	201.0	COG0696@1|root,COG0696@2|Bacteria,3Y2YH@57723|Acidobacteria,2JIZ0@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HFD2_k127_2074644_5	234267.Acid_5455	4.133e-19	95.0	COG4636@1|root,COG4636@2|Bacteria,3Y7WQ@57723|Acidobacteria	57723|Acidobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_2074644_2	1267535.KB906767_gene4620	6.452e-91	308.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_2074644_3	234267.Acid_6300	6.177e-73	254.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,TehB
HFD2_k127_2074644_1	1340493.JNIF01000003_gene4067	9.908e-111	372.0	COG2227@1|root,COG2227@2|Bacteria,3Y8XU@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_2074644_0	234267.Acid_6302	1.059e-126	413.0	COG1216@1|root,COG1216@2|Bacteria,3Y5FE@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2093945_2	1267535.KB906767_gene480	2.855e-90	301.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_2093945_0	1267535.KB906767_gene4229	0.0	1054.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HFD2_k127_2093945_3	234267.Acid_6678	1.966e-36	147.0	COG2823@1|root,COG2823@2|Bacteria,3Y7ZV@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2093945_1	204669.Acid345_2766	4.422e-149	478.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria,2JIAZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD2_k127_2093945_5	880072.Desac_1838	1.05e-11	78.0	COG5305@1|root,COG5305@2|Bacteria,1NCN4@1224|Proteobacteria,43CS9@68525|delta/epsilon subdivisions,2WT6N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_2093945_4	234267.Acid_1312	3.072e-27	117.0	292F3@1|root,2ZPZC@2|Bacteria,3Y90G@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2103297_3	234267.Acid_6528	2.467e-12	70.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_2103297_0	234267.Acid_5138	7.881e-144	466.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD2_k127_2103297_1	234267.Acid_5233	7.359e-97	321.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MB@57723|Acidobacteria	57723|Acidobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_2108386_1	401053.AciPR4_3363	4.629e-84	310.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_2108386_0	207954.MED92_11834	4.504e-93	326.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XH8V@135619|Oceanospirillales	135619|Oceanospirillales	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_2129836_7	1340493.JNIF01000003_gene1939	3.655e-24	108.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD2_k127_2129836_3	1340493.JNIF01000003_gene1841	1.436e-82	285.0	COG0810@1|root,COG0810@2|Bacteria,3Y3Q0@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_2129836_4	1267535.KB906767_gene10	4.789e-64	226.0	COG1073@1|root,COG1073@2|Bacteria,3Y5MV@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family (UPF0227)	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	UPF0227
HFD2_k127_2129836_5	760568.Desku_2575	6.519e-48	177.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,261VQ@186807|Peptococcaceae	186801|Clostridia	S	Isoleucine patch superfamily enzyme, carbonic anhydrase acetyltransferase	PaaY	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HFD2_k127_2129836_1	1267535.KB906767_gene1020	3.054e-185	589.0	COG0124@1|root,COG0124@2|Bacteria,3Y3IY@57723|Acidobacteria,2JIRJ@204432|Acidobacteriia	204432|Acidobacteriia	J	synthetase, class II (G H P	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HFD2_k127_2129836_0	1267535.KB906767_gene1021	1.515e-313	967.0	COG0173@1|root,COG0173@2|Bacteria,3Y3SP@57723|Acidobacteria,2JIRC@204432|Acidobacteriia	204432|Acidobacteriia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_2129836_2	861299.J421_1411	6.488e-93	323.0	COG1231@1|root,COG1231@2|Bacteria	2|Bacteria	E	oxidoreductase activity	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_2129836_9	1267535.KB906767_gene3061	2.977e-18	89.0	2DTVW@1|root,33MW2@2|Bacteria,3Y606@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2133413_1	1382359.JIAL01000001_gene1060	1.614e-59	221.0	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria,3Y6QB@57723|Acidobacteria,2JMMD@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_2133413_2	1209072.ALBT01000032_gene2124	1.496e-27	123.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2133413_0	234267.Acid_1210	6.368e-60	217.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amino_oxidase,Ank,Ank_2,Ank_3,Ank_4,Ank_5,PSCyt1,Peptidase_C14,Prenyltrans,SQHop_cyclase_C
HFD2_k127_2144002_5	1267535.KB906767_gene2477	2.479e-57	212.0	2EM83@1|root,33EX7@2|Bacteria,3Y32M@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2144002_4	234267.Acid_6705	4.562e-81	272.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria	57723|Acidobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HFD2_k127_2144002_0	1267535.KB906767_gene2241	4.274e-213	672.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria,2JIEP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_2144002_1	234267.Acid_6503	2.327e-193	609.0	COG1015@1|root,COG1015@2|Bacteria,3Y6GB@57723|Acidobacteria	57723|Acidobacteria	G	Metalloenzyme superfamily	-	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HFD2_k127_2144002_3	1267535.KB906767_gene4086	8.399e-87	304.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF2092,Redoxin
HFD2_k127_2144002_6	234267.Acid_5949	2.735e-57	203.0	COG0817@1|root,COG0817@2|Bacteria,3Y5FH@57723|Acidobacteria	57723|Acidobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD2_k127_2144002_2	234267.Acid_5948	8.04e-122	394.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD2_k127_2144002_10	32049.SYNPCC7002_A1775	5.491e-19	91.0	COG3744@1|root,COG3744@2|Bacteria,1G5SF@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_2144002_11	1112214.AHIS01000003_gene1833	0.0001454	46.0	COG4118@1|root,COG4118@2|Bacteria,1NME9@1224|Proteobacteria,2UMMS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_2155507_0	234267.Acid_7437	1.98e-305	957.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,3Y79C@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HFD2_k127_2155507_10	234267.Acid_7436	1.851e-88	304.0	COG2227@1|root,COG3206@1|root,COG2227@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K03561,ko:K07011,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	1.A.30.2.1,4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_2155507_2	234267.Acid_7435	1.889e-188	597.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD2_k127_2155507_13	234267.Acid_0017	1.904e-71	252.0	COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD2_k127_2155507_7	1267535.KB906767_gene3196	2.323e-112	368.0	COG1192@1|root,COG1192@2|Bacteria,3Y2Y2@57723|Acidobacteria,2JI26@204432|Acidobacteriia	204432|Acidobacteriia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD2_k127_2155507_20	639030.JHVA01000001_gene2516	6.693e-25	111.0	COG0357@1|root,COG0357@2|Bacteria,3Y4W7@57723|Acidobacteria,2JJG7@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD2_k127_2155507_1	1267535.KB906767_gene3195	1.221e-293	911.0	COG0445@1|root,COG0445@2|Bacteria,3Y3E4@57723|Acidobacteria,2JHP3@204432|Acidobacteriia	204432|Acidobacteriia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HFD2_k127_2155507_4	234267.Acid_0014	3.543e-151	488.0	COG0151@1|root,COG0151@2|Bacteria,3Y6E1@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD2_k127_2155507_17	234267.Acid_1042	1.049e-47	171.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
HFD2_k127_2155507_19	234267.Acid_3553	2.314e-27	116.0	2CK2Y@1|root,32SBF@2|Bacteria,3Y5PZ@57723|Acidobacteria	57723|Acidobacteria	S	Photosynthetic reaction centre cytochrome C subunit	-	-	-	-	-	-	-	-	-	-	-	-	CytoC_RC
HFD2_k127_2155507_9	234267.Acid_0761	2.779e-91	309.0	COG1587@1|root,COG1587@2|Bacteria,3Y7CM@57723|Acidobacteria	57723|Acidobacteria	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HFD2_k127_2155507_26	234267.Acid_0764	0.0004181	48.0	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HFD2_k127_2155507_12	234267.Acid_0766	6.039e-80	273.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD2_k127_2155507_21	1267535.KB906767_gene376	4.358e-17	84.0	COG0636@1|root,COG0636@2|Bacteria,3Y5G6@57723|Acidobacteria	57723|Acidobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD2_k127_2155507_6	234267.Acid_1067	1.119e-115	379.0	COG0329@1|root,COG0329@2|Bacteria,3Y30K@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
HFD2_k127_2155507_24	614083.AWQR01000005_gene908	6.089e-06	53.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,2VR41@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	PFAM CheW domain protein	cheW-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HFD2_k127_2155507_18	1267535.KB906767_gene3327	9.965e-38	145.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_2155507_11	234267.Acid_0371	1.504e-85	295.0	2C5RF@1|root,33T7W@2|Bacteria,3Y6IQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2155507_23	234267.Acid_0370	7.428e-15	86.0	2C5RD@1|root,2ZUCI@2|Bacteria,3Y91D@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2155507_14	234267.Acid_0369	2.177e-66	232.0	COG1595@1|root,COG1595@2|Bacteria,3Y7JF@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, luxR family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2155507_3	1267535.KB906767_gene5217	1.32e-180	571.0	COG0183@1|root,COG0183@2|Bacteria,3Y7RP@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_2155507_15	234267.Acid_5662	7.227e-53	190.0	COG1576@1|root,COG1576@2|Bacteria,3Y54B@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD2_k127_2155507_5	234267.Acid_1029	1.089e-117	385.0	COG0276@1|root,COG0276@2|Bacteria,3Y5PB@57723|Acidobacteria	57723|Acidobacteria	H	Ferrochelatase	-	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD2_k127_2155507_8	234267.Acid_0066	1.715e-104	346.0	COG0313@1|root,COG0313@2|Bacteria,3Y32N@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD2_k127_2155507_16	1340493.JNIF01000003_gene2637	1.561e-49	184.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,TonB_C
HFD2_k127_2186990_1	682795.AciX8_3981	1.528e-131	422.0	COG2382@1|root,COG2382@2|Bacteria,3Y5EH@57723|Acidobacteria,2JJUH@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,SGL
HFD2_k127_2186990_0	234267.Acid_1244	4.351e-222	695.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_219359_8	247633.GP2143_18126	0.0001326	51.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_219359_5	247633.GP2143_18121	1.211e-66	237.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_219359_7	551789.ATVJ01000001_gene1039	1.538e-30	124.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_219359_2	1340493.JNIF01000003_gene3859	7.525e-79	273.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_219359_0	234267.Acid_4800	0.0	1190.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
HFD2_k127_219359_3	234267.Acid_4799	1.984e-76	259.0	COG2080@1|root,COG2080@2|Bacteria,3Y4U1@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S -binding domain protein	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_219359_6	1121904.ARBP01000013_gene313	1.8e-41	168.0	COG3391@1|root,COG3391@2|Bacteria,4NH92@976|Bacteroidetes,47JVD@768503|Cytophagia	976|Bacteroidetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_219359_4	36080.S2JBH8	9.036e-73	256.0	28M44@1|root,2QTM1@2759|Eukaryota,39THH@33154|Opisthokonta,3NXIA@4751|Fungi,1GVUJ@112252|Fungi incertae sedis	4751|Fungi	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_219359_1	925409.KI911562_gene2549	2.495e-96	337.0	COG4993@1|root,COG4993@2|Bacteria,4NFK0@976|Bacteroidetes,1IQUR@117747|Sphingobacteriia	976|Bacteroidetes	C	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
HFD2_k127_2198659_6	1267535.KB906767_gene1342	4.613e-16	81.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD2_k127_2198659_2	234267.Acid_5253	5.705e-75	258.0	COG0546@1|root,COG0546@2|Bacteria,3Y4RC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_2198659_5	234267.Acid_5251	1.346e-29	126.0	COG1286@1|root,COG1286@2|Bacteria,3Y8DX@57723|Acidobacteria	57723|Acidobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HFD2_k127_2198659_1	204669.Acid345_2258	1.248e-121	396.0	COG0152@1|root,COG0152@2|Bacteria,3Y2KX@57723|Acidobacteria,2JIG6@204432|Acidobacteriia	204432|Acidobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6,6.3.4.13	ko:K01923,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD2_k127_2198659_0	234267.Acid_7158	2.472e-213	672.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria,3Y6IT@57723|Acidobacteria	57723|Acidobacteria	HM	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_12
HFD2_k127_2198659_3	234267.Acid_5906	7.754e-47	171.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_2200380_2	234267.Acid_1306	6.069e-87	324.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_2200380_1	1267535.KB906767_gene2807	9.999e-116	415.0	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_2200380_0	234267.Acid_7271	6.479e-265	841.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD2_k127_2232620_3	1267535.KB906767_gene4893	1.271e-07	55.0	COG1514@1|root,COG1514@2|Bacteria,3Y5S7@57723|Acidobacteria,2JNFQ@204432|Acidobacteriia	204432|Acidobacteriia	J	2'-5' RNA ligase superfamily	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HFD2_k127_2232620_2	234267.Acid_0314	1.575e-62	220.0	COG0344@1|root,COG0344@2|Bacteria,3Y51D@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HFD2_k127_2232620_0	234267.Acid_0313	4.908e-122	406.0	COG0240@1|root,COG0240@2|Bacteria,3Y3ZH@57723|Acidobacteria	57723|Acidobacteria	C	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HFD2_k127_2232620_1	234267.Acid_0312	1.24e-81	277.0	COG1595@1|root,COG1595@2|Bacteria,3Y2V2@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2232620_4	682795.AciX8_4226	0.0006279	48.0	COG5660@1|root,COG5660@2|Bacteria,3Y556@57723|Acidobacteria,2JJU3@204432|Acidobacteriia	204432|Acidobacteriia	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2266110_0	519989.ECTPHS_02359	3.428e-148	480.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HFD2_k127_2290439_6	1101195.Meth11DRAFT_1464	2.571e-18	94.0	2BUQD@1|root,32Q1F@2|Bacteria,1PJPP@1224|Proteobacteria,2W83R@28216|Betaproteobacteria,2KNSW@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2290439_8	765912.Thimo_2976	2.796e-09	64.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,1SI75@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD2_k127_2290439_2	251221.35211983	1.853e-172	575.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_2290439_5	234267.Acid_4702	3.101e-38	146.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XD@57723|Acidobacteria	57723|Acidobacteria	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_2290439_7	1123023.JIAI01000013_gene3855	5.932e-11	74.0	COG0715@1|root,COG0715@2|Bacteria,2IGX1@201174|Actinobacteria	2|Bacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_2290439_3	234267.Acid_2605	9.744e-104	344.0	COG2133@1|root,COG2133@2|Bacteria,3Y3FI@57723|Acidobacteria	57723|Acidobacteria	G	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD2_k127_2290439_4	204669.Acid345_4026	1.342e-48	187.0	COG0628@1|root,COG0628@2|Bacteria,3Y4A3@57723|Acidobacteria,2JJ4Y@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_2290439_1	266265.Bxe_B2097	2.343e-274	870.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1K29H@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD2_k127_2290439_0	56110.Oscil6304_5340	0.0	1106.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H81U@1150|Oscillatoriales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_2294073_0	1297865.APJD01000003_gene6495	2.763e-187	598.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,3JX83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_2294073_1	1380393.JHVP01000004_gene516	9.79e-91	316.0	28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,4EVDB@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2294073_2	1267534.KB906756_gene712	6.097e-29	118.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2314812_1	1267535.KB906767_gene4776	6.108e-74	253.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria,2JMQ5@204432|Acidobacteriia	204432|Acidobacteriia	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_2314812_0	1267535.KB906767_gene2807	5.789e-132	465.0	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_2314812_3	234267.Acid_1157	0.0003284	46.0	COG3387@1|root,COG3387@2|Bacteria,3Y42X@57723|Acidobacteria	2|Bacteria	G	PFAM Glycoside hydrolase 15-related	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
HFD2_k127_2314812_2	1267535.KB906767_gene4268	1.185e-60	219.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD2_k127_2320956_1	1335760.ASTG01000003_gene1495	3.185e-12	73.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2U8EJ@28211|Alphaproteobacteria,2KCBM@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2320956_0	639030.JHVA01000001_gene1884	2.481e-22	109.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_235504_1	69395.JQLZ01000005_gene3818	4.556e-126	414.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	-	-	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	MFS_1
HFD2_k127_235504_2	234267.Acid_1238	2.265e-36	147.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD2_k127_235504_0	234267.Acid_5315	0.0	1197.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_2362100_0	234267.Acid_5837	2.41e-187	591.0	COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria	57723|Acidobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HFD2_k127_2362100_12	136993.KB900627_gene392	2.4e-36	149.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2362100_2	504832.OCAR_7507	6.304e-160	530.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_2362100_10	1231391.AMZF01000094_gene116	3.925e-50	183.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VRBT@28216|Betaproteobacteria,3T3SV@506|Alcaligenaceae	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HFD2_k127_2362100_4	1040989.AWZU01000008_gene3682	1.238e-98	331.0	COG2863@1|root,COG2863@2|Bacteria,1QXNM@1224|Proteobacteria,2U2HM@28211|Alphaproteobacteria,3JZBZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_2362100_8	247633.GP2143_18126	1.75e-55	206.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2362100_6	378806.STAUR_6894	1.301e-79	284.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_2362100_3	113395.AXAI01000001_gene3005	2.849e-133	436.0	COG2267@1|root,COG2267@2|Bacteria,1MV7P@1224|Proteobacteria,2TSQ8@28211|Alphaproteobacteria,3JTGQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_2362100_7	1500890.JQNL01000001_gene3631	5.498e-70	253.0	COG1228@1|root,COG1228@2|Bacteria,1RCA0@1224|Proteobacteria,1S08B@1236|Gammaproteobacteria,1X5NR@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_2362100_5	1379270.AUXF01000002_gene1145	1.885e-87	304.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_2362100_13	438753.AZC_0879	1.128e-35	154.0	COG0725@1|root,COG0725@2|Bacteria,1RCHM@1224|Proteobacteria,2VGBX@28211|Alphaproteobacteria,3F2CK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K02020,ko:K22003	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD2_k127_2362100_1	936455.KI421499_gene314	3.044e-166	542.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD2_k127_2362100_9	1247726.MIM_c34480	2.051e-52	190.0	COG1073@1|root,COG1073@2|Bacteria,1RFX9@1224|Proteobacteria,2VUIP@28216|Betaproteobacteria,3T5NK@506|Alcaligenaceae	28216|Betaproteobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HFD2_k127_2371183_5	234267.Acid_2868	2.921e-42	163.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD2_k127_2371183_4	794903.OPIT5_26370	2.707e-49	188.0	COG1714@1|root,COG1714@2|Bacteria,46Z5U@74201|Verrucomicrobia,3K8J3@414999|Opitutae	414999|Opitutae	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
HFD2_k127_2371183_1	234267.Acid_3324	6.993e-162	539.0	COG0457@1|root,COG0457@2|Bacteria,3Y7CG@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_2371183_2	1340493.JNIF01000003_gene1498	1.204e-70	244.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_2371183_0	234267.Acid_0409	1.362e-207	656.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD2_k127_2373997_9	504472.Slin_1585	1.476e-13	73.0	COG2227@1|root,COG2227@2|Bacteria,4PNA0@976|Bacteroidetes,47KG3@768503|Cytophagia	976|Bacteroidetes	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_2373997_11	861299.J421_0788	2.511e-07	56.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HFD2_k127_2373997_6	1267535.KB906767_gene1107	2.497e-57	203.0	COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria,2JJ18@204432|Acidobacteriia	204432|Acidobacteriia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD2_k127_2373997_2	234267.Acid_2211	4.575e-157	508.0	COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria	57723|Acidobacteria	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_2373997_7	743299.Acife_0952	1.675e-28	115.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HFD2_k127_2373997_8	317619.ANKN01000208_gene2051	3.834e-25	114.0	COG1598@1|root,COG1598@2|Bacteria,1G97T@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_2373997_4	234267.Acid_0319	4.259e-76	264.0	COG0705@1|root,COG0705@2|Bacteria,3Y4GU@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HFD2_k127_2373997_3	234267.Acid_0320	8.525e-100	331.0	COG0235@1|root,COG0235@2|Bacteria,3Y4E0@57723|Acidobacteria	57723|Acidobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD2_k127_2373997_0	234267.Acid_1030	8.693e-229	720.0	COG0492@1|root,COG0664@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,3Y3SH@57723|Acidobacteria	57723|Acidobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
HFD2_k127_2373997_1	316274.Haur_3348	2.483e-188	603.0	COG0318@1|root,COG0318@2|Bacteria,2G5XA@200795|Chloroflexi,376B4@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2373997_5	1340493.JNIF01000004_gene952	8.07e-67	231.0	COG0671@1|root,COG1075@1|root,COG0671@2|Bacteria,COG1075@2|Bacteria,3Y7BS@57723|Acidobacteria	57723|Acidobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HFD2_k127_2384423_18	234267.Acid_6694	7.733e-24	106.0	2E98K@1|root,333GZ@2|Bacteria,3Y55V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2384423_17	234267.Acid_6695	2.342e-24	106.0	COG0745@1|root,COG0745@2|Bacteria,3Y933@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD2_k127_2384423_10	1267535.KB906767_gene1695	9.053e-101	332.0	COG0745@1|root,COG0745@2|Bacteria,3Y4GX@57723|Acidobacteria,2JJ6P@204432|Acidobacteriia	204432|Acidobacteriia	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2384423_7	1267534.KB906754_gene3501	3.553e-121	396.0	COG0110@1|root,COG0110@2|Bacteria,3Y5CT@57723|Acidobacteria,2JNBI@204432|Acidobacteriia	204432|Acidobacteriia	JM	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HFD2_k127_2384423_4	1123277.KB893185_gene3031	7.535e-126	421.0	COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,47MRG@768503|Cytophagia	976|Bacteroidetes	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_2384423_12	234267.Acid_3830	3.206e-94	320.0	COG0395@1|root,COG0395@2|Bacteria,3Y7HR@57723|Acidobacteria	57723|Acidobacteria	G	Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HFD2_k127_2384423_11	941449.dsx2_3281	1.073e-98	336.0	COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,43CR1@68525|delta/epsilon subdivisions,2X7YK@28221|Deltaproteobacteria,2MHAW@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HFD2_k127_2384423_14	1267533.KB906738_gene2043	6.311e-60	215.0	COG0500@1|root,COG2226@2|Bacteria,3Y7T9@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_2384423_5	234267.Acid_1144	1.638e-122	404.0	COG3391@1|root,COG3391@2|Bacteria,3Y98W@57723|Acidobacteria	57723|Acidobacteria	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_2384423_1	765420.OSCT_1932	6.797e-158	529.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2G7J9@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
HFD2_k127_2384423_2	234267.Acid_5336	3.32e-153	524.0	COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,3Y3IC@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_2384423_20	1151126.AQYI01000002_gene241	2.571e-12	73.0	COG1246@1|root,COG1246@2|Bacteria,2GJBT@201174|Actinobacteria,4FNT2@85023|Microbacteriaceae	201174|Actinobacteria	E	Acetyltransferase (GNAT) domain	argA	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HFD2_k127_2384423_21	1089439.KB902239_gene506	0.0002799	46.0	2DSB0@1|root,33FBC@2|Bacteria,1NGBC@1224|Proteobacteria,1SH3C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2384423_15	1267535.KB906767_gene3462	4.81e-42	160.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria	57723|Acidobacteria	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HFD2_k127_2384423_6	1267535.KB906767_gene3608	3.598e-122	396.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria,2JHPV@204432|Acidobacteriia	204432|Acidobacteriia	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_2384423_0	234267.Acid_6744	1.611e-159	530.0	COG1452@1|root,COG1934@1|root,COG1452@2|Bacteria,COG1934@2|Bacteria,3Y388@57723|Acidobacteria	57723|Acidobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
HFD2_k127_2384423_3	234267.Acid_6201	2.212e-144	472.0	COG0624@1|root,COG0624@2|Bacteria,3Y3J0@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_2384423_13	1267535.KB906767_gene3039	1.873e-63	221.0	COG0764@1|root,COG0764@2|Bacteria,3Y4CG@57723|Acidobacteria,2JJ97@204432|Acidobacteriia	204432|Acidobacteriia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HFD2_k127_2384423_8	234267.Acid_6203	4.369e-113	370.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria	57723|Acidobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HFD2_k127_2384423_9	1267535.KB906767_gene3037	1.322e-108	360.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria,2JIMV@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HFD2_k127_2384423_16	502025.Hoch_4337	1.588e-36	147.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,430ZG@68525|delta/epsilon subdivisions,2WVXP@28221|Deltaproteobacteria,2Z0UY@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241553_3	1267535.KB906767_gene3955	2.767e-70	246.0	COG0628@1|root,COG0628@2|Bacteria,3Y4YN@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_241553_5	234267.Acid_4933	5.57e-65	233.0	COG2370@1|root,COG2370@2|Bacteria	2|Bacteria	O	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ,NicO
HFD2_k127_241553_2	1267535.KB906767_gene2140	6.768e-199	630.0	COG0531@1|root,COG0531@2|Bacteria,3Y3SZ@57723|Acidobacteria,2JI7T@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_241553_6	1340493.JNIF01000003_gene2123	1.032e-36	149.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241553_0	234267.Acid_7637	1.116e-227	733.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_241553_4	234267.Acid_6754	2.787e-68	252.0	29UCR@1|root,30FP6@2|Bacteria,3Y4J8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241553_8	1340493.JNIF01000003_gene2122	7.612e-24	105.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241553_7	1340493.JNIF01000003_gene2123	6.441e-32	135.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241553_1	234267.Acid_5611	1.783e-201	666.0	COG4934@1|root,COG4934@2|Bacteria,3Y37M@57723|Acidobacteria	57723|Acidobacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Peptidase_S8,Pro-kuma_activ
HFD2_k127_2454759_11	65093.PCC7418_1385	1.868e-15	78.0	COG1724@1|root,COG1724@2|Bacteria,1G7S1@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_2454759_1	314271.RB2654_02849	1.714e-129	422.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U256@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_2454759_5	136993.KB900627_gene392	5.314e-73	254.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2454759_9	136993.KB900627_gene393	2.742e-39	158.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2454759_8	1429916.X566_21020	5.285e-47	175.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_2454759_7	234267.Acid_3912	5.329e-56	198.0	COG0545@1|root,COG0545@2|Bacteria,3Y5EV@57723|Acidobacteria	57723|Acidobacteria	O	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HFD2_k127_2454759_3	234267.Acid_3912	1.332e-79	274.0	COG0545@1|root,COG0545@2|Bacteria,3Y5EV@57723|Acidobacteria	57723|Acidobacteria	O	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HFD2_k127_2454759_10	234267.Acid_6849	1.34e-17	86.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,DHC
HFD2_k127_2454759_4	861299.J421_4303	1.687e-73	259.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	gnl	GO:0003674,GO:0003824,GO:0004341,GO:0016787,GO:0016788,GO:0052689	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_2454759_12	1449976.KALB_4132	0.0001304	51.0	COG5517@1|root,COG5517@2|Bacteria,2HPIG@201174|Actinobacteria,4E7RD@85010|Pseudonocardiales	201174|Actinobacteria	Q	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_2454759_6	864702.OsccyDRAFT_3039	4.496e-59	211.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1HBZ4@1150|Oscillatoriales	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_2454759_2	1123366.TH3_13249	3.685e-127	420.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,2JVWB@204441|Rhodospirillales	204441|Rhodospirillales	G	Malonyl-CoA decarboxylase N-terminal domain	-	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HFD2_k127_2454759_0	1232410.KI421425_gene1538	1.361e-173	567.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,43T80@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	PEGA,Plug,TonB_dep_Rec
HFD2_k127_246174_9	941449.dsx2_3042	1.329e-36	144.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2WPQK@28221|Deltaproteobacteria,2M8NI@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HFD2_k127_246174_2	861299.J421_4489	5.062e-132	438.0	COG0161@1|root,COG0161@2|Bacteria,1ZSXF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_246174_0	234267.Acid_7675	0.0	1079.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_246174_6	203124.Tery_3562	2.926e-65	228.0	COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,1HFEV@1150|Oscillatoriales	1117|Cyanobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_246174_4	1242864.D187_002504	1.583e-112	375.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria	1224|Proteobacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_246174_8	1267535.KB906767_gene3620	2.657e-40	151.0	COG1965@1|root,COG1965@2|Bacteria	2|Bacteria	P	Belongs to the frataxin family	cyaY	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008199,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016530,GO:0016722,GO:0016724,GO:0018282,GO:0018283,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0033554,GO:0034599,GO:0034986,GO:0036211,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071840,GO:0098771,GO:0140104,GO:1901564	1.16.3.1	ko:K06202,ko:K19054	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000,ko03029	-	-	iECW_1372.ECW_m4108,iEKO11_1354.EKO11_4552,iWFL_1372.ECW_m4108	Frataxin_Cyay
HFD2_k127_246174_1	1340493.JNIF01000003_gene2709	1.303e-145	471.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD2_k127_246174_3	1267535.KB906767_gene3618	6.843e-128	417.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD2_k127_246174_5	234267.Acid_5410	1.337e-104	347.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
HFD2_k127_246174_7	1267535.KB906767_gene214	1.618e-49	180.0	COG2271@1|root,COG2271@2|Bacteria,3Y638@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_2542447_0	234267.Acid_3814	2.202e-192	625.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria	57723|Acidobacteria	K	chaperone-mediated protein folding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	TPR_8
HFD2_k127_2542447_3	555793.WSK_4046	1.032e-09	64.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2542447_1	1298867.AUES01000054_gene4890	1.37e-110	364.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,2UPRH@28211|Alphaproteobacteria,3K2ZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_2542447_2	8128.ENSONIP00000022387	4.11e-30	137.0	COG0666@1|root,KOG4369@1|root,KOG0504@2759|Eukaryota,KOG4369@2759|Eukaryota,38I05@33154|Opisthokonta,3BHRH@33208|Metazoa,3CU4I@33213|Bilateria,484TK@7711|Chordata,48VFT@7742|Vertebrata,49TED@7898|Actinopterygii	33208|Metazoa	T	Ankyrin repeat and KH	ANKHD1	GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0002376,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007010,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007399,GO:0007423,GO:0008150,GO:0009605,GO:0009607,GO:0009653,GO:0009887,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010506,GO:0010507,GO:0010639,GO:0010821,GO:0010823,GO:0010927,GO:0010941,GO:0016043,GO:0019222,GO:0019730,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030182,GO:0030239,GO:0031032,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031430,GO:0031672,GO:0031674,GO:0032501,GO:0032502,GO:0032989,GO:0033043,GO:0040011,GO:0042692,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043207,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0044085,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0045087,GO:0045214,GO:0046530,GO:0048468,GO:0048513,GO:0048519,GO:0048523,GO:0048592,GO:0048646,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051146,GO:0051704,GO:0051707,GO:0051716,GO:0055001,GO:0055002,GO:0060361,GO:0060548,GO:0061061,GO:0065007,GO:0070925,GO:0071840,GO:0090596,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:1903146,GO:1903147	-	ko:K16726	-	-	-	-	ko00000,ko03036	-	-	-	Ank_2,Ank_4,KH_1
HFD2_k127_254670_1	234267.Acid_1843	6.824e-151	479.0	COG0442@1|root,COG0442@2|Bacteria,3Y67I@57723|Acidobacteria	57723|Acidobacteria	J	Prolyl-tRNA synthetase, C-terminal	-	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HFD2_k127_254670_0	234267.Acid_3538	6.75e-259	805.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD2_k127_2546886_2	1267535.KB906767_gene640	7.273e-123	411.0	COG0004@1|root,COG0004@2|Bacteria,3Y2VR@57723|Acidobacteria,2JHMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD2_k127_2546886_0	234267.Acid_2807	8.298e-215	681.0	COG0405@1|root,COG0405@2|Bacteria,3Y2N0@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_2546886_3	1340493.JNIF01000004_gene334	3.959e-112	368.0	COG1082@1|root,COG1082@2|Bacteria,3Y4EN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_2546886_1	1267535.KB906767_gene5021	4.402e-179	565.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria,2JI7K@204432|Acidobacteriia	204432|Acidobacteriia	J	class II (D K	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_2552755_0	1303518.CCALI_02909	1.5e-38	148.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ytaP	-	-	-	-	-	-	-	-	-	-	-	AXE1,Abhydrolase_7,DLH,Peptidase_S15,Peptidase_S9
HFD2_k127_2552755_1	1172188.KB911820_gene2242	5.564e-21	109.0	COG3227@1|root,COG3227@2|Bacteria,2GN0P@201174|Actinobacteria,4FEV0@85021|Intrasporangiaceae	201174|Actinobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,Peptidase_M36
HFD2_k127_2563494_2	1340493.JNIF01000003_gene4481	5.377e-29	129.0	COG2059@1|root,COG2059@2|Bacteria,3Y572@57723|Acidobacteria	57723|Acidobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_2563494_1	622637.KE124774_gene430	4.969e-29	123.0	COG2059@1|root,COG2059@2|Bacteria,1RGZC@1224|Proteobacteria,2UBKX@28211|Alphaproteobacteria,36ZY4@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_2563494_0	234267.Acid_4255	2.097e-91	307.0	COG1028@1|root,COG1028@2|Bacteria,3Y4CZ@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_2563494_3	886293.Sinac_0726	1.821e-24	116.0	COG0613@1|root,COG0613@2|Bacteria,2J1VB@203682|Planctomycetes	203682|Planctomycetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2563494_4	929556.Solca_1266	8.604e-06	57.0	COG0657@1|root,COG0657@2|Bacteria,4NHDX@976|Bacteroidetes,1IU00@117747|Sphingobacteriia	976|Bacteroidetes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,COesterase
HFD2_k127_2577513_5	234267.Acid_5906	6.322e-89	296.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_2577513_7	234267.Acid_0288	4.927e-30	125.0	COG0394@1|root,COG0394@2|Bacteria,3Y8RC@57723|Acidobacteria	57723|Acidobacteria	T	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
HFD2_k127_2577513_1	234267.Acid_0384	4.054e-205	653.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria	57723|Acidobacteria	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HFD2_k127_2577513_10	886293.Sinac_2505	1.796e-08	60.0	2ESSA@1|root,33KAQ@2|Bacteria,2J1KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2577513_0	1267535.KB906767_gene4522	1.018e-227	744.0	COG1629@1|root,COG4771@2|Bacteria,3Y42A@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_2577513_2	234267.Acid_7377	1.07e-197	639.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2577513_9	1123508.JH636440_gene2753	1.973e-20	91.0	COG1598@1|root,COG1598@2|Bacteria,2J4N9@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2577513_8	1499967.BAYZ01000088_gene5078	6.605e-24	102.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HFD2_k127_2577513_3	330214.NIDE1256	5.589e-107	361.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_2577513_4	234267.Acid_1851	2.356e-90	303.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	phoR_2	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA,PAS_4
HFD2_k127_2598298_11	234267.Acid_7841	1.494e-58	223.0	COG1629@1|root,COG1629@2|Bacteria,3Y78S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_2598298_17	136993.KB900627_gene392	1.774e-32	138.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2598298_13	113395.AXAI01000001_gene3020	6.998e-54	199.0	COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2TTXQ@28211|Alphaproteobacteria,3JTR0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FCD	MA20_45020	-	-	ko:K11475	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_2598298_6	1082931.KKY_114	5.629e-109	362.0	COG0346@1|root,COG0346@2|Bacteria,1P6TT@1224|Proteobacteria,2TQXR@28211|Alphaproteobacteria,3N6NT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15242,ko:K15975	ko00361,ko01100,ko01120,ko01220,map00361,map01100,map01120,map01220	-	R05408	RC02673	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_2598298_9	62928.azo2419	5.539e-89	304.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,2KU96@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_2598298_21	1121479.AUBS01000001_gene3382	0.0004857	43.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2U0DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	BT1
HFD2_k127_2598298_8	861299.J421_4525	2.599e-100	333.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cellulase,Lipase_GDSL_2,PA14,RicinB_lectin_2
HFD2_k127_2598298_0	234267.Acid_2664	1.121e-245	765.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cellulase,Lipase_GDSL_2,PA14,RicinB_lectin_2
HFD2_k127_2598298_5	1217720.ALOX01000034_gene336	6.258e-148	488.0	COG1506@1|root,COG1506@2|Bacteria,1R968@1224|Proteobacteria,2TXT1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_2598298_1	1121124.JNIX01000009_gene2947	8.719e-195	617.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	-	ko:K15064	ko00627,ko01120,map00627,map01120	-	R09270	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_2598298_4	1254432.SCE1572_11415	3.778e-156	501.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_2598298_2	234267.Acid_3097	4.351e-191	615.0	COG4993@1|root,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_2598298_18	136993.KB900627_gene392	1.059e-31	135.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2598298_20	675635.Psed_2591	2.605e-06	59.0	COG0346@1|root,COG0346@2|Bacteria,2HZ9F@201174|Actinobacteria,4E7GG@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HFD2_k127_2598298_10	35720.XP_003648538.1	2.111e-73	256.0	2EBD3@1|root,2SHGJ@2759|Eukaryota,39TQZ@33154|Opisthokonta,3NZP0@4751|Fungi,3QR77@4890|Ascomycota,218S5@147550|Sordariomycetes,3UABU@5139|Sordariales,3HAHA@35718|Chaetomiaceae	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2598298_14	234267.Acid_2033	1.352e-39	166.0	COG0666@1|root,COG0666@2|Bacteria,3Y8C5@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD2_k127_2598298_16	180281.CPCC7001_367	1.314e-33	142.0	COG0491@1|root,COG0491@2|Bacteria,1G400@1117|Cyanobacteria	1117|Cyanobacteria	S	Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_2598298_7	886293.Sinac_1154	2.223e-101	345.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_2598298_3	1340493.JNIF01000004_gene600	1.13e-169	561.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD2_k127_2598298_19	1117314.PCIT_00308	3.584e-26	117.0	2C6NZ@1|root,335K8@2|Bacteria,1N2AP@1224|Proteobacteria,1SFT8@1236|Gammaproteobacteria,2Q4N6@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
HFD2_k127_2598298_12	639030.JHVA01000001_gene1072	1.283e-56	217.0	COG3577@1|root,COG3577@2|Bacteria,3Y7T8@57723|Acidobacteria,2JN2U@204432|Acidobacteriia	204432|Acidobacteriia	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2598298_15	316055.RPE_3525	6.613e-38	152.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3JRZ3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_260316_0	204669.Acid345_3204	1.068e-93	322.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria,2JHS9@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_260316_2	204669.Acid345_3205	9.48e-19	88.0	2EFR0@1|root,339H2@2|Bacteria,3Y5M9@57723|Acidobacteria,2JJPZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_260316_1	204669.Acid345_3206	1.095e-31	126.0	COG3088@1|root,COG3088@2|Bacteria,3Y4YV@57723|Acidobacteria,2JJM2@204432|Acidobacteriia	204432|Acidobacteriia	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HFD2_k127_2628033_1	234267.Acid_1075	1.225e-17	87.0	COG5512@1|root,COG5512@2|Bacteria,3Y95D@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HFD2_k127_2628033_0	234267.Acid_0751	1.227e-145	472.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_2629094_17	1267535.KB906767_gene3485	5.86e-56	199.0	COG1211@1|root,COG1211@2|Bacteria,3Y3VR@57723|Acidobacteria,2JI25@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD2_k127_2629094_12	234267.Acid_1861	2.071e-70	246.0	COG0245@1|root,COG0245@2|Bacteria,3Y3WG@57723|Acidobacteria	57723|Acidobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HFD2_k127_2629094_7	234267.Acid_7430	3.551e-117	394.0	COG0604@1|root,COG0604@2|Bacteria,3Y35U@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_2629094_18	234267.Acid_7429	4.125e-53	192.0	2F82T@1|root,340G8@2|Bacteria,3Y8B9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2629094_14	234267.Acid_7894	4.933e-68	246.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD2_k127_2629094_0	1340493.JNIF01000004_gene294	8.173e-272	846.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_2629094_21	1120950.KB892774_gene1234	2.605e-07	62.0	COG2173@1|root,COG2173@2|Bacteria,2H2GW@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2629094_9	1267535.KB906767_gene3353	1.989e-109	359.0	COG0740@1|root,COG0740@2|Bacteria,3Y2SY@57723|Acidobacteria,2JHPB@204432|Acidobacteriia	204432|Acidobacteriia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_2629094_5	1340493.JNIF01000003_gene1730	2.514e-118	388.0	COG2199@1|root,COG3706@2|Bacteria,3Y7SF@57723|Acidobacteria	57723|Acidobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HFD2_k127_2629094_10	234267.Acid_3470	5.441e-97	332.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_2629094_20	639030.JHVA01000001_gene3636	2.073e-27	116.0	COG0526@1|root,COG0526@2|Bacteria,3Y40P@57723|Acidobacteria,2JMGN@204432|Acidobacteriia	204432|Acidobacteriia	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_2629094_2	204669.Acid345_3039	2.213e-142	468.0	28NTH@1|root,2ZBS4@2|Bacteria,3Y3NN@57723|Acidobacteria,2JIEU@204432|Acidobacteriia	204432|Acidobacteriia	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HFD2_k127_2629094_11	448385.sce4034	1.142e-88	300.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2WMNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02049,ko:K15578,ko:K15579	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	ABC_tran
HFD2_k127_2629094_15	1254432.SCE1572_24295	3.032e-64	230.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2WMNQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02049,ko:K15578,ko:K15579	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	ABC_tran
HFD2_k127_2629094_8	530564.Psta_4090	9.395e-112	365.0	COG0600@1|root,COG0600@2|Bacteria,2IYBH@203682|Planctomycetes	203682|Planctomycetes	P	COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
HFD2_k127_2629094_1	240016.ABIZ01000001_gene4295	1.041e-179	572.0	COG0715@1|root,COG0715@2|Bacteria,46U3D@74201|Verrucomicrobia,2IU5R@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
HFD2_k127_2629094_4	234267.Acid_7731	1.327e-127	412.0	COG2022@1|root,COG2022@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HFD2_k127_2629094_19	1340493.JNIF01000003_gene1288	6.545e-28	122.0	COG3745@1|root,COG3745@2|Bacteria	2|Bacteria	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_2629094_13	1340493.JNIF01000003_gene1287	2.951e-68	243.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_2629094_16	1340493.JNIF01000003_gene1286	9.377e-61	224.0	COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_2629094_6	234267.Acid_6708	8.305e-118	386.0	COG0294@1|root,COG0294@2|Bacteria,3Y4JJ@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD2_k127_2629094_3	234267.Acid_6847	2.804e-142	455.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_2631771_1	234267.Acid_0181	3.095e-69	240.0	COG0007@1|root,COG0007@2|Bacteria	2|Bacteria	H	uroporphyrin-III C-methyltransferase activity	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.79,1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.3,4.99.1.4	ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K04719,ko:K13542	ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947,R05807,R09083	RC00003,RC00435,RC00871,RC01012,RC01034,RC01861,RC02413	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HFD2_k127_2631771_2	543632.JOJL01000020_gene456	2.182e-08	65.0	COG0823@1|root,COG0823@2|Bacteria,2IK6C@201174|Actinobacteria,4DDBC@85008|Micromonosporales	201174|Actinobacteria	U	WD40-like Beta Propeller Repeat	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HFD2_k127_2631771_0	1340493.JNIF01000003_gene3859	9.23e-90	303.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_2649329_3	1267534.KB906759_gene1813	2.77e-112	366.0	COG2141@1|root,COG2141@2|Bacteria,3Y6F5@57723|Acidobacteria,2JHT3@204432|Acidobacteriia	204432|Acidobacteriia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_2649329_4	551789.ATVJ01000001_gene1038	3.463e-60	221.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,2UKQP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2649329_2	1054213.HMPREF9946_00367	8.403e-122	401.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,2JS24@204441|Rhodospirillales	204441|Rhodospirillales	Q	Catechol dioxygenase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C,Dioxygenase_N
HFD2_k127_2649329_0	497321.C664_15668	3.945e-212	666.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	ligB	-	1.13.11.57	ko:K04099	ko00627,ko01120,map00627,map01120	-	R03550,R04280,R09565	RC00233,RC00535,RC02567,RC02694	ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HFD2_k127_2649329_5	204669.Acid345_2503	5.318e-42	169.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	VPA0557	-	-	-	-	-	-	-	-	-	-	-	DUF4292,LolA_like
HFD2_k127_2649329_1	886293.Sinac_1153	1.348e-193	635.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	CBM60,PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_2649329_7	1340493.JNIF01000003_gene2121	6.266e-22	101.0	2CBAE@1|root,32S20@2|Bacteria,3Y93Q@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2649329_6	1192034.CAP_3388	1.216e-34	139.0	COG0346@1|root,COG0346@2|Bacteria,1RAC9@1224|Proteobacteria,432ZG@68525|delta/epsilon subdivisions,2WXG3@28221|Deltaproteobacteria,2Z03C@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_2665556_0	156889.Mmc1_2782	6.589e-102	345.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
HFD2_k127_2665556_1	349966.DJ58_1745	6.171e-19	88.0	COG0582@1|root,COG4644@1|root,COG0582@2|Bacteria,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria,41FXH@629|Yersinia	1236|Gammaproteobacteria	L	Domain of unknown function (DUF4158)	tnpA	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HFD2_k127_2666351_5	1340493.JNIF01000003_gene3623	1.431e-59	211.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria	57723|Acidobacteria	H	MoeZ MoeB domain	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD2_k127_2666351_0	1267535.KB906767_gene3597	1.236e-312	988.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HFD2_k127_2666351_6	1267535.KB906767_gene3598	6.474e-27	121.0	COG0760@1|root,COG0760@2|Bacteria,3Y4KY@57723|Acidobacteria	57723|Acidobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
HFD2_k127_2666351_1	1267535.KB906767_gene3599	4.942e-239	786.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria,2JHS8@204432|Acidobacteriia	204432|Acidobacteriia	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD2_k127_2666351_4	234267.Acid_7345	1.282e-98	327.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_2666351_2	234267.Acid_7344	1.049e-138	454.0	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HFD2_k127_2666351_3	1267535.KB906767_gene3097	6.986e-126	415.0	COG0530@1|root,COG0530@2|Bacteria	2|Bacteria	P	calcium, potassium:sodium antiporter activity	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HFD2_k127_2699678_3	234267.Acid_0012	1.519e-212	670.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD2_k127_2699678_9	1267535.KB906767_gene4672	2.18e-122	398.0	COG0825@1|root,COG0825@2|Bacteria,3Y34D@57723|Acidobacteria,2JHNW@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HFD2_k127_2699678_16	1121877.JQKF01000007_gene981	1.556e-49	185.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_2699678_1	234267.Acid_1539	2.373e-222	700.0	COG0457@1|root,COG0457@2|Bacteria,3Y3PD@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
HFD2_k127_2699678_0	1267535.KB906767_gene2605	0.0	1174.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD2_k127_2699678_17	1279017.AQYJ01000028_gene2525	2.724e-49	187.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_2699678_27	715451.ambt_12010	7.264e-06	57.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_25	234267.Acid_2843	1.876e-11	72.0	COG1366@1|root,COG1366@2|Bacteria	234267.Acid_2843|-	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	-
HFD2_k127_2699678_10	1041930.Mtc_0417	1.948e-107	353.0	COG1533@1|root,arCOG01290@2157|Archaea,2Y1RJ@28890|Euryarchaeota,2NAHF@224756|Methanomicrobia	224756|Methanomicrobia	L	Pfam:Gp37_Gp68	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
HFD2_k127_2699678_20	1173020.Cha6605_0429	6.107e-42	165.0	2BWMX@1|root,2ZIUW@2|Bacteria,1G304@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_5	675635.Psed_3702	1.849e-147	477.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_2699678_8	1121033.AUCF01000003_gene3060	1.784e-136	443.0	COG2404@1|root,COG2404@2|Bacteria,1QW0R@1224|Proteobacteria,2TTRJ@28211|Alphaproteobacteria,2JP8D@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0618 Exopolyphosphatase-related proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_2	234267.Acid_3693	1.081e-213	694.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y78P@57723|Acidobacteria	57723|Acidobacteria	KLTU	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD2_k127_2699678_6	1340493.JNIF01000003_gene2900	6.227e-141	472.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K07004,ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	ASH,CHU_C,DUF11,SGL
HFD2_k127_2699678_19	234267.Acid_7241	5.7e-43	169.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_2699678_14	1267534.KB906754_gene2695	9.466e-54	199.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HFD2_k127_2699678_4	861299.J421_0317	1.867e-173	572.0	28JZZ@1|root,2Z9PZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_24	555793.WSK_4046	1.034e-16	84.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_12	234267.Acid_5940	2.334e-77	283.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_2699678_7	1242864.D187_007794	7.323e-141	466.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,42SI4@68525|delta/epsilon subdivisions,2WPHR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_2699678_15	136993.KB900627_gene392	1.059e-51	192.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_23	136993.KB900627_gene393	2.949e-23	111.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_13	136993.KB900627_gene392	5.172e-59	215.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_22	136993.KB900627_gene391	6.335e-27	117.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria,2UJHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_18	448385.sce1314	1.369e-45	171.0	2DP6I@1|root,330RD@2|Bacteria,1NBSP@1224|Proteobacteria,431S3@68525|delta/epsilon subdivisions,2WW92@28221|Deltaproteobacteria,2YVTV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2699678_21	1232410.KI421413_gene484	1.905e-36	145.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,437CT@68525|delta/epsilon subdivisions,2XA0U@28221|Deltaproteobacteria,43VKC@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_2699678_11	234267.Acid_3160	2.054e-82	276.0	COG0536@1|root,COG0536@2|Bacteria,3Y2J7@57723|Acidobacteria	57723|Acidobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HFD2_k127_2728435_0	1163617.SCD_n00044	4.828e-108	353.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD2_k127_2728435_1	864051.BurJ1DRAFT_3207	4.955e-58	210.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HFD2_k127_2728435_3	292415.Tbd_1157	5.478e-23	103.0	COG2501@1|root,COG2501@2|Bacteria,1PF09@1224|Proteobacteria,2WCCP@28216|Betaproteobacteria,1KTFD@119069|Hydrogenophilales	119069|Hydrogenophilales	S	S4 domain	-	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
HFD2_k127_2728435_5	1120792.JAFV01000001_gene1095	0.0007303	48.0	COG3103@1|root,COG4991@2|Bacteria,1N1DV@1224|Proteobacteria,2UER1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2728435_4	1288494.EBAPG3_9990	1.715e-07	53.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
HFD2_k127_2728435_2	1454004.AW11_00042	4.404e-54	198.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_273091_0	575540.Isop_3679	8.958e-98	336.0	COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A	-	-	3.1.6.4	ko:K01132	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00077,M00079	R07806	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
HFD2_k127_2735746_2	1340493.JNIF01000003_gene4709	2.052e-76	265.0	2EQTB@1|root,33ID2@2|Bacteria	2|Bacteria	S	Lytic polysaccharide mono-oxygenase, cellulose-degrading	-	-	-	-	-	-	-	-	-	-	-	-	LPMO_10
HFD2_k127_2735746_4	1267535.KB906767_gene278	7.876e-31	122.0	COG1278@1|root,COG1278@2|Bacteria,3Y8IF@57723|Acidobacteria	57723|Acidobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_2735746_3	555793.WSK_4047	6.124e-32	140.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2735746_1	234267.Acid_3773	6.222e-82	282.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	3.2.1.20	ko:K01187,ko:K16915	ko00052,ko00500,ko01100,ko02010,map00052,map00500,map01100,map02010	M00246	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko00002,ko01000,ko02000	-	GH31	-	Big_5
HFD2_k127_2735746_0	1267535.KB906767_gene2940	2.305e-180	574.0	COG2133@1|root,COG2133@2|Bacteria,3Y3YZ@57723|Acidobacteria,2JIS0@204432|Acidobacteriia	204432|Acidobacteriia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
HFD2_k127_2735746_5	1267535.KB906767_gene5087	7.211e-06	52.0	COG2010@1|root,COG2010@2|Bacteria,3Y8CD@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2741202_1	234267.Acid_1905	1.043e-144	486.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HFD2_k127_2741202_0	234267.Acid_1906	7.368e-194	645.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	-	-	3.1.11.5,3.6.4.12	ko:K01144,ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF3799,PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_2741202_2	1267535.KB906767_gene3226	2.226e-93	310.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2741202_3	234267.Acid_7295	1.643e-74	253.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HFD2_k127_2745625_2	1267535.KB906767_gene4340	2.461e-114	372.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HFD2_k127_2745625_3	1340493.JNIF01000003_gene2581	1.249e-31	131.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
HFD2_k127_2745625_0	1340493.JNIF01000003_gene2613	7.323e-175	563.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_2745625_1	1340493.JNIF01000003_gene2614	1.193e-129	416.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_2747039_12	861299.J421_4151	1.363e-96	330.0	COG3182@1|root,COG3182@2|Bacteria,1ZUQI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HFD2_k127_2747039_2	234267.Acid_3959	2.298e-182	586.0	COG2982@1|root,COG2982@2|Bacteria,3Y2ZX@57723|Acidobacteria	57723|Acidobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HFD2_k127_2747039_3	296591.Bpro_4325	8.892e-156	520.0	COG3266@1|root,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria,2WHG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_20	525897.Dbac_2186	1.889e-16	81.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_8	639030.JHVA01000001_gene1370	9.33e-107	355.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HH@57723|Acidobacteria,2JNZ8@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_6	1267535.KB906767_gene3727	7.735e-114	375.0	COG2930@1|root,COG2930@2|Bacteria,3Y6Q0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_2747039_5	1267535.KB906767_gene15	6.267e-118	388.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria,2JHQ4@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
HFD2_k127_2747039_11	1267535.KB906767_gene1573	6.719e-99	339.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria,2JICA@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HFD2_k127_2747039_4	234267.Acid_7419	3.663e-141	456.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria	57723|Acidobacteria	S	nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HFD2_k127_2747039_17	234267.Acid_7418	5.532e-31	125.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD2_k127_2747039_7	1340493.JNIF01000003_gene4056	2.7e-108	354.0	COG0689@1|root,COG0689@2|Bacteria,3Y2FP@57723|Acidobacteria	57723|Acidobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HFD2_k127_2747039_16	234267.Acid_7724	2.277e-57	215.0	COG0127@1|root,COG0127@2|Bacteria,3Y7Z7@57723|Acidobacteria	57723|Acidobacteria	F	Ham1 family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD2_k127_2747039_15	1267535.KB906767_gene5194	5.038e-61	222.0	COG0494@1|root,COG0494@2|Bacteria,3Y4N9@57723|Acidobacteria,2JJ9X@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HFD2_k127_2747039_1	234267.Acid_0848	2.648e-271	844.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,3Y2SH@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase X	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HFD2_k127_2747039_14	1267535.KB906767_gene4615	1.571e-86	294.0	COG0053@1|root,COG0053@2|Bacteria,3Y6ZG@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD2_k127_2747039_10	234267.Acid_7297	6.192e-100	338.0	COG0322@1|root,COG0322@2|Bacteria,3Y3HU@57723|Acidobacteria	57723|Acidobacteria	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_9	234267.Acid_7892	5.275e-103	351.0	COG1721@1|root,COG1721@2|Bacteria,3Y5V9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_2747039_0	1267535.KB906767_gene5210	0.0	1405.0	COG1629@1|root,COG4771@2|Bacteria,3Y3Y0@57723|Acidobacteria,2JIYU@204432|Acidobacteriia	1267535.KB906767_gene5210|-	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_13	1267535.KB906767_gene954	2.051e-88	300.0	2BKZZ@1|root,32FGS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HFD2_k127_2747039_19	481448.Minf_2067	2.551e-18	89.0	COG0438@1|root,COG3551@1|root,COG0438@2|Bacteria,COG3551@2|Bacteria,46X4B@74201|Verrucomicrobia,37H9R@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD2_k127_2747039_23	1419583.V466_30350	1.982e-14	79.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,1RVTE@1236|Gammaproteobacteria,1YUCY@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2747039_22	551789.ATVJ01000001_gene1041	3.727e-15	79.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,2UDGH@28211|Alphaproteobacteria,440IK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2764389_15	1340493.JNIF01000003_gene1706	7.942e-09	59.0	COG3166@1|root,COG3166@2|Bacteria,3Y4GJ@57723|Acidobacteria	57723|Acidobacteria	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HFD2_k127_2764389_6	234267.Acid_0046	1.285e-75	263.0	COG4972@1|root,COG4972@2|Bacteria,3Y4X3@57723|Acidobacteria	57723|Acidobacteria	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD2_k127_2764389_0	234267.Acid_0045	6.419e-291	899.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria	57723|Acidobacteria	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_2764389_3	1267535.KB906767_gene3543	8.253e-165	527.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD2_k127_2764389_7	234267.Acid_7250	7.796e-69	237.0	COG0386@1|root,COG0386@2|Bacteria,3Y4B8@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HFD2_k127_2764389_14	1267535.KB906767_gene2771	1.68e-10	67.0	28J3W@1|root,33Y8C@2|Bacteria,3Y7WA@57723|Acidobacteria	57723|Acidobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD2_k127_2764389_8	1121920.AUAU01000015_gene1129	2.545e-58	212.0	COG3647@1|root,COG3647@2|Bacteria,3Y8PM@57723|Acidobacteria	57723|Acidobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2238
HFD2_k127_2764389_1	234267.Acid_4983	1.329e-217	687.0	COG1620@1|root,COG1620@2|Bacteria,3Y2ZA@57723|Acidobacteria	57723|Acidobacteria	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HFD2_k127_2764389_10	234267.Acid_3876	2.992e-44	164.0	COG5507@1|root,COG5507@2|Bacteria,3Y82V@57723|Acidobacteria	57723|Acidobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD2_k127_2764389_13	234267.Acid_2922	9.05e-21	99.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria	57723|Acidobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HFD2_k127_2764389_5	1267535.KB906767_gene2891	7.897e-134	439.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K03407,ko:K07678	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00475,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HFD2_k127_2764389_12	1267535.KB906767_gene2892	1.255e-36	141.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD2_k127_2764389_2	1267535.KB906767_gene2893	1.271e-188	599.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_2764389_9	1267535.KB906767_gene2875	1.032e-52	207.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_2764389_4	234267.Acid_2454	1.637e-163	536.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_2454|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD2_k127_2764389_11	234267.Acid_2701	7.555e-44	171.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_2764986_9	1123239.KB898629_gene2609	7.853e-21	98.0	COG1082@1|root,COG1082@2|Bacteria,1TS20@1239|Firmicutes,4HD4V@91061|Bacilli	91061|Bacilli	G	COG1082 Sugar phosphate isomerases epimerases	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_2764986_5	1123242.JH636434_gene5127	7.706e-78	273.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,NHL
HFD2_k127_2764986_10	555793.WSK_3235	2.767e-19	99.0	2EVK9@1|root,33P0C@2|Bacteria,1P9RH@1224|Proteobacteria,2UVJR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2764986_1	1267535.KB906767_gene942	2.778e-151	518.0	COG1629@1|root,COG4771@2|Bacteria,3Y2ZK@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_2764986_6	627192.SLG_25160	2.117e-56	209.0	2EVK9@1|root,33P0C@2|Bacteria,1P9RH@1224|Proteobacteria,2UVJR@28211|Alphaproteobacteria,2KE01@204457|Sphingomonadales	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2764986_4	1298867.AUES01000001_gene1607	2.13e-89	304.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,3JQU4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_2764986_2	234267.Acid_1641	1.207e-135	441.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_2764986_0	1267535.KB906767_gene2727	9.187e-305	939.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia	204432|Acidobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD2_k127_2764986_8	234267.Acid_6746	1.223e-43	160.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria	57723|Acidobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD2_k127_2764986_7	234267.Acid_2157	3.214e-52	188.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD2_k127_2764986_3	234267.Acid_2158	7.678e-131	432.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_27890_3	861299.J421_0887	1.498e-120	399.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_27890_13	234267.Acid_0024	5.293e-11	74.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_27890_5	234267.Acid_0181	3.632e-86	293.0	COG0007@1|root,COG0007@2|Bacteria	2|Bacteria	H	uroporphyrin-III C-methyltransferase activity	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.79,1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.3,4.99.1.4	ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K04719,ko:K13542	ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947,R05807,R09083	RC00003,RC00435,RC00871,RC01012,RC01034,RC01861,RC02413	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HFD2_k127_27890_9	234267.Acid_5089	2.529e-61	214.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HFD2_k127_27890_1	1267535.KB906767_gene2678	8.577e-183	576.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria,2JHZ6@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HFD2_k127_27890_4	234267.Acid_5091	1.293e-100	331.0	COG0522@1|root,COG0522@2|Bacteria,3Y2I1@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HFD2_k127_27890_7	1267535.KB906767_gene2680	5.667e-66	227.0	COG0100@1|root,COG0100@2|Bacteria,3Y4BS@57723|Acidobacteria,2JJ4Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HFD2_k127_27890_8	234267.Acid_5093	2.396e-62	216.0	COG0099@1|root,COG0099@2|Bacteria,3Y4KC@57723|Acidobacteria	57723|Acidobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HFD2_k127_27890_11	234267.Acid_5094	4.069e-14	74.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HFD2_k127_27890_12	1382359.JIAL01000001_gene1718	4.643e-12	70.0	COG0361@1|root,COG0361@2|Bacteria,3Y55Z@57723|Acidobacteria,2JJUQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD2_k127_27890_2	234267.Acid_5096	6.073e-123	401.0	COG0024@1|root,COG0024@2|Bacteria,3Y2HJ@57723|Acidobacteria	57723|Acidobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD2_k127_27890_6	1267535.KB906767_gene2684	1.663e-68	241.0	COG0563@1|root,COG0563@2|Bacteria,3Y421@57723|Acidobacteria,2JI14@204432|Acidobacteriia	57723|Acidobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD2_k127_27890_0	1340493.JNIF01000003_gene3227	3.991e-232	725.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD2_k127_27890_10	1267535.KB906767_gene2686	1.807e-40	156.0	COG0200@1|root,COG0200@2|Bacteria,3Y4JC@57723|Acidobacteria,2JJ94@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD2_k127_2793298_1	1408473.JHXO01000007_gene902	4.034e-185	592.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,2FNAR@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b
HFD2_k127_2793298_3	1123073.KB899241_gene2886	1.621e-89	305.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
HFD2_k127_2793298_4	1297865.APJD01000007_gene2062	7.509e-67	238.0	COG3386@1|root,COG3386@2|Bacteria,1MXB7@1224|Proteobacteria,2U2RZ@28211|Alphaproteobacteria,3JVA8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HFD2_k127_2793298_5	1267535.KB906767_gene4017	5.393e-46	173.0	COG1393@1|root,COG1393@2|Bacteria,3Y7VT@57723|Acidobacteria	57723|Acidobacteria	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
HFD2_k127_2793298_6	234267.Acid_2955	1.755e-26	117.0	2FBCE@1|root,343I9@2|Bacteria,3Y8Q4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2793298_8	1121447.JONL01000001_gene735	4.207e-06	49.0	2EG8N@1|root,33A0G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2793298_0	682795.AciX8_3594	3.93e-227	731.0	COG1629@1|root,COG4771@2|Bacteria,3Y461@57723|Acidobacteria,2JHPM@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_2793298_2	234267.Acid_5120	4.168e-117	378.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_2797512_2	63737.Npun_F5462	2.691e-125	413.0	COG1409@1|root,COG1409@2|Bacteria,1G4KM@1117|Cyanobacteria,1HNI0@1161|Nostocales	1117|Cyanobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_2797512_4	1396141.BATP01000019_gene1578	1.317e-43	171.0	2BJZS@1|root,32ECM@2|Bacteria,46X9R@74201|Verrucomicrobia,2IV50@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD2_k127_2797512_5	234267.Acid_3643	1.401e-22	108.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	LpoB,Sel1
HFD2_k127_2797512_7	1122921.KB898185_gene3796	0.000297	54.0	COG3280@1|root,COG4733@1|root,COG5492@1|root,COG3280@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1V98K@1239|Firmicutes,4HW4Q@91061|Bacilli,26TRU@186822|Paenibacillaceae	91061|Bacilli	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2797512_3	237368.SCABRO_02367	4.476e-61	235.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.1.3.1,3.1.3.5,3.6.1.45	ko:K01077,ko:K11751	ko00230,ko00240,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00730,map00760,map00790,map01100,map01110,map02020	M00126	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02135,R02323,R02719,R03346,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Big_2,Cadherin-like,Cu_amine_oxidN1,DUF4430,FIVAR,Flg_new,Prenyltrans,SLH
HFD2_k127_2797512_6	641491.DND132_0533	4.349e-13	79.0	2EMZ0@1|root,33FM5@2|Bacteria,1PAI1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2797512_0	1340493.JNIF01000003_gene3478	3.657e-175	586.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_2797512_1	234267.Acid_1210	2.286e-141	473.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amino_oxidase,Ank,Ank_2,Ank_3,Ank_4,Ank_5,PSCyt1,Peptidase_C14,Prenyltrans,SQHop_cyclase_C
HFD2_k127_2797512_8	156889.Mmc1_1104	0.0004335	47.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG3000 Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_2803781_5	1267535.KB906767_gene3553	1.116e-110	362.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria,2JHR1@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HFD2_k127_2803781_7	234267.Acid_3379	3.37e-100	337.0	COG0547@1|root,COG0547@2|Bacteria,3Y3YF@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_2803781_15	1267533.KB906740_gene137	1.446e-23	110.0	29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2803781_0	234267.Acid_5743	3.512e-311	974.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6PH@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
HFD2_k127_2803781_2	234267.Acid_5744	7.196e-173	562.0	COG2304@1|root,COG2304@2|Bacteria,3Y6TM@57723|Acidobacteria	57723|Acidobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HFD2_k127_2803781_4	1267535.KB906767_gene3460	2.448e-121	396.0	COG1721@1|root,COG1721@2|Bacteria,3Y6DV@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_2803781_6	1294142.CINTURNW_3013	4.268e-103	346.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,36DXF@31979|Clostridiaceae	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_2803781_9	270374.MELB17_00270	4.294e-69	247.0	COG0535@1|root,COG0535@2|Bacteria,1RBC4@1224|Proteobacteria,1SKEW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_2803781_11	1229172.JQFA01000002_gene4989	1.607e-62	227.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HFD2_k127_2803781_12	861299.J421_0862	1.438e-45	179.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_2803781_10	1382306.JNIM01000001_gene1927	3.05e-65	241.0	COG2124@1|root,COG2124@2|Bacteria,2G623@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HFD2_k127_2803781_13	485913.Krac_8193	4.032e-45	176.0	COG1957@1|root,COG1957@2|Bacteria,2G6R6@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HFD2_k127_2803781_14	204669.Acid345_0797	6.039e-28	121.0	COG3650@1|root,COG3650@2|Bacteria	2|Bacteria	CO	response to hydrogen peroxide	-	-	-	ko:K08985	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_2803781_3	1267535.KB906767_gene1182	4.29e-133	429.0	COG3186@1|root,COG3186@2|Bacteria,3Y3K5@57723|Acidobacteria,2JHN0@204432|Acidobacteriia	204432|Acidobacteriia	E	Biopterin-dependent aromatic amino acid hydroxylase	-	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HFD2_k127_2803781_1	234267.Acid_7288	7.42e-184	586.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,3Y4NX@57723|Acidobacteria	57723|Acidobacteria	GM	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD2_k127_2803781_8	234267.Acid_7287	1.809e-86	292.0	COG0461@1|root,COG0461@2|Bacteria,3Y6JQ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosyl transferase domain	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD2_k127_2803781_16	886293.Sinac_3870	3.064e-05	52.0	COG3119@1|root,COG3119@2|Bacteria,2IXH3@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD2_k127_2843044_16	1267535.KB906767_gene2656	6.838e-37	140.0	COG1898@1|root,COG1898@2|Bacteria,3Y5V0@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD2_k127_2843044_3	234267.Acid_6228	5.321e-159	506.0	COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_2843044_8	234267.Acid_2629	1.638e-88	314.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_2843044_14	111780.Sta7437_4160	1.953e-51	200.0	COG0728@1|root,COG0728@2|Bacteria,1G1YC@1117|Cyanobacteria,3VHRP@52604|Pleurocapsales	1117|Cyanobacteria	S	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_2843044_6	1123368.AUIS01000044_gene15	1.784e-102	353.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,2ND0X@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD2_k127_2843044_9	234267.Acid_0379	9.042e-68	238.0	COG3568@1|root,COG3568@2|Bacteria,3Y4HM@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_2843044_7	1340493.JNIF01000004_gene437	2.974e-92	309.0	COG0101@1|root,COG0101@2|Bacteria,3Y833@57723|Acidobacteria	57723|Acidobacteria	J	tRNA pseudouridine synthase	-	-	-	-	-	-	-	-	-	-	-	-	PseudoU_synth_1
HFD2_k127_2843044_5	1267535.KB906767_gene4416	1.286e-123	400.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria,2JI06@204432|Acidobacteriia	57723|Acidobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_11,Hexapep
HFD2_k127_2843044_18	864069.MicloDRAFT_00046690	4.825e-26	115.0	COG1845@1|root,COG1845@2|Bacteria,1MXAB@1224|Proteobacteria,2TRFQ@28211|Alphaproteobacteria,1JUYF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	coxO	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_2843044_10	234267.Acid_0540	3.168e-67	237.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HFD2_k127_2843044_12	1340493.JNIF01000003_gene1311	1.055e-64	231.0	COG1295@1|root,COG1295@2|Bacteria,3Y3AJ@57723|Acidobacteria	57723|Acidobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD2_k127_2843044_20	639030.JHVA01000001_gene1656	1.352e-18	92.0	COG1555@1|root,COG1555@2|Bacteria,3Y8EF@57723|Acidobacteria,2JNFN@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HFD2_k127_2843044_2	103733.JNYO01000025_gene8924	1.697e-167	537.0	COG1032@1|root,COG1032@2|Bacteria,2ISAI@201174|Actinobacteria	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_2843044_4	234267.Acid_0476	2.097e-129	424.0	COG1181@1|root,COG1181@2|Bacteria,3Y7GI@57723|Acidobacteria	57723|Acidobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HFD2_k127_2843044_0	1267535.KB906767_gene970	6.519e-200	631.0	COG1004@1|root,COG1004@2|Bacteria,3Y3GR@57723|Acidobacteria,2JHU0@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_2843044_13	1267535.KB906767_gene2653	2.356e-58	212.0	COG2912@1|root,COG2912@2|Bacteria,3Y53Z@57723|Acidobacteria,2JMYF@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HFD2_k127_2843044_15	1267535.KB906767_gene71	1.19e-45	167.0	COG2924@1|root,COG2924@2|Bacteria,3Y4ZS@57723|Acidobacteria	57723|Acidobacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HFD2_k127_2843044_17	234267.Acid_0591	3.412e-31	131.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_2843044_1	1267535.KB906767_gene4447	1.754e-182	580.0	COG1432@1|root,COG1432@2|Bacteria,3Y64C@57723|Acidobacteria	57723|Acidobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HFD2_k127_2843044_11	1267535.KB906767_gene4446	5.838e-67	229.0	COG2185@1|root,COG2185@2|Bacteria,3Y4YE@57723|Acidobacteria,2JMRD@204432|Acidobacteriia	204432|Acidobacteriia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HFD2_k127_2845877_23	234267.Acid_2766	0.0009869	44.0	COG0613@1|root,COG0613@2|Bacteria,3Y451@57723|Acidobacteria	57723|Acidobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2845877_6	883.DvMF_0881	1.226e-94	318.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2M7VZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_2845877_7	234267.Acid_3568	7.345e-89	301.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HFD2_k127_2845877_11	234267.Acid_2866	1.582e-58	211.0	2DBU8@1|root,2ZB4S@2|Bacteria,3Y31B@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HFD2_k127_2845877_8	1340493.JNIF01000004_gene1042	1.24e-77	272.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2845877_15	1340493.JNIF01000003_gene2984	2.606e-21	98.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HFD2_k127_2845877_17	234267.Acid_2133	2.721e-19	96.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	puhB	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
HFD2_k127_2845877_1	1267535.KB906767_gene838	3.975e-191	608.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_2845877_5	1340493.JNIF01000003_gene1919	7.753e-108	368.0	COG5000@1|root,COG5000@2|Bacteria,3Y32Z@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_2845877_12	1340493.JNIF01000003_gene1921	3.418e-35	144.0	COG2885@1|root,COG2885@2|Bacteria,3Y425@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_2845877_2	1382303.JPOM01000001_gene1745	1.268e-150	502.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2KF9M@204458|Caulobacterales	204458|Caulobacterales	CG	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ
HFD2_k127_2845877_16	631362.Thi970DRAFT_03064	2.916e-20	96.0	28JU1@1|root,2Z9J4@2|Bacteria,1R7R9@1224|Proteobacteria,1RS2X@1236|Gammaproteobacteria,1X0WU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2845877_3	234267.Acid_0301	4.691e-129	419.0	COG0123@1|root,COG0123@2|Bacteria,3Y5CR@57723|Acidobacteria	57723|Acidobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_2845877_14	234267.Acid_5771	1.299e-27	117.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_2845877_4	1382359.JIAL01000001_gene350	8.534e-129	422.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50,Peptidase_M50B
HFD2_k127_2845877_19	1207058.L53_11130	2.389e-15	79.0	2EGHT@1|root,33A9W@2|Bacteria,1NHZD@1224|Proteobacteria,2V70B@28211|Alphaproteobacteria,43YSN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2845877_9	443144.GM21_0128	2.181e-75	257.0	COG3861@1|root,COG3861@2|Bacteria,1QE0P@1224|Proteobacteria,42TDZ@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD2_k127_2845877_21	926561.KB900617_gene1719	3.693e-08	64.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WB7F@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
HFD2_k127_2845877_22	1168059.KB899087_gene3133	1.321e-05	49.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_2845877_18	240015.ACP_2885	1.822e-15	79.0	2ENFH@1|root,33G2W@2|Bacteria,3Y8R1@57723|Acidobacteria,2JNJI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2845877_13	760568.Desku_0092	2.314e-29	121.0	COG1487@1|root,COG1487@2|Bacteria,1VKMK@1239|Firmicutes,24V7P@186801|Clostridia	186801|Clostridia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HFD2_k127_2845877_10	234267.Acid_7855	2.543e-66	231.0	COG2323@1|root,COG2323@2|Bacteria,3Y4R1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HFD2_k127_2845877_0	234267.Acid_7844	1.593e-220	699.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,3Y2VV@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase LigD, ligase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_291406_2	627192.SLG_31390	1.185e-46	187.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
HFD2_k127_291406_1	1340493.JNIF01000003_gene1475	2.69e-97	332.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_291406_0	234267.Acid_5827	5.465e-178	586.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_291406_3	1279017.AQYJ01000028_gene2525	2.028e-37	153.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_291406_4	1267534.KB906758_gene2527	1.463e-25	117.0	COG2027@1|root,COG2027@2|Bacteria,3Y7ZS@57723|Acidobacteria,2JMZE@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD2_k127_291406_6	682795.AciX8_2406	1.301e-06	51.0	COG2027@1|root,COG2027@2|Bacteria	2|Bacteria	M	serine-type D-Ala-D-Ala carboxypeptidase activity	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	DUF3738,Peptidase_S13
HFD2_k127_291406_5	251229.Chro_4769	1.181e-21	99.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,3VJSQ@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_2916512_16	1267535.KB906767_gene3509	3.323e-39	160.0	COG2956@1|root,COG2956@2|Bacteria	2|Bacteria	G	lipopolysaccharide metabolic process	-	-	-	ko:K08309,ko:K19804	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD2_k127_2916512_2	1340493.JNIF01000004_gene911	2.923e-148	483.0	COG3104@1|root,COG3104@2|Bacteria,3Y6W5@57723|Acidobacteria	57723|Acidobacteria	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD2_k127_2916512_0	1267535.KB906767_gene2442	1.162e-204	646.0	COG0821@1|root,COG0821@2|Bacteria,3Y2GU@57723|Acidobacteria,2JHND@204432|Acidobacteriia	204432|Acidobacteriia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HFD2_k127_2916512_11	1333998.M2A_2027	1.121e-86	295.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,4BT6G@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_2916512_18	1340493.JNIF01000004_gene374	7.239e-30	124.0	297M3@1|root,2ZUU3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2916512_19	1382359.JIAL01000001_gene1053	1.105e-22	99.0	2C987@1|root,331JK@2|Bacteria,3Y5R0@57723|Acidobacteria,2JK28@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2916512_4	234267.Acid_2598	3.221e-141	458.0	COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria	57723|Acidobacteria	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HFD2_k127_2916512_7	234267.Acid_5230	4.623e-118	387.0	COG0489@1|root,COG0489@2|Bacteria,3Y38H@57723|Acidobacteria	57723|Acidobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HFD2_k127_2916512_1	234267.Acid_6976	1.069e-165	540.0	28JZQ@1|root,2Z9PN@2|Bacteria,3Y4UW@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2916512_20	1469607.KK073768_gene3494	2.123e-16	91.0	COG4188@1|root,COG4188@2|Bacteria,1G2BZ@1117|Cyanobacteria,1HIDF@1161|Nostocales	1117|Cyanobacteria	S	PFAM Alpha beta hydrolase of	-	-	-	-	-	-	-	-	-	-	-	-	DUF1400,Hydrolase_4,PAF-AH_p_II
HFD2_k127_2916512_6	204669.Acid345_4010	1.183e-131	429.0	COG4638@1|root,COG4638@2|Bacteria,3Y547@57723|Acidobacteria,2JNCI@204432|Acidobacteriia	204432|Acidobacteriia	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_2916512_8	1340493.JNIF01000004_gene746	1.161e-114	379.0	COG0533@1|root,COG0533@2|Bacteria,3Y2PN@57723|Acidobacteria	57723|Acidobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_2916512_9	28072.Nos7524_0629	5.232e-104	353.0	COG4637@1|root,COG4637@2|Bacteria,1G1A2@1117|Cyanobacteria,1HKA6@1161|Nostocales	1117|Cyanobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
HFD2_k127_2916512_13	1121405.dsmv_3725	6.991e-70	242.0	2BVDG@1|root,32QTE@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
HFD2_k127_2916512_5	234267.Acid_6354	3.887e-139	449.0	COG0809@1|root,COG0809@2|Bacteria,3Y336@57723|Acidobacteria	57723|Acidobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_2916512_15	234267.Acid_1753	4.552e-56	217.0	2BZ8T@1|root,33VM1@2|Bacteria,3Y7Y3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2916512_12	234267.Acid_2371	1.567e-74	259.0	COG2215@1|root,COG2215@2|Bacteria,3Y73Y@57723|Acidobacteria	2|Bacteria	P	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	DsbD_2,NicO
HFD2_k127_2916512_17	234267.Acid_2219	2.024e-35	140.0	COG0784@1|root,COG0784@2|Bacteria,3Y4W5@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_2916512_3	1340493.JNIF01000004_gene505	8.261e-145	468.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD2_k127_2916512_14	1267535.KB906767_gene2172	1.383e-65	237.0	COG0705@1|root,COG0705@2|Bacteria,3Y45U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_2916512_10	627192.SLG_31280	1.291e-93	314.0	COG4341@1|root,COG4341@2|Bacteria,1RAX5@1224|Proteobacteria,2U5RV@28211|Alphaproteobacteria,2KAD4@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2916512_22	639030.JHVA01000001_gene3979	3.608e-06	58.0	COG2010@1|root,COG2010@2|Bacteria,3Y9G7@57723|Acidobacteria,2JNPI@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_2917258_1	234267.Acid_7828	1.896e-125	409.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_2917258_2	204669.Acid345_0125	3.473e-80	273.0	COG2085@1|root,COG2085@2|Bacteria,3Y5CN@57723|Acidobacteria,2JNMR@204432|Acidobacteriia	204432|Acidobacteriia	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD2_k127_2917258_3	234267.Acid_5322	1.434e-73	258.0	COG3802@1|root,COG3802@2|Bacteria,3Y6GZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2917258_5	1198114.AciX9_3536	8.374e-64	227.0	COG1309@1|root,COG1309@2|Bacteria,3Y4QT@57723|Acidobacteria,2JN0G@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_2917258_4	1192034.CAP_5903	5.946e-72	253.0	2DNQQ@1|root,32YKT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_2917258_0	1382359.JIAL01000001_gene522	2.15e-238	742.0	COG1249@1|root,COG1249@2|Bacteria,3Y3ZK@57723|Acidobacteria,2JIMX@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_2937039_0	234267.Acid_6406	7.592e-105	349.0	COG4974@1|root,COG4974@2|Bacteria,3Y3D0@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_2937039_2	234267.Acid_6405	1.56e-41	159.0	2C62N@1|root,32TCB@2|Bacteria,3Y55K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2937039_3	234267.Acid_5817	2.375e-28	121.0	COG1514@1|root,COG1514@2|Bacteria,3Y5Y2@57723|Acidobacteria	57723|Acidobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HFD2_k127_2937039_4	234267.Acid_1396	1.051e-19	94.0	2FE1U@1|root,34620@2|Bacteria,3Y8MC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2937039_1	234267.Acid_1395	1.304e-46	177.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Fer4_15,Patatin
HFD2_k127_2937039_5	520709.F985_01155	4.57e-07	55.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,3NJBY@468|Moraxellaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_2970135_1	234267.Acid_2354	2.094e-71	249.0	COG1561@1|root,COG1561@2|Bacteria,3Y2HQ@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HFD2_k127_2970135_0	1267535.KB906767_gene1434	3.006e-238	756.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria,2JI79@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_2970135_2	1267535.KB906767_gene1433	2.139e-32	128.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_2976898_3	234267.Acid_2410	5.544e-145	462.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HFD2_k127_2976898_23	234267.Acid_4894	1.846e-45	170.0	COG2365@1|root,COG2365@2|Bacteria,3Y8BW@57723|Acidobacteria	57723|Acidobacteria	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase2
HFD2_k127_2976898_17	204669.Acid345_4483	1.531e-71	268.0	COG4206@1|root,COG4206@2|Bacteria,3Y42S@57723|Acidobacteria,2JHUU@204432|Acidobacteriia	204432|Acidobacteriia	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_2976898_18	1340493.JNIF01000003_gene4442	1.003e-64	232.0	COG0614@1|root,COG0614@2|Bacteria,3Y7Z8@57723|Acidobacteria	57723|Acidobacteria	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HFD2_k127_2976898_22	446468.Ndas_2653	2.675e-50	190.0	COG1120@1|root,COG1120@2|Bacteria,2GN5T@201174|Actinobacteria	201174|Actinobacteria	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_2976898_13	278963.ATWD01000001_gene1755	4.616e-83	287.0	COG0609@1|root,COG0609@2|Bacteria,3Y7KJ@57723|Acidobacteria	57723|Acidobacteria	P	FecCD transport family	-	-	-	-	-	-	-	-	-	-	-	-	FecCD
HFD2_k127_2976898_25	1122223.KB890697_gene1013	5.579e-40	156.0	COG2087@1|root,COG2087@2|Bacteria	2|Bacteria	H	cobinamide kinase activity	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62,6.3.5.10	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R05225,R06558	RC00002,RC00010,RC00428,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	CobU
HFD2_k127_2976898_27	1340493.JNIF01000003_gene1454	8.481e-32	138.0	COG0368@1|root,COG0368@2|Bacteria,3Y6M4@57723|Acidobacteria	57723|Acidobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HFD2_k127_2976898_10	868595.Desca_0577	2.318e-94	323.0	COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,260Q0@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HFD2_k127_2976898_8	1267535.KB906767_gene1305	4.801e-99	338.0	COG1538@1|root,COG1538@2|Bacteria,3Y4MP@57723|Acidobacteria	57723|Acidobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_2976898_12	1267535.KB906767_gene3994	1.978e-83	282.0	COG0755@1|root,COG0755@2|Bacteria,3Y4FE@57723|Acidobacteria,2JJ1X@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HFD2_k127_2976898_15	234267.Acid_4237	3.903e-77	263.0	COG2386@1|root,COG2386@2|Bacteria,3Y3G1@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c-type biogenesis protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HFD2_k127_2976898_9	234267.Acid_4236	1.722e-95	317.0	COG1131@1|root,COG1131@2|Bacteria,3Y4M9@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HFD2_k127_2976898_19	1267535.KB906767_gene3997	2.121e-61	226.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_24	1267535.KB906767_gene3998	1.154e-40	153.0	2EFR0@1|root,339H2@2|Bacteria,3Y5M9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_33	234267.Acid_4233	1.655e-18	91.0	COG3088@1|root,COG3088@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564	-	ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmH
HFD2_k127_2976898_2	1340493.JNIF01000003_gene4699	5.963e-295	919.0	COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD2_k127_2976898_26	1267535.KB906767_gene4001	2.024e-35	140.0	COG2332@1|root,COG2332@2|Bacteria,3Y57C@57723|Acidobacteria,2JJR8@204432|Acidobacteriia	204432|Acidobacteriia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HFD2_k127_2976898_20	234267.Acid_4096	2.537e-61	218.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2976898_39	316067.Geob_2170	0.0001698	50.0	COG0484@1|root,COG0484@2|Bacteria,1QXP1@1224|Proteobacteria,43C4V@68525|delta/epsilon subdivisions,2X7F8@28221|Deltaproteobacteria,43W46@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD2_k127_2976898_38	1232683.ADIMK_0036	1.62e-06	55.0	2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_0	1340493.JNIF01000003_gene4840	0.0	1248.0	COG2609@1|root,COG2609@2|Bacteria,3Y2M3@57723|Acidobacteria	57723|Acidobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_2976898_34	502025.Hoch_0794	1.333e-16	83.0	2DRHR@1|root,33BTC@2|Bacteria,1NJ21@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_35	211165.AJLN01000116_gene3258	3.256e-14	77.0	COG4634@1|root,COG4634@2|Bacteria,1GJHF@1117|Cyanobacteria,1JJ0G@1189|Stigonemataceae	1117|Cyanobacteria	S	Mut7-C RNAse domain	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
HFD2_k127_2976898_36	518766.Rmar_0293	9.157e-12	67.0	COG2442@1|root,COG2442@2|Bacteria,4NX9P@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD2_k127_2976898_4	234267.Acid_2862	6.415e-142	460.0	COG0577@1|root,COG0577@2|Bacteria,3Y3ZQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_2976898_14	234267.Acid_2861	4.94e-79	272.0	COG0457@1|root,COG0457@2|Bacteria,3Y4RD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HFD2_k127_2976898_32	1487953.JMKF01000043_gene2619	6.609e-19	96.0	COG0457@1|root,COG0457@2|Bacteria	1487953.JMKF01000043_gene2619|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_7	234267.Acid_6404	4.686e-101	342.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HFD2_k127_2976898_37	1267535.KB906767_gene5188	1.998e-09	61.0	COG3350@1|root,COG3350@2|Bacteria,3Y90F@57723|Acidobacteria	57723|Acidobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_28	383372.Rcas_2749	3.655e-31	139.0	COG5305@1|root,COG5305@2|Bacteria,2G7EE@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_30	639030.JHVA01000001_gene1884	3.327e-23	110.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_29	1340493.JNIF01000003_gene2122	2.955e-26	112.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2976898_21	56107.Cylst_0311	4.587e-51	194.0	COG3000@1|root,COG3000@2|Bacteria,1GAN0@1117|Cyanobacteria,1HQ2V@1161|Nostocales	1117|Cyanobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_2976898_31	1242864.D187_005899	2.501e-21	106.0	COG2175@1|root,COG2175@2|Bacteria,1R972@1224|Proteobacteria	1224|Proteobacteria	C	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HFD2_k127_2976898_11	671143.DAMO_0415	2.945e-85	289.0	COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2976898_5	671143.DAMO_0414	1.058e-122	409.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HFD2_k127_2976898_1	1340493.JNIF01000003_gene4022	4.904e-319	992.0	COG0531@1|root,COG0531@2|Bacteria,3Y2RG@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_2976898_6	1218076.BAYB01000003_gene624	4.037e-108	357.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VZKQ@28216|Betaproteobacteria,1KFEU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_2976898_16	630626.EBL_c13660	3.346e-74	255.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,1RYBU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Gentisate 1,2-dioxygenase	gtdA	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD2_k127_300453_0	204669.Acid345_2701	9.401e-90	304.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_3011204_15	234267.Acid_0484	1.221e-38	146.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_3011204_11	234267.Acid_0483	2.624e-51	184.0	COG0509@1|root,COG0509@2|Bacteria,3Y55C@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD2_k127_3011204_2	234267.Acid_0482	8.113e-207	650.0	COG0403@1|root,COG0403@2|Bacteria,3Y2WZ@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD2_k127_3011204_1	1267535.KB906767_gene1172	2.713e-237	743.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria,2JIAN@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD2_k127_3011204_13	1340493.JNIF01000003_gene1703	8.996e-50	187.0	COG0741@1|root,COG0741@2|Bacteria,3Y4SM@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD2_k127_3011204_10	1267535.KB906767_gene965	3.119e-60	221.0	COG4975@1|root,COG4975@2|Bacteria,3Y6YG@57723|Acidobacteria	57723|Acidobacteria	G	Ureide permease	-	-	-	ko:K05340	-	-	-	-	ko00000,ko02000	2.A.7.5	-	-	Ureide_permease
HFD2_k127_3011204_9	234267.Acid_3879	1.377e-81	275.0	COG1143@1|root,COG1143@2|Bacteria,3Y371@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HFD2_k127_3011204_5	234267.Acid_7361	2.072e-128	425.0	COG1807@1|root,COG1807@2|Bacteria,3Y6PY@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3011204_14	234267.Acid_3884	2.725e-41	155.0	COG1366@1|root,COG1366@2|Bacteria,3Y83J@57723|Acidobacteria	57723|Acidobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD2_k127_3011204_4	234267.Acid_2165	5.192e-137	452.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3Y6RV@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_3011204_6	1267535.KB906767_gene4267	3.714e-127	410.0	COG0745@1|root,COG0745@2|Bacteria,3Y522@57723|Acidobacteria,2JP4G@204432|Acidobacteriia	204432|Acidobacteriia	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3011204_8	1267535.KB906767_gene2417	7.148e-90	302.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria,2JI9M@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HFD2_k127_3011204_17	278963.ATWD01000001_gene3139	2.015e-26	115.0	COG4770@1|root,COG4770@2|Bacteria,3Y5QJ@57723|Acidobacteria,2JN6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HFD2_k127_3011204_3	1267535.KB906767_gene2419	2.382e-189	604.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria,2JKRD@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD2_k127_3011204_16	234267.Acid_0471	1.878e-36	140.0	COG1193@1|root,COG1193@2|Bacteria,3Y8PZ@57723|Acidobacteria	57723|Acidobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HFD2_k127_3011204_0	234267.Acid_5816	2.045e-291	911.0	COG0339@1|root,COG0339@2|Bacteria,3Y3U9@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase	-	-	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HFD2_k127_3011204_18	234267.Acid_5056	1.204e-10	69.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K07001	-	-	-	-	ko00000	-	-	-	DUF3376,Patatin
HFD2_k127_3011204_7	234267.Acid_2458	1.326e-110	361.0	COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria	57723|Acidobacteria	H	PFAM delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HFD2_k127_3018724_0	1121904.ARBP01000013_gene349	3.496e-151	489.0	COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia	976|Bacteroidetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_3018724_1	1340493.JNIF01000004_gene375	5.531e-87	305.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
HFD2_k127_3027805_0	234267.Acid_5729	7.825e-168	536.0	COG0577@1|root,COG0577@2|Bacteria,3Y3HB@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_3027805_2	1005048.CFU_3220	2.486e-135	445.0	COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2VIKS@28216|Betaproteobacteria,4791C@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Sugar (and other) transporter	pcaK	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4
HFD2_k127_3027805_1	1097668.BYI23_C002820	1.157e-137	445.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,1JZPS@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Gentisate 1,2-dioxygenase	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD2_k127_3045809_5	388413.ALPR1_16713	1.746e-10	66.0	COG3975@1|root,COG3975@2|Bacteria,4P0G5@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3045809_4	234267.Acid_6120	2.892e-15	79.0	2ANB8@1|root,31D9I@2|Bacteria,3Y8WC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3045809_2	1267535.KB906767_gene1212	2.404e-46	171.0	COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria	57723|Acidobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HFD2_k127_3045809_1	234267.Acid_6122	1.348e-140	451.0	2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
HFD2_k127_3045809_0	1267535.KB906767_gene1214	3.17e-160	518.0	COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria	57723|Acidobacteria	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HFD2_k127_3045809_3	1267535.KB906767_gene1218	1.13e-15	90.0	2DDV1@1|root,2ZJDR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3049849_3	1340493.JNIF01000003_gene4604	2.016e-113	374.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	DUF3500
HFD2_k127_3049849_5	1267535.KB906767_gene4647	1.148e-57	212.0	COG4449@1|root,COG4449@2|Bacteria,3Y84G@57723|Acidobacteria	57723|Acidobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HFD2_k127_3049849_9	234267.Acid_4092	1.398e-44	168.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_3049849_6	234267.Acid_4093	1.94e-57	211.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_3049849_7	1340493.JNIF01000003_gene1338	3.371e-53	198.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_3049849_1	234267.Acid_0040	1.227e-202	635.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_3049849_12	234267.Acid_6765	1.415e-28	119.0	COG1314@1|root,COG1314@2|Bacteria,3Y56S@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HFD2_k127_3049849_4	1267535.KB906767_gene3395	8.098e-58	204.0	COG1733@1|root,COG1733@2|Bacteria,3Y7XV@57723|Acidobacteria,2JN1Y@204432|Acidobacteriia	204432|Acidobacteriia	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD2_k127_3049849_0	1267535.KB906767_gene3396	3.887e-224	696.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD2_k127_3049849_8	1267535.KB906767_gene3397	4.367e-45	169.0	COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria,2JJVU@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3049849_10	247633.GP2143_17796	1.053e-36	152.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3049849_2	1123277.KB893185_gene3031	2.764e-131	435.0	COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,47MRG@768503|Cytophagia	976|Bacteroidetes	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_3049849_11	234267.Acid_3097	2.035e-29	125.0	COG4993@1|root,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_3060436_3	1267535.KB906767_gene2661	1.521e-90	302.0	COG1573@1|root,COG1573@2|Bacteria,3Y4AT@57723|Acidobacteria,2JJ4U@204432|Acidobacteriia	204432|Acidobacteriia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_3060436_1	234267.Acid_2556	2.253e-183	582.0	COG2252@1|root,COG2252@2|Bacteria,3Y2I3@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HFD2_k127_3060436_0	234267.Acid_0019	1.157e-246	779.0	2EY4D@1|root,33RD9@2|Bacteria,3Y6DM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3060436_2	234267.Acid_0020	1.032e-164	547.0	COG0457@1|root,COG0457@2|Bacteria,3Y6VN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3060436_5	1340493.JNIF01000003_gene4796	2.736e-44	173.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HDOD,Response_reg
HFD2_k127_3060436_4	266117.Rxyl_0933	2.258e-89	306.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria,4CRDV@84995|Rubrobacteria	84995|Rubrobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_3060436_6	204669.Acid345_3487	2.477e-28	115.0	COG3279@1|root,COG3279@2|Bacteria,3Y3B3@57723|Acidobacteria,2JP1W@204432|Acidobacteriia	204432|Acidobacteriia	KT	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_3104832_4	1340493.JNIF01000004_gene1007	3.31e-60	212.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD2_k127_3104832_0	1340493.JNIF01000004_gene1008	1.937e-172	554.0	COG1207@1|root,COG1207@2|Bacteria,3Y3SI@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HFD2_k127_3104832_2	234267.Acid_4363	6.864e-117	385.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria	57723|Acidobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HFD2_k127_3104832_3	234267.Acid_3789	1.727e-97	328.0	COG2971@1|root,COG2971@2|Bacteria,3Y2J3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD2_k127_3104832_1	234267.Acid_6258	2.952e-171	563.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	DUF3367,PMT_2
HFD2_k127_3146738_1	1312954.KI914885_gene2646	3.115e-180	574.0	28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3146738_0	1340493.JNIF01000004_gene88	5.967e-272	877.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD2_k127_3146738_2	929703.KE386491_gene2730	5.851e-95	321.0	COG0578@1|root,COG0578@2|Bacteria,4NEYG@976|Bacteroidetes,47MN6@768503|Cytophagia	976|Bacteroidetes	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HFD2_k127_3174589_2	1267535.KB906767_gene5132	6.607e-164	548.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_3174589_8	330214.NIDE4311	7.1e-38	147.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
HFD2_k127_3174589_3	330214.NIDE4312	2.868e-135	437.0	COG0330@1|root,COG0330@2|Bacteria,3J0NF@40117|Nitrospirae	40117|Nitrospirae	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_3174589_5	1380391.JIAS01000017_gene475	2.394e-80	299.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDS@28211|Alphaproteobacteria,2JZ03@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_3174589_0	1340493.JNIF01000004_gene819	1.374e-259	822.0	COG4654@1|root,COG4654@2|Bacteria	2|Bacteria	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD2_k127_3174589_1	1340493.JNIF01000004_gene818	9.632e-194	620.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_3174589_14	1267535.KB906767_gene1470	3.086e-10	67.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	gcd2	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_3174589_11	1335760.ASTG01000003_gene1749	8.162e-27	114.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria,2UJHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3174589_6	1283299.AUKG01000002_gene4438	5.013e-60	221.0	28JPR@1|root,2Z9FQ@2|Bacteria,2H4H9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3174589_9	909613.UO65_0490	1.747e-36	146.0	COG1011@1|root,COG1011@2|Bacteria,2H639@201174|Actinobacteria	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_3174589_4	1121468.AUBR01000011_gene2488	1.183e-124	414.0	COG0207@1|root,COG0207@2|Bacteria,1VNVD@1239|Firmicutes,24ZUI@186801|Clostridia	186801|Clostridia	F	Thymidylate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Thymidylat_synt
HFD2_k127_3202667_7	1340493.JNIF01000003_gene4275	6.83e-28	129.0	COG1629@1|root,COG4771@2|Bacteria,3Y6PD@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_3202667_2	1340493.JNIF01000003_gene3658	1.095e-86	300.0	COG1240@1|root,COG1240@2|Bacteria,3Y474@57723|Acidobacteria	57723|Acidobacteria	H	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HFD2_k127_3202667_5	234267.Acid_1403	9.552e-50	182.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM molybdenum cofactor synthesis	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD2_k127_3202667_4	234267.Acid_1404	5.966e-62	220.0	COG0315@1|root,COG0315@2|Bacteria,3Y4IY@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HFD2_k127_3202667_0	234267.Acid_1405	6.393e-147	475.0	COG0303@1|root,COG0303@2|Bacteria,3Y3F0@57723|Acidobacteria	57723|Acidobacteria	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD2_k127_3202667_1	1340493.JNIF01000003_gene4449	1.27e-110	363.0	COG1692@1|root,COG1692@2|Bacteria	2|Bacteria	S	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
HFD2_k127_3202667_3	344747.PM8797T_06150	2.532e-79	278.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3202667_9	237368.SCABRO_02025	1.029e-13	73.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3202667_6	1340493.JNIF01000003_gene2348	6.835e-43	165.0	COG3620@1|root,COG3620@2|Bacteria,3Y8HY@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD2_k127_3202667_8	1267533.KB906742_gene729	1.871e-19	89.0	2C51Y@1|root,33J3U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3207959_1	1265313.HRUBRA_01849	1.782e-140	458.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ_2
HFD2_k127_3207959_3	204669.Acid345_1281	1.858e-43	163.0	COG0393@1|root,COG0393@2|Bacteria,3Y50H@57723|Acidobacteria,2JJIZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HFD2_k127_3207959_0	1267535.KB906767_gene1751	0.0	1028.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria,2JI5F@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HFD2_k127_3207959_5	1267535.KB906767_gene1750	1.348e-31	125.0	COG0184@1|root,COG0184@2|Bacteria,3Y5R5@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal_S15	-	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD2_k127_3207959_6	682795.AciX8_4786	1.172e-23	108.0	COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria,2JN7M@204432|Acidobacteriia	204432|Acidobacteriia	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_3207959_2	1267535.KB906767_gene4032	1.719e-67	235.0	COG1434@1|root,COG1434@2|Bacteria,3Y4FT@57723|Acidobacteria,2JJ4K@204432|Acidobacteriia	204432|Acidobacteriia	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD2_k127_3207959_4	1340493.JNIF01000003_gene2414	9.216e-40	153.0	COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_3215009_7	1340493.JNIF01000003_gene3432	1.185e-89	325.0	COG1629@1|root,COG1629@2|Bacteria,3Y765@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_3215009_3	234267.Acid_7932	1.93e-123	400.0	COG0613@1|root,COG0613@2|Bacteria,3Y5C1@57723|Acidobacteria	57723|Acidobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HFD2_k127_3215009_8	1128421.JAGA01000004_gene2603	2.38e-66	230.0	COG0529@1|root,COG0529@2|Bacteria,2NPBJ@2323|unclassified Bacteria	2|Bacteria	P	Catalyzes the synthesis of activated sulfate	cysC	GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564	1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4	ko:K00390,ko:K00860,ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R02021,R04928,R04929	RC00002,RC00007,RC00078,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HFD2_k127_3215009_2	1267535.KB906767_gene1538	8.456e-156	507.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863,FG-GAP,PQQ_2,VCBS,fn3
HFD2_k127_3215009_13	391613.RTM1035_00650	0.0003683	45.0	2ECEU@1|root,319CF@2|Bacteria,1Q2BF@1224|Proteobacteria,2V9QZ@28211|Alphaproteobacteria,46R48@74030|Roseovarius	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3215009_12	1192034.CAP_5211	1.709e-10	68.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_3215009_11	710111.FraQA3DRAFT_4205	7.426e-14	77.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DUF3099,DnaJ
HFD2_k127_3215009_10	1267534.KB906757_gene928	9.076e-19	93.0	2C9TJ@1|root,2ZFZD@2|Bacteria,3Y970@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3215009_0	234267.Acid_5749	9.937e-216	699.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_3215009_6	344747.PM8797T_06150	2.371e-107	364.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3215009_1	234267.Acid_5827	3.037e-200	650.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_3215009_4	1340493.JNIF01000003_gene3475	6.701e-112	377.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_3215009_9	1340493.JNIF01000003_gene3476	1.184e-65	249.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	moxJ	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,SBP_bac_3
HFD2_k127_3215009_5	234267.Acid_7430	2.034e-108	359.0	COG0604@1|root,COG0604@2|Bacteria,3Y35U@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_3265714_9	234267.Acid_1835	1.446e-91	308.0	COG0531@1|root,COG0531@2|Bacteria,3Y4PR@57723|Acidobacteria	57723|Acidobacteria	E	PFAM amino acid permease-associated region	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HFD2_k127_3265714_5	234267.Acid_5660	1.127e-154	499.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria	57723|Acidobacteria	H	Mur ligase, middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_3265714_14	1267535.KB906767_gene3783	1.033e-65	233.0	COG0204@1|root,COG0204@2|Bacteria,3Y4EM@57723|Acidobacteria,2JJ6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_3265714_21	760192.Halhy_0468	6.254e-44	165.0	2DMP1@1|root,32SS8@2|Bacteria,4NQY9@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the UPF0311 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
HFD2_k127_3265714_6	1340493.JNIF01000004_gene206	8.942e-114	380.0	COG4963@1|root,COG4963@2|Bacteria,3Y44H@57723|Acidobacteria	2|Bacteria	U	AAA domain	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
HFD2_k127_3265714_13	1340493.JNIF01000004_gene207	8.015e-73	252.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_3265714_24	234267.Acid_7241	3.473e-21	103.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_3265714_2	234267.Acid_5819	4.313e-200	641.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3265714_4	234267.Acid_5820	9.667e-158	518.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3265714_1	1267535.KB906767_gene2548	5.719e-230	735.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria,2JI5V@204432|Acidobacteriia	204432|Acidobacteriia	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
HFD2_k127_3265714_0	357808.RoseRS_2569	1.622e-265	825.0	COG2368@1|root,COG2368@2|Bacteria,2G7XE@200795|Chloroflexi,3764P@32061|Chloroflexia	32061|Chloroflexia	Q	PFAM 4-hydroxyphenylacetate 3-hydroxylase	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
HFD2_k127_3265714_10	497964.CfE428DRAFT_0230	3.19e-76	276.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,46TGZ@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_3265714_19	208444.JNYY01000004_gene2076	1.207e-46	179.0	COG2755@1|root,COG2755@2|Bacteria,2GYQF@201174|Actinobacteria	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_3265714_22	1267535.KB906767_gene2090	1.483e-37	143.0	COG0599@1|root,COG0599@2|Bacteria,3Y60M@57723|Acidobacteria,2JNVN@204432|Acidobacteriia	204432|Acidobacteriia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_3265714_7	643473.KB235930_gene4498	1.294e-101	341.0	COG0604@1|root,COG0604@2|Bacteria,1G241@1117|Cyanobacteria,1HJUC@1161|Nostocales	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_3265714_18	485913.Krac_4134	1.123e-52	197.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HFD2_k127_3265714_20	627192.SLG_09880	1.086e-44	172.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2VG0A@28211|Alphaproteobacteria,2KBBC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3265714_8	1340493.JNIF01000004_gene785	2.902e-101	341.0	COG0115@1|root,COG0115@2|Bacteria,3Y6HY@57723|Acidobacteria	57723|Acidobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_3265714_11	234267.Acid_7668	1.102e-74	255.0	COG3605@1|root,COG3605@2|Bacteria,3Y7TF@57723|Acidobacteria	57723|Acidobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
HFD2_k127_3265714_25	1267535.KB906767_gene4197	3.905e-18	91.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_3265714_15	234267.Acid_7860	1.477e-65	229.0	COG1595@1|root,COG1595@2|Bacteria,3Y4FY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_3265714_17	234267.Acid_7861	1.479e-54	201.0	COG5343@1|root,COG5343@2|Bacteria,3Y4J0@57723|Acidobacteria	57723|Acidobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_3265714_12	1267535.KB906767_gene3053	3.433e-73	275.0	COG4995@1|root,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD2_k127_3265714_16	1267535.KB906767_gene3052	1.747e-65	241.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Y7@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3265714_3	234267.Acid_6397	1.501e-187	598.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
HFD2_k127_3274698_3	204669.Acid345_4263	1.358e-18	90.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria,2JK3G@204432|Acidobacteriia	204432|Acidobacteriia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
HFD2_k127_3274698_0	1382303.JPOM01000001_gene1745	7.124e-159	522.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2KF9M@204458|Caulobacterales	204458|Caulobacterales	CG	PQQ-like domain	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ
HFD2_k127_3274698_2	136993.KB900627_gene392	3.561e-25	116.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3274698_1	278963.ATWD01000002_gene840	1.534e-107	349.0	COG2141@1|root,COG2141@2|Bacteria,3Y6F5@57723|Acidobacteria,2JHT3@204432|Acidobacteriia	204432|Acidobacteriia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3293667_1	1267535.KB906767_gene4824	1.113e-87	291.0	COG0332@1|root,COG0332@2|Bacteria,3Y2Z5@57723|Acidobacteria,2JIAW@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD2_k127_3293667_0	1340493.JNIF01000003_gene2565	1.102e-91	308.0	COG3842@1|root,COG3842@2|Bacteria,3Y4Q4@57723|Acidobacteria	57723|Acidobacteria	P	TOBE domain	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HFD2_k127_3299802_1	1288963.ADIS_4385	5.331e-200	629.0	COG1063@1|root,COG1063@2|Bacteria,4NIU2@976|Bacteroidetes,47MH0@768503|Cytophagia	976|Bacteroidetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_3299802_0	1267535.KB906767_gene4512	6.467e-317	989.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_3299802_2	1267535.KB906767_gene4512	3.568e-34	140.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_3334747_7	472759.Nhal_0268	3.362e-17	84.0	COG2336@1|root,COG2336@2|Bacteria,1N9Z6@1224|Proteobacteria,1SDVP@1236|Gammaproteobacteria,1WZMC@135613|Chromatiales	135613|Chromatiales	T	SpoVT / AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HFD2_k127_3334747_6	340177.Cag_0429	5.935e-39	152.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	chpA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD2_k127_3334747_5	292415.Tbd_1308	2.599e-66	230.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VRBM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD2_k127_3334747_2	234267.Acid_6218	1.842e-100	336.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_3334747_0	234267.Acid_7266	1.852e-121	396.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD2_k127_3334747_1	234267.Acid_7265	3.198e-107	356.0	COG0564@1|root,COG0564@2|Bacteria,3Y3G8@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_3334747_4	234267.Acid_1432	9.557e-81	278.0	COG0500@1|root,COG2226@2|Bacteria,3Y7N3@57723|Acidobacteria	57723|Acidobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
HFD2_k127_3334747_3	1267535.KB906767_gene5455	1.195e-81	274.0	COG2021@1|root,COG2021@2|Bacteria,3Y4EW@57723|Acidobacteria,2JMVK@204432|Acidobacteriia	204432|Acidobacteriia	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_3338126_6	234267.Acid_2377	8.473e-11	64.0	COG0388@1|root,COG0388@2|Bacteria,3Y7FJ@57723|Acidobacteria	57723|Acidobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_3338126_3	234267.Acid_2377	6.119e-39	148.0	COG0388@1|root,COG0388@2|Bacteria,3Y7FJ@57723|Acidobacteria	57723|Acidobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_3338126_0	234267.Acid_0873	2.973e-206	663.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_3338126_2	216594.MMAR_0242	4.293e-53	199.0	COG0657@1|root,COG0823@1|root,COG0657@2|Bacteria,COG0823@2|Bacteria,2I40M@201174|Actinobacteria,233DD@1762|Mycobacteriaceae	201174|Actinobacteria	U	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE
HFD2_k127_3338126_1	1038859.AXAU01000017_gene6271	2.864e-129	421.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,2UPRH@28211|Alphaproteobacteria,3K2ZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_3338126_5	555793.WSK_4047	6.745e-27	123.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3338126_4	298654.FraEuI1c_4079	3.663e-30	128.0	28JDP@1|root,32SV2@2|Bacteria,2IPQY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_339026_2	316274.Haur_3093	2.895e-12	71.0	COG0745@1|root,COG0745@2|Bacteria	316274.Haur_3093|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_339026_1	324602.Caur_1860	6.685e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_339026_3	1382306.JNIM01000001_gene756	7.122e-11	72.0	COG5343@1|root,COG5343@2|Bacteria,2G7H8@200795|Chloroflexi	200795|Chloroflexi	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_339026_0	765420.OSCT_1974	4.295e-55	203.0	2BBY6@1|root,325GN@2|Bacteria,2G746@200795|Chloroflexi,375WM@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_4	136993.KB900627_gene392	2.429e-33	136.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_12	1340493.JNIF01000003_gene2122	1.247e-27	117.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_6	264732.Moth_0417	3.773e-31	141.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	kdgR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_3436061_3	234267.Acid_7400	2.059e-36	145.0	COG2318@1|root,COG2318@2|Bacteria,3Y8J8@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_3436061_7	136993.KB900627_gene392	6.667e-31	132.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_11	1382359.JIAL01000001_gene178	2.091e-28	124.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_3436061_10	1340493.JNIF01000003_gene2123	4.173e-29	133.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_14	639030.JHVA01000001_gene1884	2.561e-24	118.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_9	639030.JHVA01000001_gene1885	2.989e-29	121.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_0	1340493.JNIF01000004_gene920	7.183e-207	671.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5
HFD2_k127_3436061_13	136993.KB900627_gene392	2.019e-27	124.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_8	234267.Acid_1920	7.64e-30	121.0	2DQUE@1|root,338R6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3436061_1	234267.Acid_2032	1.476e-114	384.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_3436061_2	886293.Sinac_1155	1.77e-64	239.0	COG0666@1|root,COG0666@2|Bacteria,2J1F8@203682|Planctomycetes	203682|Planctomycetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD2_k127_3436061_5	1267535.KB906767_gene4540	1.678e-31	130.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
HFD2_k127_34454_0	443143.GM18_1319	5.324e-254	802.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HFD2_k127_34454_1	1122603.ATVI01000007_gene1764	8.643e-14	81.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_8
HFD2_k127_3454129_2	1424334.W822_22580	7.337e-79	281.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_3454129_4	671143.DAMO_1282	1.44e-68	235.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	celM	-	3.2.1.4	ko:K01179,ko:K20276	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	F5_F8_type_C,Glyco_hydro_44,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
HFD2_k127_3454129_3	1121015.N789_02195	3.43e-76	260.0	COG3291@1|root,COG3291@2|Bacteria,1R2FS@1224|Proteobacteria	1224|Proteobacteria	S	Glycoside hydrolase family 44	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_44
HFD2_k127_3454129_5	1121920.AUAU01000019_gene2557	6.52e-18	98.0	COG5434@1|root,COG5492@1|root,COG5434@2|Bacteria,COG5492@2|Bacteria,3Y4WD@57723|Acidobacteria	57723|Acidobacteria	N	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3454129_0	671143.DAMO_0158	1.253e-124	417.0	COG4409@1|root,COG4409@2|Bacteria,2NQRQ@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
HFD2_k127_3454129_1	1247726.MIM_c02340	8.13e-105	362.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_3454129_6	1082933.MEA186_13018	1.762e-12	70.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2	rutB	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD2_k127_3463009_4	1267535.KB906767_gene2562	9.441e-59	211.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_3463009_3	234267.Acid_7313	6.636e-149	503.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_3463009_1	1340493.JNIF01000003_gene3728	2.466e-165	527.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria	57723|Acidobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD2_k127_3463009_2	234267.Acid_7315	5.995e-156	506.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria	57723|Acidobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_3463009_0	234267.Acid_7316	3.947e-201	639.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_3463009_5	234267.Acid_7317	2.897e-06	49.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HFD2_k127_3465242_2	234267.Acid_3586	1.541e-94	341.0	COG1404@1|root,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	57723|Acidobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_3465242_3	1267535.KB906767_gene1125	4.16e-85	288.0	COG0284@1|root,COG0284@2|Bacteria,3Y2XD@57723|Acidobacteria,2JIQY@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HFD2_k127_3465242_1	234267.Acid_4783	5.846e-171	548.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_3465242_0	1340493.JNIF01000003_gene3872	2.142e-204	646.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
HFD2_k127_3506625_1	1267535.KB906767_gene3083	1.708e-91	333.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_3506625_2	1340493.JNIF01000003_gene1551	2.472e-32	133.0	COG2318@1|root,COG2318@2|Bacteria,3Y503@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_3506625_0	234267.Acid_7637	6.151e-193	627.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_3508121_0	204669.Acid345_3335	3.792e-173	554.0	COG2206@1|root,COG5000@1|root,COG2206@2|Bacteria,COG5000@2|Bacteria,3Y7I5@57723|Acidobacteria,2JMTE@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HFD2_k127_3508121_1	1120792.JAFV01000001_gene2343	1.28e-134	447.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3700Y@31993|Methylocystaceae	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.2.3,1.1.3.46,1.13.12.4	ko:K00101,ko:K00467,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R00319,R06633	RC00044,RC00240,RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_3513462_8	479434.Sthe_1132	2.216e-37	151.0	COG0297@1|root,COG0438@1|root,COG0726@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,COG0726@2|Bacteria,2G8HZ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD2_k127_3513462_4	671143.DAMO_2345	1.059e-126	413.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	lspL	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_3513462_7	1267535.KB906767_gene5406	2.732e-61	223.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD2_k127_3513462_6	686340.Metal_0327	1.601e-78	279.0	COG0438@1|root,COG0438@2|Bacteria,1QTH7@1224|Proteobacteria,1RXHP@1236|Gammaproteobacteria,1XFTD@135618|Methylococcales	135618|Methylococcales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD2_k127_3513462_5	644282.Deba_0179	7.072e-111	366.0	COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_3513462_3	335543.Sfum_1046	5.179e-184	583.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2MR3M@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HFD2_k127_3513462_2	1535287.JP74_20660	1.233e-254	823.0	2CCM7@1|root,33RDG@2|Bacteria,1QZTA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3513462_1	494419.ALPM01000091_gene438	6.938e-317	1011.0	28MJW@1|root,2ZAW9@2|Bacteria,2H1U8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3513462_0	494419.ALPM01000091_gene439	0.0	2209.0	COG2885@1|root,COG2885@2|Bacteria,2IBAR@201174|Actinobacteria	201174|Actinobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3513462_9	344747.PM8797T_21853	1.689e-20	93.0	COG2159@1|root,COG2159@2|Bacteria,2IZCY@203682|Planctomycetes	203682|Planctomycetes	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD2_k127_3528771_0	1037409.BJ6T_42530	1.317e-145	482.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_3528771_3	234267.Acid_1337	1.364e-58	212.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase
HFD2_k127_3528771_5	883080.HMPREF9697_02846	4.677e-49	180.0	COG1898@1|root,COG1898@2|Bacteria,1NCF0@1224|Proteobacteria,2UG3Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD2_k127_3528771_2	883080.HMPREF9697_02847	6.536e-66	234.0	COG2301@1|root,COG2301@2|Bacteria,1RJQ8@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_3528771_4	234267.Acid_0562	1.151e-49	198.0	2F5D3@1|root,33XZ2@2|Bacteria	2|Bacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
HFD2_k127_3528771_6	1123508.JH636439_gene1513	1.647e-20	104.0	COG3386@1|root,COG3386@2|Bacteria,2IXWY@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_3528771_1	234267.Acid_7271	2.972e-123	407.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD2_k127_3538221_2	1267535.KB906767_gene4262	2.216e-135	446.0	COG2271@1|root,COG2271@2|Bacteria,3Y6AJ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3538221_6	1968.JOEV01000041_gene13	1.826e-54	202.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
HFD2_k127_3538221_9	234267.Acid_1140	1.896e-22	98.0	COG4980@1|root,COG4980@2|Bacteria,3Y8W2@57723|Acidobacteria	57723|Acidobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
HFD2_k127_3538221_5	497964.CfE428DRAFT_5441	3.886e-99	337.0	COG0477@1|root,COG2814@2|Bacteria,46UNQ@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3538221_11	743836.AYNA01000114_gene844	4.525e-14	77.0	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2U5M2@28211|Alphaproteobacteria,36ZY0@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_3538221_1	234267.Acid_3680	1.574e-204	667.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_3538221_7	221288.JH992901_gene1687	3.534e-36	139.0	COG1695@1|root,COG1695@2|Bacteria,1GDRG@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_3538221_3	234267.Acid_5886	9.606e-126	416.0	COG1538@1|root,COG1538@2|Bacteria,3Y3KB@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_3538221_0	401053.AciPR4_2695	0.0	1364.0	COG0841@1|root,COG0841@2|Bacteria,3Y309@57723|Acidobacteria,2JKM2@204432|Acidobacteriia	204432|Acidobacteriia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_3538221_4	1267535.KB906767_gene2008	2.108e-102	345.0	COG0845@1|root,COG0845@2|Bacteria,3Y2U2@57723|Acidobacteria,2JMFW@204432|Acidobacteriia	204432|Acidobacteriia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_3560978_6	1340493.JNIF01000003_gene1292	5.951e-23	114.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,PMT_2
HFD2_k127_3560978_4	1267535.KB906767_gene781	2.459e-71	261.0	COG0457@1|root,COG0457@2|Bacteria,3Y7TN@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3560978_2	1340493.JNIF01000003_gene1290	5.775e-117	387.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784,ko:K13318,ko:K13322,ko:K16439,ko:K19857	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793,M00798,M00799,M00800	R00291,R02984,R06436,R06513,R06629,R11042,R11047	RC00182,RC00261,RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_3560978_3	234267.Acid_1803	7.591e-75	262.0	COG0500@1|root,COG2226@2|Bacteria,3Y8WR@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_3560978_0	1535287.JP74_04850	4.645e-144	465.0	COG3836@1|root,COG3836@2|Bacteria,1P861@1224|Proteobacteria	1224|Proteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_3560978_5	240015.ACP_1197	3.324e-59	214.0	COG0500@1|root,COG0500@2|Bacteria,3Y7UI@57723|Acidobacteria,2JN58@204432|Acidobacteriia	204432|Acidobacteriia	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_3560978_1	234267.Acid_6265	1.278e-130	432.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_3590522_1	1267534.KB906754_gene3469	5.438e-59	214.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XC@57723|Acidobacteria,2JJ0F@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_3590522_2	1267535.KB906767_gene5204	2.04e-39	149.0	COG1695@1|root,COG1695@2|Bacteria,3Y7SR@57723|Acidobacteria	57723|Acidobacteria	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_3590522_3	1267535.KB906767_gene5200	4.016e-32	129.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rpbA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_3590522_0	1267535.KB906767_gene316	7.934e-193	613.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD2_k127_3599654_0	1267535.KB906767_gene823	4.107e-253	795.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD2_k127_3599654_2	234267.Acid_3860	1.59e-45	178.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3599654_3	861299.J421_3660	2.811e-21	108.0	2E98K@1|root,333GZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3599654_1	449447.MAE_41970	3.585e-55	202.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	DUF4214,HTH_3,Methyltransf_11,Methyltransf_21,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_3614072_0	861299.J421_4036	8.323e-224	710.0	COG4774@1|root,COG4774@2|Bacteria,1ZTSY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,TonB_dep_Rec
HFD2_k127_3614072_7	1267534.KB906761_gene1211	1.914e-44	176.0	COG1228@1|root,COG1228@2|Bacteria,3Y4IP@57723|Acidobacteria,2JMQC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_3614072_11	1267535.KB906767_gene1485	4.075e-21	102.0	COG0291@1|root,COG0291@2|Bacteria,3Y5GU@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HFD2_k127_3614072_6	1267535.KB906767_gene1486	8.04e-48	173.0	COG0292@1|root,COG0292@2|Bacteria,3Y4SW@57723|Acidobacteria,2JJJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HFD2_k127_3614072_12	234267.Acid_1221	2.862e-20	97.0	COG3027@1|root,COG3027@2|Bacteria,3Y8Q5@57723|Acidobacteria	57723|Acidobacteria	D	Cell division protein ZapA	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HFD2_k127_3614072_4	234267.Acid_3780	2.464e-52	192.0	COG1496@1|root,COG1496@2|Bacteria,3Y3J1@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HFD2_k127_3614072_5	1267535.KB906767_gene4881	3.656e-51	184.0	COG1734@1|root,COG1734@2|Bacteria,3Y85W@57723|Acidobacteria	57723|Acidobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD2_k127_3614072_2	234267.Acid_5860	3.499e-89	314.0	COG1807@1|root,COG1807@2|Bacteria,3Y7PC@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3614072_1	1340493.JNIF01000004_gene178	1.081e-107	381.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,Reprolysin_3
HFD2_k127_3614072_8	1267535.KB906767_gene424	4.461e-36	141.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD2_k127_3614072_3	935840.JAEQ01000023_gene4306	7.707e-57	202.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U7NJ@28211|Alphaproteobacteria,43R40@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_3614072_10	1040989.AWZU01000007_gene736	8.198e-25	114.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_3622142_8	1123368.AUIS01000004_gene153	2.23e-12	76.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,2NCJU@225057|Acidithiobacillales	225057|Acidithiobacillales	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
HFD2_k127_3622142_5	234267.Acid_5382	4.165e-39	152.0	2FC4E@1|root,3448B@2|Bacteria,3Y8HE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3622142_3	1267535.KB906767_gene4961	2.962e-59	211.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HFD2_k127_3622142_6	234267.Acid_5380	5.079e-28	119.0	COG4233@1|root,COG4233@2|Bacteria,3Y9AX@57723|Acidobacteria	57723|Acidobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
HFD2_k127_3622142_2	234267.Acid_0378	7.279e-77	265.0	COG0859@1|root,COG0859@2|Bacteria,3Y7R7@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HFD2_k127_3622142_0	485913.Krac_5620	1.175e-117	386.0	28HGI@1|root,2Z7SC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3622142_4	401053.AciPR4_4209	5.204e-45	164.0	COG5207@1|root,COG5207@2|Bacteria,3Y5QE@57723|Acidobacteria	57723|Acidobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HFD2_k127_3622142_1	395965.Msil_1617	1.529e-114	382.0	COG0596@1|root,COG0596@2|Bacteria,1QXD5@1224|Proteobacteria,2UNNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3622142_7	1380394.JADL01000001_gene3095	2.69e-22	102.0	COG0406@1|root,COG0406@2|Bacteria,1QVCI@1224|Proteobacteria	1224|Proteobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_3640609_10	234267.Acid_0331	1.55e-71	250.0	COG1360@1|root,COG1360@2|Bacteria,3Y4KZ@57723|Acidobacteria	57723|Acidobacteria	N	PFAM OmpA	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HFD2_k127_3640609_8	1267535.KB906767_gene3603	1.657e-90	306.0	COG1291@1|root,COG1291@2|Bacteria,3Y2VA@57723|Acidobacteria,2JIDW@204432|Acidobacteriia	204432|Acidobacteriia	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HFD2_k127_3640609_18	234267.Acid_0333	2.854e-20	94.0	COG1582@1|root,COG1582@2|Bacteria,3Y5M5@57723|Acidobacteria	57723|Acidobacteria	N	PFAM flagellar FlbD family protein	-	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
HFD2_k127_3640609_14	234267.Acid_5365	6.364e-40	159.0	COG1868@1|root,COG1868@2|Bacteria,3Y49R@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
HFD2_k127_3640609_9	1267535.KB906767_gene4598	1.724e-78	272.0	COG1344@1|root,COG1344@2|Bacteria,3Y4AW@57723|Acidobacteria	57723|Acidobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HFD2_k127_3640609_12	234267.Acid_0330	1.246e-50	198.0	COG1345@1|root,COG1345@2|Bacteria,3Y84M@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar hook-associated protein 2 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FliD_C,FliD_N
HFD2_k127_3640609_15	234267.Acid_0337	1.418e-33	139.0	COG1815@1|root,COG1815@2|Bacteria,3Y5BH@57723|Acidobacteria	57723|Acidobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
HFD2_k127_3640609_11	1267535.KB906767_gene4605	8.474e-61	212.0	COG1558@1|root,COG1558@2|Bacteria,3Y538@57723|Acidobacteria,2JJF1@204432|Acidobacteriia	204432|Acidobacteriia	N	flagellar basal-body rod protein FlgC	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD2_k127_3640609_21	1267535.KB906767_gene4606	9.905e-16	84.0	COG1677@1|root,COG1677@2|Bacteria,3Y5YZ@57723|Acidobacteria,2JK54@204432|Acidobacteriia	204432|Acidobacteriia	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
HFD2_k127_3640609_2	234267.Acid_0340	5.563e-151	495.0	COG1766@1|root,COG1766@2|Bacteria,3Y2HU@57723|Acidobacteria	57723|Acidobacteria	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
HFD2_k127_3640609_6	234267.Acid_0341	5.546e-102	342.0	COG1536@1|root,COG1536@2|Bacteria,3Y2U7@57723|Acidobacteria	57723|Acidobacteria	N	flagellar motor switch protein FliG	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
HFD2_k127_3640609_20	639030.JHVA01000001_gene436	8.031e-17	88.0	COG1317@1|root,COG1317@2|Bacteria,3Y5C3@57723|Acidobacteria,2JJQT@204432|Acidobacteriia	204432|Acidobacteriia	N	Flagellar assembly protein FliH	-	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
HFD2_k127_3640609_1	234267.Acid_0343	1.413e-190	605.0	COG1157@1|root,COG1157@2|Bacteria,3Y32E@57723|Acidobacteria	57723|Acidobacteria	NU	TIGRFAM ATPase, FliI YscN family	-	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD2_k127_3640609_16	234267.Acid_0270	1.484e-31	141.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,TPR_12,TPR_7,TPR_8
HFD2_k127_3640609_5	234267.Acid_6335	1.093e-109	366.0	COG2706@1|root,COG2706@2|Bacteria,3Y4KD@57723|Acidobacteria	57723|Acidobacteria	G	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
HFD2_k127_3640609_4	330214.NIDE0303	3.288e-114	387.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD2_k127_3640609_19	1340493.JNIF01000003_gene3114	5.723e-18	91.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD2_k127_3640609_7	1123023.JIAI01000013_gene4027	4.964e-98	333.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HFD2_k127_3640609_13	330214.NIDE3769	3.778e-42	164.0	COG0529@1|root,COG0529@2|Bacteria	2|Bacteria	P	adenylylsulfate kinase activity	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HFD2_k127_3640609_3	330214.NIDE3770	2.087e-114	379.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_3640609_17	1086011.HJ01_03285	3.373e-29	128.0	COG0589@1|root,COG0589@2|Bacteria,4NJ0H@976|Bacteroidetes,1I0HV@117743|Flavobacteriia	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_3640609_23	159087.Daro_1760	3.511e-09	67.0	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria	28216|Betaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_3640609_0	1125863.JAFN01000001_gene1462	1.161e-272	850.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HFD2_k127_3662152_3	1120951.AUBG01000001_gene870	1.226e-07	54.0	COG2120@1|root,COG2120@2|Bacteria,4NM6J@976|Bacteroidetes,1I57Z@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_3662152_0	1408473.JHXO01000008_gene2652	1.485e-174	554.0	COG0438@1|root,COG0438@2|Bacteria,4NKIM@976|Bacteroidetes	976|Bacteroidetes	M	Pfam Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD2_k127_3662152_1	1408473.JHXO01000008_gene2651	1.393e-156	503.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
HFD2_k127_3683060_1	234267.Acid_7637	9.043e-66	227.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_3683060_0	589865.DaAHT2_2428	3.83e-73	269.0	COG0685@1|root,COG0685@2|Bacteria,1NB3G@1224|Proteobacteria,42P1W@68525|delta/epsilon subdivisions,2WKDD@28221|Deltaproteobacteria,2MJ0X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
HFD2_k127_3683060_2	675635.Psed_2102	3.951e-53	192.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4DX7E@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
HFD2_k127_3692551_1	234267.Acid_7463	3.154e-59	218.0	COG1684@1|root,COG1684@2|Bacteria,3Y8C9@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial export proteins, family 1	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
HFD2_k127_3692551_2	234267.Acid_7462	8.322e-28	121.0	COG1987@1|root,COG1987@2|Bacteria,3Y5NJ@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial export proteins, family 3	-	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HFD2_k127_3692551_0	234267.Acid_7461	1.364e-88	303.0	COG1338@1|root,COG1338@2|Bacteria,3Y3K4@57723|Acidobacteria	57723|Acidobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
HFD2_k127_3692551_4	234267.Acid_7460	1.505e-10	65.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
HFD2_k127_3692551_3	1340493.JNIF01000003_gene3253	4.175e-14	73.0	COG1886@1|root,COG1886@2|Bacteria	2|Bacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C,FliN_N
HFD2_k127_3719539_0	1267535.KB906767_gene4145	6.051e-194	638.0	COG1629@1|root,COG1629@2|Bacteria,3Y2JN@57723|Acidobacteria,2JI08@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_3719539_2	234267.Acid_1337	4.562e-40	161.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase
HFD2_k127_3719539_1	1340493.JNIF01000003_gene2526	6.054e-87	300.0	COG1215@1|root,COG1215@2|Bacteria,3Y2JE@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase, family 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HFD2_k127_3719539_3	1267535.KB906767_gene3425	2.309e-28	122.0	COG2510@1|root,COG2510@2|Bacteria,3Y9G6@57723|Acidobacteria,2JNNR@204432|Acidobacteriia	204432|Acidobacteriia	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3719539_4	234267.Acid_6448	2.923e-26	109.0	COG2510@1|root,COG2510@2|Bacteria,3Y4SP@57723|Acidobacteria	57723|Acidobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3734005_0	251221.35211983	1.065e-171	567.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3734005_2	1267535.KB906767_gene1551	1.888e-101	346.0	COG0179@1|root,COG0179@2|Bacteria,3Y4QZ@57723|Acidobacteria,2JP1G@204432|Acidobacteriia	204432|Acidobacteriia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_3734005_1	234267.Acid_6430	2.105e-166	533.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria	57723|Acidobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD2_k127_3742123_0	234267.Acid_5526	4.011e-228	713.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HFD2_k127_3742123_1	204669.Acid345_3142	8.618e-182	571.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria,2JHXX@204432|Acidobacteriia	204432|Acidobacteriia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_3748636_0	234267.Acid_4431	2.385e-95	326.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_3748636_1	555793.WSK_4047	2.947e-17	84.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_375987_2	1340493.JNIF01000003_gene3726	1.956e-73	254.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria	57723|Acidobacteria	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_375987_0	234267.Acid_7311	4.034e-122	401.0	COG0707@1|root,COG0707@2|Bacteria,3Y48B@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD2_k127_375987_1	234267.Acid_7310	2.74e-110	360.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_3765305_6	743718.Isova_0908	6.1e-12	68.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4F3WR@85017|Promicromonosporaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD2_k127_3765305_3	234267.Acid_2537	1.463e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,3Y5RY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3765305_1	1267535.KB906767_gene5362	8.978e-28	119.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_3765305_4	1245475.ANAE01000110_gene3164	2.031e-15	81.0	COG1167@1|root,COG1167@2|Bacteria,2GJ5P@201174|Actinobacteria,4EGIU@85012|Streptosporangiales	201174|Actinobacteria	K	Aminotransferase class I and II	pdxR	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HFD2_k127_3765305_5	568703.LGG_02334	1.044e-12	79.0	COG4194@1|root,COG4194@2|Bacteria,1UY2R@1239|Firmicutes,4HEEQ@91061|Bacilli,3F7N8@33958|Lactobacillaceae	91061|Bacilli	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
HFD2_k127_3765305_0	1278073.MYSTI_04966	2.998e-46	179.0	COG3315@1|root,COG3315@2|Bacteria,1REBR@1224|Proteobacteria,42W2V@68525|delta/epsilon subdivisions,2WRPW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HFD2_k127_3765305_2	671143.DAMO_2848	1.821e-26	108.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2NNX4@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
HFD2_k127_3790844_6	1196083.SALWKB12_0795	1.036e-06	51.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,2KRC6@206351|Neisseriales	206351|Neisseriales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HFD2_k127_3790844_0	234267.Acid_3254	2.565e-135	438.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_3790844_5	234267.Acid_4213	3.75e-24	102.0	2DG6A@1|root,2ZUQ0@2|Bacteria,3Y8Y2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3790844_3	234267.Acid_4214	6.634e-53	190.0	2B6R1@1|root,31ZPU@2|Bacteria,3Y4VP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3790844_2	234267.Acid_7047	1.604e-118	396.0	2F7Z0@1|root,340CS@2|Bacteria,3Y88S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3790844_4	1267535.KB906767_gene954	1.794e-44	173.0	2BKZZ@1|root,32FGS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HFD2_k127_3790844_1	179408.Osc7112_5083	6.838e-121	390.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HFD2_k127_3825037_3	234267.Acid_3964	1.09e-54	216.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y7IX@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HAMP,Pkinase
HFD2_k127_3825037_4	1267535.KB906767_gene4499	4.668e-52	191.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia	204432|Acidobacteriia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD2_k127_3825037_0	1267535.KB906767_gene2457	1.476e-117	385.0	2F5SA@1|root,33YB5@2|Bacteria,3Y7SK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3825037_1	471854.Dfer_0258	9.302e-63	233.0	COG1228@1|root,COG1228@2|Bacteria,4NGGD@976|Bacteroidetes,47R4K@768503|Cytophagia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,SnoaL_2
HFD2_k127_3825037_2	234267.Acid_2377	6.677e-56	199.0	COG0388@1|root,COG0388@2|Bacteria,3Y7FJ@57723|Acidobacteria	57723|Acidobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_3825037_5	234267.Acid_2377	1.065e-17	90.0	COG0388@1|root,COG0388@2|Bacteria,3Y7FJ@57723|Acidobacteria	57723|Acidobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_3837221_4	1267535.KB906767_gene3533	3.387e-54	194.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HFD2_k127_3837221_0	1267535.KB906767_gene589	4.022e-161	520.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria,2JHNE@204432|Acidobacteriia	2|Bacteria	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD2_k127_3837221_1	1267535.KB906767_gene588	3.997e-142	457.0	COG1181@1|root,COG1181@2|Bacteria,3Y3HW@57723|Acidobacteria,2JI4N@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD2_k127_3837221_2	1267535.KB906767_gene5022	1.342e-129	422.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_3837221_6	880073.Calab_3410	5.435e-19	88.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_3837221_5	944481.JAFP01000001_gene95	9.406e-24	106.0	COG1598@1|root,COG1598@2|Bacteria,1QSXW@1224|Proteobacteria,42X4E@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_3837221_3	1267535.KB906767_gene5021	1.239e-67	231.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria,2JI7K@204432|Acidobacteriia	204432|Acidobacteriia	J	class II (D K	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_3880265_8	1499967.BAYZ01000181_gene4491	2.319e-14	81.0	2E6BY@1|root,31ESQ@2|Bacteria,2NS0H@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3880265_4	1239962.C943_03679	2.424e-55	208.0	COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,47JYZ@768503|Cytophagia	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HFD2_k127_3880265_3	234267.Acid_4240	4.333e-60	218.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_3880265_5	234267.Acid_5179	9.15e-50	182.0	COG0779@1|root,COG0779@2|Bacteria,3Y528@57723|Acidobacteria	57723|Acidobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD2_k127_3880265_1	234267.Acid_5180	4.279e-201	636.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria	57723|Acidobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HFD2_k127_3880265_0	234267.Acid_5181	3.305e-321	1009.0	COG0532@1|root,COG3266@1|root,COG0532@2|Bacteria,COG3266@2|Bacteria,3Y3UG@57723|Acidobacteria	57723|Acidobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
HFD2_k127_3880265_7	1267535.KB906767_gene3291	6.98e-31	124.0	COG1550@1|root,COG1550@2|Bacteria,3Y5B8@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HFD2_k127_3880265_6	1267534.KB906754_gene2695	6.119e-33	138.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HFD2_k127_3882277_2	234267.Acid_4427	4.859e-228	728.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria	57723|Acidobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD2_k127_3882277_3	234267.Acid_7572	3.356e-208	676.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_3882277_0	234267.Acid_7146	7.58e-262	819.0	COG1916@1|root,COG1916@2|Bacteria,3Y6KT@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3882277_6	234267.Acid_7147	1.343e-137	445.0	COG0714@1|root,COG0714@2|Bacteria,3Y6Z3@57723|Acidobacteria	57723|Acidobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HFD2_k127_3882277_12	706587.Desti_0629	1.012e-15	79.0	COG5450@1|root,COG5450@2|Bacteria,1Q2TR@1224|Proteobacteria,42W8I@68525|delta/epsilon subdivisions,2WRTI@28221|Deltaproteobacteria,2MS5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HFD2_k127_3882277_9	316067.Geob_3270	3.712e-33	134.0	COG1487@1|root,COG1487@2|Bacteria,1MZZ9@1224|Proteobacteria,42UZN@68525|delta/epsilon subdivisions,2WQ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_3882277_11	309801.trd_A0237	1.549e-21	101.0	COG4636@1|root,COG4636@2|Bacteria,2G90F@200795|Chloroflexi	200795|Chloroflexi	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_3882277_8	234267.Acid_6760	2.97e-53	193.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HFD2_k127_3882277_10	234267.Acid_6759	7.166e-26	107.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HFD2_k127_3882277_5	1340493.JNIF01000004_gene721	1.317e-145	468.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD2_k127_3882277_4	1267535.KB906767_gene697	1.091e-207	662.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HFD2_k127_3882277_1	1267535.KB906767_gene1569	1.832e-232	740.0	COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria	57723|Acidobacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
HFD2_k127_3882277_7	1379270.AUXF01000001_gene2134	4.691e-100	334.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	oxlT	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HFD2_k127_3889723_1	195250.CM001776_gene1111	1.108e-46	177.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_3889723_3	1108045.GORHZ_066_00020	2.399e-17	87.0	2C62F@1|root,335K1@2|Bacteria,2GS5K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3889723_0	1108045.GORHZ_109_00020	1.145e-91	318.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HFD2_k127_3889723_2	234267.Acid_0409	2.229e-28	114.0	COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD2_k127_3941681_9	481448.Minf_2223	1.598e-12	69.0	COG2010@1|root,COG2010@2|Bacteria,46WD1@74201|Verrucomicrobia,37GQ1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_3941681_11	1156937.MFUM_940020	6.694e-09	62.0	28T88@1|root,2ZFGX@2|Bacteria,46Z1A@74201|Verrucomicrobia,37H1B@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3941681_4	234267.Acid_0556	3.979e-82	280.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	rfbB	-	3.6.3.38,3.6.3.40	ko:K01990,ko:K09689,ko:K09691,ko:K09693	ko02010,map02010	M00249,M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
HFD2_k127_3941681_8	247633.GP2143_18131	1.083e-24	109.0	2C42J@1|root,3359Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3941681_7	136993.KB900627_gene392	3.342e-31	134.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3941681_5	760192.Halhy_5129	3.589e-77	276.0	COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1IQD7@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_3941681_3	1122179.KB890458_gene744	6.364e-92	319.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1IPY5@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_3941681_10	234267.Acid_2313	9.67e-11	65.0	2EVWN@1|root,33PAB@2|Bacteria,3Y5UR@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3941681_1	234267.Acid_2756	3.066e-120	399.0	COG2755@1|root,COG2755@2|Bacteria,3Y2KK@57723|Acidobacteria	2|Bacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_3941681_6	402881.Plav_0614	9.059e-74	261.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,1JQ7T@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HFD2_k127_3941681_0	357808.RoseRS_3858	6.654e-270	874.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HFD2_k127_3941681_2	1090318.ATTI01000001_gene966	1.775e-117	385.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,2K02B@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	MFS_1
HFD2_k127_3947588_2	1267534.KB906754_gene3349	1.715e-86	295.0	COG2329@1|root,COG5485@1|root,COG2329@2|Bacteria,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HFD2_k127_3947588_1	234267.Acid_5943	7.318e-110	358.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria	57723|Acidobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD2_k127_3947588_0	1267535.KB906767_gene3786	0.0	1092.0	COG0046@1|root,COG0046@2|Bacteria,3Y30N@57723|Acidobacteria,2JHYK@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_3947588_3	1267535.KB906767_gene3785	2.84e-75	256.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HFD2_k127_3963772_11	1120953.AUBH01000005_gene2232	1.662e-21	106.0	COG3595@1|root,COG3595@2|Bacteria,1RFCY@1224|Proteobacteria,1S5RB@1236|Gammaproteobacteria,467PX@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_3963772_7	1340493.JNIF01000003_gene2123	3.227e-58	211.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3963772_3	1340493.JNIF01000003_gene2401	2.174e-146	478.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_3963772_6	234267.Acid_7083	7.947e-69	241.0	COG1778@1|root,COG1778@2|Bacteria,3Y5BY@57723|Acidobacteria	57723|Acidobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HFD2_k127_3963772_5	861299.J421_0663	5.882e-89	306.0	COG1707@1|root,COG1707@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
HFD2_k127_3963772_2	1267535.KB906767_gene4947	1.257e-159	517.0	COG0076@1|root,COG0076@2|Bacteria,3Y2SW@57723|Acidobacteria,2JMFG@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD2_k127_3963772_1	1340493.JNIF01000003_gene2949	1.856e-178	578.0	COG0642@1|root,COG0642@2|Bacteria,3Y9DC@57723|Acidobacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,Response_reg
HFD2_k127_3963772_4	240015.ACP_2970	1.522e-101	341.0	COG0167@1|root,COG0167@2|Bacteria,3Y2K1@57723|Acidobacteria,2JHXE@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD2_k127_3963772_8	1340493.JNIF01000003_gene2947	4.104e-44	163.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_3963772_0	234267.Acid_5497	1.386e-182	584.0	COG0557@1|root,COG0557@2|Bacteria,3Y2QV@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HFD2_k127_3963772_10	1340493.JNIF01000003_gene2169	7.405e-28	114.0	COG3349@1|root,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_3980664_3	1121346.KB899824_gene3074	1.423e-32	143.0	28NCT@1|root,2ZBFR@2|Bacteria,1UKIC@1239|Firmicutes,4HF21@91061|Bacilli,26R8W@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3980664_1	204669.Acid345_0452	1.223e-164	530.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	204432|Acidobacteriia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD2_k127_3980664_0	234267.Acid_4123	1.312e-169	541.0	COG3307@1|root,COG3307@2|Bacteria,3Y67G@57723|Acidobacteria	57723|Acidobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD2_k127_3980664_4	573370.DMR_08990	1.849e-22	107.0	COG4122@1|root,COG4122@2|Bacteria,1N2AR@1224|Proteobacteria,439ZI@68525|delta/epsilon subdivisions,2X2GU@28221|Deltaproteobacteria,2MDMY@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HFD2_k127_3980664_2	216591.BCAL1340	3.263e-109	357.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VM53@28216|Betaproteobacteria,1K0IU@119060|Burkholderiaceae	28216|Betaproteobacteria	C	maleylacetate reductase	-	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HFD2_k127_3987686_0	1380394.JADL01000004_gene5869	2.789e-55	196.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,2JUDH@204441|Rhodospirillales	204441|Rhodospirillales	L	Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD2_k127_3987686_1	136993.KB900627_gene392	3.875e-32	135.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3987686_4	1266914.ATUK01000010_gene1443	7.786e-17	89.0	COG3193@1|root,COG3193@2|Bacteria,1RJ3X@1224|Proteobacteria,1S8FV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_3987686_2	1007104.SUS17_2415	1.211e-27	123.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2U8EJ@28211|Alphaproteobacteria,2KCBM@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3987686_3	555793.WSK_3236	1.3e-21	101.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3987686_5	402777.KB235904_gene2790	1.225e-06	60.0	COG5305@1|root,COG5305@2|Bacteria,1G0MG@1117|Cyanobacteria,1H7N3@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_4001636_15	1340493.JNIF01000003_gene3955	4.699e-40	154.0	COG2322@1|root,COG2322@2|Bacteria,3Y5H4@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HFD2_k127_4001636_14	1267535.KB906767_gene1278	3.82e-41	160.0	COG1999@1|root,COG1999@2|Bacteria,3Y855@57723|Acidobacteria	57723|Acidobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD2_k127_4001636_7	234267.Acid_4382	2.728e-107	354.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria	57723|Acidobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HFD2_k127_4001636_11	234267.Acid_4383	5.399e-47	181.0	COG1612@1|root,COG1612@2|Bacteria	2|Bacteria	O	heme a metabolic process	ctaA	-	-	ko:K02259,ko:K03110	ko00190,ko00860,ko01100,ko01110,ko02020,ko02024,ko03060,ko03070,ko04714,map00190,map00860,map01100,map01110,map02020,map02024,map03060,map03070,map04714	M00154,M00335	R07412	RC00769	ko00000,ko00001,ko00002,ko02044,ko03029	3.A.5.1,3.A.5.2,3.A.5.7,3.D.4.4	-	-	COX15-CtaA
HFD2_k127_4001636_6	483219.LILAB_12345	2.532e-111	371.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_4001636_9	234267.Acid_5486	4.794e-101	339.0	COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria	2|Bacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4001636_19	1235279.C772_00198	4.804e-11	68.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,4HIXH@91061|Bacilli,26FDA@186818|Planococcaceae	91061|Bacilli	T	cheY-homologous receiver domain	spo0F	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD2_k127_4001636_13	234267.Acid_1016	3.78e-41	156.0	2DNWY@1|root,32UJU@2|Bacteria,3Y584@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2393)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2393
HFD2_k127_4001636_2	234267.Acid_1017	7.46e-181	577.0	COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_4001636_1	234267.Acid_1018	7.882e-233	728.0	COG0312@1|root,COG0312@2|Bacteria,3Y2TY@57723|Acidobacteria	57723|Acidobacteria	H	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	CoaE,PmbA_TldD
HFD2_k127_4001636_16	1267535.KB906767_gene1514	1.261e-22	104.0	COG2318@1|root,COG2318@2|Bacteria,3Y8J8@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4001636_5	1340493.JNIF01000004_gene660	1.049e-123	414.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50,2.7.11.1	ko:K12132,ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000,ko01001	-	-	-	DinB_2,FGE-sulfatase
HFD2_k127_4001636_10	234267.Acid_5266	7.127e-73	248.0	COG1839@1|root,COG1839@2|Bacteria,3Y7IR@57723|Acidobacteria	57723|Acidobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HFD2_k127_4001636_0	234267.Acid_5242	1.05e-320	996.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria	57723|Acidobacteria	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD2_k127_4001636_18	655815.ZPR_1397	1.725e-14	80.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1I28C@117743|Flavobacteriia	976|Bacteroidetes	J	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4001636_8	1267535.KB906767_gene1564	7.111e-102	339.0	COG1560@1|root,COG1560@2|Bacteria,3Y2RW@57723|Acidobacteria,2JIMS@204432|Acidobacteriia	204432|Acidobacteriia	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD2_k127_4001636_3	1267535.KB906767_gene1561	3.082e-172	548.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria,2JHKV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD2_k127_4001636_4	234267.Acid_0600	9.071e-129	421.0	COG1104@1|root,COG1104@2|Bacteria,3Y389@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_4001636_12	1267535.KB906767_gene5111	1.16e-41	154.0	COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria,2JINJ@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_4064114_3	234267.Acid_1306	4.774e-59	229.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_4064114_0	1340493.JNIF01000004_gene24	9.397e-300	937.0	COG1529@1|root,COG1529@2|Bacteria,3Y77V@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_4064114_1	234267.Acid_2557	1.325e-281	881.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_4064114_6	247633.GP2143_17801	6.402e-36	142.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4064114_5	247633.GP2143_17796	3.116e-44	174.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4064114_2	344747.PM8797T_08574	1.335e-111	378.0	COG4225@1|root,COG4225@2|Bacteria,2IZFK@203682|Planctomycetes	203682|Planctomycetes	S	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
HFD2_k127_4064114_7	876269.ARWA01000001_gene3105	1.803e-14	78.0	COG1359@1|root,COG1359@2|Bacteria,1PS55@1224|Proteobacteria,2V4C6@28211|Alphaproteobacteria,3NCI7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD2_k127_4064114_4	1267535.KB906767_gene5300	8.455e-51	182.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_4078120_3	234267.Acid_4681	5.979e-70	238.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_4078120_9	199310.c3276	5.141e-12	77.0	2EE8J@1|root,33831@2|Bacteria,1ND96@1224|Proteobacteria,1SED2@1236|Gammaproteobacteria,3XQIT@561|Escherichia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_6	627192.SLG_25140	1.912e-29	129.0	2EVK9@1|root,33P0C@2|Bacteria,1NDYB@1224|Proteobacteria,2UQHZ@28211|Alphaproteobacteria,2K9N4@204457|Sphingomonadales	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_4	136993.KB900627_gene392	3.271e-33	138.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_7	1267535.KB906767_gene4319	4.954e-28	122.0	COG2076@1|root,COG2076@2|Bacteria,3Y8G8@57723|Acidobacteria	57723|Acidobacteria	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_8	234267.Acid_4551	6.465e-27	115.0	COG2076@1|root,COG2076@2|Bacteria,3Y93B@57723|Acidobacteria	57723|Acidobacteria	P	Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_0	671143.DAMO_0621	0.0	1245.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HFD2_k127_4078120_5	1267535.KB906767_gene2328	7.836e-31	125.0	COG0792@1|root,COG0792@2|Bacteria,3Y56J@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HFD2_k127_4078120_1	234267.Acid_2434	3.467e-91	301.0	COG0500@1|root,COG2226@2|Bacteria,3Y752@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4078120_2	234267.Acid_6753	9.536e-76	262.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria,3Y4DW@57723|Acidobacteria	2|Bacteria	T	Histidine kinase-like ATPase domain	rsbW	-	2.7.11.1,3.4.21.53	ko:K01338,ko:K04757,ko:K06379,ko:K08282,ko:K17752	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko03021	-	-	-	HATPase_c_2,HTH_8,Response_reg
HFD2_k127_4087504_0	1267535.KB906767_gene605	2.404e-245	764.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD2_k127_4087504_6	401053.AciPR4_3113	1.239e-124	407.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria,2JHPX@204432|Acidobacteriia	57723|Acidobacteria	O	SMART band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_4087504_20	234267.Acid_1594	5.685e-48	175.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD2_k127_4087504_10	234267.Acid_3676	1.795e-90	300.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria	57723|Acidobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD2_k127_4087504_3	234267.Acid_5354	9.313e-164	523.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,3Y49J@57723|Acidobacteria	57723|Acidobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
HFD2_k127_4087504_18	234267.Acid_1158	1.526e-56	203.0	2E71G@1|root,331K5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_8	234267.Acid_0347	1.503e-112	374.0	COG4974@1|root,COG4974@2|Bacteria,3Y2VX@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_4087504_2	1267535.KB906767_gene4427	4.214e-187	595.0	COG1206@1|root,COG1206@2|Bacteria,3Y2KD@57723|Acidobacteria,2JIGU@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HFD2_k127_4087504_1	234267.Acid_7412	1.344e-233	734.0	COG1884@1|root,COG1884@2|Bacteria,3Y2QA@57723|Acidobacteria	57723|Acidobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_4087504_25	234267.Acid_7411	2.536e-13	78.0	28WCX@1|root,2ZID8@2|Bacteria,3Y8ZH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_24	1267535.KB906767_gene2581	4.195e-32	129.0	2EE2F@1|root,337X5@2|Bacteria,3Y5GQ@57723|Acidobacteria,2JJT5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_26	56107.Cylst_1514	3.29e-09	69.0	COG2366@1|root,COG2366@2|Bacteria,1G0QT@1117|Cyanobacteria,1HPFW@1161|Nostocales	1117|Cyanobacteria	S	PFAM Peptidase S45, penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD2_k127_4087504_4	234267.Acid_2703	1.464e-139	459.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_12	1340493.JNIF01000003_gene2370	6.542e-83	286.0	COG3597@1|root,COG3597@2|Bacteria,3Y7Z9@57723|Acidobacteria	57723|Acidobacteria	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_5	1340493.JNIF01000003_gene1340	1.413e-131	432.0	COG0277@1|root,COG0277@2|Bacteria,3Y766@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_4087504_14	1267535.KB906767_gene3788	9.881e-63	218.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria,2JJ1A@204432|Acidobacteriia	204432|Acidobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD2_k127_4087504_9	1267535.KB906767_gene3789	2.475e-96	318.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_4087504_7	1038860.AXAP01000021_gene5519	2.541e-124	411.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,3JVUB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD2_k127_4087504_21	247633.GP2143_17796	5.522e-39	158.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_13	247633.GP2143_17791	4.734e-82	282.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_27	402881.Plav_1692	0.0008801	51.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,1JN3F@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Peptidase family M48	MA20_40030	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
HFD2_k127_4087504_17	247633.GP2143_18126	1.094e-58	217.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_22	247633.GP2143_17801	9.906e-37	143.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_16	247633.GP2143_17796	4.963e-61	223.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_15	247633.GP2143_18126	1.508e-62	228.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_23	247633.GP2143_17801	9.778e-35	138.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_19	247633.GP2143_17796	1.783e-56	209.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4087504_11	450851.PHZ_c2572	1.99e-83	285.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103325_29	1408224.SAMCCGM7_c6070	1.318e-11	67.0	COG4319@1|root,COG4319@2|Bacteria,1NH3X@1224|Proteobacteria,2VGUW@28211|Alphaproteobacteria,4BNMY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_4103325_23	517418.Ctha_0741	1.047e-26	115.0	COG2010@1|root,COG2010@2|Bacteria,1FEAI@1090|Chlorobi	1090|Chlorobi	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HFD2_k127_4103325_18	926560.KE387023_gene2407	1.081e-51	187.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD2_k127_4103325_21	290397.Adeh_2888	3.154e-38	152.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4103325_3	234267.Acid_5197	3.82e-178	564.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_6,HTH_18
HFD2_k127_4103325_5	234267.Acid_5196	9.37e-135	434.0	COG0500@1|root,COG2226@2|Bacteria,3Y4B3@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_4103325_0	266117.Rxyl_0336	6.515e-241	750.0	COG3391@1|root,COG3391@2|Bacteria,2I9U0@201174|Actinobacteria,4CSKA@84995|Rubrobacteria	84995|Rubrobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
HFD2_k127_4103325_14	1267533.KB906738_gene2316	2.483e-64	226.0	2AI77@1|root,318MJ@2|Bacteria,3Y7RV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103325_19	1267535.KB906767_gene5334	3.277e-51	183.0	COG1188@1|root,COG1188@2|Bacteria,3Y5C6@57723|Acidobacteria,2JJNN@204432|Acidobacteriia	204432|Acidobacteriia	J	RNA-binding S4 domain protein	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HFD2_k127_4103325_12	1170562.Cal6303_5676	4.297e-73	267.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_4103325_17	1120983.KB894576_gene3342	6.485e-56	205.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,1JNTP@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_4103325_25	1340493.JNIF01000003_gene2122	8.691e-26	114.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103325_22	136993.KB900627_gene392	1.331e-33	143.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103325_11	234267.Acid_1378	1.596e-84	300.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HFD2_k127_4103325_1	452637.Oter_2460	7.657e-209	669.0	COG0651@1|root,COG0651@2|Bacteria,46U4G@74201|Verrucomicrobia,3K7M3@414999|Opitutae	74201|Verrucomicrobia	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HFD2_k127_4103325_8	452637.Oter_2461	1.294e-108	362.0	COG0650@1|root,COG0650@2|Bacteria,46V7E@74201|Verrucomicrobia,3K7BZ@414999|Opitutae	74201|Verrucomicrobia	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HFD2_k127_4103325_15	452637.Oter_2462	1.35e-60	216.0	COG4237@1|root,COG4237@2|Bacteria,46W3G@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD2_k127_4103325_6	452637.Oter_2463	1.38e-117	399.0	COG0651@1|root,COG0651@2|Bacteria,46UK3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HFD2_k127_4103325_2	452637.Oter_2464	3.413e-188	602.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,46TQW@74201|Verrucomicrobia,3K7GA@414999|Opitutae	74201|Verrucomicrobia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
HFD2_k127_4103325_10	452637.Oter_2465	1.239e-95	323.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,46VST@74201|Verrucomicrobia,3K7DE@414999|Opitutae	74201|Verrucomicrobia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HFD2_k127_4103325_20	234267.Acid_7227	2.712e-41	164.0	COG0640@1|root,COG0640@2|Bacteria,3Y5UV@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_4103325_24	639030.JHVA01000001_gene2810	5.843e-26	126.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,GerE,Trans_reg_C
HFD2_k127_4103325_7	861299.J421_2157	1.544e-112	400.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
HFD2_k127_4103325_26	157783.LK03_21270	2.599e-16	91.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,1SCJZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
HFD2_k127_4103325_9	41431.PCC8801_0005	1.583e-98	327.0	COG2020@1|root,COG2020@2|Bacteria,1G4HN@1117|Cyanobacteria,3KGIV@43988|Cyanothece	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HFD2_k127_4103325_4	234267.Acid_3186	2.285e-146	473.0	COG0306@1|root,COG0306@2|Bacteria,3Y3ZW@57723|Acidobacteria	57723|Acidobacteria	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD2_k127_4103325_13	234267.Acid_3187	4.733e-72	248.0	COG1392@1|root,COG1392@2|Bacteria,3Y58U@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD2_k127_4103325_27	234267.Acid_1113	3.793e-16	83.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD2_k127_4103325_28	1267535.KB906767_gene4165	3.028e-15	81.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria,2JIPK@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_4115935_1	234267.Acid_1559	1.137e-141	465.0	COG0498@1|root,COG0498@2|Bacteria,3Y3G4@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_4115935_2	1267535.KB906767_gene5203	2.247e-137	443.0	COG1063@1|root,COG1063@2|Bacteria,3Y7C5@57723|Acidobacteria	57723|Acidobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD2_k127_4115935_4	234267.Acid_5172	1.284e-73	256.0	COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria	57723|Acidobacteria	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD2_k127_4115935_6	1267535.KB906767_gene2285	2.735e-53	189.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria,2JIGQ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4115935_5	1340493.JNIF01000003_gene4516	6.2e-58	203.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4115935_3	1267535.KB906767_gene2284	6.878e-93	315.0	COG1994@1|root,COG1994@2|Bacteria,3Y4IT@57723|Acidobacteria,2JMSE@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4115935_7	1267535.KB906767_gene2283	6.579e-46	166.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria,2JP27@204432|Acidobacteriia	204432|Acidobacteriia	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_4115935_8	316057.RPD_3977	5.568e-23	108.0	COG2105@1|root,COG2105@2|Bacteria,1N80E@1224|Proteobacteria,2U5YU@28211|Alphaproteobacteria,3JY9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
HFD2_k127_4115935_0	1267535.KB906767_gene480	1.166e-155	496.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_4162445_0	935840.JAEQ01000001_gene3216	4.519e-70	246.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43H8P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Pyrrolo-quinoline quinone	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_4162445_4	1395516.PMO01_10150	4.055e-08	62.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,1S67S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4162445_2	1340493.JNIF01000003_gene1551	2.12e-36	143.0	COG2318@1|root,COG2318@2|Bacteria,3Y503@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4162445_5	1183377.Py04_1670	0.0002602	51.0	COG0546@1|root,arCOG02292@2157|Archaea,2XYWB@28890|Euryarchaeota,245G3@183968|Thermococci	183968|Thermococci	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_4162445_1	1128421.JAGA01000002_gene261	5.461e-49	189.0	COG1319@1|root,COG1319@2|Bacteria,2NQUQ@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_4162445_3	1051632.TPY_2012	3.032e-27	122.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD2_k127_4186391_1	234267.Acid_0083	7.461e-101	342.0	COG1502@1|root,COG1502@2|Bacteria,3Y5UA@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD2_k127_4186391_4	234267.Acid_0082	4.135e-22	103.0	2FE51@1|root,3464Y@2|Bacteria,3Y8E0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4186391_2	1267534.KB906759_gene1707	3.217e-97	329.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_4186391_3	864051.BurJ1DRAFT_1919	3.016e-25	117.0	COG4922@1|root,COG4922@2|Bacteria,1MYTU@1224|Proteobacteria,2WG68@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4186391_5	627192.SLG_27840	1.113e-12	79.0	COG4922@1|root,COG4922@2|Bacteria,1MYTU@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_4186391_0	1128421.JAGA01000002_gene1496	3.879e-151	489.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
HFD2_k127_4187570_22	247633.GP2143_18121	6.262e-30	136.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_23	247633.GP2143_18126	4.062e-29	130.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_19	316058.RPB_0922	8.874e-33	138.0	2E9TF@1|root,333ZG@2|Bacteria,1NQ16@1224|Proteobacteria,2UR81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	MUG113
HFD2_k127_4187570_26	671143.DAMO_0603	2.993e-20	91.0	2C2YU@1|root,33M8J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_25	926566.Terro_4177	1.12e-23	108.0	29ZWG@1|root,30MXU@2|Bacteria,3Y5VK@57723|Acidobacteria,2JMXT@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4187570_8	107636.JQNK01000009_gene1854	4.4e-112	374.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4187570_1	936455.KI421499_gene1398	1.122e-231	722.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,3JUB5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD2_k127_4187570_18	1267533.KB906736_gene1100	1.28e-38	146.0	29WUP@1|root,30IG4@2|Bacteria,3Y82K@57723|Acidobacteria	57723|Acidobacteria	S	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_0	234267.Acid_7271	2.973e-239	762.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD2_k127_4187570_7	234267.Acid_3643	5.521e-121	407.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	LpoB,Sel1
HFD2_k127_4187570_21	1340493.JNIF01000004_gene775	2.979e-30	139.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HFD2_k127_4187570_13	1340493.JNIF01000003_gene3120	4.081e-63	244.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HFD2_k127_4187570_20	1189612.A33Q_3042	1.219e-31	136.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,LRR_5
HFD2_k127_4187570_5	713586.KB900536_gene94	1.442e-140	464.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_4187570_16	246969.TAM4_2433	1.706e-42	166.0	COG0463@1|root,arCOG01381@2157|Archaea,2XVM0@28890|Euryarchaeota,243JM@183968|Thermococci	183968|Thermococci	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4187570_12	1340493.JNIF01000003_gene4768	1.129e-63	230.0	2941A@1|root,2ZRG3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_15	1340493.JNIF01000003_gene4767	2.705e-53	200.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_4187570_10	91464.S7335_1514	3.766e-87	297.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H3HJ@1129|Synechococcus	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HFD2_k127_4187570_11	1173028.ANKO01000030_gene3281	1.327e-82	295.0	COG3379@1|root,COG3379@2|Bacteria,1G44K@1117|Cyanobacteria,1HD9A@1150|Oscillatoriales	1117|Cyanobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_4187570_9	272123.Anacy_3671	3.651e-103	348.0	COG0438@1|root,COG0438@2|Bacteria,1GIW1@1117|Cyanobacteria,1HK5Q@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_4187570_2	886293.Sinac_5556	9.377e-179	577.0	COG1232@1|root,COG1232@2|Bacteria,2IYF5@203682|Planctomycetes	203682|Planctomycetes	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_4187570_3	448385.sce1158	1.866e-160	521.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,437VX@68525|delta/epsilon subdivisions,2X35F@28221|Deltaproteobacteria,2YUCR@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_4187570_6	234267.Acid_5622	5.483e-134	441.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,FlgD_ig,NHL
HFD2_k127_4187570_4	234267.Acid_5621	2.039e-141	457.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,FlgD_ig,NHL
HFD2_k127_4187570_27	1090318.ATTI01000001_gene970	8.559e-18	96.0	COG3258@1|root,COG3258@2|Bacteria,1R0F2@1224|Proteobacteria,2TYQH@28211|Alphaproteobacteria,2K6ZI@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_4187570_28	1101195.Meth11DRAFT_1464	4.498e-08	60.0	2BUQD@1|root,32Q1F@2|Bacteria,1PJPP@1224|Proteobacteria,2W83R@28216|Betaproteobacteria,2KNSW@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_30	627192.SLG_09880	1.033e-07	63.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2VG0A@28211|Alphaproteobacteria,2KBBC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_14	1279017.AQYJ01000028_gene2525	1.667e-58	215.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4187570_29	715451.ambt_12010	6.124e-08	64.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4187570_17	2002.JOEQ01000028_gene8082	3.581e-40	154.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4EI3W@85012|Streptosporangiales	201174|Actinobacteria	S	Epoxide hydrolase N terminus	-	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
HFD2_k127_419271_0	234267.Acid_1438	2.615e-58	213.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_419271_1	1267535.KB906767_gene457	2.188e-31	136.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4194035_5	1183438.GKIL_4354	2.711e-81	284.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_4194035_7	234267.Acid_4013	3.56e-45	183.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4194035_3	633149.Bresu_2027	4.854e-107	368.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria,2KI78@204458|Caulobacterales	204458|Caulobacterales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4194035_0	626887.J057_06051	1.878e-216	692.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,464P3@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD2_k127_4194035_1	768066.HELO_3953	1.653e-206	664.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,1RS0H@1236|Gammaproteobacteria,1XIV9@135619|Oceanospirillales	135619|Oceanospirillales	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
HFD2_k127_4194035_2	1121033.AUCF01000016_gene5484	1.579e-115	377.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria,2JU12@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_4194035_6	118163.Ple7327_1778	4.706e-63	226.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,3VJ5H@52604|Pleurocapsales	1117|Cyanobacteria	S	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD2_k127_4194035_4	331869.BAL199_03229	3.038e-87	293.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4BRM5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	pcaF	-	2.3.1.16,2.3.1.174,2.3.1.9	ko:K00626,ko:K00632,ko:K07823	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_4232847_16	1267535.KB906767_gene680	1.861e-16	84.0	COG1983@1|root,COG1983@2|Bacteria,3Y5HA@57723|Acidobacteria	57723|Acidobacteria	KT	Phage shock protein C, PspC	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC,zinc_ribbon_2
HFD2_k127_4232847_0	543728.Vapar_0124	2.19e-208	661.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2VIK2@28216|Betaproteobacteria,4ACVQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_4232847_5	1340493.JNIF01000003_gene2640	5.408e-97	330.0	COG1028@1|root,COG1028@2|Bacteria,3Y6TA@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_4232847_3	1267535.KB906767_gene2154	9.835e-126	409.0	COG1131@1|root,COG1131@2|Bacteria,3Y4CW@57723|Acidobacteria,2JMQR@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_4232847_2	234267.Acid_0080	3.967e-153	504.0	COG0842@1|root,COG1228@1|root,COG0842@2|Bacteria,COG1228@2|Bacteria,3Y750@57723|Acidobacteria	57723|Acidobacteria	QV	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,Amidohydro_1
HFD2_k127_4232847_18	469383.Cwoe_2923	1.758e-10	66.0	2A5VU@1|root,30UMP@2|Bacteria,2HRRK@201174|Actinobacteria,4CTU7@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_10	880073.Calab_1106	1.648e-44	186.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2,TAT_signal
HFD2_k127_4232847_4	1267535.KB906767_gene4796	5.319e-102	366.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria,2JIZI@204432|Acidobacteriia	204432|Acidobacteriia	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_4232847_7	880073.Calab_1108	7.141e-75	265.0	COG1319@1|root,COG1319@2|Bacteria,2NQUQ@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_4232847_1	1265313.HRUBRA_01849	6.544e-187	606.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ_2
HFD2_k127_4232847_13	1268072.PSAB_07645	9.409e-32	137.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4232847_14	136993.KB900627_gene392	1.153e-29	130.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_11	136993.KB900627_gene391	6.853e-34	134.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria,2UJHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_12	136993.KB900627_gene393	3.981e-32	137.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_6	136993.KB900627_gene392	6.863e-86	291.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_17	1267534.KB906756_gene595	2.683e-13	76.0	COG0662@1|root,COG0662@2|Bacteria,3Y8MJ@57723|Acidobacteria,2JNFX@204432|Acidobacteriia	204432|Acidobacteriia	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4232847_15	234267.Acid_0557	5.013e-17	81.0	2DVVI@1|root,33XD7@2|Bacteria	234267.Acid_0557|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4247018_2	234267.Acid_6884	1.093e-07	63.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HFD2_k127_4247018_0	1267535.KB906767_gene791	9.037e-97	324.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HFD2_k127_4253462_0	359.CN09_32710	3.517e-59	218.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,4BBTJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HFD2_k127_4321807_4	1267535.KB906767_gene1044	2.816e-64	223.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria	57723|Acidobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD2_k127_4321807_3	234267.Acid_0794	2.565e-82	286.0	COG0392@1|root,COG0392@2|Bacteria,3Y3SG@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD2_k127_4321807_2	1267535.KB906767_gene1043	5.505e-90	302.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4321807_6	234267.Acid_0792	5.346e-50	184.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_4321807_5	234267.Acid_0791	1.904e-53	198.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
HFD2_k127_4321807_1	1267535.KB906767_gene1039	6.995e-114	385.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia	204432|Acidobacteriia	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_4321807_0	234267.Acid_0778	6.589e-133	433.0	COG2379@1|root,COG2379@2|Bacteria,3Y2XC@57723|Acidobacteria	57723|Acidobacteria	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HFD2_k127_434090_13	1500257.JQNM01000011_gene5599	1.864e-18	92.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TSHP@28211|Alphaproteobacteria,4B7UI@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_434090_3	1123389.ATXJ01000021_gene1077	1.425e-151	494.0	COG2148@1|root,COG2148@2|Bacteria,1WIX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GM	COGs COG2148 Sugar transferase involved in lipopolysaccharide synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD2_k127_434090_0	234267.Acid_2965	1.421e-234	739.0	COG0628@1|root,COG0628@2|Bacteria,3Y6C3@57723|Acidobacteria	57723|Acidobacteria	T	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_434090_5	234267.Acid_2403	1.553e-116	384.0	COG0745@1|root,COG0745@2|Bacteria,3Y4FA@57723|Acidobacteria	57723|Acidobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_434090_4	1267535.KB906767_gene897	2.39e-133	430.0	COG5002@1|root,COG5002@2|Bacteria,3Y99C@57723|Acidobacteria,2JP5N@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_434090_2	1267535.KB906767_gene871	5.183e-156	497.0	COG1398@1|root,COG1398@2|Bacteria,3Y6GE@57723|Acidobacteria	57723|Acidobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_434090_8	1144305.PMI02_01782	1.069e-61	223.0	COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,2TVDN@28211|Alphaproteobacteria,2K2S7@204457|Sphingomonadales	204457|Sphingomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_434090_1	234267.Acid_1183	5.846e-199	637.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6RM@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_434090_6	234267.Acid_6850	1.058e-104	346.0	COG1011@1|root,COG1011@2|Bacteria,3Y93J@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_434090_14	1123377.AUIV01000004_gene1893	1.69e-08	66.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,1S67S@1236|Gammaproteobacteria,1X75K@135614|Xanthomonadales	135614|Xanthomonadales	E	Lactoylglutathione lyase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_434090_10	861299.J421_0551	1.709e-26	113.0	2DNQD@1|root,32YJR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
HFD2_k127_434090_7	1379270.AUXF01000002_gene1145	7.384e-86	300.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_434090_11	136993.KB900627_gene392	8.592e-25	117.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_434090_9	234267.Acid_4061	3.012e-34	132.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,Dala_Dala_lig_C,RimK
HFD2_k127_4386441_0	234267.Acid_4268	3.098e-134	453.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_4398512_12	868595.Desca_1553	2.258e-12	77.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,262ZF@186807|Peptococcaceae	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4398512_9	1382358.JHVN01000009_gene3291	1.426e-27	121.0	COG3764@1|root,COG3764@2|Bacteria,1V1RS@1239|Firmicutes,4HFWK@91061|Bacilli,21X69@150247|Anoxybacillus	91061|Bacilli	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_4398512_8	1267535.KB906767_gene2937	5.262e-33	137.0	2FBCE@1|root,343I9@2|Bacteria,3Y8Q4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4398512_7	234267.Acid_7445	4.55e-62	224.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4398512_10	1121405.dsmv_1117	6.829e-21	106.0	COG1503@1|root,COG1503@2|Bacteria,1MXX2@1224|Proteobacteria,42U2M@68525|delta/epsilon subdivisions,2WQS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4398512_4	234267.Acid_7494	1.505e-102	353.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_4398512_5	251229.Chro_0517	1.525e-77	273.0	COG0463@1|root,COG0463@2|Bacteria,1G4JF@1117|Cyanobacteria,3VME5@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4398512_6	44454.NF84_19260	1.355e-63	230.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,2336J@1762|Mycobacteriaceae	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HFD2_k127_4398512_3	234267.Acid_5197	1.768e-131	428.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_6,HTH_18
HFD2_k127_4398512_0	1267535.KB906767_gene3229	8.423e-201	630.0	COG0192@1|root,COG0192@2|Bacteria,3Y45C@57723|Acidobacteria,2JJ0A@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_4398512_1	234267.Acid_2025	1.733e-157	507.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria	57723|Acidobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD2_k127_4398512_2	234267.Acid_1549	8.7e-148	472.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HFD2_k127_4398512_11	1278073.MYSTI_02102	1.159e-12	79.0	29921@1|root,2ZW5I@2|Bacteria,1RE74@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_5	682795.AciX8_4008	2.743e-62	221.0	COG1954@1|root,COG1954@2|Bacteria,3Y8K9@57723|Acidobacteria,2JNDH@204432|Acidobacteriia	204432|Acidobacteriia	K	Glycerol-3-phosphate responsive antiterminator	-	-	-	ko:K02443	-	-	-	-	ko00000,ko03000	-	-	-	G3P_antiterm
HFD2_k127_4403537_4	91604.ID47_07035	9.122e-79	272.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD2_k127_4403537_1	1082931.KKY_2582	8.178e-217	690.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_4403537_11	1944.JOAZ01000003_gene5235	5.189e-16	87.0	COG2128@1|root,COG2128@2|Bacteria,2IBNX@201174|Actinobacteria	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_4403537_10	136993.KB900627_gene393	6.74e-26	121.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_8	136993.KB900627_gene392	5.251e-30	132.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_2	234267.Acid_0687	1.638e-88	314.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	2|Bacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
HFD2_k127_4403537_0	861299.J421_0317	9.251e-223	711.0	28JZZ@1|root,2Z9PZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_9	1121948.AUAC01000007_gene330	1.017e-27	127.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,43XAS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4403537_12	555793.WSK_3225	7.177e-13	75.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_3	378806.STAUR_6894	1.799e-88	303.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_4403537_6	136993.KB900627_gene392	1.283e-51	196.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4403537_7	136993.KB900627_gene392	2.665e-38	152.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4425656_1	1267535.KB906767_gene2569	7.989e-34	133.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria,2JHM1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD2_k127_4425656_2	1267535.KB906767_gene2570	1.173e-31	129.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD2_k127_4425656_3	911045.PSE_2583	1.941e-08	65.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_4425656_0	1267533.KB906733_gene3215	8.238e-111	376.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_4438655_4	234267.Acid_1306	8.582e-42	171.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_4438655_3	1121439.dsat_0494	1.357e-51	190.0	COG0500@1|root,COG2226@2|Bacteria,1R1BM@1224|Proteobacteria,43D8C@68525|delta/epsilon subdivisions,2X8EZ@28221|Deltaproteobacteria,2ME7Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_4438655_1	234267.Acid_1222	1.27e-72	254.0	COG3358@1|root,COG3358@2|Bacteria,3Y4K1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
HFD2_k127_4438655_2	1380394.JADL01000012_gene824	1.292e-68	244.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,2JWBN@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_4438655_0	1340493.JNIF01000003_gene4028	1.47e-99	337.0	COG0148@1|root,COG0148@2|Bacteria,3Y2IT@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD2_k127_4442174_2	1033991.RLEG12_01815	9.894e-11	69.0	COG1989@1|root,COG1989@2|Bacteria,1PCGH@1224|Proteobacteria,2VA06@28211|Alphaproteobacteria,4BI44@82115|Rhizobiaceae	28211|Alphaproteobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HFD2_k127_4442174_1	1267534.KB906755_gene4087	1.783e-47	181.0	COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria,2JJ9A@204432|Acidobacteriia	204432|Acidobacteriia	U	flp pilus assembly protein CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_4442174_0	1340493.JNIF01000003_gene3295	8.593e-101	347.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD2_k127_4442174_3	643562.Daes_2911	1.473e-06	59.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MAS2@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
HFD2_k127_4447967_3	639030.JHVA01000001_gene1884	2.172e-29	131.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4447967_1	234267.Acid_0041	5.216e-188	609.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4447967_0	234267.Acid_0041	4.51e-194	627.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4447967_2	234267.Acid_5880	1.526e-50	186.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TIR_2
HFD2_k127_4461170_1	1267535.KB906767_gene3834	9.171e-104	360.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_4461170_2	240015.ACP_2126	3.084e-44	163.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_4461170_3	1123242.JH636435_gene2796	5.874e-34	137.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_4461170_0	234267.Acid_3914	2.461e-134	450.0	COG2010@1|root,COG3386@1|root,COG2010@2|Bacteria,COG3386@2|Bacteria,3Y9A6@57723|Acidobacteria	2|Bacteria	C	PFAM SMP-30 Gluconolaconase	peaA	GO:0003674,GO:0003824,GO:0004341,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016051,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:1901576	1.4.9.1	ko:K08685,ko:K14274	ko00040,ko00680,ko01120,map00040,map00680,map01120	-	R00606,R02427	RC00189,RC00713	ko00000,ko00001,ko01000	-	-	-	Cu2_monoox_C,Cu2_monooxygen,Dehyd-heme_bind,Qn_am_d_aII,Qn_am_d_aIII,Qn_am_d_aIV,SGL
HFD2_k127_4462415_7	1267535.KB906767_gene4777	2.029e-108	365.0	COG4585@1|root,COG4585@2|Bacteria,3Y59R@57723|Acidobacteria	57723|Acidobacteria	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HATPase_c,HisKA_3
HFD2_k127_4462415_14	234267.Acid_1603	2.259e-89	299.0	COG2197@1|root,COG2197@2|Bacteria,3Y6T2@57723|Acidobacteria	57723|Acidobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_4462415_15	234267.Acid_3715	1.751e-83	296.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_4462415_9	204669.Acid345_0983	1.46e-102	366.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_4462415_5	1123257.AUFV01000003_gene1228	2.227e-113	373.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1X3VH@135614|Xanthomonadales	135614|Xanthomonadales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HFD2_k127_4462415_6	1382359.JIAL01000001_gene2843	2.393e-113	374.0	COG2041@1|root,COG2041@2|Bacteria,3Y2X4@57723|Acidobacteria,2JHNI@204432|Acidobacteriia	204432|Acidobacteriia	S	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HFD2_k127_4462415_17	234267.Acid_7537	2.154e-78	268.0	COG2717@1|root,COG2717@2|Bacteria,3Y58Y@57723|Acidobacteria	57723|Acidobacteria	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HFD2_k127_4462415_18	1380355.JNIJ01000025_gene1187	3.904e-77	267.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,3JRP5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	MA20_37085	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_4462415_33	1267535.KB906767_gene3834	1.196e-05	50.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_4462415_23	1296990.H845_3279	1.143e-40	153.0	COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,2UEV4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM death-on-curing family protein	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
HFD2_k127_4462415_32	309807.SRU_1410	2.599e-06	50.0	291YZ@1|root,2ZPIG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4462415_27	1218075.BAYA01000011_gene3502	4.966e-15	86.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,1K0Y6@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD2_k127_4462415_25	862908.BMS_0818	1.002e-27	115.0	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,42UWP@68525|delta/epsilon subdivisions,2MUMA@213481|Bdellovibrionales,2WRE4@28221|Deltaproteobacteria	213481|Bdellovibrionales	U	Small Multidrug Resistance protein	-	-	-	ko:K03297,ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HFD2_k127_4462415_16	1101191.KI912577_gene3851	2.986e-82	287.0	COG0451@1|root,COG0451@2|Bacteria,1MVGI@1224|Proteobacteria,2VFSD@28211|Alphaproteobacteria,1JTN1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
HFD2_k127_4462415_1	234267.Acid_0769	0.0	1171.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,3Y61D@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HFD2_k127_4462415_0	234267.Acid_7263	0.0	1409.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_4462415_3	234267.Acid_7262	1.353e-137	444.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4462415_20	234267.Acid_7261	9.45e-49	183.0	COG1266@1|root,COG1266@2|Bacteria,3Y54S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_4462415_10	234267.Acid_0579	2.114e-101	336.0	COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria	57723|Acidobacteria	G	PFAM YdjC family protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
HFD2_k127_4462415_11	1340493.JNIF01000003_gene2492	7.909e-94	320.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD2_k127_4462415_12	234267.Acid_0581	1.199e-92	312.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_4462415_8	1267535.KB906767_gene3562	9.739e-104	345.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_4462415_4	234267.Acid_0583	6.244e-114	375.0	COG3191@1|root,COG3191@2|Bacteria,3Y6EN@57723|Acidobacteria	57723|Acidobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HFD2_k127_4462415_19	204669.Acid345_2199	1.007e-54	207.0	COG1725@1|root,COG1725@2|Bacteria,3Y8PU@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07978	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD2_k127_4462415_29	204669.Acid345_2334	6.645e-12	76.0	COG2948@1|root,COG2948@2|Bacteria,3Y81Q@57723|Acidobacteria,2JN9S@204432|Acidobacteriia	204432|Acidobacteriia	U	multi-organism process	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
HFD2_k127_4462415_13	234267.Acid_0909	2.035e-89	302.0	COG0565@1|root,COG0565@2|Bacteria,3Y4F6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA rRNA methyltransferase, SpoU	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_4462415_21	234267.Acid_6222	1.596e-45	168.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria	57723|Acidobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD2_k127_4462415_22	269799.Gmet_1627	3.69e-43	162.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,43UNX@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD2_k127_4462415_2	1267535.KB906767_gene3806	0.0	1035.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria,2JI4G@204432|Acidobacteriia	204432|Acidobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD2_k127_4462415_24	1244869.H261_09247	1.004e-39	150.0	COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,2VGD6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_4462415_26	111780.Sta7437_4031	5.627e-20	91.0	COG4118@1|root,COG4118@2|Bacteria,1G9BA@1117|Cyanobacteria,3VKQ9@52604|Pleurocapsales	1117|Cyanobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_4462415_31	234267.Acid_4423	2.32e-07	53.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4499792_1	234267.Acid_5375	1.16e-128	424.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4499792_4	351160.LRC339	4.763e-50	187.0	COG3920@1|root,arCOG02335@2157|Archaea,2Y7UT@28890|Euryarchaeota,2NBMR@224756|Methanomicrobia	224756|Methanomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
HFD2_k127_4499792_2	1123508.JH636446_gene6357	2.908e-90	321.0	COG4191@1|root,COG4191@2|Bacteria,2J25T@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HFD2_k127_4499792_3	234267.Acid_6420	1.617e-72	256.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4499792_0	1267535.KB906767_gene880	3.07e-200	645.0	COG0612@1|root,COG0612@2|Bacteria,3Y2FB@57723|Acidobacteria,2JHWY@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
HFD2_k127_45182_2	331869.BAL199_13840	2.379e-16	84.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,LZ_Tnp_IS481,rve
HFD2_k127_45182_0	1121033.AUCF01000003_gene3141	5.998e-106	352.0	28MWI@1|root,2ZB3T@2|Bacteria,1RAPA@1224|Proteobacteria,2U1GH@28211|Alphaproteobacteria,2JVU6@204441|Rhodospirillales	204441|Rhodospirillales	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
HFD2_k127_45182_1	1038858.AXBA01000050_gene681	1.381e-46	170.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3F29B@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HFD2_k127_4532967_10	1304275.C41B8_12750	1.498e-95	316.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,1RRRD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	Belongs to the IlvD Edd family	IV02_10650	-	4.2.1.25,4.2.1.9	ko:K01687,ko:K13875	ko00053,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00053,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02522,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_4532967_7	627192.SLG_26300	1.061e-116	384.0	2EVK9@1|root,33P0C@2|Bacteria,1P9RH@1224|Proteobacteria,2UVJR@28211|Alphaproteobacteria,2KE01@204457|Sphingomonadales	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4532967_15	627192.SLG_26300	1.248e-68	245.0	2EVK9@1|root,33P0C@2|Bacteria,1P9RH@1224|Proteobacteria,2UVJR@28211|Alphaproteobacteria,2KE01@204457|Sphingomonadales	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4532967_11	886293.Sinac_5619	2.482e-95	321.0	COG0657@1|root,COG0657@2|Bacteria,2IZAJ@203682|Planctomycetes	203682|Planctomycetes	I	Alpha beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_4532967_20	861299.J421_1875	1.394e-27	118.0	COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Cupin_2,Haem_degrading
HFD2_k127_4532967_17	1229485.AMYV01000005_gene4447	1.249e-54	204.0	COG3391@1|root,COG3391@2|Bacteria,1P0CV@1224|Proteobacteria,1RP6U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4532967_4	234267.Acid_4372	2.202e-154	499.0	COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_4532967_21	234267.Acid_1497	6.504e-06	51.0	2DF57@1|root,2ZQIC@2|Bacteria,3Y8V0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
HFD2_k127_4532967_12	234267.Acid_1601	1.639e-90	310.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD2_k127_4532967_19	1366050.N234_32400	1.031e-30	129.0	2CBFC@1|root,32RYI@2|Bacteria,1N0T4@1224|Proteobacteria,2VU07@28216|Betaproteobacteria,1KAKE@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4532967_1	1267535.KB906767_gene2980	1.241e-237	747.0	COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria	2|Bacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_4532967_3	251221.35213265	1.926e-157	503.0	COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_4532967_8	234267.Acid_5045	1.19e-115	379.0	COG1082@1|root,COG1082@2|Bacteria,3Y61S@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_4532967_0	1267535.KB906767_gene2195	6.647e-239	751.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	exaA	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_4532967_13	234267.Acid_0539	1.086e-76	266.0	COG2010@1|root,COG2010@2|Bacteria,3Y6G2@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_4532967_6	1267535.KB906767_gene192	3.195e-119	389.0	COG1082@1|root,COG1082@2|Bacteria,3Y79W@57723|Acidobacteria	57723|Acidobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_4532967_5	234267.Acid_3771	5.195e-131	434.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4532967_2	1038860.AXAP01000018_gene3108	8.699e-158	517.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_4532967_9	97096.XP_007790920.1	2.291e-107	370.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_4532967_16	680198.SCAB_13971	1.178e-59	223.0	COG1062@1|root,COG1062@2|Bacteria,2H5QJ@201174|Actinobacteria	2|Bacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_4532967_14	479434.Sthe_2711	2.098e-76	262.0	COG1335@1|root,COG1335@2|Bacteria,2G922@200795|Chloroflexi,27YMA@189775|Thermomicrobia	189775|Thermomicrobia	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD2_k127_4547512_30	1267535.KB906767_gene3955	1.66e-24	108.0	COG0628@1|root,COG0628@2|Bacteria,3Y4YN@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_4547512_32	641491.DND132_2920	2.215e-15	89.0	COG4249@1|root,COG4249@2|Bacteria,1R0S6@1224|Proteobacteria,43D0K@68525|delta/epsilon subdivisions,2X88G@28221|Deltaproteobacteria,2M8Z5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD2_k127_4547512_34	743836.AYNA01000121_gene2529	4.006e-05	56.0	2CAG0@1|root,3405J@2|Bacteria,1NXV9@1224|Proteobacteria,2UT91@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_27	1335760.ASTG01000003_gene1750	1.202e-27	122.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_28	1209072.ALBT01000032_gene2123	3.656e-26	115.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_17	502025.Hoch_6884	1.022e-67	241.0	COG2169@1|root,COG4978@1|root,COG2169@2|Bacteria,COG4978@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	MA20_43725	-	2.1.1.63,3.1.31.1,3.2.2.21	ko:K01174,ko:K07720,ko:K10778,ko:K13529,ko:K13652,ko:K15051	ko02020,ko03410,map02020,map03410	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko03000,ko03400	-	-	-	GyrI-like,HTH_18,Polyketide_cyc2
HFD2_k127_4547512_36	531844.FIC_01594	0.0007445	47.0	2DSUT@1|root,33HH9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_1	1267535.KB906767_gene3954	6.805e-265	827.0	COG4799@1|root,COG4799@2|Bacteria,3Y3DC@57723|Acidobacteria,2JIP2@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD2_k127_4547512_25	1340493.JNIF01000003_gene1464	9.777e-40	154.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_4547512_35	639030.JHVA01000001_gene697	0.0003183	51.0	2FDUY@1|root,345VJ@2|Bacteria,3Y8EG@57723|Acidobacteria,2JNMJ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_11	1267535.KB906767_gene2599	9.48e-121	394.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JMQ0@204432|Acidobacteriia	204432|Acidobacteriia	F	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	-	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_4547512_18	234267.Acid_4781	1.316e-67	236.0	COG0237@1|root,COG0237@2|Bacteria,3Y4R2@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HFD2_k127_4547512_14	1267535.KB906767_gene2601	2.994e-114	379.0	COG0265@1|root,COG0265@2|Bacteria,3Y3HE@57723|Acidobacteria,2JHN5@204432|Acidobacteriia	204432|Acidobacteriia	O	peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_4547512_12	234267.Acid_1025	5.768e-115	383.0	COG0738@1|root,COG0738@2|Bacteria,3Y6YP@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4547512_13	234267.Acid_1026	1.231e-114	385.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD2_k127_4547512_29	234267.Acid_1028	4.553e-26	109.0	COG2331@1|root,COG2331@2|Bacteria,3Y92S@57723|Acidobacteria	57723|Acidobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD2_k127_4547512_31	1123072.AUDH01000043_gene1793	8.323e-16	83.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
HFD2_k127_4547512_22	1340493.JNIF01000004_gene1005	9.097e-50	194.0	295K0@1|root,2ZSXG@2|Bacteria,3Y94Y@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4547512_2	234267.Acid_0738	7.83e-218	694.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HFD2_k127_4547512_7	234267.Acid_0480	1.725e-155	513.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_4547512_15	234267.Acid_3917	4.199e-114	371.0	COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD2_k127_4547512_21	234267.Acid_4266	5.377e-61	218.0	COG4219@1|root,COG4219@2|Bacteria,3Y7K7@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD2_k127_4547512_33	234267.Acid_3917	3.941e-14	74.0	COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD2_k127_4547512_19	1267534.KB906755_gene4735	1.97e-66	229.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_4547512_23	448385.sce5997	2.855e-46	177.0	COG2207@1|root,COG2207@2|Bacteria,1R4RI@1224|Proteobacteria,42VD2@68525|delta/epsilon subdivisions,2WRMS@28221|Deltaproteobacteria,2Z0FP@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HFD2_k127_4547512_37	984262.SGRA_2212	0.0009165	42.0	COG2318@1|root,COG2318@2|Bacteria,4NVXM@976|Bacteroidetes	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4547512_4	251221.35211983	2.55e-170	564.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_4547512_10	99598.Cal7507_1292	1.08e-122	403.0	COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HTYB@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_4547512_5	234267.Acid_2220	9.754e-168	545.0	COG1472@1|root,COG1472@2|Bacteria,3Y6UR@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD2_k127_4547512_0	1267533.KB906734_gene3886	1.791e-282	882.0	COG0247@1|root,COG0247@2|Bacteria,3Y3K8@57723|Acidobacteria,2JKGH@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD2_k127_4547512_8	234267.Acid_1371	1.309e-142	458.0	COG0451@1|root,COG0451@2|Bacteria,3Y3T4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_4547512_24	234267.Acid_5498	3.731e-41	154.0	COG2363@1|root,COG2363@2|Bacteria,3Y82H@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
HFD2_k127_4547512_16	1340493.JNIF01000003_gene4320	1.354e-88	305.0	COG1321@1|root,COG1321@2|Bacteria,3Y5SN@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HFD2_k127_4547512_3	234267.Acid_6500	5.758e-175	573.0	COG2234@1|root,COG2234@2|Bacteria,3Y4CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_4547512_9	234267.Acid_1761	3.914e-142	464.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria	57723|Acidobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HFD2_k127_4547512_6	1267535.KB906767_gene5202	2.729e-167	551.0	COG0249@1|root,COG0249@2|Bacteria,3Y48T@57723|Acidobacteria,2JKU6@204432|Acidobacteriia	204432|Acidobacteriia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
HFD2_k127_457788_5	1267535.KB906767_gene3578	1.488e-21	95.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_457788_0	234267.Acid_1658	2.572e-283	884.0	COG1297@1|root,COG1297@2|Bacteria,3Y2UT@57723|Acidobacteria	57723|Acidobacteria	S	Oligopeptide transporter OPT	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_457788_1	1340493.JNIF01000004_gene331	7.047e-104	341.0	COG0603@1|root,COG0603@2|Bacteria,3Y3RP@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HFD2_k127_457788_2	234267.Acid_0302	1.343e-98	326.0	COG0602@1|root,COG0602@2|Bacteria,3Y2UA@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_457788_3	234267.Acid_0296	6.326e-52	190.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria	57723|Acidobacteria	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HFD2_k127_4580282_1	234267.Acid_7637	2.764e-126	414.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_4580282_0	234267.Acid_6511	1.713e-212	676.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria	57723|Acidobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD2_k127_4585646_21	1267535.KB906767_gene4268	1.36e-33	133.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD2_k127_4585646_19	234267.Acid_2193	4.4e-46	173.0	COG1595@1|root,COG1595@2|Bacteria,3Y863@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4585646_26	1122970.AUHC01000020_gene2415	0.0001195	53.0	COG4944@1|root,COG4944@2|Bacteria,1N3C7@1224|Proteobacteria,2VGWG@28211|Alphaproteobacteria,2K5Z0@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HFD2_k127_4585646_25	1123393.KB891316_gene1281	1.128e-09	61.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KSTW@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_4585646_22	1382359.JIAL01000001_gene354	1.964e-21	100.0	COG0071@1|root,COG0071@2|Bacteria,3Y8FE@57723|Acidobacteria,2JNDQ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934,HSP20
HFD2_k127_4585646_12	251229.Chro_3389	7.062e-77	262.0	2CYFR@1|root,32T44@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HFD2_k127_4585646_5	102129.Lepto7375DRAFT_0197	1.478e-178	566.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_4585646_17	926566.Terro_2182	7.443e-52	190.0	296ZZ@1|root,2ZU8H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4585646_9	1123368.AUIS01000028_gene1327	1.946e-107	355.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_4585646_1	1173024.KI912148_gene3732	1.704e-258	819.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_4585646_10	402626.Rpic_4367	3.203e-92	316.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,1KBW0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD2_k127_4585646_20	1267535.KB906767_gene5038	1.037e-42	174.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria,2JI98@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_4585646_2	1242864.D187_006805	1.236e-240	753.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD2_k127_4585646_8	452637.Oter_2672	8.828e-122	405.0	COG2271@1|root,COG2271@2|Bacteria,46UQA@74201|Verrucomicrobia,3K8MQ@414999|Opitutae	414999|Opitutae	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4585646_3	1267535.KB906767_gene841	4.073e-229	721.0	COG0591@1|root,COG0591@2|Bacteria,3Y6FC@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_4585646_18	1267535.KB906767_gene2875	6.47e-49	189.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4585646_4	234267.Acid_6681	1.702e-218	685.0	COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HFD2_k127_4585646_7	234267.Acid_6682	7.938e-142	458.0	COG1294@1|root,COG1294@2|Bacteria,3Y3UT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HFD2_k127_4585646_15	69395.JQLZ01000005_gene3645	2.101e-59	216.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4585646_0	1340493.JNIF01000003_gene2088	0.0	1065.0	COG4772@1|root,COG4772@2|Bacteria,3Y47K@57723|Acidobacteria	57723|Acidobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_4585646_13	234267.Acid_4171	1.552e-68	243.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4585646_11	1173024.KI912148_gene3333	8.395e-84	283.0	COG0412@1|root,COG0412@2|Bacteria,1G1CY@1117|Cyanobacteria,1JJI9@1189|Stigonemataceae	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD2_k127_4585646_6	1346791.M529_18425	1.267e-152	505.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales	204457|Sphingomonadales	CG	Dehydrogenase	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_4585646_23	555793.WSK_4047	4.119e-21	104.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4585646_16	627192.SLG_04410	2.849e-58	208.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales	204457|Sphingomonadales	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_4586336_4	269796.Rru_A3126	4.123e-15	78.0	COG5653@1|root,COG5653@2|Bacteria,1RDJC@1224|Proteobacteria,2U32H@28211|Alphaproteobacteria,2JX4S@204441|Rhodospirillales	204441|Rhodospirillales	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HFD2_k127_4586336_3	1089552.KI911559_gene3664	4.157e-21	95.0	COG0236@1|root,COG0236@2|Bacteria,1N83X@1224|Proteobacteria,2UKMX@28211|Alphaproteobacteria,2JUQN@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD2_k127_4586336_2	1158760.AQXP01000053_gene1475	4.327e-64	229.0	COG1073@1|root,COG1073@2|Bacteria,1RDA0@1224|Proteobacteria,1S647@1236|Gammaproteobacteria,1WYMV@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_4586336_1	883126.HMPREF9710_00670	2.408e-90	308.0	COG1073@1|root,COG1073@2|Bacteria,1R61B@1224|Proteobacteria,2VQGB@28216|Betaproteobacteria,474CE@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HFD2_k127_4586336_0	1123060.JONP01000016_gene5450	2.242e-185	603.0	COG0476@1|root,COG0778@1|root,COG0476@2|Bacteria,COG0778@2|Bacteria,1QUMS@1224|Proteobacteria,2TT9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD2_k127_4609767_12	234267.Acid_7757	6.077e-36	140.0	COG1430@1|root,COG1430@2|Bacteria,3Y5J5@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD2_k127_4609767_8	485913.Krac_12208	5.971e-70	240.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD2_k127_4609767_1	234267.Acid_1571	5.571e-234	730.0	COG0621@1|root,COG0621@2|Bacteria,3Y362@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_4609767_13	1267535.KB906767_gene1014	8.065e-19	87.0	COG3024@1|root,COG3024@2|Bacteria,3Y603@57723|Acidobacteria	57723|Acidobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	-	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HFD2_k127_4609767_11	1267535.KB906767_gene1015	1.713e-46	174.0	COG1267@1|root,COG1267@2|Bacteria,3Y4T1@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HFD2_k127_4609767_5	234267.Acid_1568	2.213e-143	466.0	COG3391@1|root,COG3391@2|Bacteria,3Y99Z@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HFD2_k127_4609767_4	234267.Acid_1567	2.88e-144	470.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3Y466@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HFD2_k127_4609767_14	1209072.ALBT01000032_gene2078	2.914e-07	59.0	2DYRQ@1|root,34ATV@2|Bacteria,1PQUZ@1224|Proteobacteria,1ST19@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD2_k127_4609767_9	1340493.JNIF01000003_gene4796	5.578e-64	230.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HDOD,Response_reg
HFD2_k127_4609767_3	1267535.KB906767_gene938	1.585e-153	493.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria,2JHY8@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HFD2_k127_4609767_7	1267535.KB906767_gene4717	1.106e-104	346.0	COG0157@1|root,COG0157@2|Bacteria,3Y2H5@57723|Acidobacteria,2JHQE@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HFD2_k127_4609767_10	234267.Acid_2286	4.492e-54	201.0	COG0671@1|root,COG0671@2|Bacteria,3Y5F0@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD2_k127_4609767_0	1267535.KB906767_gene5052	7.855e-263	848.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HFD2_k127_4609767_6	234267.Acid_1921	2.01e-109	366.0	COG3852@1|root,COG3852@2|Bacteria,3Y9A1@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_4609767_2	234267.Acid_1922	5.321e-206	648.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_462124_4	1173023.KE650771_gene4905	5.998e-86	288.0	COG0399@1|root,COG0399@2|Bacteria,1G0IM@1117|Cyanobacteria,1JJ7R@1189|Stigonemataceae	1117|Cyanobacteria	M	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_462124_2	1267535.KB906767_gene2523	2.842e-130	423.0	COG2141@1|root,COG2141@2|Bacteria,3Y4KK@57723|Acidobacteria,2JJ9T@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM luciferase family oxidoreductase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_462124_5	234267.Acid_2033	7.101e-80	284.0	COG0666@1|root,COG0666@2|Bacteria,3Y8C5@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD2_k127_462124_1	234267.Acid_2032	1.765e-139	456.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_462124_3	379066.GAU_3134	1.108e-93	321.0	COG2133@1|root,COG2133@2|Bacteria,1ZUDS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
HFD2_k127_462124_0	234267.Acid_5827	1.73e-256	813.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_462124_9	1449080.JQMV01000003_gene721	2.174e-13	75.0	COG0745@1|root,COG0745@2|Bacteria,1WK6R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_462124_7	1340493.JNIF01000003_gene2123	4.955e-31	132.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_462124_8	234267.Acid_2741	3.249e-28	130.0	COG4219@1|root,COG4219@2|Bacteria,3Y35Z@57723|Acidobacteria	2|Bacteria	KT	Protein of unknown function (DUF3738)	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_462124_6	234267.Acid_0173	1.42e-70	249.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_4636359_2	234267.Acid_6206	1.31e-30	132.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria	57723|Acidobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
HFD2_k127_4636359_1	234267.Acid_6205	4.224e-104	363.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_4636359_0	1267535.KB906767_gene1147	4.529e-108	373.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HFD2_k127_4647505_5	1267535.KB906767_gene2475	4.316e-49	183.0	COG4733@1|root,COG4733@2|Bacteria,3Y67A@57723|Acidobacteria	57723|Acidobacteria	S	Putative phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage-tail_3
HFD2_k127_4647505_0	234267.Acid_4122	4.774e-286	904.0	COG4386@1|root,COG4386@2|Bacteria,3Y65A@57723|Acidobacteria	57723|Acidobacteria	S	tail sheath protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4647505_1	234267.Acid_4413	4.207e-162	518.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD2_k127_4647505_2	234267.Acid_4415	7.501e-154	495.0	COG0006@1|root,COG0006@2|Bacteria,3Y3I4@57723|Acidobacteria	57723|Acidobacteria	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD2_k127_4647505_7	1101195.Meth11DRAFT_1445	2.895e-31	128.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,2VVSH@28216|Betaproteobacteria,2KNE9@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4647505_4	1082931.KKY_114	5.984e-107	357.0	COG0346@1|root,COG0346@2|Bacteria,1P6TT@1224|Proteobacteria,2TQXR@28211|Alphaproteobacteria,3N6NT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15242,ko:K15975	ko00361,ko01100,ko01120,ko01220,map00361,map01100,map01120,map01220	-	R05408	RC02673	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_4647505_3	639030.JHVA01000001_gene1843	2.654e-141	463.0	COG0165@1|root,COG0165@2|Bacteria,3Y7F3@57723|Acidobacteria,2JM7C@204432|Acidobacteriia	204432|Acidobacteriia	E	Argininosuccinate lyase C-terminal	-	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HFD2_k127_4647505_6	234267.Acid_3845	2.004e-32	132.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria	57723|Acidobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_4663559_0	1198114.AciX9_1643	3.314e-148	491.0	COG5267@1|root,COG5267@2|Bacteria,3Y6EE@57723|Acidobacteria,2JMGR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_4663559_1	1198114.AciX9_1644	1.733e-117	394.0	COG4102@1|root,COG4102@2|Bacteria,3Y6D8@57723|Acidobacteria,2JKIU@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_4663559_4	204669.Acid345_3916	8.185e-63	225.0	COG0242@1|root,COG0242@2|Bacteria,3Y53A@57723|Acidobacteria,2JJFJ@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD2_k127_4663559_5	1267535.KB906767_gene1323	1.765e-49	182.0	COG2346@1|root,COG2346@2|Bacteria,3Y8TC@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_4663559_8	1122917.KB899673_gene630	5.384e-05	48.0	COG5487@1|root,COG5487@2|Bacteria,1VMQV@1239|Firmicutes,4I08P@91061|Bacilli,26ZX8@186822|Paenibacillaceae	91061|Bacilli	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HFD2_k127_4663559_2	1007104.SUS17_2461	4.675e-101	342.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,2K0QG@204457|Sphingomonadales	204457|Sphingomonadales	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD2_k127_4663559_6	136993.KB900627_gene392	2.7e-27	121.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4663559_3	251221.35214089	4.048e-76	272.0	COG1228@1|root,COG1228@2|Bacteria,1G3PN@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_4663559_7	759362.KVU_0908	4.088e-08	55.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2TSFB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_466567_0	861299.J421_0317	5e-324	1005.0	28JZZ@1|root,2Z9PZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_466567_8	66377.JOBH01000010_gene6350	7.994e-24	112.0	COG2520@1|root,COG2520@2|Bacteria,2I388@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD2_k127_466567_1	886293.Sinac_4681	1.285e-99	345.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052,ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	Abi,Exosortase_EpsH
HFD2_k127_466567_3	1340493.JNIF01000003_gene3859	2.525e-75	262.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_466567_2	1267535.KB906767_gene4268	1.628e-95	324.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD2_k127_466567_6	1121448.DGI_0033	2.735e-36	148.0	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,43BJZ@68525|delta/epsilon subdivisions,2X6XU@28221|Deltaproteobacteria,2MBAK@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_466567_7	234267.Acid_7539	3.796e-30	123.0	COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria	57723|Acidobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_466567_5	1321786.HMPREF1992_00158	1.352e-43	173.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4H2HH@909932|Negativicutes	909932|Negativicutes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_466567_9	1492738.FEM21_14540	1.66e-16	87.0	COG0110@1|root,COG0110@2|Bacteria,4NNTF@976|Bacteroidetes,1I232@117743|Flavobacteriia,2NWA0@237|Flavobacterium	976|Bacteroidetes	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HFD2_k127_466567_4	1131269.AQVV01000041_gene1652	9.528e-48	178.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_4672909_7	886293.Sinac_4969	3.602e-54	199.0	29W19@1|root,30JJX@2|Bacteria,2J09K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4672909_2	234267.Acid_4310	6.976e-122	403.0	COG0664@1|root,COG1142@1|root,COG1716@1|root,COG0664@2|Bacteria,COG1142@2|Bacteria,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	2.7.11.1,2.7.2.1	ko:K00925,ko:K08884,ko:K11894	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko01001,ko02044	3.A.23.1	-	-	FHA,Fer4_7,Pkinase,Pyr_redox_2,Pyr_redox_3,Yop-YscD_cpl,cNMP_binding
HFD2_k127_4672909_3	575540.Isop_3158	1.275e-82	285.0	COG0664@1|root,COG1142@1|root,COG3383@1|root,COG0664@2|Bacteria,COG1142@2|Bacteria,COG3383@2|Bacteria,2IX98@203682|Planctomycetes	203682|Planctomycetes	CT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,cNMP_binding
HFD2_k127_4672909_0	479435.Kfla_2118	1.172e-145	481.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2GMMC@201174|Actinobacteria,4DPP6@85009|Propionibacteriales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HFD2_k127_4672909_6	234267.Acid_4315	4.706e-61	230.0	2BF9B@1|root,32926@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HFD2_k127_4672909_1	234267.Acid_4318	2.311e-129	429.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_4672909_5	204669.Acid345_4119	1.708e-70	247.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_4672909_4	1144275.COCOR_04000	1.887e-79	284.0	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1RAHZ@1224|Proteobacteria,42UGY@68525|delta/epsilon subdivisions,2WQPI@28221|Deltaproteobacteria,2YUG9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
HFD2_k127_4682070_2	234267.Acid_0177	8.689e-164	520.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD2_k127_4682070_0	1340493.JNIF01000003_gene3616	2.062e-199	636.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene3616|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4682070_11	234267.Acid_5377	1.222e-34	139.0	COG3764@1|root,COG3764@2|Bacteria,3Y5NI@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase C60, sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_4682070_13	1267535.KB906767_gene2937	7.81e-26	117.0	2FBCE@1|root,343I9@2|Bacteria,3Y8Q4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4682070_15	401053.AciPR4_1213	1.173e-15	91.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria,2JI2I@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4682070_8	1382359.JIAL01000001_gene327	5.659e-63	228.0	COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria,2JJ2B@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HFD2_k127_4682070_17	330214.NIDE3888	8.154e-07	56.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
HFD2_k127_4682070_6	671143.DAMO_0822	4.268e-109	377.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HFD2_k127_4682070_4	671143.DAMO_0821	4.669e-125	411.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HFD2_k127_4682070_10	1379698.RBG1_1C00001G0781	7.729e-44	163.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HFD2_k127_4682070_3	240016.ABIZ01000001_gene3871	5.487e-153	496.0	COG0114@1|root,COG0114@2|Bacteria,46SFC@74201|Verrucomicrobia,2IVK5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Fumarase C C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FumaraseC_C,Lyase_1
HFD2_k127_4682070_9	661478.OP10G_4550	1.257e-50	181.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_4682070_5	1459636.NTE_00447	6.636e-110	364.0	COG3832@1|root,arCOG05261@2157|Archaea	2157|Archaea	H	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_4682070_1	1267535.KB906767_gene1287	7.173e-166	537.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_4682070_14	234267.Acid_5627	6.083e-24	107.0	COG0662@1|root,COG0662@2|Bacteria,3Y8MJ@57723|Acidobacteria	57723|Acidobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4682070_16	1267533.KB906734_gene3683	2.657e-11	69.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD2_k127_4685313_4	1340493.JNIF01000003_gene1646	2.875e-99	327.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HFD2_k127_4685313_0	1267535.KB906767_gene4284	4.411e-312	968.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria,2JIAG@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HFD2_k127_4685313_3	1267535.KB906767_gene4285	7.372e-176	561.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD2_k127_4685313_5	1267535.KB906767_gene4286	8.688e-59	209.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria,2JJ8B@204432|Acidobacteriia	204432|Acidobacteriia	C	plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD2_k127_4685313_6	1340493.JNIF01000003_gene1642	1.472e-41	154.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD2_k127_4685313_1	1267535.KB906767_gene4288	4.076e-255	799.0	COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria,2JIG7@204432|Acidobacteriia	204432|Acidobacteriia	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HFD2_k127_4685313_2	234267.Acid_0119	1.889e-188	597.0	COG1008@1|root,COG1008@2|Bacteria,3Y312@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD2_k127_4696616_0	1267535.KB906767_gene2162	7.26e-246	769.0	COG1069@1|root,COG1069@2|Bacteria,3Y3B6@57723|Acidobacteria,2JI84@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Carbohydrate kinase	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_4696616_3	1382359.JIAL01000001_gene1003	8.834e-98	325.0	COG0235@1|root,COG0235@2|Bacteria,3Y3W2@57723|Acidobacteria,2JHR0@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Class II aldolase	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
HFD2_k127_4696616_2	234267.Acid_1458	2.485e-145	470.0	COG2017@1|root,COG2017@2|Bacteria,3Y3D2@57723|Acidobacteria	57723|Acidobacteria	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD2_k127_4696616_5	234267.Acid_5130	1.567e-79	279.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_4696616_1	234267.Acid_3641	1.609e-167	530.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	3.6.3.38	ko:K07214,ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	Esterase
HFD2_k127_4696616_4	452637.Oter_3223	1.347e-85	287.0	COG3507@1|root,COG3507@2|Bacteria,46U6F@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4715147_3	234267.Acid_1280	1.331e-30	125.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_4715147_2	234267.Acid_1279	4.443e-133	435.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria	57723|Acidobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD2_k127_4715147_0	1267535.KB906767_gene4738	1.475e-201	640.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria,2JHJC@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD2_k127_4715147_4	234267.Acid_1277	2.361e-26	111.0	COG1862@1|root,COG1862@2|Bacteria,3Y5GK@57723|Acidobacteria	57723|Acidobacteria	U	Preprotein translocase, YajC	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD2_k127_4715147_1	1267535.KB906767_gene4736	2.002e-171	542.0	COG0343@1|root,COG0343@2|Bacteria,3Y3CP@57723|Acidobacteria,2JISV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD2_k127_4743319_2	1267535.KB906767_gene4837	7.08e-95	340.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_4743319_4	1267535.KB906767_gene1491	2.925e-37	142.0	COG2127@1|root,COG2127@2|Bacteria,3Y85A@57723|Acidobacteria	57723|Acidobacteria	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD2_k127_4743319_3	1267535.KB906767_gene1557	5.374e-90	300.0	COG0009@1|root,COG0009@2|Bacteria,3Y43Z@57723|Acidobacteria,2JI37@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
HFD2_k127_4743319_0	1267535.KB906767_gene1558	1.005e-292	908.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,3Y3YD@57723|Acidobacteria,2JIG8@204432|Acidobacteriia	204432|Acidobacteriia	E	homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
HFD2_k127_4743319_1	234267.Acid_7671	6.548e-106	353.0	COG1718@1|root,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4743319_5	1267535.KB906767_gene3359	7.549e-13	70.0	2EB4K@1|root,33CHY@2|Bacteria,3Y5VG@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4743319_6	204669.Acid345_2578	7.597e-12	67.0	COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	57723|Acidobacteria	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_4745007_11	1340493.JNIF01000004_gene1039	4.442e-26	111.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	COX3
HFD2_k127_4745007_1	1267535.KB906767_gene1092	1.28e-260	814.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria,2JIRX@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_4745007_4	1267535.KB906767_gene1093	2.778e-122	399.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria,2JHRF@204432|Acidobacteriia	204432|Acidobacteriia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HFD2_k127_4745007_7	1340493.JNIF01000004_gene1036	8.633e-82	280.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4745007_5	1340493.JNIF01000004_gene1034	5.168e-113	381.0	COG4531@1|root,COG4531@2|Bacteria,3Y2X7@57723|Acidobacteria	57723|Acidobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4745007_9	1267535.KB906767_gene1097	3.263e-51	188.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_4745007_10	1340493.JNIF01000004_gene1032	2.036e-47	180.0	COG2010@1|root,COG2010@2|Bacteria,3Y3HF@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF3341
HFD2_k127_4745007_2	1267535.KB906767_gene1099	3.898e-228	716.0	COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria,2JHIK@204432|Acidobacteriia	57723|Acidobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD2_k127_4745007_0	1267535.KB906767_gene1100	0.0	1046.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria,2JI83@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HFD2_k127_4745007_6	1267535.KB906767_gene1101	1.233e-92	308.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	57723|Acidobacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD2_k127_4745007_3	1267535.KB906767_gene1102	3.029e-127	419.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_4745007_8	497964.CfE428DRAFT_2531	2.223e-70	246.0	COG1216@1|root,COG4976@1|root,COG1216@2|Bacteria,COG4976@2|Bacteria,46W0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4754731_6	234267.Acid_1288	9.659e-129	414.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD2_k127_4754731_21	1267535.KB906767_gene639	2.911e-38	145.0	COG0347@1|root,COG0347@2|Bacteria,3Y4TF@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD2_k127_4754731_9	452637.Oter_2606	2.822e-114	380.0	COG0438@1|root,COG0438@2|Bacteria,46WYS@74201|Verrucomicrobia,3K9XP@414999|Opitutae	414999|Opitutae	M	PFAM glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glycos_transf_1
HFD2_k127_4754731_16	382464.ABSI01000020_gene246	3.767e-64	228.0	COG2120@1|root,COG2120@2|Bacteria,46V8X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_4754731_13	1267535.KB906767_gene4993	1.37e-79	267.0	COG0652@1|root,COG0652@2|Bacteria,3Y4CX@57723|Acidobacteria,2JJ67@204432|Acidobacteriia	204432|Acidobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_4754731_25	1267535.KB906767_gene4265	1.307e-20	99.0	2FHRB@1|root,349IU@2|Bacteria,3Y8GP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4754731_19	1267535.KB906767_gene619	1.463e-49	182.0	COG2165@1|root,COG2165@2|Bacteria,3Y4X6@57723|Acidobacteria	57723|Acidobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
HFD2_k127_4754731_29	330214.NIDE3411	1.709e-11	77.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3411|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4754731_7	1267535.KB906767_gene3548	2.962e-119	392.0	COG1420@1|root,COG1420@2|Bacteria,3Y2JI@57723|Acidobacteria,2JI0D@204432|Acidobacteriia	204432|Acidobacteriia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HFD2_k127_4754731_17	1267535.KB906767_gene3547	2.97e-53	193.0	COG0576@1|root,COG0576@2|Bacteria,3Y54K@57723|Acidobacteria,2JJMY@204432|Acidobacteriia	204432|Acidobacteriia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD2_k127_4754731_5	234267.Acid_0734	4.823e-160	511.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_4754731_2	1267535.KB906767_gene3841	1.155e-200	646.0	COG1640@1|root,COG1640@2|Bacteria,3Y6TQ@57723|Acidobacteria	57723|Acidobacteria	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD2_k127_4754731_11	1267535.KB906767_gene3776	8.52e-85	290.0	COG0377@1|root,COG0377@2|Bacteria,3Y475@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD2_k127_4754731_26	234267.Acid_1621	3.432e-20	101.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,CHAT,LCAT
HFD2_k127_4754731_4	1038860.AXAP01000018_gene3108	5.251e-164	538.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_4754731_10	1267535.KB906767_gene1304	2.915e-112	367.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria,2JINE@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_4754731_8	234267.Acid_1543	6.542e-119	400.0	2EM41@1|root,33ETI@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HFD2_k127_4754731_18	1211114.ALIP01000079_gene658	4.62e-52	191.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1X6DF@135614|Xanthomonadales	135614|Xanthomonadales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HFD2_k127_4754731_15	861299.J421_0325	4.178e-72	251.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_4754731_3	69279.BG36_01290	1.299e-191	620.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,43JAR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD2_k127_4754731_23	1267535.KB906767_gene4781	2.541e-34	132.0	COG0254@1|root,COG0254@2|Bacteria,3Y5J8@57723|Acidobacteria	57723|Acidobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD2_k127_4754731_24	1267535.KB906767_gene4633	3.326e-30	125.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria,2JNK1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4754731_28	234267.Acid_1021	3.006e-12	71.0	293BI@1|root,2ZQU6@2|Bacteria,3Y92V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4754731_12	234267.Acid_1020	1.663e-84	285.0	COG1595@1|root,COG1595@2|Bacteria,3Y6DK@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4754731_22	627192.SLG_36710	1.189e-35	141.0	COG4319@1|root,COG4319@2|Bacteria,1QUR3@1224|Proteobacteria,2TW48@28211|Alphaproteobacteria,2K85Y@204457|Sphingomonadales	204457|Sphingomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_4754731_0	204669.Acid345_0047	6.848e-233	746.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_4754731_1	234267.Acid_1175	8.369e-209	658.0	COG0531@1|root,COG0531@2|Bacteria,3Y2R3@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_4754731_14	234267.Acid_7526	5.821e-78	279.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
HFD2_k127_4754731_20	234267.Acid_3692	9.484e-39	151.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_4849020_1	234267.Acid_6848	5.48e-125	406.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	mdlC	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_4849020_3	234267.Acid_6849	4.435e-31	125.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,DHC
HFD2_k127_4849020_2	234267.Acid_5766	1.916e-77	264.0	COG1994@1|root,COG1994@2|Bacteria,3Y58P@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD2_k127_4849020_0	420662.Mpe_A3660	2.532e-125	419.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VM62@28216|Betaproteobacteria,1KIUI@119065|unclassified Burkholderiales	1224|Proteobacteria	G	PFAM Pyrrolo-quinoline quinone	-	-	1.1.2.8,1.1.5.11,1.1.5.2,1.1.9.1	ko:K00114,ko:K00117,ko:K17760,ko:K20937	ko00010,ko00030,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285,R06620	RC00066,RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_4849363_12	204669.Acid345_2989	7.741e-08	57.0	COG5002@1|root,COG5002@2|Bacteria,3Y3AX@57723|Acidobacteria,2JI3A@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_7
HFD2_k127_4849363_10	1340493.JNIF01000003_gene2123	1.053e-29	126.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4849363_7	485913.Krac_9227	4.658e-67	237.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD2_k127_4849363_6	485913.Krac_9228	3.466e-87	293.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD2_k127_4849363_0	234267.Acid_6686	3.746e-170	548.0	COG0248@1|root,COG0248@2|Bacteria,3Y3H5@57723|Acidobacteria	57723|Acidobacteria	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HFD2_k127_4849363_11	1267535.KB906767_gene3692	1.415e-15	88.0	COG5607@1|root,COG5607@2|Bacteria	2|Bacteria	F	PFAM CHAD domain containing protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HFD2_k127_4849363_9	234267.Acid_6689	3.321e-34	139.0	COG2062@1|root,COG2062@2|Bacteria,3Y5YQ@57723|Acidobacteria	57723|Acidobacteria	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD2_k127_4849363_8	1267535.KB906767_gene582	5.09e-67	237.0	COG0704@1|root,COG0704@2|Bacteria,3Y4DI@57723|Acidobacteria,2JJ5M@204432|Acidobacteriia	204432|Acidobacteriia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HFD2_k127_4849363_4	373903.Hore_21550	2.292e-106	357.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WA6K@53433|Halanaerobiales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_4849363_3	1267535.KB906767_gene584	3.609e-117	382.0	COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia	204432|Acidobacteriia	P	Phosphate transport system permease protein PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_4849363_2	1267535.KB906767_gene585	2.317e-127	414.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_4849363_1	1267535.KB906767_gene586	5.96e-134	434.0	COG0226@1|root,COG0226@2|Bacteria,3Y399@57723|Acidobacteria,2JIVU@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the PstS family	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HFD2_k127_4849363_13	1301098.PKB_2431	1.266e-05	58.0	COG2188@1|root,COG3746@1|root,COG2188@2|Bacteria,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,1T5CM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
HFD2_k127_4849363_5	1340493.JNIF01000004_gene626	2.498e-105	350.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GV@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_4913840_2	234267.Acid_1433	2.165e-74	254.0	COG2021@1|root,COG2021@2|Bacteria,3Y4EW@57723|Acidobacteria	57723|Acidobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_4913840_1	204669.Acid345_1052	2.468e-145	488.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HFD2_k127_4913840_6	204669.Acid345_1922	3.093e-44	165.0	COG2259@1|root,COG2259@2|Bacteria,3Y4XF@57723|Acidobacteria,2JMZV@204432|Acidobacteriia	204432|Acidobacteriia	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_4913840_7	1340493.JNIF01000003_gene1382	1.262e-43	167.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DUF4101,DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_4913840_5	1120950.KB892819_gene7149	9.283e-46	169.0	COG0789@1|root,COG0789@2|Bacteria,2IQ8P@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD2_k127_4913840_8	1348663.KCH_63300	2.022e-13	72.0	2EDUG@1|root,337PM@2|Bacteria,2IQCU@201174|Actinobacteria,2M5TM@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4913840_0	234267.Acid_0546	1.957e-172	549.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_4913840_4	234267.Acid_3739	7.959e-47	179.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_4913840_3	1340493.JNIF01000003_gene4649	8.312e-71	245.0	COG2010@1|root,COG2041@1|root,COG2010@2|Bacteria,COG2041@2|Bacteria,3Y7UP@57723|Acidobacteria	57723|Acidobacteria	C	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD2_k127_4945995_4	935840.JAEQ01000004_gene643	4.734e-84	291.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepQ	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_4945995_7	1463857.JOFZ01000001_gene5317	3.95e-14	85.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_4945995_0	1298920.KI911353_gene4911	2.539e-132	438.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,21ZCQ@1506553|Lachnoclostridium	1239|Firmicutes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	hacA	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_4945995_1	1123023.JIAI01000003_gene2871	2.802e-123	411.0	COG2159@1|root,COG2159@2|Bacteria,2GN9D@201174|Actinobacteria,4E0A7@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_4945995_8	658088.HMPREF0987_02681	8.532e-10	71.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,24DV7@186801|Clostridia	186801|Clostridia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_4945995_2	1403313.AXBR01000019_gene3359	3.758e-88	298.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,1ZCC8@1386|Bacillus	91061|Bacilli	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_4945995_6	1122915.AUGY01000118_gene6542	2.914e-64	229.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4I4D7@91061|Bacilli,272RG@186822|Paenibacillaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD2_k127_4945995_5	1218075.BAYA01000018_gene4732	5.422e-69	240.0	COG0684@1|root,COG0684@2|Bacteria,1QSHP@1224|Proteobacteria,2VJV8@28216|Betaproteobacteria,1K0T1@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD2_k127_4945995_3	1218075.BAYA01000018_gene4733	3.996e-88	296.0	COG0684@1|root,COG0684@2|Bacteria,1R70C@1224|Proteobacteria,2VPDE@28216|Betaproteobacteria,1K3G1@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD2_k127_4947851_3	1382359.JIAL01000001_gene2600	5.554e-19	94.0	COG0810@1|root,COG0810@2|Bacteria,3Y58J@57723|Acidobacteria,2JJPH@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_4947851_1	1267535.KB906767_gene5230	3.822e-127	429.0	COG0501@1|root,COG0501@2|Bacteria,3Y3FX@57723|Acidobacteria,2JHYR@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the peptidase M48B family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_4947851_0	1267535.KB906767_gene111	7.618e-276	855.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y2FA@57723|Acidobacteria,2JI4J@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HFD2_k127_4947851_2	1500894.JQNN01000001_gene651	6.971e-106	352.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,1MVI4@1224|Proteobacteria,2VKWG@28216|Betaproteobacteria,47691@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,YkuD
HFD2_k127_4979911_7	755732.Fluta_3751	1.973e-07	57.0	COG4870@1|root,COG4870@2|Bacteria,4NS9R@976|Bacteroidetes,1I0EV@117743|Flavobacteriia	976|Bacteroidetes	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,Peptidase_C1
HFD2_k127_4979911_1	234267.Acid_5124	4.384e-71	244.0	2DKWS@1|root,30N64@2|Bacteria,3Y5WC@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
HFD2_k127_4979911_4	309807.SRU_0658	2.14e-18	87.0	COG5606@1|root,COG5606@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HFD2_k127_4979911_8	1173020.Cha6605_1035	6.247e-07	53.0	COG4679@1|root,COG4679@2|Bacteria,1G6VG@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD2_k127_4979911_9	1346791.M529_14045	9.73e-06	53.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2UKCG@28211|Alphaproteobacteria,2K5YF@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD2_k127_4979911_5	1463820.JOGW01000007_gene1918	7.772e-16	87.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria	201174|Actinobacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_4979911_2	234267.Acid_7677	1.339e-62	220.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD2_k127_4979911_0	234267.Acid_7636	1.502e-215	700.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD2_k127_4979911_3	234267.Acid_3223	7.067e-31	132.0	28ZVZ@1|root,2ZMKG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4991665_4	234267.Acid_7273	1.553e-68	240.0	COG1482@1|root,COG1482@2|Bacteria,3Y44Q@57723|Acidobacteria	57723|Acidobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HFD2_k127_4991665_0	234267.Acid_7274	7.455e-178	564.0	COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_4991665_5	234267.Acid_7275	5.069e-64	223.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria	57723|Acidobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_4991665_2	234267.Acid_4589	1.79e-119	389.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria	57723|Acidobacteria	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_4991665_7	349520.PPE_04491	8.682e-26	116.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,4HK1H@91061|Bacilli,26YMP@186822|Paenibacillaceae	91061|Bacilli	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_4991665_6	1340493.JNIF01000003_gene1728	2.82e-47	186.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
HFD2_k127_4991665_1	234267.Acid_4586	9.86e-123	408.0	COG0860@1|root,COG3266@1|root,COG0860@2|Bacteria,COG3266@2|Bacteria,3Y3M0@57723|Acidobacteria	57723|Acidobacteria	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HFD2_k127_4991665_3	234267.Acid_7284	1.535e-77	264.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
HFD2_k127_4993141_1	497964.CfE428DRAFT_2531	9.16e-40	150.0	COG1216@1|root,COG4976@1|root,COG1216@2|Bacteria,COG4976@2|Bacteria,46W0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4993141_2	34506.g3068	2.181e-11	68.0	2D1ZE@1|root,2SJVP@2759|Eukaryota,3AI9D@33154|Opisthokonta,3BX0X@33208|Metazoa,3DEMU@33213|Bilateria	33208|Metazoa	S	LppC putative lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LppC
HFD2_k127_4993141_0	234267.Acid_4088	4.043e-203	664.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_4993141_3	639030.JHVA01000001_gene1285	2.561e-11	76.0	COG0497@1|root,COG0497@2|Bacteria,3Y6KC@57723|Acidobacteria,2JME0@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4997986_3	1396141.BATP01000047_gene3930	1.05e-56	203.0	COG3476@1|root,COG3476@2|Bacteria,46SXT@74201|Verrucomicrobia,2IVZD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	TspO/MBR family	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
HFD2_k127_4997986_2	391625.PPSIR1_26593	2.867e-62	225.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,42QZI@68525|delta/epsilon subdivisions,2WQXC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
HFD2_k127_4997986_0	1403819.BATR01000002_gene28	3.725e-137	450.0	COG1253@1|root,COG1253@2|Bacteria,46U7J@74201|Verrucomicrobia,2IVE3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HFD2_k127_4997986_1	452637.Oter_1438	3.698e-95	315.0	COG0861@1|root,COG0861@2|Bacteria,46TS9@74201|Verrucomicrobia,3K8X2@414999|Opitutae	414999|Opitutae	P	membrane	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HFD2_k127_5019559_2	1235797.C816_03475	3.034e-71	256.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes	1239|Firmicutes	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD2_k127_5019559_1	1009370.ALO_05033	1.606e-85	288.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,4H376@909932|Negativicutes	909932|Negativicutes	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD2_k127_5019559_0	1340493.JNIF01000003_gene4593	1.68e-160	537.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HFD2_k127_5019559_3	1424334.W822_22580	1.696e-22	103.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_5076826_3	247633.GP2143_17796	2.148e-98	335.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5076826_2	247633.GP2143_17791	1.295e-107	354.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5076826_1	234267.Acid_2447	2.275e-139	449.0	COG3391@1|root,COG3391@2|Bacteria,3Y8A0@57723|Acidobacteria	57723|Acidobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_5076826_0	861299.J421_1107	4.566e-158	509.0	COG3391@1|root,COG3391@2|Bacteria,1ZSNC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5090105_5	113395.AXAI01000010_gene2218	4.042e-07	59.0	28MSC@1|root,2ZB0S@2|Bacteria,1NG2A@1224|Proteobacteria,2U8EJ@28211|Alphaproteobacteria,3K390@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5090105_1	926554.KI912640_gene1366	8.593e-113	375.0	COG1960@1|root,COG1960@2|Bacteria,1WMGQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5090105_2	264198.Reut_B5103	1.572e-87	295.0	COG3145@1|root,COG3145@2|Bacteria,1N5HB@1224|Proteobacteria,2VHNU@28216|Betaproteobacteria,1K2E9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Alkylated DNA repair protein	alkB	-	1.14.11.33	ko:K03919	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	2OG-FeII_Oxy_2
HFD2_k127_5090105_7	111780.Sta7437_2407	0.0002745	52.0	2C65N@1|root,33D51@2|Bacteria,1G7N9@1117|Cyanobacteria,3VMYB@52604|Pleurocapsales	1117|Cyanobacteria	S	Agenet domain	-	-	-	-	-	-	-	-	-	-	-	-	Agenet
HFD2_k127_5090105_6	555793.WSK_0157	5.37e-05	52.0	293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,2U7U4@28211|Alphaproteobacteria,2K7J3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5090105_0	401053.AciPR4_0483	1.819e-116	386.0	COG4219@1|root,COG4219@2|Bacteria,3Y73G@57723|Acidobacteria,2JKMG@204432|Acidobacteriia	204432|Acidobacteriia	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738
HFD2_k127_5090105_4	1244869.H261_05754	5.706e-09	59.0	COG2161@1|root,COG2161@2|Bacteria,1NQFQ@1224|Proteobacteria,2USTR@28211|Alphaproteobacteria,2JY2T@204441|Rhodospirillales	204441|Rhodospirillales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_5090105_3	1392838.AWNM01000030_gene4397	3.906e-16	80.0	COG2388@1|root,COG2388@2|Bacteria,1PN9S@1224|Proteobacteria,2VYAX@28216|Betaproteobacteria,3T87K@506|Alcaligenaceae	28216|Betaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
HFD2_k127_5137155_1	1045855.DSC_03395	5.452e-156	506.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X3TV@135614|Xanthomonadales	135614|Xanthomonadales	M	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_5137155_3	234267.Acid_0809	8.869e-111	368.0	COG1940@1|root,COG1940@2|Bacteria,3Y4DD@57723|Acidobacteria	57723|Acidobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_5137155_4	1267535.KB906767_gene427	1.043e-87	293.0	2F161@1|root,33U75@2|Bacteria,3Y7M8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5137155_2	234267.Acid_0692	5.749e-142	456.0	COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria	57723|Acidobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_5137155_0	234267.Acid_0691	2.743e-161	514.0	COG0012@1|root,COG0012@2|Bacteria,3Y3D9@57723|Acidobacteria	57723|Acidobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD2_k127_5137155_5	1340493.JNIF01000003_gene4331	6.867e-71	248.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_5157130_4	926550.CLDAP_17520	7.389e-24	109.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_5157130_3	937777.Deipe_1199	2.952e-50	184.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HFD2_k127_5157130_2	479434.Sthe_0531	3.069e-122	403.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi,27Y45@189775|Thermomicrobia	2|Bacteria	C	Acyl- CoA dehydrogenase type 2 domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5157130_0	479434.Sthe_0530	2.845e-170	543.0	COG1960@1|root,COG1960@2|Bacteria,2G8AV@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.8	ko:K00255,ko:K11731	ko00071,ko00281,ko01100,ko01212,ko03320,map00071,map00281,map01100,map01212,map03320	M00087	R01279,R03777,R03857,R03990,R04751,R04754,R08089	RC00052,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5157130_1	479434.Sthe_0530	1.609e-155	500.0	COG1960@1|root,COG1960@2|Bacteria,2G8AV@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.8	ko:K00255,ko:K11731	ko00071,ko00281,ko01100,ko01212,ko03320,map00071,map00281,map01100,map01212,map03320	M00087	R01279,R03777,R03857,R03990,R04751,R04754,R08089	RC00052,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5157727_3	1267535.KB906767_gene4753	1.518e-77	289.0	COG0419@1|root,COG0515@1|root,COG0419@2|Bacteria,COG0515@2|Bacteria	2|Bacteria	KLT	protein kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13582,ko:K13924	ko02020,ko02030,ko04112,map02020,map02030,map04112	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_15,AAA_21,DUF4339,TMP_2,Tubulin_2
HFD2_k127_5157727_4	1340493.JNIF01000004_gene616	7.724e-58	212.0	COG4219@1|root,COG4219@2|Bacteria,3Y63E@57723|Acidobacteria	57723|Acidobacteria	KT	Protein of unknown function (DUF3738)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3738,Peptidase_M56
HFD2_k127_5157727_0	1267535.KB906767_gene3671	0.0	1163.0	COG1629@1|root,COG4771@2|Bacteria,3Y6A1@57723|Acidobacteria,2JKK3@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_5157727_1	1267535.KB906767_gene3672	5.591e-284	887.0	2E93F@1|root,333CD@2|Bacteria,3Y9CR@57723|Acidobacteria,2JP6M@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5157727_5	136993.KB900627_gene392	2.836e-42	169.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5157727_6	1340493.JNIF01000003_gene2122	2.09e-29	121.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5157727_2	234267.Acid_4912	5.81e-85	291.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,Peptidase_M56
HFD2_k127_5159608_12	187303.BN69_1725	5.471e-56	205.0	2EZCI@1|root,33SHV@2|Bacteria,1RACW@1224|Proteobacteria,2U5ZF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5159608_19	1173022.Cri9333_4175	4.721e-19	87.0	COG1724@1|root,COG1724@2|Bacteria,1G91K@1117|Cyanobacteria,1HDF1@1150|Oscillatoriales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_5159608_20	56107.Cylst_1294	2.076e-17	91.0	COG1598@1|root,COG1598@2|Bacteria,1G985@1117|Cyanobacteria,1HPV9@1161|Nostocales	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_5159608_9	234267.Acid_4343	1.575e-90	301.0	COG3548@1|root,COG3548@2|Bacteria,3Y607@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HFD2_k127_5159608_18	314225.ELI_11020	3.097e-20	98.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_5159608_14	234267.Acid_3551	6.773e-50	184.0	COG1309@1|root,COG1309@2|Bacteria,3Y4H4@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
HFD2_k127_5159608_4	234267.Acid_2760	1.082e-143	471.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria	57723|Acidobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HFD2_k127_5159608_10	1267535.KB906767_gene3366	1.265e-82	278.0	COG0066@1|root,COG0066@2|Bacteria,3Y39B@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD2_k127_5159608_0	1267535.KB906767_gene3365	1.499e-233	729.0	COG0065@1|root,COG0065@2|Bacteria,3Y2ID@57723|Acidobacteria,2JI0J@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_5159608_3	234267.Acid_4068	8.012e-159	511.0	COG0473@1|root,COG0473@2|Bacteria,3Y38Z@57723|Acidobacteria	57723|Acidobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_5159608_2	1267535.KB906767_gene3363	2.483e-184	592.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria,2JI0S@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_5159608_5	1267535.KB906767_gene3362	5.977e-135	434.0	COG0583@1|root,COG0583@2|Bacteria,3Y31P@57723|Acidobacteria,2JIC0@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5159608_16	521045.Kole_0020	3.189e-48	178.0	COG0698@1|root,COG0698@2|Bacteria,2GD08@200918|Thermotogae	200918|Thermotogae	G	ribose 5-phosphate isomerase B	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD2_k127_5159608_1	1267535.KB906767_gene3125	2.577e-205	646.0	COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria,2JI87@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_5159608_6	1340493.JNIF01000003_gene2991	1.045e-127	420.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_5159608_13	1340493.JNIF01000003_gene2990	7.476e-54	195.0	2FERC@1|root,346QE@2|Bacteria,3Y8RE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5159608_11	234267.Acid_6428	3.594e-57	205.0	COG0590@1|root,COG0590@2|Bacteria,3Y4KB@57723|Acidobacteria	57723|Acidobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	DUF3175,MafB19-deam
HFD2_k127_5159608_8	195253.Syn6312_3718	3.921e-92	313.0	COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria,1GYI4@1129|Synechococcus	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD2_k127_5159608_7	1267535.KB906767_gene3329	3.989e-99	333.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_5159608_15	1382359.JIAL01000001_gene2207	4.17e-49	181.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_5159608_21	1165096.ARWF01000001_gene1596	1.402e-16	88.0	COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria	1224|Proteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5171958_2	234267.Acid_0723	4.635e-148	474.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_5171958_5	234267.Acid_0724	2.559e-89	301.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD2_k127_5171958_1	234267.Acid_0726	3.303e-152	488.0	COG0303@1|root,COG0303@2|Bacteria,3Y6V2@57723|Acidobacteria	57723|Acidobacteria	H	'Molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5171958_6	1267535.KB906767_gene11	1.266e-33	130.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria	57723|Acidobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD2_k127_5171958_0	204669.Acid345_4506	1.274e-183	582.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria,2JIGI@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_5171958_3	1267533.KB906734_gene3885	2.626e-110	361.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_5171958_4	1267535.KB906767_gene14	4.178e-99	330.0	COG2025@1|root,COG2025@2|Bacteria,3Y3JE@57723|Acidobacteria,2JM9U@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_5185443_2	1380391.JIAS01000013_gene3446	1.498e-29	120.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD2_k127_5185443_0	94624.Bpet3499	3.778e-179	576.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VN65@28216|Betaproteobacteria,3T5RB@506|Alcaligenaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD2_k127_5185443_1	883080.HMPREF9697_01864	1.38e-56	205.0	COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2TT19@28211|Alphaproteobacteria,3JUK4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD2_k127_518833_1	234267.Acid_0253	3.414e-121	393.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	yxjG	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_518833_2	572477.Alvin_1965	3.147e-116	383.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_518833_6	700598.Niako_0942	2.882e-31	124.0	2C82G@1|root,32RK9@2|Bacteria,4NSXV@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD2_k127_518833_0	1267534.KB906756_gene662	6.136e-147	505.0	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,DUF4062,NB-ARC,TPR_12,TPR_19,TPR_8,Trans_reg_C
HFD2_k127_518833_5	1267535.KB906767_gene558	6.677e-76	288.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y78P@57723|Acidobacteria	57723|Acidobacteria	KLTU	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD2_k127_518833_4	710696.Intca_2186	2.205e-91	320.0	2BRPH@1|root,32KP4@2|Bacteria,2H2UK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_518833_3	1054213.HMPREF9946_00367	4.364e-101	335.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,2JS24@204441|Rhodospirillales	204441|Rhodospirillales	Q	Catechol dioxygenase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C,Dioxygenase_N
HFD2_k127_5191961_8	1267535.KB906767_gene249	2.441e-85	301.0	COG4783@1|root,COG4783@2|Bacteria,3Y7P0@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_5191961_3	1267535.KB906767_gene248	5.671e-145	479.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_5191961_4	1340493.JNIF01000004_gene942	1.213e-143	465.0	COG1820@1|root,COG1820@2|Bacteria,3Y3NQ@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_5191961_5	234267.Acid_1306	1.15e-134	472.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_5191961_1	234267.Acid_3725	3.757e-214	694.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_5191961_7	697282.Mettu_2234	2.317e-112	379.0	COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria,1SHXM@1236|Gammaproteobacteria,1XEX1@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5191961_2	1267535.KB906767_gene2636	3.297e-185	594.0	COG4805@1|root,COG4805@2|Bacteria,3Y468@57723|Acidobacteria,2JP3U@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD2_k127_5191961_0	1267535.KB906767_gene1575	1.507e-221	700.0	COG2133@1|root,COG2133@2|Bacteria,3Y6R6@57723|Acidobacteria,2JMHE@204432|Acidobacteriia	204432|Acidobacteriia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5191961_6	1267535.KB906767_gene1576	8.585e-126	417.0	COG2010@1|root,COG2010@2|Bacteria,3Y7CN@57723|Acidobacteria,2JK7I@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_5273043_2	1382359.JIAL01000001_gene2888	1.26e-65	228.0	COG2895@1|root,COG2895@2|Bacteria,3Y3AW@57723|Acidobacteria,2JHIJ@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
HFD2_k127_5273043_1	1267535.KB906767_gene1072	6.034e-151	485.0	COG0175@1|root,COG0175@2|Bacteria,3Y36I@57723|Acidobacteria,2JIQ5@204432|Acidobacteriia	204432|Acidobacteriia	EH	Phosphoadenosine phosphosulfate reductase family	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD2_k127_5273043_0	234267.Acid_1665	2.273e-304	940.0	COG0209@1|root,COG0209@2|Bacteria,3Y3Q1@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD2_k127_5315209_0	1267535.KB906767_gene2433	0.0	1283.0	COG0550@1|root,COG0550@2|Bacteria,3Y343@57723|Acidobacteria,2JHPW@204432|Acidobacteriia	204432|Acidobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HFD2_k127_5315209_3	234267.Acid_2400	3.329e-151	492.0	COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria	57723|Acidobacteria	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD2_k127_5315209_6	1340493.JNIF01000003_gene1957	2.656e-34	137.0	2DB97@1|root,32TX2@2|Bacteria,3Y59S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5315209_7	1340493.JNIF01000003_gene1958	3.235e-20	95.0	299QU@1|root,2ZWT2@2|Bacteria,3Y915@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5315209_2	234267.Acid_5863	5.865e-264	841.0	COG4386@1|root,COG4386@2|Bacteria,3Y76B@57723|Acidobacteria	57723|Acidobacteria	S	tail sheath protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5315209_4	234267.Acid_7868	4.132e-101	341.0	COG1230@1|root,COG1230@2|Bacteria,3Y32W@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HFD2_k127_5315209_5	1340493.JNIF01000003_gene1368	7.247e-44	162.0	COG3093@1|root,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HFD2_k127_5315209_1	234267.Acid_6445	1.006e-277	873.0	COG1615@1|root,COG1615@2|Bacteria,3Y6XA@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD2_k127_532231_2	234267.Acid_6299	2.798e-48	174.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD2_k127_532231_3	234267.Acid_3867	2.36e-40	152.0	COG4274@1|root,COG4274@2|Bacteria,3Y87J@57723|Acidobacteria	57723|Acidobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_532231_4	40571.JOEA01000014_gene1881	6.171e-28	117.0	COG1898@1|root,COG1898@2|Bacteria,2HA8V@201174|Actinobacteria	201174|Actinobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_532231_1	1087481.AGFX01000041_gene896	1.339e-62	220.0	COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,26XPE@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the metal hydrolase YfiT family	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_532231_0	1082931.KKY_2582	1.455e-116	383.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_532510_2	1267535.KB906767_gene1287	1.04e-172	558.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_532510_9	1267535.KB906767_gene3361	1.36e-58	219.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_532510_3	266117.Rxyl_1564	9.705e-169	538.0	COG0654@1|root,COG0654@2|Bacteria,2GM48@201174|Actinobacteria,4CPTA@84995|Rubrobacteria	84995|Rubrobacteria	CH	FAD binding domain	-	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD2_k127_532510_4	1267535.KB906767_gene3218	9.844e-155	496.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	57723|Acidobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	RecA
HFD2_k127_532510_11	234267.Acid_0043	3.704e-43	166.0	COG2834@1|root,COG2834@2|Bacteria,3Y4XE@57723|Acidobacteria	57723|Acidobacteria	M	outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HFD2_k127_532510_8	234267.Acid_2690	1.109e-73	261.0	COG3391@1|root,COG3391@2|Bacteria,3Y7IA@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_532510_1	234267.Acid_3811	4.21e-191	599.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria	57723|Acidobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD2_k127_532510_6	1340493.JNIF01000003_gene3680	7.181e-101	340.0	COG1792@1|root,COG1792@2|Bacteria,3Y3CK@57723|Acidobacteria	57723|Acidobacteria	M	Rod shape-determining protein MreC	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD2_k127_532510_10	234267.Acid_3813	1.153e-44	169.0	2CM1I@1|root,32SDF@2|Bacteria,3Y571@57723|Acidobacteria	57723|Acidobacteria	S	shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD2_k127_532510_0	1340493.JNIF01000003_gene3682	3.517e-218	693.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_532510_14	748280.NH8B_2372	2.76e-05	56.0	COG4655@1|root,COG4655@2|Bacteria,1R8E5@1224|Proteobacteria,2WGSJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD2_k127_532510_12	234267.Acid_6528	4.925e-19	93.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_532510_15	290340.AAur_2908	0.0005736	49.0	COG4961@1|root,COG4961@2|Bacteria,2GWMA@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_532510_5	1340493.JNIF01000003_gene3683	3.706e-137	445.0	COG0772@1|root,COG0772@2|Bacteria,3Y3DZ@57723|Acidobacteria	57723|Acidobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_532510_7	1286106.MPL1_06919	3.524e-99	355.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,45ZW6@72273|Thiotrichales	72273|Thiotrichales	J	ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD2_k127_532510_13	1089455.MOPEL_071_00510	1.207e-05	49.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria,4F7W1@85018|Dermatophilaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_5335417_3	1267535.KB906767_gene3058	1.282e-85	286.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria,2JHUJ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD2_k127_5335417_4	1267535.KB906767_gene3057	1.071e-35	142.0	COG0806@1|root,COG0806@2|Bacteria,3Y51G@57723|Acidobacteria	57723|Acidobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HFD2_k127_5335417_5	234267.Acid_2571	7.88e-33	128.0	COG1837@1|root,COG1837@2|Bacteria,3Y5N5@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HFD2_k127_5335417_6	1340493.JNIF01000003_gene3702	2.159e-29	120.0	COG0228@1|root,COG0228@2|Bacteria,3Y56G@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD2_k127_5335417_0	234267.Acid_2573	2.106e-222	697.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HFD2_k127_5335417_7	1463825.JNXC01000029_gene455	2.745e-13	82.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4E9UT@85010|Pseudonocardiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD2_k127_5335417_1	1267534.KB906754_gene3491	1.097e-217	717.0	COG1629@1|root,COG4771@2|Bacteria,3Y2M5@57723|Acidobacteria,2JMJB@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_5335417_2	1267535.KB906767_gene4753	8.838e-161	522.0	COG0419@1|root,COG0515@1|root,COG0419@2|Bacteria,COG0515@2|Bacteria	2|Bacteria	KLT	protein kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13582,ko:K13924	ko02020,ko02030,ko04112,map02020,map02030,map04112	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_15,AAA_21,DUF4339,TMP_2,Tubulin_2
HFD2_k127_5346105_0	1267535.KB906767_gene4470	0.0	1162.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria,2JIW0@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HFD2_k127_5346105_5	1340493.JNIF01000003_gene3584	5.787e-75	262.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_5346105_1	1340493.JNIF01000003_gene4593	1.866e-245	788.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HFD2_k127_5346105_4	1340493.JNIF01000004_gene309	3.056e-85	294.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_5346105_8	592029.DDD_1607	1.572e-16	89.0	COG2318@1|root,COG2318@2|Bacteria,4NRSP@976|Bacteroidetes,1I34C@117743|Flavobacteriia,3HKDS@363408|Nonlabens	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HFD2_k127_5346105_6	314271.RB2654_21003	3.135e-72	261.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	metal-dependent hydrolase of the TIM-barrel fold	ligI	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_5346105_3	627192.SLG_12120	3.189e-90	320.0	2ED7G@1|root,32HXH@2|Bacteria,1NR36@1224|Proteobacteria,2UQ2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_5346105_2	1340493.JNIF01000003_gene3330	1.398e-95	315.0	COG3865@1|root,COG3865@2|Bacteria,3Y4UB@57723|Acidobacteria	57723|Acidobacteria	H	3-demethylubiquinone-9 3-methyltransferase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	3-dmu-9_3-mt
HFD2_k127_5346105_7	234267.Acid_7637	5.738e-31	123.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_5375957_1	234267.Acid_1040	2.852e-63	219.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria	57723|Acidobacteria	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
HFD2_k127_5375957_0	1340493.JNIF01000003_gene2620	2.822e-120	394.0	COG1191@1|root,COG1191@2|Bacteria,3Y6IE@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HFD2_k127_5375957_2	1340493.JNIF01000003_gene3597	1.264e-31	125.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria	57723|Acidobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
HFD2_k127_5396939_0	1267535.KB906767_gene4165	1.541e-117	383.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria,2JIPK@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_5396939_2	234267.Acid_1115	3.629e-95	321.0	COG1189@1|root,COG1189@2|Bacteria,3Y3HM@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD2_k127_5396939_1	1267535.KB906767_gene30	6.26e-105	349.0	COG0061@1|root,COG0061@2|Bacteria,3Y3E6@57723|Acidobacteria,2JIH5@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD2_k127_5396939_3	1267534.KB906754_gene2565	2.136e-92	313.0	COG1301@1|root,COG1301@2|Bacteria,3Y2G6@57723|Acidobacteria,2JIP7@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K03309,ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23,2.A.23.1.1,2.A.23.1.2	-	-	SDF
HFD2_k127_5435817_1	234267.Acid_2122	1.831e-110	362.0	COG0524@1|root,COG0524@2|Bacteria,3Y6VV@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD2_k127_5435817_0	234267.Acid_2801	9.059e-134	440.0	COG3386@1|root,COG3386@2|Bacteria,3Y5XH@57723|Acidobacteria	2|Bacteria	G	SMP-30/Gluconolaconase/LRE-like region	MA20_02675	-	3.1.1.17	ko:K01053,ko:K13735	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05100,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map05100	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NHL,SGL
HFD2_k127_5435817_2	46429.BV95_04154	6.2e-48	176.0	COG1629@1|root,COG4771@2|Bacteria,1R4PY@1224|Proteobacteria,2U3FF@28211|Alphaproteobacteria,2K1WN@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_5448631_1	1267535.KB906767_gene541	3.52e-40	162.0	COG0671@1|root,COG0671@2|Bacteria,3Y6AR@57723|Acidobacteria,2JM7X@204432|Acidobacteriia	204432|Acidobacteriia	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HFD2_k127_5448631_2	234267.Acid_5858	6.655e-18	98.0	COG0500@1|root,COG0500@2|Bacteria,3Y94A@57723|Acidobacteria	57723|Acidobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5448631_0	1030157.AFMP01000008_gene3205	1.837e-102	342.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_5465492_3	234267.Acid_6216	2e-100	333.0	COG1212@1|root,COG1212@2|Bacteria,3Y4GZ@57723|Acidobacteria	57723|Acidobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HFD2_k127_5465492_1	1267535.KB906767_gene621	2.209e-292	904.0	COG0504@1|root,COG0504@2|Bacteria,3Y2MH@57723|Acidobacteria,2JID4@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD2_k127_5465492_2	1267535.KB906767_gene620	1.104e-111	367.0	COG2877@1|root,COG2877@2|Bacteria,3Y2WF@57723|Acidobacteria,2JI7M@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM DAHP synthetase I	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD2_k127_5465492_7	99598.Cal7507_2604	1.077e-05	47.0	COG1598@1|root,COG1598@2|Bacteria,1G9GK@1117|Cyanobacteria,1HPYF@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_5465492_4	1267535.KB906767_gene5280	3.068e-56	201.0	COG1329@1|root,COG1329@2|Bacteria,3Y4ZG@57723|Acidobacteria,2JMXA@204432|Acidobacteriia	204432|Acidobacteriia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HFD2_k127_5465492_0	1267535.KB906767_gene2620	0.0	1305.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria,2JIQ2@204432|Acidobacteriia	204432|Acidobacteriia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD2_k127_5465492_6	1340493.JNIF01000003_gene1539	1.007e-38	150.0	COG0597@1|root,COG0597@2|Bacteria,3Y55H@57723|Acidobacteria	57723|Acidobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD2_k127_5465492_5	234267.Acid_2363	6.588e-39	153.0	COG1309@1|root,COG1309@2|Bacteria,3Y8G6@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD2_k127_5469009_0	1340493.JNIF01000003_gene1300	8.317e-116	379.0	COG1073@1|root,COG1073@2|Bacteria,3Y99D@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
HFD2_k127_5469009_3	1267535.KB906767_gene1131	0.0006664	49.0	COG3087@1|root,COG3087@2|Bacteria,3Y4WI@57723|Acidobacteria	57723|Acidobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HFD2_k127_5469009_2	234267.Acid_0917	1.474e-28	116.0	COG1278@1|root,COG1278@2|Bacteria,3Y5NU@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_5469009_1	1082931.KKY_2582	3.318e-108	361.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_5487711_3	1267535.KB906767_gene700	3.134e-05	48.0	2EHAG@1|root,3394C@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5372)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5372
HFD2_k127_5487711_1	768671.ThimaDRAFT_4865	6.128e-91	306.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
HFD2_k127_5487711_0	1267535.KB906767_gene3700	9.308e-105	345.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HFD2_k127_5487711_4	1340493.JNIF01000003_gene4842	0.0005076	46.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3Y5S6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD2_k127_5510860_1	1267533.KB906738_gene2031	2.13e-141	453.0	COG1398@1|root,COG1398@2|Bacteria,3Y3F9@57723|Acidobacteria,2JHWH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_5510860_2	1382359.JIAL01000001_gene1417	6.487e-139	457.0	COG0531@1|root,COG0531@2|Bacteria,3Y4PR@57723|Acidobacteria,2JJPB@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HFD2_k127_5510860_0	639030.JHVA01000001_gene3907	9.066e-231	723.0	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
HFD2_k127_5510860_3	204669.Acid345_2701	6.193e-65	228.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_5533139_1	1123024.AUII01000038_gene4085	9.626e-54	201.0	COG1565@1|root,COG1565@2|Bacteria,2H31V@201174|Actinobacteria	201174|Actinobacteria	S	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD2_k127_5533139_0	864051.BurJ1DRAFT_2776	1.983e-127	421.0	COG2010@1|root,COG2010@2|Bacteria,1R1VN@1224|Proteobacteria,2WI66@28216|Betaproteobacteria,1KN79@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HFD2_k127_5533139_2	344747.PM8797T_00789	3.825e-05	55.0	COG1413@1|root,COG1413@2|Bacteria,2J0DE@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
HFD2_k127_554316_1	1267534.KB906759_gene1840	1.355e-15	80.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_554316_0	234267.Acid_4577	2.028e-169	548.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_554316_2	1224746.B932_3073	2.438e-15	83.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,2U7XA@28211|Alphaproteobacteria,2JU6J@204441|Rhodospirillales	204441|Rhodospirillales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_5577330_0	234267.Acid_7711	2.474e-161	515.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria	57723|Acidobacteria	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HFD2_k127_5577330_1	926566.Terro_0373	3.364e-42	163.0	COG1595@1|root,COG1595@2|Bacteria,3Y59D@57723|Acidobacteria,2JNBN@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5578595_0	1157708.KB907450_gene5904	2.112e-157	511.0	COG0666@1|root,COG0666@2|Bacteria,1P877@1224|Proteobacteria,2VJDT@28216|Betaproteobacteria,4AH4J@80864|Comamonadaceae	28216|Betaproteobacteria	S	ankyrin repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5578595_4	234267.Acid_0502	1.187e-36	145.0	28ZWN@1|root,2ZMM4@2|Bacteria,3Y8RZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5578595_1	497964.CfE428DRAFT_1847	2.299e-77	266.0	COG1028@1|root,COG1028@2|Bacteria	497964.CfE428DRAFT_1847|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5578595_3	1279017.AQYJ01000028_gene2525	8.336e-51	202.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5578595_8	589873.EP13_13630	0.0001406	55.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5578595_7	172088.AUGA01000021_gene5178	1.619e-05	56.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria,3JYA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35640	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HFD2_k127_5578595_2	756067.MicvaDRAFT_0493	1.108e-52	191.0	COG2202@1|root,COG2203@1|root,COG3452@1|root,COG4191@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3452@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,1G1Z8@1117|Cyanobacteria,1H950@1150|Oscillatoriales	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4
HFD2_k127_5578595_6	1408473.JHXO01000011_gene3168	4.154e-06	56.0	COG1680@1|root,COG1729@1|root,COG1680@2|Bacteria,COG1729@2|Bacteria,4NI1Z@976|Bacteroidetes,2FUDK@200643|Bacteroidia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HFD2_k127_5578595_5	555793.WSK_4047	5.482e-21	100.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5584598_7	1340493.JNIF01000004_gene1039	2.465e-38	146.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	COX3
HFD2_k127_5584598_9	1192034.CAP_2034	2.492e-14	81.0	2DR0H@1|root,339NS@2|Bacteria,1R3N7@1224|Proteobacteria,42X1P@68525|delta/epsilon subdivisions,2X8S7@28221|Deltaproteobacteria,2Z3NK@29|Myxococcales	28221|Deltaproteobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD2_k127_5584598_5	1267535.KB906767_gene1546	2.316e-52	194.0	COG3132@1|root,COG3132@2|Bacteria,3Y50M@57723|Acidobacteria,2JMSB@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HFD2_k127_5584598_1	234267.Acid_1177	1.309e-202	642.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HFD2_k127_5584598_8	234267.Acid_1416	1.153e-36	150.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C
HFD2_k127_5584598_4	1340493.JNIF01000004_gene801	3.509e-100	337.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD2_k127_5584598_10	561175.KB894093_gene4021	1.707e-10	74.0	2DQGK@1|root,336R1@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1266
HFD2_k127_5584598_3	234267.Acid_6502	1.314e-102	339.0	COG0149@1|root,COG0149@2|Bacteria,3Y2YS@57723|Acidobacteria	57723|Acidobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HFD2_k127_5584598_0	1340493.JNIF01000003_gene4090	0.0	1181.0	COG0860@1|root,COG3227@1|root,COG0860@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.4.24.28,3.5.1.28	ko:K01400,ko:K01417,ko:K01448,ko:K20274	ko01503,ko02024,map01503,map02024	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036	-	-	-	Amidase_3,Peptidase_M36
HFD2_k127_5584598_6	234267.Acid_6496	3.112e-43	164.0	2B707@1|root,3200P@2|Bacteria,3Y4XV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5584598_2	234267.Acid_6497	1.196e-122	407.0	COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,3Y3X5@57723|Acidobacteria	57723|Acidobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N,LpxK
HFD2_k127_5604059_6	330084.JNYZ01000001_gene3229	6.193e-21	99.0	2DB8V@1|root,2Z7SX@2|Bacteria,2IA72@201174|Actinobacteria,4E815@85010|Pseudonocardiales	201174|Actinobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD2_k127_5604059_2	330084.JNYZ01000001_gene3228	4.813e-129	432.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4E95H@85010|Pseudonocardiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3,NAD_binding_8
HFD2_k127_5604059_3	1267535.KB906767_gene5074	5.256e-75	254.0	COG2193@1|root,COG2193@2|Bacteria,3Y56Z@57723|Acidobacteria,2JMWM@204432|Acidobacteriia	204432|Acidobacteriia	C	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_5604059_4	1340493.JNIF01000004_gene1042	1.307e-60	223.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5604059_5	342113.DM82_1390	5.278e-36	139.0	COG2350@1|root,COG2350@2|Bacteria,1MZ8Y@1224|Proteobacteria,2W38Q@28216|Betaproteobacteria,1K9C8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HFD2_k127_5604059_1	1192034.CAP_9000	3.644e-146	475.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2X5FP@28221|Deltaproteobacteria,2YY48@29|Myxococcales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HFD2_k127_5604059_0	234267.Acid_5729	4.673e-148	479.0	COG0577@1|root,COG0577@2|Bacteria,3Y3HB@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5617954_0	1123060.JONP01000032_gene1846	5.385e-72	269.0	COG2267@1|root,COG2267@2|Bacteria,1QVG0@1224|Proteobacteria,2TS32@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_5617954_2	269482.Bcep1808_6278	6.932e-34	151.0	COG2267@1|root,COG2267@2|Bacteria,1QVG0@1224|Proteobacteria,2W2PW@28216|Betaproteobacteria,1KH3M@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_5617954_11	1096546.WYO_5607	1.68e-05	47.0	COG2267@1|root,COG2267@2|Bacteria,1QVG0@1224|Proteobacteria,2TS32@28211|Alphaproteobacteria,1JU0X@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_5617954_6	1267535.KB906767_gene179	7.637e-17	82.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5617954_8	397290.C810_02472	1.493e-12	70.0	COG1724@1|root,COG1724@2|Bacteria,1UF0Q@1239|Firmicutes,25K13@186801|Clostridia,27PUZ@186928|unclassified Lachnospiraceae	186801|Clostridia	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_5617954_7	604331.AUHY01000095_gene624	6.783e-15	81.0	2CBAE@1|root,32YK1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5617954_4	1082931.KKY_123	5.301e-27	122.0	2CBAE@1|root,3343U@2|Bacteria,1Q6VU@1224|Proteobacteria,2UJ1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5617954_5	391612.CY0110_28224	4.633e-17	92.0	2DBIE@1|root,32TXH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5617954_9	555793.WSK_3229	1.353e-07	59.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5617954_1	314260.PB2503_01362	5.368e-42	169.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5617954_10	715451.ambt_12010	5.085e-06	57.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5622025_5	1331060.RLDS_02925	2.683e-30	123.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,2K6RP@204457|Sphingomonadales	204457|Sphingomonadales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_5622025_3	1267535.KB906767_gene4077	6.95e-171	546.0	COG2239@1|root,COG2239@2|Bacteria,3Y3WD@57723|Acidobacteria,2JI0X@204432|Acidobacteriia	204432|Acidobacteriia	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
HFD2_k127_5622025_1	234267.Acid_6728	2.826e-195	616.0	COG1914@1|root,COG1914@2|Bacteria,3Y3EU@57723|Acidobacteria	57723|Acidobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD2_k127_5622025_4	240015.ACP_1661	1.019e-49	187.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria,2JIII@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_5622025_6	269796.Rru_A1473	4.002e-28	122.0	2CIU6@1|root,32S8H@2|Bacteria,1MZTN@1224|Proteobacteria,2UCA8@28211|Alphaproteobacteria,2JUA3@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5622025_2	861299.J421_3345	1.612e-180	575.0	COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HFD2_k127_5622025_0	1267535.KB906767_gene3470	1.052e-205	659.0	COG1960@1|root,COG1960@2|Bacteria,3Y2NA@57723|Acidobacteria,2JII2@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5622025_7	234267.Acid_1212	3.346e-26	119.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03770,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_5625853_0	234267.Acid_4148	4.628e-317	977.0	COG0488@1|root,COG0488@2|Bacteria,3Y340@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD2_k127_5625853_3	1267535.KB906767_gene5467	3.036e-75	254.0	COG1403@1|root,COG1403@2|Bacteria,3Y500@57723|Acidobacteria	57723|Acidobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HFD2_k127_5625853_2	1198114.AciX9_3521	2.636e-88	306.0	COG1309@1|root,COG1309@2|Bacteria,3Y7ND@57723|Acidobacteria,2JNV9@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_5625853_1	450851.PHZ_c0726	2.514e-128	419.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,2KIAB@204458|Caulobacterales	204458|Caulobacterales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HFD2_k127_5665696_1	1267535.KB906767_gene2252	2.647e-175	557.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria	57723|Acidobacteria	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_5665696_0	1267535.KB906767_gene2248	3.633e-222	695.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_5688163_0	234267.Acid_1521	9.12e-101	341.0	2EXCM@1|root,33QP8@2|Bacteria,3Y730@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5688163_1	234267.Acid_1804	7.903e-71	246.0	COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria	57723|Acidobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD2_k127_5688163_3	234267.Acid_1805	3.963e-48	181.0	COG0457@1|root,COG0457@2|Bacteria,3Y5WJ@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5688163_2	234267.Acid_1806	1.119e-54	199.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_5696097_0	1385517.N800_08900	1.011e-175	556.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,1RZZ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5696097_11	1123508.JH636440_gene2808	5.382e-40	165.0	COG1835@1|root,COG2148@1|root,COG1835@2|Bacteria,COG2148@2|Bacteria,2IZIX@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Bac_transf
HFD2_k127_5696097_1	234267.Acid_1908	1.904e-147	474.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3Y339@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD2_k127_5696097_6	234267.Acid_2007	2.499e-91	312.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HFD2_k127_5696097_7	247490.KSU1_C0355	5.293e-77	270.0	COG1322@1|root,COG1322@2|Bacteria,2J2TY@203682|Planctomycetes	203682|Planctomycetes	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD2_k127_5696097_3	234267.Acid_2269	1.1e-124	431.0	COG3391@1|root,COG5555@1|root,COG3391@2|Bacteria,COG5555@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Metallophos
HFD2_k127_5696097_2	1267535.KB906767_gene3950	3.747e-138	452.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria,2JMAT@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5696097_4	234267.Acid_7240	1.784e-120	396.0	COG0542@1|root,COG2204@1|root,COG0542@2|Bacteria,COG2204@2|Bacteria,3Y6T8@57723|Acidobacteria	57723|Acidobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small,Response_reg
HFD2_k127_5696097_12	1267535.KB906767_gene689	1.862e-36	140.0	COG0361@1|root,COG0361@2|Bacteria,3Y8IP@57723|Acidobacteria	57723|Acidobacteria	J	Translation initiation factor 1A / IF-1	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD2_k127_5696097_8	234267.Acid_6464	1.774e-74	264.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_6464|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5696097_10	1267535.KB906767_gene1058	2.1e-53	195.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HFD2_k127_5696097_9	1340493.JNIF01000004_gene502	3.573e-72	254.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5696097_5	1267535.KB906767_gene316	4.194e-110	368.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD2_k127_5731833_2	1163409.UUA_04853	4.517e-61	222.0	2C312@1|root,2Z7N1@2|Bacteria,1R9N9@1224|Proteobacteria,1S1HP@1236|Gammaproteobacteria,1X7YE@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5731833_3	909663.KI867150_gene69	7.218e-56	203.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5731833_4	357808.RoseRS_0607	8.973e-47	176.0	COG2010@1|root,COG2010@2|Bacteria,2G6R3@200795|Chloroflexi,377DZ@32061|Chloroflexia	32061|Chloroflexia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HFD2_k127_5731833_1	156889.Mmc1_2864	7.171e-131	426.0	COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
HFD2_k127_5731833_5	1173024.KI912153_gene170	3.458e-23	108.0	COG3464@1|root,COG3464@2|Bacteria,1G1W2@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
HFD2_k127_5731833_6	1267535.KB906767_gene3646	1.447e-20	102.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria,2JK3G@204432|Acidobacteriia	204432|Acidobacteriia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
HFD2_k127_5731833_0	234267.Acid_0024	2.879e-184	607.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_5731833_9	1267535.KB906767_gene4277	0.0002609	48.0	COG0789@1|root,COG0789@2|Bacteria,3Y5EZ@57723|Acidobacteria,2JN9T@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_5731833_7	1340493.JNIF01000003_gene2529	1.611e-09	61.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_5743401_4	926569.ANT_20150	3.538e-58	214.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_5743401_2	572477.Alvin_1799	6.944e-120	392.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXRF@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
HFD2_k127_5743401_1	234267.Acid_1587	1.579e-153	494.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria	57723|Acidobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD2_k127_5743401_5	1283300.ATXB01000001_gene377	8.649e-30	125.0	2EFPP@1|root,339FP@2|Bacteria,1NA60@1224|Proteobacteria,1SH3I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HFD2_k127_5743401_3	1267535.KB906767_gene493	9.803e-61	214.0	COG0454@1|root,COG0454@2|Bacteria,3Y9FN@57723|Acidobacteria	57723|Acidobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_5743401_0	1267535.KB906767_gene4673	0.0	1048.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria,2JIA9@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD2_k127_5773192_1	1410620.SHLA_2c001080	3.534e-17	87.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2TUFY@28211|Alphaproteobacteria,4BBM6@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HFD2_k127_5773192_0	192952.MM_0503	1.569e-40	165.0	COG1266@1|root,arCOG02768@2157|Archaea,2XYFG@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_5773192_2	1123023.JIAI01000001_gene6777	2.03e-16	82.0	COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria	201174|Actinobacteria	CO	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5780785_9	1123261.AXDW01000004_gene2722	2.964e-59	210.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S427@1236|Gammaproteobacteria,1XCFN@135614|Xanthomonadales	135614|Xanthomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K22479	-	-	-	-	ko00000	-	-	-	Acetyltransf_3
HFD2_k127_5780785_3	1340493.JNIF01000003_gene1994	1.71e-116	381.0	COG0412@1|root,COG0412@2|Bacteria,3Y4GC@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_5780785_8	1340493.JNIF01000003_gene3101	9.535e-62	227.0	COG0392@1|root,COG0392@2|Bacteria,3Y7S6@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HFD2_k127_5780785_4	1267535.KB906767_gene2582	1.597e-110	368.0	COG0438@1|root,COG0438@2|Bacteria,3Y68S@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_5780785_13	667632.KB890171_gene3523	1.126e-13	81.0	COG0784@1|root,COG4585@1|root,COG0784@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,1K6K8@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE,HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_5780785_2	1340493.JNIF01000003_gene2468	1.013e-131	429.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria	57723|Acidobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_5780785_10	234267.Acid_7407	4.375e-51	196.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,3Y4FC@57723|Acidobacteria	57723|Acidobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD2_k127_5780785_1	1267535.KB906767_gene4080	1.285e-152	485.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria,2JHXA@204432|Acidobacteriia	204432|Acidobacteriia	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_5780785_11	1267535.KB906767_gene3605	1.493e-40	154.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria	57723|Acidobacteria	K	regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_5780785_6	1267535.KB906767_gene2773	5.944e-96	320.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria,2JII0@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_5780785_12	234267.Acid_1397	1.316e-28	117.0	2DF3Q@1|root,2ZQCR@2|Bacteria,3Y8YJ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5780785_0	234267.Acid_2823	0.0	1032.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_5780785_7	234267.Acid_0953	5.666e-71	251.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria	57723|Acidobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD2_k127_5780785_5	234267.Acid_0954	1.118e-99	338.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_5802068_2	234267.Acid_1401	5.064e-56	205.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_5802068_3	1267535.KB906767_gene4421	2.128e-23	104.0	2EN0M@1|root,33FNU@2|Bacteria,3Y60X@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5802068_1	234267.Acid_6703	4.13e-105	344.0	COG0176@1|root,COG0176@2|Bacteria,3Y4BN@57723|Acidobacteria	57723|Acidobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_5802068_0	1267535.KB906767_gene2972	5.749e-242	767.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HFD2_k127_5848203_0	1267535.KB906767_gene42	6.755e-43	170.0	28MCN@1|root,2ZAQR@2|Bacteria,3Y8K1@57723|Acidobacteria,2JNFU@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5848203_1	1123060.JONP01000002_gene1013	3.284e-05	48.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TT4X@28211|Alphaproteobacteria,2JZTG@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_5850218_8	1499967.BAYZ01000170_gene5515	2.832e-19	89.0	COG2929@1|root,COG2929@2|Bacteria,2NS3F@2323|unclassified Bacteria	2|Bacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HFD2_k127_5850218_7	1499967.BAYZ01000170_gene5514	1.958e-22	98.0	2C6B2@1|root,335GA@2|Bacteria,2NRFZ@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5850218_0	1267535.KB906767_gene2623	5.029e-173	560.0	COG0616@1|root,COG0616@2|Bacteria,3Y3M1@57723|Acidobacteria	57723|Acidobacteria	OU	PFAM peptidase S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD2_k127_5850218_3	1340493.JNIF01000003_gene2288	9.308e-43	163.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_5850218_1	234267.Acid_1863	4.14e-153	491.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria	57723|Acidobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HFD2_k127_5850218_5	234267.Acid_1246	3.233e-33	132.0	2DMID@1|root,32RSF@2|Bacteria,3Y82Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5850218_6	1123054.KB907716_gene171	8.381e-28	113.0	COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,1S90V@1236|Gammaproteobacteria,1WZFH@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_5850218_4	1479235.KK366039_gene920	2.082e-34	133.0	COG4115@1|root,COG4115@2|Bacteria,1N0WH@1224|Proteobacteria,1S8ZF@1236|Gammaproteobacteria,1XPT0@135619|Oceanospirillales	135619|Oceanospirillales	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
HFD2_k127_5850218_2	1267535.KB906767_gene3485	3.351e-51	185.0	COG1211@1|root,COG1211@2|Bacteria,3Y3VR@57723|Acidobacteria,2JI25@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD2_k127_5921550_3	204773.HEAR3326	5.004e-19	89.0	COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2VKMA@28216|Betaproteobacteria,473SN@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD2_k127_5921550_1	1096546.WYO_3808	2.239e-109	363.0	COG1116@1|root,COG1116@2|Bacteria,1MUYG@1224|Proteobacteria,2TVQX@28211|Alphaproteobacteria,1JT6A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_5921550_0	1217720.ALOX01000032_gene285	2.935e-116	382.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2TV2Y@28211|Alphaproteobacteria,2JVC6@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD2_k127_5921550_2	1340493.JNIF01000003_gene2519	4.007e-25	117.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_595042_5	234267.Acid_6397	4.37e-110	365.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
HFD2_k127_595042_3	1267535.KB906767_gene1733	1.108e-165	527.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria,2JIN8@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HFD2_k127_595042_7	1267535.KB906767_gene1734	3.058e-44	171.0	COG0666@1|root,COG0666@2|Bacteria,3Y86V@57723|Acidobacteria	57723|Acidobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3
HFD2_k127_595042_6	1267535.KB906767_gene1735	1.08e-50	184.0	2BXJ8@1|root,342E7@2|Bacteria,3Y87K@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_595042_2	1340493.JNIF01000003_gene1734	3.787e-198	625.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria	57723|Acidobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD2_k127_595042_1	234267.Acid_7184	5.167e-212	682.0	COG1044@1|root,COG1044@2|Bacteria,3Y2ZS@57723|Acidobacteria	57723|Acidobacteria	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HFD2_k127_595042_0	234267.Acid_7185	6.81e-223	712.0	COG3386@1|root,COG3386@2|Bacteria,3Y2G7@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_595042_4	234267.Acid_2751	3.486e-129	420.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,3Y4K4@57723|Acidobacteria	57723|Acidobacteria	P	TrkA-C domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HFD2_k127_595042_8	234267.Acid_2158	2.354e-08	57.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_5977504_2	1267535.KB906767_gene5300	1.921e-152	490.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_5977504_4	97096.XP_007790920.1	1.849e-114	388.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_5977504_7	639030.JHVA01000001_gene1218	9.917e-36	141.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD2_k127_5977504_6	1267535.KB906767_gene4358	3.665e-37	147.0	COG2318@1|root,COG2318@2|Bacteria,3Y4TP@57723|Acidobacteria,2JJPR@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_5977504_5	1267535.KB906767_gene5233	3.823e-61	222.0	COG2823@1|root,COG2823@2|Bacteria,3Y7GR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5977504_0	234267.Acid_3075	3.404e-213	673.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD2_k127_5977504_3	64471.sync_2679	1.006e-143	472.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1GZCX@1129|Synechococcus	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_5977504_1	1265313.HRUBRA_01849	6.144e-172	562.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ_2
HFD2_k127_5988824_1	215803.DB30_1747	1.406e-30	139.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	MA20_04930	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD2_k127_5988824_0	443255.SCLAV_p1151	4.953e-76	263.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_600279_2	984262.SGRA_3731	8.767e-28	115.0	COG0502@1|root,COG0502@2|Bacteria,4NEMA@976|Bacteroidetes,1IPD7@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HFD2_k127_600279_0	234267.Acid_4906	4.139e-162	520.0	COG3667@1|root,COG3667@2|Bacteria,3Y3FP@57723|Acidobacteria	57723|Acidobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_600279_3	234267.Acid_4750	3.625e-27	116.0	COG1917@1|root,COG1917@2|Bacteria,3Y5JM@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_600279_1	234267.Acid_6772	1.661e-79	271.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_6009370_6	234267.Acid_4515	1.244e-43	164.0	COG1131@1|root,COG1131@2|Bacteria,3Y6FZ@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6009370_4	1382359.JIAL01000001_gene1268	9.037e-97	324.0	COG1277@1|root,COG1277@2|Bacteria,3Y6D0@57723|Acidobacteria	57723|Acidobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD2_k127_6009370_2	234267.Acid_4517	2.965e-122	413.0	COG3225@1|root,COG3225@2|Bacteria,3Y6WR@57723|Acidobacteria	57723|Acidobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HFD2_k127_6009370_3	234267.Acid_4518	8.204e-121	402.0	2ANCT@1|root,31DBC@2|Bacteria,3Y69A@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HFD2_k127_6009370_0	234267.Acid_4519	1.824e-157	509.0	COG1488@1|root,COG1488@2|Bacteria,3Y6U3@57723|Acidobacteria	57723|Acidobacteria	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HFD2_k127_6009370_5	234267.Acid_4520	4.965e-60	213.0	COG1335@1|root,COG1335@2|Bacteria,3Y7ZP@57723|Acidobacteria	57723|Acidobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD2_k127_6009370_1	234267.Acid_2848	1.469e-123	405.0	COG1044@1|root,COG1044@2|Bacteria,3Y6ZT@57723|Acidobacteria	57723|Acidobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD2_k127_6009370_7	1340493.JNIF01000003_gene2637	4.117e-14	79.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,TonB_C
HFD2_k127_6014833_0	1340493.JNIF01000003_gene3300	1.595e-272	871.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6014833_7	1340493.JNIF01000003_gene3299	4.2e-125	411.0	COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria	57723|Acidobacteria	NU	type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_6014833_8	1340493.JNIF01000003_gene3298	3.161e-103	344.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_6014833_1	1340493.JNIF01000003_gene3297	4.218e-248	770.0	COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria	57723|Acidobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD2_k127_6014833_5	1340493.JNIF01000003_gene3296	1.344e-129	425.0	COG4963@1|root,COG4963@2|Bacteria,3Y44H@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD2_k127_6014833_3	1340493.JNIF01000003_gene3295	5.529e-158	510.0	COG4964@1|root,COG4964@2|Bacteria,3Y3DF@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD2_k127_6014833_9	1340493.JNIF01000003_gene3294	6.943e-96	322.0	COG3745@1|root,COG3745@2|Bacteria,3Y4HR@57723|Acidobacteria	57723|Acidobacteria	U	PFAM SAF domain	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_6014833_12	1340493.JNIF01000003_gene3293	2.557e-33	139.0	COG1989@1|root,COG1989@2|Bacteria,3Y9FS@57723|Acidobacteria	57723|Acidobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HFD2_k127_6014833_4	1340493.JNIF01000003_gene3292	1.003e-129	437.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria	57723|Acidobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6014833_16	1197906.CAJQ02000047_gene4098	3.321e-08	65.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,3JT48@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HFD2_k127_6014833_11	1340493.JNIF01000003_gene3291	2.939e-59	213.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_6014833_6	1267535.KB906767_gene4493	9.483e-126	415.0	COG0477@1|root,COG2814@2|Bacteria,3Y4T2@57723|Acidobacteria,2JKF4@204432|Acidobacteriia	204432|Acidobacteriia	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6014833_2	234267.Acid_5378	7.539e-209	656.0	COG0436@1|root,COG0436@2|Bacteria,3Y6EJ@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_6014833_15	414684.RC1_3075	2.728e-25	108.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2UFXF@28211|Alphaproteobacteria,2JU2Z@204441|Rhodospirillales	204441|Rhodospirillales	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD2_k127_6014833_13	883.DvMF_1668	7.956e-27	111.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,42VG7@68525|delta/epsilon subdivisions,2WRNJ@28221|Deltaproteobacteria,2MG0A@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HFD2_k127_6014833_10	234267.Acid_0376	1.741e-92	313.0	COG0454@1|root,COG0456@2|Bacteria,3Y3VJ@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_6014833_14	1267535.KB906767_gene1747	2.397e-25	106.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_6037955_6	469371.Tbis_3333	1.399e-14	79.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4E8JG@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_6037955_3	234267.Acid_1881	2.918e-124	406.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6037955_4	234267.Acid_1882	1.501e-77	276.0	2DF1J@1|root,2ZQ4G@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD2_k127_6037955_5	1346791.M529_07235	2.065e-67	240.0	COG1917@1|root,COG1917@2|Bacteria,1NTJ5@1224|Proteobacteria,2UP17@28211|Alphaproteobacteria,2K9RX@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_6037955_0	234267.Acid_3929	3.354e-168	545.0	COG0405@1|root,COG0405@2|Bacteria,3Y2I7@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_6037955_1	1267535.KB906767_gene941	1.681e-140	468.0	COG3391@1|root,COG3391@2|Bacteria,3Y2QH@57723|Acidobacteria	57723|Acidobacteria	M	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HFD2_k127_6037955_2	1267535.KB906767_gene4360	2.062e-124	406.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria,2JM7G@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HFD2_k127_6075039_1	221288.JH992900_gene264	1.206e-66	231.0	COG1028@1|root,COG1028@2|Bacteria,1G0IE@1117|Cyanobacteria,1JJM1@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD2_k127_6075039_3	204669.Acid345_3217	8.271e-13	77.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	MtrB_PioB,OMP_b-brl
HFD2_k127_6075039_0	251221.35211731	2.409e-163	521.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HFD2_k127_6075039_2	583355.Caka_1928	9.566e-41	162.0	COG0189@1|root,COG0586@1|root,COG1073@1|root,COG0189@2|Bacteria,COG0586@2|Bacteria,COG1073@2|Bacteria,46UXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	HJ	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_6077141_5	234267.Acid_5840	1.312e-32	129.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_6077141_3	234267.Acid_0131	7.164e-78	278.0	COG3103@1|root,COG3103@2|Bacteria,3Y3S0@57723|Acidobacteria	57723|Acidobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_8
HFD2_k127_6077141_1	1340493.JNIF01000003_gene2604	2.737e-126	420.0	COG2755@1|root,COG2755@2|Bacteria,3Y7DX@57723|Acidobacteria	57723|Acidobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_6077141_2	1340493.JNIF01000003_gene2736	2.161e-121	415.0	COG2755@1|root,COG2755@2|Bacteria,3Y7PE@57723|Acidobacteria	57723|Acidobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_6077141_0	1340493.JNIF01000003_gene2737	5.699e-165	529.0	COG1696@1|root,COG1696@2|Bacteria,3Y4ZP@57723|Acidobacteria	57723|Acidobacteria	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HFD2_k127_6077141_4	234267.Acid_7637	6.101e-76	257.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_6095977_0	42256.RradSPS_2906	2.066e-43	169.0	COG2898@1|root,COG2898@2|Bacteria,2I2ZR@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised conserved protein (DUF2156)	lysX	-	2.3.2.3,6.1.1.6	ko:K04567,ko:K14205	ko00970,ko01503,ko02020,ko05150,map00970,map01503,map02020,map05150	M00359,M00360,M00726	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko01504,ko03016	2.A.1.3.37	-	-	DUF2156,tRNA-synt_2_TM
HFD2_k127_6095977_1	234267.Acid_6462	3.626e-07	54.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4
HFD2_k127_6115063_4	234267.Acid_3096	3.138e-67	237.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_6115063_7	335543.Sfum_1483	4.354e-33	134.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MRYE@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD2_k127_6115063_0	977880.RALTA_A1375	2.414e-181	578.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHD2@28216|Betaproteobacteria,1K0HV@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	TIGRFAM metabolite H symporter, major facilitator superfamily (MFS)	citA	-	-	ko:K03288	-	-	-	-	ko00000,ko02000	2.A.1.6.1,2.A.1.6.7	-	-	MFS_1,Sugar_tr
HFD2_k127_6115063_8	309807.SRU_0793	4.43e-16	87.0	COG3595@1|root,COG3595@2|Bacteria,4PFA3@976|Bacteroidetes,1FKCN@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
HFD2_k127_6115063_6	1267535.KB906767_gene4696	9.015e-50	185.0	COG2020@1|root,COG2020@2|Bacteria,3Y55R@57723|Acidobacteria,2JJVJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
HFD2_k127_6115063_5	555793.WSK_3235	2.535e-60	219.0	2EVK9@1|root,33P0C@2|Bacteria,1P9RH@1224|Proteobacteria,2UVJR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6115063_2	75379.Tint_1847	8.467e-92	316.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2VH6H@28216|Betaproteobacteria,1KK4Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glucose sorbosone	yliI	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
HFD2_k127_6115063_3	886293.Sinac_1155	4.46e-74	266.0	COG0666@1|root,COG0666@2|Bacteria,2J1F8@203682|Planctomycetes	203682|Planctomycetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD2_k127_6115063_1	886293.Sinac_1154	9.115e-96	321.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_6142316_4	926566.Terro_0027	1.072e-27	118.0	COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria,2JID7@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_6142316_1	234267.Acid_7127	8.891e-123	397.0	COG1691@1|root,COG1691@2|Bacteria,3Y3BX@57723|Acidobacteria	57723|Acidobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD2_k127_6142316_3	261292.Nit79A3_0712	7.105e-53	191.0	COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,371YP@32003|Nitrosomonadales	28216|Betaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,STN,TonB_dep_Rec
HFD2_k127_6152173_1	1340493.JNIF01000003_gene1440	6.253e-114	384.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Chondroitinas_B
HFD2_k127_6152173_3	234267.Acid_7512	1.647e-102	348.0	COG1538@1|root,COG1538@2|Bacteria,3Y54R@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_6152173_2	234267.Acid_7513	3.978e-109	368.0	COG0845@1|root,COG0845@2|Bacteria,3Y49U@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23,YtkA
HFD2_k127_6152173_0	335543.Sfum_2246	0.0	1494.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
HFD2_k127_6152173_4	1082931.KKY_2582	8.063e-33	132.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_615701_2	234267.Acid_6361	5.583e-27	115.0	COG4818@1|root,COG4818@2|Bacteria,3Y5MZ@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870,zinc_ribbon_2
HFD2_k127_615701_0	234267.Acid_6362	4.81e-97	327.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,SH3_3
HFD2_k127_615701_3	234267.Acid_6366	1.412e-25	113.0	2FHZB@1|root,349S8@2|Bacteria,3Y8KS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_615701_1	1340493.JNIF01000003_gene2857	1.097e-53	199.0	COG4254@1|root,COG4254@2|Bacteria,3Y90P@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_6160006_3	452637.Oter_0623	1.003e-40	153.0	COG3428@1|root,COG3428@2|Bacteria,46VXR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
HFD2_k127_6160006_0	1268068.PG5_65010	2.222e-163	535.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	exaA	-	1.1.2.8,1.1.5.5,1.1.9.1	ko:K00114,ko:K17760,ko:K22473	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285,R09479	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_6160006_1	1267533.KB906735_gene4583	1.498e-101	335.0	COG2041@1|root,COG2041@2|Bacteria,3Y3AI@57723|Acidobacteria,2JHW2@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD2_k127_6160006_2	204669.Acid345_3942	4.724e-89	300.0	COG4117@1|root,COG4117@2|Bacteria,3Y4KG@57723|Acidobacteria,2JJC0@204432|Acidobacteriia	204432|Acidobacteriia	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD2_k127_6160006_4	1236959.BAMT01000015_gene2850	1.927e-26	118.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2W82N@28216|Betaproteobacteria,2KNHR@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6160006_5	555793.WSK_2321	1.569e-18	91.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria,2UHWX@28211|Alphaproteobacteria,2KBI7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6161765_4	1165096.ARWF01000001_gene430	5.303e-09	58.0	2BUP9@1|root,32Q08@2|Bacteria,1PJNM@1224|Proteobacteria,2W82A@28216|Betaproteobacteria,2KNEM@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6161765_1	1340493.JNIF01000003_gene2122	3.21e-19	93.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6161765_0	1340493.JNIF01000003_gene2427	2.276e-150	490.0	COG3182@1|root,COG3182@2|Bacteria	2|Bacteria	E	Iron-regulated membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HFD2_k127_6161765_2	1221522.B723_12610	2.527e-14	78.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,1RVTE@1236|Gammaproteobacteria,1YUCY@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6161765_5	690585.JNNU01000011_gene2820	1.715e-08	64.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,2UDGH@28211|Alphaproteobacteria,4BF3A@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6161765_3	309807.SRU_2368	3.214e-14	81.0	COG1612@1|root,COG1612@2|Bacteria,4PEIM@976|Bacteroidetes,1FJ6F@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HFD2_k127_6162458_5	555793.WSK_4047	8.955e-23	111.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6162458_7	715451.ambt_12010	1.093e-07	63.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6162458_1	414996.IL38_11625	1.529e-115	383.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4084I@622450|Actinopolysporales	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE2	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_6162458_3	234267.Acid_7424	8.578e-49	177.0	COG0607@1|root,COG0607@2|Bacteria,3Y5RG@57723|Acidobacteria	57723|Acidobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_6162458_0	234267.Acid_7425	2.715e-191	604.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria	57723|Acidobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HFD2_k127_6162458_2	1267535.KB906767_gene2107	1.124e-95	323.0	COG2103@1|root,COG2103@2|Bacteria,3Y378@57723|Acidobacteria,2JHNG@204432|Acidobacteriia	204432|Acidobacteriia	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS_2
HFD2_k127_6164529_0	1267535.KB906767_gene2916	8.414e-196	617.0	COG0277@1|root,COG0277@2|Bacteria,3Y36Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HFD2_k127_6164529_2	1340493.JNIF01000003_gene3859	3.78e-87	296.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_6164529_1	1267535.KB906767_gene5132	3.836e-116	389.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_6164568_7	1297865.APJD01000009_gene2739	1.078e-06	59.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3JSFY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PQQ-like domain	MA20_34345	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_6164568_5	926560.KE387023_gene1528	8.271e-13	77.0	COG2010@1|root,COG2010@2|Bacteria,1WN9N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_6164568_8	562970.Btus_3037	1.984e-06	53.0	28W7I@1|root,2ZI85@2|Bacteria,1W3V1@1239|Firmicutes,4I13M@91061|Bacilli,27AJJ@186823|Alicyclobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6164568_6	460265.Mnod_0603	1.873e-08	58.0	COG2026@1|root,COG2026@2|Bacteria,1N7BE@1224|Proteobacteria,2UM88@28211|Alphaproteobacteria,1JW8R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	DJ	Plasmid stabilization	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HFD2_k127_6164568_2	1267535.KB906767_gene2409	1.569e-114	381.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria,2JI45@204432|Acidobacteriia	204432|Acidobacteriia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HFD2_k127_6164568_1	234267.Acid_3432	3.056e-176	568.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
HFD2_k127_6164568_4	1267535.KB906767_gene4335	1.635e-97	325.0	2F1JK@1|root,33UK0@2|Bacteria,3Y7KY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6164568_0	234267.Acid_4105	4.899e-252	793.0	COG0367@1|root,COG0367@2|Bacteria,3Y6CC@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_6164568_3	234267.Acid_4106	2.357e-100	334.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_6206221_0	1340493.JNIF01000003_gene2993	5.721e-256	800.0	COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HFD2_k127_6206221_1	1267535.KB906767_gene3126	3.858e-28	119.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_6227207_1	1340493.JNIF01000003_gene2485	3.871e-78	267.0	COG1596@1|root,COG1596@2|Bacteria,3Y7QA@57723|Acidobacteria	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_6227207_0	1267535.KB906767_gene3495	2.411e-90	305.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HFD2_k127_6227399_4	1340493.JNIF01000003_gene3965	1.051e-127	421.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_6227399_1	234267.Acid_7160	3.818e-187	595.0	COG0154@1|root,COG0154@2|Bacteria,3Y6WA@57723|Acidobacteria	57723|Acidobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD2_k127_6227399_0	1340493.JNIF01000003_gene2699	8.433e-205	648.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_dh_N
HFD2_k127_6227399_5	357808.RoseRS_4085	4.376e-79	276.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_6227399_6	234267.Acid_4357	3.013e-48	183.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	crtF	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_2,Methyltransf_23
HFD2_k127_6227399_8	1112214.AHIS01000027_gene1028	1.489e-09	70.0	COG1807@1|root,COG1807@2|Bacteria,1Q75Q@1224|Proteobacteria,2VDA2@28211|Alphaproteobacteria,2K93E@204457|Sphingomonadales	204457|Sphingomonadales	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6227399_7	247490.KSU1_D0904	2.578e-18	99.0	COG1807@1|root,COG1807@2|Bacteria,2J1H1@203682|Planctomycetes	203682|Planctomycetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_6227399_3	861299.J421_1661	1.533e-152	506.0	COG0534@1|root,COG0534@2|Bacteria,1ZUGI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HFD2_k127_6227399_2	234267.Acid_1245	2.21e-183	580.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_6228011_0	234267.Acid_6973	1.047e-285	885.0	COG1966@1|root,COG1966@2|Bacteria,3Y436@57723|Acidobacteria	57723|Acidobacteria	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HFD2_k127_6228011_6	1340493.JNIF01000003_gene1333	8.268e-98	332.0	COG4963@1|root,COG4963@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31
HFD2_k127_6228011_5	1340493.JNIF01000003_gene3432	4.287e-122	434.0	COG1629@1|root,COG1629@2|Bacteria,3Y765@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_6228011_1	1187851.A33M_0998	2.31e-202	635.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HFD2_k127_6228011_8	1123060.JONP01000009_gene2094	1.571e-64	227.0	COG0726@1|root,COG0726@2|Bacteria,1R8C6@1224|Proteobacteria,2U0HC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD2_k127_6228011_2	398525.KB900701_gene7408	2.003e-177	559.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria,3JW6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD2_k127_6228011_9	234267.Acid_6384	2.364e-62	222.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria	57723|Acidobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_6228011_7	234267.Acid_6383	3.828e-88	306.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_6228011_4	234267.Acid_6381	1.357e-129	421.0	COG0859@1|root,COG0859@2|Bacteria,3Y6NF@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_6228011_11	472759.Nhal_3966	1.092e-37	144.0	COG3636@1|root,COG3636@2|Bacteria,1N0RK@1224|Proteobacteria,1SNVV@1236|Gammaproteobacteria,1X1HT@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6228011_10	1096546.WYO_0495	7.116e-38	147.0	COG3657@1|root,COG3657@2|Bacteria,1N74C@1224|Proteobacteria,2UEMS@28211|Alphaproteobacteria,1JVIT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	addiction module killer protein	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD2_k127_6228011_3	234267.Acid_1498	3.527e-135	441.0	COG1030@1|root,COG1030@2|Bacteria,3Y31N@57723|Acidobacteria	57723|Acidobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HFD2_k127_6244230_5	1045855.DSC_03395	9.347e-60	211.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X3TV@135614|Xanthomonadales	135614|Xanthomonadales	M	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_6244230_2	1267535.KB906767_gene2443	6.786e-136	439.0	COG3872@1|root,COG3872@2|Bacteria,3Y66K@57723|Acidobacteria,2JKRW@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
HFD2_k127_6244230_1	234267.Acid_6670	3.113e-170	540.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria	57723|Acidobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_6244230_3	234267.Acid_6669	1.5e-96	327.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria	57723|Acidobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HFD2_k127_6244230_0	234267.Acid_0850	1.116e-182	583.0	COG0389@1|root,COG0389@2|Bacteria,3Y3NY@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD2_k127_6244230_4	1340493.JNIF01000004_gene606	1.302e-79	275.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_6245107_7	1267535.KB906767_gene515	7.335e-13	76.0	COG2271@1|root,COG2271@2|Bacteria,3Y6CQ@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD2_k127_6245107_4	1267535.KB906767_gene2203	1.681e-42	174.0	COG4783@1|root,COG4783@2|Bacteria,3Y7PN@57723|Acidobacteria	57723|Acidobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6245107_6	1267535.KB906767_gene3869	2.562e-35	143.0	COG3637@1|root,COG3637@2|Bacteria,3Y783@57723|Acidobacteria	57723|Acidobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HFD2_k127_6245107_2	1267535.KB906767_gene4511	2.894e-60	219.0	COG3637@1|root,COG3637@2|Bacteria,3Y783@57723|Acidobacteria	57723|Acidobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HFD2_k127_6245107_0	234267.Acid_6424	9.094e-247	787.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria	57723|Acidobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HFD2_k127_6245107_3	1267535.KB906767_gene3422	7.894e-47	177.0	COG3026@1|root,COG3026@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
HFD2_k127_6245107_1	1340493.JNIF01000003_gene2523	2.076e-98	324.0	COG1032@1|root,COG1032@2|Bacteria,3Y2QU@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD2_k127_6247999_0	234267.Acid_4061	2.244e-164	521.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,Dala_Dala_lig_C,RimK
HFD2_k127_6247999_2	136993.KB900627_gene392	2.571e-32	142.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6247999_1	1038859.AXAU01000002_gene647	3.246e-113	374.0	COG1520@1|root,COG1520@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_6251518_1	1340493.JNIF01000003_gene2519	7.668e-14	78.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_6251518_0	1340493.JNIF01000003_gene3331	6.853e-43	164.0	COG1943@1|root,COG1943@2|Bacteria,3Y81S@57723|Acidobacteria	57723|Acidobacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD2_k127_6251518_2	1340493.JNIF01000003_gene3331	4.537e-06	50.0	COG1943@1|root,COG1943@2|Bacteria,3Y81S@57723|Acidobacteria	57723|Acidobacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD2_k127_6285763_2	715451.ambt_12010	1.864e-09	67.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6285763_0	426117.M446_1962	6.308e-209	656.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U0GU@28211|Alphaproteobacteria,1JQZ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EGP	PFAM General substrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_6285763_3	1209072.ALBT01000032_gene2123	2.083e-09	68.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6285763_1	195250.CM001776_gene1121	1.379e-43	171.0	COG0491@1|root,COG0491@2|Bacteria,1G400@1117|Cyanobacteria,1H175@1129|Synechococcus	1117|Cyanobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_6294754_9	1095770.CAHE01000042_gene748	5.835e-09	61.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_6294754_2	1267535.KB906767_gene3243	1.919e-179	570.0	COG1972@1|root,COG1972@2|Bacteria,3Y2KI@57723|Acidobacteria,2JIKE@204432|Acidobacteriia	204432|Acidobacteriia	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
HFD2_k127_6294754_0	234267.Acid_5231	2.365e-196	619.0	COG0213@1|root,COG0213@2|Bacteria,3Y44B@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Glycosyl transferase, family	-	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD2_k127_6294754_1	1267535.KB906767_gene210	2.016e-187	595.0	COG3004@1|root,COG3004@2|Bacteria	2|Bacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
HFD2_k127_6294754_7	234267.Acid_2019	2.267e-40	152.0	2A0AW@1|root,30NEB@2|Bacteria,3Y96N@57723|Acidobacteria	57723|Acidobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HFD2_k127_6294754_3	401053.AciPR4_0063	1.47e-112	371.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_6294754_6	1282361.ABAC402_17875	2.712e-58	213.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4,Ank_5
HFD2_k127_6294754_5	234267.Acid_1311	8.05e-76	261.0	COG0631@1|root,COG0631@2|Bacteria,3Y7SC@57723|Acidobacteria	57723|Acidobacteria	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD2_k127_6294754_4	234267.Acid_1295	4.023e-100	340.0	COG0457@1|root,COG0457@2|Bacteria,3Y2VC@57723|Acidobacteria	57723|Acidobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HFD2_k127_6294754_8	1040986.ATYO01000003_gene5955	4.917e-11	68.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,2UEFM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	heat shock protein DnaJ	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ
HFD2_k127_6297370_1	313606.M23134_01028	2.809e-21	104.0	COG3182@1|root,COG3182@2|Bacteria,4NIWJ@976|Bacteroidetes,47M3U@768503|Cytophagia	976|Bacteroidetes	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HFD2_k127_6297370_2	1293048.CBMB010000006_gene3051	1.993e-12	76.0	arCOG08934@1|root,arCOG08934@2157|Archaea,2XXBA@28890|Euryarchaeota	28890|Euryarchaeota	Q	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_6297370_0	509190.Cseg_2356	5.621e-51	193.0	COG1506@1|root,COG1506@2|Bacteria,1R0PB@1224|Proteobacteria,2TYSM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6297370_3	365044.Pnap_0570	8.941e-07	59.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2VK61@28216|Betaproteobacteria,4ABNM@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase LRE domain protein	gnl1	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_6322764_1	1267535.KB906767_gene3025	3.835e-154	490.0	COG0364@1|root,COG0364@2|Bacteria,3Y2JZ@57723|Acidobacteria,2JHKE@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_6322764_7	1267535.KB906767_gene3026	3.843e-59	216.0	COG3429@1|root,COG3429@2|Bacteria,3Y7S9@57723|Acidobacteria	57723|Acidobacteria	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HFD2_k127_6322764_3	234267.Acid_5279	1.383e-80	274.0	COG0363@1|root,COG0363@2|Bacteria,3Y430@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD2_k127_6322764_2	1267535.KB906767_gene3028	5.22e-101	340.0	COG2843@1|root,COG2843@2|Bacteria,3Y8HU@57723|Acidobacteria	57723|Acidobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
HFD2_k127_6322764_8	234267.Acid_5312	2.271e-26	111.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HFD2_k127_6322764_0	1267535.KB906767_gene2982	1.038e-178	565.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
HFD2_k127_6322764_9	394221.Mmar10_0063	3.387e-26	113.0	COG3631@1|root,COG3631@2|Bacteria,1RD0K@1224|Proteobacteria,2UGFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HFD2_k127_6322764_4	313606.M23134_03563	1.561e-73	266.0	COG4099@1|root,COG4099@2|Bacteria,4NJFP@976|Bacteroidetes,47SYK@768503|Cytophagia	976|Bacteroidetes	S	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase
HFD2_k127_6322764_5	234267.Acid_0041	7.159e-65	233.0	COG4122@1|root,COG4122@2|Bacteria,3Y33U@57723|Acidobacteria	57723|Acidobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6331280_8	1128421.JAGA01000002_gene1496	1.861e-15	77.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
HFD2_k127_6331280_1	1267535.KB906767_gene5150	8.275e-190	600.0	2BXG3@1|root,2Z82R@2|Bacteria,3Y3HC@57723|Acidobacteria	57723|Acidobacteria	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
HFD2_k127_6331280_0	234267.Acid_5330	2.153e-224	702.0	COG1904@1|root,COG1904@2|Bacteria,3Y2S9@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
HFD2_k127_6331280_4	1267535.KB906767_gene3251	1.148e-175	561.0	COG2271@1|root,COG2271@2|Bacteria,3Y2KA@57723|Acidobacteria,2JI0V@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD2_k127_6331280_3	518766.Rmar_2391	1.311e-177	567.0	COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Glyco_hydro_88,Pectate_lyase_3
HFD2_k127_6331280_2	234267.Acid_1820	1.74e-189	600.0	COG2271@1|root,COG2271@2|Bacteria,3Y6PG@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6331280_5	1121106.JQKB01000006_gene1309	2.896e-45	181.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2TQSD@28211|Alphaproteobacteria,2JWRR@204441|Rhodospirillales	204441|Rhodospirillales	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_6331280_6	426117.M446_1625	4.86e-32	141.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2TQSD@28211|Alphaproteobacteria,1JQR8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_6331280_7	926554.KI912675_gene2265	3.452e-30	126.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_6331280_9	395963.Bind_0969	6.658e-11	69.0	COG4993@1|root,COG4993@2|Bacteria,1MUW1@1224|Proteobacteria,2U2KU@28211|Alphaproteobacteria,3NC1M@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
HFD2_k127_6348577_1	880073.Calab_0308	2.529e-18	88.0	COG2010@1|root,COG2010@2|Bacteria,2NPQJ@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	actE	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_6348577_0	1297742.A176_05066	4.648e-90	314.0	COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2WQ6N@28221|Deltaproteobacteria,2YY91@29|Myxococcales	28221|Deltaproteobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6404219_2	379066.GAU_2310	5.15e-17	82.0	COG3391@1|root,COG3391@2|Bacteria,1ZSNC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6404219_1	551789.ATVJ01000001_gene1038	6.416e-58	213.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,2UKQP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6404219_0	587753.EY04_20810	2.889e-102	340.0	COG0596@1|root,COG0596@2|Bacteria,1MWT6@1224|Proteobacteria,1RMFA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_6406563_1	234267.Acid_7828	8.155e-261	812.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_6406563_2	234267.Acid_2026	1.051e-226	717.0	COG1219@1|root,COG1219@2|Bacteria,3Y3MR@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD2_k127_6406563_0	1267535.KB906767_gene3175	0.0	1308.0	COG0466@1|root,COG0466@2|Bacteria,3Y3DI@57723|Acidobacteria,2JIB4@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD2_k127_6406563_4	1267535.KB906767_gene3176	1.159e-60	226.0	COG0218@1|root,COG0218@2|Bacteria,3Y4H6@57723|Acidobacteria,2JJC1@204432|Acidobacteriia	204432|Acidobacteriia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HFD2_k127_6406563_3	1267535.KB906767_gene3177	1.408e-192	610.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HFD2_k127_640659_1	555793.WSK_4047	4.006e-25	112.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_640659_2	1340493.JNIF01000003_gene2122	1.148e-24	108.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_640659_3	555793.WSK_4047	1.882e-20	102.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_640659_0	1267535.KB906767_gene3001	4.075e-171	541.0	COG4993@1|root,COG4993@2|Bacteria,3Y6CA@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_6444260_0	1267535.KB906767_gene3358	1.398e-128	415.0	COG1131@1|root,COG1131@2|Bacteria,3Y697@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6444260_1	1267535.KB906767_gene3357	4.701e-111	364.0	COG0842@1|root,COG0842@2|Bacteria,3Y2S4@57723|Acidobacteria,2JISC@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_6444260_4	234267.Acid_4013	2.779e-34	153.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6444260_2	1267535.KB906767_gene1083	4.106e-95	319.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,3Y43X@57723|Acidobacteria,2JIN3@204432|Acidobacteriia	204432|Acidobacteriia	K	Metal binding domain of Ada	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
HFD2_k127_6444260_3	1267533.KB906734_gene3824	5.207e-37	144.0	COG0577@1|root,COG0577@2|Bacteria,3Y76W@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6460755_3	1340493.JNIF01000003_gene1908	6.211e-20	99.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
HFD2_k127_6460755_1	1340493.JNIF01000003_gene1909	4.178e-70	251.0	COG4585@1|root,COG4585@2|Bacteria,3Y8CF@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_6460755_2	234267.Acid_7286	3.126e-62	219.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_6460755_0	234267.Acid_6368	1.223e-137	460.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD2_k127_6469915_3	1340493.JNIF01000003_gene2631	3.265e-92	315.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfbU	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_6469915_2	234267.Acid_1856	5.462e-171	554.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
HFD2_k127_6469915_4	234267.Acid_1857	4.128e-68	235.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_6469915_0	304371.MCP_0432	1.087e-272	858.0	COG0433@1|root,arCOG09167@1|root,arCOG00280@2157|Archaea,arCOG00286@2157|Archaea,arCOG09167@2157|Archaea	2157|Archaea	P	protein kinase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
HFD2_k127_6469915_6	1340493.JNIF01000003_gene1351	1.589e-47	189.0	COG1413@1|root,COG1413@2|Bacteria,3Y4Z5@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_6469915_1	234267.Acid_7736	3.303e-214	689.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
HFD2_k127_6469915_5	234267.Acid_5527	6.362e-58	203.0	COG2967@1|root,COG2967@2|Bacteria	2|Bacteria	P	mitochondrion morphogenesis	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HFD2_k127_6486560_9	234267.Acid_2215	6.132e-08	53.0	COG0673@1|root,COG0673@2|Bacteria,3Y6W6@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_6486560_8	292459.STH770	1.126e-50	193.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	1239|Firmicutes	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD2_k127_6486560_6	204669.Acid345_0903	2.572e-199	627.0	COG2115@1|root,COG2115@2|Bacteria,3Y841@57723|Acidobacteria,2JNHR@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the xylose isomerase family	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_6486560_5	204669.Acid345_0904	5.345e-200	634.0	COG1070@1|root,COG1070@2|Bacteria,3Y2V6@57723|Acidobacteria,2JJ35@204432|Acidobacteriia	204432|Acidobacteriia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_6486560_7	234267.Acid_2113	1.416e-70	248.0	COG2010@1|root,COG2010@2|Bacteria,3Y7M0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_6486560_2	234267.Acid_2112	5.557e-240	752.0	COG4993@1|root,COG4993@2|Bacteria,3Y73P@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_6486560_4	1128421.JAGA01000001_gene2416	1.386e-224	706.0	COG2160@1|root,COG2160@2|Bacteria	2|Bacteria	G	L-arabinose isomerase activity	araA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iLJ478.TM0276,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060	Arabinose_Iso_C,Arabinose_Isome
HFD2_k127_6486560_3	234267.Acid_5646	5.533e-229	713.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD2_k127_6486560_1	234267.Acid_5647	4.583e-295	915.0	COG3507@1|root,COG3507@2|Bacteria,3Y89B@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
HFD2_k127_6486560_0	234267.Acid_5357	8.486e-297	922.0	COG0129@1|root,COG0129@2|Bacteria,3Y3B1@57723|Acidobacteria	57723|Acidobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
HFD2_k127_6509924_2	945713.IALB_0185	4.223e-14	85.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_6509924_0	234267.Acid_0644	6.181e-28	129.0	COG3464@1|root,COG3464@2|Bacteria	234267.Acid_0644|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6509924_1	1161401.ASJA01000002_gene2659	5.377e-18	91.0	2E9ZF@1|root,3344X@2|Bacteria,1NZSD@1224|Proteobacteria,2UV5P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6520592_5	1267535.KB906767_gene3160	1.536e-15	76.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD2_k127_6520592_2	1340493.JNIF01000003_gene1774	1.215e-151	499.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD2_k127_6520592_7	484770.UFO1_2409	1.179e-05	52.0	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,4H4AJ@909932|Negativicutes	909932|Negativicutes	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD2_k127_6520592_4	330214.NIDE3247	1.139e-57	207.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HFD2_k127_6520592_1	1163617.SCD_n00935	5.893e-265	857.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria	1224|Proteobacteria	NT	Chemotaxis	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS,PAS_10,PAS_4
HFD2_k127_6520592_0	234267.Acid_7040	6.393e-286	889.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria	57723|Acidobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD2_k127_6520592_3	247633.GP2143_17791	1.603e-75	262.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6534860_3	1267535.KB906767_gene4866	4.52e-69	246.0	COG2863@1|root,COG2863@2|Bacteria	2|Bacteria	C	cytochrome	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3,DUF1566
HFD2_k127_6534860_1	196490.AUEZ01000013_gene4733	6.54e-89	299.0	COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2TVFV@28211|Alphaproteobacteria,3JQPU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_6534860_2	330214.NIDE1902	6.108e-75	260.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_6534860_4	136993.KB900627_gene392	9.53e-34	140.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6534860_0	682795.AciX8_3558	3.554e-176	565.0	COG1506@1|root,COG1506@2|Bacteria,3Y6MJ@57723|Acidobacteria,2JMBK@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_6534860_6	391735.Veis_4951	1.52e-11	66.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_6544213_1	234267.Acid_2032	1.745e-97	331.0	COG2960@1|root,COG2960@2|Bacteria	2|Bacteria	M	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_6544213_0	234267.Acid_5827	2.982e-235	751.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_6544213_2	1122169.AREN01000037_gene192	1.494e-07	56.0	COG0666@1|root,COG0666@2|Bacteria,1RE5N@1224|Proteobacteria,1S3Z5@1236|Gammaproteobacteria,1JDMW@118969|Legionellales	118969|Legionellales	S	Ankyrin repeat domain protein	ankH	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
HFD2_k127_6545800_10	234267.Acid_2180	8.159e-78	267.0	COG0500@1|root,COG2226@2|Bacteria,3Y7D3@57723|Acidobacteria	57723|Acidobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_6545800_2	234267.Acid_2181	1.765e-144	471.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase internal region	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
HFD2_k127_6545800_9	234267.Acid_2182	1.518e-89	306.0	COG0807@1|root,COG0807@2|Bacteria,3Y2I4@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HFD2_k127_6545800_5	234267.Acid_7145	4.676e-116	389.0	COG2204@1|root,COG2204@2|Bacteria,3Y6BK@57723|Acidobacteria	57723|Acidobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HFD2_k127_6545800_4	1340493.JNIF01000003_gene3616	1.645e-119	403.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene3616|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6545800_12	1121382.JQKG01000013_gene468	8.651e-31	125.0	COG2018@1|root,COG2018@2|Bacteria,1WKFF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HFD2_k127_6545800_1	1267535.KB906767_gene3930	3.596e-281	884.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria,2JI6E@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
HFD2_k127_6545800_15	234267.Acid_6643	1.029e-24	108.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ANAPC5,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
HFD2_k127_6545800_11	234267.Acid_6359	4.648e-33	131.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD2_k127_6545800_8	1038860.AXAP01000003_gene8378	6.823e-106	358.0	COG1252@1|root,COG1252@2|Bacteria,1N2QQ@1224|Proteobacteria,2TUT3@28211|Alphaproteobacteria,3JS5F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_6545800_0	234267.Acid_7045	8.579e-290	925.0	COG1404@1|root,COG1404@2|Bacteria,3Y5WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
HFD2_k127_6545800_6	234267.Acid_6604	1.032e-115	392.0	COG1413@1|root,COG1413@2|Bacteria,3Y6AH@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_6545800_3	1340493.JNIF01000003_gene2827	8.057e-139	445.0	COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HFD2_k127_6545800_16	1192034.CAP_7218	4.29e-21	97.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2YXI4@29|Myxococcales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
HFD2_k127_6545800_7	1340493.JNIF01000004_gene6	3.492e-114	381.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD2_k127_6568163_3	411154.GFO_0980	4.111e-14	75.0	COG1917@1|root,COG1917@2|Bacteria,4P2XE@976|Bacteroidetes,1IAY3@117743|Flavobacteriia	976|Bacteroidetes	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6568163_1	1267535.KB906767_gene4866	1.389e-143	463.0	COG2863@1|root,COG2863@2|Bacteria	2|Bacteria	C	cytochrome	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3,DUF1566
HFD2_k127_6568163_2	234267.Acid_3334	1.44e-77	271.0	COG3391@1|root,COG3391@2|Bacteria,3Y3R3@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_6568163_0	861299.J421_5885	1.124e-183	600.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1ZUID@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Hpt domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_6576334_2	1296990.H845_1013	7.156e-08	57.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,2JSK6@204441|Rhodospirillales	204441|Rhodospirillales	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HFD2_k127_6576334_0	991905.SL003B_0391	2.075e-22	102.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BRN6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HFD2_k127_6576334_1	1267533.KB906735_gene4850	6.58e-11	73.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6588290_11	1449049.JONW01000005_gene1059	4.021e-10	71.0	2C7KZ@1|root,32RJE@2|Bacteria,1N3NH@1224|Proteobacteria,2UCGT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_1	402777.KB235898_gene5725	4.71e-160	533.0	COG0001@1|root,COG1020@1|root,COG0001@2|Bacteria,COG1020@2|Bacteria,1G25N@1117|Cyanobacteria,1HA4D@1150|Oscillatoriales	1117|Cyanobacteria	HQ	Acyl transferase domain in polyketide synthase (PKS) enzymes.	mcyE	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt
HFD2_k127_6588290_10	1185876.BN8_00717	3.366e-10	65.0	COG2730@1|root,COG2730@2|Bacteria,4NXWZ@976|Bacteroidetes,47WUS@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_9	1209072.ALBT01000032_gene2123	5.61e-20	94.0	2C42J@1|root,3359Y@2|Bacteria,1NJYP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_8	1335760.ASTG01000003_gene1750	6.298e-23	112.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_5	234267.Acid_5825	4.473e-71	267.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	moxJ	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,SBP_bac_3
HFD2_k127_6588290_3	243090.RB598	8.172e-108	364.0	COG2960@1|root,COG2960@2|Bacteria,2J2KP@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_6588290_0	234267.Acid_5827	1.449e-211	690.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_6588290_7	247633.GP2143_17801	2.318e-39	157.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_6	247633.GP2143_18126	1.701e-49	191.0	28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,1ST6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_4	247633.GP2143_17791	1.687e-77	270.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6588290_2	234267.Acid_3725	6.806e-148	481.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_6613389_8	639030.JHVA01000001_gene2128	6.724e-55	207.0	COG1309@1|root,COG1309@2|Bacteria,3Y81U@57723|Acidobacteria,2JN95@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_6613389_4	234267.Acid_0771	7.704e-124	407.0	COG0763@1|root,COG0763@2|Bacteria,3Y34H@57723|Acidobacteria	57723|Acidobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HFD2_k127_6613389_0	234267.Acid_0772	5.912e-249	784.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
HFD2_k127_6613389_7	68170.KL590510_gene7215	5.756e-67	238.0	COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HFD2_k127_6613389_2	234267.Acid_0592	6.097e-154	490.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_6613389_6	555079.Toce_0450	7.306e-104	351.0	COG0477@1|root,COG2814@2|Bacteria,1UHNA@1239|Firmicutes,25F3B@186801|Clostridia,42J72@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HFD2_k127_6613389_3	1096546.WYO_3029	2.65e-135	436.0	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM formyl transferase domain protein	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD2_k127_6613389_1	375286.mma_2347	8.047e-183	580.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	CoA-transferase family III	-	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HFD2_k127_6613389_5	1445613.JALM01000020_gene4705	6.174e-117	384.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_6617884_6	1340493.JNIF01000003_gene2587	4.254e-12	67.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_6617884_2	234267.Acid_5992	4.93e-144	466.0	COG0842@1|root,COG0842@2|Bacteria,3Y73W@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_6617884_1	234267.Acid_7061	1.617e-144	483.0	COG0673@1|root,COG0673@2|Bacteria,3Y78W@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_6617884_0	1267535.KB906767_gene5472	1.343e-177	563.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_6617884_3	204669.Acid345_2365	6.39e-94	317.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD2_k127_6617884_5	234267.Acid_7059	2.54e-55	196.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria	57723|Acidobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,Glyoxalase_4
HFD2_k127_6617884_4	234267.Acid_7058	5.882e-90	300.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_6632698_2	1454010.JEOE01000034_gene1816	4.392e-13	73.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4F17R@85016|Cellulomonadaceae	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HFD2_k127_6632698_3	1382306.JNIM01000001_gene2932	1.563e-08	68.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_2,CHAT,ClpB_D2-small,Clp_N
HFD2_k127_6632698_1	926569.ANT_18470	1.144e-43	169.0	COG0625@1|root,COG3815@1|root,COG0625@2|Bacteria,COG3815@2|Bacteria,2G73B@200795|Chloroflexi	200795|Chloroflexi	O	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
HFD2_k127_6632698_0	1122609.AUGT01000005_gene1779	8.552e-96	324.0	COG0462@1|root,COG0462@2|Bacteria,2GKR2@201174|Actinobacteria,4DQ3C@85009|Propionibacteriales	201174|Actinobacteria	EF	Phosphoribosyl synthetase-associated domain	prs_1	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD2_k127_6650139_2	1267535.KB906767_gene1287	3.103e-100	336.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_6650139_1	1267535.KB906767_gene2758	1.772e-188	613.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Glyco_hydro_57,Polysacc_deac_1,SLH
HFD2_k127_6650139_4	1276920.ADIAG_01701	6.199e-05	55.0	COG2334@1|root,COG2334@2|Bacteria,2IB1T@201174|Actinobacteria,1W8XC@1268|Micrococcaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	APH
HFD2_k127_6650139_0	1340493.JNIF01000003_gene2812	0.0	1628.0	COG3459@1|root,COG3459@2|Bacteria,3Y3E9@57723|Acidobacteria	57723|Acidobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HFD2_k127_6660866_2	234267.Acid_0816	7.414e-94	317.0	COG0697@1|root,COG0697@2|Bacteria,3Y4NT@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6660866_0	1340493.JNIF01000003_gene2622	3.723e-112	370.0	COG1105@1|root,COG1105@2|Bacteria,3Y5F9@57723|Acidobacteria	57723|Acidobacteria	G	Phosphomethylpyrimidine kinase	-	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_6660866_3	1267535.KB906767_gene4068	1.123e-83	288.0	COG1018@1|root,COG1018@2|Bacteria,3Y4SB@57723|Acidobacteria,2JJAW@204432|Acidobacteriia	204432|Acidobacteriia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
HFD2_k127_6660866_6	234267.Acid_7485	3.355e-29	123.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HFD2_k127_6660866_5	234267.Acid_5364	2.35e-54	198.0	2EGFY@1|root,30MEN@2|Bacteria,3Y7VF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6660866_4	234267.Acid_4988	5.072e-77	263.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_6660866_1	234267.Acid_1391	7.907e-106	352.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	CTP_transf_3,HNH_4,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_6663399_3	65093.PCC7418_2799	8.798e-26	109.0	COG1724@1|root,COG1724@2|Bacteria,1G8WI@1117|Cyanobacteria	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_6663399_4	234267.Acid_7793	1.685e-24	104.0	COG1598@1|root,COG1598@2|Bacteria,3Y5U6@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6663399_0	234267.Acid_5429	0.0	1393.0	COG0841@1|root,COG0841@2|Bacteria,3Y63J@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD2_k127_6663399_2	234267.Acid_4790	4.636e-34	138.0	COG2825@1|root,COG2825@2|Bacteria,3Y8ID@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD2_k127_6663399_1	1340493.JNIF01000003_gene2431	8.49e-80	276.0	COG1524@1|root,COG1524@2|Bacteria,3Y4MJ@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_6669597_1	118166.JH976537_gene4962	9.741e-219	691.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G23H@1117|Cyanobacteria,1HEF2@1150|Oscillatoriales	1117|Cyanobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
HFD2_k127_6669597_8	234267.Acid_4100	9.097e-28	116.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_6669597_7	1046724.KB889862_gene1491	1.346e-29	126.0	293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,1S4U7@1236|Gammaproteobacteria,467DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6669597_6	913325.N799_05005	9.832e-85	291.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RNIU@1236|Gammaproteobacteria,1X5V2@135614|Xanthomonadales	135614|Xanthomonadales	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HFD2_k127_6669597_2	1128421.JAGA01000002_gene1223	1.674e-170	548.0	COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iAPECO1_1312.glcF,iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN678.glcF,iJN746.PP_3747,iUTI89_1310.glcF,ic_1306.glcF	CCG,Fer4_7,Fer4_8
HFD2_k127_6669597_4	1128421.JAGA01000002_gene1222	3.184e-114	380.0	COG0277@1|root,COG0277@2|Bacteria,2NP55@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_6669597_0	1128421.JAGA01000002_gene1221	1.799e-229	718.0	COG0277@1|root,COG0277@2|Bacteria,2NP2P@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
HFD2_k127_6669597_5	1209072.ALBT01000058_gene896	2.839e-99	335.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1FHT1@10|Cellvibrio	1236|Gammaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD2_k127_6669597_3	891968.Anamo_1078	1.602e-152	489.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD2_k127_6669597_9	1166130.H650_01265	3.078e-13	74.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,3WZXV@547|Enterobacter	1236|Gammaproteobacteria	M	Catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD2_k127_6714565_0	234267.Acid_4925	1.392e-309	955.0	COG3957@1|root,COG3957@2|Bacteria,3Y3XU@57723|Acidobacteria	57723|Acidobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HFD2_k127_6714565_2	861299.J421_3809	5.797e-216	684.0	COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD2_k127_6714565_9	1267535.KB906767_gene2875	3.824e-41	164.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria	57723|Acidobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_6714565_3	1267535.KB906767_gene2870	1.452e-208	666.0	COG2217@1|root,COG2217@2|Bacteria	2|Bacteria	P	Heavy metal translocating P-type atpase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
HFD2_k127_6714565_7	861299.J421_3013	9.455e-59	215.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	minD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
HFD2_k127_6714565_4	1267535.KB906767_gene4008	2.092e-201	633.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
HFD2_k127_6714565_12	317619.ANKN01000018_gene175	2.397e-26	116.0	COG4636@1|root,COG4636@2|Bacteria,1G599@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_6714565_10	1267534.KB906755_gene4131	2.005e-31	127.0	COG3801@1|root,COG3801@2|Bacteria	2|Bacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD2_k127_6714565_1	234267.Acid_2208	8.602e-238	743.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria	57723|Acidobacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
HFD2_k127_6714565_6	234267.Acid_1756	3.644e-110	363.0	COG1378@1|root,COG1378@2|Bacteria,3Y66F@57723|Acidobacteria	57723|Acidobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
HFD2_k127_6714565_8	1267535.KB906767_gene4147	1.315e-42	164.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yigB	-	3.1.3.10,3.1.3.102,3.1.3.104	ko:K07025,ko:K20862,ko:K20866	ko00010,ko00740,ko01100,ko01110,ko01120,map00010,map00740,map01100,map01110,map01120	M00125	R00548,R00947,R07280	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
HFD2_k127_6714565_5	1267535.KB906767_gene4148	1.002e-153	490.0	COG0463@1|root,COG0463@2|Bacteria,3Y30V@57723|Acidobacteria,2JIJ8@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_6714565_11	1340493.JNIF01000004_gene606	7.485e-27	111.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_6765893_0	1267535.KB906767_gene2631	2.63e-273	848.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria,2JHXX@204432|Acidobacteriia	204432|Acidobacteriia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_6765893_1	234267.Acid_0298	1.161e-144	476.0	COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria	57723|Acidobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD2_k127_6790116_2	234267.Acid_5530	6.988e-113	372.0	COG0475@1|root,COG0475@2|Bacteria,3Y5D3@57723|Acidobacteria	57723|Acidobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD2_k127_6790116_1	234267.Acid_1901	1.716e-266	827.0	COG0174@1|root,COG0174@2|Bacteria,3Y2P8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Glutamine synthetase, catalytic	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_6790116_3	234267.Acid_0068	2.647e-50	183.0	COG2258@1|root,COG2258@2|Bacteria,3Y820@57723|Acidobacteria	57723|Acidobacteria	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HFD2_k127_6790116_0	234267.Acid_0069	6.159e-308	970.0	COG1391@1|root,COG1391@2|Bacteria,3Y72J@57723|Acidobacteria	57723|Acidobacteria	H	Glutamate-ammonia ligase adenylyltransferase	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HFD2_k127_6790116_4	684949.ATTJ01000002_gene147	5.539e-07	52.0	COG1028@1|root,COG1028@2|Bacteria,1WKXM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_6792127_1	234267.Acid_7677	7.966e-59	209.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD2_k127_6792127_2	1123319.AUBE01000016_gene5918	3.734e-15	81.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria	201174|Actinobacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_6792127_0	234267.Acid_5704	1.527e-184	585.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
HFD2_k127_6792600_9	935840.JAEQ01000001_gene3217	4.194e-05	54.0	COG2010@1|root,COG2010@2|Bacteria,1NBIA@1224|Proteobacteria,2UHSH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_6792600_8	869210.Marky_0880	4.14e-07	58.0	COG2335@1|root,COG2335@2|Bacteria,1WNHM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	CHRD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HFD2_k127_6792600_5	204669.Acid345_2669	3.521e-68	239.0	COG0744@1|root,COG0744@2|Bacteria,3Y48X@57723|Acidobacteria,2JKAG@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HFD2_k127_6792600_4	1124780.ANNU01000078_gene768	7.292e-74	255.0	COG4221@1|root,COG4221@2|Bacteria,4NFSY@976|Bacteroidetes,47PUC@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
HFD2_k127_6792600_3	234267.Acid_3083	6.531e-86	292.0	COG3595@1|root,COG3595@2|Bacteria,3Y5AF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6792600_6	861299.J421_1249	1.684e-37	146.0	2AG3M@1|root,31687@2|Bacteria,1ZV0Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6792600_1	1095769.CAHF01000011_gene2117	3.299e-124	404.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153,4.2.1.56	ko:K09709,ko:K18291	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R02491,R09282	RC00730,RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
HFD2_k127_6792600_2	234267.Acid_2349	2.244e-99	340.0	COG2271@1|root,COG2271@2|Bacteria,3Y7EW@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HFD2_k127_6792600_7	861299.J421_0735	6.001e-21	100.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_0735|-	S	peptidyl-tyrosine sulfation	-	-	-	ko:K13992	-	-	-	-	ko00000,ko00194	-	-	-	-
HFD2_k127_6806641_0	1082931.KKY_2582	4.211e-191	608.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_6813329_2	378806.STAUR_6894	3.581e-51	188.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria	1224|Proteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_6813329_4	936455.KI421499_gene7124	2.216e-42	160.0	COG1520@1|root,COG1520@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_6813329_5	172088.AUGA01000007_gene8332	2.341e-26	118.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_6813329_3	401053.AciPR4_2706	4.66e-51	196.0	COG2355@1|root,COG2355@2|Bacteria,3Y3RS@57723|Acidobacteria,2JKHH@204432|Acidobacteriia	204432|Acidobacteriia	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD2_k127_6813329_1	1346791.M529_18860	1.734e-55	207.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_6813329_0	246196.MSMEI_4288	7.812e-56	213.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_6813329_7	555793.WSK_4047	1.197e-17	94.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6813329_8	639030.JHVA01000001_gene1885	5.491e-15	79.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6813329_6	555793.WSK_4047	9.384e-26	119.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6813329_9	1340493.JNIF01000003_gene2122	6.619e-06	57.0	2A8SF@1|root,30XV5@2|Bacteria,3Y8QM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6855987_3	335543.Sfum_1483	0.0004557	49.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MRYE@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD2_k127_6855987_1	234267.Acid_1297	1.193e-97	327.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD2_k127_6855987_0	1267535.KB906767_gene829	1.294e-186	604.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD2_k127_6855987_2	234267.Acid_0822	6.671e-67	233.0	COG1524@1|root,COG1524@2|Bacteria,3Y4MJ@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_6881751_4	234267.Acid_0826	7.903e-89	295.0	COG0803@1|root,COG0803@2|Bacteria,3Y97A@57723|Acidobacteria	57723|Acidobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
HFD2_k127_6881751_1	234267.Acid_0827	9.144e-132	424.0	COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria	57723|Acidobacteria	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HFD2_k127_6881751_0	234267.Acid_0103	1.012e-195	623.0	COG0477@1|root,COG2814@2|Bacteria,3Y2YV@57723|Acidobacteria	57723|Acidobacteria	EGP	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HFD2_k127_6881751_5	234267.Acid_3467	4.004e-52	192.0	2F4XC@1|root,33XJD@2|Bacteria,3Y7TM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6881751_3	1267535.KB906767_gene2144	2.298e-91	311.0	COG0354@1|root,COG0354@2|Bacteria,3Y2PI@57723|Acidobacteria,2JJ3H@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HFD2_k127_6881751_2	234267.Acid_7929	2.765e-93	317.0	COG0491@1|root,COG0491@2|Bacteria,3Y4DN@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_6881751_7	1382356.JQMP01000003_gene1755	4.491e-15	85.0	COG1956@1|root,COG1956@2|Bacteria,2GA0T@200795|Chloroflexi,27YG6@189775|Thermomicrobia	189775|Thermomicrobia	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
HFD2_k127_6881751_6	1340493.JNIF01000003_gene3080	1.892e-18	85.0	COG0457@1|root,COG0789@1|root,COG0457@2|Bacteria,COG0789@2|Bacteria,3Y3EM@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
HFD2_k127_6912735_9	234267.Acid_4321	9.113e-64	231.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_6912735_7	234267.Acid_4320	6.941e-85	287.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_6912735_14	1537715.JQFJ01000002_gene595	2.423e-15	90.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales	204457|Sphingomonadales	QU	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HFD2_k127_6912735_16	218284.CCDN010000001_gene445	0.0005366	53.0	COG4932@1|root,COG4932@2|Bacteria,1TQBI@1239|Firmicutes,4HBAT@91061|Bacilli,1ZD6Z@1386|Bacillus	91061|Bacilli	M	cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cna_B,Collagen_bind,Gram_pos_anchor,MucBP
HFD2_k127_6912735_5	234267.Acid_6229	4.207e-118	391.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_6912735_12	935863.AWZR01000003_gene2845	1.991e-38	159.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X7Y9@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferases group 1	-	-	-	ko:K21001	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HFD2_k127_6912735_15	1396418.BATQ01000106_gene5357	4.104e-06	59.0	28IVM@1|root,2Z8U0@2|Bacteria,46S57@74201|Verrucomicrobia,2IVM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6912735_10	1382356.JQMP01000003_gene1617	2.177e-50	200.0	COG2206@1|root,COG2206@2|Bacteria,2GBKK@200795|Chloroflexi	200795|Chloroflexi	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
HFD2_k127_6912735_13	1192034.CAP_1503	2.664e-31	132.0	COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,434YV@68525|delta/epsilon subdivisions,2WZ9S@28221|Deltaproteobacteria,2Z1NI@29|Myxococcales	28221|Deltaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6912735_4	234267.Acid_4104	2.336e-127	417.0	COG0845@1|root,COG0845@2|Bacteria,3Y6UQ@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6912735_3	234267.Acid_4103	1.39e-151	490.0	COG0845@1|root,COG0845@2|Bacteria,3Y7DU@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
HFD2_k127_6912735_2	234267.Acid_4102	2.921e-166	532.0	COG0845@1|root,COG0845@2|Bacteria,3Y6E7@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6912735_0	234267.Acid_4101	5.939e-212	665.0	COG0577@1|root,COG0577@2|Bacteria,3Y6CK@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_6912735_1	1267535.KB906767_gene2503	6.11e-175	554.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria,2JHZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD2_k127_6912735_8	1267535.KB906767_gene2504	1.563e-81	283.0	COG3347@1|root,COG3347@2|Bacteria	2|Bacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_6912735_6	1340493.JNIF01000004_gene755	4.93e-109	367.0	COG2382@1|root,COG2382@2|Bacteria,3Y5EH@57723|Acidobacteria	57723|Acidobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD2_k127_6912735_11	208439.AJAP_16930	4.532e-44	167.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_6914436_0	671143.DAMO_2028	1.468e-72	251.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
HFD2_k127_6914436_2	1340493.JNIF01000004_gene1195	0.0009153	44.0	2C5BF@1|root,33YZS@2|Bacteria,3Y84V@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6914436_1	1134474.O59_000874	0.0001176	55.0	COG3525@1|root,COG3525@2|Bacteria,1MVDE@1224|Proteobacteria,1RMNI@1236|Gammaproteobacteria,1FGD8@10|Cellvibrio	1236|Gammaproteobacteria	G	beta-acetyl hexosaminidase like	nahA	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,Glyco_hydro_20,Glyco_hydro_20b
HFD2_k127_6933176_1	1232410.KI421425_gene1538	1.857e-37	156.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,43T80@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	PEGA,Plug,TonB_dep_Rec
HFD2_k127_6933176_0	1267535.KB906767_gene2721	1.019e-151	486.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria,2JIUD@204432|Acidobacteriia	204432|Acidobacteriia	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_6949709_2	62928.azo2419	1.417e-83	291.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,2KU96@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6949709_5	1267535.KB906767_gene2186	2.977e-54	201.0	2F776@1|root,33ZNH@2|Bacteria,3Y8A6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6949709_4	1210884.HG799468_gene13687	6.022e-61	225.0	COG3971@1|root,COG3971@2|Bacteria	2|Bacteria	Q	2-oxopent-4-enoate hydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_6949709_6	1150621.SMUL_2179	8.778e-39	162.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42SEM@68525|delta/epsilon subdivisions,2YPMI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_6949709_0	234267.Acid_7854	4.961e-242	756.0	COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD2_k127_6949709_1	1267535.KB906767_gene2655	8.001e-128	411.0	COG1209@1|root,COG1209@2|Bacteria,3Y2ZJ@57723|Acidobacteria,2JIYE@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_6949709_3	234267.Acid_7389	1.098e-64	227.0	COG0332@1|root,COG0332@2|Bacteria	2|Bacteria	I	beta-ketoacyl-acyl-carrier-protein synthase III activity	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD2_k127_6959157_0	1267535.KB906767_gene39	5.269e-265	832.0	COG0577@1|root,COG0577@2|Bacteria,3Y47F@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6959157_7	1267535.KB906767_gene3833	1.467e-48	176.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia	2|Bacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_6959157_6	1340493.JNIF01000004_gene324	2.96e-79	279.0	COG0642@1|root,COG0642@2|Bacteria,3Y9DC@57723|Acidobacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,PAS_3,Response_reg,SnoaL_3
HFD2_k127_6959157_5	234267.Acid_5311	2.047e-81	278.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6959157_1	234267.Acid_5310	8.834e-183	588.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria	57723|Acidobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_6959157_2	234267.Acid_7028	1.797e-140	460.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	gatA3	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_6959157_4	1340493.JNIF01000003_gene4081	6.813e-129	416.0	COG3959@1|root,COG3959@2|Bacteria,3Y4PX@57723|Acidobacteria	57723|Acidobacteria	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_6959157_3	234267.Acid_2452	3.307e-133	432.0	COG3958@1|root,COG3958@2|Bacteria,3Y7P5@57723|Acidobacteria	57723|Acidobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_6959157_8	861299.J421_0271	1.984e-06	53.0	COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_7027288_0	1235802.C823_04890	1.822e-18	98.0	COG5433@1|root,COG5433@2|Bacteria,1V0JK@1239|Firmicutes,249XC@186801|Clostridia	186801|Clostridia	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HFD2_k127_7027288_2	391038.Bphy_7610	3.696e-10	65.0	2DSZ1@1|root,33HZU@2|Bacteria,1PXZ0@1224|Proteobacteria,2WD9I@28216|Betaproteobacteria,1K9SN@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7027288_1	234267.Acid_4382	1.725e-13	72.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria	57723|Acidobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HFD2_k127_7049533_13	234267.Acid_2763	5.785e-17	90.0	COG3291@1|root,COG4625@1|root,COG3291@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	2|Bacteria	M	PKD domain containing protein	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_3_5,DUF1080,He_PIG,PATR
HFD2_k127_7049533_5	234267.Acid_0422	1.377e-43	166.0	292F3@1|root,2ZPZC@2|Bacteria,3Y90G@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7049533_10	1267533.KB906734_gene3979	1.089e-21	100.0	2A09E@1|root,30NCR@2|Bacteria,3Y8XP@57723|Acidobacteria,2JNU4@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7049533_8	1111121.HMPREF1247_1046	8.868e-26	121.0	COG2208@1|root,COG2208@2|Bacteria,2GJSK@201174|Actinobacteria,4CV7N@84998|Coriobacteriia	84998|Coriobacteriia	T	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS,SpoIIE
HFD2_k127_7049533_4	381666.H16_B0376	3.136e-58	218.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1QY14@1224|Proteobacteria,2WH9F@28216|Betaproteobacteria,1KBXM@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
HFD2_k127_7049533_0	1163617.SCD_n00719	0.0	1247.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
HFD2_k127_7049533_6	204669.Acid345_2518	7.18e-39	153.0	2DP3Z@1|root,342RZ@2|Bacteria,3Y891@57723|Acidobacteria,2JNCK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7049533_1	1267535.KB906767_gene3728	5.45e-178	575.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_7049533_3	234267.Acid_2964	4.75e-105	345.0	COG2930@1|root,COG2930@2|Bacteria,3Y6Q0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_7049533_2	240015.ACP_0475	3.257e-152	507.0	COG3829@1|root,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria,2JHJS@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Sigma54_activat
HFD2_k127_7049533_12	1123508.JH636439_gene1256	4.603e-18	88.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_7049533_7	1340493.JNIF01000003_gene4646	8.242e-28	116.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD2_k127_7049533_11	1267535.KB906767_gene3726	1.732e-21	97.0	2A08J@1|root,30NBU@2|Bacteria,3Y8SW@57723|Acidobacteria,2JNXI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7086696_2	234267.Acid_4552	2.218e-50	182.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_7086696_1	234267.Acid_4552	7.457e-111	370.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_7086696_3	1121022.ABENE_00575	7.807e-12	69.0	COG3668@1|root,COG3668@2|Bacteria,1NEBD@1224|Proteobacteria,2UI0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HFD2_k127_7086696_0	234267.Acid_7856	7.489e-132	427.0	COG0305@1|root,COG0305@2|Bacteria,3Y335@57723|Acidobacteria	57723|Acidobacteria	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD2_k127_7092071_3	671143.DAMO_0166	2.322e-08	58.0	2EIBB@1|root,33C2R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7092071_2	1267535.KB906767_gene5072	1.322e-31	135.0	COG4758@1|root,COG4758@2|Bacteria,3Y554@57723|Acidobacteria,2JNA4@204432|Acidobacteriia	204432|Acidobacteriia	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
HFD2_k127_7092071_0	1267535.KB906767_gene5071	9.896e-90	306.0	COG2972@1|root,COG2972@2|Bacteria,3Y4BE@57723|Acidobacteria,2JMFY@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HFD2_k127_7092071_1	204669.Acid345_3487	4.672e-58	206.0	COG3279@1|root,COG3279@2|Bacteria,3Y3B3@57723|Acidobacteria,2JP1W@204432|Acidobacteriia	204432|Acidobacteriia	KT	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_7095401_0	1267535.KB906767_gene2350	3.549e-267	828.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_7095401_2	1267535.KB906767_gene2963	3.962e-179	572.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria,2JIAS@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD2_k127_7095401_5	1123288.SOV_3c05260	1.226e-96	329.0	COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,4H2CH@909932|Negativicutes	909932|Negativicutes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
HFD2_k127_7095401_6	234267.Acid_0555	6.64e-86	299.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
HFD2_k127_7095401_7	1267535.KB906767_gene2266	9.403e-69	243.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_7095401_3	489825.LYNGBM3L_52760	1.491e-167	546.0	COG2304@1|root,COG2304@2|Bacteria,1G3PE@1117|Cyanobacteria,1H7T7@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
HFD2_k127_7095401_10	1121456.ATVA01000015_gene2286	5.606e-34	143.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,2MBDI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	hydrolase, HAD-superfamily, subfamily IIIA	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HFD2_k127_7095401_11	240015.ACP_0744	6.487e-33	140.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,3Y303@57723|Acidobacteria,2JINA@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HFD2_k127_7095401_4	234267.Acid_0550	5.321e-112	370.0	COG2870@1|root,COG2870@2|Bacteria,3Y303@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HFD2_k127_7095401_12	234267.Acid_0890	2.686e-28	117.0	2C9DB@1|root,2ZU09@2|Bacteria,3Y8XC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7095401_13	683083.C414_000080020	1.128e-13	76.0	COG3108@1|root,COG3108@2|Bacteria,1Q5N3@1224|Proteobacteria,42XNX@68525|delta/epsilon subdivisions,2YT0B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
HFD2_k127_7095401_1	1267535.KB906767_gene3607	1.615e-221	698.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria,2JIY6@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD2_k127_7095401_9	1267535.KB906767_gene3606	3.467e-44	169.0	COG1544@1|root,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808,ko:K05809	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HFD2_k127_7095401_8	1340493.JNIF01000003_gene2754	4.982e-49	178.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria	57723|Acidobacteria	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD2_k127_7102622_3	234267.Acid_4761	4.26e-91	302.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_7102622_17	1267535.KB906767_gene179	2.198e-15	79.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7102622_18	927704.SELR_11000	2.311e-09	61.0	COG1724@1|root,COG1724@2|Bacteria,1VKIY@1239|Firmicutes,4H69A@909932|Negativicutes	909932|Negativicutes	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD2_k127_7102622_5	1230476.C207_00790	2.265e-76	261.0	COG2910@1|root,COG2910@2|Bacteria,1MV9B@1224|Proteobacteria,2TRZ3@28211|Alphaproteobacteria,3JTF3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NmrA-like family	MA20_08400	-	-	ko:K07118	-	-	-	-	ko00000	-	-	-	NAD_binding_10
HFD2_k127_7102622_1	1267535.KB906767_gene820	4.053e-154	490.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD2_k127_7102622_7	1267535.KB906767_gene819	7.784e-64	224.0	COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HFD2_k127_7102622_13	1340493.JNIF01000004_gene799	3.55e-34	139.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
HFD2_k127_7102622_4	1267535.KB906767_gene3988	1.972e-81	274.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HFD2_k127_7102622_14	1340493.JNIF01000004_gene532	2.875e-33	133.0	COG0720@1|root,COG0720@2|Bacteria,3Y56Y@57723|Acidobacteria	57723|Acidobacteria	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD2_k127_7102622_9	1267535.KB906767_gene3986	2.847e-56	199.0	COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria,2JJD0@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD2_k127_7102622_10	1267535.KB906767_gene3985	6.345e-48	177.0	COG0526@1|root,COG0526@2|Bacteria,3Y4UN@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_7102622_16	1267535.KB906767_gene450	1.952e-23	107.0	2FHG9@1|root,349AB@2|Bacteria,3Y8GZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7102622_11	1267535.KB906767_gene3549	1.236e-41	158.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HFD2_k127_7102622_6	1340493.JNIF01000003_gene2552	4.318e-68	235.0	COG0634@1|root,COG0634@2|Bacteria,3Y2FD@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HFD2_k127_7102622_12	595460.RRSWK_01389	4.657e-37	143.0	COG0614@1|root,COG0614@2|Bacteria,2J0J0@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD2_k127_7102622_8	234267.Acid_1834	9.671e-62	222.0	COG2755@1|root,COG2755@2|Bacteria,3Y4S6@57723|Acidobacteria	57723|Acidobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HFD2_k127_7102622_2	1267534.KB906756_gene446	1.344e-93	312.0	COG4181@1|root,COG4181@2|Bacteria,3Y3RU@57723|Acidobacteria,2JI42@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7102622_0	234267.Acid_1832	1.25e-245	784.0	COG3127@1|root,COG3127@2|Bacteria,3Y2PA@57723|Acidobacteria	57723|Acidobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7110880_6	1346791.M529_05410	3.277e-77	261.0	COG0654@1|root,COG0654@2|Bacteria,1N6PD@1224|Proteobacteria,2U19F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD2_k127_7110880_1	1346791.M529_05390	1.608e-182	580.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HFD2_k127_7110880_7	543728.Vapar_3212	3.86e-58	209.0	COG1786@1|root,COG1786@2|Bacteria,1RH5T@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HFD2_k127_7110880_5	756272.Plabr_2636	4.707e-85	297.0	28J2H@1|root,2Z8YZ@2|Bacteria,2IWTN@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7110880_3	1346791.M529_05405	2.431e-127	421.0	COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2URTW@28211|Alphaproteobacteria,2KCKR@204457|Sphingomonadales	204457|Sphingomonadales	G	Sugar (and other) transporter	-	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1
HFD2_k127_7110880_4	1247963.JPHU01000001_gene2058	2.794e-88	313.0	COG0477@1|root,COG0477@2|Bacteria,1QU36@1224|Proteobacteria,2TVXA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K07552,ko:K18552	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.3	-	-	MFS_1
HFD2_k127_7110880_0	234267.Acid_0987	0.0	1026.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,3Y2UX@57723|Acidobacteria	57723|Acidobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K13503,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
HFD2_k127_7110880_2	1267535.KB906767_gene2587	1.513e-141	459.0	COG3349@1|root,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria,2JIW6@204432|Acidobacteriia	204432|Acidobacteriia	C	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_7114544_0	234267.Acid_3470	2.963e-187	612.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7149720_4	234267.Acid_2348	2.393e-11	64.0	COG2952@1|root,COG2952@2|Bacteria,3Y55F@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
HFD2_k127_7149720_0	234267.Acid_5749	1.96e-206	672.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_7149720_2	697282.Mettu_2226	4.875e-55	196.0	COG1917@1|root,COG1917@2|Bacteria,1QEE2@1224|Proteobacteria,1SEI9@1236|Gammaproteobacteria,1XF2Z@135618|Methylococcales	135618|Methylococcales	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7149720_1	1340493.JNIF01000003_gene2355	1.077e-59	214.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Big_3_2,DUF4157,DUF922,OmpA,PA14
HFD2_k127_7149720_3	251221.35211765	1.678e-51	200.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7151034_9	234267.Acid_0778	4.597e-43	169.0	COG2379@1|root,COG2379@2|Bacteria,3Y2XC@57723|Acidobacteria	57723|Acidobacteria	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HFD2_k127_7151034_4	234267.Acid_0777	1.894e-57	204.0	COG0703@1|root,COG0703@2|Bacteria,3Y7UK@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HFD2_k127_7151034_5	1267535.KB906767_gene4292	1.602e-56	203.0	COG2802@1|root,COG2802@2|Bacteria,3Y7UX@57723|Acidobacteria	57723|Acidobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LON_substr_bdg
HFD2_k127_7151034_2	234267.Acid_0773	7.232e-91	308.0	COG1011@1|root,COG1011@2|Bacteria,3Y4BM@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HFD2_k127_7151034_10	448385.sce2478	7.324e-38	154.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	DUF4123,FHA,GAF_2,Yop-YscD_cpl
HFD2_k127_7151034_6	234267.Acid_5628	4.029e-55	201.0	COG1214@1|root,COG1214@2|Bacteria,3Y5ED@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_7151034_1	234267.Acid_5629	7.422e-155	506.0	COG5512@1|root,COG5512@2|Bacteria,3Y7CI@57723|Acidobacteria	57723|Acidobacteria	S	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
HFD2_k127_7151034_0	1267535.KB906767_gene2198	1.338e-167	533.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,FlgD_ig,NHL
HFD2_k127_7151034_8	234267.Acid_4085	2.277e-51	203.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	AhpC-TSA,CarboxypepD_reg,PDZ_2,Plug,TonB_dep_Rec
HFD2_k127_7151034_7	391625.PPSIR1_08202	8.771e-53	199.0	KOG1584@1|root,32BW5@2|Bacteria,1PW91@1224|Proteobacteria,42YNQ@68525|delta/epsilon subdivisions,2WTQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
HFD2_k127_7151034_3	1405.DJ92_3414	2.409e-68	242.0	COG0491@1|root,COG0491@2|Bacteria,1U974@1239|Firmicutes,4IJ9B@91061|Bacilli,1ZN0N@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7173589_6	61273.S3C9Q6	0.0005817	44.0	COG0666@1|root,KOG4177@2759|Eukaryota,39SBV@33154|Opisthokonta,3NYMI@4751|Fungi	4751|Fungi	M	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_4,NACHT
HFD2_k127_7173589_1	1121033.AUCF01000016_gene5495	2.958e-121	404.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2TSVE@28211|Alphaproteobacteria,2JQ2G@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD binding domain	-	-	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
HFD2_k127_7173589_2	1123073.KB899241_gene2073	4.873e-121	404.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria,1X353@135614|Xanthomonadales	135614|Xanthomonadales	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
HFD2_k127_7173589_4	663610.JQKO01000003_gene1497	2.677e-39	164.0	COG3386@1|root,COG3386@2|Bacteria,1MXB7@1224|Proteobacteria,2U2RZ@28211|Alphaproteobacteria,3NAAE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HFD2_k127_7173589_0	1038866.KB902813_gene2034	1.373e-126	427.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_7173589_3	1123508.JH636440_gene2302	9.082e-49	186.0	COG2755@1|root,COG2755@2|Bacteria,2IZ2H@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_7173589_5	321327.CYA_2304	7.475e-37	148.0	COG2133@1|root,COG2133@2|Bacteria,1G2QD@1117|Cyanobacteria,1GYDW@1129|Synechococcus	1117|Cyanobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
HFD2_k127_7195273_1	234267.Acid_3413	1.623e-219	689.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7195273_2	1267535.KB906767_gene591	1.444e-216	696.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia	204432|Acidobacteriia	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
HFD2_k127_7195273_9	1267535.KB906767_gene2595	8.13e-50	197.0	2CNUX@1|root,32SHU@2|Bacteria,3Y87T@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
HFD2_k127_7195273_0	234267.Acid_0981	0.0	1187.0	COG0443@1|root,COG0443@2|Bacteria,3Y7FW@57723|Acidobacteria	57723|Acidobacteria	O	DNA-K related protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
HFD2_k127_7195273_10	926566.Terro_0882	8.407e-50	188.0	COG0611@1|root,COG0611@2|Bacteria,3Y30U@57723|Acidobacteria,2JHT0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_7195273_5	234267.Acid_1083	3.223e-111	367.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	2|Bacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HFD2_k127_7195273_3	234267.Acid_6208	9.723e-188	600.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
HFD2_k127_7195273_11	234267.Acid_6209	1.024e-45	170.0	COG0723@1|root,COG0723@2|Bacteria,3Y7YJ@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD2_k127_7195273_8	234267.Acid_5566	2.249e-55	202.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7195273_12	1267535.KB906767_gene4113	1.427e-44	171.0	COG2940@1|root,COG2940@2|Bacteria,3Y7R1@57723|Acidobacteria	57723|Acidobacteria	S	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD2_k127_7195273_4	1123060.JONP01000032_gene1857	6.194e-121	400.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria,2JQV5@204441|Rhodospirillales	204441|Rhodospirillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7195273_7	1380394.JADL01000002_gene1283	3.006e-58	206.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,2JSN6@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_7195273_6	1038860.AXAP01000021_gene5518	6.991e-99	332.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2U157@28211|Alphaproteobacteria,3JRTW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_14105	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_7202857_5	1042163.BRLA_c024090	2.69e-17	92.0	COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,4HA1I@91061|Bacilli,272U5@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_7202857_0	234267.Acid_7363	1.372e-141	464.0	COG3359@1|root,COG3359@2|Bacteria,3Y6WT@57723|Acidobacteria	57723|Acidobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HFD2_k127_7202857_3	1267535.KB906767_gene3018	6.781e-31	126.0	COG0776@1|root,COG0776@2|Bacteria,3Y5E1@57723|Acidobacteria,2JJN0@204432|Acidobacteriia	204432|Acidobacteriia	L	Bacterial DNA-binding protein	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_7202857_6	1267535.KB906767_gene3019	4.773e-14	76.0	COG1826@1|root,COG1826@2|Bacteria,3Y5V7@57723|Acidobacteria	57723|Acidobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_7202857_4	234267.Acid_6699	9.148e-27	111.0	COG2146@1|root,COG2146@2|Bacteria,3Y5NP@57723|Acidobacteria	57723|Acidobacteria	P	PFAM Rieske 2Fe-2S	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD2_k127_7202857_1	234267.Acid_6700	2.066e-94	316.0	COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria	57723|Acidobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_7202857_2	234267.Acid_7393	2.465e-82	281.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_7205141_1	395965.Msil_2521	1.231e-107	362.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_7205141_0	509635.N824_10830	2.426e-187	600.0	COG2272@1|root,COG2272@2|Bacteria,4NG5B@976|Bacteroidetes,1IQQB@117747|Sphingobacteriia	976|Bacteroidetes	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HFD2_k127_7205141_2	1234364.AMSF01000088_gene2732	6.907e-89	301.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,1S2ZV@1236|Gammaproteobacteria,1X47K@135614|Xanthomonadales	135614|Xanthomonadales	ET	Bacterial periplasmic substrate-binding proteins	moxJ	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Ank_5,SBP_bac_3
HFD2_k127_7210139_1	1379270.AUXF01000001_gene2134	4.43e-55	196.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	oxlT	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HFD2_k127_7210139_0	1267535.KB906767_gene4290	2.459e-188	600.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_7210139_2	234267.Acid_0119	9.391e-49	177.0	COG1008@1|root,COG1008@2|Bacteria,3Y312@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD2_k127_7236330_10	28229.ND2E_4151	6.12e-82	276.0	COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,1S4R1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_7236330_4	639030.JHVA01000001_gene1500	3.938e-153	493.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD2_k127_7236330_1	234267.Acid_7167	1.916e-317	994.0	COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria	57723|Acidobacteria	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
HFD2_k127_7236330_12	234267.Acid_7487	1.225e-55	201.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HFD2_k127_7236330_8	1340493.JNIF01000004_gene396	4.717e-92	308.0	COG1028@1|root,COG1028@2|Bacteria	1340493.JNIF01000004_gene396|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7236330_2	234267.Acid_1848	2.834e-182	581.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7236330_3	234267.Acid_1847	1.467e-173	552.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria	57723|Acidobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_7236330_9	1340493.JNIF01000004_gene680	2.25e-82	279.0	COG3375@1|root,COG3375@2|Bacteria,3Y41E@57723|Acidobacteria	57723|Acidobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_7236330_7	234267.Acid_1845	3.23e-99	331.0	COG1694@1|root,COG3956@2|Bacteria,3Y46M@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM MazG family protein	-	-	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HFD2_k127_7236330_13	113395.AXAI01000021_gene3458	5.051e-55	202.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,2U473@28211|Alphaproteobacteria,3JWV8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
HFD2_k127_7236330_5	234267.Acid_5460	3.759e-116	378.0	COG0081@1|root,COG0081@2|Bacteria,3Y2HX@57723|Acidobacteria	57723|Acidobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HFD2_k127_7236330_11	234267.Acid_5459	5.224e-70	241.0	COG0244@1|root,COG0244@2|Bacteria,3Y4N2@57723|Acidobacteria	57723|Acidobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HFD2_k127_7236330_14	234267.Acid_5458	1.401e-54	193.0	COG0222@1|root,COG0222@2|Bacteria,3Y50J@57723|Acidobacteria	57723|Acidobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HFD2_k127_7236330_0	1267535.KB906767_gene4469	0.0	2526.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria,2JIQM@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HFD2_k127_7236330_6	1267535.KB906767_gene4470	9.99e-114	367.0	COG0086@1|root,COG0086@2|Bacteria,3Y2FZ@57723|Acidobacteria,2JIW0@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HFD2_k127_7238278_2	113395.AXAI01000009_gene2488	7.125e-09	58.0	COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria,2TRXW@28211|Alphaproteobacteria,3JW83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_7238278_0	1340493.JNIF01000004_gene47	5.062e-244	758.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_7238278_1	234267.Acid_3236	3.402e-148	477.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_7241971_1	234267.Acid_5065	5.568e-39	149.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria	57723|Acidobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD2_k127_7241971_0	497964.CfE428DRAFT_4416	2.99e-113	380.0	COG3119@1|root,COG3119@2|Bacteria,46U45@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD2_k127_7241971_2	1382303.JPOM01000001_gene2171	9.608e-39	148.0	COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,2U9KN@28211|Alphaproteobacteria,2KHF8@204458|Caulobacterales	204458|Caulobacterales	K	transcription regulator containing HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD2_k127_7241971_3	1509405.GV67_09535	8.944e-30	120.0	COG4680@1|root,COG4680@2|Bacteria,1N036@1224|Proteobacteria,2UHXB@28211|Alphaproteobacteria,4BG3G@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	HigB_toxin, RelE-like toxic component of a toxin-antitoxin system	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
HFD2_k127_7261414_3	234267.Acid_6509	1.111e-54	199.0	2EKZZ@1|root,33EPG@2|Bacteria,3Y5U9@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Lipase_GDSL_2
HFD2_k127_7261414_1	234267.Acid_2483	1.414e-198	625.0	COG0172@1|root,COG0172@2|Bacteria,3Y2UD@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD2_k127_7261414_2	1267535.KB906767_gene608	1.051e-159	512.0	COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria,2JII8@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD2_k127_7261414_0	1267535.KB906767_gene607	8.4e-323	1001.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD2_k127_7261414_4	1382359.JIAL01000001_gene2631	1.259e-29	124.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_7308489_3	1502850.FG91_00611	4.676e-33	135.0	COG0738@1|root,COG0738@2|Bacteria,1R3UK@1224|Proteobacteria,2UAWH@28211|Alphaproteobacteria,2K2HW@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7308489_2	234267.Acid_2215	1.116e-171	550.0	COG0673@1|root,COG0673@2|Bacteria,3Y6W6@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_7308489_0	234267.Acid_2773	2.686e-179	566.0	COG1082@1|root,COG1082@2|Bacteria,3Y3U5@57723|Acidobacteria	57723|Acidobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HFD2_k127_7308489_1	234267.Acid_5413	4.432e-173	551.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,3Y6AS@57723|Acidobacteria	57723|Acidobacteria	CG	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HFD2_k127_7327488_2	671143.DAMO_3153	4.247e-84	284.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	salY	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
HFD2_k127_7327488_0	234267.Acid_4992	7.996e-124	421.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_7327488_1	1267535.KB906767_gene445	8.111e-120	397.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD2_k127_7327488_3	1267535.KB906767_gene446	1.217e-69	245.0	COG1974@1|root,COG1974@2|Bacteria,3Y813@57723|Acidobacteria	57723|Acidobacteria	KT	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7327488_4	234267.Acid_7761	2.004e-41	160.0	2FHZ5@1|root,349S3@2|Bacteria,3Y8GI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7347095_2	234267.Acid_5840	5.712e-106	347.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria	57723|Acidobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_7347095_1	234267.Acid_5841	1.269e-130	427.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HFD2_k127_7347095_3	204669.Acid345_1383	6.434e-105	346.0	2CEY7@1|root,2Z8CG@2|Bacteria,3Y70V@57723|Acidobacteria,2JKPR@204432|Acidobacteriia	204432|Acidobacteriia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7347095_0	204669.Acid345_1384	6.157e-205	640.0	COG1053@1|root,COG1053@2|Bacteria,3Y6IU@57723|Acidobacteria,2JKAD@204432|Acidobacteriia	204432|Acidobacteriia	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_7372842_1	1267535.KB906767_gene1052	6.686e-218	685.0	COG1012@1|root,COG1012@2|Bacteria,3Y3CY@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_7372842_7	1267535.KB906767_gene4197	1.13e-22	104.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_7372842_0	1267535.KB906767_gene1053	3.153e-304	962.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD2_k127_7372842_3	234267.Acid_5064	4.044e-92	310.0	COG1968@1|root,COG1968@2|Bacteria,3Y588@57723|Acidobacteria	57723|Acidobacteria	V	Bacitracin resistance protein BacA	-	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD2_k127_7372842_6	1122222.AXWR01000027_gene232	1.392e-23	102.0	COG4423@1|root,COG4423@2|Bacteria,1WKIR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Rv0623-like transcription factor	-	-	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
HFD2_k127_7372842_4	1297569.MESS2_780003	1.147e-36	142.0	COG3742@1|root,COG3742@2|Bacteria,1N937@1224|Proteobacteria,2UFYN@28211|Alphaproteobacteria,43MAE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K19686	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HFD2_k127_7372842_2	234267.Acid_1491	1.296e-147	480.0	COG1215@1|root,COG1215@2|Bacteria,3Y2WN@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase family group 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HFD2_k127_7372842_5	1123277.KB893239_gene1214	1.009e-24	106.0	COG0627@1|root,COG0627@2|Bacteria,4NIU8@976|Bacteroidetes,47NUH@768503|Cytophagia	976|Bacteroidetes	E	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD2_k127_7388731_0	234267.Acid_3816	0.0	1735.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3Y2JQ@57723|Acidobacteria	57723|Acidobacteria	E	glutamate synthase alpha subunit	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD2_k127_7441079_5	1267535.KB906767_gene3452	2.866e-62	224.0	COG2207@1|root,COG2207@2|Bacteria,3Y34X@57723|Acidobacteria,2JHK9@204432|Acidobacteriia	204432|Acidobacteriia	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD2_k127_7441079_6	234267.Acid_2053	6.391e-52	194.0	COG3637@1|root,COG3637@2|Bacteria,3Y4NQ@57723|Acidobacteria	57723|Acidobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD2_k127_7441079_3	234267.Acid_7493	7.237e-90	314.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_7441079_0	234267.Acid_6472	1.33e-255	797.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria	57723|Acidobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_7441079_8	234267.Acid_1037	1.407e-44	170.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_7441079_4	1267535.KB906767_gene1512	2.587e-66	231.0	COG0500@1|root,COG0500@2|Bacteria,3Y5HU@57723|Acidobacteria	57723|Acidobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7441079_1	234267.Acid_1034	1.88e-229	718.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_7441079_2	1267535.KB906767_gene968	2.12e-136	446.0	COG4591@1|root,COG4591@2|Bacteria,3Y3BU@57723|Acidobacteria,2JIC6@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HFD2_k127_7441079_10	504472.Slin_2196	0.0001651	44.0	COG0500@1|root,COG0500@2|Bacteria,4PNA6@976|Bacteroidetes	976|Bacteroidetes	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7441079_7	1340493.JNIF01000003_gene2601	6.791e-46	169.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,NeuB
HFD2_k127_7441079_9	1340493.JNIF01000003_gene2561	2.465e-06	49.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ccmA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	-	ABC_tran
HFD2_k127_74514_6	1340493.JNIF01000003_gene1961	1.558e-113	387.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
HFD2_k127_74514_10	234267.Acid_4341	1e-88	304.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888,ko:K20948	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_88
HFD2_k127_74514_15	1267535.KB906767_gene562	6.054e-41	155.0	COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria	57723|Acidobacteria	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HFD2_k127_74514_0	234267.Acid_2504	1.853e-219	689.0	COG0165@1|root,COG0165@2|Bacteria,3Y36Y@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HFD2_k127_74514_1	1267535.KB906767_gene4529	4.342e-217	679.0	COG0137@1|root,COG0137@2|Bacteria,3Y4Y9@57723|Acidobacteria,2JJKA@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD2_k127_74514_5	1267535.KB906767_gene4528	9.778e-122	398.0	COG0078@1|root,COG0078@2|Bacteria,3Y4R3@57723|Acidobacteria,2JP1M@204432|Acidobacteriia	204432|Acidobacteriia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_74514_8	234267.Acid_1210	5.134e-100	349.0	COG0666@1|root,COG1657@1|root,COG0666@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amino_oxidase,Ank,Ank_2,Ank_3,Ank_4,Ank_5,PSCyt1,Peptidase_C14,Prenyltrans,SQHop_cyclase_C
HFD2_k127_74514_20	1267535.KB906767_gene4865	2.391e-15	78.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HFD2_k127_74514_7	1340493.JNIF01000003_gene3546	8.893e-106	362.0	COG0628@1|root,COG0628@2|Bacteria,3Y4N5@57723|Acidobacteria	57723|Acidobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_74514_14	234267.Acid_7012	9.504e-43	161.0	COG0816@1|root,COG0816@2|Bacteria,3Y59A@57723|Acidobacteria	57723|Acidobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD2_k127_74514_9	234267.Acid_7013	1.41e-96	325.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD2_k127_74514_16	234267.Acid_0965	4.924e-40	156.0	COG2137@1|root,COG2137@2|Bacteria,3Y4WT@57723|Acidobacteria	57723|Acidobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HFD2_k127_74514_11	1267535.KB906767_gene2795	1.699e-64	226.0	COG1704@1|root,COG1704@2|Bacteria,3Y4QG@57723|Acidobacteria,2JJCD@204432|Acidobacteriia	204432|Acidobacteriia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD2_k127_74514_12	1267535.KB906767_gene2794	2.075e-64	231.0	COG1708@1|root,COG1708@2|Bacteria,3Y7NX@57723|Acidobacteria,2JNB7@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_74514_13	234267.Acid_0973	7.722e-59	214.0	COG1512@1|root,COG1512@2|Bacteria,3Y4JT@57723|Acidobacteria	57723|Acidobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD2_k127_74514_2	234267.Acid_7201	4.742e-167	539.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_74514_3	234267.Acid_7200	4.413e-160	513.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_74514_22	561229.Dd1591_2231	0.0002377	46.0	2EAVJ@1|root,334WZ@2|Bacteria,1NEMG@1224|Proteobacteria,1ST2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_74514_4	234267.Acid_0594	3.45e-152	490.0	COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_7461741_3	204669.Acid345_0263	1.189e-10	67.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_7461741_1	246197.MXAN_2831	4.074e-84	290.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,42PS8@68525|delta/epsilon subdivisions,2WKAJ@28221|Deltaproteobacteria,2YUTN@29|Myxococcales	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_7461741_2	1192034.CAP_4076	3.542e-72	251.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,42PYZ@68525|delta/epsilon subdivisions,2WK4B@28221|Deltaproteobacteria,2YUCX@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050,ko:K15599	ko02010,map02010	M00188,M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.3,3.A.1.17.6	-	-	BPD_transp_1
HFD2_k127_7461741_0	1242864.D187_007806	2.282e-84	286.0	COG1116@1|root,COG1116@2|Bacteria,1P4HB@1224|Proteobacteria,42NNH@68525|delta/epsilon subdivisions,2WUV9@28221|Deltaproteobacteria,2YUPS@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_7461741_4	1340493.JNIF01000003_gene2955	2.136e-05	52.0	2FIG5@1|root,34A8B@2|Bacteria,3Y8GN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7525561_3	1382359.JIAL01000001_gene129	3.768e-203	640.0	COG0488@1|root,COG0488@2|Bacteria,3Y3IA@57723|Acidobacteria,2JI1Y@204432|Acidobacteriia	204432|Acidobacteriia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD2_k127_7525561_4	1232683.ADIMK_3833	4.343e-111	367.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,465X2@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Ank_4,Glutaminase
HFD2_k127_7525561_8	1210884.HG799464_gene10754	1.508e-89	302.0	COG1611@1|root,COG1611@2|Bacteria,2IZCH@203682|Planctomycetes	203682|Planctomycetes	NOU	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD2_k127_7525561_12	472759.Nhal_1885	2.5e-28	119.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,1X1W5@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_7525561_10	234267.Acid_2726	2.286e-83	291.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7525561_5	234267.Acid_5375	1.126e-107	363.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7525561_11	1121943.KB899990_gene3768	3.756e-74	256.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,1SYVW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_7525561_2	234267.Acid_2667	1.403e-244	758.0	COG4948@1|root,COG4948@2|Bacteria,3Y4P2@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_7525561_6	1267535.KB906767_gene2960	9.392e-103	343.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria,2JHIF@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7525561_0	234267.Acid_2666	0.0	1081.0	COG3661@1|root,COG3661@2|Bacteria,3Y2TM@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 67 family	-	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
HFD2_k127_7525561_9	234267.Acid_4025	1.913e-89	304.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	CheW,NMT1,NMT1_2,OmpA,Phosphonate-bd,Response_reg,Sigma70_r2
HFD2_k127_7525561_1	234267.Acid_2557	1.903e-266	834.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_7525561_7	398525.KB900701_gene4497	5.289e-96	322.0	COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2U1E9@28211|Alphaproteobacteria,3JTTY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_7558256_2	234267.Acid_0893	2.479e-66	229.0	COG1337@1|root,COG1337@2|Bacteria,3Y6QK@57723|Acidobacteria	57723|Acidobacteria	L	RAMP superfamily	-	-	-	ko:K09002	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HFD2_k127_7558256_1	1267535.KB906767_gene2607	3.561e-107	356.0	COG1567@1|root,COG1567@2|Bacteria,3Y72B@57723|Acidobacteria	57723|Acidobacteria	L	CRISPR-associated RAMP protein, Csm4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7558256_0	234267.Acid_0895	1.306e-121	405.0	COG1332@1|root,COG1332@2|Bacteria,3Y71E@57723|Acidobacteria	57723|Acidobacteria	L	RAMP superfamily	-	-	-	ko:K19140	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HFD2_k127_7558256_3	1267535.KB906767_gene1027	6.419e-15	74.0	COG3267@1|root,COG3267@2|Bacteria,3Y6KP@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD2_k127_7638384_0	1267535.KB906767_gene2670	3.016e-46	183.0	COG4485@1|root,COG4485@2|Bacteria,3Y74P@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD2_k127_7638384_2	1278073.MYSTI_01276	1.101e-25	111.0	COG3795@1|root,COG3795@2|Bacteria	2|Bacteria	F	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
HFD2_k127_7638384_1	1165096.ARWF01000001_gene440	9.101e-28	121.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2W82N@28216|Betaproteobacteria,2KNHR@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7665448_3	266264.Rmet_6564	0.0004135	46.0	29F37@1|root,3020Z@2|Bacteria,1PIS4@1224|Proteobacteria,2W7BE@28216|Betaproteobacteria,1KE9E@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7665448_0	596154.Alide2_4309	1.647e-115	385.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2VPAP@28216|Betaproteobacteria,4AFM7@80864|Comamonadaceae	28216|Betaproteobacteria	L	Insertion element 4 transposase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
HFD2_k127_7665448_2	68260.JOAY01000006_gene5083	2.145e-14	76.0	COG0433@1|root,COG0433@2|Bacteria,2GX85@201174|Actinobacteria	201174|Actinobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HFD2_k127_7665448_1	234267.Acid_1817	1.87e-35	137.0	COG4206@1|root,COG4206@2|Bacteria,3Y8AK@57723|Acidobacteria	57723|Acidobacteria	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_7696754_0	1267535.KB906767_gene2639	3.359e-119	387.0	COG2404@1|root,COG2404@2|Bacteria,3Y98M@57723|Acidobacteria,2JP53@204432|Acidobacteriia	204432|Acidobacteriia	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7696754_1	1340493.JNIF01000003_gene4008	2.149e-75	267.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3Y4AH@57723|Acidobacteria	57723|Acidobacteria	K	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HFD2_k127_7696754_2	234267.Acid_7804	6.469e-74	258.0	COG2948@1|root,COG2948@2|Bacteria,3Y6SY@57723|Acidobacteria	57723|Acidobacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7696754_3	1267535.KB906767_gene3660	1.768e-72	260.0	28H5M@1|root,2Z7I7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7696754_5	667632.KB890187_gene3066	8.173e-14	79.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VJ3Z@28216|Betaproteobacteria,1KIFW@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_3,PAS_4,Response_reg
HFD2_k127_7696754_4	1158292.JPOE01000005_gene1133	2.154e-64	224.0	COG0707@1|root,COG0707@2|Bacteria,1QU89@1224|Proteobacteria,2VKVF@28216|Betaproteobacteria,1KIY2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferase family 1	-	-	2.4.1.315,2.4.1.46	ko:K03429,ko:K03715	ko00561,ko01100,map00561,map01100	-	R02689,R02691,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HFD2_k127_7704871_0	28072.Nos7524_4754	6.588e-51	184.0	COG0614@1|root,COG0614@2|Bacteria,1G71C@1117|Cyanobacteria,1HP4K@1161|Nostocales	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD2_k127_7704871_2	298653.Franean1_2903	1.473e-41	172.0	COG1321@1|root,COG1321@2|Bacteria,2ICG2@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7721192_5	502025.Hoch_0686	7.296e-116	393.0	COG3203@1|root,COG3203@2|Bacteria,1QVA0@1224|Proteobacteria,42P8X@68525|delta/epsilon subdivisions,2WM47@28221|Deltaproteobacteria,2YXTN@29|Myxococcales	28221|Deltaproteobacteria	M	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,FG-GAP_2
HFD2_k127_7721192_11	234267.Acid_5050	2.065e-64	235.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Big_2,F5_F8_type_C,Glyco_hydro_98C,Glyco_hydro_98M,NPCBM,Peptidase_M16,Peptidase_M16_C
HFD2_k127_7721192_6	1033802.SSPSH_001868	6.638e-115	382.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_7721192_2	266117.Rxyl_1565	2.774e-195	623.0	COG0404@1|root,COG0404@2|Bacteria,2GPU4@201174|Actinobacteria,4CRTT@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM glycine cleavage T protein (aminomethyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
HFD2_k127_7721192_7	1382306.JNIM01000001_gene2426	6.048e-93	317.0	COG0508@1|root,COG0508@2|Bacteria,2G6A9@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_7721192_1	1382306.JNIM01000001_gene2427	3.774e-212	666.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_7721192_3	1382306.JNIM01000001_gene2428	5.588e-160	510.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_7721192_8	266117.Rxyl_3050	2.251e-88	302.0	COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,4CU2B@84995|Rubrobacteria	84995|Rubrobacteria	C	Transketolase, thiamine diphosphate binding domain	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD2_k127_7721192_4	485913.Krac_9361	1.989e-117	384.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_7721192_0	204669.Acid345_0377	1.931e-213	670.0	COG1012@1|root,COG1012@2|Bacteria,3Y2Q5@57723|Acidobacteria,2JIKC@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_7721192_14	523850.TON_0131	2.777e-42	172.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_7721192_13	765952.PUV_08810	1.159e-54	205.0	COG0295@1|root,COG0295@2|Bacteria	2|Bacteria	F	cytidine deaminase activity	cdd	GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	iECO103_1326.ECO103_2618	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HFD2_k127_7721192_12	485918.Cpin_4966	1.494e-55	201.0	COG2318@1|root,COG2318@2|Bacteria,4NP63@976|Bacteroidetes,1ISD5@117747|Sphingobacteriia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_7721192_9	234267.Acid_1203	1.296e-69	242.0	COG1732@1|root,COG1732@2|Bacteria,3Y3Z9@57723|Acidobacteria	57723|Acidobacteria	M	ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HFD2_k127_7726179_1	1267535.KB906767_gene4920	5.773e-29	124.0	COG1629@1|root,COG4771@2|Bacteria,3Y7CC@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_7726179_0	1194165.CAJF01000006_gene2441	3.858e-45	185.0	COG0491@1|root,COG0491@2|Bacteria,2IBAX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7736658_7	1267535.KB906767_gene3339	2.672e-62	218.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria,2JIXA@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_7736658_0	1267535.KB906767_gene3340	1.228e-233	736.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria,2JIPN@204432|Acidobacteriia	204432|Acidobacteriia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HFD2_k127_7736658_1	1267535.KB906767_gene3341	1.8e-136	442.0	COG0451@1|root,COG0451@2|Bacteria,3Y5IZ@57723|Acidobacteria,2JNMW@204432|Acidobacteriia	204432|Acidobacteriia	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_7736658_8	1232410.KI421426_gene1351	4.746e-38	150.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,42UZX@68525|delta/epsilon subdivisions,2WQ98@28221|Deltaproteobacteria,43SMU@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
HFD2_k127_7736658_4	234267.Acid_5987	4.703e-115	387.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_7736658_5	1340493.JNIF01000003_gene2590	2.961e-114	381.0	COG1566@1|root,COG1566@2|Bacteria,3Y53G@57723|Acidobacteria	57723|Acidobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_7736658_6	1340493.JNIF01000003_gene2589	5.361e-104	348.0	COG1131@1|root,COG1131@2|Bacteria,3Y725@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7736658_2	234267.Acid_5990	5.93e-129	420.0	COG1131@1|root,COG1131@2|Bacteria,3Y3VU@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7736658_3	234267.Acid_5991	1.681e-122	410.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_7745761_4	234267.Acid_5302	1.382e-168	543.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	57723|Acidobacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HFD2_k127_7745761_2	234267.Acid_2834	2.338e-186	592.0	COG1236@1|root,COG1236@2|Bacteria,3Y6U0@57723|Acidobacteria	57723|Acidobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HFD2_k127_7745761_5	1267535.KB906767_gene4264	2.556e-114	374.0	COG2013@1|root,COG2013@2|Bacteria,3Y2XF@57723|Acidobacteria,2JIE5@204432|Acidobacteriia	204432|Acidobacteriia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HFD2_k127_7745761_3	1340493.JNIF01000004_gene155	5.382e-181	605.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	CARDB,Calx-beta,CarboxypepD_reg,He_PIG,Laminin_G_3,NHL,SGL
HFD2_k127_7745761_6	234267.Acid_6764	6.218e-92	309.0	COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HFD2_k127_7745761_1	1267535.KB906767_gene4746	6.461e-204	637.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria,2JIBR@204432|Acidobacteriia	204432|Acidobacteriia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HFD2_k127_7745761_7	1128421.JAGA01000003_gene3091	3.427e-27	129.0	COG4485@1|root,COG4485@2|Bacteria,2NP78@2323|unclassified Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD2_k127_7745761_0	1267535.KB906767_gene3391	5.436e-228	714.0	COG0488@1|root,COG0488@2|Bacteria,3Y2H0@57723|Acidobacteria,2JI7S@204432|Acidobacteriia	204432|Acidobacteriia	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD2_k127_7768562_0	485913.Krac_7664	9.146e-198	630.0	COG0318@1|root,COG0318@2|Bacteria,2G5XA@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7768562_2	627192.SLG_23730	1.109e-11	72.0	2FIXR@1|root,34ANN@2|Bacteria,1NNY2@1224|Proteobacteria,2UMAG@28211|Alphaproteobacteria,2K886@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD2_k127_7768562_1	639030.JHVA01000001_gene2618	3.93e-84	286.0	COG2382@1|root,COG2382@2|Bacteria,3Y5EH@57723|Acidobacteria,2JJUH@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD2_k127_7776689_3	234267.Acid_5138	9.076e-31	132.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD2_k127_7776689_0	234267.Acid_3989	7.524e-127	417.0	COG2006@1|root,COG2006@2|Bacteria,3Y6M1@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HFD2_k127_7776689_1	234267.Acid_1913	7.627e-57	203.0	COG4636@1|root,COG4636@2|Bacteria,3Y7WQ@57723|Acidobacteria	57723|Acidobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_7776689_2	234267.Acid_5274	1.197e-55	197.0	COG0192@1|root,COG0192@2|Bacteria,3Y45C@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_7789132_0	1267535.KB906767_gene4512	2.793e-272	855.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7789132_3	457429.ABJI02000446_gene5398	2.256e-36	140.0	COG0748@1|root,COG0748@2|Bacteria,2I5IZ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_7789132_1	1038859.AXAU01000001_gene3393	2.001e-100	336.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U0ZD@28211|Alphaproteobacteria,3JY8Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
HFD2_k127_7789132_2	234267.Acid_1913	9.507e-47	173.0	COG4636@1|root,COG4636@2|Bacteria,3Y7WQ@57723|Acidobacteria	57723|Acidobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_7789132_4	247490.KSU1_C1151	4.08e-11	63.0	COG2318@1|root,COG2318@2|Bacteria,2J1FT@203682|Planctomycetes	203682|Planctomycetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_7813821_1	1089553.Tph_c18080	3.325e-28	123.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,42G5U@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_7813821_0	335283.Neut_1059	1.248e-59	215.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_7836193_7	627192.SLG_31390	1.523e-141	463.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
HFD2_k127_7836193_1	234267.Acid_5827	1.244e-237	758.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_7836193_5	627192.SLG_31400	2.929e-148	482.0	COG2960@1|root,COG2960@2|Bacteria,1RGT9@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HFD2_k127_7836193_13	1335760.ASTG01000003_gene1750	2.6e-23	109.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7836193_12	1405.DJ92_3414	2.154e-56	207.0	COG0491@1|root,COG0491@2|Bacteria,1U974@1239|Firmicutes,4IJ9B@91061|Bacilli,1ZN0N@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7836193_3	234267.Acid_2071	4.846e-165	534.0	COG0738@1|root,COG0738@2|Bacteria,3Y723@57723|Acidobacteria	57723|Acidobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7836193_2	234267.Acid_2070	5.586e-218	691.0	COG0366@1|root,COG0366@2|Bacteria,3Y6H6@57723|Acidobacteria	57723|Acidobacteria	G	Alpha amylase, catalytic domain	-	-	2.4.1.7,3.2.1.1,5.4.99.16	ko:K00690,ko:K05343	ko00500,ko01100,map00500,map01100	-	R00803,R01557,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HFD2_k127_7836193_10	234267.Acid_2069	1.966e-98	331.0	COG0524@1|root,COG0524@2|Bacteria,3Y4R5@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_7836193_4	234267.Acid_2068	8.533e-160	513.0	COG1609@1|root,COG1609@2|Bacteria,3Y2ZZ@57723|Acidobacteria	57723|Acidobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
HFD2_k127_7836193_9	234267.Acid_2089	6.304e-110	363.0	COG2755@1|root,COG2755@2|Bacteria,3Y4BD@57723|Acidobacteria	57723|Acidobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_7836193_0	234267.Acid_2067	0.0	1481.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_7836193_6	234267.Acid_2074	5.773e-143	473.0	COG2755@1|root,COG2755@2|Bacteria,3Y2KK@57723|Acidobacteria	57723|Acidobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_7836193_8	234267.Acid_2073	1.921e-133	435.0	COG0296@1|root,COG2382@1|root,COG0296@2|Bacteria,COG2382@2|Bacteria,3Y6V1@57723|Acidobacteria	57723|Acidobacteria	GP	Belongs to the glycosyl hydrolase 13 family	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD2_k127_7836193_11	1126627.BAWE01000004_gene4302	7.347e-74	256.0	COG0627@1|root,COG0627@2|Bacteria,1MX6W@1224|Proteobacteria,2TSCC@28211|Alphaproteobacteria,3JTMK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tannase and feruloyl esterase	-	-	3.1.1.102	ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	Tannase
HFD2_k127_7847562_10	234267.Acid_1502	1.704e-79	273.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_7847562_8	1267535.KB906767_gene626	2.464e-91	308.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria,2JI3W@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HFD2_k127_7847562_18	1340493.JNIF01000003_gene4333	2.088e-26	115.0	COG3087@1|root,COG3087@2|Bacteria,3Y4WI@57723|Acidobacteria	57723|Acidobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HFD2_k127_7847562_7	234267.Acid_1499	5.15e-110	361.0	COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_7847562_11	696281.Desru_1115	7.189e-70	250.0	2F459@1|root,33WWJ@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_7847562_9	234267.Acid_5860	3.514e-86	307.0	COG1807@1|root,COG1807@2|Bacteria,3Y7PC@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7847562_13	1340493.JNIF01000004_gene826	2.763e-44	166.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_7847562_1	234267.Acid_4698	1.771e-237	749.0	COG0405@1|root,COG0405@2|Bacteria,3Y6KV@57723|Acidobacteria	57723|Acidobacteria	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_7847562_5	234267.Acid_4697	1.049e-112	373.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_7847562_0	240015.ACP_0186	5.511e-262	826.0	COG1643@1|root,COG1643@2|Bacteria,3Y38N@57723|Acidobacteria,2JHKA@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP-dependent helicase HrpB	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HFD2_k127_7847562_3	1267534.KB906755_gene4272	1.02e-142	464.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	AAA_19,Ank,Ank_2,Ank_3,Ank_4,Ank_5,Sigma70_r2,Sigma70_r4,Viral_helicase1
HFD2_k127_7847562_15	234267.Acid_1068	5.993e-42	166.0	COG2264@1|root,COG2264@2|Bacteria,3Y5SG@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HFD2_k127_7847562_2	234267.Acid_4982	1.543e-199	635.0	COG0318@1|root,COG0318@2|Bacteria,3Y68M@57723|Acidobacteria	57723|Acidobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7847562_19	533240.CRC_02125	1.631e-23	110.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
HFD2_k127_7847562_20	1120968.AUBX01000009_gene309	3.905e-23	106.0	COG2010@1|root,COG2010@2|Bacteria,4NSE3@976|Bacteroidetes	976|Bacteroidetes	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HFD2_k127_7847562_17	234267.Acid_1097	3.538e-31	128.0	COG3474@1|root,COG3474@2|Bacteria,3Y5RW@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Haem_bd
HFD2_k127_7847562_4	234267.Acid_1096	1.436e-131	430.0	COG1409@1|root,COG1409@2|Bacteria,3Y3P7@57723|Acidobacteria	57723|Acidobacteria	C	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_7847562_16	1205680.CAKO01000040_gene890	5.187e-37	148.0	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	'TIGRFAM RNA polymerase sigma factor, sigma-70 family'	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_7847562_12	485913.Krac_10225	1.746e-53	197.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_7847562_22	62928.azo0278	1.458e-07	64.0	2EFNF@1|root,339EK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7847562_14	234267.Acid_5658	8.493e-44	177.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7847562_6	234267.Acid_4910	1.095e-111	370.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_7853276_0	1340493.JNIF01000003_gene4687	3.053e-126	417.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria	57723|Acidobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HFD2_k127_7853276_1	234267.Acid_1008	1.461e-105	353.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria	57723|Acidobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_7854239_0	234267.Acid_1060	3.678e-164	539.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N,TPR_8
HFD2_k127_7854239_1	1267535.KB906767_gene845	5.292e-64	222.0	COG0691@1|root,COG0691@2|Bacteria,3Y4CC@57723|Acidobacteria,2JJ48@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HFD2_k127_7854239_2	69395.JQLZ01000005_gene3645	5.303e-64	230.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7854239_3	234267.Acid_1288	6.265e-57	206.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD2_k127_7855209_6	1340493.JNIF01000004_gene878	3.233e-33	132.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,3Y77C@57723|Acidobacteria	57723|Acidobacteria	G	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Peptidase_C14,TPR_2,WD40
HFD2_k127_7855209_5	234267.Acid_5978	8.84e-45	173.0	2EU62@1|root,33MNN@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384
HFD2_k127_7855209_0	196490.AUEZ01000056_gene1011	1.877e-184	582.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2TSD0@28211|Alphaproteobacteria,3JTGD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphofructokinase	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HFD2_k127_7855209_3	234267.Acid_4738	1.834e-80	274.0	COG0500@1|root,COG2226@2|Bacteria,3Y5PC@57723|Acidobacteria	57723|Acidobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_7855209_2	204669.Acid345_1385	3.711e-132	425.0	COG0479@1|root,COG0479@2|Bacteria,3Y70A@57723|Acidobacteria,2JM7N@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HFD2_k127_7855209_1	204669.Acid345_1384	1.188e-178	565.0	COG1053@1|root,COG1053@2|Bacteria,3Y6IU@57723|Acidobacteria,2JKAD@204432|Acidobacteriia	204432|Acidobacteriia	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_7869526_7	717785.HYPMC_1330	1.551e-05	48.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,2TVAP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HFD2_k127_7869526_8	1303518.CCALI_00699	1.565e-05	57.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HFD2_k127_7869526_3	469610.HMPREF0189_00442	9.273e-143	468.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KP92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HFD2_k127_7869526_6	1379858.N508_00221	2.008e-39	163.0	COG1027@1|root,COG1027@2|Bacteria,2GGQ2@200930|Deferribacteres	200930|Deferribacteres	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD2_k127_7869526_1	1366050.N234_35850	2.476e-228	717.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KGZR@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HFD2_k127_7869526_4	742823.HMPREF9465_00299	1.175e-117	382.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HFD2_k127_7869526_0	469610.HMPREF0189_00997	0.0	1009.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_7869526_5	1304883.KI912532_gene2945	1.066e-94	316.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,2VURZ@28216|Betaproteobacteria,2KYHM@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HFD2_k127_7869526_2	204669.Acid345_0452	1.05e-159	516.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	204432|Acidobacteriia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD2_k127_7880869_3	234267.Acid_2386	1.398e-17	86.0	arCOG08211@1|root,2ZBM3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7880869_1	1267535.KB906767_gene630	2.643e-117	381.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria,2JHYU@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_7880869_0	234267.Acid_7720	8.006e-245	764.0	COG0064@1|root,COG0064@2|Bacteria,3Y2TJ@57723|Acidobacteria	57723|Acidobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD2_k127_7880869_2	234267.Acid_3617	2.85e-52	198.0	COG4758@1|root,COG4758@2|Bacteria,3Y7Z2@57723|Acidobacteria	57723|Acidobacteria	S	N-terminal domain of toast_rack, DUF2154	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
HFD2_k127_7892598_6	234267.Acid_6982	1.275e-129	420.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
HFD2_k127_7892598_12	234267.Acid_6981	9.298e-98	324.0	COG0289@1|root,COG0289@2|Bacteria,3Y50R@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DapB family	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HFD2_k127_7892598_3	234267.Acid_6980	1.033e-135	437.0	COG0329@1|root,COG0329@2|Bacteria,3Y3V8@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_7892598_5	1267535.KB906767_gene2122	2.015e-130	422.0	COG2171@1|root,COG2171@2|Bacteria,3Y2Z3@57723|Acidobacteria,2JIDV@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
HFD2_k127_7892598_15	1267534.KB906759_gene1797	2.536e-52	190.0	29DWE@1|root,300UA@2|Bacteria,3Y8Y0@57723|Acidobacteria,2JNQB@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HFD2_k127_7892598_4	234267.Acid_7123	1.537e-132	431.0	COG0438@1|root,COG0438@2|Bacteria,3Y867@57723|Acidobacteria	57723|Acidobacteria	H	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_7892598_8	234267.Acid_7122	5.154e-124	417.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_7122|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7892598_11	234267.Acid_7120	5.475e-101	342.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
HFD2_k127_7892598_9	234267.Acid_7119	5.004e-103	344.0	COG1216@1|root,COG1216@2|Bacteria,3Y7YU@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7892598_7	234267.Acid_3188	6.085e-126	407.0	COG0037@1|root,COG0037@2|Bacteria,3Y548@57723|Acidobacteria	57723|Acidobacteria	D	PP-loop family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HFD2_k127_7892598_19	1267535.KB906767_gene4154	4.141e-42	166.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25
HFD2_k127_7892598_18	1267535.KB906767_gene4155	2.125e-45	174.0	2DPEK@1|root,331S2@2|Bacteria,3Y55A@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7892598_13	234267.Acid_5827	1.165e-85	300.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	PSCyt1,PSCyt3,PSD2,PSD3,PSD4,PSD5,zf-C4_Topoisom
HFD2_k127_7892598_14	404589.Anae109_0598	2.643e-69	239.0	COG0406@1|root,COG0406@2|Bacteria,1RCJE@1224|Proteobacteria,42W6J@68525|delta/epsilon subdivisions,2WSAJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_7892598_10	1267535.KB906767_gene4765	6.041e-102	337.0	COG1119@1|root,COG1119@2|Bacteria,3Y2Z4@57723|Acidobacteria,2JHX4@204432|Acidobacteriia	204432|Acidobacteriia	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_7892598_1	234267.Acid_2373	4.853e-172	552.0	COG2010@1|root,COG2010@2|Bacteria,3Y9A6@57723|Acidobacteria	2|Bacteria	C	PFAM SMP-30 Gluconolaconase	peaA	-	1.4.9.1	ko:K08685	ko00680,ko01120,map00680,map01120	-	R00606	RC00189	ko00000,ko00001,ko01000	-	-	-	Cu2_monoox_C,Cu2_monooxygen,Cytochrome_CBB3,Dehyd-heme_bind,Qn_am_d_aII,Qn_am_d_aIII,Qn_am_d_aIV
HFD2_k127_7892598_16	234267.Acid_2372	5.974e-47	175.0	COG1225@1|root,COG1225@2|Bacteria,3Y8EY@57723|Acidobacteria	57723|Acidobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_7892598_0	1267535.KB906767_gene2802	0.0	1040.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia	204432|Acidobacteriia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD2_k127_7892598_2	1340493.JNIF01000003_gene2440	5.072e-151	486.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_7892598_17	234267.Acid_7482	1.916e-45	168.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria	57723|Acidobacteria	K	PFAM regulatory protein, MerR	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HFD2_k127_7904529_1	1382359.JIAL01000001_gene163	4.009e-62	217.0	COG0282@1|root,COG0282@2|Bacteria,3Y3Y4@57723|Acidobacteria,2JI6D@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HFD2_k127_7904529_2	1267535.KB906767_gene5452	1.574e-54	195.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N,SLH
HFD2_k127_7904529_0	234267.Acid_3976	4.031e-247	794.0	COG4934@1|root,COG4934@2|Bacteria,3Y37M@57723|Acidobacteria	57723|Acidobacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Pro-kuma_activ
HFD2_k127_7909834_9	1267535.KB906767_gene4740	1.475e-32	130.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_7909834_3	1267535.KB906767_gene4741	2.981e-109	357.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria,2JI9T@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HFD2_k127_7909834_7	1267535.KB906767_gene4742	1.173e-49	181.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria,2JJKY@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD2_k127_7909834_6	234267.Acid_1283	1.777e-50	183.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria	57723|Acidobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD2_k127_7909834_5	1340493.JNIF01000003_gene1845	2.624e-79	276.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HFD2_k127_7909834_0	234267.Acid_1285	0.0	1052.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria	57723|Acidobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_7909834_8	234267.Acid_1286	1.405e-47	174.0	COG3536@1|root,COG3536@2|Bacteria,3Y4UI@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HFD2_k127_7909834_1	1267535.KB906767_gene1158	1.467e-202	637.0	COG0044@1|root,COG0044@2|Bacteria,3Y34R@57723|Acidobacteria,2JIA3@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_7909834_2	234267.Acid_5512	2.908e-146	468.0	COG0540@1|root,COG0540@2|Bacteria,3Y3KK@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_7909834_4	234267.Acid_5511	9.899e-90	298.0	COG2065@1|root,COG2065@2|Bacteria,3Y2S1@57723|Acidobacteria	57723|Acidobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD2_k127_7909834_11	234267.Acid_0533	1.3e-18	91.0	290CR@1|root,2ZN27@2|Bacteria,3Y8Z2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7909834_10	234267.Acid_2867	1.059e-24	106.0	2EIAS@1|root,33C26@2|Bacteria,3Y5X7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7910459_0	234267.Acid_1100	1.056e-132	428.0	COG1696@1|root,COG1696@2|Bacteria,3Y4S9@57723|Acidobacteria	57723|Acidobacteria	M	PFAM membrane bound O-acyl transferase MBOAT	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HFD2_k127_7910459_3	1382359.JIAL01000001_gene804	2.127e-78	268.0	COG1136@1|root,COG1136@2|Bacteria,3Y3JD@57723|Acidobacteria,2JIHH@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7910459_1	401053.AciPR4_2723	4.064e-105	352.0	COG4591@1|root,COG4591@2|Bacteria,3Y3DS@57723|Acidobacteria,2JHS5@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7921098_1	234267.Acid_4601	1.648e-148	475.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD2_k127_7921098_2	234267.Acid_4600	7.183e-131	435.0	COG1807@1|root,COG1807@2|Bacteria,3Y3BJ@57723|Acidobacteria	57723|Acidobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_7921098_4	234267.Acid_4598	3.993e-93	312.0	COG0253@1|root,COG0253@2|Bacteria,3Y4EC@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD2_k127_7921098_0	234267.Acid_4597	1.012e-215	676.0	COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_7921098_3	1278073.MYSTI_01725	1.033e-106	354.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
HFD2_k127_7921098_5	886293.Sinac_1473	1.154e-85	295.0	COG0842@1|root,COG0842@2|Bacteria,2IY6D@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HFD2_k127_7921098_6	1125863.JAFN01000001_gene2568	4.404e-06	50.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	peptidyl-prolyl isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_7943029_3	555793.WSK_4047	2.109e-21	96.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7943029_1	136993.KB900627_gene392	4.174e-38	154.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7943029_2	136993.KB900627_gene392	7.289e-25	117.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,2VG09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7943029_0	234267.Acid_6607	3.83e-145	467.0	COG1529@1|root,COG1529@2|Bacteria,3Y35Q@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_7957958_6	1267535.KB906767_gene5362	1.981e-27	119.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_7957958_4	1267535.KB906767_gene5362	6.217e-37	148.0	COG0526@1|root,COG0526@2|Bacteria,3Y8DU@57723|Acidobacteria	57723|Acidobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_7957958_2	1267535.KB906767_gene5293	1.188e-155	499.0	COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria	57723|Acidobacteria	O	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
HFD2_k127_7957958_0	234267.Acid_4756	0.0	1182.0	COG0013@1|root,COG0013@2|Bacteria,3Y359@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD2_k127_7957958_3	1123368.AUIS01000033_gene1370	1.473e-99	330.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria	1224|Proteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7957958_5	1125863.JAFN01000001_gene2334	1.304e-35	139.0	COG3744@1|root,COG3744@2|Bacteria,1RJ4K@1224|Proteobacteria,42WUI@68525|delta/epsilon subdivisions,2WT5M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_7957958_7	1125863.JAFN01000001_gene2333	1.718e-21	95.0	COG2161@1|root,COG2161@2|Bacteria,1R2Q0@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_7957958_1	1340493.JNIF01000003_gene3558	8.208e-200	625.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HFD2_k127_7981949_3	1242864.D187_006772	7.852e-94	317.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,43777@68525|delta/epsilon subdivisions,2X9UJ@28221|Deltaproteobacteria,2Z0XS@29|Myxococcales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
HFD2_k127_7981949_2	234267.Acid_7506	3.716e-125	408.0	COG1171@1|root,COG1171@2|Bacteria,3Y6Q8@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_7981949_0	278963.ATWD01000001_gene4210	2.339e-157	512.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_7981949_1	278963.ATWD01000001_gene4210	9.71e-141	465.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_7981949_7	589873.EP13_13630	7.798e-06	59.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7981949_4	1279017.AQYJ01000028_gene2525	2.034e-47	190.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7981949_6	471854.Dfer_0291	4.044e-10	68.0	COG1082@1|root,COG1082@2|Bacteria,4NEUS@976|Bacteroidetes,47NHQ@768503|Cytophagia	976|Bacteroidetes	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_7982309_1	443152.MDG893_15260	1.952e-23	107.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_7982397_0	1267535.KB906767_gene199	7.795e-223	694.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_7982397_4	1267535.KB906767_gene200	9.947e-53	190.0	COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_7982397_1	1267535.KB906767_gene5433	3.318e-96	322.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD2_k127_7982397_3	264732.Moth_0141	1.447e-81	282.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42F66@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD2_k127_7982397_2	1340493.JNIF01000004_gene110	1.955e-82	284.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	ydiY	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF3078,DUF481
HFD2_k127_7989183_8	234267.Acid_2370	7.83e-21	93.0	COG0687@1|root,COG0687@2|Bacteria,3Y5JD@57723|Acidobacteria	57723|Acidobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
HFD2_k127_7989183_5	1340493.JNIF01000003_gene3917	5.864e-75	260.0	COG1624@1|root,COG1624@2|Bacteria,3Y7NU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
HFD2_k127_7989183_9	401526.TcarDRAFT_1046	1.775e-07	60.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,4H93V@909932|Negativicutes	909932|Negativicutes	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HFD2_k127_7989183_2	234267.Acid_1911	2.097e-157	514.0	COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_7989183_3	234267.Acid_1080	6.789e-125	411.0	COG0477@1|root,COG2814@2|Bacteria,3Y2XP@57723|Acidobacteria	57723|Acidobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7989183_0	1267535.KB906767_gene2414	8.752e-304	938.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria,2JI90@204432|Acidobacteriia	204432|Acidobacteriia	EH	Acetolactate synthase, large subunit	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_7989183_6	234267.Acid_0179	4.703e-68	237.0	COG0440@1|root,COG0440@2|Bacteria,3Y580@57723|Acidobacteria	57723|Acidobacteria	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HFD2_k127_7989183_1	234267.Acid_0178	4.418e-169	535.0	COG0059@1|root,COG0059@2|Bacteria,3Y34M@57723|Acidobacteria	57723|Acidobacteria	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HFD2_k127_7989183_4	1267535.KB906767_gene207	3.428e-91	303.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria,2JI0S@204432|Acidobacteriia	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD2_k127_7991477_27	234267.Acid_3846	1.286e-31	128.0	2FCIR@1|root,344N3@2|Bacteria,3Y8MF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_23	234267.Acid_3847	1.672e-43	166.0	COG1434@1|root,COG1434@2|Bacteria,3Y8M4@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD2_k127_7991477_22	1429916.X566_21020	2.661e-54	199.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_7991477_5	234267.Acid_7856	2.593e-186	593.0	COG0305@1|root,COG0305@2|Bacteria,3Y335@57723|Acidobacteria	57723|Acidobacteria	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD2_k127_7991477_30	43989.cce_1835	9.646e-20	90.0	COG1598@1|root,COG1598@2|Bacteria,1G9PW@1117|Cyanobacteria	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD2_k127_7991477_32	345341.KUTG_07962	3.935e-17	82.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HFD2_k127_7991477_11	234267.Acid_0083	1.731e-97	330.0	COG1502@1|root,COG1502@2|Bacteria,3Y5UA@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD2_k127_7991477_16	1340493.JNIF01000003_gene2546	1.635e-78	274.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_24	1267535.KB906767_gene774	2.59e-40	159.0	2DP3Z@1|root,342RZ@2|Bacteria,3Y891@57723|Acidobacteria,2JNCK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_26	234267.Acid_0082	4.18e-35	145.0	2FE51@1|root,3464Y@2|Bacteria,3Y8E0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_10	234267.Acid_0081	1.096e-107	357.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_7991477_25	627192.SLG_25140	1.639e-37	153.0	2EVK9@1|root,33P0C@2|Bacteria,1NDYB@1224|Proteobacteria,2UQHZ@28211|Alphaproteobacteria,2K9N4@204457|Sphingomonadales	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_28	926560.KE387023_gene1140	1.247e-29	130.0	COG2318@1|root,COG2318@2|Bacteria,1WMTV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_7991477_9	234267.Acid_4552	1.016e-114	378.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_7991477_12	1340493.JNIF01000003_gene3709	5.514e-95	316.0	COG0681@1|root,COG0681@2|Bacteria,3Y40D@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_7991477_7	234267.Acid_4553	1.882e-159	509.0	COG0836@1|root,COG0836@2|Bacteria,3Y2W2@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD2_k127_7991477_4	1267535.KB906767_gene801	7.466e-194	614.0	COG4992@1|root,COG4992@2|Bacteria,3Y36P@57723|Acidobacteria,2JISH@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_7991477_14	234267.Acid_2205	9.854e-81	274.0	COG0274@1|root,COG0274@2|Bacteria,3Y2Q4@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_7991477_2	1267535.KB906767_gene2157	1.41e-225	717.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
HFD2_k127_7991477_6	234267.Acid_2187	8.756e-162	522.0	COG0019@1|root,COG0019@2|Bacteria,3Y2W4@57723|Acidobacteria	57723|Acidobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD2_k127_7991477_21	1267535.KB906767_gene664	1.071e-54	207.0	COG1082@1|root,COG1082@2|Bacteria,3Y4SF@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl-hydrolase 97 N-terminal	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
HFD2_k127_7991477_1	1340493.JNIF01000004_gene24	1.601e-280	881.0	COG1529@1|root,COG1529@2|Bacteria,3Y77V@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_7991477_19	861299.J421_2167	1.007e-66	230.0	COG2080@1|root,COG2080@2|Bacteria,1ZTHW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_7991477_20	234267.Acid_0293	6.709e-57	214.0	COG0251@1|root,COG0251@2|Bacteria,3Y810@57723|Acidobacteria	57723|Acidobacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7991477_15	1340493.JNIF01000003_gene1683	3.488e-80	284.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	CsgG,FlgT_C
HFD2_k127_7991477_18	1340493.JNIF01000003_gene1683	1.586e-75	264.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	CsgG,FlgT_C
HFD2_k127_7991477_0	1267535.KB906767_gene4309	0.0	1161.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria,2JHTC@204432|Acidobacteriia	204432|Acidobacteriia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD2_k127_7991477_8	1267535.KB906767_gene4310	2.823e-125	411.0	COG2377@1|root,COG2377@2|Bacteria,3Y3CU@57723|Acidobacteria,2JI1E@204432|Acidobacteriia	204432|Acidobacteriia	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
HFD2_k127_7991477_3	234267.Acid_7220	1.972e-202	638.0	COG2010@1|root,COG2010@2|Bacteria,3Y650@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3,Paired_CXXCH_1
HFD2_k127_7991477_17	1340493.JNIF01000004_gene761	2.456e-78	271.0	COG1858@1|root,COG1858@2|Bacteria,3Y46D@57723|Acidobacteria	57723|Acidobacteria	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD2_k127_7991477_31	290397.Adeh_2899	3.328e-19	103.0	COG0823@1|root,COG0823@2|Bacteria,1NKG5@1224|Proteobacteria	1224|Proteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_7991477_13	1047013.AQSP01000125_gene2637	7.259e-82	299.0	COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N
HFD2_k127_7991477_33	1267533.KB906740_gene287	5.846e-14	86.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF4214,SBBP,TPR_19
HFD2_k127_7991477_29	204669.Acid345_4155	9.099e-20	104.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HFD2_k127_7991477_34	861299.J421_5899	4.086e-06	60.0	COG0457@1|root,COG0823@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K03641,ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02000	2.C.1.2	-	-	DUF4214,Pkinase,SBBP,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_7999509_1	326424.FRAAL4637	2.15e-15	79.0	COG0662@1|root,COG0662@2|Bacteria,2IN75@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_7999509_0	391625.PPSIR1_16130	1.394e-140	462.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HFD2_k127_8008142_0	234267.Acid_5485	0.0	1285.0	COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_8008142_3	1267535.KB906767_gene5351	3.027e-121	402.0	COG0845@1|root,COG0845@2|Bacteria,3Y3C9@57723|Acidobacteria,2JIN9@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_8008142_2	234267.Acid_5483	1.782e-131	432.0	COG1538@1|root,COG1538@2|Bacteria,3Y3PX@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_8008142_8	643648.Slip_1328	4.283e-08	64.0	COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,24D4Q@186801|Clostridia	186801|Clostridia	P	TIGRFAM ABC transporter, substrate-binding protein, aliphatic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,OmpA
HFD2_k127_8008142_4	264198.Reut_B5775	2.154e-107	357.0	COG3384@1|root,COG3384@2|Bacteria,1R6R4@1224|Proteobacteria,2W1RP@28216|Betaproteobacteria,1K5YM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15065	ko00627,ko01120,map00627,map01120	-	R09272	RC01369	ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_8008142_5	1280954.HPO_17355	4.197e-99	337.0	COG2159@1|root,COG2159@2|Bacteria,1PZ2R@1224|Proteobacteria,2VCU2@28211|Alphaproteobacteria,43ZVK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_8008142_6	335543.Sfum_2623	1.963e-83	282.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,42SKW@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	ThiJ PfpI	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD2_k127_8008142_7	264198.Reut_C5931	7.499e-36	151.0	COG0251@1|root,COG0251@2|Bacteria,1RB9R@1224|Proteobacteria,2VRZG@28216|Betaproteobacteria,1K81G@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_8008142_1	1121861.KB899916_gene1772	5.962e-145	479.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD2_k127_8057318_4	1267535.KB906767_gene2807	1.314e-76	288.0	COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_8057318_1	234267.Acid_3567	5.06e-106	352.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD2_k127_8057318_2	234267.Acid_2837	6.606e-92	314.0	COG0823@1|root,COG0823@2|Bacteria,3Y89F@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	PD40
HFD2_k127_8057318_6	234267.Acid_6742	3.105e-39	154.0	2DYK5@1|root,34A5U@2|Bacteria,3Y8GF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_2
HFD2_k127_8057318_3	1379698.RBG1_1C00001G1799	1.701e-87	294.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HFD2_k127_8057318_0	234267.Acid_6443	0.0	1368.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_8057318_5	1340493.JNIF01000003_gene1447	9.813e-51	183.0	COG1194@1|root,COG1194@2|Bacteria,3Y50Y@57723|Acidobacteria	57723|Acidobacteria	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HFD2_k127_808121_0	234267.Acid_3236	2.527e-263	827.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_808121_2	234267.Acid_0259	1.676e-145	467.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_808121_3	234267.Acid_0257	1.842e-123	401.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	gbpD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,Peptidase_S9
HFD2_k127_8088775_0	1267533.KB906737_gene1685	1.374e-57	207.0	COG1595@1|root,COG1595@2|Bacteria,3Y7S5@57723|Acidobacteria,2JMWY@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_8088775_1	710687.KI912270_gene3245	7.861e-35	137.0	2BVXR@1|root,32IG2@2|Bacteria,2IMT1@201174|Actinobacteria,238R3@1762|Mycobacteriaceae	201174|Actinobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD2_k127_8088775_2	1267535.KB906767_gene4305	4.534e-15	79.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DHOR
HFD2_k127_8106832_16	1396858.Q666_06985	1.99e-42	159.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,467FG@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_8106832_6	234267.Acid_5924	2.537e-120	409.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	NHL
HFD2_k127_8106832_0	1267535.KB906767_gene5100	0.0	1059.0	COG1166@1|root,COG1166@2|Bacteria,3Y449@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HFD2_k127_8106832_4	1192034.CAP_7374	4.65e-125	422.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,437F0@68525|delta/epsilon subdivisions,2XA2R@28221|Deltaproteobacteria,2YTSS@29|Myxococcales	28221|Deltaproteobacteria	E	ERAP1-like C-terminal domain	-	-	3.4.11.14	ko:K01263	-	-	-	-	ko00000,ko01000	-	-	-	ERAP1_C,Peptidase_M1
HFD2_k127_8106832_9	234267.Acid_2127	2.646e-93	316.0	COG4447@1|root,COG4447@2|Bacteria,3Y2XZ@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8106832_1	1183438.GKIL_0441	1.361e-242	767.0	COG1770@1|root,COG1770@2|Bacteria,1G1RH@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_8106832_18	1267535.KB906767_gene2546	3.752e-38	144.0	2E8MJ@1|root,32S5J@2|Bacteria,3Y53W@57723|Acidobacteria,2JNZ2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
HFD2_k127_8106832_5	1267535.KB906767_gene2547	8.301e-122	407.0	COG1807@1|root,COG1807@2|Bacteria,3Y2UV@57723|Acidobacteria,2JIS6@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_8106832_10	1379270.AUXF01000007_gene1057	4.081e-90	311.0	COG3174@1|root,COG3174@2|Bacteria,1ZUTX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HFD2_k127_8106832_15	1340493.JNIF01000003_gene2516	1.274e-58	221.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_8106832_2	1267535.KB906767_gene3449	4.277e-150	481.0	COG1494@1|root,COG1494@2|Bacteria,3Y2XJ@57723|Acidobacteria,2JKWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HFD2_k127_8106832_11	234267.Acid_7366	1.121e-79	273.0	2D61V@1|root,32TKB@2|Bacteria,3Y5CF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8106832_13	1267535.KB906767_gene4950	5.233e-68	243.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_8106832_17	1340493.JNIF01000003_gene2955	1.205e-39	150.0	2FIG5@1|root,34A8B@2|Bacteria,3Y8GN@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8106832_8	234267.Acid_0454	2.864e-99	332.0	COG1269@1|root,COG1269@2|Bacteria,3Y62W@57723|Acidobacteria	57723|Acidobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HFD2_k127_8106832_14	234267.Acid_0455	6.015e-61	218.0	COG1269@1|root,COG1269@2|Bacteria,3Y7S1@57723|Acidobacteria	57723|Acidobacteria	C	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485
HFD2_k127_8106832_20	1340493.JNIF01000004_gene174	1.408e-17	90.0	2DTNA@1|root,33M1Q@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2809)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2809
HFD2_k127_8106832_12	234267.Acid_6304	7.161e-74	254.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_8106832_3	1267535.KB906767_gene4617	1.543e-148	484.0	COG2262@1|root,COG2262@2|Bacteria,3Y2FK@57723|Acidobacteria,2JI0F@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD2_k127_8106832_19	1267535.KB906767_gene4616	8.589e-33	132.0	COG1923@1|root,COG1923@2|Bacteria,3Y59T@57723|Acidobacteria	57723|Acidobacteria	S	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HFD2_k127_8106832_7	234267.Acid_6674	2.381e-118	387.0	COG0535@1|root,COG0535@2|Bacteria,3Y5QY@57723|Acidobacteria	57723|Acidobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HFD2_k127_8139622_2	1267535.KB906767_gene1620	4.232e-07	51.0	COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_8139622_0	234267.Acid_0751	2.43e-300	941.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_8139622_1	204669.Acid345_0263	6.385e-21	96.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_8149289_4	234267.Acid_1306	8.357e-34	147.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_8149289_1	1123060.JONP01000001_gene1621	1.611e-64	228.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,2JR9J@204441|Rhodospirillales	28211|Alphaproteobacteria	Q	protocatechuate 3,4-dioxygenase, beta subunit	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HFD2_k127_8149289_2	1121106.JQKB01000041_gene1554	4.351e-49	181.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2TTZJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protocatechuate 3,4-dioxygenase	MA20_23280	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HFD2_k127_8149289_0	1424334.W822_07635	1.855e-110	377.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2,PQQ_3
HFD2_k127_8149289_3	234267.Acid_7538	8.779e-41	156.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase_3
HFD2_k127_8223310_1	234267.Acid_2500	1.814e-113	373.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3Y4I2@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HFD2_k127_8223310_0	1267535.KB906767_gene3621	1.236e-160	523.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria,2JKER@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
HFD2_k127_8223310_3	234267.Acid_4096	7.332e-41	158.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_8223310_2	1267535.KB906767_gene5125	8.438e-54	201.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8230293_4	1267535.KB906767_gene1500	4.568e-57	210.0	COG1732@1|root,COG1732@2|Bacteria,3Y3Z9@57723|Acidobacteria,2JIDY@204432|Acidobacteriia	204432|Acidobacteriia	M	ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HFD2_k127_8230293_0	1380394.JADL01000008_gene3476	0.0	1712.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q44M@1224|Proteobacteria,2V6EC@28211|Alphaproteobacteria,2JQ16@204441|Rhodospirillales	204441|Rhodospirillales	CEH	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HFD2_k127_8230293_1	234267.Acid_1661	1.201e-225	709.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_8230293_2	234267.Acid_1660	6.274e-175	556.0	COG0075@1|root,COG0075@2|Bacteria,3Y3I6@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_8230293_5	1267535.KB906767_gene2672	4.163e-49	179.0	COG1610@1|root,COG1610@2|Bacteria,3Y4VF@57723|Acidobacteria,2JJJH@204432|Acidobacteriia	204432|Acidobacteriia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HFD2_k127_8230293_6	391625.PPSIR1_22951	5.505e-06	56.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,439XM@68525|delta/epsilon subdivisions,2X1UY@28221|Deltaproteobacteria,2Z0MH@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_8230293_3	234267.Acid_7890	2.954e-89	301.0	COG0134@1|root,COG0134@2|Bacteria,3Y3TH@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HFD2_k127_8235014_1	204669.Acid345_0127	2.325e-107	353.0	COG0075@1|root,COG0075@2|Bacteria,3Y2Q8@57723|Acidobacteria,2JKUD@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_8235014_2	1340493.JNIF01000003_gene1505	4.536e-90	308.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8235014_0	1340493.JNIF01000003_gene1504	6.846e-141	453.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8235014_3	1340493.JNIF01000003_gene1503	4.234e-64	226.0	COG1277@1|root,COG1277@2|Bacteria,3Y839@57723|Acidobacteria	57723|Acidobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HFD2_k127_8255493_2	1266925.JHVX01000011_gene1447	1.169e-12	75.0	COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,371T9@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Asparagine synthase	asnB2	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_8255493_1	1131553.JIBI01000003_gene1707	1.425e-19	97.0	COG0500@1|root,COG2226@2|Bacteria,1Q73B@1224|Proteobacteria,2W6KU@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_8255493_0	1304275.C41B8_07477	4.657e-67	244.0	COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,1RN11@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4
HFD2_k127_8255493_3	314278.NB231_08182	2.043e-08	58.0	COG5653@1|root,COG5653@2|Bacteria,1NCB6@1224|Proteobacteria	1224|Proteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HFD2_k127_8256142_3	555793.WSK_4047	1.692e-25	109.0	28NHI@1|root,2ZBJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8256142_1	715451.ambt_12010	1.361e-66	242.0	2CBAE@1|root,31814@2|Bacteria,1R3F3@1224|Proteobacteria,1T675@1236|Gammaproteobacteria,46DFK@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8256142_2	247633.GP2143_17801	3.02e-37	145.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8256142_0	247633.GP2143_17791	2.79e-69	242.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8317806_1	234267.Acid_0505	4.045e-171	544.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria	57723|Acidobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_8317806_0	472759.Nhal_1379	7.782e-292	915.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD2_k127_8317806_4	1380370.JIBA01000017_gene2922	3.701e-18	92.0	2FJ66@1|root,34AWA@2|Bacteria,2H9MS@201174|Actinobacteria,4FJGM@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8317806_6	861299.J421_0887	3.286e-06	52.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_8317806_3	234267.Acid_2615	1.069e-31	133.0	COG4796@1|root,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
HFD2_k127_8317806_2	1121015.N789_09575	4.789e-74	259.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1X6Z0@135614|Xanthomonadales	135614|Xanthomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_8317806_5	234267.Acid_3725	5.781e-15	74.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_8333408_0	543632.JOJL01000113_gene8438	1.153e-199	636.0	COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8333408_1	1340493.JNIF01000003_gene3924	2.283e-15	78.0	2935G@1|root,2ZQNI@2|Bacteria,3Y4NZ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8338726_1	1267535.KB906767_gene606	1.191e-43	174.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HFD2_k127_8338726_0	1267535.KB906767_gene977	1.042e-209	666.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_8338726_2	1267535.KB906767_gene978	9.624e-23	105.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria,2JIHT@204432|Acidobacteriia	204432|Acidobacteriia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
HFD2_k127_8359647_1	1340493.JNIF01000004_gene603	3.297e-150	488.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3Y3AX@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7
HFD2_k127_8359647_2	1340493.JNIF01000004_gene885	5.384e-117	379.0	COG0745@1|root,COG0745@2|Bacteria	1340493.JNIF01000004_gene885|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8359647_0	234267.Acid_4184	0.0	1114.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria	57723|Acidobacteria	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HFD2_k127_8418987_7	1267535.KB906767_gene907	9.559e-84	290.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_16,TPR_19,TPR_8
HFD2_k127_8418987_4	234267.Acid_6437	3.451e-89	304.0	COG4249@1|root,COG4249@2|Bacteria,3Y6DQ@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD2_k127_8418987_0	1267535.KB906767_gene905	2.375e-267	843.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6YC@57723|Acidobacteria	57723|Acidobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HFD2_k127_8418987_5	1267535.KB906767_gene904	5.234e-87	297.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_8418987_9	1267535.KB906767_gene904	4.567e-78	269.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_8418987_8	1267535.KB906767_gene904	1.286e-78	271.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_8418987_1	1267535.KB906767_gene904	7.874e-108	355.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_8418987_10	1267535.KB906767_gene457	7.915e-28	126.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8418987_3	1267535.KB906767_gene904	6.792e-98	327.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_8418987_2	234267.Acid_1438	1.926e-107	367.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_8418987_6	234267.Acid_1454	8.628e-85	290.0	COG1651@1|root,COG1651@2|Bacteria,3Y2G9@57723|Acidobacteria	57723|Acidobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DsbC_N,Thioredoxin_4
HFD2_k127_8418987_11	234267.Acid_1455	1.221e-14	76.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
HFD2_k127_8423169_2	1340493.JNIF01000004_gene855	3.374e-83	287.0	COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_8423169_1	1340493.JNIF01000004_gene856	6.462e-88	296.0	COG0745@1|root,COG0745@2|Bacteria	1340493.JNIF01000004_gene856|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8423169_3	1173024.KI912149_gene4995	7.471e-56	214.0	2EYY5@1|root,33S4X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8423169_0	234267.Acid_4938	1.033e-100	333.0	COG2043@1|root,COG2043@2|Bacteria,3Y6QC@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HFD2_k127_8445715_0	1234364.AMSF01000088_gene2733	1.396e-291	902.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X37B@135614|Xanthomonadales	135614|Xanthomonadales	G	PQQ-like domain	mxaF	-	-	-	-	-	-	-	-	-	-	-	PQQ
HFD2_k127_8445715_1	251221.35211983	2.195e-67	241.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_8453528_0	926569.ANT_21040	7.459e-135	444.0	COG0297@1|root,COG0297@2|Bacteria,2G60C@200795|Chloroflexi	200795|Chloroflexi	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD2_k127_8453528_1	1382356.JQMP01000004_gene276	3.921e-123	406.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi,27XFC@189775|Thermomicrobia	189775|Thermomicrobia	H	Nucleotidyl transferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HFD2_k127_8480662_6	1126627.BAWE01000003_gene1667	8.421e-41	160.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,3JQU4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NHL repeat	MA20_20600	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_8480662_3	234267.Acid_0123	7.793e-92	305.0	COG2096@1|root,COG2096@2|Bacteria,3Y77H@57723|Acidobacteria	57723|Acidobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HFD2_k127_8480662_5	1042375.AFPL01000055_gene2308	2.377e-44	176.0	COG0730@1|root,COG0730@2|Bacteria,1R712@1224|Proteobacteria,1S6UI@1236|Gammaproteobacteria,46CUX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_8480662_4	234267.Acid_2465	5.268e-50	187.0	2C730@1|root,32UQY@2|Bacteria,3Y59Z@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8480662_7	1340493.JNIF01000003_gene2494	1.075e-39	160.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13040	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,NMT1,SBP_bac_3
HFD2_k127_8480662_0	234267.Acid_7333	2.652e-159	513.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD2_k127_8480662_2	1340493.JNIF01000004_gene905	1.977e-125	411.0	COG3437@1|root,COG3437@2|Bacteria,3Y6BB@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD_5,Response_reg
HFD2_k127_8480662_1	234267.Acid_5165	5.554e-143	459.0	COG1064@1|root,COG1064@2|Bacteria,3Y34K@57723|Acidobacteria	57723|Acidobacteria	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD2_k127_8480662_8	1267535.KB906767_gene2141	2.038e-32	127.0	2CBEB@1|root,32STF@2|Bacteria,3Y5AC@57723|Acidobacteria,2JJNZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8480662_9	298655.KI912266_gene1935	7.91e-18	93.0	COG1216@1|root,COG4123@1|root,COG1216@2|Bacteria,COG4123@2|Bacteria,2GKTW@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HFD2_k127_8480662_10	234267.Acid_0642	3.847e-09	60.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM9_1,CHB_HEX_C_1,CarboxypepD_reg,DUF11,Kelch_1,NPCBM_assoc,OmpA,Pectate_lyase_3,SLH,VCBS
HFD2_k127_8487466_4	1122197.ATWI01000011_gene426	1.451e-41	153.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,467FG@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_8487466_2	234267.Acid_1306	1.576e-107	390.0	COG1629@1|root,COG1629@2|Bacteria,3Y99U@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_8487466_6	177437.HRM2_06090	1.637e-22	105.0	COG4195@1|root,COG4195@2|Bacteria,1MZZB@1224|Proteobacteria,42U90@68525|delta/epsilon subdivisions,2WQGX@28221|Deltaproteobacteria,2MKFP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Poly-gamma-glutamate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Gamma_PGA_hydro
HFD2_k127_8487466_3	1340493.JNIF01000003_gene4631	3.45e-82	279.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_8487466_7	401053.AciPR4_0433	6.564e-19	100.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria,2JJYY@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD2_k127_8487466_9	234267.Acid_6303	2.323e-15	89.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria	57723|Acidobacteria	S	Helix-turn-helix domain	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HFD2_k127_8487466_5	1340493.JNIF01000003_gene3616	6.517e-29	127.0	COG0457@1|root,COG0457@2|Bacteria	1340493.JNIF01000003_gene3616|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8487466_1	234267.Acid_5562	1.073e-176	562.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_8487466_0	234267.Acid_5563	1.219e-185	596.0	COG5267@1|root,COG5267@2|Bacteria,3Y342@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_8487466_11	234267.Acid_1337	0.0003641	43.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyoxalase
HFD2_k127_8549032_1	1037409.BJ6T_42530	3.179e-58	214.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,3JVPI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HFD2_k127_8549032_0	234267.Acid_5585	2.609e-103	340.0	COG5523@1|root,COG5523@2|Bacteria	2|Bacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
HFD2_k127_8549032_4	861299.J421_5835	8.024e-19	93.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_8549032_2	639030.JHVA01000001_gene1884	7.349e-26	117.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8549032_5	565045.NOR51B_423	7.89e-08	55.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HFD2_k127_8572204_0	1267535.KB906767_gene98	1.009e-92	316.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria,2JI8Y@204432|Acidobacteriia	204432|Acidobacteriia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_8572204_2	1210884.HG799471_gene14673	4.994e-18	91.0	COG2010@1|root,COG3064@1|root,COG2010@2|Bacteria,COG3064@2|Bacteria,2IXU7@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
HFD2_k127_8572204_1	1123023.JIAI01000013_gene4027	9.329e-92	311.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HFD2_k127_8578266_0	1117958.PE143B_0100145	2.602e-193	616.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_24,rve
HFD2_k127_8578266_1	1267535.KB906767_gene3700	1.17e-107	361.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HFD2_k127_8578266_2	1382304.JNIL01000001_gene486	8.764e-71	250.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,278SD@186823|Alicyclobacillaceae	91061|Bacilli	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD2_k127_8580087_7	269482.Bcep1808_5563	2.812e-28	116.0	COG2336@1|root,COG2336@2|Bacteria,1NFRR@1224|Proteobacteria,2W4U5@28216|Betaproteobacteria,1K973@119060|Burkholderiaceae	28216|Betaproteobacteria	T	antitoxin	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HFD2_k127_8580087_4	1100720.ALKN01000007_gene2990	2.229e-43	160.0	COG2337@1|root,COG2337@2|Bacteria,1N0JV@1224|Proteobacteria,2VV5S@28216|Betaproteobacteria,4AIPN@80864|Comamonadaceae	28216|Betaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD2_k127_8580087_5	1209072.ALBT01000032_gene2124	1.078e-31	135.0	28MSC@1|root,2ZB0S@2|Bacteria,1R8PG@1224|Proteobacteria,1SNXF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8580087_6	234267.Acid_0917	1.369e-30	123.0	COG1278@1|root,COG1278@2|Bacteria,3Y5NU@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_8580087_3	204669.Acid345_1266	6.237e-45	172.0	COG2834@1|root,COG2834@2|Bacteria,3Y8R6@57723|Acidobacteria,2JNE5@204432|Acidobacteriia	204432|Acidobacteriia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8580087_0	234267.Acid_4986	1.512e-159	512.0	2CI5Q@1|root,2Z7M7@2|Bacteria,3Y3IR@57723|Acidobacteria	57723|Acidobacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HFD2_k127_8580087_2	639030.JHVA01000001_gene3336	1.805e-60	219.0	2CGTC@1|root,331SF@2|Bacteria,3Y7P6@57723|Acidobacteria,2JMRK@204432|Acidobacteriia	204432|Acidobacteriia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_8580087_1	702113.PP1Y_AT12349	2.209e-150	490.0	COG1858@1|root,COG1858@2|Bacteria,1REQ9@1224|Proteobacteria,2U8Q0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8580087_9	715226.ABI_44920	1.256e-08	67.0	2BU8Z@1|root,32PIG@2|Bacteria,1NUGX@1224|Proteobacteria,2US41@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_8580087_8	935840.JAEQ01000001_gene3195	8.018e-25	111.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43H8P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Pyrrolo-quinoline quinone	-	-	1.1.2.8,1.1.9.1	ko:K00114,ko:K17760	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HFD2_k127_8626576_4	234267.Acid_7470	8.369e-97	325.0	COG5360@1|root,COG5360@2|Bacteria,3Y4P7@57723|Acidobacteria	57723|Acidobacteria	S	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
HFD2_k127_8626576_1	1267535.KB906767_gene568	1.541e-138	454.0	COG2148@1|root,COG2148@2|Bacteria,3Y4JY@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HFD2_k127_8626576_7	330214.NIDE2858	3.832e-58	212.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD2_k127_8626576_0	234267.Acid_0553	5.654e-180	572.0	COG1004@1|root,COG1004@2|Bacteria,3Y3JZ@57723|Acidobacteria	57723|Acidobacteria	M	UDP binding domain	-	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_8626576_8	1267535.KB906767_gene2718	5.066e-35	142.0	COG0741@1|root,COG0741@2|Bacteria,3Y84I@57723|Acidobacteria,2JNI1@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD2_k127_8626576_3	234267.Acid_7464	1.417e-97	330.0	COG1377@1|root,COG1377@2|Bacteria,3Y4JK@57723|Acidobacteria	57723|Acidobacteria	NU	FlhB HrpN YscU SpaS Family	-	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
HFD2_k127_8626576_6	234267.Acid_7463	3.042e-64	229.0	COG1684@1|root,COG1684@2|Bacteria,3Y8C9@57723|Acidobacteria	57723|Acidobacteria	NU	Bacterial export proteins, family 1	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
HFD2_k127_8626576_10	1340493.JNIF01000003_gene3256	7.168e-12	70.0	COG1987@1|root,COG1987@2|Bacteria	2|Bacteria	N	bacterial-type flagellum assembly	fliQ	-	-	ko:K02420,ko:K03227	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	Bac_export_3
HFD2_k127_8626576_5	234267.Acid_7461	1.295e-95	319.0	COG1338@1|root,COG1338@2|Bacteria,3Y3K4@57723|Acidobacteria	57723|Acidobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
HFD2_k127_8626576_13	1030157.AFMP01000036_gene2623	1.003e-05	51.0	2EH03@1|root,33AS5@2|Bacteria,1R0X6@1224|Proteobacteria,2TYUY@28211|Alphaproteobacteria,2K72Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
HFD2_k127_8626576_11	234267.Acid_7459	9.923e-09	59.0	COG1886@1|root,COG1886@2|Bacteria,3Y94G@57723|Acidobacteria	57723|Acidobacteria	NU	Type III flagellar switch regulator (C-ring) FliN C-term	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
HFD2_k127_8626576_2	234267.Acid_7458	1.361e-121	402.0	COG1749@1|root,COG1749@2|Bacteria,3Y3C0@57723|Acidobacteria	57723|Acidobacteria	N	Flagellar basal body protein FlaE	-	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
HFD2_k127_8626576_9	1267535.KB906767_gene3915	7.939e-15	81.0	COG1843@1|root,COG1843@2|Bacteria	2|Bacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
HFD2_k127_8677211_4	765912.Thimo_1718	6.163e-15	78.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1WYTT@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD2_k127_8677211_5	1123024.AUII01000004_gene1506	1.249e-08	57.0	COG3093@1|root,COG3093@2|Bacteria,2IR2S@201174|Actinobacteria,4EC90@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	higA	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD2_k127_8677211_3	1267534.KB906754_gene3885	9.024e-19	91.0	2DR0H@1|root,339NS@2|Bacteria,3Y59F@57723|Acidobacteria,2JJP9@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD2_k127_8677211_1	1340493.JNIF01000004_gene143	8.018e-65	231.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_8677211_0	234267.Acid_0498	1.1e-272	847.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_8677211_2	234267.Acid_0497	4.307e-22	98.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD2_k127_8691020_3	979556.MTES_0700	2.029e-21	102.0	COG1609@1|root,COG1609@2|Bacteria,2GJHF@201174|Actinobacteria,4FMXS@85023|Microbacteriaceae	201174|Actinobacteria	K	Periplasmic binding protein-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
HFD2_k127_8691020_0	234267.Acid_2215	8.972e-183	578.0	COG0673@1|root,COG0673@2|Bacteria,3Y6W6@57723|Acidobacteria	57723|Acidobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_8691020_1	1267533.KB906743_gene813	4.343e-174	549.0	COG1082@1|root,COG1082@2|Bacteria,3Y3U5@57723|Acidobacteria,2JI4Y@204432|Acidobacteriia	204432|Acidobacteriia	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HFD2_k127_8691020_2	1267534.KB906758_gene2254	1.698e-103	338.0	COG0823@1|root,COG3828@1|root,COG0823@2|Bacteria,COG3828@2|Bacteria,3Y6DB@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_8693232_2	1379698.RBG1_1C00001G0655	8.731e-66	229.0	COG0380@1|root,COG0380@2|Bacteria,2NPDG@2323|unclassified Bacteria	2|Bacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135	ko:K00697,ko:K13057,ko:K20436	ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130	M00815	R02737,R08946,R10525,R11239,R11250,R11306,R11497	RC00005,RC00049,RC02748,RC03400,RC03401	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT20,GT4	-	Glyco_transf_20
HFD2_k127_8693232_3	42256.RradSPS_3037	6.513e-25	113.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HFD2_k127_8693232_4	335543.Sfum_2347	8.746e-19	96.0	COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,42RMM@68525|delta/epsilon subdivisions,2WNQY@28221|Deltaproteobacteria,2MQWR@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8693232_1	247490.KSU1_D0580	1.822e-146	479.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
HFD2_k127_8693232_6	926561.KB900620_gene3028	2.049e-11	74.0	2F3UD@1|root,33WKN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8693232_0	234267.Acid_2315	1.893e-275	872.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_8693232_5	1267535.KB906767_gene841	5.642e-14	75.0	COG0591@1|root,COG0591@2|Bacteria,3Y6FC@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_8717542_1	234267.Acid_4106	7.52e-161	514.0	COG1807@1|root,COG1807@2|Bacteria,3Y404@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_8717542_2	234267.Acid_4244	5.55e-104	350.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_8717542_4	234267.Acid_5140	6.265e-68	239.0	28IJE@1|root,2Z8KB@2|Bacteria,3Y46I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8717542_3	1267535.KB906767_gene4977	2.767e-101	337.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria,2JI8X@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HFD2_k127_8717542_0	234267.Acid_5844	3.484e-227	709.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HFD2_k127_8725858_1	1267535.KB906767_gene1134	1.312e-137	441.0	COG2873@1|root,COG2873@2|Bacteria,3Y2JU@57723|Acidobacteria,2JMB4@204432|Acidobacteriia	204432|Acidobacteriia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_8725858_0	639030.JHVA01000001_gene1777	3.345e-225	711.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria,2JIMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_8725858_4	234267.Acid_0917	2.301e-32	126.0	COG1278@1|root,COG1278@2|Bacteria,3Y5NU@57723|Acidobacteria	57723|Acidobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_8725858_2	760117.JN27_08570	2.955e-134	446.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,476TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_8725858_3	404589.Anae109_1343	6.381e-41	157.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_8745190_0	350058.Mvan_2212	1.038e-118	394.0	COG3344@1|root,COG3344@2|Bacteria,2GUJS@201174|Actinobacteria,233JN@1762|Mycobacteriaceae	201174|Actinobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
HFD2_k127_8745190_1	1108045.GORHZ_059_00010	7.853e-20	93.0	28NDD@1|root,2ZBG6@2|Bacteria,2H1UZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_884647_9	234267.Acid_2356	4.759e-80	272.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_884647_16	234267.Acid_2357	2.543e-26	109.0	COG2835@1|root,COG2835@2|Bacteria,3Y8VE@57723|Acidobacteria	57723|Acidobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HFD2_k127_884647_13	1340493.JNIF01000004_gene502	3.415e-51	194.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_884647_0	234267.Acid_1818	2.678e-249	785.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD2_k127_884647_7	1340493.JNIF01000003_gene3261	1.461e-90	306.0	COG1191@1|root,COG1191@2|Bacteria,3Y4Q5@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_884647_11	1340493.JNIF01000003_gene3264	2.385e-55	203.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria	57723|Acidobacteria	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HFD2_k127_884647_15	234267.Acid_5722	3.719e-47	184.0	COG3595@1|root,COG3595@2|Bacteria,3Y8P5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_884647_12	1267535.KB906767_gene4065	9.394e-54	202.0	COG1413@1|root,COG1413@2|Bacteria,3Y2TB@57723|Acidobacteria	57723|Acidobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
HFD2_k127_884647_8	234267.Acid_5720	4.019e-87	292.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_884647_1	234267.Acid_1915	1.129e-198	633.0	COG0539@1|root,COG0539@2|Bacteria,3Y3P3@57723|Acidobacteria	57723|Acidobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_884647_5	234267.Acid_7135	7.566e-140	456.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria	57723|Acidobacteria	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HFD2_k127_884647_4	1267535.KB906767_gene4644	1.083e-163	525.0	COG0743@1|root,COG0743@2|Bacteria,3Y30J@57723|Acidobacteria,2JI5H@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD2_k127_884647_6	1340493.JNIF01000003_gene3625	3.306e-108	358.0	COG2084@1|root,COG2084@2|Bacteria,3Y45W@57723|Acidobacteria	57723|Acidobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_884647_2	1267535.KB906767_gene4646	5.812e-177	562.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338,M00609	R00782,R00999,R01001,R01283,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00487,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02814,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HFD2_k127_884647_14	1267535.KB906767_gene4845	1.505e-49	186.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria,2JJBS@204432|Acidobacteriia	204432|Acidobacteriia	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_884647_3	234267.Acid_1013	4.421e-174	551.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria	57723|Acidobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD2_k127_884647_10	1340493.JNIF01000003_gene2519	4.6e-71	256.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_885906_8	234267.Acid_3582	1.774e-52	191.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_885906_4	234267.Acid_3576	4.317e-117	384.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD2_k127_885906_2	1267535.KB906767_gene5096	5.35e-150	478.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria,2JI2H@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_885906_3	1340493.JNIF01000004_gene384	7.384e-132	439.0	COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD2_k127_885906_5	234267.Acid_1510	1.395e-113	388.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_885906_1	234267.Acid_1509	4.899e-209	664.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_885906_10	1267535.KB906767_gene4761	2.829e-33	135.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HFD2_k127_885906_7	234267.Acid_4300	2.759e-60	213.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HFD2_k127_885906_9	1340493.JNIF01000003_gene4501	1.044e-45	166.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U2@57723|Acidobacteria	57723|Acidobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_885906_0	234267.Acid_4298	9.302e-268	835.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3Y3DA@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_885906_11	234267.Acid_3321	1.964e-21	99.0	2CB8T@1|root,349A2@2|Bacteria,3Y8JH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
HFD2_k127_885906_6	330084.JNYZ01000001_gene3228	1.832e-65	235.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4E95H@85010|Pseudonocardiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3,NAD_binding_8
HFD2_k127_915329_1	234267.Acid_4761	6.985e-132	425.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_915329_4	234267.Acid_0799	1.908e-68	237.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria	57723|Acidobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD2_k127_915329_0	1340493.JNIF01000004_gene816	5.47e-251	780.0	COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD2_k127_915329_2	1340493.JNIF01000004_gene817	5.099e-91	305.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria	57723|Acidobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_915329_3	1267535.KB906767_gene5476	3.083e-74	263.0	COG0859@1|root,COG0859@2|Bacteria,3Y794@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HFD2_k127_915329_5	234267.Acid_7058	4.18e-67	230.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_930036_0	234267.Acid_0554	6.315e-215	711.0	COG1404@1|root,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria	57723|Acidobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_930036_1	234267.Acid_0749	1.678e-77	264.0	COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria	57723|Acidobacteria	H	MoeZ MoeB domain	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD2_k127_937761_13	234267.Acid_0461	5.543e-06	51.0	COG0711@1|root,COG0711@2|Bacteria,3Y4UJ@57723|Acidobacteria	57723|Acidobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_937761_10	234267.Acid_0460	9.764e-28	117.0	COG0711@1|root,COG0711@2|Bacteria,3Y4WK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the ATPase B chain family	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_937761_8	240015.ACP_0640	1.687e-46	173.0	COG2898@1|root,COG2898@2|Bacteria,3Y4M0@57723|Acidobacteria,2JJ8Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_937761_5	234267.Acid_3892	5.285e-71	254.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	2|Bacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_937761_3	760192.Halhy_5620	2.446e-115	385.0	COG0477@1|root,COG2814@2|Bacteria,4PNZI@976|Bacteroidetes	976|Bacteroidetes	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_937761_4	1340493.JNIF01000004_gene325	1.159e-75	265.0	COG4912@1|root,COG4912@2|Bacteria,3Y5U2@57723|Acidobacteria	57723|Acidobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
HFD2_k127_937761_12	933262.AXAM01000172_gene935	3.618e-08	58.0	COG0864@1|root,COG0864@2|Bacteria,1N84E@1224|Proteobacteria,42VWB@68525|delta/epsilon subdivisions,2WRHU@28221|Deltaproteobacteria,2MNZW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HFD2_k127_937761_11	589865.DaAHT2_0745	6.683e-21	96.0	COG2337@1|root,COG2337@2|Bacteria,1N1DE@1224|Proteobacteria,42WAI@68525|delta/epsilon subdivisions,2WRAJ@28221|Deltaproteobacteria,2MNJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD2_k127_937761_2	379066.GAU_2382	1.885e-142	461.0	COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_937761_1	379066.GAU_2381	4.366e-254	798.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1ZSVF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HFD2_k127_937761_0	861299.J421_1491	7.252e-283	879.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
HFD2_k127_937761_6	1232683.ADIMK_0864	4.368e-66	234.0	COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,1S4PV@1236|Gammaproteobacteria,468BT@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_937761_7	1267535.KB906767_gene3898	2.254e-59	220.0	COG0671@1|root,COG0671@2|Bacteria,3Y72A@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD2_k127_937761_9	1382359.JIAL01000001_gene94	6.253e-33	129.0	COG3288@1|root,COG3288@2|Bacteria,3Y2S0@57723|Acidobacteria,2JM52@204432|Acidobacteriia	204432|Acidobacteriia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD2_k127_952387_5	204669.Acid345_1013	4.402e-09	59.0	2EFZF@1|root,339RM@2|Bacteria,3Y5X5@57723|Acidobacteria,2JK63@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_952387_0	316067.Geob_3238	8.946e-286	896.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,42NSN@68525|delta/epsilon subdivisions,2WJF7@28221|Deltaproteobacteria,43TN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD2_k127_952387_1	644968.DFW101_2128	7.107e-271	848.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2MEEN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HFD2_k127_952387_3	69395.JQLZ01000001_gene2976	8.376e-18	83.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,2KHAQ@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD2_k127_952387_2	204669.Acid345_3454	1.087e-74	258.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_952387_4	1090318.ATTI01000001_gene697	5.788e-13	69.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_964619_5	1267535.KB906767_gene4444	2.551e-63	225.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria,2JJ89@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_964619_7	204669.Acid345_3851	1.969e-10	69.0	COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria,2JJ7U@204432|Acidobacteriia	204432|Acidobacteriia	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_964619_4	234267.Acid_5541	3.753e-69	243.0	COG0030@1|root,COG0030@2|Bacteria,3Y3RQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD2_k127_964619_3	1267535.KB906767_gene2709	7.271e-72	243.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria,2JJ7D@204432|Acidobacteriia	204432|Acidobacteriia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD2_k127_964619_2	1267535.KB906767_gene2708	1.575e-81	273.0	COG0049@1|root,COG0049@2|Bacteria,3Y3FF@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD2_k127_964619_0	1267535.KB906767_gene2707	0.0	1166.0	COG0480@1|root,COG0480@2|Bacteria,3Y2YX@57723|Acidobacteria,2JIQP@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_964619_1	234267.Acid_5120	9.489e-120	386.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_968292_7	234267.Acid_0367	1.536e-24	109.0	COG0500@1|root,COG0500@2|Bacteria,3Y7QV@57723|Acidobacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,NodS,ParBc,Polysacc_deac_1
HFD2_k127_968292_2	1267535.KB906767_gene4988	6.795e-113	372.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HFD2_k127_968292_3	1267535.KB906767_gene1314	3.618e-105	346.0	COG3605@1|root,COG3707@1|root,COG3605@2|Bacteria,COG3707@2|Bacteria,3Y72Q@57723|Acidobacteria,2JP7X@204432|Acidobacteriia	2|Bacteria	T	GAF domain	nasR	-	4.6.1.1	ko:K01768,ko:K02584,ko:K07183,ko:K22010	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00695,M00839	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022,ko03000	-	-	-	ANTAR,GAF_2,Response_reg
HFD2_k127_968292_1	234267.Acid_3771	1.268e-125	416.0	COG2010@1|root,COG2010@2|Bacteria,3Y44D@57723|Acidobacteria	57723|Acidobacteria	C	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_968292_0	234267.Acid_4421	5.866e-176	562.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HFD2_k127_968292_6	1267535.KB906767_gene671	1.6e-45	168.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_968292_4	1340493.JNIF01000003_gene4083	4.912e-97	322.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria	57723|Acidobacteria	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD2_k127_968292_5	234267.Acid_5910	4.865e-60	216.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD2_k127_97443_12	234267.Acid_5011	2.198e-12	74.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD2_k127_97443_0	1265505.ATUG01000002_gene1318	2.006e-171	549.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,42U9J@68525|delta/epsilon subdivisions,2WQ39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	ko:K05548,ko:K05819,ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4
HFD2_k127_97443_6	1004785.AMBLS11_05135	2.379e-64	226.0	COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,1SYDI@1236|Gammaproteobacteria,464WD@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	iJN746.PP_0100	Pro_CA
HFD2_k127_97443_2	1247963.JPHU01000001_gene2058	2.367e-95	329.0	COG0477@1|root,COG0477@2|Bacteria,1QU36@1224|Proteobacteria,2TVXA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K07552,ko:K18552	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.3	-	-	MFS_1
HFD2_k127_97443_11	247633.GP2143_17801	1.494e-14	75.0	2C42J@1|root,336T0@2|Bacteria,1NFNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_97443_3	1340493.JNIF01000003_gene2821	1.628e-89	301.0	COG0290@1|root,COG0290@2|Bacteria,3Y3VP@57723|Acidobacteria	57723|Acidobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HFD2_k127_97443_9	234267.Acid_7216	3.422e-23	102.0	COG3115@1|root,COG3115@2|Bacteria	2|Bacteria	D	cell septum assembly	-	-	-	ko:K02487,ko:K06596,ko:K08372	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko02022,ko02035	-	-	-	FliO,SPOR,ZipA_C
HFD2_k127_97443_10	1236959.BAMT01000015_gene2849	2.983e-22	102.0	2BUQD@1|root,32Q1F@2|Bacteria,1PJPP@1224|Proteobacteria,2W83R@28216|Betaproteobacteria,2KNSW@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_97443_7	1340493.JNIF01000003_gene2123	1.484e-41	164.0	28MSC@1|root,2ZB0S@2|Bacteria,3Y8PH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_97443_1	682795.AciX8_3558	2.865e-140	464.0	COG1506@1|root,COG1506@2|Bacteria,3Y6MJ@57723|Acidobacteria,2JMBK@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_97443_8	97096.XP_007790920.1	3.119e-41	155.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_97443_5	97096.XP_007790920.1	5.216e-65	231.0	COG1574@1|root,2RS8Z@2759|Eukaryota,3918Y@33154|Opisthokonta,3PXJ9@4751|Fungi,3RGKA@4890|Ascomycota,21EIX@147550|Sordariomycetes	4751|Fungi	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
## 3615 queries scanned
## Total time (seconds): 158.51451635360718
## Rate: 22.81 q/s