## Tue Nov 12 16:00:16 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD2_bin.3.fa -m mmseqs --itype genome -o HFD2_bin.3 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD2_bin.3 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD2_k127_1006191_1	204669.Acid345_0972	1.202e-74	257.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria,2JIR0@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1006191_0	204669.Acid345_0973	9.01e-130	435.0	COG4585@1|root,COG4585@2|Bacteria,3Y8CF@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_1006191_3	396588.Tgr7_2147	3.169e-05	54.0	2BUQU@1|root,32Q1X@2|Bacteria,1PJQ9@1224|Proteobacteria,1SJ7J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HFD2_k127_1006191_4	215803.DB30_3768	0.0001282	51.0	COG5662@1|root,COG5662@2|Bacteria,1QAKH@1224|Proteobacteria,434DQ@68525|delta/epsilon subdivisions,2WYQS@28221|Deltaproteobacteria,2Z0DX@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_1006191_2	234267.Acid_0312	5.839e-57	204.0	COG1595@1|root,COG1595@2|Bacteria,3Y2V2@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1006868_2	234267.Acid_6893	1.538e-47	174.0	COG1388@1|root,COG1388@2|Bacteria,3Y4VG@57723|Acidobacteria	57723|Acidobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD2_k127_1006868_3	240015.ACP_2133	3.688e-24	109.0	COG4770@1|root,COG4770@2|Bacteria,3Y5TC@57723|Acidobacteria,2JNZR@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HFD2_k127_1006868_1	204669.Acid345_0157	2.007e-82	286.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria,2JHQ4@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
HFD2_k127_1006868_4	1121920.AUAU01000005_gene944	1.406e-20	93.0	COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD2_k127_1006868_0	13690.CP98_02413	2.666e-85	299.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,2TQUT@28211|Alphaproteobacteria,2K25H@204457|Sphingomonadales	204457|Sphingomonadales	E	Selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_1006868_5	682795.AciX8_0365	0.0006574	46.0	2A6XZ@1|root,30VSX@2|Bacteria,3Y4RH@57723|Acidobacteria,2JJCB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1016405_7	1050202.KB913024_gene3612	0.0002938	48.0	2CIGV@1|root,32S80@2|Bacteria,2IT9G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1016405_5	682795.AciX8_3113	4.962e-78	269.0	COG4099@1|root,COG4099@2|Bacteria,3Y5YX@57723|Acidobacteria,2JMZ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD2_k127_1016405_4	398720.MED217_08240	2.427e-115	384.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia	976|Bacteroidetes	Q	Imidazolonepropionase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_1016405_0	1267535.KB906767_gene2552	0.0	1313.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y3BP@57723|Acidobacteria,2JMMF@204432|Acidobacteriia	204432|Acidobacteriia	M	Tricorn protease PDZ domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HFD2_k127_1016405_3	1348583.ATLH01000022_gene2273	8.492e-116	389.0	COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1HYRS@117743|Flavobacteriia,1FA0I@104264|Cellulophaga	976|Bacteroidetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_1016405_2	234267.Acid_2148	1.139e-173	556.0	COG0612@1|root,COG0612@2|Bacteria,3Y77X@57723|Acidobacteria	57723|Acidobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_1016405_6	1123242.JH636436_gene522	7.891e-73	254.0	COG1878@1|root,COG1878@2|Bacteria,2IZXG@203682|Planctomycetes	203682|Planctomycetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_1016405_1	215803.DB30_4063	1.424e-251	786.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HFD2_k127_1030872_1	448385.sce5876	3.389e-107	354.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	allB	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_1030872_0	1254432.SCE1572_35005	3.341e-183	586.0	COG3195@1|root,COG4266@1|root,COG3195@2|Bacteria,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,42YE0@68525|delta/epsilon subdivisions,2X30N@28221|Deltaproteobacteria,2YTWS@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase,OHCU_decarbox
HFD2_k127_1030872_2	28042.GU90_05015	1.064e-36	147.0	COG2351@1|root,COG2351@2|Bacteria,2IQUN@201174|Actinobacteria,4E5V4@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
HFD2_k127_1030872_3	1122612.AUBA01000002_gene1883	1.644e-08	55.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2TSXN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD2_k127_103860_1	278963.ATWD01000001_gene1201	4.816e-60	219.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria,2JIUC@204432|Acidobacteriia	204432|Acidobacteriia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	IMS
HFD2_k127_103860_0	234267.Acid_7035	1.711e-191	611.0	COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD2_k127_104313_1	682795.AciX8_3014	5.966e-45	168.0	COG0020@1|root,COG0020@2|Bacteria,3Y4GH@57723|Acidobacteria,2JKFI@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD2_k127_104313_3	204669.Acid345_1350	9.238e-35	139.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria,2JJTC@204432|Acidobacteriia	204432|Acidobacteriia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_104313_6	1382359.JIAL01000001_gene590	1.996e-07	56.0	arCOG13401@1|root,33MMV@2|Bacteria,3Y5TE@57723|Acidobacteria,2JNR5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
HFD2_k127_104313_5	234267.Acid_5392	4.177e-20	94.0	2CTSB@1|root,32SU2@2|Bacteria,3Y567@57723|Acidobacteria	57723|Acidobacteria	S	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_104313_2	996637.SGM_2790	2.756e-39	158.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
HFD2_k127_104313_0	234267.Acid_2726	2.947e-45	179.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_104313_7	1267535.KB906767_gene3728	1.072e-05	49.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_1044420_5	926550.CLDAP_23540	4.212e-93	321.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
HFD2_k127_1044420_2	1071679.BG57_29860	1.593e-111	369.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Methyltransferase	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HFD2_k127_1044420_0	1071679.BG57_05335	2.82e-160	516.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VNKT@28216|Betaproteobacteria,1KGZG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_1044420_4	1173026.Glo7428_2778	1.767e-97	325.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria	1117|Cyanobacteria	E	'ABC-type proline glycine betaine transport	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
HFD2_k127_1044420_6	1267533.KB906737_gene1546	8.055e-71	245.0	COG1174@1|root,COG1174@2|Bacteria,3Y3BN@57723|Acidobacteria,2JI8U@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HFD2_k127_1044420_3	1382359.JIAL01000001_gene203	7.933e-106	360.0	COG1732@1|root,COG1732@2|Bacteria,3Y3Z9@57723|Acidobacteria,2JIDY@204432|Acidobacteriia	204432|Acidobacteriia	M	ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HFD2_k127_1044420_1	1174528.JH992893_gene5975	3.223e-145	471.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae	1117|Cyanobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_1081500_4	1096930.L284_12450	0.0002559	46.0	COG2936@1|root,COG2936@2|Bacteria,1R2BJ@1224|Proteobacteria,2TZGD@28211|Alphaproteobacteria,2K5IN@204457|Sphingomonadales	204457|Sphingomonadales	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15
HFD2_k127_1081500_1	204669.Acid345_3536	6.65e-84	294.0	COG1253@1|root,COG1253@2|Bacteria,3Y3MC@57723|Acidobacteria,2JIF9@204432|Acidobacteriia	204432|Acidobacteriia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HFD2_k127_1081500_3	926566.Terro_1027	1.239e-23	106.0	COG0319@1|root,COG0319@2|Bacteria,3Y53R@57723|Acidobacteria,2JJPS@204432|Acidobacteriia	204432|Acidobacteriia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HFD2_k127_1081500_0	234267.Acid_7711	4.341e-130	423.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria	57723|Acidobacteria	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HFD2_k127_1081500_2	666685.R2APBS1_3416	8.67e-53	194.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S5WE@1236|Gammaproteobacteria,1X3ZI@135614|Xanthomonadales	135614|Xanthomonadales	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_1082447_0	204669.Acid345_1211	6.557e-88	301.0	COG0621@1|root,COG0621@2|Bacteria,3Y41R@57723|Acidobacteria,2JKPA@204432|Acidobacteriia	204432|Acidobacteriia	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HFD2_k127_1082447_2	234267.Acid_6712	9.305e-40	154.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria	57723|Acidobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD2_k127_1082447_1	861299.J421_5994	1.963e-40	160.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD2_k127_1083514_4	1232410.KI421413_gene713	1.364e-35	146.0	2DE9Y@1|root,2ZM4N@2|Bacteria,1Q17X@1224|Proteobacteria,43756@68525|delta/epsilon subdivisions,2X21C@28221|Deltaproteobacteria,43SFZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1083514_5	1033743.CAES01000033_gene1117	5.149e-29	130.0	COG2971@1|root,COG2971@2|Bacteria,1V0VG@1239|Firmicutes,4HHQE@91061|Bacilli,275Q0@186822|Paenibacillaceae	91061|Bacilli	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD2_k127_1083514_0	234267.Acid_4784	1.168e-161	524.0	COG0591@1|root,COG0591@2|Bacteria,3Y419@57723|Acidobacteria	57723|Acidobacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_1083514_1	234267.Acid_4783	6.938e-120	404.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_1083514_2	1536769.P40081_16990	1.284e-59	220.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,26QWM@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1083514_8	234267.Acid_4755	1.941e-05	55.0	COG0577@1|root,COG0577@2|Bacteria,3Y78V@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1083514_6	1267535.KB906767_gene1916	9.121e-26	110.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD2_k127_1083514_3	1134912.AJTV01000002_gene1748	7.115e-46	175.0	2AC8B@1|root,311T0@2|Bacteria,1NK0P@1224|Proteobacteria,2VD5M@28211|Alphaproteobacteria,3713U@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1121300_1	234267.Acid_3794	1.009e-46	188.0	COG3266@1|root,COG3266@2|Bacteria,3Y4N4@57723|Acidobacteria	57723|Acidobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_1121300_2	1128421.JAGA01000002_gene1047	4.978e-33	135.0	COG0817@1|root,COG0817@2|Bacteria,2NPKS@2323|unclassified Bacteria	2|Bacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD2_k127_1121300_0	204669.Acid345_2125	2.06e-96	321.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria,2JIJW@204432|Acidobacteriia	204432|Acidobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD2_k127_1165296_0	204669.Acid345_1186	2.066e-100	329.0	COG0717@1|root,COG0717@2|Bacteria,3Y42N@57723|Acidobacteria,2JIA0@204432|Acidobacteriia	204432|Acidobacteriia	F	dUTPase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HFD2_k127_1165296_6	1122222.AXWR01000014_gene1274	1.563e-60	218.0	COG0041@1|root,COG0041@2|Bacteria,1WJ89@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HFD2_k127_1165296_9	331869.BAL199_21474	3.541e-35	137.0	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2UBXR@28211|Alphaproteobacteria,4BQPN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Small Multidrug Resistance protein	qacE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HFD2_k127_1165296_8	1267534.KB906761_gene1208	1.568e-40	152.0	COG0640@1|root,COG0640@2|Bacteria,3Y5C4@57723|Acidobacteria,2JNKM@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_1165296_7	69395.JQLZ01000005_gene3678	8.182e-53	191.0	COG3832@1|root,COG3832@2|Bacteria,1RJJY@1224|Proteobacteria,2U9FZ@28211|Alphaproteobacteria,2KIZS@204458|Caulobacterales	204458|Caulobacterales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_1165296_4	926560.KE387023_gene3304	1.421e-63	221.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
HFD2_k127_1165296_2	1157490.EL26_21235	2.023e-71	248.0	COG1741@1|root,COG1741@2|Bacteria,1TSV4@1239|Firmicutes,4II2H@91061|Bacilli,279EZ@186823|Alicyclobacillaceae	91061|Bacilli	S	Pirin	-	-	-	-	-	-	-	-	-	-	-	-	Pirin
HFD2_k127_1165296_1	211165.AJLN01000068_gene4640	2.318e-76	262.0	COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,1JITT@1189|Stigonemataceae	1117|Cyanobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_1165296_5	378806.STAUR_6545	1.047e-62	222.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42T4I@68525|delta/epsilon subdivisions,2WPAC@28221|Deltaproteobacteria,2YW13@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_1165296_3	204669.Acid345_2262	1.538e-65	231.0	COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria,2JJ3I@204432|Acidobacteriia	204432|Acidobacteriia	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_1165296_10	1382359.JIAL01000001_gene2512	1.311e-16	93.0	COG2304@1|root,COG2304@2|Bacteria,3Y98T@57723|Acidobacteria,2JP5A@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1169407_3	204669.Acid345_4390	5.684e-57	204.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_1169407_2	234267.Acid_7162	1.413e-145	474.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_1169407_1	861299.J421_1476	5.579e-156	501.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD2_k127_1169407_0	1382359.JIAL01000001_gene1410	5.021e-298	930.0	COG3250@1|root,COG3250@2|Bacteria,3Y6CM@57723|Acidobacteria,2JKZF@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, family 2, TIM barrel	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD2_k127_1169612_0	204669.Acid345_3920	1.506e-138	449.0	COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_1169612_1	1122137.AQXF01000003_gene2417	3.829e-68	243.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_1176629_0	204669.Acid345_3370	8.094e-183	601.0	COG2366@1|root,COG2366@2|Bacteria,3Y2PX@57723|Acidobacteria,2JHKH@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD2_k127_1176629_2	765869.BDW_00710	1.66e-13	79.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD2_k127_1176629_1	234267.Acid_1114	8.029e-96	321.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_1176629_3	1507.HMPREF0262_00743	3.43e-07	53.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,36EDU@31979|Clostridiaceae	186801|Clostridia	J	Methyltransferase	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD2_k127_1182593_0	1382359.JIAL01000001_gene2716	8.554e-233	728.0	COG0538@1|root,COG0538@2|Bacteria,3Y2WW@57723|Acidobacteria,2JHTU@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_1182593_1	204669.Acid345_1951	2.186e-131	430.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria,2JII1@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HFD2_k127_1182593_2	1429916.X566_21020	1.998e-59	214.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_1182593_3	518766.Rmar_0331	1.064e-25	112.0	COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1FJUG@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD2_k127_1182593_4	234267.Acid_4370	1.937e-12	69.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria	57723|Acidobacteria	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HFD2_k127_1188775_0	269799.Gmet_1652	0.0	1327.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43T46@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K18138	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_1188775_1	379066.GAU_0097	1.089e-223	715.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
HFD2_k127_1188775_2	266117.Rxyl_1153	1.235e-60	218.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4CQ1B@84995|Rubrobacteria	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_1193436_2	1382359.JIAL01000001_gene956	9.347e-44	161.0	COG2109@1|root,COG2109@2|Bacteria,3Y4DE@57723|Acidobacteria,2JJ2Y@204432|Acidobacteriia	204432|Acidobacteriia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
HFD2_k127_1193436_0	1267535.KB906767_gene1747	2.417e-115	378.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria,2JI81@204432|Acidobacteriia	204432|Acidobacteriia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_1193436_1	204669.Acid345_0119	1.306e-60	220.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria,2JI7I@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Mur ligase	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_1206251_0	1191523.MROS_1385	5.154e-191	616.0	COG1067@1|root,COG1067@2|Bacteria	2|Bacteria	O	ATP-dependent peptidase activity	ycbZ	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C
HFD2_k127_1206251_3	204669.Acid345_3561	2.56e-43	171.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD2_k127_1206251_2	234267.Acid_2835	1.032e-43	170.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1206251_1	1382359.JIAL01000001_gene517	1.304e-52	189.0	COG0780@1|root,COG0780@2|Bacteria,3Y4ND@57723|Acidobacteria,2JJ9J@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD2_k127_123739_3	240015.ACP_1042	1.052e-83	292.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	hpnI	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HFD2_k127_123739_9	883078.HMPREF9695_03477	3.887e-28	116.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2UC1Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HFD2_k127_123739_13	1267535.KB906767_gene1333	2.294e-06	56.0	COG0745@1|root,COG0745@2|Bacteria,3Y8Y3@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_123739_14	1265756.AWZW01000008_gene1184	9.374e-05	51.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,4BP6F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_123739_6	296591.Bpro_0708	1.303e-67	251.0	COG3447@1|root,COG4585@1|root,COG3447@2|Bacteria,COG4585@2|Bacteria,1PF0H@1224|Proteobacteria,2W8ZC@28216|Betaproteobacteria,4AI7H@80864|Comamonadaceae	28216|Betaproteobacteria	T	MASE1	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,MASE1
HFD2_k127_123739_5	1054213.HMPREF9946_03239	4.397e-70	245.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,2JYMX@204441|Rhodospirillales	204441|Rhodospirillales	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_123739_1	591001.Acfer_0154	2.399e-111	372.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,4H2WR@909932|Negativicutes	909932|Negativicutes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_123739_4	1379698.RBG1_1C00001G1555	9.644e-79	269.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5,NinG
HFD2_k127_123739_12	928724.SacglDRAFT_03242	5.064e-08	62.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4E3HX@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HFD2_k127_123739_2	485913.Krac_1174	1.832e-102	343.0	COG0861@1|root,COG0861@2|Bacteria,2G66P@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HFD2_k127_123739_8	234267.Acid_0699	1.718e-35	147.0	COG0810@1|root,COG0810@2|Bacteria,3Y5QN@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_123739_7	204669.Acid345_1862	8.751e-63	231.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_123739_0	694431.DESACE_02320	1.628e-177	572.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M6R5@213113|Desulfurellales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD2_k127_1254787_0	240015.ACP_2227	1.264e-104	361.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria,2JI8D@204432|Acidobacteriia	204432|Acidobacteriia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HFD2_k127_1254787_1	204669.Acid345_4120	3.335e-70	257.0	COG0147@1|root,COG0147@2|Bacteria,3Y2UX@57723|Acidobacteria,2JIMP@204432|Acidobacteriia	204432|Acidobacteriia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HFD2_k127_1267702_0	886293.Sinac_1691	3.631e-212	676.0	COG3379@1|root,COG3379@2|Bacteria,2IXA8@203682|Planctomycetes	203682|Planctomycetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_1267784_2	401053.AciPR4_1419	6.102e-22	95.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_1267784_0	1229909.NSED_09965	1.492e-102	359.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD2_k127_1267784_1	768670.Calni_0876	4.319e-53	189.0	COG0192@1|root,COG0192@2|Bacteria,2GF8F@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_1269161_4	880073.Calab_2509	1.22e-22	100.0	COG0603@1|root,COG0603@2|Bacteria,2NPD6@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
HFD2_k127_1269161_3	1150864.MILUP08_43252	5.84e-23	102.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria,4DDM4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
HFD2_k127_1269161_5	1150864.MILUP08_43250	1.293e-13	76.0	2DRM1@1|root,33C8J@2|Bacteria,2IJ2W@201174|Actinobacteria,4DEIM@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1269161_1	204669.Acid345_4643	2.932e-71	250.0	COG0602@1|root,COG0602@2|Bacteria,3Y2UA@57723|Acidobacteria,2JICV@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_1269161_2	204669.Acid345_4642	6.22e-47	172.0	COG0720@1|root,COG0720@2|Bacteria,3Y4HE@57723|Acidobacteria,2JJ9Q@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD2_k127_1269161_0	204669.Acid345_4634	5.166e-107	353.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HFD2_k127_1280749_6	204669.Acid345_0424	1.528e-63	230.0	COG0457@1|root,COG0457@2|Bacteria,3Y7EI@57723|Acidobacteria,2JKWT@204432|Acidobacteriia	204432|Acidobacteriia	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_1280749_3	204669.Acid345_0321	4.936e-162	517.0	COG2017@1|root,COG2017@2|Bacteria,3Y3D2@57723|Acidobacteria,2JIDQ@204432|Acidobacteriia	204432|Acidobacteriia	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD2_k127_1280749_2	682795.AciX8_4751	1.22e-190	616.0	COG4805@1|root,COG4805@2|Bacteria,3Y70G@57723|Acidobacteria,2JKI1@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD2_k127_1280749_0	234267.Acid_7605	2.943e-285	894.0	COG1501@1|root,COG1501@2|Bacteria,3Y4C8@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Glyco_hydro_31
HFD2_k127_1280749_7	926554.KI912671_gene374	5.129e-40	162.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_1280749_1	682795.AciX8_4774	8.968e-199	633.0	COG1501@1|root,COG1501@2|Bacteria,3Y35Y@57723|Acidobacteria,2JI95@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, clan GH-D	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2
HFD2_k127_1280749_5	1379270.AUXF01000007_gene963	3.298e-133	441.0	COG0006@1|root,COG0006@2|Bacteria,1ZUQY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminopeptidase P, N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD2_k127_1280749_4	682795.AciX8_4776	9.568e-153	497.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_4,CBM_35,DUF1080,Dockerin_1,F5_F8_type_C,Flg_new,GH97_C,GH97_N,Glyco_hydro_127,Glyco_hydro_43,Glyco_hydro_97,LRR_5,Laminin_G_3
HFD2_k127_1294191_0	204669.Acid345_4229	2.773e-73	260.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3Y2NW@57723|Acidobacteria,2JHNM@204432|Acidobacteriia	204432|Acidobacteriia	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD2_k127_1294191_1	204669.Acid345_4230	1.378e-12	72.0	COG2815@1|root,COG2815@2|Bacteria,3Y4UG@57723|Acidobacteria,2JJF0@204432|Acidobacteriia	204432|Acidobacteriia	S	PASTA domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
HFD2_k127_1304362_1	1125863.JAFN01000001_gene1971	9.819e-54	195.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria	1224|Proteobacteria	EM	Belongs to the DapA family	yagE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28,4.3.3.7	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01782,R10147	RC00307,RC00572,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_1304362_0	1121035.AUCH01000002_gene1691	1.778e-284	894.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales	206389|Rhodocyclales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD2_k127_1316437_0	204669.Acid345_1535	3.973e-246	767.0	COG1012@1|root,COG1012@2|Bacteria,3Y384@57723|Acidobacteria,2JIA8@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85	ko:K00128,ko:K00130,ko:K00146,ko:K10217	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00555,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_1316437_7	1500894.JQNN01000001_gene1572	9.828e-74	255.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,473D5@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Coenzyme A transferase	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_1316437_8	1218084.BBJK01000175_gene7916	3.653e-69	242.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VIR2@28216|Betaproteobacteria,1K1JX@119060|Burkholderiaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	pcaI	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_1316437_13	485913.Krac_1722	6.748e-21	101.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi	200795|Chloroflexi	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HFD2_k127_1316437_3	266117.Rxyl_0958	2.027e-98	331.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CPHB@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HFD2_k127_1316437_6	266117.Rxyl_0961	1.107e-75	262.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HFD2_k127_1316437_10	1220534.B655_0507	1.014e-45	173.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,23PI0@183925|Methanobacteria	183925|Methanobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD2_k127_1316437_12	1379698.RBG1_1C00001G0849	6.193e-21	99.0	COG1959@1|root,COG1959@2|Bacteria,2NQ8B@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, BadM Rrf2 family	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_1316437_11	1379698.RBG1_1C00001G0849	2.978e-34	136.0	COG1959@1|root,COG1959@2|Bacteria,2NQ8B@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, BadM Rrf2 family	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_1316437_2	1379698.RBG1_1C00001G0892	7.119e-118	388.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
HFD2_k127_1316437_1	1379698.RBG1_1C00001G0907	1.874e-132	430.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_1316437_9	1379698.RBG1_1C00001G0906	1.098e-66	234.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_1316437_5	1187851.A33M_3196	2.939e-92	317.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2U2IH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HFD2_k127_1316437_4	316057.RPD_1537	4.26e-97	329.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HFD2_k127_1318106_0	562970.Btus_3110	2.831e-108	355.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HB3V@91061|Bacilli,279I2@186823|Alicyclobacillaceae	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_1318106_2	1267535.KB906767_gene5200	3.606e-22	102.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rpbA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_1318106_1	330214.NIDE1125	2.08e-86	301.0	COG0301@1|root,COG0301@2|Bacteria	2|Bacteria	H	tRNA thio-modification	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
HFD2_k127_1319221_0	234267.Acid_4221	1.303e-107	356.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HFD2_k127_1319221_1	240015.ACP_3414	2.321e-49	179.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3Y2WU@57723|Acidobacteria,2JHYV@204432|Acidobacteriia	204432|Acidobacteriia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD2_k127_1320268_2	926550.CLDAP_34250	2.572e-17	85.0	COG0696@1|root,COG0696@2|Bacteria,2G7GD@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
HFD2_k127_1320268_3	649638.Trad_1454	2.746e-06	49.0	COG0696@1|root,COG0696@2|Bacteria,1WIS3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Metalloenzyme	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
HFD2_k127_1320268_1	85643.Tmz1t_0547	1.542e-36	148.0	COG0457@1|root,COG0457@2|Bacteria,1R48M@1224|Proteobacteria,2VJUM@28216|Betaproteobacteria,2KYT3@206389|Rhodocyclales	206389|Rhodocyclales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1320268_0	931627.MycrhDRAFT_1785	5.133e-126	417.0	COG3621@1|root,COG3621@2|Bacteria,2I97F@201174|Actinobacteria,23F3R@1762|Mycobacteriaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_1330959_3	204669.Acid345_2892	4.604e-07	56.0	COG4932@1|root,COG4932@2|Bacteria,3Y5W1@57723|Acidobacteria,2JNVI@204432|Acidobacteriia	204432|Acidobacteriia	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_1330959_0	273068.TTE0025	9.697e-163	524.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,42EYY@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD2_k127_1330959_2	1385520.N802_03530	3.196e-07	57.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FEV4@85021|Intrasporangiaceae	201174|Actinobacteria	P	COG2217 Cation transport ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
HFD2_k127_1330959_1	1382306.JNIM01000001_gene1328	7.599e-146	471.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_133724_1	861299.J421_5946	4.289e-282	899.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HFD2_k127_133724_0	234267.Acid_5051	0.0	1166.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD2_k127_133724_3	1032480.MLP_07260	1.249e-13	81.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4DR3R@85009|Propionibacteriales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HFD2_k127_133724_2	204669.Acid345_0001	2.558e-101	340.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria,2JHN7@204432|Acidobacteriia	204432|Acidobacteriia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD2_k127_1342353_1	395961.Cyan7425_2954	6.636e-22	105.0	COG1493@1|root,COG1493@2|Bacteria,1G5K9@1117|Cyanobacteria	1117|Cyanobacteria	T	HPr kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1342353_0	221288.JH992901_gene3394	7.729e-59	229.0	COG0367@1|root,COG0367@2|Bacteria,1G3S7@1117|Cyanobacteria,1JJE2@1189|Stigonemataceae	1117|Cyanobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_1344838_4	204669.Acid345_4342	2.585e-64	229.0	COG3748@1|root,COG3748@2|Bacteria	2|Bacteria	S	Urate oxidase N-terminal	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD2_k127_1344838_6	926550.CLDAP_19560	6.48e-47	173.0	2EB0S@1|root,3351M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1344838_0	204669.Acid345_2051	5e-324	1011.0	COG0466@1|root,COG0466@2|Bacteria,3Y2QB@57723|Acidobacteria,2JHMJ@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD2_k127_1344838_1	204669.Acid345_0497	4.042e-170	544.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HFD2_k127_1344838_3	234267.Acid_1239	2.386e-120	398.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HAMP,Response_reg,SpoIIE
HFD2_k127_1344838_2	204669.Acid345_1547	2.438e-122	404.0	COG0389@1|root,COG0389@2|Bacteria,3Y3NY@57723|Acidobacteria,2JMMW@204432|Acidobacteriia	204432|Acidobacteriia	L	IMS family HHH motif	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD2_k127_1344838_5	240015.ACP_2650	3.293e-64	231.0	COG2890@1|root,COG2890@2|Bacteria,3Y4KU@57723|Acidobacteria,2JJCF@204432|Acidobacteriia	204432|Acidobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HFD2_k127_1345075_3	1461693.ATO10_09273	2.297e-07	59.0	COG0682@1|root,COG0682@2|Bacteria,1R7B3@1224|Proteobacteria	1224|Proteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	LGT,PAP2_3,PEMT
HFD2_k127_1345075_2	1461693.ATO10_09278	1.705e-40	160.0	2E03A@1|root,32VS4@2|Bacteria,1N4NZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1345075_1	234267.Acid_5984	2.315e-73	261.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HFD2_k127_1345075_0	234267.Acid_5844	8.587e-112	365.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HFD2_k127_1353956_1	404380.Gbem_4005	4.68e-79	276.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,42RBE@68525|delta/epsilon subdivisions,2WN7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1353956_3	316067.Geob_0950	1.46e-46	177.0	COG1309@1|root,COG1309@2|Bacteria,1NM2A@1224|Proteobacteria,42XG6@68525|delta/epsilon subdivisions,2WT4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_1353956_2	234267.Acid_5054	1.192e-55	199.0	COG2318@1|root,COG2318@2|Bacteria,3Y579@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_1353956_0	234267.Acid_7338	1.978e-181	580.0	COG1228@1|root,COG1228@2|Bacteria,3Y39J@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_1371457_1	118166.JH976537_gene3002	4.162e-101	348.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HFD2_k127_1371457_0	1267533.KB906737_gene1718	6.249e-170	551.0	COG0457@1|root,COG0457@2|Bacteria,3Y3HT@57723|Acidobacteria	57723|Acidobacteria	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD2_k127_1371457_2	1267534.KB906754_gene2899	2.674e-79	273.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria,2JKKU@204432|Acidobacteriia	204432|Acidobacteriia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_137719_2	203119.Cthe_0977	4.952e-14	75.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WH5M@541000|Ruminococcaceae	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_137719_0	240015.ACP_1089	1.162e-162	519.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria,2JIGX@204432|Acidobacteriia	204432|Acidobacteriia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD2_k127_137719_1	1382359.JIAL01000001_gene1975	1.845e-85	294.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria,2JHQF@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_1382010_2	234267.Acid_5749	1.26e-190	626.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1382010_0	234267.Acid_4431	2.211e-243	784.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1382010_1	234267.Acid_4431	4.132e-195	640.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_1382010_3	204669.Acid345_4392	1.163e-112	372.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD2_k127_1384207_1	204669.Acid345_4296	4.24e-44	165.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_1384207_0	234267.Acid_1009	9.039e-123	417.0	COG0358@1|root,COG0358@2|Bacteria,3Y366@57723|Acidobacteria	57723|Acidobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HFD2_k127_1414724_0	861299.J421_0889	3.778e-56	207.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HFD2_k127_1414724_1	1267535.KB906767_gene3597	2.465e-52	199.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HFD2_k127_1424764_1	234267.Acid_0085	3.239e-101	338.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_1424764_0	1379270.AUXF01000001_gene2101	3.978e-167	541.0	COG1473@1|root,COG1473@2|Bacteria,1ZUAX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
HFD2_k127_1430203_3	479434.Sthe_2520	7.76e-106	357.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,27Y0A@189775|Thermomicrobia	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_1430203_1	1340493.JNIF01000003_gene3892	2.974e-142	479.0	COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
HFD2_k127_1430203_8	234267.Acid_2727	3.711e-16	91.0	COG1714@1|root,COG1714@2|Bacteria,3Y5I9@57723|Acidobacteria	57723|Acidobacteria	S	pfam rdd	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HFD2_k127_1430203_5	404589.Anae109_1896	5.995e-65	227.0	COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2WMQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HFD2_k127_1430203_2	204669.Acid345_1809	2.32e-129	426.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_1430203_0	234267.Acid_6988	3.746e-171	546.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HFD2_k127_1430203_7	204669.Acid345_1811	3.684e-28	115.0	COG1146@1|root,COG1146@2|Bacteria,3Y8H9@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HFD2_k127_1430203_4	204669.Acid345_4232	1.268e-93	323.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria,2JHJK@204432|Acidobacteriia	204432|Acidobacteriia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD2_k127_1430203_6	56780.SYN_02446	1.924e-38	152.0	COG0579@1|root,COG0579@2|Bacteria	2|Bacteria	S	malate dehydrogenase (menaquinone) activity	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
HFD2_k127_1436836_0	204669.Acid345_1052	3.132e-210	679.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HFD2_k127_1436836_3	234267.Acid_1165	2.997e-122	401.0	COG2025@1|root,COG2025@2|Bacteria,3Y4SJ@57723|Acidobacteria	57723|Acidobacteria	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_1436836_6	204669.Acid345_3697	4.67e-92	310.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_1436836_1	234267.Acid_1167	1.649e-182	579.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_1436836_13	204669.Acid345_4505	2.52e-30	121.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria,2JJPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD2_k127_1436836_7	204669.Acid345_0265	3.028e-89	300.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria,2JI6U@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_1436836_5	204669.Acid345_4573	4.689e-105	350.0	COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria,2JI6J@204432|Acidobacteriia	204432|Acidobacteriia	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HFD2_k127_1436836_4	234267.Acid_6758	3.889e-119	392.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD2_k127_1436836_14	204669.Acid345_4144	7.888e-22	96.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HFD2_k127_1436836_10	1267533.KB906734_gene4286	6.745e-35	139.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria,2JJ8Y@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HFD2_k127_1436836_2	204669.Acid345_4602	3.95e-141	458.0	COG0232@1|root,COG0232@2|Bacteria,3Y2S2@57723|Acidobacteria,2JIHE@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HFD2_k127_1436836_12	1267534.KB906759_gene1849	7.364e-31	131.0	COG1729@1|root,COG1729@2|Bacteria,3Y4ME@57723|Acidobacteria,2JJA9@204432|Acidobacteriia	204432|Acidobacteriia	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HFD2_k127_1436836_9	204669.Acid345_4276	9.382e-60	232.0	COG0308@1|root,COG0308@2|Bacteria,3Y31F@57723|Acidobacteria,2JMCB@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_1436836_8	204669.Acid345_4277	4.428e-85	299.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_4277|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1436836_11	649747.HMPREF0083_03728	1.437e-32	129.0	COG0624@1|root,COG0624@2|Bacteria,1TPSM@1239|Firmicutes,4HD69@91061|Bacilli,26TVQ@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_1466152_1	204669.Acid345_1660	4.602e-73	273.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
HFD2_k127_1466152_0	1340493.JNIF01000003_gene2837	6.517e-105	345.0	COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_1466152_2	204669.Acid345_1662	4.519e-46	172.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria,2JIY6@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD2_k127_1473711_0	1121403.AUCV01000020_gene3105	4.303e-124	406.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42NE7@68525|delta/epsilon subdivisions,2WJ77@28221|Deltaproteobacteria,2MM3R@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_1473711_1	301.JNHE01000009_gene3394	7.646e-12	75.0	COG3182@1|root,COG3182@2|Bacteria,1MUX8@1224|Proteobacteria,1S33A@1236|Gammaproteobacteria,1YH85@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HFD2_k127_1488825_4	32057.KB217478_gene7158	9.358e-21	99.0	COG2208@1|root,COG2208@2|Bacteria,1G160@1117|Cyanobacteria,1HMW2@1161|Nostocales	1117|Cyanobacteria	KT	Stage II sporulation protein E (SpoIIE)	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PilJ,SpoIIE
HFD2_k127_1488825_5	794846.AJQU01000079_gene5632	2.373e-14	82.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,4BFWW@82115|Rhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD2_k127_1488825_0	1267535.KB906767_gene2891	5.382e-98	354.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K03407,ko:K07678	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00475,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HFD2_k127_1488825_3	1496688.ER33_10485	3.199e-24	120.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,22SQM@167375|Cyanobium	1117|Cyanobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS,PAS_3,PAS_9,Response_reg
HFD2_k127_1488825_2	1173026.Glo7428_2204	2.28e-57	203.0	COG0784@1|root,COG0784@2|Bacteria,1GQ4W@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM response regulator receiveR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_1488825_1	1123508.JH636449_gene7420	8.592e-92	311.0	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,2IZ70@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
HFD2_k127_1525077_1	1123371.ATXH01000005_gene2046	1.563e-64	230.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_1525077_0	1267533.KB906735_gene5030	1.116e-72	257.0	COG1215@1|root,COG1215@2|Bacteria,3Y3PN@57723|Acidobacteria,2JHSE@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1525077_2	426117.M446_0469	1.311e-17	83.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TU0N@28211|Alphaproteobacteria,1JSI3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	MA20_23565	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD2_k127_1528633_0	479434.Sthe_3117	7.086e-172	554.0	COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glycosyl hydrolase BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_1528633_1	378806.STAUR_4753	6.398e-72	252.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_1534315_5	1128421.JAGA01000003_gene3421	2.2e-35	140.0	COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria	2|Bacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HFD2_k127_1534315_4	1280390.CBQR020000101_gene2384	5.575e-46	175.0	COG0125@1|root,COG0125@2|Bacteria,1V2D5@1239|Firmicutes	1239|Firmicutes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680	Thymidylate_kin
HFD2_k127_1534315_3	240015.ACP_2987	1.724e-60	222.0	COG2812@1|root,COG2812@2|Bacteria,3Y3C1@57723|Acidobacteria,2JI0U@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HFD2_k127_1534315_7	234267.Acid_0132	1.365e-30	129.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria	57723|Acidobacteria	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
HFD2_k127_1534315_8	338966.Ppro_1137	3.726e-25	109.0	COG2050@1|root,COG2050@2|Bacteria,1PP3U@1224|Proteobacteria,43E7M@68525|delta/epsilon subdivisions,2X2FF@28221|Deltaproteobacteria,43V5X@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Thioesterase-like superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HFD2_k127_1534315_2	479434.Sthe_2896	9.661e-66	234.0	COG1028@1|root,COG1028@2|Bacteria,2G6IK@200795|Chloroflexi,27Y50@189775|Thermomicrobia	200795|Chloroflexi	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1534315_0	204669.Acid345_4031	2.179e-157	507.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_1534315_1	204669.Acid345_3283	1.5e-94	320.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,3Y4K4@57723|Acidobacteria,2JMIM@204432|Acidobacteriia	204432|Acidobacteriia	P	TrkA-C domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HFD2_k127_1534315_6	797114.C475_09434	8.77e-35	143.0	arCOG11971@1|root,arCOG11971@2157|Archaea,2XWIZ@28890|Euryarchaeota,23VA2@183963|Halobacteria	183963|Halobacteria	S	YndJ-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YndJ
HFD2_k127_1557797_2	572547.Amico_0513	1.83e-08	65.0	COG1013@1|root,COG1013@2|Bacteria,3TA5J@508458|Synergistetes	508458|Synergistetes	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_1557797_1	156889.Mmc1_1564	4.477e-23	107.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_1557797_0	234267.Acid_4539	3.16e-188	597.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HFD2_k127_1559492_1	1267534.KB906754_gene3808	6.343e-133	437.0	COG2848@1|root,COG2848@2|Bacteria,3Y7DW@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HFD2_k127_1559492_3	1121015.N789_00340	7.749e-08	61.0	2EJ52@1|root,33CW9@2|Bacteria,1PD05@1224|Proteobacteria,1SY6A@1236|Gammaproteobacteria,1X79D@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1559492_0	1300345.LF41_2250	2.971e-266	845.0	COG0823@1|root,COG0823@2|Bacteria,1R1F4@1224|Proteobacteria,1T0CM@1236|Gammaproteobacteria,1X5C1@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_1559492_2	1459636.NTE_02118	7.737e-21	96.0	arCOG07802@1|root,arCOG07802@2157|Archaea	2157|Archaea	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255,F420H2_quin_red
HFD2_k127_1560441_3	1303518.CCALI_00534	1.876e-23	101.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_1560441_1	598467.BrE312_2845	8.299e-41	155.0	COG1310@1|root,COG1310@2|Bacteria,1QRZQ@1224|Proteobacteria,1S558@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HFD2_k127_1560441_2	1183438.GKIL_0678	2.115e-32	128.0	COG1977@1|root,COG1977@2|Bacteria,1GFB9@1117|Cyanobacteria	1117|Cyanobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD2_k127_1560441_0	234267.Acid_0755	2.209e-139	451.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria	57723|Acidobacteria	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
HFD2_k127_156440_3	234267.Acid_2159	0.0001261	51.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
HFD2_k127_156440_0	234267.Acid_2159	1.728e-91	317.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,3Y2P9@57723|Acidobacteria	57723|Acidobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
HFD2_k127_156440_2	1379698.RBG1_1C00001G0926	3.986e-52	193.0	COG1028@1|root,COG1028@2|Bacteria,2NPQY@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_156440_1	234267.Acid_2158	1.616e-82	286.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_1573645_1	35754.JNYJ01000014_gene4761	3.728e-40	152.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD2_k127_1573645_0	1267535.KB906767_gene3577	1.054e-47	192.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_1573645_2	316067.Geob_0611	5.039e-25	108.0	COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2X6IT@28221|Deltaproteobacteria,43UX0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD2_k127_1587248_3	204669.Acid345_0042	1.071e-29	135.0	COG0357@1|root,COG0357@2|Bacteria,3Y4W7@57723|Acidobacteria,2JJG7@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD2_k127_1587248_5	1146883.BLASA_2248	3.173e-09	66.0	COG1266@1|root,COG1266@2|Bacteria,2IS6T@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HFD2_k127_1587248_6	1463887.KL590055_gene6455	3.297e-08	68.0	COG0457@1|root,COG0457@2|Bacteria,2IC53@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_1587248_1	290397.Adeh_3062	4.562e-104	376.0	COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2YUT9@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HFD2_k127_1587248_0	289377.HL41_01295	4.798e-122	409.0	COG0151@1|root,COG0151@2|Bacteria,2GGTX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
HFD2_k127_1587248_4	378806.STAUR_1745	1.964e-29	125.0	COG2258@1|root,COG2258@2|Bacteria,1RIAF@1224|Proteobacteria,42RG1@68525|delta/epsilon subdivisions,2WNX7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HFD2_k127_1587248_2	1255043.TVNIR_3388	2.316e-41	160.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD2_k127_1624520_22	1037409.BJ6T_19870	1.523e-22	100.0	2E95S@1|root,333EG@2|Bacteria,1NBCB@1224|Proteobacteria,2UMYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1624520_4	1232410.KI421428_gene1054	1.392e-149	488.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_1624520_8	204669.Acid345_0750	4.303e-123	404.0	COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria,2JJS0@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_1624520_16	321332.CYB_0987	1.555e-52	202.0	COG0642@1|root,COG2205@2|Bacteria,1FZZD@1117|Cyanobacteria,1GZSQ@1129|Synechococcus	1117|Cyanobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_3,HATPase_c,HisKA
HFD2_k127_1624520_20	388467.A19Y_2731	1.531e-26	115.0	COG0784@1|root,COG0784@2|Bacteria,1G5VY@1117|Cyanobacteria,1HB3F@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	divK	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_1624520_15	204669.Acid345_2506	4.881e-80	276.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD2_k127_1624520_7	204669.Acid345_3827	1.224e-128	442.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria,2JI2I@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1624520_11	204669.Acid345_3828	5.096e-105	350.0	COG3303@1|root,COG3303@2|Bacteria,3Y999@57723|Acidobacteria,2JP5G@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HFD2_k127_1624520_3	204669.Acid345_0749	1.154e-177	567.0	COG0755@1|root,COG0755@2|Bacteria,3Y3QF@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HFD2_k127_1624520_5	204669.Acid345_0748	2.06e-141	465.0	COG1333@1|root,COG1333@2|Bacteria,3Y7QW@57723|Acidobacteria	57723|Acidobacteria	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
HFD2_k127_1624520_24	46429.BV95_02814	6.137e-07	57.0	COG4566@1|root,COG4566@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_1624520_21	158190.SpiGrapes_2343	1.817e-23	108.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_1624520_23	639030.JHVA01000001_gene3979	7.962e-15	79.0	COG2010@1|root,COG2010@2|Bacteria,3Y9G7@57723|Acidobacteria,2JNPI@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_1624520_17	671143.DAMO_0820	1.083e-40	156.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HFD2_k127_1624520_6	1379698.RBG1_1C00001G0780	2.796e-139	451.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HFD2_k127_1624520_9	671143.DAMO_0822	9.512e-109	377.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HFD2_k127_1624520_2	1121920.AUAU01000018_gene1826	6.564e-198	635.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD2_k127_1624520_0	1379698.RBG1_1C00001G0777	8.871e-242	766.0	COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HFD2_k127_1624520_10	1379698.RBG1_1C00001G0777	2.385e-105	352.0	COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HFD2_k127_1624520_1	1121920.AUAU01000001_gene2268	6.913e-227	722.0	COG2864@1|root,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
HFD2_k127_1624520_12	1196031.ALEG01000039_gene1395	1.494e-96	329.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4IRCI@91061|Bacilli,1ZNCI@1386|Bacillus	91061|Bacilli	E	Ornithine cyclodeaminase/mu-crystallin family	sbnB	-	1.5.1.51	ko:K21721	-	-	-	-	ko00000,ko01000	-	-	iSB619.SA_RS00720	OCD_Mu_crystall
HFD2_k127_1624520_14	1267535.KB906767_gene2661	9.377e-83	282.0	COG1573@1|root,COG1573@2|Bacteria,3Y4AT@57723|Acidobacteria,2JJ4U@204432|Acidobacteriia	204432|Acidobacteriia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_1624520_13	861299.J421_0232	3.483e-83	289.0	COG3055@1|root,COG3055@2|Bacteria,1ZUV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
HFD2_k127_1624520_19	485917.Phep_2981	3.434e-27	125.0	COG3391@1|root,COG5492@1|root,COG3391@2|Bacteria,COG5492@2|Bacteria,4PMF3@976|Bacteroidetes,1IT6W@117747|Sphingobacteriia	976|Bacteroidetes	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHU_C,VCBS
HFD2_k127_1624520_18	234267.Acid_5134	1.524e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1661218_1	1894.JOER01000058_gene3221	6.696e-21	97.0	COG0265@1|root,COG2319@1|root,COG0265@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,WD40
HFD2_k127_1661218_0	234267.Acid_2875	8.624e-104	346.0	COG3844@1|root,COG3844@2|Bacteria,3Y984@57723|Acidobacteria	57723|Acidobacteria	F	Aminotransferase class-V	-	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HFD2_k127_1693778_3	234267.Acid_7219	1.556e-53	191.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_1693778_1	41431.PCC8801_0005	1.883e-91	306.0	COG2020@1|root,COG2020@2|Bacteria,1G4HN@1117|Cyanobacteria,3KGIV@43988|Cyanothece	1117|Cyanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HFD2_k127_1693778_0	666685.R2APBS1_1154	2.43e-185	594.0	COG3055@1|root,COG3055@2|Bacteria,1NHAC@1224|Proteobacteria,1RYBY@1236|Gammaproteobacteria,1XAGU@135614|Xanthomonadales	135614|Xanthomonadales	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1693778_5	204669.Acid345_0690	2.736e-22	102.0	2EQJB@1|root,33I5C@2|Bacteria,3Y5WN@57723|Acidobacteria,2JNK1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1693778_2	378806.STAUR_7416	3.077e-81	279.0	COG3217@1|root,COG3217@2|Bacteria,1N1P0@1224|Proteobacteria,43024@68525|delta/epsilon subdivisions,2X3J5@28221|Deltaproteobacteria,2YWAG@29|Myxococcales	28221|Deltaproteobacteria	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HFD2_k127_1693778_4	1267211.KI669560_gene2123	3.443e-45	167.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1INWN@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family M28	PGCP	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_1718253_1	204669.Acid345_2022	1.073e-77	263.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria,2JISM@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_1718253_2	1210884.HG799462_gene8786	2.242e-35	142.0	COG0346@1|root,COG4319@1|root,COG0346@2|Bacteria,COG4319@2|Bacteria,2J0KT@203682|Planctomycetes	203682|Planctomycetes	E	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_1718253_0	1267535.KB906767_gene4085	5.078e-129	421.0	COG1015@1|root,COG1015@2|Bacteria,3Y6GB@57723|Acidobacteria	57723|Acidobacteria	G	Metalloenzyme superfamily	-	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HFD2_k127_172032_9	1267534.KB906754_gene3056	4.084e-06	56.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD2_k127_172032_12	1218074.BAXZ01000015_gene3128	0.0005378	48.0	2BGXF@1|root,32AXE@2|Bacteria,1PXHQ@1224|Proteobacteria,2WCXJ@28216|Betaproteobacteria,1K8P8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_172032_0	204669.Acid345_1474	1.214e-170	547.0	COG1113@1|root,COG1113@2|Bacteria	2|Bacteria	E	amino acid transport	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_172032_2	204669.Acid345_1475	6.185e-107	377.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD2_k127_172032_3	234267.Acid_1969	6.301e-107	363.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria	2|Bacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_172032_6	1238182.C882_2113	1.281e-16	93.0	COG5455@1|root,COG5455@2|Bacteria,1N3PU@1224|Proteobacteria,2UGK9@28211|Alphaproteobacteria,2JUR7@204441|Rhodospirillales	204441|Rhodospirillales	S	response to cobalt ion	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_172032_5	1382359.JIAL01000001_gene1843	1.318e-22	112.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_172032_7	204669.Acid345_1582	1.338e-11	68.0	2EEIP@1|root,338CM@2|Bacteria,3Y5Q1@57723|Acidobacteria,2JK0Z@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_172032_10	761193.Runsl_3205	8.696e-05	53.0	COG4319@1|root,COG4319@2|Bacteria,4NS9D@976|Bacteroidetes,47R8I@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_172032_1	118173.KB235914_gene497	1.243e-110	366.0	COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,1H82Z@1150|Oscillatoriales	1117|Cyanobacteria	C	galactose-1-phosphate	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf,HIT
HFD2_k127_172032_4	234267.Acid_2151	3.844e-69	254.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	2|Bacteria	S	PFAM LmbE family protein	mca	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	NPCBM_assoc,PIG-L
HFD2_k127_1724812_1	443143.GM18_1682	2.514e-27	117.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria	1224|Proteobacteria	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_1724812_2	1122971.BAME01000065_gene4761	7.105e-22	109.0	COG3746@1|root,COG3746@2|Bacteria,4NIID@976|Bacteroidetes,2FN19@200643|Bacteroidia,22Z0H@171551|Porphyromonadaceae	976|Bacteroidetes	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4,Porin_O_P
HFD2_k127_1724812_0	204669.Acid345_0825	1.112e-127	417.0	COG0715@1|root,COG0715@2|Bacteria,3Y5UN@57723|Acidobacteria,2JNY2@204432|Acidobacteriia	204432|Acidobacteriia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD2_k127_1737805_5	1108045.GORHZ_121_00080	4.621e-27	128.0	COG1807@1|root,COG1807@2|Bacteria,2IB2Q@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_1737805_1	234267.Acid_5675	1.571e-141	457.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria	57723|Acidobacteria	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD2_k127_1737805_3	204669.Acid345_0037	3.306e-97	346.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HFD2_k127_1737805_6	1121272.KB903255_gene5684	1.036e-11	70.0	COG0346@1|root,COG0346@2|Bacteria,2HUMQ@201174|Actinobacteria,4DFH8@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_1737805_0	1267534.KB906758_gene2303	4.912e-256	835.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Y@57723|Acidobacteria,2JKVG@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_1737805_2	1121430.JMLG01000019_gene1656	5.33e-101	344.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae	186801|Clostridia	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD2_k127_1784957_5	861299.J421_5727	2.389e-26	114.0	COG3832@1|root,COG3832@2|Bacteria,1ZU6N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_1784957_6	391038.Bphy_1819	1.837e-17	92.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2WEZ2@28216|Betaproteobacteria,1KHXR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_1784957_4	483219.LILAB_30740	9.831e-31	127.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,430Y1@68525|delta/epsilon subdivisions,2WVU4@28221|Deltaproteobacteria,2YVFD@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_1784957_2	240015.ACP_0762	4.041e-60	214.0	COG0807@1|root,COG0807@2|Bacteria,3Y2I4@57723|Acidobacteria,2JHSG@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HFD2_k127_1784957_0	204669.Acid345_4032	5.036e-111	374.0	COG2972@1|root,COG2972@2|Bacteria,3Y3NH@57723|Acidobacteria,2JHT4@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,His_kinase
HFD2_k127_1784957_3	714943.Mucpa_7131	1.564e-35	141.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
HFD2_k127_1784957_9	215803.DB30_3835	2.65e-08	61.0	28QQ1@1|root,2ZD5J@2|Bacteria,1QPY8@1224|Proteobacteria,439MX@68525|delta/epsilon subdivisions,2X4Z5@28221|Deltaproteobacteria,2YZVK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1784957_1	1502852.FG94_00959	8.046e-61	215.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,2VQNT@28216|Betaproteobacteria,4742C@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_1784957_8	710685.MycrhN_4933	3.085e-09	63.0	COG3011@1|root,COG3011@2|Bacteria,2HS35@201174|Actinobacteria,23ABV@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HFD2_k127_1784957_7	269798.CHU_3112	1.629e-09	67.0	2DS4P@1|root,33EH8@2|Bacteria,4PPZ4@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1786503_2	251221.35211765	2.134e-195	636.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1786503_1	251221.35211983	4.602e-209	676.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1786503_4	1233950.IW22_09585	2.507e-24	110.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I2SV@117743|Flavobacteriia,3ZS3U@59732|Chryseobacterium	976|Bacteroidetes	J	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD2_k127_1786503_3	1183438.GKIL_2517	1.835e-134	440.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1786503_0	1485544.JQKP01000008_gene1704	1.485e-227	715.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,44VKX@713636|Nitrosomonadales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HFD2_k127_1799287_0	1267533.KB906736_gene1246	7.347e-227	727.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_1799287_2	204669.Acid345_4457	6.308e-107	370.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	zraS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HFD2_k127_1799287_1	204669.Acid345_3570	6.382e-115	376.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria,2JINE@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1799287_3	1267534.KB906754_gene2746	5.913e-55	213.0	2DC1Z@1|root,2ZCIM@2|Bacteria,3Y4F2@57723|Acidobacteria,2JJ0Y@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HFD2_k127_1799287_4	479432.Sros_4819	1.137e-48	175.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4ENBU@85012|Streptosporangiales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HFD2_k127_1865663_0	760192.Halhy_0227	3.433e-85	300.0	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1IT3V@117747|Sphingobacteriia	976|Bacteroidetes	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,SusF_SusE
HFD2_k127_186578_1	1550073.JROH01000012_gene2472	8.286e-15	87.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2U4MG@28211|Alphaproteobacteria,2JZXB@204457|Sphingomonadales	204457|Sphingomonadales	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_186578_0	234267.Acid_5560	8.227e-77	271.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,TPR_15,TPR_16,TPR_4,TPR_8
HFD2_k127_190961_3	1267533.KB906733_gene2849	2.597e-24	102.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_190961_0	204669.Acid345_2130	2.194e-160	520.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
HFD2_k127_190961_1	1382359.JIAL01000001_gene2085	1.785e-126	417.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_190961_2	1294143.H681_04140	1.487e-25	109.0	COG0702@1|root,COG0702@2|Bacteria,1PGSR@1224|Proteobacteria	1224|Proteobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
HFD2_k127_1914638_7	1267535.KB906767_gene4385	6.163e-15	78.0	2CK96@1|root,3346F@2|Bacteria,3Y5N2@57723|Acidobacteria,2JJZD@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1914638_4	665571.STHERM_c03350	7.35e-44	167.0	COG2078@1|root,COG2078@2|Bacteria,2J7B9@203691|Spirochaetes	203691|Spirochaetes	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HFD2_k127_1914638_3	234267.Acid_6304	2.675e-57	209.0	COG0558@1|root,COG0558@2|Bacteria,3Y520@57723|Acidobacteria	57723|Acidobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_1914638_6	29581.BW37_04425	1.024e-20	94.0	2EK70@1|root,33DXD@2|Bacteria,1NA99@1224|Proteobacteria,2WCK9@28216|Betaproteobacteria,477U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1914638_0	760568.Desku_0259	2.798e-108	366.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,2606G@186807|Peptococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD2_k127_1914638_2	204669.Acid345_4559	4.396e-80	281.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria,2JICH@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD2_k127_1914638_5	1340493.JNIF01000003_gene3597	2.095e-22	112.0	COG0810@1|root,COG0810@2|Bacteria,3Y3T5@57723|Acidobacteria	57723|Acidobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2,TonB_C
HFD2_k127_1914638_1	401053.AciPR4_0101	7.642e-82	280.0	COG0673@1|root,COG0673@2|Bacteria,3Y3ET@57723|Acidobacteria,2JHRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_1922696_1	1382359.JIAL01000001_gene699	3.043e-60	217.0	COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria,2JHJA@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HFD2_k127_1922696_0	1121930.AQXG01000003_gene2618	1.254e-121	405.0	COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes	976|Bacteroidetes	V	ABC transporter	mdlA	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HFD2_k127_1935241_2	926566.Terro_0306	1.451e-23	108.0	COG2825@1|root,COG2825@2|Bacteria,3Y4WC@57723|Acidobacteria,2JJHF@204432|Acidobacteriia	204432|Acidobacteriia	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD2_k127_1935241_1	204669.Acid345_4219	1.576e-37	147.0	COG0779@1|root,COG0779@2|Bacteria,3Y528@57723|Acidobacteria,2JJHJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD2_k127_1935241_0	1382359.JIAL01000001_gene1875	8.441e-167	539.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria,2JIAX@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HFD2_k127_1935241_3	682795.AciX8_0680	1.122e-10	70.0	COG0532@1|root,COG0532@2|Bacteria,3Y3UG@57723|Acidobacteria,2JHXH@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
HFD2_k127_1939304_1	1267534.KB906755_gene4272	5.414e-78	268.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	AAA_19,Ank,Ank_2,Ank_3,Ank_4,Ank_5,Sigma70_r2,Sigma70_r4,Viral_helicase1
HFD2_k127_1939304_3	329726.AM1_G0157	3.353e-35	139.0	COG0346@1|root,COG0346@2|Bacteria,1GG65@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_1939304_0	1128421.JAGA01000003_gene2871	4.266e-216	678.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HFD2_k127_1939304_2	204669.Acid345_3004	4.655e-65	226.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD2_k127_1943010_2	234267.Acid_6570	5.702e-62	237.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_6570|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1943010_0	251221.35211765	1.246e-204	664.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1943010_1	1183438.GKIL_4354	1.311e-73	259.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1955444_4	234267.Acid_2315	9.788e-52	203.0	COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria	57723|Acidobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_1955444_1	1356852.N008_09540	1.057e-160	518.0	COG0531@1|root,COG0531@2|Bacteria,4NIB8@976|Bacteroidetes,47MKD@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_1955444_2	485913.Krac_11193	3.606e-94	323.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi	200795|Chloroflexi	E	homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_1955444_5	1183438.GKIL_4142	2.126e-50	182.0	COG0251@1|root,COG0251@2|Bacteria,1G71N@1117|Cyanobacteria	1117|Cyanobacteria	J	translation initiation inhibitor, yjgF family	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_1955444_7	93612.XP_008023547.1	8.456e-05	46.0	COG0626@1|root,KOG0053@2759|Eukaryota,38CST@33154|Opisthokonta,3NU9U@4751|Fungi,3QMB7@4890|Ascomycota,2000Q@147541|Dothideomycetes,4KEQI@92860|Pleosporales	4751|Fungi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	CYS3	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019343,GO:0019344,GO:0019346,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0050667,GO:0070279,GO:0071265,GO:0071266,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HFD2_k127_1955444_6	1054213.HMPREF9946_03239	2.962e-29	124.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,2JYMX@204441|Rhodospirillales	204441|Rhodospirillales	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1955444_3	1267534.KB906760_gene1540	4.257e-58	216.0	COG2199@1|root,COG4191@1|root,COG5002@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	kinE	-	2.7.13.3,3.1.3.3,4.6.1.1	ko:K01768,ko:K02482,ko:K02491,ko:K07315,ko:K13533,ko:K14986,ko:K20977	ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213	M00485,M00524,M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021	-	-	-	GAF,HATPase_c,HATPase_c_2,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SpoIIE
HFD2_k127_1955444_0	1267534.KB906760_gene1541	0.0	1762.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG1511@1|root,COG2770@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria	2|Bacteria	T	Histidine kinase	MA20_07280	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HFD2_k127_1966414_2	234267.Acid_4195	3.06e-15	80.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,3Y6CI@57723|Acidobacteria	57723|Acidobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_1966414_4	204669.Acid345_2019	0.0001533	51.0	2CKY5@1|root,32WNR@2|Bacteria,3Y5B7@57723|Acidobacteria,2JJTK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1966414_1	234267.Acid_7049	3.39e-41	164.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria	57723|Acidobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1966414_3	1267533.KB906736_gene927	2.317e-06	55.0	COG3063@1|root,COG3063@2|Bacteria,3Y5SX@57723|Acidobacteria,2JP2Y@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1966414_0	234267.Acid_6644	1.65e-211	667.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HFD2_k127_196701_1	278963.ATWD01000001_gene3128	4.344e-61	227.0	COG2234@1|root,COG2234@2|Bacteria,3Y80U@57723|Acidobacteria,2JNYW@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_196701_2	326427.Cagg_3818	1.288e-30	126.0	COG3703@1|root,COG3703@2|Bacteria,2GBRN@200795|Chloroflexi,376AK@32061|Chloroflexia	32061|Chloroflexia	P	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
HFD2_k127_196701_0	246194.CHY_1607	7.671e-107	354.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,24C0I@186801|Clostridia,42HWH@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1967425_0	1382359.JIAL01000001_gene1344	4.956e-155	500.0	COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria,2JIVG@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1967425_1	682795.AciX8_2036	2.281e-05	51.0	COG0711@1|root,COG0711@2|Bacteria,3Y4WK@57723|Acidobacteria,2JJH3@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the ATPase B chain family	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_1993393_3	134676.ACPL_6364	8.041e-12	66.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4DBAC@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HFD2_k127_1993393_0	1382359.JIAL01000001_gene1578	1.626e-124	403.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria,2JHZZ@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_1993393_4	29306.JOBE01000046_gene6055	3.055e-05	53.0	COG3832@1|root,COG3832@2|Bacteria,2IHQS@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_1993393_1	1227739.Hsw_2994	3.184e-53	197.0	COG5429@1|root,COG5429@2|Bacteria,4NNGV@976|Bacteroidetes,47RAT@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HFD2_k127_1993393_2	1121405.dsmv_1091	2.192e-25	113.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2MJNU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
HFD2_k127_1998688_2	1121468.AUBR01000045_gene1811	2.653e-125	411.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,42EYR@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD2_k127_1998688_3	240015.ACP_2205	2.624e-121	396.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia	204432|Acidobacteriia	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_1998688_0	1267535.KB906767_gene5021	1.156e-184	586.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria,2JI7K@204432|Acidobacteriia	204432|Acidobacteriia	J	class II (D K	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_1998688_6	234267.Acid_2806	1.875e-60	219.0	COG1082@1|root,COG1082@2|Bacteria,3Y4EN@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_1998688_1	661478.OP10G_1956	8.152e-146	482.0	COG0405@1|root,COG0405@2|Bacteria	2|Bacteria	E	Gamma-glutamyltransferase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_1998688_9	1038867.AXAY01000021_gene2274	1.257e-38	148.0	COG3744@1|root,COG3744@2|Bacteria,1N0J5@1224|Proteobacteria,2UDVP@28211|Alphaproteobacteria,3K4GE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_1998688_11	1121033.AUCF01000031_gene124	5.365e-20	91.0	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,2UFRK@28211|Alphaproteobacteria,2JUQG@204441|Rhodospirillales	204441|Rhodospirillales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_1998688_4	1379698.RBG1_1C00001G1220	1.078e-116	384.0	COG0620@1|root,COG0620@2|Bacteria,2NPAE@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131	Meth_synt_1,Meth_synt_2
HFD2_k127_1998688_8	515635.Dtur_1756	2.172e-55	212.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
HFD2_k127_1998688_5	1267533.KB906737_gene1612	2.683e-99	333.0	COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria,2JIDE@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HFD2_k127_1998688_7	251221.35211984	1.606e-57	214.0	2EA12@1|root,3346D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HFD2_k127_1998688_10	525904.Tter_2689	2.271e-38	152.0	COG1268@1|root,COG1268@2|Bacteria,2NPGG@2323|unclassified Bacteria	2|Bacteria	S	BioY family	bioY	-	-	ko:K02014,ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	1.B.14,2.A.88.1,2.A.88.2	-	-	BioY
HFD2_k127_1998688_13	204669.Acid345_1569	7.413e-08	63.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD2_k127_2025797_0	523791.Kkor_2389	2.9e-135	452.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1XP2X@135619|Oceanospirillales	135619|Oceanospirillales	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_2025797_1	234267.Acid_5050	3.166e-99	338.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Big_2,F5_F8_type_C,Glyco_hydro_98C,Glyco_hydro_98M,NPCBM,Peptidase_M16,Peptidase_M16_C
HFD2_k127_2025797_2	1267533.KB906737_gene1824	0.0003328	44.0	COG2823@1|root,COG2823@2|Bacteria,3Y7TZ@57723|Acidobacteria,2JN17@204432|Acidobacteriia	204432|Acidobacteriia	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_2060648_3	1479237.JMLY01000001_gene2560	6.996e-07	60.0	2F4QX@1|root,33XDX@2|Bacteria,1NX38@1224|Proteobacteria,1SPCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HFD2_k127_2060648_2	204669.Acid345_0678	9.282e-95	326.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	yagE	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_2060648_1	234267.Acid_6682	7.211e-144	463.0	COG1294@1|root,COG1294@2|Bacteria,3Y3UT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HFD2_k127_2060648_0	234267.Acid_6681	1.962e-199	627.0	COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HFD2_k127_2061932_10	639030.JHVA01000001_gene427	1.453e-21	95.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria,2JIJ3@204432|Acidobacteriia	204432|Acidobacteriia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD2_k127_2061932_9	1121920.AUAU01000005_gene959	6.862e-22	108.0	2E0D8@1|root,32W02@2|Bacteria,3Y5V4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2061932_8	204669.Acid345_1716	1.332e-29	126.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria,2JJ4E@204432|Acidobacteriia	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_2061932_7	1230342.CTM_18261	7.247e-33	133.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,25ESC@186801|Clostridia,36USA@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_2061932_11	1382359.JIAL01000001_gene2629	2.572e-13	78.0	COG0695@1|root,COG0695@2|Bacteria,3Y8TH@57723|Acidobacteria,2JNX4@204432|Acidobacteriia	204432|Acidobacteriia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HFD2_k127_2061932_1	1304875.JAFZ01000002_gene341	7.157e-120	393.0	COG1313@1|root,COG1313@2|Bacteria,3TB2M@508458|Synergistetes	508458|Synergistetes	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HFD2_k127_2061932_4	1121957.ATVL01000008_gene4145	7.454e-56	216.0	COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,47P2Z@768503|Cytophagia	976|Bacteroidetes	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM
HFD2_k127_2061932_3	1379270.AUXF01000003_gene3745	6.846e-61	225.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_2061932_0	861299.J421_1109	1.09e-303	943.0	COG1132@1|root,COG1132@2|Bacteria,1ZUSI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_2061932_5	1304284.L21TH_0927	2.1e-38	148.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,36HZ3@31979|Clostridiaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD2_k127_2061932_6	215803.DB30_2394	2.784e-36	141.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2YV9P@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HFD2_k127_2061932_2	204669.Acid345_0563	1.409e-108	358.0	COG0052@1|root,COG0052@2|Bacteria,3Y3K2@57723|Acidobacteria,2JI0A@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD2_k127_2065044_1	1267535.KB906767_gene924	3.359e-48	183.0	COG3359@1|root,COG3359@2|Bacteria,3Y6WT@57723|Acidobacteria	57723|Acidobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HFD2_k127_2065044_0	234267.Acid_0769	5.927e-299	934.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,3Y61D@57723|Acidobacteria	57723|Acidobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HFD2_k127_2093757_0	344747.PM8797T_06205	4.389e-238	751.0	COG2936@1|root,COG2936@2|Bacteria,2J2G5@203682|Planctomycetes	203682|Planctomycetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD2_k127_2097179_1	867845.KI911784_gene2016	1.434e-49	195.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi,376EU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_2097179_0	234267.Acid_1055	6.8e-99	330.0	COG0277@1|root,COG0277@2|Bacteria,3Y68N@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_2128804_1	204669.Acid345_1270	1.56e-129	415.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HFD2_k127_2128804_0	204669.Acid345_1271	1.86e-138	455.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HFD2_k127_2130053_6	639030.JHVA01000001_gene1614	1.514e-07	57.0	2DQQZ@1|root,3386A@2|Bacteria,3Y8FB@57723|Acidobacteria,2JNNB@204432|Acidobacteriia	204432|Acidobacteriia	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
HFD2_k127_2130053_1	401526.TcarDRAFT_1563	1.636e-137	459.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_2130053_7	391625.PPSIR1_33866	1.119e-05	52.0	COG3215@1|root,COG3215@2|Bacteria,1QZU1@1224|Proteobacteria,43CP3@68525|delta/epsilon subdivisions,2X7WD@28221|Deltaproteobacteria,2Z2BM@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HFD2_k127_2130053_4	1122925.KB895380_gene4126	2.591e-50	190.0	COG4221@1|root,COG4221@2|Bacteria,1TQDY@1239|Firmicutes,4HBS5@91061|Bacilli,2775M@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_2130053_5	1267534.KB906756_gene507	4.362e-38	147.0	COG1846@1|root,COG1846@2|Bacteria,3Y5M8@57723|Acidobacteria	57723|Acidobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_2130053_3	1267534.KB906756_gene506	6.475e-62	226.0	293J8@1|root,2ZR19@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2130053_2	234267.Acid_6501	1.745e-69	247.0	COG2897@1|root,COG2897@2|Bacteria,3Y7T0@57723|Acidobacteria	57723|Acidobacteria	M	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD2_k127_2130053_0	661478.OP10G_4149	6.599e-180	581.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD2_k127_2188279_0	204669.Acid345_4697	2.434e-223	700.0	COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria,2JIBH@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_2188279_3	278963.ATWD01000001_gene3375	1.789e-19	95.0	2EN0M@1|root,33FNU@2|Bacteria,3Y60X@57723|Acidobacteria,2JJZX@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2188279_1	1191523.MROS_1726	6.403e-84	284.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_2188279_2	926569.ANT_13710	5.923e-83	284.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HFD2_k127_2211109_1	648996.Theam_1725	1.79e-58	212.0	COG0134@1|root,COG0134@2|Bacteria,2G3YD@200783|Aquificae	200783|Aquificae	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HFD2_k127_2211109_2	247490.KSU1_D0595	2.853e-55	216.0	COG0265@1|root,COG0265@2|Bacteria,2J23K@203682|Planctomycetes	203682|Planctomycetes	OT	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin_2
HFD2_k127_2211109_4	76869.PputGB1_2598	7.147e-10	72.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1YUUK@136845|Pseudomonas putida group	1236|Gammaproteobacteria	K	Two component transcriptional regulator, winged helix family	lrpR	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2211109_3	234267.Acid_5135	2.017e-50	191.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Z3@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2211109_0	1267535.KB906767_gene5125	8.707e-63	229.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria	57723|Acidobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2229650_4	258533.BN977_04198	2.859e-15	85.0	COG0644@1|root,COG0644@2|Bacteria,2GM2M@201174|Actinobacteria,234A4@1762|Mycobacteriaceae	201174|Actinobacteria	C	FAD dependent oxidoreductase	srsC	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored
HFD2_k127_2229650_3	1172186.KB911466_gene1473	3.054e-33	144.0	COG1755@1|root,COG1755@2|Bacteria,2IG52@201174|Actinobacteria,238M7@1762|Mycobacteriaceae	201174|Actinobacteria	S	Isoprenylcysteine carboxyl methyltransferase	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
HFD2_k127_2229650_1	1128421.JAGA01000002_gene588	8.818e-79	277.0	COG3424@1|root,COG3424@2|Bacteria,2NPHJ@2323|unclassified Bacteria	2|Bacteria	Q	Chalcone and stilbene synthases, C-terminal domain	bcsA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HFD2_k127_2229650_2	234267.Acid_7166	1.141e-45	172.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_2229650_5	1266925.JHVX01000007_gene2276	1.183e-06	53.0	COG0236@1|root,COG0236@2|Bacteria,1PW23@1224|Proteobacteria,2WBNK@28216|Betaproteobacteria,373GP@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD2_k127_2229650_0	234267.Acid_0743	9.339e-149	478.0	COG0304@1|root,COG0304@2|Bacteria,3Y2NT@57723|Acidobacteria	57723|Acidobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_2262363_3	204669.Acid345_3834	1.973e-59	208.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria,2JITG@204432|Acidobacteriia	2|Bacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C,MR_MLE_C,MR_MLE_N
HFD2_k127_2262363_5	693661.Arcve_0129	5.511e-32	138.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2466R@183980|Archaeoglobi	183980|Archaeoglobi	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_2262363_0	1254432.SCE1572_47425	2.34e-124	409.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_2262363_2	706587.Desti_0005	1.795e-69	242.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MRXV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
HFD2_k127_2262363_1	278963.ATWD01000002_gene323	1.928e-110	367.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria,2JKSQ@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
HFD2_k127_2262363_4	204669.Acid345_1193	3.307e-43	167.0	COG1381@1|root,COG1381@2|Bacteria,3Y4AX@57723|Acidobacteria,2JJ0T@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HFD2_k127_2268245_5	526227.Mesil_1708	2.927e-12	68.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_2268245_3	864051.BurJ1DRAFT_2032	4.831e-97	334.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VMBM@28216|Betaproteobacteria,1KPHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953,ko:K18382	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703	RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_2268245_4	234267.Acid_2025	9.812e-95	325.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria	57723|Acidobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD2_k127_2268245_2	204669.Acid345_1560	1.065e-97	323.0	COG0740@1|root,COG0740@2|Bacteria,3Y2SY@57723|Acidobacteria,2JHPB@204432|Acidobacteriia	204432|Acidobacteriia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_2268245_1	204669.Acid345_1559	1.64e-200	632.0	COG1219@1|root,COG1219@2|Bacteria,3Y3MR@57723|Acidobacteria,2JHY7@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD2_k127_2268245_0	234267.Acid_2027	1.03e-241	754.0	COG0466@1|root,COG0466@2|Bacteria,3Y3DI@57723|Acidobacteria	57723|Acidobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD2_k127_2274258_2	1267535.KB906767_gene3058	9.466e-67	233.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria,2JHUJ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD2_k127_2274258_4	926560.KE387023_gene2058	1.921e-42	161.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_2274258_5	234267.Acid_2570	5.598e-34	139.0	COG0806@1|root,COG0806@2|Bacteria	2|Bacteria	J	ribosome binding	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HFD2_k127_2274258_6	234267.Acid_2571	4.075e-27	116.0	COG1837@1|root,COG1837@2|Bacteria,3Y5N5@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HFD2_k127_2274258_8	562970.Btus_1452	4.315e-23	101.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,27A1C@186823|Alicyclobacillaceae	91061|Bacilli	J	Ribosomal protein S16	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD2_k127_2274258_0	234267.Acid_2573	1.29e-165	531.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HFD2_k127_2274258_3	204669.Acid345_0555	4.097e-55	207.0	COG0628@1|root,COG0628@2|Bacteria,3Y4N5@57723|Acidobacteria,2JN2G@204432|Acidobacteriia	204432|Acidobacteriia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_2274258_7	309807.SRU_2769	2.639e-23	109.0	COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1FK4T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	PA26 p53-induced protein (sestrin)	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_2274258_1	886293.Sinac_3509	1.209e-97	342.0	COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
HFD2_k127_2315411_1	379066.GAU_2322	6.72e-80	268.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HFD2_k127_2315411_0	204669.Acid345_0002	1.343e-122	407.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria,2JI4X@204432|Acidobacteriia	204432|Acidobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD2_k127_2315411_2	639030.JHVA01000001_gene2200	3.57e-54	207.0	COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria,2JIQH@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_2316040_4	234267.Acid_5926	1.858e-28	123.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD2_k127_2316040_3	289376.THEYE_A0136	1.587e-45	169.0	COG0432@1|root,COG0432@2|Bacteria,3J1CB@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD2_k127_2316040_0	234267.Acid_1436	2.034e-138	447.0	COG3684@1|root,COG3981@1|root,COG3684@2|Bacteria,COG3981@2|Bacteria,3Y33H@57723|Acidobacteria	57723|Acidobacteria	G	deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_2316040_1	204669.Acid345_2181	1.807e-108	377.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria,2JKER@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
HFD2_k127_2316040_2	204669.Acid345_0913	5.1e-64	241.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria,2JP4V@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2316040_5	479434.Sthe_0488	3.996e-27	114.0	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi,27Y9D@189775|Thermomicrobia	200795|Chloroflexi	H	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	3.5.4.22	ko:K21062	ko00330,map00330	-	R02280	RC00679	ko00000,ko00001,ko01000	-	-	-	DHDPS
HFD2_k127_2338363_0	1499967.BAYZ01000135_gene84	3.89e-75	260.0	COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE_1	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HFD2_k127_2338363_2	1499967.BAYZ01000135_gene83	8.41e-25	107.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HFD2_k127_2338363_3	1265505.ATUG01000001_gene3110	3.994e-18	92.0	COG2172@1|root,COG2172@2|Bacteria,1Q2UT@1224|Proteobacteria,42V6B@68525|delta/epsilon subdivisions,2WRJ9@28221|Deltaproteobacteria,2MKWV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	anti-sigma regulatory factor	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD2_k127_2338363_1	234267.Acid_6483	2.963e-68	246.0	COG1538@1|root,COG1538@2|Bacteria,3Y7Q2@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_2339119_2	234267.Acid_0954	2.596e-28	124.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_2339119_0	1340493.JNIF01000003_gene4176	2.583e-104	346.0	COG0330@1|root,COG0330@2|Bacteria,3Y7B6@57723|Acidobacteria	57723|Acidobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_2339119_1	309799.DICTH_0379	1.99e-36	146.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Cu_amine_oxidN1,DLH,DUF3887,Hydrolase_4,Peptidase_S9
HFD2_k127_2346517_1	565033.GACE_0101	5.239e-72	254.0	COG0437@1|root,arCOG01500@2157|Archaea,2XXPU@28890|Euryarchaeota,24691@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4,Fer4_11
HFD2_k127_2346517_0	1379698.RBG1_1C00001G0295	3.681e-81	278.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	ko:K04013,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
HFD2_k127_2346517_2	653733.Selin_0487	7.646e-31	136.0	COG4885@1|root,COG4885@2|Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HFD2_k127_2355451_0	204669.Acid345_1143	9.57e-243	773.0	COG1874@1|root,COG1874@2|Bacteria,3Y6RS@57723|Acidobacteria,2JM2M@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2357815_9	1043205.AFYF01000026_gene411	5.498e-10	63.0	COG3011@1|root,COG3011@2|Bacteria,2IMHW@201174|Actinobacteria,4FHP0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HFD2_k127_2357815_8	285535.JOEY01000007_gene8551	1.292e-10	68.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HFD2_k127_2357815_7	1405296.Q499_0641	1.858e-11	68.0	COG0450@1|root,COG0450@2|Bacteria,2JFNN@204428|Chlamydiae	204428|Chlamydiae	O	Antioxidant, AhpC Tsa family	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HFD2_k127_2357815_1	682795.AciX8_3527	4.025e-123	407.0	COG0399@1|root,COG0399@2|Bacteria,3Y3PT@57723|Acidobacteria,2JHVI@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_2357815_5	264462.Bd2942	1.433e-30	133.0	COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,42WVD@68525|delta/epsilon subdivisions,2MTCG@213481|Bdellovibrionales,2WSWS@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD2_k127_2357815_3	234267.Acid_5592	2.119e-79	270.0	COG1845@1|root,COG1845@2|Bacteria,3Y5GJ@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_2357815_4	234267.Acid_5591	1.194e-46	177.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_2357815_0	234267.Acid_5590	1.475e-271	847.0	COG0843@1|root,COG0843@2|Bacteria,3Y2NS@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_2357815_2	234267.Acid_5589	1.261e-79	276.0	COG1622@1|root,COG1622@2|Bacteria,3Y4UA@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HFD2_k127_2383637_1	1340493.JNIF01000003_gene1957	2.953e-30	125.0	2DB97@1|root,32TX2@2|Bacteria,3Y59S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2383637_0	760568.Desku_1293	5.296e-57	213.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_2415076_2	1382359.JIAL01000001_gene184	5.633e-119	396.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JP2Q@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_2415076_3	234267.Acid_7679	7.187e-111	391.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_2415076_5	234267.Acid_4370	5.017e-40	154.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria	57723|Acidobacteria	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HFD2_k127_2415076_6	204669.Acid345_1208	9.411e-23	98.0	COG0828@1|root,COG0828@2|Bacteria,3Y5J9@57723|Acidobacteria,2JJWG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD2_k127_2415076_1	278963.ATWD01000001_gene2024	3.687e-164	525.0	COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria,2JIZF@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_2415076_0	1453500.AT05_05740	4.447e-176	561.0	COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,1HWRR@117743|Flavobacteriia	976|Bacteroidetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD2_k127_2415076_4	204669.Acid345_1073	8.313e-66	227.0	COG0696@1|root,COG0696@2|Bacteria,3Y2YH@57723|Acidobacteria,2JIZ0@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HFD2_k127_2428016_3	517418.Ctha_1581	6.979e-51	190.0	COG0612@1|root,COG0612@2|Bacteria,1FEWA@1090|Chlorobi	1090|Chlorobi	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_2428016_4	1231241.Mc24_06270	7.038e-13	72.0	COG1555@1|root,COG1555@2|Bacteria,2GD8U@200918|Thermotogae	200918|Thermotogae	L	TIGRFAM competence protein ComEA helix-hairpin-helix repeat	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HFD2_k127_2428016_0	204669.Acid345_3140	2.816e-150	484.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3Y339@57723|Acidobacteria,2JIM0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD2_k127_2428016_1	1379698.RBG1_1C00001G0364	4.207e-120	394.0	COG0306@1|root,COG0306@2|Bacteria,2NP4R@2323|unclassified Bacteria	2|Bacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD2_k127_2428016_2	204669.Acid345_3130	1.755e-56	205.0	COG1392@1|root,COG1392@2|Bacteria,3Y58U@57723|Acidobacteria,2JK4H@204432|Acidobacteriia	204432|Acidobacteriia	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD2_k127_2431844_2	234267.Acid_4431	1.615e-97	343.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_2431844_1	234267.Acid_4431	1.296e-195	646.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_2431844_0	1267533.KB906736_gene1246	1.448e-270	859.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_2431844_3	504472.Slin_1574	1.788e-64	237.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,4NK01@976|Bacteroidetes,47NT3@768503|Cytophagia	976|Bacteroidetes	G	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_2456533_1	204669.Acid345_2858	2.059e-221	712.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	2|Bacteria	I	Phosphate acyltransferases	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HFD2_k127_2456533_0	204669.Acid345_2658	1.995e-228	720.0	COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria,2JIXF@204432|Acidobacteriia	204432|Acidobacteriia	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_2456533_6	204669.Acid345_2659	3.082e-34	139.0	2BNC6@1|root,32GZV@2|Bacteria,3Y8TE@57723|Acidobacteria	57723|Acidobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD2_k127_2456533_4	1267535.KB906767_gene1295	5.087e-90	303.0	COG1692@1|root,COG1692@2|Bacteria,3Y3YJ@57723|Acidobacteria,2JIAY@204432|Acidobacteriia	204432|Acidobacteriia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HFD2_k127_2456533_2	234267.Acid_0825	1.899e-137	449.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2456533_3	234267.Acid_0826	1.232e-131	426.0	COG0803@1|root,COG0803@2|Bacteria,3Y97A@57723|Acidobacteria	57723|Acidobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
HFD2_k127_2456533_5	1379698.RBG1_1C00001G0109	3.14e-44	164.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HFD2_k127_2464909_0	234267.Acid_4184	0.0	1658.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria	57723|Acidobacteria	E	Vitamin B12 dependent methionine synthase activation	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HFD2_k127_2467461_4	269799.Gmet_0420	4.677e-38	147.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42VN1@68525|delta/epsilon subdivisions,2WRVD@28221|Deltaproteobacteria,43UW7@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HFD2_k127_2467461_7	671143.DAMO_0863	5.324e-15	78.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HFD2_k127_2467461_2	1173028.ANKO01000041_gene3162	5.396e-68	234.0	COG1839@1|root,COG1839@2|Bacteria,1G575@1117|Cyanobacteria,1HAQX@1150|Oscillatoriales	1117|Cyanobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HFD2_k127_2467461_8	622637.KE124774_gene2573	8.544e-05	47.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,36XJI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_2467461_3	1382359.JIAL01000001_gene461	2.764e-51	194.0	COG0590@1|root,COG0590@2|Bacteria,3Y4KB@57723|Acidobacteria,2JJC6@204432|Acidobacteriia	204432|Acidobacteriia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	DUF3175,MafB19-deam
HFD2_k127_2467461_5	487521.OCU_20150	7.086e-22	98.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,23511@1762|Mycobacteriaceae	201174|Actinobacteria	L	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_2467461_1	234267.Acid_5685	5.143e-72	245.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HFD2_k127_2467461_0	204669.Acid345_2696	5.69e-96	324.0	COG1085@1|root,COG1085@2|Bacteria,3Y41K@57723|Acidobacteria	2|Bacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
HFD2_k127_2467461_6	234267.Acid_3847	2.433e-17	91.0	COG1434@1|root,COG1434@2|Bacteria,3Y8M4@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD2_k127_2484239_1	1267533.KB906736_gene1017	9.254e-71	256.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria,2JI5M@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
HFD2_k127_2484239_0	240015.ACP_3488	6.287e-93	317.0	COG0763@1|root,COG0763@2|Bacteria,3Y34H@57723|Acidobacteria,2JID9@204432|Acidobacteriia	204432|Acidobacteriia	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HFD2_k127_2505399_2	204669.Acid345_1729	1.643e-32	129.0	COG1376@1|root,COG1376@2|Bacteria,3Y7TU@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD2_k127_2505399_0	204669.Acid345_1730	1.657e-147	480.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_2505399_1	204669.Acid345_1731	3.088e-41	168.0	2FAIU@1|root,342SV@2|Bacteria,3Y86W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2505399_3	266779.Meso_3635	1.787e-15	83.0	COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_2514695_0	941824.TCEL_02215	3.818e-56	198.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,36EFC@31979|Clostridiaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HFD2_k127_2516679_0	234267.Acid_2004	7.593e-213	691.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria	57723|Acidobacteria	M	PFAM glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD2_k127_2516679_1	1123388.AQWU01000041_gene454	0.0007833	48.0	COG0457@1|root,COG2010@1|root,COG0457@2|Bacteria,COG2010@2|Bacteria,1WJ9G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,TPR_11,TPR_16,TPR_19,TPR_8
HFD2_k127_2517607_2	671143.DAMO_0070	1.275e-82	285.0	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_2517607_0	671143.DAMO_0060	4.895e-134	443.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168,ko:K07479	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
HFD2_k127_2522959_3	204669.Acid345_1390	4.2e-37	141.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD2_k127_2522959_2	1396418.BATQ01000080_gene769	2.332e-40	154.0	2DN84@1|root,32W19@2|Bacteria,46W13@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2522959_1	204669.Acid345_1389	9.18e-111	377.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8
HFD2_k127_2522959_0	204669.Acid345_1388	1.262e-138	456.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	57723|Acidobacteria	T	response regulator, receiver	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_2536561_3	765420.OSCT_0710	4.549e-10	63.0	COG0491@1|root,COG0491@2|Bacteria,2G6KC@200795|Chloroflexi,376B0@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_2536561_2	1183438.GKIL_4241	2.897e-65	233.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria	1117|Cyanobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD2_k127_2536561_0	251221.35211733	1.243e-110	367.0	COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HFD2_k127_2536561_1	671143.DAMO_0488	6.995e-82	276.0	COG0166@1|root,COG0166@2|Bacteria,2NP2H@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the GPI family	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
HFD2_k127_2559554_4	1227457.C451_18643	8.661e-13	71.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,23SI7@183963|Halobacteria	183963|Halobacteria	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_2559554_0	682795.AciX8_0370	2.225e-96	323.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria,2JIMV@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HFD2_k127_2559554_1	204669.Acid345_0235	2.598e-90	304.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria,2JI06@204432|Acidobacteriia	204432|Acidobacteriia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HFD2_k127_2559554_3	240015.ACP_2637	7.179e-52	192.0	COG0764@1|root,COG0764@2|Bacteria,3Y7I3@57723|Acidobacteria,2JP4P@204432|Acidobacteriia	204432|Acidobacteriia	I	FabA-like domain	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HFD2_k127_2559554_2	1382359.JIAL01000001_gene1275	1.107e-52	200.0	COG0624@1|root,COG0624@2|Bacteria,3Y3J0@57723|Acidobacteria,2JI3Y@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_2561990_1	204669.Acid345_4495	7.089e-73	257.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD2_k127_2561990_0	204669.Acid345_1181	1.569e-85	289.0	COG2930@1|root,COG2930@2|Bacteria,3Y4GG@57723|Acidobacteria,2JKH3@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_2561990_2	1049564.TevJSym_ar00200	5.751e-40	153.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1J613@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane protein, hemolysin III homolog	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HFD2_k127_2588388_11	1047013.AQSP01000116_gene1111	1.437e-18	89.0	COG1028@1|root,COG1028@2|Bacteria,2NQXB@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_2588388_4	1047013.AQSP01000116_gene1110	6.814e-84	299.0	COG1004@1|root,COG1004@2|Bacteria,2NNYN@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_2588388_1	1047013.AQSP01000144_gene843	5.389e-138	457.0	COG2605@1|root,COG2605@2|Bacteria,2NP6Q@2323|unclassified Bacteria	2|Bacteria	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_2588388_3	926569.ANT_20250	6.449e-122	405.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi	200795|Chloroflexi	M	Short-chain dehydrogenase reductase SDR	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_2588388_5	1232410.KI421421_gene3366	2.501e-82	292.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,43UQ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD2_k127_2588388_8	446466.Cfla_3603	1.579e-55	202.0	COG0176@1|root,COG0176@2|Bacteria,2GSF7@201174|Actinobacteria	201174|Actinobacteria	H	Transaldolase	fsa	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_2588388_2	671143.DAMO_0194	3.184e-129	441.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HFD2_k127_2588388_7	1267535.KB906767_gene4038	2.654e-63	231.0	COG1596@1|root,COG1596@2|Bacteria,3Y7Z0@57723|Acidobacteria	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_2588388_9	172088.AUGA01000062_gene1400	7.396e-44	163.0	COG0251@1|root,COG0251@2|Bacteria,1PEAI@1224|Proteobacteria,2UFF9@28211|Alphaproteobacteria,3K0X0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_2588388_14	1341151.ASZU01000033_gene1638	0.000215	44.0	2EG8N@1|root,33A0G@2|Bacteria,1UPXM@1239|Firmicutes,4IVCT@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2588388_15	639030.JHVA01000001_gene2443	0.0007658	47.0	2E5J5@1|root,330AF@2|Bacteria,3Y5HZ@57723|Acidobacteria,2JJVY@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HFD2_k127_2588388_6	335543.Sfum_0066	6.697e-71	245.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2MQF0@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HFD2_k127_2588388_0	234267.Acid_7339	5.738e-207	653.0	COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria	57723|Acidobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HFD2_k127_2588388_10	234267.Acid_1064	5.26e-28	128.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria	57723|Acidobacteria	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2600941_7	240015.ACP_2014	9.032e-19	90.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria,2JIM3@204432|Acidobacteriia	204432|Acidobacteriia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD2_k127_2600941_4	713586.KB900536_gene805	2.76e-65	233.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales	135613|Chromatiales	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_2600941_1	383372.Rcas_2891	2.58e-92	315.0	COG3804@1|root,COG3804@2|Bacteria,2G7MJ@200795|Chloroflexi	200795|Chloroflexi	C	Dihydrodipicolinate reductase, N-terminus	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
HFD2_k127_2600941_6	1004149.AFOE01000050_gene2605	6.985e-28	116.0	COG2154@1|root,COG2154@2|Bacteria,4NS9U@976|Bacteroidetes,1I40R@117743|Flavobacteriia	976|Bacteroidetes	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD2_k127_2600941_2	1469613.JT55_16070	6.506e-69	253.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HFD2_k127_2600941_0	1121403.AUCV01000020_gene3107	1.461e-106	353.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,43DE0@68525|delta/epsilon subdivisions,2X8JX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2600941_5	1121403.AUCV01000020_gene3106	2.335e-48	186.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HFD2_k127_2600941_3	1121403.AUCV01000020_gene3105	5.278e-66	231.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42NE7@68525|delta/epsilon subdivisions,2WJ77@28221|Deltaproteobacteria,2MM3R@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_2612103_3	1167006.UWK_01410	4.301e-52	193.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MJHY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD2_k127_2612103_2	1122137.AQXF01000003_gene2088	2.211e-129	427.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_2612103_0	204669.Acid345_2533	0.0	1118.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_2612103_5	868595.Desca_1044	6.527e-36	147.0	COG2215@1|root,COG2215@2|Bacteria,1VA77@1239|Firmicutes	1239|Firmicutes	S	PFAM Nickel cobalt transporter, high-affinity	ureH	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
HFD2_k127_2612103_4	1041146.ATZB01000029_gene5428	3.168e-41	160.0	COG0500@1|root,COG2226@2|Bacteria,1RD2T@1224|Proteobacteria,2VBBK@28211|Alphaproteobacteria,4BJ74@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_2612103_1	204669.Acid345_4052	2.016e-302	939.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,3Y4RT@57723|Acidobacteria	57723|Acidobacteria	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
HFD2_k127_2642922_1	204669.Acid345_0809	1.131e-76	281.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HFD2_k127_2642922_3	525257.HMPREF0204_14544	2.165e-23	113.0	2EJYA@1|root,33DNX@2|Bacteria,4P21C@976|Bacteroidetes,1ICJV@117743|Flavobacteriia,3ZRJ3@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2642922_2	1267533.KB906733_gene3391	1.036e-31	131.0	COG0802@1|root,COG0802@2|Bacteria,3Y4WF@57723|Acidobacteria,2JMZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD2_k127_2642922_0	234267.Acid_2158	2.428e-124	416.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3Y3XN@57723|Acidobacteria	57723|Acidobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_2657891_3	237368.SCABRO_02008	4.605e-09	60.0	COG0852@1|root,COG0852@2|Bacteria,2IZSU@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_2657891_0	204669.Acid345_1315	5.326e-39	149.0	COG0838@1|root,COG0838@2|Bacteria,3Y5CV@57723|Acidobacteria,2JP4J@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD2_k127_2657891_1	1121920.AUAU01000025_gene2317	3.707e-15	84.0	2ET40@1|root,33KN7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2657891_2	1123503.KB908059_gene478	9.754e-15	76.0	COG2022@1|root,COG2022@2|Bacteria,1QYPA@1224|Proteobacteria,2TXU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
HFD2_k127_2673838_1	1041930.Mtc_1015	2.478e-49	196.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03042@2157|Archaea,2Y7M7@28890|Euryarchaeota,2NBM0@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
HFD2_k127_2673838_0	1267534.KB906754_gene2651	6.447e-144	469.0	COG0183@1|root,COG0183@2|Bacteria,3Y3SQ@57723|Acidobacteria,2JHU2@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_2680656_3	596154.Alide2_3698	1.205e-40	160.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_2680656_2	234267.Acid_2001	1.449e-41	156.0	COG2315@1|root,COG2315@2|Bacteria	2|Bacteria	V	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD2_k127_2680656_1	204669.Acid345_3196	2.867e-79	271.0	COG0428@1|root,COG0428@2|Bacteria,3Y4A7@57723|Acidobacteria,2JJ1K@204432|Acidobacteriia	204432|Acidobacteriia	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
HFD2_k127_2680656_0	204669.Acid345_3198	1.726e-116	385.0	COG0012@1|root,COG0012@2|Bacteria,3Y3D9@57723|Acidobacteria,2JIPE@204432|Acidobacteriia	204432|Acidobacteriia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD2_k127_2680656_4	1232410.KI421421_gene3477	0.0006651	43.0	2CHSG@1|root,316CZ@2|Bacteria,1PXCU@1224|Proteobacteria,4308W@68525|delta/epsilon subdivisions,2WVAX@28221|Deltaproteobacteria,43V1W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
HFD2_k127_2681637_12	1348657.M622_05350	1.773e-13	73.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VQN1@28216|Betaproteobacteria,2KYSK@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_2681637_15	1173028.ANKO01000031_gene3926	2.14e-05	53.0	COG0463@1|root,COG0463@2|Bacteria,1G00A@1117|Cyanobacteria,1H6XK@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2681637_3	1211114.ALIP01000012_gene1397	2.615e-34	139.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria,1XD5Y@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2681637_7	59374.Fisuc_0695	1.698e-22	113.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HFD2_k127_2681637_6	1536772.R70723_04650	7.825e-24	118.0	COG0438@1|root,COG0438@2|Bacteria,1VEAG@1239|Firmicutes,4HN0E@91061|Bacilli,26TW2@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_2681637_14	383372.Rcas_4268	3.099e-07	63.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi,375HE@32061|Chloroflexia	32061|Chloroflexia	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD2_k127_2681637_11	575540.Isop_0468	1.768e-13	80.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,2J55B@203682|Planctomycetes	203682|Planctomycetes	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_2681637_5	1289387.AUKW01000021_gene3232	1.067e-24	120.0	COG0728@1|root,COG0728@2|Bacteria,2GKBV@201174|Actinobacteria	201174|Actinobacteria	K	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_2681637_4	323261.Noc_1503	1.103e-33	146.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,1RQWW@1236|Gammaproteobacteria,1WZJ1@135613|Chromatiales	135613|Chromatiales	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD2_k127_2681637_8	335543.Sfum_3322	1.208e-17	96.0	COG0457@1|root,COG0457@2|Bacteria,1NJFX@1224|Proteobacteria,42ZX8@68525|delta/epsilon subdivisions,2WVHJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2681637_13	289377.HL41_03700	5.604e-10	68.0	COG0484@1|root,COG0484@2|Bacteria,2GHWT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HFD2_k127_2681637_1	204669.Acid345_2219	2.903e-151	511.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y9GC@57723|Acidobacteria,2JKTW@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_2681637_9	886293.Sinac_0326	1.243e-16	91.0	COG0457@1|root,COG0457@2|Bacteria,2IZWD@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HFD2_k127_2681637_2	1198114.AciX9_2175	5.632e-63	224.0	COG0229@1|root,COG0229@2|Bacteria,3Y6UH@57723|Acidobacteria,2JMMX@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Methionine sulfoxide reductase B	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_2681637_0	575540.Isop_3282	0.0	1348.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2IX33@203682|Planctomycetes	203682|Planctomycetes	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HFD2_k127_2703711_3	323261.Noc_1254	1.415e-37	143.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_2703711_2	1173024.KI912149_gene5496	1.45e-109	385.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_9
HFD2_k127_2703711_0	1242864.D187_005861	1.824e-198	632.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_2703711_4	1303518.CCALI_01619	1.084e-11	76.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Hydrolase_4
HFD2_k127_2703711_1	234267.Acid_5676	1.972e-116	401.0	COG0515@1|root,COG1262@1|root,COG1506@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	1.14.99.50,2.7.11.1	ko:K01990,ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	M00254	R11013	RC03323,RC03324	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1	-	-	FGE-sulfatase,Peptidase_S15,Pkinase
HFD2_k127_2706645_0	1249627.D779_4189	3.115e-209	687.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales	135613|Chromatiales	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
HFD2_k127_2706645_4	204669.Acid345_2941	1.51e-53	199.0	COG0589@1|root,COG0589@2|Bacteria,3Y5Y7@57723|Acidobacteria,2JK6C@204432|Acidobacteriia	204432|Acidobacteriia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_2706645_1	204669.Acid345_4378	4.865e-97	335.0	28K04@1|root,2Z9Q3@2|Bacteria,3Y344@57723|Acidobacteria,2JHZP@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2706645_7	1197906.CAJQ02000011_gene1039	9.912e-24	107.0	COG2849@1|root,COG2849@2|Bacteria,1NFB6@1224|Proteobacteria,2UH63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2706645_2	1267534.KB906754_gene2794	2.841e-89	299.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_2706645_8	240015.ACP_3296	1.07e-22	104.0	COG2510@1|root,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
HFD2_k127_2706645_9	338966.Ppro_2827	6.429e-13	78.0	COG2510@1|root,COG2510@2|Bacteria,1NDZV@1224|Proteobacteria,42V6K@68525|delta/epsilon subdivisions,2WRTX@28221|Deltaproteobacteria,43UXY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_2706645_3	240015.ACP_1042	1.936e-80	282.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	hpnI	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HFD2_k127_2706645_5	682795.AciX8_0983	1.669e-47	180.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria,2JJ5K@204432|Acidobacteriia	204432|Acidobacteriia	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD2_k127_2706645_6	1005048.CFU_2789	1.24e-35	136.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VMGR@28216|Betaproteobacteria,4751C@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_2721683_1	1267535.KB906767_gene109	1.244e-35	143.0	COG0531@1|root,COG0531@2|Bacteria,3Y2RG@57723|Acidobacteria,2JHMH@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_272406_2	204669.Acid345_4041	3.709e-67	231.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria,2JJC7@204432|Acidobacteriia	204432|Acidobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD2_k127_272406_3	234267.Acid_0376	3.2e-66	238.0	COG0454@1|root,COG0456@2|Bacteria,3Y3VJ@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_272406_5	1408254.T458_22405	1.243e-12	78.0	COG1073@1|root,COG1073@2|Bacteria,1UZWJ@1239|Firmicutes,4HE5X@91061|Bacilli,26RHK@186822|Paenibacillaceae	91061|Bacilli	S	Alpha beta	yfhR1	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_272406_1	204669.Acid345_4212	1.215e-76	277.0	COG1807@1|root,COG1807@2|Bacteria,3Y2K3@57723|Acidobacteria,2JHZC@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_272406_0	204669.Acid345_2346	7.493e-99	331.0	COG1560@1|root,COG1560@2|Bacteria,3Y2RW@57723|Acidobacteria,2JIMS@204432|Acidobacteriia	204432|Acidobacteriia	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD2_k127_272406_4	234267.Acid_2848	6.89e-61	221.0	COG1044@1|root,COG1044@2|Bacteria,3Y6ZT@57723|Acidobacteria	57723|Acidobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD2_k127_2728722_1	1122137.AQXF01000001_gene3064	2.256e-66	235.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2TSXN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD2_k127_2728722_2	357808.RoseRS_0654	7.075e-27	114.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2728722_3	118168.MC7420_1664	1.824e-20	93.0	COG2442@1|root,COG2442@2|Bacteria,1GA44@1117|Cyanobacteria,1HC3P@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD2_k127_2728722_4	378806.STAUR_1028	2.285e-17	82.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_2728722_0	448385.sce5882	2.049e-87	293.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_2734959_0	1267534.KB906754_gene2687	1.74e-97	327.0	COG0308@1|root,COG0308@2|Bacteria,3Y71N@57723|Acidobacteria,2JMDX@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_2734959_5	1288963.ADIS_2389	1.001e-16	82.0	COG2827@1|root,COG2827@2|Bacteria,4NWTG@976|Bacteroidetes	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
HFD2_k127_2734959_8	1122998.AUHZ01000002_gene2365	6.82e-05	47.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_2734959_3	1144275.COCOR_01398	7.948e-54	193.0	COG0346@1|root,COG0346@2|Bacteria,1RIAM@1224|Proteobacteria,43827@68525|delta/epsilon subdivisions,2X3CD@28221|Deltaproteobacteria,2YVE1@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_2734959_2	682795.AciX8_0311	1.08e-54	200.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria,2JJ89@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_2734959_4	1382359.JIAL01000001_gene2831	9.891e-19	98.0	COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria,2JJ7U@204432|Acidobacteriia	204432|Acidobacteriia	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_2734959_1	234267.Acid_1806	7.564e-63	237.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_2734959_7	1156937.MFUM_130010	4.651e-08	57.0	COG0571@1|root,COG0571@2|Bacteria,46T3X@74201|Verrucomicrobia,37H55@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD2_k127_2763351_2	105420.BBPO01000001_gene269	6.71e-05	52.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,2NEI0@228398|Streptacidiphilus	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2763351_1	945713.IALB_0545	3.566e-72	254.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_2763351_0	760192.Halhy_3894	2.172e-77	264.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1IVI6@117747|Sphingobacteriia	976|Bacteroidetes	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HFD2_k127_2763548_3	1521187.JPIM01000116_gene3544	1.066e-98	332.0	COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,37550@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_2763548_0	204669.Acid345_0953	1.772e-200	634.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_2763548_2	204669.Acid345_0952	1.403e-155	499.0	COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
HFD2_k127_2763548_6	204669.Acid345_0951	3.596e-31	124.0	COG1146@1|root,COG1146@2|Bacteria,3Y8V9@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD2_k127_2763548_1	234267.Acid_5425	6.883e-178	569.0	COG0427@1|root,COG0427@2|Bacteria,3Y3BI@57723|Acidobacteria	57723|Acidobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HFD2_k127_2763548_5	204669.Acid345_0949	1.745e-39	153.0	2EBAA@1|root,335AW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
HFD2_k127_2763548_4	401526.TcarDRAFT_1041	5.577e-55	196.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H278@909932|Negativicutes	909932|Negativicutes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_2779546_0	745411.B3C1_04575	3.979e-140	463.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2939 Carboxypeptidase C (cathepsin A)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HFD2_k127_2779546_8	204669.Acid345_1452	5.65e-22	102.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2779546_7	452637.Oter_4180	1.643e-44	168.0	COG5478@1|root,COG5478@2|Bacteria,46SXC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HFD2_k127_2779546_10	247490.KSU1_C0617	1.053e-15	79.0	28SF2@1|root,2ZERN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2779546_9	999419.HMPREF1077_02559	4.981e-19	90.0	COG2261@1|root,COG2261@2|Bacteria,4NUXX@976|Bacteroidetes,2FUM7@200643|Bacteroidia	976|Bacteroidetes	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_2779546_5	700598.Niako_2915	3.449e-62	225.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	MA20_39355	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_2779546_6	748247.AZKH_0156	3.429e-58	206.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VRX6@28216|Betaproteobacteria,2KWX0@206389|Rhodocyclales	206389|Rhodocyclales	S	Glyoxalase-like domain	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_2779546_1	1121920.AUAU01000013_gene1721	4.445e-123	407.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_2779546_2	204669.Acid345_0827	1.81e-103	342.0	COG0600@1|root,COG0600@2|Bacteria,3Y5KR@57723|Acidobacteria,2JNDD@204432|Acidobacteriia	204432|Acidobacteriia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_2779546_3	635013.TherJR_2252	3.314e-82	286.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,26175@186807|Peptococcaceae	186801|Clostridia	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_2779546_4	204669.Acid345_0825	4.027e-63	220.0	COG0715@1|root,COG0715@2|Bacteria,3Y5UN@57723|Acidobacteria,2JNY2@204432|Acidobacteriia	204432|Acidobacteriia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD2_k127_278280_1	234267.Acid_4393	1.532e-08	59.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_278280_0	1337936.IJ00_01670	2.017e-125	417.0	COG1680@1|root,COG1680@2|Bacteria,1G5Z2@1117|Cyanobacteria,1HIVF@1161|Nostocales	1117|Cyanobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_2793175_3	682795.AciX8_4155	7.135e-40	153.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD2_k127_2793175_1	709991.Odosp_3390	3.79e-213	691.0	COG3534@1|root,COG3534@2|Bacteria,4NHR5@976|Bacteroidetes,2G2XU@200643|Bacteroidia,231K5@171551|Porphyromonadaceae	976|Bacteroidetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HFD2_k127_2793175_0	234267.Acid_4917	0.0	1067.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3EW@57723|Acidobacteria	57723|Acidobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HFD2_k127_2793175_2	671143.DAMO_0485	2.135e-51	189.0	COG0363@1|root,COG0363@2|Bacteria,2NPBM@2323|unclassified Bacteria	2|Bacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD2_k127_2804369_2	450851.PHZ_c2929	2.201e-123	405.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2KJSY@204458|Caulobacterales	204458|Caulobacterales	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HFD2_k127_2804369_1	1131451.O1K_16551	5.517e-190	612.0	COG3669@1|root,COG3669@2|Bacteria,1R6V7@1224|Proteobacteria,1RWFD@1236|Gammaproteobacteria,1X3J1@135614|Xanthomonadales	135614|Xanthomonadales	G	alpha-l-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
HFD2_k127_2804369_0	1267533.KB906737_gene1791	4.76e-213	672.0	COG1070@1|root,COG1070@2|Bacteria,3Y2V6@57723|Acidobacteria,2JJ35@204432|Acidobacteriia	204432|Acidobacteriia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_2804369_3	204669.Acid345_0809	1.672e-75	267.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HFD2_k127_2859518_0	1379270.AUXF01000005_gene474	2.704e-134	455.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSZA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_2859518_7	1298598.JCM21714_1045	8.988e-24	106.0	COG3339@1|root,COG3339@2|Bacteria,1VC4G@1239|Firmicutes,4IRHA@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HFD2_k127_2859518_3	479434.Sthe_2593	1.064e-61	229.0	COG1834@1|root,COG1834@2|Bacteria,2G7QT@200795|Chloroflexi,27YZU@189775|Thermomicrobia	189775|Thermomicrobia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HFD2_k127_2859518_2	1347392.CCEZ01000023_gene794	3.91e-72	260.0	COG0833@1|root,COG0833@2|Bacteria,1UHPU@1239|Firmicutes,25E64@186801|Clostridia	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_2859518_8	1298863.AUEP01000010_gene4549	1.723e-08	58.0	COG2827@1|root,COG2827@2|Bacteria,2GSD8@201174|Actinobacteria	201174|Actinobacteria	L	Excinuclease abc c subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HFD2_k127_2859518_9	1125863.JAFN01000001_gene2333	2.315e-05	47.0	COG2161@1|root,COG2161@2|Bacteria,1R2Q0@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_2859518_6	1267535.KB906767_gene457	2.696e-26	123.0	COG0457@1|root,COG0457@2|Bacteria,3Y7U6@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2859518_10	1049564.TevJSym_ax00270	7.47e-05	47.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HFD2_k127_2859518_4	240015.ACP_3396	5.032e-35	138.0	COG1917@1|root,COG1917@2|Bacteria,3Y596@57723|Acidobacteria,2JJRV@204432|Acidobacteriia	204432|Acidobacteriia	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_2859518_1	234267.Acid_7473	9.819e-91	307.0	COG1028@1|root,COG1028@2|Bacteria,3Y4CZ@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_2859518_5	1173021.ALWA01000025_gene2528	3.193e-31	135.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1G03V@1117|Cyanobacteria	1117|Cyanobacteria	CE	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,HEAT_2,Peptidase_M1
HFD2_k127_2860980_0	266117.Rxyl_0746	6.081e-108	354.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CPXX@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_2860980_3	278963.ATWD01000001_gene4324	2.659e-17	88.0	2CBQR@1|root,32RTV@2|Bacteria,3Y57Z@57723|Acidobacteria,2JJRD@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2860980_2	1120973.AQXL01000118_gene513	2.092e-23	107.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HHF8@91061|Bacilli,27A1Q@186823|Alicyclobacillaceae	91061|Bacilli	P	Ferric uptake regulator family	perR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_2860980_5	1123393.KB891316_gene1397	2.29e-10	68.0	COG0526@1|root,COG0526@2|Bacteria,1PIAQ@1224|Proteobacteria,2W6Y5@28216|Betaproteobacteria,1KTDF@119069|Hydrogenophilales	119069|Hydrogenophilales	CO	Glutaredoxin-like domain (DUF836)	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
HFD2_k127_2860980_1	234267.Acid_2155	5.82e-32	131.0	2E65M@1|root,330UB@2|Bacteria	2|Bacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_2860980_4	756272.Plabr_0475	6.945e-12	70.0	COG0745@1|root,COG0745@2|Bacteria,2J1NZ@203682|Planctomycetes	203682|Planctomycetes	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2862141_1	1267535.KB906767_gene5095	3.233e-70	243.0	COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria,2JIKF@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD2_k127_2862141_0	1267535.KB906767_gene5096	1.942e-147	470.0	COG0388@1|root,COG0388@2|Bacteria,3Y2T9@57723|Acidobacteria,2JI2H@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_2862141_2	204669.Acid345_1942	6.699e-54	195.0	COG1899@1|root,COG1899@2|Bacteria,3Y5EW@57723|Acidobacteria,2JJNA@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HFD2_k127_2928142_2	330214.NIDE2777	1.209e-40	158.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HFD2_k127_2928142_1	1298920.KI911353_gene4480	6.254e-48	184.0	COG0662@1|root,COG0662@2|Bacteria,1V7K2@1239|Firmicutes,24JIQ@186801|Clostridia	186801|Clostridia	G	PFAM Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_2928142_0	639030.JHVA01000001_gene3449	1.634e-66	234.0	COG1109@1|root,COG1109@2|Bacteria,3Y2F7@57723|Acidobacteria,2JHIV@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_2940161_0	1267535.KB906767_gene4789	8.953e-81	274.0	COG1064@1|root,COG1064@2|Bacteria,3Y34K@57723|Acidobacteria,2JIU5@204432|Acidobacteriia	204432|Acidobacteriia	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD2_k127_2940161_1	204669.Acid345_1052	7.43e-65	233.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HFD2_k127_2941297_0	760192.Halhy_0173	1.19e-233	740.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1IWK9@117747|Sphingobacteriia	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
HFD2_k127_2946612_0	497964.CfE428DRAFT_1795	6.029e-21	101.0	COG0196@1|root,COG0196@2|Bacteria,46SZ6@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HFD2_k127_2956938_6	292563.Cyast_0296	2.47e-38	147.0	COG0399@1|root,COG0399@2|Bacteria,1G88E@1117|Cyanobacteria	1117|Cyanobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD2_k127_2956938_1	1444711.CCJF01000005_gene196	2.868e-200	657.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2JFD0@204428|Chlamydiae	204428|Chlamydiae	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_2956938_4	1267535.KB906767_gene659	5.696e-78	269.0	COG1273@1|root,COG1273@2|Bacteria,3Y4E7@57723|Acidobacteria,2JNYV@204432|Acidobacteriia	204432|Acidobacteriia	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
HFD2_k127_2956938_3	1192034.CAP_4725	4.449e-80	299.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
HFD2_k127_2956938_5	1463887.KL589957_gene821	2.223e-42	162.0	COG3467@1|root,COG3467@2|Bacteria,2I5VH@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_2956938_0	1267533.KB906736_gene1246	4.49e-278	882.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_2956938_2	240015.ACP_3479	7.306e-168	554.0	COG2091@1|root,COG2091@2|Bacteria,3Y46J@57723|Acidobacteria,2JHWP@204432|Acidobacteriia	204432|Acidobacteriia	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2956938_7	1267535.KB906767_gene445	1.309e-11	74.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD2_k127_2964594_1	240015.ACP_1518	3.176e-22	102.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria,2JIUC@204432|Acidobacteriia	204432|Acidobacteriia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HFD2_k127_2964594_0	234267.Acid_7037	4.204e-50	189.0	COG0468@1|root,COG0468@2|Bacteria,3Y4QB@57723|Acidobacteria	57723|Acidobacteria	L	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	RecA
HFD2_k127_2964594_2	483219.LILAB_17930	1.274e-09	60.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YXZG@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_2992477_1	1123368.AUIS01000026_gene1459	1.308e-76	259.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,2NCT5@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD2_k127_2992477_0	234267.Acid_0469	5.53e-231	718.0	COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria	57723|Acidobacteria	E	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HFD2_k127_2998774_4	671143.DAMO_3155	2.183e-86	304.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HFD2_k127_2998774_3	871968.DESME_13850	4.587e-89	303.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,261I1@186807|Peptococcaceae	186801|Clostridia	P	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_2998774_2	1168034.FH5T_00680	5.262e-123	408.0	COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,2FM6F@200643|Bacteroidia	976|Bacteroidetes	V	ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_2998774_10	1196083.SALWKB12_0306	1.795e-40	154.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KQZB@206351|Neisseriales	206351|Neisseriales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD2_k127_2998774_8	204669.Acid345_0590	6.325e-50	190.0	COG1729@1|root,COG1729@2|Bacteria,3Y3H6@57723|Acidobacteria,2JIES@204432|Acidobacteriia	204432|Acidobacteriia	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HFD2_k127_2998774_6	234267.Acid_0513	9.042e-68	238.0	COG2885@1|root,COG2885@2|Bacteria,3Y3ZY@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD2_k127_2998774_1	204669.Acid345_0592	6.905e-139	454.0	COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria,2JIV3@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD2_k127_2998774_11	204669.Acid345_0593	6.582e-34	141.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria,2JJSC@204432|Acidobacteriia	204432|Acidobacteriia	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2
HFD2_k127_2998774_9	204669.Acid345_0594	3.179e-49	179.0	COG0848@1|root,COG0848@2|Bacteria,3Y4QV@57723|Acidobacteria,2JJ9P@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HFD2_k127_2998774_7	204669.Acid345_0595	3.827e-53	195.0	COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria,2JIN7@204432|Acidobacteriia	204432|Acidobacteriia	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HFD2_k127_2998774_0	234267.Acid_6704	1.502e-185	591.0	COG0621@1|root,COG0621@2|Bacteria,3Y2GT@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_2998774_5	234267.Acid_6705	2.089e-76	259.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria	57723|Acidobacteria	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HFD2_k127_2998774_12	1123261.AXDW01000023_gene3575	1.379e-16	88.0	COG1917@1|root,COG1917@2|Bacteria,1MZFB@1224|Proteobacteria,1SQCZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_3010127_0	1267535.KB906767_gene1458	3.033e-212	674.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HFD2_k127_3010127_1	698757.Pogu_0163	1.688e-83	283.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD2_k127_3010127_2	1267535.KB906767_gene5356	5.433e-69	242.0	COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD2_k127_3010127_3	204669.Acid345_2031	2.56e-25	107.0	COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD2_k127_3016319_3	1444711.CCJF01000005_gene546	1.172e-71	268.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
HFD2_k127_3016319_12	326424.FRAAL6628	1.4e-11	78.0	COG1361@1|root,COG3468@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3468@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria	201174|Actinobacteria	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,fn3
HFD2_k127_3016319_2	1267534.KB906754_gene3368	1.652e-73	249.0	COG5649@1|root,COG5649@2|Bacteria,3Y4QH@57723|Acidobacteria,2JMZM@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_3016319_8	204669.Acid345_4174	2.974e-24	104.0	COG2952@1|root,COG2952@2|Bacteria,3Y57Q@57723|Acidobacteria,2JJRA@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
HFD2_k127_3016319_9	682795.AciX8_2600	3.748e-24	104.0	COG2952@1|root,COG2952@2|Bacteria,3Y55F@57723|Acidobacteria,2JJNJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
HFD2_k127_3016319_0	1267535.KB906767_gene5038	1.133e-110	369.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria,2JI98@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_3016319_1	234267.Acid_4805	3.582e-75	260.0	COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria	57723|Acidobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HFD2_k127_3016319_4	234267.Acid_1849	1.294e-59	216.0	COG1028@1|root,COG1028@2|Bacteria,3Y6JP@57723|Acidobacteria	57723|Acidobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_3016319_6	926566.Terro_2778	8.052e-27	116.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD2_k127_3016319_7	234267.Acid_2812	8.37e-27	114.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria	57723|Acidobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_3016319_5	1009370.ALO_21174	5.978e-29	124.0	COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,4H4RE@909932|Negativicutes	909932|Negativicutes	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_3016319_11	234267.Acid_2901	3.094e-12	68.0	COG1975@1|root,COG1975@2|Bacteria,3Y54Y@57723|Acidobacteria	57723|Acidobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD2_k127_3020258_1	204669.Acid345_1734	5.499e-35	136.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_3020258_0	234267.Acid_7874	6.769e-190	612.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_3039882_2	240015.ACP_2080	8.161e-131	426.0	COG2255@1|root,COG2255@2|Bacteria,3Y2RP@57723|Acidobacteria,2JIMW@204432|Acidobacteriia	204432|Acidobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HFD2_k127_3039882_8	204669.Acid345_1563	5.144e-24	104.0	2ESJ3@1|root,33K3T@2|Bacteria,3Y8Y6@57723|Acidobacteria,2JNTF@204432|Acidobacteriia	204432|Acidobacteriia	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD2_k127_3039882_4	671143.DAMO_2403	2.194e-51	188.0	COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HFD2_k127_3039882_1	1120949.KB903297_gene5433	6.628e-131	428.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4DB1Y@85008|Micromonosporales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_3039882_6	234267.Acid_0324	4.641e-39	147.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD2_k127_3039882_9	234267.Acid_0323	1.062e-23	103.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD2_k127_3039882_7	234267.Acid_0322	3.844e-34	133.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HFD2_k127_3039882_5	234267.Acid_0321	1.71e-42	158.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
HFD2_k127_3039882_3	234267.Acid_0320	3.229e-83	284.0	COG0235@1|root,COG0235@2|Bacteria,3Y4E0@57723|Acidobacteria	57723|Acidobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD2_k127_3039882_0	240015.ACP_2883	2.814e-189	600.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_3082486_1	234267.Acid_3675	2.826e-97	332.0	COG1921@1|root,COG1921@2|Bacteria,3Y39V@57723|Acidobacteria	57723|Acidobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HFD2_k127_3082486_2	204669.Acid345_0269	2.443e-32	134.0	2ENGH@1|root,33G40@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3082486_0	926566.Terro_3422	1.64e-184	590.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD2_k127_3086887_5	745014.OMB55_00021020	1.503e-09	59.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_3086887_3	204669.Acid345_0036	9.04e-37	145.0	COG4319@1|root,COG4319@2|Bacteria,3Y5BE@57723|Acidobacteria,2JJS4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HFD2_k127_3086887_4	1121957.ATVL01000012_gene650	8.179e-31	134.0	COG5266@1|root,COG5266@2|Bacteria,4NQ8X@976|Bacteroidetes,47QXS@768503|Cytophagia	976|Bacteroidetes	P	Domain of unknown function (DUF4198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
HFD2_k127_3086887_1	240015.ACP_3048	8.359e-138	446.0	COG0332@1|root,COG0332@2|Bacteria,3Y2Z5@57723|Acidobacteria,2JIAW@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD2_k127_3086887_0	1198452.Jab_2c09150	4.147e-180	590.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,2WCWE@28216|Betaproteobacteria,478B5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3086887_6	123214.PERMA_1951	3.987e-07	63.0	COG0457@1|root,COG0457@2|Bacteria	123214.PERMA_1951|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3086887_2	234267.Acid_7272	5.693e-75	261.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria	57723|Acidobacteria	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_3089821_1	1267533.KB906736_gene1179	6.683e-48	187.0	COG1408@1|root,COG1408@2|Bacteria,3Y4DF@57723|Acidobacteria,2JJ4Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_3089821_0	886293.Sinac_1427	1.081e-127	417.0	COG0213@1|root,COG0213@2|Bacteria,2IY57@203682|Planctomycetes	203682|Planctomycetes	F	PFAM Glycosyl transferase, family	-	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD2_k127_3105946_0	85643.Tmz1t_0618	8.484e-63	222.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2WGTA@28216|Betaproteobacteria,2KZWK@206389|Rhodocyclales	206389|Rhodocyclales	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3108794_1	1304885.AUEY01000022_gene3393	6.807e-30	126.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_3108794_0	1415780.JPOG01000001_gene961	3.413e-88	305.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria,1X78Y@135614|Xanthomonadales	135614|Xanthomonadales	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_3115840_13	1211114.ALIP01000119_gene439	2.288e-43	165.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RPSX@1236|Gammaproteobacteria,1XCHP@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_3115840_11	1125863.JAFN01000001_gene2898	1.008e-56	201.0	COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HFD2_k127_3115840_8	1437425.CSEC_2446	2.944e-66	237.0	COG0596@1|root,COG0596@2|Bacteria,2JGMW@204428|Chlamydiae	204428|Chlamydiae	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3115840_0	1267533.KB906739_gene2638	2.4e-248	778.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria,2JHJN@204432|Acidobacteriia	204432|Acidobacteriia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_3115840_4	1340493.JNIF01000003_gene4130	1.345e-112	388.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_3115840_12	138119.DSY2855	6.572e-55	202.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD2_k127_3115840_7	234267.Acid_4994	3.635e-70	245.0	COG0101@1|root,COG0101@2|Bacteria,3Y2MS@57723|Acidobacteria	57723|Acidobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD2_k127_3115840_16	1267535.KB906767_gene3135	7.994e-18	94.0	COG2304@1|root,COG2304@2|Bacteria,3Y8A4@57723|Acidobacteria	57723|Acidobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HFD2_k127_3115840_2	204669.Acid345_1443	8.146e-157	511.0	COG1012@1|root,COG1012@2|Bacteria,3Y6J2@57723|Acidobacteria,2JMD6@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
HFD2_k127_3115840_17	234267.Acid_7046	3.831e-17	84.0	2FF7H@1|root,3475G@2|Bacteria,3Y8K8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3115840_3	1379698.RBG1_1C00001G0513	9.166e-135	441.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_3115840_5	204669.Acid345_1442	6.778e-97	332.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria,2JINN@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase, M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_3115840_1	1382359.JIAL01000001_gene2047	1.897e-160	524.0	COG1574@1|root,COG1574@2|Bacteria,3Y453@57723|Acidobacteria,2JIB6@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_3115840_9	1121920.AUAU01000009_gene1864	3.35e-65	246.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3115840_18	1545915.JROG01000004_gene2039	7.203e-13	82.0	COG5010@1|root,COG5010@2|Bacteria,1R7S3@1224|Proteobacteria,2TUMP@28211|Alphaproteobacteria,2K076@204457|Sphingomonadales	204457|Sphingomonadales	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
HFD2_k127_3115840_6	1121920.AUAU01000009_gene1864	3.54e-70	261.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3115840_14	204669.Acid345_4315	2.475e-34	139.0	COG0251@1|root,COG0251@2|Bacteria,3Y57T@57723|Acidobacteria,2JJQ3@204432|Acidobacteriia	204432|Acidobacteriia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_3115840_10	1121428.DESHY_50085___1	5.088e-57	214.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,261JW@186807|Peptococcaceae	186801|Clostridia	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3115840_15	1267534.KB906757_gene926	5.944e-20	100.0	COG0308@1|root,COG0308@2|Bacteria,3Y7E9@57723|Acidobacteria,2JMED@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_3121670_0	204669.Acid345_3931	1.745e-119	391.0	COG3033@1|root,COG3033@2|Bacteria,3Y3QK@57723|Acidobacteria	57723|Acidobacteria	E	Beta-eliminating lyase	-	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD2_k127_3121670_1	401053.AciPR4_2596	3.456e-79	271.0	COG1363@1|root,COG1363@2|Bacteria,3Y2Y3@57723|Acidobacteria,2JKCI@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HFD2_k127_312394_0	1047013.AQSP01000134_gene1378	7.806e-72	252.0	COG1192@1|root,COG1192@2|Bacteria,2NP2C@2323|unclassified Bacteria	2|Bacteria	D	Cobyrinic acid ac-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD2_k127_312394_1	1502851.FG93_04728	7.664e-37	150.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,3JTGY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD2_k127_3127190_2	118163.Ple7327_1858	1.539e-100	335.0	COG1131@1|root,COG1131@2|Bacteria,1G11U@1117|Cyanobacteria,3VI2H@52604|Pleurocapsales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_3127190_6	395961.Cyan7425_4024	4.528e-63	226.0	COG1277@1|root,COG1277@2|Bacteria,1G272@1117|Cyanobacteria,3KH1I@43988|Cyanothece	1117|Cyanobacteria	S	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
HFD2_k127_3127190_1	880073.Calab_2472	6.351e-112	380.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
HFD2_k127_3127190_9	46234.ANA_C13388	2.236e-17	94.0	COG3170@1|root,COG3170@2|Bacteria,1G6DU@1117|Cyanobacteria,1HN5Y@1161|Nostocales	1117|Cyanobacteria	NU	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HFD2_k127_3127190_8	880073.Calab_3784	4.947e-21	100.0	COG1986@1|root,COG1986@2|Bacteria,2NS1I@2323|unclassified Bacteria	2|Bacteria	F	Protein of unknown function DUF84	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
HFD2_k127_3127190_0	1123393.KB891316_gene2018	2.388e-157	503.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2VP5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3127190_4	1340493.JNIF01000004_gene501	1.014e-77	265.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HFD2_k127_3127190_5	330214.NIDE0246	1.155e-63	233.0	COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD2_k127_3127190_3	1340493.JNIF01000003_gene2958	2.882e-98	333.0	COG2605@1|root,COG2605@2|Bacteria,3Y56A@57723|Acidobacteria	57723|Acidobacteria	S	GHMP kinases N terminal domain	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_3127190_7	401053.AciPR4_1940	4.457e-35	146.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria,2JJ3Q@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_315330_4	251221.35212578	5.684e-05	46.0	COG1044@1|root,COG1044@2|Bacteria,1G04G@1117|Cyanobacteria	1117|Cyanobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HFD2_k127_315330_3	204669.Acid345_1936	3.925e-36	142.0	2C62N@1|root,32TCB@2|Bacteria,3Y55K@57723|Acidobacteria,2JP1N@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_315330_0	1047013.AQSP01000135_gene1591	1.231e-117	397.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_315330_1	935836.JAEL01000111_gene686	2.207e-93	314.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_315330_2	204669.Acid345_1937	2.613e-78	281.0	COG0617@1|root,COG0617@2|Bacteria,3Y3U6@57723|Acidobacteria,2JIF4@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	-	-	-	-	-	-	-	-	-	-	-	-	PolyA_pol
HFD2_k127_3182428_4	204669.Acid345_2615	4.259e-74	261.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,3Y2UC@57723|Acidobacteria,2JIDD@204432|Acidobacteriia	204432|Acidobacteriia	V	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
HFD2_k127_3182428_1	518766.Rmar_0925	4.353e-226	734.0	COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
HFD2_k127_3182428_7	204669.Acid345_2912	7.2e-14	78.0	28YRV@1|root,2ZKJ9@2|Bacteria,3Y8YG@57723|Acidobacteria,2JNVB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3182428_5	273526.SMDB11_3048	7.073e-45	168.0	COG2103@1|root,COG2103@2|Bacteria,1MVDR@1224|Proteobacteria,1RN3P@1236|Gammaproteobacteria,4003H@613|Serratia	1236|Gammaproteobacteria	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
HFD2_k127_3182428_6	1118054.CAGW01000068_gene1878	4.593e-36	141.0	COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,4HBWP@91061|Bacilli,26QZT@186822|Paenibacillaceae	91061|Bacilli	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
HFD2_k127_3182428_2	204669.Acid345_2108	1.987e-167	535.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria,2JI7D@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HFD2_k127_3182428_0	639030.JHVA01000001_gene1649	5e-324	1029.0	COG4932@1|root,COG4932@2|Bacteria,3Y9AV@57723|Acidobacteria,2JP0F@204432|Acidobacteriia	204432|Acidobacteriia	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_3182428_3	234267.Acid_1376	4.525e-81	277.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_3188999_0	204669.Acid345_1624	0.0	1091.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_3189137_3	1379698.RBG1_1C00001G0608	6.841e-60	230.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
HFD2_k127_3189137_5	1267533.KB906735_gene5070	3.003e-10	71.0	2C730@1|root,32UQY@2|Bacteria,3Y59Z@57723|Acidobacteria,2JJP2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3189137_6	428125.CLOLEP_00729	2.412e-07	59.0	2E3AT@1|root,32YAA@2|Bacteria,1V69D@1239|Firmicutes,24W7M@186801|Clostridia	186801|Clostridia	L	Restriction endonuclease BglII	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc-BglII
HFD2_k127_3189137_4	1117108.PAALTS15_19618	2.477e-35	142.0	COG0350@1|root,COG1600@1|root,COG0350@2|Bacteria,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,4HAEW@91061|Bacilli,26R4Y@186822|Paenibacillaceae	91061|Bacilli	C	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
HFD2_k127_3189137_2	316067.Geob_0076	3.463e-63	231.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42S40@68525|delta/epsilon subdivisions,2WNAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_3189137_0	204669.Acid345_4377	3.395e-125	413.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JM41@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3189137_1	1340493.JNIF01000003_gene4682	3.968e-112	377.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3191900_0	234267.Acid_4619	1.368e-212	674.0	COG0531@1|root,COG0531@2|Bacteria,3Y2RG@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_3191900_1	1238182.C882_2436	1.407e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,2JRV6@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3191900_2	714943.Mucpa_1721	6.377e-31	127.0	COG4251@1|root,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,1IQJS@117747|Sphingobacteriia	976|Bacteroidetes	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_3196339_0	234267.Acid_7263	1.699e-208	655.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_3196339_1	357808.RoseRS_2426	1.485e-18	91.0	COG1574@1|root,COG1574@2|Bacteria,2G85Y@200795|Chloroflexi,37716@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_3200473_0	401053.AciPR4_0408	2.894e-173	561.0	COG1472@1|root,COG1472@2|Bacteria,3Y3H7@57723|Acidobacteria,2JIAJ@204432|Acidobacteriia	204432|Acidobacteriia	G	hydrolase family, 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HFD2_k127_3200473_1	1499967.BAYZ01000136_gene55	1.492e-58	218.0	COG1089@1|root,COG1089@2|Bacteria,2NP6U@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	wcbK	-	1.1.1.281,4.2.1.47	ko:K01711,ko:K15856	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888,R03397,R03399	RC00182,RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_3200473_2	28532.XP_010557675.1	6.561e-18	85.0	COG1089@1|root,KOG1372@2759|Eukaryota,37HE5@33090|Viridiplantae,3G75T@35493|Streptophyta,3HVN8@3699|Brassicales	35493|Streptophyta	G	GDP-mannose	-	GO:0000902,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008446,GO:0009058,GO:0009225,GO:0009226,GO:0009653,GO:0009826,GO:0009987,GO:0016043,GO:0016049,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0032502,GO:0032989,GO:0034641,GO:0034654,GO:0040007,GO:0042350,GO:0042351,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046368,GO:0046483,GO:0048589,GO:0048856,GO:0048869,GO:0055086,GO:0060560,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_3207381_0	880072.Desac_2282	2.884e-47	180.0	COG1752@1|root,COG1752@2|Bacteria,1PGY0@1224|Proteobacteria,42MKJ@68525|delta/epsilon subdivisions,2WK4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_3207381_1	1396418.BATQ01000051_gene59	2.591e-45	181.0	COG3203@1|root,COG3203@2|Bacteria,46SY8@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HFD2_k127_3207381_2	1121440.AUMA01000006_gene1594	1.045e-43	166.0	COG3945@1|root,COG3945@2|Bacteria,1RG8J@1224|Proteobacteria,42S6P@68525|delta/epsilon subdivisions,2WNYW@28221|Deltaproteobacteria,2MCW2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_3207381_3	1249480.B649_07060	2.512e-25	111.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_3207381_4	247490.KSU1_C1567	7.202e-19	92.0	COG2846@1|root,COG2846@2|Bacteria,2J2QY@203682|Planctomycetes	203682|Planctomycetes	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HFD2_k127_3207869_18	596152.DesU5LDRAFT_0659	7.863e-15	85.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2M7QR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM cell wall hydrolase autolysin	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
HFD2_k127_3207869_19	96561.Dole_1616	4.386e-13	78.0	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,2MKUK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HFD2_k127_3207869_5	246194.CHY_0314	6.291e-92	310.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,42F6J@68295|Thermoanaerobacterales	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
HFD2_k127_3207869_14	235909.GK2665	1.34e-45	172.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4HCP6@91061|Bacilli,1WF41@129337|Geobacillus	91061|Bacilli	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD2_k127_3207869_6	234267.Acid_3784	6.964e-90	301.0	COG0177@1|root,COG0177@2|Bacteria,3Y3QD@57723|Acidobacteria	57723|Acidobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD2_k127_3207869_17	309807.SRU_0461	2.68e-24	110.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	-	3.5.4.13,3.6.1.23	ko:K01494,ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R00568,R02100,R02325,R11896	RC00002,RC00074	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD2_k127_3207869_10	1267534.KB906757_gene930	3.296e-62	224.0	COG1595@1|root,COG1595@2|Bacteria,3Y7S5@57723|Acidobacteria,2JMWY@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3207869_13	1267535.KB906767_gene2777	7.256e-53	190.0	2BVXR@1|root,32QYG@2|Bacteria,3Y86A@57723|Acidobacteria	57723|Acidobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD2_k127_3207869_16	1267535.KB906767_gene2776	5.205e-28	117.0	2C9TJ@1|root,2ZFZD@2|Bacteria,3Y970@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3207869_7	330214.NIDE0018	3.167e-83	282.0	COG1018@1|root,COG1018@2|Bacteria,3J196@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3207869_15	1278073.MYSTI_01200	1.177e-36	144.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,42VZX@68525|delta/epsilon subdivisions,2WYIT@28221|Deltaproteobacteria,2YW0H@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_3207869_0	1382359.JIAL01000001_gene678	2.468e-285	882.0	COG0719@1|root,COG0719@2|Bacteria,3Y2IX@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD2_k127_3207869_2	1382359.JIAL01000001_gene679	1.149e-132	426.0	COG0396@1|root,COG0396@2|Bacteria,3Y3S4@57723|Acidobacteria	57723|Acidobacteria	O	ABC transporter	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HFD2_k127_3207869_3	671143.DAMO_2381	1.995e-122	407.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
HFD2_k127_3207869_1	483219.LILAB_02825	6.62e-179	582.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HFD2_k127_3207869_12	215803.DB30_6996	2.634e-55	202.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,4331F@68525|delta/epsilon subdivisions,2WXKR@28221|Deltaproteobacteria,2YY54@29|Myxococcales	28221|Deltaproteobacteria	C	SUF system FeS assembly protein	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_3207869_9	1382359.JIAL01000001_gene683	9.628e-63	222.0	COG2151@1|root,COG2151@2|Bacteria,3Y5G8@57723|Acidobacteria,2JP2G@204432|Acidobacteriia	204432|Acidobacteriia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HFD2_k127_3207869_11	204669.Acid345_2596	2.843e-59	214.0	2C80W@1|root,330EI@2|Bacteria,3Y5KA@57723|Acidobacteria,2JNFE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3207869_4	1267533.KB906736_gene947	6.991e-99	332.0	COG1994@1|root,COG1994@2|Bacteria,3Y48W@57723|Acidobacteria,2JJ1P@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3207869_20	663932.KB902575_gene2899	0.0001516	48.0	2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ETC complex I subunit	MA20_30235	-	1.6.5.3	ko:K00329	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	ETC_C1_NDUFA4
HFD2_k127_3207869_8	391038.Bphy_2359	1.582e-75	256.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_3214432_2	880073.Calab_0034	1.231e-59	228.0	COG3408@1|root,COG3408@2|Bacteria,2NPVQ@2323|unclassified Bacteria	2|Bacteria	G	Trehalase	-	-	-	ko:K03931	-	-	-	-	ko00000	-	GH63	-	Glyco_hydro_63,Trehalase
HFD2_k127_3214432_1	204669.Acid345_2162	2.704e-89	307.0	COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria	57723|Acidobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
HFD2_k127_3214432_3	1267534.KB906757_gene1034	1.497e-32	144.0	COG0526@1|root,COG0526@2|Bacteria,3Y4MM@57723|Acidobacteria,2JJCE@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_3214432_0	661478.OP10G_1986	1.908e-93	323.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3,Beta-lactamase
HFD2_k127_321488_1	401053.AciPR4_2596	8.506e-66	236.0	COG1363@1|root,COG1363@2|Bacteria,3Y2Y3@57723|Acidobacteria,2JKCI@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HFD2_k127_321488_0	518766.Rmar_2417	4.218e-68	239.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1FJRD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HFD2_k127_3240625_0	1120972.AUMH01000015_gene1328	1.989e-78	271.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HB0J@91061|Bacilli,2785Q@186823|Alicyclobacillaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	fadE	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_3240625_1	1382306.JNIM01000001_gene2082	6.686e-50	187.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene2082|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3251899_2	1340493.JNIF01000004_gene785	2.388e-46	175.0	COG0115@1|root,COG0115@2|Bacteria,3Y6HY@57723|Acidobacteria	57723|Acidobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_3251899_3	1185876.BN8_00717	2.225e-05	51.0	COG2730@1|root,COG2730@2|Bacteria,4NXWZ@976|Bacteroidetes,47WUS@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3251899_0	297246.lpp0868	8.563e-101	346.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1JDR9@118969|Legionellales	118969|Legionellales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD2_k127_3251899_1	204669.Acid345_2969	8.438e-55	198.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HFD2_k127_3286359_18	713586.KB900536_gene1774	1.865e-09	59.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria	1224|Proteobacteria	J	50s ribosomal protein l31	rpmE	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD2_k127_3286359_19	240015.ACP_2499	1.64e-08	66.0	2CEWM@1|root,2ZFXW@2|Bacteria,3Y902@57723|Acidobacteria,2JNNH@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3286359_7	240015.ACP_2498	1.232e-89	308.0	COG1131@1|root,COG1131@2|Bacteria,3Y50U@57723|Acidobacteria,2JM9C@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_3286359_15	682795.AciX8_4306	5.115e-40	151.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria,2JK5T@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD2_k127_3286359_20	1198114.AciX9_0481	9.075e-05	51.0	2C5N9@1|root,32RFX@2|Bacteria,3Y4SQ@57723|Acidobacteria,2JJEZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3286359_4	5127.CCT67725	2.48e-109	365.0	COG1087@1|root,KOG1371@2759|Eukaryota,39KCQ@33154|Opisthokonta,3PBHS@4751|Fungi,3RN10@4890|Ascomycota,21D2X@147550|Sordariomycetes,3TKEP@5125|Hypocreales,1FVEQ@110618|Nectriaceae	4751|Fungi	M	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
HFD2_k127_3286359_1	879212.DespoDRAFT_03349	1.678e-155	502.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MHMX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_3286359_3	278963.ATWD01000001_gene2193	1.541e-145	490.0	COG0457@1|root,COG0457@2|Bacteria,3Y6J0@57723|Acidobacteria,2JKHK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HFD2_k127_3286359_13	926566.Terro_2819	1.364e-50	187.0	COG1269@1|root,COG1269@2|Bacteria,3Y565@57723|Acidobacteria,2JMUB@204432|Acidobacteriia	204432|Acidobacteriia	C	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485
HFD2_k127_3286359_6	1267534.KB906757_gene894	5.677e-93	315.0	COG1269@1|root,COG1269@2|Bacteria,3Y7E1@57723|Acidobacteria,2JKI6@204432|Acidobacteriia	204432|Acidobacteriia	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HFD2_k127_3286359_9	290397.Adeh_2651	5.575e-65	235.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_3286359_10	1382359.JIAL01000001_gene945	1.602e-60	215.0	COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria,2JJMM@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_3286359_17	1382359.JIAL01000001_gene944	1.69e-32	145.0	2EF70@1|root,33901@2|Bacteria,3Y5Q5@57723|Acidobacteria,2JJZV@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3286359_5	401053.AciPR4_0585	2.356e-107	366.0	COG3206@1|root,COG3206@2|Bacteria,3Y3JI@57723|Acidobacteria,2JI13@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HFD2_k127_3286359_8	278963.ATWD01000001_gene2187	6.209e-89	304.0	COG3267@1|root,COG3267@2|Bacteria,3Y6P4@57723|Acidobacteria,2JKNX@204432|Acidobacteriia	204432|Acidobacteriia	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD2_k127_3286359_11	1382359.JIAL01000001_gene941	3.926e-54	201.0	COG0489@1|root,COG0489@2|Bacteria,3Y59M@57723|Acidobacteria,2JJS6@204432|Acidobacteriia	204432|Acidobacteriia	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HFD2_k127_3286359_2	1267534.KB906757_gene888	2.715e-153	496.0	COG2148@1|root,COG2148@2|Bacteria,3Y4JY@57723|Acidobacteria,2JJ8R@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HFD2_k127_3286359_0	1499967.BAYZ01000123_gene2532	2.924e-163	534.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_3286359_16	378806.STAUR_3697	8.584e-35	153.0	COG2244@1|root,COG2244@2|Bacteria,1P0EB@1224|Proteobacteria,431IR@68525|delta/epsilon subdivisions,2WW7D@28221|Deltaproteobacteria,2YVY7@29|Myxococcales	28221|Deltaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HFD2_k127_3286359_12	404589.Anae109_2607	5.627e-53	212.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42UIR@68525|delta/epsilon subdivisions,2WTWT@28221|Deltaproteobacteria,2Z2XU@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_3286359_14	880073.Calab_2313	1.805e-50	204.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wxcD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_3297215_1	1173028.ANKO01000017_gene259	7.25e-39	149.0	COG0407@1|root,COG0407@2|Bacteria,1G0M2@1117|Cyanobacteria,1H8IS@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD2_k127_3297215_0	945713.IALB_0538	5.74e-123	414.0	COG0635@1|root,COG0635@2|Bacteria	2|Bacteria	H	coproporphyrinogen oxidase activity	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	HemN_C,Radical_SAM
HFD2_k127_3316487_0	575540.Isop_1183	1.996e-55	202.0	COG4798@1|root,COG4798@2|Bacteria,2IZ87@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,Methyltransf_25
HFD2_k127_3316487_2	234267.Acid_3525	5.329e-41	154.0	COG3801@1|root,COG3801@2|Bacteria,3Y5K2@57723|Acidobacteria	57723|Acidobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD2_k127_3316487_1	1267534.KB906759_gene1858	9.262e-44	162.0	COG0567@1|root,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria,2JICX@204432|Acidobacteriia	204432|Acidobacteriia	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoGdeHyase_C,Transket_pyr
HFD2_k127_3337103_1	204669.Acid345_0282	4.234e-67	233.0	COG1940@1|root,COG1940@2|Bacteria,3Y3B2@57723|Acidobacteria,2JIYY@204432|Acidobacteriia	204432|Acidobacteriia	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_3337103_2	1340493.JNIF01000003_gene1493	9.709e-25	110.0	2E32R@1|root,32Y2Y@2|Bacteria,3Y5RV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3337103_0	234267.Acid_7035	2.175e-169	546.0	COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD2_k127_3338726_0	330214.NIDE3701	1.138e-163	521.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
HFD2_k127_3338726_1	330214.NIDE0159	1.256e-56	202.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	yurZ	-	2.3.1.12,4.1.1.44	ko:K00627,ko:K01607	ko00010,ko00020,ko00362,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00020,map00362,map00620,map01100,map01110,map01120,map01130,map01200,map01220	M00307	R00209,R02569,R03470	RC00004,RC00938,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CMD
HFD2_k127_3338726_2	459495.SPLC1_S590530	6.678e-40	151.0	COG0500@1|root,COG2226@2|Bacteria,1G29G@1117|Cyanobacteria,1HABE@1150|Oscillatoriales	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
HFD2_k127_3340961_5	204669.Acid345_1569	8.475e-32	131.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD2_k127_3340961_4	204669.Acid345_2164	1.284e-39	154.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_3340961_2	621372.ACIH01000022_gene4210	3.851e-98	329.0	COG1028@1|root,COG1028@2|Bacteria,1VREU@1239|Firmicutes,4HUY2@91061|Bacilli,26WDM@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_3340961_3	379066.GAU_1739	2.833e-55	200.0	2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3340961_0	234267.Acid_0830	4.204e-248	781.0	COG2936@1|root,COG2936@2|Bacteria,3Y2WR@57723|Acidobacteria	57723|Acidobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD2_k127_3340961_1	107636.JQNK01000009_gene3060	4.025e-221	718.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,36XU2@31993|Methylocystaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,Acyltransferase,PP-binding
HFD2_k127_3340961_6	926566.Terro_2880	1.25e-27	119.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3340961_7	204669.Acid345_0245	1.504e-12	68.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_3365297_6	204669.Acid345_3768	0.0001765	46.0	COG0457@1|root,COG0457@2|Bacteria,3Y5A8@57723|Acidobacteria,2JNC1@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
HFD2_k127_3365297_3	278963.ATWD01000001_gene1772	2.865e-58	224.0	COG0457@1|root,COG0457@2|Bacteria,3Y2VC@57723|Acidobacteria,2JHR2@204432|Acidobacteriia	204432|Acidobacteriia	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HFD2_k127_3365297_0	1047013.AQSP01000128_gene428	2.176e-98	338.0	COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria	2|Bacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
HFD2_k127_3365297_5	644548.SCNU_05476	0.0001622	48.0	COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria,4GH0I@85026|Gordoniaceae	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_3365297_1	909663.KI867150_gene1676	2.125e-88	299.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_3365297_4	1382359.JIAL01000001_gene2284	1.216e-12	76.0	COG3087@1|root,COG3087@2|Bacteria,3Y4WI@57723|Acidobacteria,2JJMG@204432|Acidobacteriia	204432|Acidobacteriia	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HFD2_k127_3365297_2	204669.Acid345_2341	2.667e-87	306.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria,2JKVC@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_3367115_1	204669.Acid345_4748	1.25e-77	265.0	COG1428@1|root,COG1428@2|Bacteria,3Y759@57723|Acidobacteria,2JMB9@204432|Acidobacteriia	204432|Acidobacteriia	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
HFD2_k127_3367115_4	378806.STAUR_2934	3.651e-07	58.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2YX39@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg
HFD2_k127_3367115_5	857087.Metme_2552	2.145e-05	57.0	2AEFS@1|root,314AU@2|Bacteria,1RKTV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3367115_2	97138.C820_01573	6.389e-72	257.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,36W6F@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_3367115_0	1267535.KB906767_gene3338	6.414e-102	347.0	COG1446@1|root,COG1446@2|Bacteria,3Y2Y8@57723|Acidobacteria,2JIW3@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.5.1.26	ko:K01444	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Asparaginase_2
HFD2_k127_3367115_3	1244869.H261_14525	2.376e-33	134.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,2JQVK@204441|Rhodospirillales	204441|Rhodospirillales	S	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_3370865_0	886293.Sinac_2689	2.633e-85	305.0	COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
HFD2_k127_3376857_0	1303518.CCALI_01862	3.206e-103	351.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278,ko:K06889	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	PD40,Peptidase_S9
HFD2_k127_3376857_3	204669.Acid345_3995	8.04e-34	137.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria,2JJ9R@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_3376857_4	204669.Acid345_3996	5.875e-21	96.0	2CDNF@1|root,2ZTQP@2|Bacteria,3Y955@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3376857_1	240015.ACP_0929	2.54e-99	328.0	COG2057@1|root,COG2057@2|Bacteria,3Y3EC@57723|Acidobacteria,2JIV4@204432|Acidobacteriia	204432|Acidobacteriia	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_3376857_2	204669.Acid345_1163	1.02e-39	149.0	COG1788@1|root,COG1788@2|Bacteria,3Y3R1@57723|Acidobacteria,2JISA@204432|Acidobacteriia	204432|Acidobacteriia	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_3396512_1	234267.Acid_4828	1.189e-39	148.0	COG0652@1|root,COG0652@2|Bacteria,3Y4CX@57723|Acidobacteria	57723|Acidobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_3396512_2	1051632.TPY_0443	3.985e-39	153.0	COG1853@1|root,COG1853@2|Bacteria,1V1X6@1239|Firmicutes	1239|Firmicutes	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD2_k127_3396512_0	485916.Dtox_2632	4.777e-121	398.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
HFD2_k127_3399296_0	861299.J421_1410	2.907e-124	412.0	COG0624@1|root,COG0624@2|Bacteria,1ZSYH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_3399296_4	146922.JOFU01000002_gene7662	1.662e-05	55.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3399296_2	1382359.JIAL01000001_gene676	6.983e-32	134.0	2E2K5@1|root,32XPI@2|Bacteria,3Y59K@57723|Acidobacteria,2JP1H@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3399296_1	204669.Acid345_0620	3.468e-89	306.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_3399296_3	1267535.KB906767_gene3171	1.435e-06	54.0	2EGFY@1|root,30MEN@2|Bacteria,3Y7VF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_344744_0	1183438.GKIL_4354	2.099e-181	591.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_344744_1	1267535.KB906767_gene1124	2.274e-41	155.0	COG0577@1|root,COG0577@2|Bacteria,3Y6YF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_3450147_5	404589.Anae109_0372	1.352e-33	134.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,2YXEI@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HFD2_k127_3450147_0	1382359.JIAL01000001_gene729	2.545e-181	580.0	COG0133@1|root,COG0133@2|Bacteria,3Y45B@57723|Acidobacteria,2JIVM@204432|Acidobacteriia	204432|Acidobacteriia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_3450147_4	1267533.KB906737_gene1983	1.229e-37	147.0	2DQZX@1|root,339KD@2|Bacteria,3Y8FP@57723|Acidobacteria	57723|Acidobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HFD2_k127_3450147_1	234267.Acid_7887	2.406e-81	279.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria	57723|Acidobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HFD2_k127_3450147_6	526227.Mesil_1269	9.45e-09	62.0	COG1605@1|root,COG2876@1|root,COG1605@2|Bacteria,COG2876@2|Bacteria,1WJ86@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	chorismate mutase domain of gram positive AroA protein	-	-	2.5.1.54,5.4.99.5	ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
HFD2_k127_3450147_3	204669.Acid345_1162	4.825e-48	183.0	COG0287@1|root,COG0287@2|Bacteria,3Y4CK@57723|Acidobacteria,2JJ49@204432|Acidobacteriia	204432|Acidobacteriia	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HFD2_k127_3450147_2	1279009.ADICEAN_02337	6.808e-60	210.0	COG1788@1|root,COG1788@2|Bacteria,4NF3T@976|Bacteroidetes,47KQE@768503|Cytophagia	976|Bacteroidetes	I	3-oxoacid CoA-transferase, a subunit	scoA	-	2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9	ko:K01027,ko:K01028,ko:K01031,ko:K01034	ko00072,ko00280,ko00310,ko00362,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00362,map00627,map00640,map00650,map01100,map01120,map02020	-	R00410,R01179,R01359,R01365,R02990,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_3452468_2	1047013.AQSP01000091_gene644	2.48e-185	585.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
HFD2_k127_3452468_6	1047013.AQSP01000091_gene643	4.251e-74	259.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
HFD2_k127_3452468_0	246194.CHY_0732	2.018e-239	755.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HFD2_k127_3452468_9	1262915.BN574_00309	5.729e-41	160.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,4H42Q@909932|Negativicutes	909932|Negativicutes	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HFD2_k127_3452468_10	867903.ThesuDRAFT_00144	2.049e-19	92.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HFD2_k127_3452468_4	204669.Acid345_1265	7.455e-114	379.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria,2JJTZ@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_3452468_3	204669.Acid345_1264	4.91e-185	587.0	COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria,2JI87@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_3452468_8	204669.Acid345_1263	1.569e-46	172.0	COG0698@1|root,COG0698@2|Bacteria,3Y50S@57723|Acidobacteria,2JJEK@204432|Acidobacteriia	2|Bacteria	G	Ribose/Galactose Isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	5.3.1.26,5.3.1.34,5.3.1.6	ko:K01808,ko:K01819,ko:K21911	ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R03240,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3353	DUF3666,LacAB_rpiB
HFD2_k127_3452468_5	234267.Acid_3369	1.965e-74	276.0	2E93F@1|root,333CD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3452468_7	234267.Acid_6753	8.06e-59	217.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria,3Y4DW@57723|Acidobacteria	2|Bacteria	T	Histidine kinase-like ATPase domain	rsbW	-	2.7.11.1,3.4.21.53	ko:K01338,ko:K04757,ko:K06379,ko:K08282,ko:K17752	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko03021	-	-	-	HATPase_c_2,HTH_8,Response_reg
HFD2_k127_3452468_1	886293.Sinac_7190	5.25e-207	679.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
HFD2_k127_3463478_2	1267535.KB906767_gene3494	1.681e-47	184.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	wza	-	-	ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_3463478_4	1219084.AP014508_gene341	2.172e-17	89.0	COG0071@1|root,COG0071@2|Bacteria,2GDCG@200918|Thermotogae	200918|Thermotogae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_3463478_1	204669.Acid345_3907	1.101e-164	531.0	COG3667@1|root,COG3667@2|Bacteria,3Y3FP@57723|Acidobacteria,2JITP@204432|Acidobacteriia	204432|Acidobacteriia	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3463478_3	1278073.MYSTI_01887	1.234e-42	163.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,42UWJ@68525|delta/epsilon subdivisions,2WQFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_3463478_0	204669.Acid345_0472	4.553e-166	538.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7
HFD2_k127_3465663_2	1379270.AUXF01000001_gene2740	1.788e-112	375.0	COG1524@1|root,COG1524@2|Bacteria,1ZURJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3465663_1	379066.GAU_2299	1.749e-194	629.0	COG4805@1|root,COG4805@2|Bacteria,1ZUMK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD2_k127_3465663_0	518766.Rmar_0638	9.991e-272	849.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_350254_0	570967.JMLV01000002_gene1584	3.96e-84	292.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,2JRRJ@204441|Rhodospirillales	204441|Rhodospirillales	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD2_k127_350254_2	765911.Thivi_0287	3.861e-17	85.0	COG4251@1|root,COG4251@2|Bacteria,1N1KJ@1224|Proteobacteria,1SD1J@1236|Gammaproteobacteria,1WZD7@135613|Chromatiales	135613|Chromatiales	T	PFAM KaiB domain	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
HFD2_k127_350254_1	886293.Sinac_4913	2.069e-59	222.0	COG4564@1|root,COG4564@2|Bacteria	2|Bacteria	T	Single Cache domain 2	degS	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,sCache_2
HFD2_k127_3524856_3	234267.Acid_1964	5.688e-29	126.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD2_k127_3524856_0	525904.Tter_0214	3.487e-152	493.0	COG0624@1|root,COG0624@2|Bacteria,2NQM8@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	dapE	-	3.5.1.16,3.5.1.18	ko:K01436,ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_3524856_2	1382359.JIAL01000001_gene1983	2.995e-29	122.0	COG2010@1|root,COG2010@2|Bacteria,3Y8QG@57723|Acidobacteria,2JNF2@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_3524856_1	204669.Acid345_4000	5.078e-93	312.0	2CAA3@1|root,2ZJET@2|Bacteria,3Y492@57723|Acidobacteria,2JM13@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3529450_0	234267.Acid_3614	2.732e-155	496.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HFD2_k127_3529450_4	1340493.JNIF01000003_gene2570	1.925e-54	200.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,BAAT_C,DUF676,Hydrolase_4
HFD2_k127_3529450_8	1210884.HG799462_gene8360	3.511e-36	145.0	COG0328@1|root,COG0328@2|Bacteria,2J0TM@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
HFD2_k127_3529450_9	234267.Acid_0817	4.346e-30	129.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HFD2_k127_3529450_5	234267.Acid_2321	4.655e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,3Y45G@57723|Acidobacteria	2|Bacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_3529450_13	398767.Glov_1269	0.0001093	52.0	COG3170@1|root,COG3170@2|Bacteria,1NHGQ@1224|Proteobacteria,42X64@68525|delta/epsilon subdivisions,2WSMQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,zf-HC2
HFD2_k127_3529450_7	234267.Acid_2323	2.148e-37	154.0	COG1040@1|root,COG1040@2|Bacteria,3Y5KW@57723|Acidobacteria	57723|Acidobacteria	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	DZR,PLDc_N
HFD2_k127_3529450_11	204669.Acid345_3872	6.836e-14	74.0	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	pptA	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HFD2_k127_3529450_10	324602.Caur_0229	1.071e-18	93.0	COG3453@1|root,COG3453@2|Bacteria,2GB3Y@200795|Chloroflexi,3778V@32061|Chloroflexia	32061|Chloroflexia	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
HFD2_k127_3529450_6	240015.ACP_0160	1.062e-37	152.0	COG1956@1|root,COG2203@1|root,COG2208@1|root,COG1956@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
HFD2_k127_3529450_3	696281.Desru_2129	3.02e-80	273.0	COG3647@1|root,COG3647@2|Bacteria,1V19Q@1239|Firmicutes,249U7@186801|Clostridia,2628G@186807|Peptococcaceae	186801|Clostridia	S	membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HFD2_k127_3529450_12	313606.M23134_01320	9.677e-06	56.0	COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,47K73@768503|Cytophagia	976|Bacteroidetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292,LolA_like
HFD2_k127_3529450_2	369723.Strop_2630	2.79e-84	292.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria,4DH8E@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD2_k127_3529450_1	1340493.JNIF01000004_gene208	5.893e-154	510.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3533554_3	234267.Acid_2017	2.752e-78	282.0	COG1506@1|root,COG1506@2|Bacteria,3Y2HK@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD2_k127_3533554_0	204669.Acid345_4432	1.546e-182	592.0	COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
HFD2_k127_3533554_1	1379698.RBG1_1C00001G0607	3.82e-162	537.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HFD2_k127_3533554_2	1267535.KB906767_gene4240	5.888e-102	349.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HFD2_k127_3539215_1	234267.Acid_7244	4.524e-61	218.0	COG1413@1|root,COG1413@2|Bacteria,3Y76M@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_3539215_2	234267.Acid_7364	3.552e-54	202.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	liaG3	-	-	-	-	-	-	-	-	-	-	-	DUF1700,DUF2807,DUF4097
HFD2_k127_3539215_0	251221.35211765	7.798e-216	696.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3546709_1	234267.Acid_7333	1.118e-77	266.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD2_k127_3546709_0	204669.Acid345_3562	1.068e-132	445.0	COG1044@1|root,COG1044@2|Bacteria,3Y2ZS@57723|Acidobacteria,2JIC3@204432|Acidobacteriia	204432|Acidobacteriia	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HFD2_k127_3555070_3	913865.DOT_0885	1.036e-17	91.0	COG1215@1|root,COG1215@2|Bacteria,1V3BD@1239|Firmicutes,25BWK@186801|Clostridia,263YF@186807|Peptococcaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_3555070_2	1340493.JNIF01000004_gene530	4.72e-35	146.0	COG0526@1|root,COG0526@2|Bacteria,3Y4UN@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_3555070_0	278963.ATWD01000001_gene3847	4.19e-177	572.0	COG0312@1|root,COG0312@2|Bacteria,3Y3MT@57723|Acidobacteria,2JKR9@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3555070_1	1267534.KB906754_gene3377	2.809e-127	427.0	COG0312@1|root,COG0312@2|Bacteria,3Y3B9@57723|Acidobacteria,2JI5P@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3562237_0	404380.Gbem_2951	2.075e-92	319.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,43TY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Phosphate sensor histidine kinase, HAMP and PAS domain-containing	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HFD2_k127_3597940_3	247490.KSU1_C0925	2.131e-09	61.0	2DRFV@1|root,33BJD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3185
HFD2_k127_3597940_2	269799.Gmet_1208	1.9e-25	108.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Transglycosylase-associated protein	MA20_01300	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_3597940_0	204669.Acid345_3766	1.094e-134	443.0	COG0312@1|root,COG0312@2|Bacteria,3Y7SM@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_3597940_1	204669.Acid345_3767	1.817e-72	246.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_361544_0	234267.Acid_0012	0.0	1316.0	COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria	57723|Acidobacteria	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD2_k127_3640529_2	234267.Acid_7316	1.249e-52	198.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_3640529_0	204669.Acid345_3635	1.567e-194	628.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria,2JHPS@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HFD2_k127_3640529_4	204669.Acid345_3636	1.182e-15	82.0	COG2919@1|root,COG2919@2|Bacteria,3Y4JZ@57723|Acidobacteria,2JJBJ@204432|Acidobacteriia	204432|Acidobacteriia	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
HFD2_k127_3640529_1	926566.Terro_3453	1.513e-81	280.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria,2JHM1@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD2_k127_3640529_3	1382359.JIAL01000001_gene1949	4.776e-40	153.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria,2JJA0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD2_k127_3649582_1	204669.Acid345_4366	6.45e-122	410.0	COG4373@1|root,COG4373@2|Bacteria,3Y318@57723|Acidobacteria,2JIZZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Mu-like prophage FluMu protein gp28	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
HFD2_k127_3649582_4	240015.ACP_2372	2.034e-15	85.0	2E2BC@1|root,32XGM@2|Bacteria,3Y5B5@57723|Acidobacteria,2JJV1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2
HFD2_k127_3649582_3	204669.Acid345_4372	2.28e-52	195.0	COG2932@1|root,COG2932@2|Bacteria,3Y4TJ@57723|Acidobacteria,2JJFQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HFD2_k127_3649582_0	204669.Acid345_0549	2.994e-172	562.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria,2JHZB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HFD2_k127_3649582_2	1121438.JNJA01000006_gene297	2.052e-96	328.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2M9RZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_3652736_2	234267.Acid_7483	5.835e-133	434.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_3652736_8	1267533.KB906736_gene1388	2.97e-37	145.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria,2JJA1@204432|Acidobacteriia	204432|Acidobacteriia	K	MerR HTH family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HFD2_k127_3652736_5	401053.AciPR4_0538	1.033e-60	221.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria,2JI9M@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HFD2_k127_3652736_0	1382359.JIAL01000001_gene2977	2.275e-194	629.0	COG0539@1|root,COG0539@2|Bacteria,3Y3DA@57723|Acidobacteria,2JHS3@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_3652736_7	204669.Acid345_4105	4.411e-38	147.0	COG0776@1|root,COG0776@2|Bacteria,3Y56V@57723|Acidobacteria,2JJMF@204432|Acidobacteriia	204432|Acidobacteriia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_3652736_6	234267.Acid_4300	1.824e-57	203.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HFD2_k127_3652736_1	246194.CHY_1350	1.998e-136	448.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
HFD2_k127_3652736_9	1123226.KB899299_gene3364	5.975e-06	57.0	2E9CG@1|root,333K5@2|Bacteria,1VJEP@1239|Firmicutes,4HQ44@91061|Bacilli,275YM@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIMP
HFD2_k127_3652736_3	204669.Acid345_0057	1.105e-76	271.0	COG0322@1|root,COG0322@2|Bacteria,3Y3HU@57723|Acidobacteria,2JHSF@204432|Acidobacteriia	204432|Acidobacteriia	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3652736_4	3218.PP1S46_300V6.1	1.365e-76	264.0	COG0667@1|root,2S0PI@2759|Eukaryota,37UGN@33090|Viridiplantae,3GP0T@35493|Streptophyta	35493|Streptophyta	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_3675968_1	204669.Acid345_1662	7.888e-119	387.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria,2JIY6@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD2_k127_3675968_2	240015.ACP_0619	8.799e-100	333.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD2_k127_3675968_0	234267.Acid_2355	1.42e-183	593.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_3675968_3	1382359.JIAL01000001_gene2782	1.072e-28	123.0	COG1561@1|root,COG1561@2|Bacteria,3Y2HQ@57723|Acidobacteria,2JIXS@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HFD2_k127_3700696_1	1191523.MROS_1657	1.274e-28	124.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD2_k127_3700696_0	204669.Acid345_4495	2.239e-130	434.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD2_k127_3700696_2	204669.Acid345_1181	6.194e-21	94.0	COG2930@1|root,COG2930@2|Bacteria,3Y4GG@57723|Acidobacteria,2JKH3@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_3701179_0	1267533.KB906738_gene2294	7.302e-126	410.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_3701179_1	204669.Acid345_2341	2.269e-70	248.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria,2JKVC@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_371301_0	1267535.KB906767_gene591	2.549e-85	291.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia	204432|Acidobacteriia	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
HFD2_k127_371301_1	204669.Acid345_1394	3.013e-77	263.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_37134_1	485916.Dtox_1171	1.921e-39	152.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,261Z1@186807|Peptococcaceae	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HFD2_k127_37134_2	1207063.P24_07514	7.196e-16	90.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,2U2X8@28211|Alphaproteobacteria,2JPQ4@204441|Rhodospirillales	204441|Rhodospirillales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HFD2_k127_37134_0	204669.Acid345_3356	9.285e-94	315.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_3740463_1	234267.Acid_4895	7.935e-82	284.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3740463_2	234267.Acid_4895	2.711e-75	265.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3740463_4	1267534.KB906759_gene1706	2.242e-13	80.0	2FE51@1|root,3464Y@2|Bacteria,3Y8E0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3740463_0	234267.Acid_0081	1.099e-91	320.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_3740463_3	1298920.KI911353_gene1714	1.276e-17	87.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,21YVJ@1506553|Lachnoclostridium	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_3746996_1	204669.Acid345_4182	2.52e-100	340.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria,2JHQQ@204432|Acidobacteriia	204432|Acidobacteriia	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD2_k127_3746996_5	246197.MXAN_1632	1.946e-46	177.0	COG3055@1|root,COG4932@1|root,COG3055@2|Bacteria,COG4932@2|Bacteria,1Q2SP@1224|Proteobacteria,438EF@68525|delta/epsilon subdivisions,2X3PG@28221|Deltaproteobacteria,2YWRS@29|Myxococcales	28221|Deltaproteobacteria	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HFD2_k127_3746996_8	290397.Adeh_2899	2.111e-09	70.0	COG0823@1|root,COG0823@2|Bacteria,1NKG5@1224|Proteobacteria	1224|Proteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_3746996_2	1356854.N007_10430	2.408e-91	308.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,2781X@186823|Alicyclobacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD2_k127_3746996_4	240015.ACP_1944	3.096e-59	210.0	COG1733@1|root,COG1733@2|Bacteria,3Y7XV@57723|Acidobacteria,2JN1Y@204432|Acidobacteriia	204432|Acidobacteriia	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD2_k127_3746996_3	375286.mma_1842	4.382e-66	228.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VRD1@28216|Betaproteobacteria,474HU@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_3746996_6	1292034.OR37_03705	1.13e-26	114.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_3746996_0	1382359.JIAL01000001_gene657	8.742e-149	475.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD2_k127_3767452_3	1267535.KB906767_gene4269	5.684e-33	137.0	COG2834@1|root,COG2834@2|Bacteria,3Y51N@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA,LolA_like
HFD2_k127_3767452_1	497964.CfE428DRAFT_3859	1.189e-86	297.0	COG0697@1|root,COG0697@2|Bacteria,46T3I@74201|Verrucomicrobia	74201|Verrucomicrobia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3767452_2	886293.Sinac_2076	1.016e-40	165.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_3767452_0	1173024.KI912148_gene2699	3.038e-113	376.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria,1JIE9@1189|Stigonemataceae	1117|Cyanobacteria	FL	Metal binding domain of Ada	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HFD2_k127_3767452_4	639030.JHVA01000001_gene2880	2.064e-27	127.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD2_k127_3836845_2	234267.Acid_4696	1.843e-18	91.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K03409,ko:K04749,ko:K07122	ko02010,ko02030,map02010,map02030	M00210	-	-	ko00000,ko00001,ko00002,ko02000,ko02035,ko03021	3.A.1.27.3	-	-	STAS,STAS_2
HFD2_k127_3836845_0	234267.Acid_4582	0.0	1071.0	COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria	57723|Acidobacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
HFD2_k127_3836845_1	929562.Emtol_2946	9.885e-167	537.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,47KZQ@768503|Cytophagia	976|Bacteroidetes	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_3868259_0	926550.CLDAP_15490	9.362e-147	471.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_3868259_1	204669.Acid345_4458	8.81e-82	290.0	COG0515@1|root,COG0515@2|Bacteria,3Y8AD@57723|Acidobacteria,2JND1@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_3868259_2	661478.OP10G_4301	2.926e-67	236.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_3868259_5	98439.AJLL01000098_gene1905	5.508e-19	89.0	2DRDY@1|root,33BC0@2|Bacteria,1G9R7@1117|Cyanobacteria,1JMI1@1189|Stigonemataceae	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HFD2_k127_3868259_6	1337936.IJ00_06515	4.035e-13	77.0	2DQ7S@1|root,3355J@2|Bacteria,1GA7T@1117|Cyanobacteria,1HPJ8@1161|Nostocales	1117|Cyanobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
HFD2_k127_3868259_4	251229.Chro_4254	3.495e-34	149.0	COG0500@1|root,COG0500@2|Bacteria,1GR1R@1117|Cyanobacteria	1117|Cyanobacteria	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_3868259_3	1173022.Cri9333_4294	5.148e-62	234.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HFD2_k127_3907755_1	251221.35210936	2.453e-93	313.0	COG1574@1|root,COG1574@2|Bacteria,1G40U@1117|Cyanobacteria	1117|Cyanobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_3907755_2	1057002.KB905370_gene3671	5.596e-22	103.0	COG3212@1|root,COG3212@2|Bacteria,1NPFE@1224|Proteobacteria	1224|Proteobacteria	S	Putative beta-lactamase-inhibitor-like, PepSY-like	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_like
HFD2_k127_3907755_0	1122137.AQXF01000004_gene1784	2.818e-153	502.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_3910056_1	204669.Acid345_0913	1.663e-21	108.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria,2JP4V@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3910056_0	204669.Acid345_3965	1.346e-200	649.0	COG0557@1|root,COG0557@2|Bacteria,3Y3TF@57723|Acidobacteria,2JIM3@204432|Acidobacteriia	204432|Acidobacteriia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD2_k127_394204_5	1122226.AUHX01000001_gene558	1.734e-43	175.0	COG3202@1|root,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,1HWNK@117743|Flavobacteriia	976|Bacteroidetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
HFD2_k127_394204_4	1340493.JNIF01000003_gene3663	7.493e-50	181.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria	57723|Acidobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD2_k127_394204_3	234267.Acid_6711	7.221e-61	222.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
HFD2_k127_394204_2	204669.Acid345_0550	9.9e-94	317.0	COG1446@1|root,COG1446@2|Bacteria,3Y2YJ@57723|Acidobacteria,2JIZ2@204432|Acidobacteriia	204432|Acidobacteriia	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HFD2_k127_394204_1	1379698.RBG1_1C00001G0054	1.185e-205	648.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
HFD2_k127_394204_0	234267.Acid_7675	1.187e-229	725.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_3942536_5	398767.Glov_2399	8.512e-39	149.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD2_k127_3942536_2	398767.Glov_2399	1.552e-64	232.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD2_k127_3942536_3	880073.Calab_0491	1.139e-57	207.0	COG1881@1|root,COG1881@2|Bacteria,2NPDK@2323|unclassified Bacteria	2|Bacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD2_k127_3942536_1	1121904.ARBP01000013_gene313	1.678e-91	310.0	COG3391@1|root,COG3391@2|Bacteria,4NH92@976|Bacteroidetes,47JVD@768503|Cytophagia	976|Bacteroidetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_3942536_6	1121935.AQXX01000112_gene5719	4.023e-08	61.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SYA9@1236|Gammaproteobacteria,1XKG8@135619|Oceanospirillales	135619|Oceanospirillales	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_3942536_0	204669.Acid345_1818	1.297e-185	590.0	COG2403@1|root,COG2403@2|Bacteria,3Y6GM@57723|Acidobacteria	57723|Acidobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3942536_4	671143.DAMO_0075	1.511e-43	165.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_3951003_4	316067.Geob_0200	0.0006373	44.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria,43TDH@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	bamY	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2143	AMP-binding,AMP-binding_C
HFD2_k127_3951003_3	1173028.ANKO01000250_gene2396	0.0001574	51.0	COG1413@1|root,COG5330@1|root,COG1413@2|Bacteria,COG5330@2|Bacteria,1G6AT@1117|Cyanobacteria,1HEPD@1150|Oscillatoriales	1117|Cyanobacteria	C	Leucine rich repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	LRV
HFD2_k127_3951003_0	639030.JHVA01000001_gene411	2.638e-70	247.0	COG0491@1|root,COG0491@2|Bacteria,3Y4DN@57723|Acidobacteria,2JJ36@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_3951003_2	378806.STAUR_1528	7.702e-46	180.0	COG0404@1|root,COG0404@2|Bacteria,1QX3Y@1224|Proteobacteria,43BWD@68525|delta/epsilon subdivisions,2X775@28221|Deltaproteobacteria,2YVVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605,ko:K06980	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
HFD2_k127_3951003_1	240015.ACP_0918	1.967e-60	209.0	COG0377@1|root,COG0377@2|Bacteria,3Y77S@57723|Acidobacteria,2JKZB@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD2_k127_3957872_4	1340493.JNIF01000003_gene4752	1.653e-39	150.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD2_k127_3957872_0	926566.Terro_0534	1.558e-155	519.0	COG2091@1|root,COG2091@2|Bacteria,3Y46J@57723|Acidobacteria,2JHWP@204432|Acidobacteriia	204432|Acidobacteriia	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3957872_2	234267.Acid_7247	1.836e-64	226.0	COG1595@1|root,COG1595@2|Bacteria,3Y815@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3957872_3	234267.Acid_7246	2.205e-61	222.0	2BI39@1|root,32C8D@2|Bacteria,3Y85Y@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3957872_1	639030.JHVA01000001_gene1848	2.308e-76	280.0	COG1413@1|root,COG1413@2|Bacteria,3Y7PB@57723|Acidobacteria	57723|Acidobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_3957872_5	234267.Acid_7244	3.131e-25	112.0	COG1413@1|root,COG1413@2|Bacteria,3Y76M@57723|Acidobacteria	57723|Acidobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_3978558_3	595536.ADVE02000001_gene441	1.866e-06	52.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2TSZW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
HFD2_k127_3978558_1	1144275.COCOR_00985	2.937e-70	256.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2WKWM@28221|Deltaproteobacteria,2YU8T@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HFD2_k127_3978558_0	330214.NIDE3009	2.286e-81	297.0	COG5360@1|root,COG5360@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
HFD2_k127_3978558_2	1244869.H261_15065	5.061e-44	166.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1PVGX@1224|Proteobacteria,2V6W1@28211|Alphaproteobacteria,2JRHE@204441|Rhodospirillales	204441|Rhodospirillales	E	Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
HFD2_k127_4000487_0	1382359.JIAL01000001_gene2735	2.191e-290	920.0	COG0383@1|root,COG0383@2|Bacteria,3Y3ID@57723|Acidobacteria,2JINT@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
HFD2_k127_4000487_1	204669.Acid345_1143	2.167e-48	183.0	COG1874@1|root,COG1874@2|Bacteria,3Y6RS@57723|Acidobacteria,2JM2M@204432|Acidobacteriia	204432|Acidobacteriia	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4005250_2	234267.Acid_0046	5.946e-37	151.0	COG4972@1|root,COG4972@2|Bacteria,3Y4X3@57723|Acidobacteria	57723|Acidobacteria	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD2_k127_4005250_0	204669.Acid345_1576	4.338e-248	775.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_4005250_1	1267535.KB906767_gene3543	1.241e-79	275.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD2_k127_4008189_4	234267.Acid_1490	3.383e-20	91.0	COG3276@1|root,COG3276@2|Bacteria,3Y6R2@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HFD2_k127_4008189_8	204536.SULAZ_0772	9.785e-12	66.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_4008189_7	1158345.JNLL01000001_gene1907	1.414e-13	73.0	COG1826@1|root,COG1826@2|Bacteria,2G4BU@200783|Aquificae	200783|Aquificae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_4008189_2	1267533.KB906740_gene361	8.073e-47	175.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria,2JJH8@204432|Acidobacteriia	204432|Acidobacteriia	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD2_k127_4008189_3	1340493.JNIF01000003_gene1551	1.04e-33	137.0	COG2318@1|root,COG2318@2|Bacteria,3Y503@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_4008189_0	340099.Teth39_0902	2.085e-227	715.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_4008189_5	1340493.JNIF01000003_gene2471	7.5e-17	84.0	2EE2F@1|root,337X5@2|Bacteria,3Y5GQ@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4008189_1	204669.Acid345_3359	2.79e-103	342.0	COG1355@1|root,COG1355@2|Bacteria,3Y5Z0@57723|Acidobacteria,2JNSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HFD2_k127_4020668_2	240015.ACP_1676	4.913e-105	353.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3Y4I2@57723|Acidobacteria,2JIKP@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HFD2_k127_4020668_1	398767.Glov_2172	3.872e-109	361.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD2_k127_4020668_0	269799.Gmet_1276	2.876e-139	452.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,43T0T@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
HFD2_k127_4026136_3	234267.Acid_4874	8.618e-52	187.0	2ED19@1|root,336Y7@2|Bacteria,3Y95N@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4026136_5	1379698.RBG1_1C00001G0653	7.932e-10	69.0	2C3C6@1|root,32RC0@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HFD2_k127_4026136_1	204669.Acid345_3448	1.41e-78	267.0	COG1595@1|root,COG1595@2|Bacteria,3Y4KQ@57723|Acidobacteria,2JJAR@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4026136_4	234267.Acid_7794	7.118e-18	89.0	2E5Q2@1|root,330EP@2|Bacteria,3Y5RC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4026136_2	1267533.KB906741_gene406	3.641e-55	207.0	2B4PH@1|root,31XFS@2|Bacteria,3Y8X7@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HFD2_k127_4026136_0	1379698.RBG1_1C00001G0608	4.015e-88	308.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
HFD2_k127_404775_6	204669.Acid345_2943	5.081e-30	121.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD2_k127_404775_3	204669.Acid345_2944	3.699e-98	327.0	COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria,2JKSV@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	DmsC,Fer4_11
HFD2_k127_404775_4	204669.Acid345_2945	4.022e-62	222.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H,Response_reg
HFD2_k127_404775_0	204669.Acid345_2782	9.683e-194	614.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	2|Bacteria	T	Response regulator receiver	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_404775_2	204669.Acid345_2781	1.21e-101	348.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,HATPase_c,HisKA
HFD2_k127_404775_7	243233.MCA2507	5.963e-25	113.0	COG2346@1|root,COG2346@2|Bacteria,1QBDD@1224|Proteobacteria,1S8K7@1236|Gammaproteobacteria,1XF6Z@135618|Methylococcales	135618|Methylococcales	C	Group 1 truncated hemoglobin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_404775_5	234267.Acid_2436	1.142e-34	140.0	COG3170@1|root,COG3170@2|Bacteria,3Y4RX@57723|Acidobacteria	57723|Acidobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_404775_1	204669.Acid345_0976	6.999e-184	585.0	COG0531@1|root,COG0531@2|Bacteria,3Y3MV@57723|Acidobacteria,2JIZC@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_4048346_0	204669.Acid345_0217	1.376e-90	314.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria,2JI2B@204432|Acidobacteriia	204432|Acidobacteriia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HFD2_k127_4048346_2	1267535.KB906767_gene3478	2.423e-24	111.0	COG1847@1|root,COG1847@2|Bacteria,3Y52C@57723|Acidobacteria,2JJF9@204432|Acidobacteriia	204432|Acidobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	R3H
HFD2_k127_4048346_1	357808.RoseRS_0300	4.983e-44	166.0	COG1943@1|root,COG1943@2|Bacteria,2G88H@200795|Chloroflexi,377A5@32061|Chloroflexia	32061|Chloroflexia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4048346_3	1380367.JIBC01000003_gene4245	5.263e-07	51.0	COG2129@1|root,COG2129@2|Bacteria,1R3TH@1224|Proteobacteria,2U5Q8@28211|Alphaproteobacteria,3ZYM2@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD2_k127_4049310_0	234267.Acid_1116	1.261e-90	307.0	COG0061@1|root,COG0061@2|Bacteria,3Y3E6@57723|Acidobacteria	57723|Acidobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD2_k127_4049310_2	983544.Lacal_2171	2.271e-33	139.0	COG3797@1|root,COG3797@2|Bacteria,4NSKS@976|Bacteroidetes,1I70K@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HFD2_k127_4049310_1	648996.Theam_1717	8.605e-69	242.0	COG1189@1|root,COG1189@2|Bacteria,2G3MN@200783|Aquificae	200783|Aquificae	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD2_k127_4049310_3	102125.Xen7305DRAFT_00010110	1.938e-09	59.0	COG0142@1|root,COG0142@2|Bacteria,1G1H4@1117|Cyanobacteria,3VI35@52604|Pleurocapsales	1117|Cyanobacteria	H	Belongs to the FPP GGPP synthase family	crtE	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_4062543_2	682795.AciX8_4155	0.0	1048.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HFD2_k127_4062543_0	1121422.AUMW01000009_gene3340	0.0	1198.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HFD2_k127_4062543_4	1121422.AUMW01000009_gene3341	1.111e-98	332.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,261PP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
HFD2_k127_4062543_1	240015.ACP_1268	0.0	1145.0	2CDRA@1|root,2Z7QN@2|Bacteria,3Y73N@57723|Acidobacteria,2JMK6@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4062543_3	682795.AciX8_4750	2.16e-289	908.0	COG3408@1|root,COG3408@2|Bacteria,3Y6CR@57723|Acidobacteria,2JM5B@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4062543_5	1280666.ATVS01000034_gene1859	5.087e-09	64.0	COG1409@1|root,COG3533@1|root,COG4412@1|root,COG5263@1|root,COG1409@2|Bacteria,COG3533@2|Bacteria,COG4412@2|Bacteria,COG5263@2|Bacteria,1U157@1239|Firmicutes,25E8B@186801|Clostridia,4BZ1W@830|Butyrivibrio	186801|Clostridia	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,FIVAR,Laminin_G_3
HFD2_k127_4067712_0	204669.Acid345_0484	4.196e-201	634.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_4067712_3	204669.Acid345_0485	7.324e-42	158.0	COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_4067712_2	204669.Acid345_0567	2.381e-63	223.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria,2JJ6A@204432|Acidobacteriia	204432|Acidobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_4067712_1	234267.Acid_7274	6.251e-136	452.0	COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_4067712_4	670487.Ocepr_2170	2.535e-19	99.0	COG1482@1|root,COG1482@2|Bacteria,1WJV9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HFD2_k127_4089101_3	1034943.BN1094_00881	7.199e-06	51.0	2AQ08@1|root,31F55@2|Bacteria,1QCIT@1224|Proteobacteria,1T89I@1236|Gammaproteobacteria,1JGET@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4089101_2	1452718.JBOY01000055_gene1748	2.324e-35	139.0	2DNJV@1|root,32UJ6@2|Bacteria,1N4SS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4089101_1	266264.Rmet_4656	2.771e-37	145.0	COG1359@1|root,COG1359@2|Bacteria,1N1I5@1224|Proteobacteria,2W493@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD2_k127_4089101_0	234267.Acid_5423	1.296e-131	426.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y4NM@57723|Acidobacteria	57723|Acidobacteria	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HFD2_k127_4097114_0	1122604.JONR01000025_gene4602	7.244e-51	197.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_4097114_3	1307436.PBF_07868	2.892e-23	114.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4HDPI@91061|Bacilli,1ZS8C@1386|Bacillus	91061|Bacilli	G	COG4632 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NAGPA,Pur_ac_phosph_N
HFD2_k127_4140660_1	1379698.RBG1_1C00001G1188	6.874e-60	217.0	COG1321@1|root,COG1321@2|Bacteria,2NRDQ@2323|unclassified Bacteria	2|Bacteria	K	FeoA	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HFD2_k127_4140660_2	234267.Acid_0288	3.711e-21	98.0	COG0394@1|root,COG0394@2|Bacteria,3Y8RC@57723|Acidobacteria	57723|Acidobacteria	T	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
HFD2_k127_4140660_0	204669.Acid345_1871	4.723e-63	222.0	COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HFD2_k127_4140660_3	642492.Clole_0477	4.367e-06	48.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia	186801|Clostridia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD2_k127_4148562_0	240015.ACP_2261	8.924e-74	258.0	COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria,2JI11@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_4148562_2	338963.Pcar_0982	3.129e-37	149.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,42TZK@68525|delta/epsilon subdivisions,2WQ2E@28221|Deltaproteobacteria,43SQ1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	CBS,DUF190
HFD2_k127_4148562_3	1009370.ALO_09729	1.335e-25	111.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,4H4YH@909932|Negativicutes	909932|Negativicutes	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HFD2_k127_4148562_1	379066.GAU_2901	5.928e-39	153.0	COG0125@1|root,COG0125@2|Bacteria,1ZUCV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
HFD2_k127_4148562_4	1356854.N007_02335	1.289e-06	53.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,278GH@186823|Alicyclobacillaceae	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HFD2_k127_4224376_0	1267535.KB906767_gene956	1.736e-71	255.0	COG0596@1|root,COG0596@2|Bacteria,3Y89S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_4234817_3	644966.Tmar_1413	1.736e-98	330.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,3WCYS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HFD2_k127_4234817_1	1267534.KB906754_gene2767	3.952e-161	519.0	COG0379@1|root,COG0379@2|Bacteria,3Y328@57723|Acidobacteria,2JHY8@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HFD2_k127_4234817_5	234267.Acid_1194	2.671e-24	107.0	COG4911@1|root,COG4911@2|Bacteria,3Y4VB@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HFD2_k127_4234817_0	278963.ATWD01000002_gene372	7.162e-240	760.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HFD2_k127_4234817_4	1267534.KB906759_gene1908	6.287e-30	131.0	2EBPI@1|root,2ZST6@2|Bacteria,3Y4NS@57723|Acidobacteria,2JJ73@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4234817_2	204669.Acid345_4390	1.465e-99	336.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_4294665_1	204669.Acid345_1213	6.361e-38	145.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_4294665_0	1123376.AUIU01000013_gene1881	1.582e-53	194.0	COG0054@1|root,COG0054@2|Bacteria,3J0QT@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD2_k127_4294665_3	234267.Acid_6222	4.843e-25	113.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria	57723|Acidobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD2_k127_4294665_2	391603.FBALC1_11467	2.383e-25	117.0	COG0457@1|root,COG0457@2|Bacteria,4NJ7M@976|Bacteroidetes,1I0QV@117743|Flavobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_6,TPR_8
HFD2_k127_4294665_4	221103.XP_007847320.1	2.22e-12	70.0	COG0384@1|root,KOG3033@2759|Eukaryota,3A15X@33154|Opisthokonta,3P1U6@4751|Fungi,3VBHS@5204|Basidiomycota,22A4J@155619|Agaricomycetes	4751|Fungi	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HFD2_k127_4304727_0	1303518.CCALI_00397	7.847e-80	278.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	ocd	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD2_k127_4304727_4	694427.Palpr_2152	2.929e-08	58.0	arCOG05093@1|root,339N6@2|Bacteria,4NYIM@976|Bacteroidetes,2FVF5@200643|Bacteroidia,22YYW@171551|Porphyromonadaceae	976|Bacteroidetes	S	Winged helix-turn-helix domain (DUF2582)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2582
HFD2_k127_4304727_2	1121448.DGI_0529	2.091e-30	132.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD2_k127_4304727_3	234267.Acid_0131	1.814e-13	82.0	COG3103@1|root,COG3103@2|Bacteria,3Y3S0@57723|Acidobacteria	57723|Acidobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_8
HFD2_k127_4304727_1	370438.PTH_1386	2.465e-31	126.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_4312989_2	1382359.JIAL01000001_gene1863	7.106e-59	208.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_4312989_0	1499967.BAYZ01000029_gene1223	4.19e-121	423.0	COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria	2|Bacteria	J	Ribonuclease E/G family	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD2_k127_4312989_1	682795.AciX8_3930	8.504e-103	346.0	COG0772@1|root,COG0772@2|Bacteria,3Y3DZ@57723|Acidobacteria,2JINX@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_4312989_3	234267.Acid_4180	2.794e-12	70.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_4319288_4	926566.Terro_4091	9.743e-26	111.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_4319288_1	1267533.KB906735_gene4927	6.524e-138	455.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria,2JIAS@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD2_k127_4319288_0	204669.Acid345_3218	1.901e-289	928.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria,2JKBG@204432|Acidobacteriia	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_4319288_2	1267534.KB906759_gene1855	3.774e-54	205.0	COG0596@1|root,COG0596@2|Bacteria,3Y89S@57723|Acidobacteria,2JNEB@204432|Acidobacteriia	204432|Acidobacteriia	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_4319288_5	1128421.JAGA01000002_gene959	6.286e-25	111.0	COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4319288_3	1379698.RBG1_1C00001G0327	2.408e-35	153.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_4319623_2	330214.NIDE3500	1.169e-31	125.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD2_k127_4319623_0	330214.NIDE3501	1.435e-191	613.0	COG4907@1|root,COG4907@2|Bacteria	2|Bacteria	P	membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
HFD2_k127_4319623_4	351746.Pput_1333	0.0001238	49.0	COG4319@1|root,COG4319@2|Bacteria,1N99A@1224|Proteobacteria,1S7HS@1236|Gammaproteobacteria,1YXCI@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD2_k127_4319623_3	1081640.AGFU01000005_gene1092	7.915e-24	111.0	COG2020@1|root,COG2020@2|Bacteria,1RCWQ@1224|Proteobacteria,2U0I9@28211|Alphaproteobacteria,2K4Z6@204457|Sphingomonadales	204457|Sphingomonadales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HFD2_k127_4319623_1	243164.DET0581	4.548e-69	243.0	COG4912@1|root,COG4912@2|Bacteria,2G8BT@200795|Chloroflexi,34CPY@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
HFD2_k127_4336338_0	1382359.JIAL01000001_gene2689	8.908e-189	614.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD2_k127_4336338_2	204669.Acid345_3857	3.01e-44	185.0	COG2982@1|root,COG2982@2|Bacteria,3Y3Z4@57723|Acidobacteria,2JIBU@204432|Acidobacteriia	204432|Acidobacteriia	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HFD2_k127_4336338_1	234267.Acid_4552	2.755e-62	229.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_4336338_3	1267533.KB906733_gene3234	6.745e-25	109.0	COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria,2JJ95@204432|Acidobacteriia	204432|Acidobacteriia	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD2_k127_4349081_1	401526.TcarDRAFT_2626	9.32e-96	322.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H33Z@909932|Negativicutes	909932|Negativicutes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_4349081_3	1198232.CYCME_1453	1.103e-07	57.0	COG1232@1|root,COG1232@2|Bacteria,1QX3T@1224|Proteobacteria,1T3RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_4349081_2	1198232.CYCME_1453	1.051e-07	59.0	COG1232@1|root,COG1232@2|Bacteria,1QX3T@1224|Proteobacteria,1T3RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_4349081_0	489825.LYNGBM3L_64070	1.527e-104	353.0	COG0438@1|root,COG0438@2|Bacteria,1G1X1@1117|Cyanobacteria,1H8D4@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_4352417_1	1267534.KB906754_gene3319	1.53e-71	250.0	COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria,2JKTQ@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4352417_5	565033.GACE_1709	7.28e-22	101.0	COG4818@1|root,arCOG04344@2157|Archaea,2XZ6C@28890|Euryarchaeota,247B7@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4352417_0	204669.Acid345_1889	2.028e-122	400.0	COG2404@1|root,COG2404@2|Bacteria,3Y98M@57723|Acidobacteria,2JP53@204432|Acidobacteriia	204432|Acidobacteriia	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4352417_2	682795.AciX8_0619	2.082e-45	167.0	COG0393@1|root,COG0393@2|Bacteria,3Y50H@57723|Acidobacteria,2JJIZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HFD2_k127_4352417_4	1267533.KB906739_gene2655	8.248e-37	145.0	COG0346@1|root,COG0346@2|Bacteria,3Y5FC@57723|Acidobacteria,2JJPE@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4352417_3	1267534.KB906755_gene4272	3.196e-40	153.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	AAA_19,Ank,Ank_2,Ank_3,Ank_4,Ank_5,Sigma70_r2,Sigma70_r4,Viral_helicase1
HFD2_k127_4356678_0	857293.CAAU_2593	2.258e-125	413.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,36EHV@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD2_k127_4356678_1	204669.Acid345_1205	4.111e-64	231.0	COG0124@1|root,COG0124@2|Bacteria,3Y3IY@57723|Acidobacteria,2JIRJ@204432|Acidobacteriia	204432|Acidobacteriia	J	synthetase, class II (G H P	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HFD2_k127_4375405_8	204669.Acid345_0049	2.988e-27	115.0	COG3536@1|root,COG3536@2|Bacteria,3Y4UI@57723|Acidobacteria,2JJF2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HFD2_k127_4375405_1	204669.Acid345_1867	8.157e-124	415.0	COG1136@1|root,COG1321@1|root,COG1136@2|Bacteria,COG1321@2|Bacteria,3Y3P4@57723|Acidobacteria,2JHU7@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_4375405_7	269796.Rru_A2805	3.013e-53	201.0	COG0577@1|root,COG0577@2|Bacteria,1R75G@1224|Proteobacteria	1224|Proteobacteria	V	ABC transporter (Permease)	lolE_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_4375405_2	204669.Acid345_1869	9.014e-123	407.0	COG0577@1|root,COG0577@2|Bacteria,3Y36A@57723|Acidobacteria,2JIYT@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_4375405_3	204669.Acid345_1870	4.129e-99	338.0	COG0672@1|root,COG0672@2|Bacteria,3Y3XB@57723|Acidobacteria,2JI3D@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Iron permease FTR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318,FTR1
HFD2_k127_4375405_4	525897.Dbac_1018	5.775e-93	313.0	COG0388@1|root,COG0388@2|Bacteria,1NMSE@1224|Proteobacteria	1224|Proteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_4375405_6	234267.Acid_0626	5.324e-55	221.0	COG1470@1|root,COG2373@1|root,COG2931@1|root,COG3391@1|root,COG4886@1|root,COG5492@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,3Y49I@57723|Acidobacteria	57723|Acidobacteria	N	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,VCBS
HFD2_k127_4375405_5	1382359.JIAL01000001_gene2819	1.138e-72	256.0	COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria,2JIGA@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD2_k127_4375405_9	273068.TTE1392	1.242e-26	113.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,42GW9@68295|Thermoanaerobacterales	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HFD2_k127_4375405_10	696281.Desru_2804	1.757e-21	96.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,263AU@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HFD2_k127_4375405_0	234267.Acid_5181	2.197e-243	770.0	COG0532@1|root,COG3266@1|root,COG0532@2|Bacteria,COG3266@2|Bacteria,3Y3UG@57723|Acidobacteria	57723|Acidobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
HFD2_k127_4377651_5	861299.J421_5582	2.78e-40	156.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD2_k127_4377651_2	1382306.JNIM01000001_gene1024	9.044e-74	264.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_4377651_0	748247.AZKH_0490	2.529e-235	751.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,2KVZ2@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_4377651_3	1382306.JNIM01000001_gene1022	8.055e-49	179.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_4377651_6	330214.NIDE3717	6.116e-28	115.0	COG0607@1|root,COG0607@2|Bacteria,3J17U@40117|Nitrospirae	40117|Nitrospirae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_4377651_1	1382306.JNIM01000001_gene332	3.861e-114	380.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_4377651_4	1118054.CAGW01000061_gene2411	8.237e-47	173.0	COG1024@1|root,COG1024@2|Bacteria,1V0VQ@1239|Firmicutes,4HDR9@91061|Bacilli,274KW@186822|Paenibacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_4380688_1	861299.J421_1935	2.506e-76	267.0	COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4380688_0	234267.Acid_5940	5.736e-253	806.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_4411933_5	1232410.KI421413_gene542	4.029e-09	64.0	COG1605@1|root,COG1605@2|Bacteria,1Q1RX@1224|Proteobacteria,42U9H@68525|delta/epsilon subdivisions,2WQ7P@28221|Deltaproteobacteria,43SMW@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Chorismate mutase type II	-	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
HFD2_k127_4411933_2	1267535.KB906767_gene3079	8.117e-134	438.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HFD2_k127_4411933_4	926566.Terro_1534	8.33e-42	170.0	COG3391@1|root,COG3391@2|Bacteria,3Y3R3@57723|Acidobacteria,2JHUC@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_4411933_0	1267535.KB906767_gene4360	7.99e-179	591.0	COG1449@1|root,COG1449@2|Bacteria,3Y36M@57723|Acidobacteria,2JM7G@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HFD2_k127_4411933_1	926566.Terro_2655	4.416e-176	580.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria,2JI5V@204432|Acidobacteriia	204432|Acidobacteriia	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
HFD2_k127_4411933_3	1410653.JHVC01000001_gene1836	1.203e-75	259.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,24850@186801|Clostridia,36DNP@31979|Clostridiaceae	186801|Clostridia	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HFD2_k127_4493313_1	582515.KR51_00002040	2.442e-25	117.0	COG0730@1|root,COG0730@2|Bacteria,1G8K7@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_4493313_0	1297742.A176_06897	1.707e-100	338.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2YTWM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K02474,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_4544842_0	468059.AUHA01000002_gene563	2.243e-90	331.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
HFD2_k127_4544842_1	1047013.AQSP01000089_gene1181	6.728e-83	308.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cyaJ	-	4.6.1.1	ko:K01768,ko:K02483	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_4690108_0	1042375.AFPL01000043_gene1317	3.497e-185	610.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD2_k127_4719636_1	234267.Acid_7272	1.271e-70	247.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria	57723|Acidobacteria	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_4719636_3	234267.Acid_4496	1.768e-39	152.0	COG2318@1|root,COG2318@2|Bacteria,3Y8UQ@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_4719636_2	1267533.KB906740_gene137	2.359e-43	168.0	29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4719636_4	309799.DICTH_1168	5.956e-27	115.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	yhfA	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HFD2_k127_4719636_0	255470.cbdbA1335	3.485e-84	316.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2G6ND@200795|Chloroflexi,34CT3@301297|Dehalococcoidia	301297|Dehalococcoidia	KT	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HisKA_7TM
HFD2_k127_4736230_2	861299.J421_1942	2.971e-39	149.0	COG1937@1|root,COG1937@2|Bacteria,1ZTZF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HFD2_k127_4736230_0	234267.Acid_4086	3.81e-147	487.0	COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria	57723|Acidobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
HFD2_k127_4736230_1	204669.Acid345_3531	7.599e-62	221.0	COG0845@1|root,COG0845@2|Bacteria,3Y2F6@57723|Acidobacteria,2JI56@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_476850_3	204669.Acid345_4103	2.491e-14	74.0	COG1496@1|root,COG1496@2|Bacteria,3Y3J1@57723|Acidobacteria,2JHKU@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HFD2_k127_476850_1	234267.Acid_7200	1.515e-106	356.0	COG0820@1|root,COG0820@2|Bacteria,3Y3HQ@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_476850_0	234267.Acid_7201	3.5e-176	562.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_476850_2	234267.Acid_3219	3.833e-42	164.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4771528_2	234267.Acid_1568	3.878e-110	364.0	COG3391@1|root,COG3391@2|Bacteria,3Y99Z@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HFD2_k127_4771528_3	667014.Thein_0915	1.985e-27	119.0	COG1267@1|root,COG1267@2|Bacteria,2GHUX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HFD2_k127_4771528_0	278963.ATWD01000001_gene1650	3.622e-153	499.0	COG0621@1|root,COG0621@2|Bacteria,3Y362@57723|Acidobacteria,2JIYW@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
HFD2_k127_4771528_1	204669.Acid345_2146	1.323e-125	430.0	COG1305@1|root,COG1305@2|Bacteria,3Y5BT@57723|Acidobacteria	57723|Acidobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
HFD2_k127_4795839_1	204669.Acid345_3992	3.764e-22	99.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HFD2_k127_4795839_0	204669.Acid345_3989	1.25e-157	507.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_4827151_1	1267535.KB906767_gene3886	6.251e-94	320.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	1267535.KB906767_gene3886|-	T	Osmosensitive K channel His kinase sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4827151_0	1267535.KB906767_gene3885	2.434e-95	333.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	204432|Acidobacteriia	T	Osmosensitive K channel His kinase sensor	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	KdpD,Usp
HFD2_k127_4827151_2	1267535.KB906767_gene626	1.123e-60	213.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria,2JI3W@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HFD2_k127_4830291_1	379066.GAU_0248	2.918e-136	445.0	COG1304@1|root,COG1304@2|Bacteria,1ZUNQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_4830291_0	1382359.JIAL01000001_gene912	2.222e-216	687.0	COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria,2JJVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HFD2_k127_4830291_2	204669.Acid345_1345	1.114e-28	130.0	COG1361@1|root,COG1572@1|root,COG3712@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	DUF11,FecR
HFD2_k127_4847064_1	204669.Acid345_3633	8.671e-86	299.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria,2JHW4@204432|Acidobacteriia	204432|Acidobacteriia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_4847064_0	234267.Acid_7316	2.165e-117	387.0	COG0769@1|root,COG0769@2|Bacteria,3Y38W@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_4852918_1	234267.Acid_0954	2.966e-34	137.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_4852918_0	234267.Acid_0954	8.672e-68	246.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_4852918_2	234267.Acid_6092	4.844e-15	76.0	COG1574@1|root,COG1574@2|Bacteria,3Y7EK@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_4863364_3	278963.ATWD01000001_gene3128	1.262e-25	110.0	COG2234@1|root,COG2234@2|Bacteria,3Y80U@57723|Acidobacteria,2JNYW@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_4863364_0	671143.DAMO_2938	3.845e-266	830.0	COG1274@1|root,COG1274@2|Bacteria,2NQRD@2323|unclassified Bacteria	2|Bacteria	C	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	pckG	-	4.1.1.32,4.1.1.49	ko:K01596,ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003,M00170	R00341,R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP,PEPCK_C,PEPCK_N
HFD2_k127_4863364_4	240015.ACP_2869	4.769e-20	92.0	2CGTB@1|root,343WT@2|Bacteria,3Y8D9@57723|Acidobacteria,2JNEN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4863364_2	204669.Acid345_2467	5.526e-69	251.0	COG1752@1|root,COG1752@2|Bacteria,3Y4B2@57723|Acidobacteria,2JJ4V@204432|Acidobacteriia	57723|Acidobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_4863364_1	1121430.JMLG01000009_gene472	2.715e-233	740.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,247RR@186801|Clostridia,261CD@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD2_k127_4888945_20	485918.Cpin_6496	2.499e-07	53.0	COG1801@1|root,COG1801@2|Bacteria,4NQ30@976|Bacteroidetes,1J07Y@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_4888945_7	234267.Acid_0909	9.516e-80	276.0	COG0565@1|root,COG0565@2|Bacteria,3Y4F6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA rRNA methyltransferase, SpoU	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_4888945_13	522306.CAP2UW1_1698	5.402e-46	169.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2VTTD@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HFD2_k127_4888945_16	258594.RPA3824	1.802e-30	123.0	COG5606@1|root,COG5606@2|Bacteria,1NBW2@1224|Proteobacteria,2UAP1@28211|Alphaproteobacteria,3JZXQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HFD2_k127_4888945_0	1121011.AUCB01000007_gene1247	4.354e-234	744.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1HZ0Y@117743|Flavobacteriia	976|Bacteroidetes	EU	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_4888945_14	443143.GM18_1304	1.498e-45	173.0	2FC9W@1|root,344DJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4888945_2	443143.GM18_1305	2.69e-129	424.0	COG4872@1|root,COG4872@2|Bacteria,1NF4D@1224|Proteobacteria,42XRT@68525|delta/epsilon subdivisions,2WXTA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HFD2_k127_4888945_17	240015.ACP_3118	3.558e-28	116.0	COG1278@1|root,COG1278@2|Bacteria,3Y5GC@57723|Acidobacteria,2JK23@204432|Acidobacteriia	204432|Acidobacteriia	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_4888945_9	204669.Acid345_4197	1.248e-71	252.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria,2JI3J@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4888945_6	304371.MCP_2273	4.531e-99	337.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_4888945_10	1267534.KB906759_gene1657	5.785e-65	230.0	COG4700@1|root,COG4700@2|Bacteria,3Y7KZ@57723|Acidobacteria,2JMTS@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4888945_1	234267.Acid_7026	4.432e-161	538.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	2|Bacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4888945_15	502025.Hoch_6357	7.662e-41	154.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
HFD2_k127_4888945_19	1198114.AciX9_1201	9.379e-11	74.0	COG0457@1|root,COG0457@2|Bacteria	1198114.AciX9_1201|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4888945_8	316067.Geob_1640	1.438e-72	252.0	COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD2_k127_4888945_12	886293.Sinac_3333	6.184e-60	212.0	COG2193@1|root,COG2193@2|Bacteria,2J19B@203682|Planctomycetes	203682|Planctomycetes	P	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_4888945_11	671143.DAMO_1099	3.832e-60	216.0	COG0704@1|root,COG1392@1|root,COG0704@2|Bacteria,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria	2|Bacteria	P	Protein of unknown function DUF47	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU,PhoU_div
HFD2_k127_4888945_5	1449126.JQKL01000036_gene1935	2.767e-101	337.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,2681W@186813|unclassified Clostridiales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_4888945_4	1267535.KB906767_gene584	6.992e-106	350.0	COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia	204432|Acidobacteriia	P	Phosphate transport system permease protein PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_4888945_3	1267535.KB906767_gene585	8.691e-109	358.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_4893229_1	234267.Acid_3369	2.757e-26	118.0	2E93F@1|root,333CD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4893229_0	926569.ANT_10600	6.568e-228	713.0	COG0442@1|root,COG0442@2|Bacteria,2G636@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HFD2_k127_4894258_0	234267.Acid_7470	7.614e-104	363.0	COG5360@1|root,COG5360@2|Bacteria,3Y4P7@57723|Acidobacteria	57723|Acidobacteria	S	Heparinase II/III N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
HFD2_k127_4894258_1	880073.Calab_2313	1.354e-45	174.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wxcD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_4894625_4	945713.IALB_0539	2.964e-37	143.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3734,iSBO_1134.SBO_4018	URO-D
HFD2_k127_4894625_5	1499680.CCFE01000018_gene1409	9.801e-17	90.0	COG0755@1|root,COG0755@2|Bacteria,1U8IP@1239|Firmicutes,4HD6H@91061|Bacilli,1ZBFP@1386|Bacillus	91061|Bacilli	O	cytochrome C	hemX	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678	-	ko:K02497	-	-	-	-	ko00000	-	-	-	Cytochrom_C_asm
HFD2_k127_4894625_2	1163408.UU9_16893	4.052e-84	302.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1X4P8@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HFD2_k127_4894625_1	1125863.JAFN01000001_gene1122	1.547e-92	316.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD2_k127_4894625_3	42256.RradSPS_1755	5.077e-41	162.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4CU1Q@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HFD2_k127_4894625_0	289376.THEYE_A0690	3.85e-143	462.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HFD2_k127_491745_1	204669.Acid345_1729	3.465e-22	102.0	COG1376@1|root,COG1376@2|Bacteria,3Y7TU@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD2_k127_491745_0	1382359.JIAL01000001_gene350	3.182e-87	304.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50,Peptidase_M50B
HFD2_k127_491745_2	373994.Riv7116_6681	3.194e-13	72.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,1HMK8@1161|Nostocales	1117|Cyanobacteria	H	PFAM Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_4940337_0	278963.ATWD01000001_gene4249	3.457e-108	361.0	COG0308@1|root,COG0308@2|Bacteria,3Y71N@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_4940337_1	1379698.RBG1_1C00001G0272	1.151e-47	177.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
HFD2_k127_4940337_4	1089547.KB913013_gene3993	1.187e-09	71.0	COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,47K73@768503|Cytophagia	976|Bacteroidetes	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292,LolA_like
HFD2_k127_4940337_2	204669.Acid345_1842	3.082e-41	172.0	2C730@1|root,32UQY@2|Bacteria,3Y59Z@57723|Acidobacteria,2JJP2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4963411_0	748449.Halha_0696	3.247e-104	346.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WAH4@53433|Halanaerobiales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
HFD2_k127_4963411_3	1267535.KB906767_gene2420	2.605e-39	153.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_4963411_1	243233.MCA0142	4.401e-103	349.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,1S1GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HFD2_k127_4963411_2	1267534.KB906760_gene1626	9.36e-77	264.0	COG2930@1|root,COG2930@2|Bacteria,3Y4GG@57723|Acidobacteria,2JKH3@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HFD2_k127_4987711_1	234267.Acid_5749	7.632e-28	116.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_4987711_0	204669.Acid345_1052	1.671e-185	602.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HFD2_k127_4997017_0	234267.Acid_3975	4.617e-313	980.0	COG0188@1|root,COG0188@2|Bacteria,3Y2G5@57723|Acidobacteria	57723|Acidobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD2_k127_4997017_3	926566.Terro_3952	3.201e-28	121.0	COG1943@1|root,COG1943@2|Bacteria,3Y84T@57723|Acidobacteria	57723|Acidobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD2_k127_4997017_1	243231.GSU0003	3.813e-280	882.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43U22@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD2_k127_4997017_2	861299.J421_1935	2.421e-97	334.0	COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5002375_0	1382359.JIAL01000001_gene1991	1.827e-100	337.0	COG1109@1|root,COG1109@2|Bacteria,3Y2F7@57723|Acidobacteria,2JHIV@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_5002375_1	204669.Acid345_0570	2.705e-96	327.0	COG0836@1|root,COG0836@2|Bacteria,3Y2W2@57723|Acidobacteria,2JI4D@204432|Acidobacteriia	204432|Acidobacteriia	M	mannose-6-phosphate isomerase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD2_k127_5002375_2	1195236.CTER_3326	1.468e-62	225.0	COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia,3WHTR@541000|Ruminococcaceae	186801|Clostridia	G	TIGRFAM mannose-6-phosphate isomerase, class I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HFD2_k127_5022672_0	234267.Acid_1387	5.617e-302	950.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria	57723|Acidobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1
HFD2_k127_5024571_1	1120973.AQXL01000134_gene1576	3.314e-88	300.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,2784W@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD2_k127_5024571_2	1379698.RBG1_1C00001G0743	2.928e-39	151.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
HFD2_k127_5024571_0	204669.Acid345_4746	1.842e-105	353.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD2_k127_5070095_2	1267535.KB906767_gene4945	1.996e-48	175.0	COG0251@1|root,COG0251@2|Bacteria,3Y5DN@57723|Acidobacteria,2JN2R@204432|Acidobacteriia	204432|Acidobacteriia	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_5070095_1	929703.KE386491_gene2207	4.655e-65	226.0	COG0590@1|root,COG0590@2|Bacteria,4NNMU@976|Bacteroidetes,47PPK@768503|Cytophagia	976|Bacteroidetes	FJ	MafB19-like deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD2_k127_5070095_0	926566.Terro_0850	8.983e-171	544.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5081939_3	290317.Cpha266_0167	1.339e-20	92.0	COG0334@1|root,COG0334@2|Bacteria,1FE0H@1090|Chlorobi	1090|Chlorobi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_5081939_1	1089553.Tph_c17810	6.925e-58	212.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,42F0K@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941,ko:K14153	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HFD2_k127_5081939_4	85643.Tmz1t_1167	2.311e-12	73.0	COG2732@1|root,COG2732@2|Bacteria,1RD25@1224|Proteobacteria,2VWTV@28216|Betaproteobacteria,2M03K@206389|Rhodocyclales	206389|Rhodocyclales	K	Barstar (barnase inhibitor)	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
HFD2_k127_5081939_0	1267535.KB906767_gene1158	5.671e-146	474.0	COG0044@1|root,COG0044@2|Bacteria,3Y34R@57723|Acidobacteria,2JIA3@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_5081939_2	589865.DaAHT2_2315	1.048e-30	124.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,2MIUY@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_5090595_3	682795.AciX8_3840	6.346e-74	256.0	COG0119@1|root,COG0119@2|Bacteria,3Y63Q@57723|Acidobacteria,2JKP2@204432|Acidobacteriia	204432|Acidobacteriia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_5090595_0	204669.Acid345_1428	2.393e-264	825.0	COG4799@1|root,COG4799@2|Bacteria,3Y3DC@57723|Acidobacteria,2JIP2@204432|Acidobacteriia	204432|Acidobacteriia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD2_k127_5090595_4	443143.GM18_2087	1.292e-70	243.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HFD2_k127_5090595_1	273075.Ta0351	3.389e-185	597.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_5090595_2	1382359.JIAL01000001_gene1745	1.555e-94	317.0	COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria,2JITC@204432|Acidobacteriia	204432|Acidobacteriia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_5094049_4	204669.Acid345_3614	4.715e-16	78.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria,2JI7W@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD2_k127_5094049_1	234267.Acid_0789	4.001e-55	211.0	COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria	57723|Acidobacteria	C	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_5094049_3	1340493.JNIF01000003_gene1690	3.558e-26	116.0	2DMGW@1|root,32REM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
HFD2_k127_5094049_5	1267535.KB906767_gene1042	3.987e-14	80.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_5094049_0	1267535.KB906767_gene1043	2.25e-63	223.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria,2JJAJ@204432|Acidobacteriia	204432|Acidobacteriia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5094049_2	234267.Acid_0794	1.536e-33	145.0	COG0392@1|root,COG0392@2|Bacteria,3Y3SG@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD2_k127_5111428_0	472759.Nhal_2900	0.0	1274.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_5159375_1	1430440.MGMSRv2_3391	3.407e-11	70.0	COG0438@1|root,COG0438@2|Bacteria,1NK9S@1224|Proteobacteria,2UKVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD2_k127_5159375_0	1166018.FAES_1589	3.287e-124	422.0	COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,47JSF@768503|Cytophagia	976|Bacteroidetes	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_5168845_4	204669.Acid345_3921	3.993e-100	334.0	COG0146@1|root,COG0146@2|Bacteria,3Y6W2@57723|Acidobacteria,2JKCE@204432|Acidobacteriia	204432|Acidobacteriia	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD2_k127_5168845_0	479434.Sthe_2481	6.819e-194	631.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD2_k127_5168845_7	234267.Acid_4536	4.773e-27	116.0	COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_5168845_2	1267534.KB906760_gene1487	1.033e-114	381.0	COG0533@1|root,COG0533@2|Bacteria,3Y2PN@57723|Acidobacteria,2JHJ0@204432|Acidobacteriia	204432|Acidobacteriia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_5168845_3	1340493.JNIF01000003_gene3319	1.112e-112	374.0	COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_5168845_8	1267533.KB906741_gene538	5.427e-22	98.0	COG2331@1|root,COG2331@2|Bacteria,3Y5KN@57723|Acidobacteria,2JJW0@204432|Acidobacteriia	204432|Acidobacteriia	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD2_k127_5168845_5	204669.Acid345_0035	2.368e-90	307.0	COG0313@1|root,COG0313@2|Bacteria,3Y32N@57723|Acidobacteria,2JIGR@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD2_k127_5168845_1	234267.Acid_6679	7.111e-128	416.0	COG0042@1|root,COG0042@2|Bacteria,3Y3XE@57723|Acidobacteria	57723|Acidobacteria	J	synthase	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HFD2_k127_5168845_9	234267.Acid_7418	6.66e-20	99.0	COG3682@1|root,COG3682@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD2_k127_5168845_6	1267535.KB906767_gene1574	3.6e-62	219.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria,2JITD@204432|Acidobacteriia	204432|Acidobacteriia	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HFD2_k127_5187704_0	1382359.JIAL01000001_gene2034	7.817e-115	394.0	COG1196@1|root,COG1196@2|Bacteria,3Y2W1@57723|Acidobacteria,2JHJF@204432|Acidobacteriia	204432|Acidobacteriia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD2_k127_518876_11	247156.NFA_12060	6.769e-18	85.0	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,4FYW4@85025|Nocardiaceae	201174|Actinobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_518876_4	370438.PTH_1397	4.195e-48	183.0	COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,24BI5@186801|Clostridia,260JN@186807|Peptococcaceae	186801|Clostridia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD2_k127_518876_6	1379698.RBG1_1C00001G0055	1.191e-42	171.0	COG0671@1|root,COG0671@2|Bacteria,2NRVZ@2323|unclassified Bacteria	2|Bacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_518876_10	32057.KB217482_gene8781	6.104e-21	103.0	COG0560@1|root,COG0560@2|Bacteria,1GAKQ@1117|Cyanobacteria	1117|Cyanobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,LPG_synthase_TM
HFD2_k127_518876_8	1382356.JQMP01000004_gene264	1.224e-32	135.0	COG0558@1|root,COG0558@2|Bacteria,2G7HQ@200795|Chloroflexi,27YAM@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_518876_2	204669.Acid345_0180	5.28e-63	226.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	ccdA	-	1.8.4.11,1.8.4.12	ko:K06196,ko:K12267	-	-	-	-	ko00000,ko01000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
HFD2_k127_518876_7	1267535.KB906767_gene4961	8.296e-37	146.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria	57723|Acidobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HFD2_k127_518876_3	1382359.JIAL01000001_gene1762	4.372e-50	191.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,YjbH
HFD2_k127_518876_5	526227.Mesil_0424	3.567e-46	181.0	COG0412@1|root,COG0412@2|Bacteria,1WM88@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_518876_1	234267.Acid_3806	1.629e-106	359.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_518876_0	204669.Acid345_4376	8.76e-148	478.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria,2JMFF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_518876_12	1340493.JNIF01000003_gene4260	5.273e-17	89.0	COG4233@1|root,COG4233@2|Bacteria	2|Bacteria	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084,ko:K06888	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HFD2_k127_518876_9	204669.Acid345_0184	5.299e-29	119.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria,2JHZW@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD2_k127_5199180_2	234267.Acid_0469	1.097e-77	268.0	COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria	57723|Acidobacteria	E	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HFD2_k127_5199180_5	745411.B3C1_01255	1.392e-28	128.0	COG0705@1|root,COG3809@1|root,COG0705@2|Bacteria,COG3809@2|Bacteria,1MYFP@1224|Proteobacteria,1SWT5@1236|Gammaproteobacteria,1J6XT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_5199180_3	234267.Acid_1280	2.063e-53	199.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_5199180_1	867903.ThesuDRAFT_00094	2.242e-90	309.0	COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,24ETR@186801|Clostridia	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_5199180_0	234267.Acid_1387	8.701e-128	415.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria	57723|Acidobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1
HFD2_k127_5224333_2	639030.JHVA01000001_gene2643	4.397e-44	166.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria,2JKRD@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD2_k127_5224333_3	1379698.RBG1_1C00001G0621	1.434e-39	152.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,HTH_18,Rhodanese
HFD2_k127_5224333_0	1163617.SCD_n02012	1.738e-108	364.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5224333_1	234267.Acid_6893	5.093e-62	219.0	COG1388@1|root,COG1388@2|Bacteria,3Y4VG@57723|Acidobacteria	57723|Acidobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD2_k127_5226179_5	234267.Acid_0082	1.897e-17	86.0	2FE51@1|root,3464Y@2|Bacteria,3Y8E0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5226179_1	1340493.JNIF01000003_gene2543	7.381e-95	318.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_5226179_4	1049564.TevJSym_aa00380	1.696e-23	107.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,1S5YT@1236|Gammaproteobacteria,1J66R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_5226179_3	1408473.JHXO01000007_gene928	1.255e-27	122.0	COG4122@1|root,COG4122@2|Bacteria,4NNYP@976|Bacteroidetes	976|Bacteroidetes	M	tRNA methyltransferase complex GCD14 subunit	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HFD2_k127_5226179_0	1267533.KB906733_gene2862	1.377e-126	432.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,3Y4B2@57723|Acidobacteria,2JJ4V@204432|Acidobacteriia	204432|Acidobacteriia	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
HFD2_k127_5226179_2	745310.G432_03775	4.518e-82	280.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2K117@204457|Sphingomonadales	204457|Sphingomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_5255865_9	240015.ACP_1918	0.0002845	49.0	29QWH@1|root,30BWY@2|Bacteria,3Y4SG@57723|Acidobacteria,2JJDK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5255865_2	204669.Acid345_1153	6.487e-164	537.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HFD2_k127_5255865_7	634956.Geoth_3039	8.864e-39	154.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1WFBZ@129337|Geobacillus	91061|Bacilli	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD2_k127_5255865_0	1382359.JIAL01000001_gene479	2.098e-280	888.0	COG0013@1|root,COG0013@2|Bacteria,3Y359@57723|Acidobacteria,2JIIR@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD2_k127_5255865_4	1379698.RBG1_1C00001G1799	8.442e-84	286.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HFD2_k127_5255865_8	240015.ACP_1786	2.356e-16	85.0	COG2137@1|root,COG2137@2|Bacteria,3Y4WT@57723|Acidobacteria,2JJMB@204432|Acidobacteriia	204432|Acidobacteriia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HFD2_k127_5255865_1	204669.Acid345_0704	3.991e-189	598.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD2_k127_5255865_6	264201.pc0796	5.629e-61	219.0	COG0580@1|root,COG0580@2|Bacteria,2JGJ6@204428|Chlamydiae	204428|Chlamydiae	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	-	-	-	-	-	-	-	-	-	MIP
HFD2_k127_5255865_3	861299.J421_1738	3.401e-124	409.0	COG0665@1|root,COG0665@2|Bacteria,1ZSZG@142182|Gemmatimonadetes	2|Bacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_5255865_5	1047013.AQSP01000134_gene1353	2.978e-65	233.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_5281663_1	502025.Hoch_4147	3.603e-115	386.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD2_k127_5281663_0	1267535.KB906767_gene2333	3.152e-190	633.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,3Y5KB@57723|Acidobacteria,2JHVK@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
HFD2_k127_5281663_2	1242864.D187_003284	5.182e-47	177.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	XK27_02315	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_5281663_3	1340493.JNIF01000003_gene1338	2.362e-43	162.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_5298806_1	204669.Acid345_2948	3.991e-106	349.0	COG1180@1|root,COG1180@2|Bacteria,3Y62D@57723|Acidobacteria	57723|Acidobacteria	O	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HFD2_k127_5298806_6	497964.CfE428DRAFT_4835	4.009e-15	80.0	COG4747@1|root,COG4747@2|Bacteria,46WIS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HFD2_k127_5298806_5	913865.DOT_4615	1.591e-26	121.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HFD2_k127_5298806_4	595460.RRSWK_04730	2.28e-29	123.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_5298806_7	251229.Chro_2900	2.301e-11	69.0	2F8VD@1|root,3417B@2|Bacteria,1GEHW@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5298806_3	84531.JMTZ01000002_gene798	1.57e-30	124.0	2C3PV@1|root,3307H@2|Bacteria,1N0Y3@1224|Proteobacteria,1SDDG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
HFD2_k127_5298806_0	204669.Acid345_1757	2.747e-244	776.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD2_k127_5298806_2	204669.Acid345_2082	5.546e-54	194.0	COG1968@1|root,COG1968@2|Bacteria,3Y2N3@57723|Acidobacteria,2JI1A@204432|Acidobacteriia	204432|Acidobacteriia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD2_k127_5299631_1	1267535.KB906767_gene2508	3.112e-43	169.0	COG1597@1|root,COG1597@2|Bacteria,3Y58A@57723|Acidobacteria,2JP23@204432|Acidobacteriia	204432|Acidobacteriia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD2_k127_5299631_0	204669.Acid345_4656	2.095e-90	304.0	COG0272@1|root,COG0272@2|Bacteria,3Y2UR@57723|Acidobacteria,2JHN1@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD2_k127_532640_2	909663.KI867150_gene859	2.524e-29	132.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria,2MREP@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_532640_0	1121405.dsmv_2388	3.455e-86	292.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_532640_1	1380356.JNIK01000014_gene3301	6.573e-63	230.0	COG3396@1|root,COG3396@2|Bacteria,2GK2T@201174|Actinobacteria,4EUK6@85013|Frankiales	201174|Actinobacteria	S	Phenylacetate-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD2_k127_532640_3	457415.HMPREF1006_01234	2.783e-09	60.0	COG1024@1|root,COG1024@2|Bacteria,3TBDD@508458|Synergistetes	508458|Synergistetes	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_5359337_1	1267535.KB906767_gene5343	1.86e-52	195.0	2F7K7@1|root,3400T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5359337_3	880072.Desac_2179	0.0002251	51.0	COG0468@1|root,COG0468@2|Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	AAA_12,AAA_24,AAA_25,DUF4011
HFD2_k127_5359337_2	880072.Desac_2172	1.056e-08	61.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5359337_0	880072.Desac_2171	5.297e-55	209.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HFD2_k127_5382371_1	710111.FraQA3DRAFT_4770	1.076e-201	637.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD2_k127_5382371_3	234267.Acid_7923	4.109e-162	522.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_5382371_0	234267.Acid_6523	9.721e-283	883.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y6FN@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_5382371_2	251221.35210936	4.046e-178	587.0	COG1574@1|root,COG1574@2|Bacteria,1G40U@1117|Cyanobacteria	1117|Cyanobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_5391053_0	234267.Acid_7185	4.297e-172	567.0	COG3386@1|root,COG3386@2|Bacteria,3Y2G7@57723|Acidobacteria	57723|Acidobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5391053_4	1232410.KI421412_gene154	6.841e-05	50.0	292XF@1|root,2ZQEX@2|Bacteria,1P8W2@1224|Proteobacteria,432F4@68525|delta/epsilon subdivisions,2WXUJ@28221|Deltaproteobacteria,43VN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HFD2_k127_5391053_1	448385.sce3847	1.339e-110	368.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_5391053_3	234267.Acid_6108	8.415e-28	122.0	COG4798@1|root,COG4798@2|Bacteria	2|Bacteria	E	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT
HFD2_k127_5391053_2	357808.RoseRS_2143	5.334e-68	245.0	COG0491@1|root,COG0491@2|Bacteria,2G6KC@200795|Chloroflexi,376B0@32061|Chloroflexia	32061|Chloroflexia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5391077_7	204669.Acid345_2618	6.345e-52	193.0	COG0204@1|root,COG0204@2|Bacteria,3Y49D@57723|Acidobacteria,2JJ6K@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_5391077_4	204669.Acid345_2619	4.1e-104	363.0	COG3975@1|root,COG3975@2|Bacteria,3Y411@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase M61	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HFD2_k127_5391077_1	204669.Acid345_2620	2.044e-147	482.0	COG0773@1|root,COG0773@2|Bacteria,3Y2M2@57723|Acidobacteria,2JIE2@204432|Acidobacteriia	204432|Acidobacteriia	M	Mur ligase middle domain	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_5391077_9	204669.Acid345_2621	1.284e-47	184.0	COG1619@1|root,COG1619@2|Bacteria,3Y3SS@57723|Acidobacteria,2JHRY@204432|Acidobacteriia	204432|Acidobacteriia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HFD2_k127_5391077_6	370438.PTH_1800	6.025e-62	223.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD2_k127_5391077_10	204669.Acid345_2623	8.588e-47	177.0	COG1285@1|root,COG1285@2|Bacteria,3Y4TX@57723|Acidobacteria,2JJM0@204432|Acidobacteriia	204432|Acidobacteriia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HFD2_k127_5391077_5	234267.Acid_4601	1.476e-103	344.0	COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD2_k127_5391077_2	204669.Acid345_2626	5.354e-120	392.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_5391077_3	204669.Acid345_2365	5.105e-114	376.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD2_k127_5391077_0	204669.Acid345_2369	2.635e-176	563.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5391077_8	204669.Acid345_2367	7.498e-51	184.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD2_k127_5401457_0	234267.Acid_0085	2.823e-161	515.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HFD2_k127_5401457_2	234267.Acid_0084	1.053e-82	291.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5401457_1	234267.Acid_0083	1.11e-88	305.0	COG1502@1|root,COG1502@2|Bacteria,3Y5UA@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD2_k127_5420864_0	1122962.AULH01000001_gene1570	1.666e-143	477.0	COG0167@1|root,COG0479@1|root,COG0167@2|Bacteria,COG0479@2|Bacteria,1PHK0@1224|Proteobacteria,2UQYP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CF	dihydroorotate dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5420864_1	502025.Hoch_4147	5.577e-55	196.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD2_k127_5422622_0	1267535.KB906767_gene4172	7.464e-141	458.0	COG1966@1|root,COG1966@2|Bacteria,3Y436@57723|Acidobacteria,2JKKA@204432|Acidobacteriia	204432|Acidobacteriia	T	Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HFD2_k127_5422622_1	1332071.L581_0851	1.168e-19	98.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria,3ZZMH@613|Serratia	1236|Gammaproteobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
HFD2_k127_5450675_2	240015.ACP_0160	1.042e-155	510.0	COG1956@1|root,COG2203@1|root,COG2208@1|root,COG1956@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
HFD2_k127_5450675_7	234267.Acid_2205	2.215e-78	275.0	COG0274@1|root,COG0274@2|Bacteria,3Y2Q4@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_5450675_10	234267.Acid_2204	1.134e-48	181.0	COG0698@1|root,COG0698@2|Bacteria	2|Bacteria	G	galactose-6-phosphate isomerase activity	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
HFD2_k127_5450675_9	1267533.KB906736_gene852	1.756e-59	214.0	COG0634@1|root,COG0634@2|Bacteria,3Y7PS@57723|Acidobacteria,2JMQY@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HFD2_k127_5450675_5	234267.Acid_6465	6.174e-100	364.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HFD2_k127_5450675_4	189753.AXAS01000013_gene5867	9.734e-115	378.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,3JSJF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HFD2_k127_5450675_0	204669.Acid345_0770	2.222e-273	859.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
HFD2_k127_5450675_1	1210884.HG799465_gene11400	2.094e-244	769.0	COG2936@1|root,COG2936@2|Bacteria,2IY51@203682|Planctomycetes	2|Bacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD2_k127_5450675_15	593117.TGAM_2115	2.527e-08	63.0	arCOG10043@1|root,arCOG10043@2157|Archaea	593117.TGAM_2115|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5450675_14	204669.Acid345_0600	6.423e-13	74.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Ribosomal_S30AE,Sigma70_r2,Sigma70_r4_2
HFD2_k127_5450675_6	1267535.KB906767_gene1253	2.01e-88	302.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_5450675_13	357808.RoseRS_4228	1.283e-27	128.0	COG2244@1|root,COG2244@2|Bacteria,2G8GU@200795|Chloroflexi,3767K@32061|Chloroflexia	32061|Chloroflexia	S	virulence factor MVIN family protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HFD2_k127_5450675_3	204669.Acid345_1747	1.092e-130	432.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,3Y3PB@57723|Acidobacteria,2JIW6@204432|Acidobacteriia	204432|Acidobacteriia	C	FAD dependent oxidoreductase	-	-	1.3.5.6	ko:K00514	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_5450675_8	1267535.KB906767_gene2365	1.015e-77	271.0	COG1562@1|root,COG1562@2|Bacteria,3Y3YX@57723|Acidobacteria,2JIHF@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_5450675_11	204669.Acid345_1745	3.325e-36	142.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria,2JIMK@204432|Acidobacteriia	204432|Acidobacteriia	I	Squalene/phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HFD2_k127_5451457_4	765420.OSCT_1180	4.886e-06	48.0	COG2040@1|root,COG2040@2|Bacteria	2|Bacteria	E	homocysteine	mmuM	GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HFD2_k127_5451457_1	861299.J421_4351	4.146e-118	394.0	COG0833@1|root,COG0833@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294,ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.2,2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HFD2_k127_5451457_0	1382359.JIAL01000001_gene723	7.34e-206	653.0	COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia	204432|Acidobacteriia	C	Delta-1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD2_k127_5451457_3	1184609.KILIM_069_00290	1.114e-06	55.0	COG1366@1|root,COG1366@2|Bacteria,2HPDK@201174|Actinobacteria,4F787@85018|Dermatophilaceae	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
HFD2_k127_5451457_2	204669.Acid345_1271	7.569e-80	270.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HFD2_k127_549042_1	1382359.JIAL01000001_gene1618	5.654e-47	171.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_549042_3	926550.CLDAP_20590	1.168e-14	78.0	COG5660@1|root,COG5660@2|Bacteria,2G7CH@200795|Chloroflexi	200795|Chloroflexi	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_549042_2	240015.ACP_0219	1.418e-22	112.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_549042_0	1267533.KB906734_gene4274	4.371e-170	546.0	2DBJC@1|root,2Z9K5@2|Bacteria	2|Bacteria	S	Glycosyl hydrolase family 47	-	-	3.2.1.113	ko:K01230,ko:K10085	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00073,M00074	R05982,R06722	-	ko00000,ko00001,ko00002,ko01000,ko04091,ko04131	-	GH47	-	Glyco_hydro_47
HFD2_k127_550441_0	1267535.KB906767_gene2115	1.817e-224	705.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria,2JHY9@204432|Acidobacteriia	204432|Acidobacteriia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD2_k127_550441_1	443144.GM21_1665	9.614e-62	222.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,42ZKN@68525|delta/epsilon subdivisions,2WUTQ@28221|Deltaproteobacteria,43VG8@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_5508750_0	880072.Desac_2282	8.23e-164	534.0	COG1752@1|root,COG1752@2|Bacteria,1PGY0@1224|Proteobacteria,42MKJ@68525|delta/epsilon subdivisions,2WK4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_5508750_2	161528.ED21_23741	8.394e-97	334.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales	204457|Sphingomonadales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Pyr_redox_3
HFD2_k127_5508750_4	204669.Acid345_0468	1.339e-81	283.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding
HFD2_k127_5508750_3	204669.Acid345_0471	8.822e-84	281.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5517637_0	861299.J421_5960	1.273e-136	460.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5525538_3	234267.Acid_6354	5.849e-20	93.0	COG0809@1|root,COG0809@2|Bacteria,3Y336@57723|Acidobacteria	57723|Acidobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_5525538_1	290397.Adeh_3722	2.358e-120	398.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HFD2_k127_5525538_2	671143.DAMO_2768	3.541e-42	159.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_5525538_0	204669.Acid345_4765	1.011e-166	533.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria,2JIAE@204432|Acidobacteriia	204432|Acidobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_5533359_2	224324.aq_323	4.854e-45	169.0	COG0667@1|root,COG0667@2|Bacteria,2G4NK@200783|Aquificae	200783|Aquificae	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_5533359_0	1250232.JQNJ01000001_gene3441	1.225e-88	310.0	COG3975@1|root,COG3975@2|Bacteria,4P0G5@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5533359_1	240015.ACP_0264	7.717e-66	231.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD2_k127_5564171_0	1267534.KB906759_gene1947	1.989e-145	471.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5564171_1	926566.Terro_0849	1.542e-60	213.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_5564171_2	926566.Terro_0848	5.062e-47	174.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_5564489_9	1394178.AWOO02000011_gene4014	3.967e-12	73.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_5564489_7	234267.Acid_5255	6.036e-61	222.0	2B11W@1|root,31TFA@2|Bacteria,3Y4Z8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5564489_4	215803.DB30_4655	3.496e-159	531.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	1224|Proteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5564489_1	251221.35211765	3.046e-187	613.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_5564489_8	1267533.KB906741_gene568	6.774e-36	141.0	2E4M2@1|root,32ZG2@2|Bacteria,3Y5MC@57723|Acidobacteria,2JNHX@204432|Acidobacteriia	204432|Acidobacteriia	S	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase
HFD2_k127_5564489_3	251221.35211765	1.018e-166	552.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_5564489_5	234267.Acid_3798	6.722e-155	519.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_3798|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5564489_0	1267535.KB906767_gene618	8.17e-272	861.0	COG0577@1|root,COG0577@2|Bacteria,3Y38T@57723|Acidobacteria,2JKAN@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5564489_2	1267535.KB906767_gene3131	6.029e-181	600.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia	204432|Acidobacteriia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5564489_6	234267.Acid_1737	5.381e-79	281.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_5569219_3	1382359.JIAL01000001_gene595	1.804e-43	161.0	COG0292@1|root,COG0292@2|Bacteria,3Y4SW@57723|Acidobacteria,2JJJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HFD2_k127_5569219_1	880073.Calab_3704	3.455e-103	347.0	COG0016@1|root,COG0016@2|Bacteria,2NNNT@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415,iJN746.PP_2469,iSSON_1240.SSON_1444,iYL1228.KPN_02176	Phe_tRNA-synt_N,tRNA-synt_2d
HFD2_k127_5569219_2	1541065.JRFE01000057_gene6298	2.521e-62	220.0	COG0500@1|root,COG2226@2|Bacteria,1G0GS@1117|Cyanobacteria,3VIJE@52604|Pleurocapsales	1117|Cyanobacteria	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_5569219_0	204669.Acid345_0718	2.51e-155	515.0	COG0072@1|root,COG0072@2|Bacteria,3Y353@57723|Acidobacteria,2JIM2@204432|Acidobacteriia	204432|Acidobacteriia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB
HFD2_k127_5569538_1	1267535.KB906767_gene2167	6.194e-57	204.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria,2JN23@204432|Acidobacteriia	204432|Acidobacteriia	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HFD2_k127_5569538_0	1340493.JNIF01000003_gene2232	7.553e-192	618.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5574966_3	204669.Acid345_2264	4.198e-19	89.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria,2JK01@204432|Acidobacteriia	204432|Acidobacteriia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
HFD2_k127_5574966_4	204669.Acid345_2265	3.289e-14	79.0	2EFJQ@1|root,339C1@2|Bacteria,3Y5HX@57723|Acidobacteria,2JK17@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5574966_2	1121374.KB891592_gene2960	2.289e-28	123.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein conserved in bacteria	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HFD2_k127_5574966_0	234267.Acid_0599	1.605e-141	459.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD2_k127_5574966_1	246194.CHY_2199	1.265e-130	426.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_5590361_4	589924.Ferp_2066	2.871e-14	76.0	COG5557@1|root,arCOG02025@2157|Archaea,2Y4BF@28890|Euryarchaeota,2477G@183980|Archaeoglobi	183980|Archaeoglobi	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD2_k127_5590361_1	1168034.FH5T_09780	2.059e-72	255.0	COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes,2FWWQ@200643|Bacteroidia	976|Bacteroidetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
HFD2_k127_5590361_5	1196323.ALKF01000192_gene3230	7.08e-08	60.0	COG4263@1|root,COG4263@2|Bacteria,1UJF1@1239|Firmicutes,4IT7I@91061|Bacilli,2779A@186822|Paenibacillaceae	91061|Bacilli	C	nitrous-oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5590361_6	1296415.JACC01000006_gene1510	0.0008573	46.0	COG3245@1|root,COG3245@2|Bacteria,4PJ3G@976|Bacteroidetes,1IMG7@117743|Flavobacteriia,2YKV3@290174|Aquimarina	976|Bacteroidetes	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5590361_2	639030.JHVA01000001_gene471	7.793e-59	216.0	2EZ7I@1|root,33SDE@2|Bacteria,3Y4F4@57723|Acidobacteria,2JJ3D@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5590361_0	316067.Geob_1633	3.765e-98	338.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WIKI@28221|Deltaproteobacteria,43VZC@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_5590361_3	1121396.KB893116_gene3141	1.007e-41	170.0	COG4191@1|root,COG4191@2|Bacteria,1MY12@1224|Proteobacteria,42PID@68525|delta/epsilon subdivisions,2WJVW@28221|Deltaproteobacteria,2MI1P@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
HFD2_k127_5598227_4	234267.Acid_2697	4.456e-35	143.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD2_k127_5598227_5	234267.Acid_4522	7.707e-25	111.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	mauE	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
HFD2_k127_5598227_1	204669.Acid345_0503	2.362e-81	275.0	COG2191@1|root,COG2191@2|Bacteria,3Y43J@57723|Acidobacteria,2JHT2@204432|Acidobacteriia	204432|Acidobacteriia	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
HFD2_k127_5598227_0	204669.Acid345_4231	3.497e-249	791.0	COG5009@1|root,COG5009@2|Bacteria,3Y31C@57723|Acidobacteria,2JHJY@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD2_k127_5598227_3	204669.Acid345_4694	6.735e-64	232.0	COG0611@1|root,COG0611@2|Bacteria,3Y30U@57723|Acidobacteria,2JHT0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_5598227_2	1382359.JIAL01000001_gene1062	1.884e-70	250.0	COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria,2JHPR@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD2_k127_5598227_6	1267535.KB906767_gene703	9.605e-07	60.0	28MK6@1|root,33VBX@2|Bacteria,3Y7JM@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5598227_7	1461580.CCAS010000015_gene1842	0.00014	47.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5602076_2	1210884.HG799474_gene15144	2.821e-33	134.0	COG0251@1|root,COG0251@2|Bacteria,2J1GN@203682|Planctomycetes	203682|Planctomycetes	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_5602076_6	35754.JNYJ01000010_gene1612	0.0003713	50.0	2DNR3@1|root,32YQ5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_5602076_1	204669.Acid345_4703	1.092e-52	191.0	COG2318@1|root,COG2318@2|Bacteria,3Y4AI@57723|Acidobacteria,2JKRK@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
HFD2_k127_5602076_4	290512.Paes_1514	4.175e-10	64.0	2ERSA@1|root,33JBH@2|Bacteria,1FEBR@1090|Chlorobi	1090|Chlorobi	S	Cysteine-rich CWC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CWC
HFD2_k127_5602076_3	1116472.MGMO_126c00180	8.444e-17	86.0	COG4244@1|root,COG4244@2|Bacteria,1NPG4@1224|Proteobacteria,1SZU6@1236|Gammaproteobacteria,1XH0G@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD2_k127_5602076_0	1124780.ANNU01000071_gene1026	1.775e-163	529.0	COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,47KI1@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
HFD2_k127_5610649_5	1444711.CCJF01000005_gene546	1.031e-110	377.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
HFD2_k127_5610649_3	234267.Acid_0998	1.085e-187	595.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K08196	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
HFD2_k127_5610649_9	1479239.JQMU01000001_gene1555	2.893e-37	145.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2U3TF@28211|Alphaproteobacteria,2K5IS@204457|Sphingomonadales	204457|Sphingomonadales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HFD2_k127_5610649_0	204669.Acid345_0515	0.0	1334.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_5610649_1	1340493.JNIF01000004_gene270	9.034e-313	990.0	COG0841@1|root,COG0841@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_5610649_7	671143.DAMO_1260	1.026e-64	237.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_5610649_6	1267533.KB906737_gene2024	2.494e-107	357.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_5610649_8	1267533.KB906741_gene406	1.203e-58	211.0	2B4PH@1|root,31XFS@2|Bacteria,3Y8X7@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HFD2_k127_5610649_2	1519464.HY22_03915	2.77e-306	952.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
HFD2_k127_5610649_4	552811.Dehly_0457	1.057e-148	481.0	COG0001@1|root,COG0001@2|Bacteria	2|Bacteria	H	glutamate-1-semialdehyde 2,1-aminomutase activity	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158	Aminotran_3
HFD2_k127_561168_3	1340493.JNIF01000004_gene675	8.119e-47	171.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MB@57723|Acidobacteria	57723|Acidobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_561168_2	234267.Acid_5234	4.882e-48	179.0	COG0295@1|root,COG0295@2|Bacteria,3Y5GE@57723|Acidobacteria	57723|Acidobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD2_k127_561168_0	234267.Acid_5235	5.49e-163	526.0	COG0402@1|root,COG0402@2|Bacteria,3Y64N@57723|Acidobacteria	57723|Acidobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_561168_4	639282.DEFDS_1088	6.1e-22	107.0	2DMMW@1|root,32SIJ@2|Bacteria,2GFD5@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_561168_5	1449126.JQKL01000001_gene1400	2.049e-16	88.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
HFD2_k127_561168_1	204669.Acid345_3659	6.909e-131	428.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,3Y40V@57723|Acidobacteria,2JI0P@204432|Acidobacteriia	204432|Acidobacteriia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
HFD2_k127_5658280_0	246969.TAM4_535	4.562e-28	134.0	COG1874@1|root,arCOG05856@2157|Archaea,2Y2E1@28890|Euryarchaeota,243W7@183968|Thermococci	183968|Thermococci	G	Beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42
HFD2_k127_5658280_1	29495.EA26_07665	1.969e-10	66.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1XYDK@135623|Vibrionales	135623|Vibrionales	C	COG1254 Acylphosphatases	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HFD2_k127_5672382_3	278963.ATWD01000002_gene307	6.174e-24	104.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HFD2_k127_5672382_1	255470.cbdbA32	9.338e-49	189.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,34CKI@301297|Dehalococcoidia	301297|Dehalococcoidia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_5672382_4	521460.Athe_0243	1.011e-19	102.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,42H6T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	trkA2	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
HFD2_k127_5672382_0	234267.Acid_1288	2.252e-155	504.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD2_k127_5672382_2	477974.Daud_0256	1.237e-45	172.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,261PA@186807|Peptococcaceae	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HFD2_k127_5672382_5	1267534.KB906756_gene158	2.63e-06	54.0	COG4796@1|root,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria,2JHZH@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N
HFD2_k127_5689881_8	234267.Acid_5454	1.493e-17	84.0	COG0511@1|root,COG1413@1|root,COG0511@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	pcmV	-	2.3.1.12	ko:K00627,ko:K02160,ko:K07402	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,MDMPI_C,MDMPI_N,XdhC_C,XdhC_CoxI
HFD2_k127_5689881_3	234267.Acid_3885	2.641e-47	173.0	COG1245@1|root,COG1245@2|Bacteria	2|Bacteria	C	4Fe-4S binding domain	rnfB	-	1.8.99.2	ko:K00395,ko:K02572,ko:K03616	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FeS,Fer4,Fer4_4,Fer4_7
HFD2_k127_5689881_9	1408473.JHXO01000009_gene3379	1.903e-12	76.0	2BXUX@1|root,32R23@2|Bacteria,4NR4Y@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5689881_1	1278073.MYSTI_06958	2.68e-117	384.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,43B0A@68525|delta/epsilon subdivisions,2X6EE@28221|Deltaproteobacteria,2YUMP@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	leuB2	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_5689881_10	696281.Desru_1310	0.0005401	43.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260YV@186807|Peptococcaceae	186801|Clostridia	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73	ko:K00030,ko:K07246	ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00215,R00709,R01751,R02545,R06180	RC00084,RC00105,RC00114,RC00594	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_5689881_5	234267.Acid_4200	1.58e-44	164.0	COG0316@1|root,COG0316@2|Bacteria,3Y4ZB@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD2_k127_5689881_7	247490.KSU1_B0487	3.146e-35	142.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TehB
HFD2_k127_5689881_2	330214.NIDE1061	3.204e-51	187.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_5689881_4	1267535.KB906767_gene940	2.872e-47	174.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria,2JHPJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD2_k127_5689881_0	204669.Acid345_2524	2.739e-143	464.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria,2JHPJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD2_k127_5689881_6	234267.Acid_1454	8.248e-41	162.0	COG1651@1|root,COG1651@2|Bacteria,3Y2G9@57723|Acidobacteria	57723|Acidobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DsbC_N,Thioredoxin_4
HFD2_k127_5719082_5	886293.Sinac_2608	1.224e-87	301.0	COG0075@1|root,COG0075@2|Bacteria,2IYEK@203682|Planctomycetes	203682|Planctomycetes	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD2_k127_5719082_0	144197.XP_008287530.1	1.337e-198	638.0	COG0021@1|root,KOG0523@2759|Eukaryota,38B8B@33154|Opisthokonta,3BG4D@33208|Metazoa,3CXK5@33213|Bilateria,484SM@7711|Chordata,48VMD@7742|Vertebrata,49W26@7898|Actinopterygii	33208|Metazoa	G	Transketolase b	TKTL2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031935,GO:0033043,GO:0033044,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0060968,GO:0065007,GO:0080090,GO:1902275,GO:1903506,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_5719082_3	246197.MXAN_6306	9.831e-114	373.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,42YFC@68525|delta/epsilon subdivisions,2WU03@28221|Deltaproteobacteria,2YUBP@29|Myxococcales	28221|Deltaproteobacteria	I	desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_5719082_4	234267.Acid_0053	3.354e-95	336.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria	57723|Acidobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_5719082_6	204669.Acid345_1460	2.903e-74	265.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FecR,LysM,fn3
HFD2_k127_5719082_1	1382359.JIAL01000001_gene760	1.57e-190	599.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria,2JHQ2@204432|Acidobacteriia	204432|Acidobacteriia	D	cell shape determining protein MreB	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD2_k127_5719082_7	926566.Terro_3276	6.252e-51	192.0	COG1792@1|root,COG1792@2|Bacteria,3Y3CK@57723|Acidobacteria,2JIBI@204432|Acidobacteriia	204432|Acidobacteriia	M	Rod shape-determining protein MreC	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD2_k127_5719082_8	204669.Acid345_1463	3.219e-35	141.0	2CM1I@1|root,32SDF@2|Bacteria,3Y571@57723|Acidobacteria,2JJRW@204432|Acidobacteriia	204432|Acidobacteriia	S	shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD2_k127_5719082_2	644282.Deba_0280	5.272e-123	415.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
HFD2_k127_5747436_2	546271.Selsp_0551	6.154e-14	80.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4H4P3@909932|Negativicutes	909932|Negativicutes	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HFD2_k127_5747436_3	204669.Acid345_2361	2.829e-06	53.0	2ETRB@1|root,33M8W@2|Bacteria,3Y5ZS@57723|Acidobacteria,2JNW9@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HFD2_k127_5747436_1	1131269.AQVV01000018_gene1893	1.577e-48	181.0	COG0688@1|root,COG0688@2|Bacteria	2|Bacteria	I	phosphatidylethanolamine metabolic process	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD2_k127_5747436_0	682795.AciX8_3305	5.397e-52	199.0	COG1183@1|root,COG1183@2|Bacteria,3Y3I7@57723|Acidobacteria,2JIEG@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_5750744_0	204669.Acid345_2697	1.494e-96	321.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria,2JHTC@204432|Acidobacteriia	204432|Acidobacteriia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD2_k127_5750744_2	246197.MXAN_1542	1.031e-06	59.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	rpcE	-	4.4.1.32	ko:K02288	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	-	HEAT_2,HEAT_PBS,LRV,Thioredoxin_3
HFD2_k127_5750744_1	1157490.EL26_09635	7.36e-53	192.0	COG2377@1|root,COG2377@2|Bacteria,1TSBU@1239|Firmicutes,4HAYA@91061|Bacilli	91061|Bacilli	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
HFD2_k127_5760683_0	383372.Rcas_3080	1.393e-235	734.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_5760683_1	1121920.AUAU01000004_gene645	7.9e-125	404.0	COG0479@1|root,COG0479@2|Bacteria,3Y3XR@57723|Acidobacteria	57723|Acidobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HFD2_k127_5760683_2	1267534.KB906759_gene1880	1.616e-105	357.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD2_k127_5760683_3	1297742.A176_01664	9.204e-79	273.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YW82@29|Myxococcales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD2_k127_5762913_8	682795.AciX8_0163	5.989e-39	147.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_5762913_1	204669.Acid345_0722	1.207e-126	419.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria,2JI94@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_5762913_7	489825.LYNGBM3L_09640	1.581e-40	153.0	COG0399@1|root,COG0399@2|Bacteria,1G88E@1117|Cyanobacteria	1117|Cyanobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD2_k127_5762913_4	234267.Acid_2199	1.021e-82	291.0	COG0477@1|root,COG2814@2|Bacteria,3Y2VT@57723|Acidobacteria	57723|Acidobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5762913_9	929556.Solca_0474	5.684e-38	151.0	COG2318@1|root,COG2318@2|Bacteria,4NNW4@976|Bacteroidetes,1IT5S@117747|Sphingobacteriia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_5762913_12	765420.OSCT_0874	3.194e-25	110.0	COG3467@1|root,COG3467@2|Bacteria,2G729@200795|Chloroflexi,377IP@32061|Chloroflexia	32061|Chloroflexia	S	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_5762913_2	1267535.KB906767_gene4340	1.669e-125	411.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HFD2_k127_5762913_13	1267535.KB906767_gene4339	5.199e-23	109.0	COG1266@1|root,COG1266@2|Bacteria,3Y54S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_5762913_3	234267.Acid_7262	1.804e-114	378.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5762913_16	525904.Tter_2722	3.831e-15	81.0	COG0640@1|root,COG0640@2|Bacteria,2NQ74@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HFD2_k127_5762913_5	234267.Acid_4153	3.092e-64	238.0	COG1538@1|root,COG1538@2|Bacteria,3Y5F3@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_5762913_6	639030.JHVA01000001_gene3034	1.608e-51	204.0	COG0845@1|root,COG0845@2|Bacteria,3Y4YK@57723|Acidobacteria,2JKU5@204432|Acidobacteriia	204432|Acidobacteriia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_5762913_0	671143.DAMO_1933	0.0	1298.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_5762913_14	404380.Gbem_3849	1.022e-21	97.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42XFU@68525|delta/epsilon subdivisions,2WSTK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HFD2_k127_5762913_11	1121948.AUAC01000010_gene2975	9.766e-26	124.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria,4415P@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_5762913_15	234267.Acid_1488	1.225e-19	95.0	COG3682@1|root,COG3682@2|Bacteria,3Y8QA@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD2_k127_5762913_17	404589.Anae109_1807	9.865e-07	61.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48,Peptidase_M56
HFD2_k127_5762913_10	1116472.MGMO_72c00090	1.941e-32	145.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1XFH2@135618|Methylococcales	135618|Methylococcales	P	TonB dependent receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
HFD2_k127_5821940_1	204669.Acid345_1073	3.725e-178	568.0	COG0696@1|root,COG0696@2|Bacteria,3Y2YH@57723|Acidobacteria,2JIZ0@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HFD2_k127_5821940_5	204669.Acid345_1074	2.642e-88	302.0	COG0111@1|root,COG0111@2|Bacteria,3Y3VD@57723|Acidobacteria,2JHVT@204432|Acidobacteriia	204432|Acidobacteriia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
HFD2_k127_5821940_6	204669.Acid345_3561	5.637e-84	293.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria,2JHV1@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD2_k127_5821940_4	1379698.RBG1_1C00001G0291	4.332e-114	386.0	COG0624@1|root,COG0624@2|Bacteria,2NQ4M@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
HFD2_k127_5821940_3	1198114.AciX9_2792	7.113e-151	492.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria,2JHY5@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HFD2_k127_5821940_7	1379698.RBG1_1C00001G1850	8.928e-48	181.0	COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria	2|Bacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_5821940_0	1267533.KB906741_gene446	1.401e-273	860.0	COG1297@1|root,COG1297@2|Bacteria,3Y2UT@57723|Acidobacteria,2JHIU@204432|Acidobacteriia	204432|Acidobacteriia	S	Oligopeptide transporter OPT	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_5821940_2	234267.Acid_1533	1.321e-155	504.0	COG2866@1|root,COG2866@2|Bacteria,3Y416@57723|Acidobacteria	57723|Acidobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_5838223_0	1267534.KB906758_gene2149	1.472e-64	245.0	28M93@1|root,2ZAN2@2|Bacteria,3Y2P6@57723|Acidobacteria,2JIKI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5841842_3	234267.Acid_5660	3.761e-38	150.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria	57723|Acidobacteria	H	Mur ligase, middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_5841842_0	639030.JHVA01000001_gene2518	3.385e-57	211.0	COG0204@1|root,COG0204@2|Bacteria,3Y7CW@57723|Acidobacteria,2JK8Q@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_5841842_1	1379698.RBG1_1C00001G1071	4.391e-56	201.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_5841842_2	383372.Rcas_0438	9.803e-41	160.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi,375KT@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HFD2_k127_5841842_4	204669.Acid345_0122	1.753e-10	64.0	COG1028@1|root,COG1028@2|Bacteria,3Y3FQ@57723|Acidobacteria,2JHPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_5856133_0	234267.Acid_0089	5.918e-156	502.0	COG2755@1|root,COG2755@2|Bacteria,3Y61E@57723|Acidobacteria	57723|Acidobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_5856133_1	1382356.JQMP01000001_gene971	3.968e-97	329.0	COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi,27XHM@189775|Thermomicrobia	189775|Thermomicrobia	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HFD2_k127_5896798_1	1202768.JROF01000006_gene2552	6.691e-34	138.0	arCOG01781@1|root,arCOG01781@2157|Archaea,2XSY0@28890|Euryarchaeota,23RWZ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	scm	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_5896798_0	1382359.JIAL01000001_gene2247	1.484e-228	715.0	COG0422@1|root,COG0422@2|Bacteria,3Y2TX@57723|Acidobacteria,2JHMC@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
HFD2_k127_5896798_2	234267.Acid_0954	2.905e-15	77.0	COG1408@1|root,COG1408@2|Bacteria,3Y5PS@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_5908165_3	926550.CLDAP_13460	1.077e-14	80.0	COG0717@1|root,COG0717@2|Bacteria,2G7HJ@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HFD2_k127_5908165_2	234267.Acid_5168	3.987e-36	139.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria	57723|Acidobacteria	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_5908165_0	234267.Acid_5169	2.111e-71	254.0	COG1994@1|root,COG1994@2|Bacteria,3Y4IT@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5908165_1	204669.Acid345_3835	2.008e-57	206.0	COG0531@1|root,COG0531@2|Bacteria,3Y6HV@57723|Acidobacteria,2JMCG@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_5908304_3	204669.Acid345_4472	1.7e-06	50.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria,2JHYH@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_5908304_0	1382356.JQMP01000001_gene901	2.382e-104	358.0	COG1351@1|root,COG1351@2|Bacteria,2G9ZK@200795|Chloroflexi,27XV1@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
HFD2_k127_5908304_1	225937.HP15_4155	1.374e-45	173.0	2E6D1@1|root,3310P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5908304_2	1150621.SMUL_1370	1.31e-33	141.0	COG0744@1|root,COG0744@2|Bacteria,1NXZS@1224|Proteobacteria	1224|Proteobacteria	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HFD2_k127_5929501_2	861299.J421_0786	3.256e-50	189.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZT4G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_5929501_1	234267.Acid_1536	2.682e-218	700.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_5929501_3	273121.WS0427	6.092e-09	68.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP3D@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HFD2_k127_5929501_0	1047013.AQSP01000142_gene165	2.828e-262	826.0	COG3591@1|root,COG3591@2|Bacteria,2NQEJ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HFD2_k127_5948108_1	234267.Acid_4387	1.366e-94	314.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_5948108_3	234267.Acid_4388	5.743e-66	230.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD2_k127_5948108_2	1191523.MROS_0607	1.813e-87	300.0	COG0276@1|root,COG0276@2|Bacteria	2|Bacteria	H	ferrochelatase activity	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0050896,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1540,iECS88_1305.ECS88_0472,iEcE24377_1341.EcE24377A_0515	Ferrochelatase
HFD2_k127_5948108_4	1304888.ATWF01000002_gene504	9.401e-62	220.0	COG0755@1|root,COG0755@2|Bacteria,2GF7F@200930|Deferribacteres	200930|Deferribacteres	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HFD2_k127_5948108_5	234267.Acid_4237	1.797e-47	180.0	COG2386@1|root,COG2386@2|Bacteria,3Y3G1@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c-type biogenesis protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HFD2_k127_5948108_6	693661.Arcve_1373	1.282e-45	174.0	COG1131@1|root,arCOG00194@2157|Archaea,2XXA3@28890|Euryarchaeota,2467K@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HFD2_k127_5948108_7	682795.AciX8_3191	2.019e-26	123.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria,2JHS9@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5948108_9	204669.Acid345_3205	2.871e-17	88.0	2EFR0@1|root,339H2@2|Bacteria,3Y5M9@57723|Acidobacteria,2JJPZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5948108_8	204669.Acid345_3206	3.27e-23	106.0	COG3088@1|root,COG3088@2|Bacteria,3Y4YV@57723|Acidobacteria,2JJM2@204432|Acidobacteriia	204432|Acidobacteriia	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HFD2_k127_5948108_0	278963.ATWD01000001_gene4156	4.021e-240	760.0	COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria,2JHQR@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD2_k127_597233_4	1340493.JNIF01000003_gene2492	1.464e-66	240.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD2_k127_597233_3	1382359.JIAL01000001_gene2413	3.743e-80	276.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria,2JIF1@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_597233_2	204669.Acid345_2890	4.39e-85	289.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_597233_0	1267535.KB906767_gene3956	3.627e-149	484.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria,2JINW@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD2_k127_597233_5	204669.Acid345_4287	1.748e-65	230.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria,2JJ9D@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD2_k127_597233_1	234267.Acid_2747	4.56e-96	323.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria	57723|Acidobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD2_k127_597233_6	204669.Acid345_4229	3.225e-30	123.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3Y2NW@57723|Acidobacteria,2JHNM@204432|Acidobacteriia	204432|Acidobacteriia	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD2_k127_598989_1	204669.Acid345_4354	7.206e-12	79.0	28M93@1|root,2ZAN2@2|Bacteria,3Y2P6@57723|Acidobacteria,2JIKI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_598989_3	1223410.KN050846_gene270	6.823e-06	60.0	COG4675@1|root,COG4675@2|Bacteria,4NKVG@976|Bacteroidetes,1HZY6@117743|Flavobacteriia	976|Bacteroidetes	S	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_598989_0	926566.Terro_0130	4.331e-16	92.0	2EKZZ@1|root,33EPG@2|Bacteria,3Y5U9@57723|Acidobacteria,2JKFN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Lipase_GDSL_2
HFD2_k127_5990532_0	1267535.KB906767_gene3272	1.483e-219	704.0	COG1506@1|root,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria,2JHN3@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HFD2_k127_5990532_3	264732.Moth_2019	5.833e-38	145.0	COG1917@1|root,COG1917@2|Bacteria,1V6IB@1239|Firmicutes,24JTU@186801|Clostridia,42H4U@68295|Thermoanaerobacterales	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_5990532_1	1382359.JIAL01000001_gene1838	2.139e-214	678.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HFD2_k127_5990532_4	671143.DAMO_0611	1.21e-35	152.0	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HFD2_k127_5990532_2	639030.JHVA01000001_gene3441	4.932e-38	150.0	COG1595@1|root,COG1595@2|Bacteria,3Y536@57723|Acidobacteria,2JJK1@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5990532_6	639030.JHVA01000001_gene3439	5.189e-22	104.0	COG3678@1|root,COG3678@2|Bacteria,3Y5A6@57723|Acidobacteria,2JJQD@204432|Acidobacteriia	204432|Acidobacteriia	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HFD2_k127_5990532_5	143224.JQMD01000002_gene4276	2.749e-31	130.0	COG0526@1|root,COG0526@2|Bacteria,4NNU2@976|Bacteroidetes,1I22P@117743|Flavobacteriia	976|Bacteroidetes	CO	alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_6017313_0	234267.Acid_3991	2.063e-163	537.0	COG0577@1|root,COG0577@2|Bacteria,3Y44G@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6017313_1	251221.35211765	5.696e-134	443.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_602361_3	1121481.AUAS01000009_gene46	7.73e-09	60.0	COG1595@1|root,COG1595@2|Bacteria,4NQPI@976|Bacteroidetes,47RJK@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_602361_1	1267535.KB906767_gene1535	6.961e-114	389.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_602361_0	204669.Acid345_2300	4.091e-211	682.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria,2JMJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HFD2_k127_6040466_4	234267.Acid_5068	0.0001415	48.0	2FHPT@1|root,349HD@2|Bacteria,3Y8EI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6040466_1	204669.Acid345_0278	5.501e-79	272.0	COG1624@1|root,COG1624@2|Bacteria,3Y7NU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
HFD2_k127_6040466_2	204669.Acid345_0277	1.505e-11	69.0	COG4856@1|root,COG4856@2|Bacteria,3Y8QK@57723|Acidobacteria	57723|Acidobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HFD2_k127_6040466_0	1382359.JIAL01000001_gene2058	1.047e-130	432.0	COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria,2JHU9@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_6040466_3	316274.Haur_4258	2.357e-05	53.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TPR_11,TPR_16,TPR_2,TPR_8,UnbV_ASPIC,VCBS
HFD2_k127_6047470_3	706587.Desti_1989	1.432e-07	59.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	ko:K06006,ko:K07803	ko02020,map02020	-	-	-	ko00000,ko00001,ko03110	-	-	-	LTXXQ,Metal_resist
HFD2_k127_6047470_0	204669.Acid345_1717	1.349e-25	115.0	COG0500@1|root,COG0500@2|Bacteria,3Y4Q0@57723|Acidobacteria,2JJCW@204432|Acidobacteriia	204432|Acidobacteriia	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_6047470_2	1267534.KB906756_gene496	1.213e-14	81.0	COG1664@1|root,COG1664@2|Bacteria,3Y5MK@57723|Acidobacteria,2JJXQ@204432|Acidobacteriia	204432|Acidobacteriia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_6047470_1	234267.Acid_3847	9.689e-17	89.0	COG1434@1|root,COG1434@2|Bacteria,3Y8M4@57723|Acidobacteria	57723|Acidobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD2_k127_6071253_0	489825.LYNGBM3L_43410	9.29e-162	529.0	COG1680@1|root,COG1680@2|Bacteria,1G7C0@1117|Cyanobacteria,1HD9W@1150|Oscillatoriales	1117|Cyanobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HFD2_k127_6071253_1	204669.Acid345_1426	1.351e-87	298.0	COG1024@1|root,COG1024@2|Bacteria,3Y3SE@57723|Acidobacteria,2JIII@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_6071253_2	526227.Mesil_2180	4.18e-06	49.0	COG0119@1|root,COG0119@2|Bacteria,1WJB4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Isopropylmalate homocitrate citramalate synthase	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_6072176_1	404380.Gbem_3239	1.27e-131	435.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD2_k127_6072176_2	234267.Acid_6727	4.79e-98	335.0	COG2239@1|root,COG2239@2|Bacteria,3Y3WD@57723|Acidobacteria	57723|Acidobacteria	P	MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
HFD2_k127_6072176_3	234267.Acid_1195	2.135e-19	99.0	COG1437@1|root,COG1437@2|Bacteria,3Y4V3@57723|Acidobacteria	57723|Acidobacteria	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HFD2_k127_6072176_0	204669.Acid345_2697	1.886e-214	683.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria,2JHTC@204432|Acidobacteriia	204432|Acidobacteriia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD2_k127_6075764_1	1267535.KB906767_gene5004	8.363e-43	159.0	COG0640@1|root,COG0640@2|Bacteria,3Y5ZP@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_6075764_0	1267535.KB906767_gene5005	2.478e-107	356.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HFD2_k127_6077259_9	682795.AciX8_1186	0.0002177	44.0	COG1385@1|root,COG1385@2|Bacteria,3Y3XJ@57723|Acidobacteria,2JI6A@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD2_k127_6077259_2	234267.Acid_0734	3.002e-139	452.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria	57723|Acidobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_6077259_7	1122919.KB905588_gene4060	1.527e-31	132.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD2_k127_6077259_5	204669.Acid345_3244	3.193e-75	266.0	COG1420@1|root,COG1420@2|Bacteria,3Y2JI@57723|Acidobacteria,2JI0D@204432|Acidobacteriia	204432|Acidobacteriia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HFD2_k127_6077259_0	1379698.RBG1_1C00001G0471	1.833e-241	754.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_6077259_8	234267.Acid_2477	8.715e-12	74.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.17,3.5.1.28	ko:K01185,ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
HFD2_k127_6077259_3	234267.Acid_2476	3.656e-136	450.0	COG0265@1|root,COG0265@2|Bacteria,3Y2SD@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_6077259_1	1329516.JPST01000001_gene982	4.064e-208	656.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,4HAWA@91061|Bacilli,27AYD@186824|Thermoactinomycetaceae	91061|Bacilli	E	Aconitase family (aconitate hydratase)	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10700	Aconitase
HFD2_k127_6077259_4	717605.Theco_1792	1.034e-86	291.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,4HFTY@91061|Bacilli,26RMU@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD2_k127_6077259_6	1379698.RBG1_1C00001G0290	1.789e-51	202.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,PD40,Peptidase_M1
HFD2_k127_6093545_0	204669.Acid345_2353	0.0	1197.0	COG4447@1|root,COG4447@2|Bacteria,3Y46N@57723|Acidobacteria,2JMGI@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6093545_10	266265.Bxe_B2089	2.666e-29	131.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1K6NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_6093545_8	234267.Acid_2952	2.346e-35	141.0	COG3764@1|root,COG3764@2|Bacteria,3Y5NI@57723|Acidobacteria	57723|Acidobacteria	M	PFAM peptidase C60, sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_6093545_2	1267534.KB906754_gene3421	4.344e-135	440.0	COG0535@1|root,COG0535@2|Bacteria,3Y3TY@57723|Acidobacteria,2JHZQ@204432|Acidobacteriia	204432|Acidobacteriia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HFD2_k127_6093545_6	1382359.JIAL01000001_gene2363	2.922e-67	252.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria,2JK7Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_6093545_11	1382359.JIAL01000001_gene1271	1.489e-25	115.0	COG2823@1|root,COG2823@2|Bacteria,3Y4E1@57723|Acidobacteria,2JJ50@204432|Acidobacteriia	204432|Acidobacteriia	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6093545_5	278963.ATWD01000002_gene781	2.636e-67	248.0	COG1807@1|root,COG1807@2|Bacteria,3Y3EH@57723|Acidobacteria,2JHRT@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_6093545_1	234267.Acid_7916	1.444e-159	531.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD2_k127_6093545_7	208439.AJAP_37935	5.391e-45	177.0	COG0778@1|root,COG0778@2|Bacteria,2I97S@201174|Actinobacteria,4E49E@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_6093545_4	1047013.AQSP01000067_gene2204	1.398e-100	340.0	COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_6093545_3	1047013.AQSP01000105_gene1439	3.084e-113	381.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	MA20_31530	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_6093545_9	1128421.JAGA01000002_gene101	4.009e-34	142.0	COG0584@1|root,COG0584@2|Bacteria,2NPNS@2323|unclassified Bacteria	2|Bacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_6101640_3	234267.Acid_7127	1.428e-28	118.0	COG1691@1|root,COG1691@2|Bacteria,3Y3BX@57723|Acidobacteria	57723|Acidobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD2_k127_6101640_2	682795.AciX8_3353	6.941e-56	202.0	COG0163@1|root,COG0163@2|Bacteria,3Y2S8@57723|Acidobacteria,2JI3S@204432|Acidobacteriia	204432|Acidobacteriia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HFD2_k127_6101640_1	234267.Acid_1310	3e-97	327.0	COG0382@1|root,COG0382@2|Bacteria,3Y3CW@57723|Acidobacteria	57723|Acidobacteria	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD2_k127_6101640_0	240015.ACP_0913	3.951e-168	537.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria,2JITB@204432|Acidobacteriia	204432|Acidobacteriia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HFD2_k127_611827_0	1449126.JQKL01000064_gene52	4.667e-295	922.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,267V9@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_6159379_1	1267533.KB906738_gene2218	8.85e-53	201.0	COG0548@1|root,COG0548@2|Bacteria,3Y2IF@57723|Acidobacteria,2JIE8@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD2_k127_6159379_0	1267533.KB906738_gene2217	4.749e-96	329.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria,2JHSX@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_6159379_2	234267.Acid_2503	6.157e-35	138.0	COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria	57723|Acidobacteria	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HFD2_k127_6159379_3	278963.ATWD01000001_gene2955	0.0001089	49.0	COG0810@1|root,COG0810@2|Bacteria,3Y5XZ@57723|Acidobacteria,2JK4K@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_6167479_0	760192.Halhy_1977	2.707e-175	554.0	COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,1IY44@117747|Sphingobacteriia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD2_k127_6167479_2	242159.ABO99001	1.445e-07	63.0	COG3914@1|root,KOG4626@2759|Eukaryota,37IV9@33090|Viridiplantae,34GWN@3041|Chlorophyta	3041|Chlorophyta	GOT	O-linked N-acetylglucosamine transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_16,TPR_2,TPR_8
HFD2_k127_6167479_1	1267534.KB906759_gene1761	8.409e-58	217.0	arCOG09742@1|root,30TV4@2|Bacteria,3Y65X@57723|Acidobacteria,2JKI2@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6173230_0	204669.Acid345_1683	4.431e-241	758.0	COG0457@1|root,COG0457@2|Bacteria,3Y2Q7@57723|Acidobacteria,2JIH1@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_11,TPR_16,TPR_2,TPR_8
HFD2_k127_6173230_2	204669.Acid345_3237	7.227e-40	152.0	2EQP8@1|root,33I96@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6173230_3	204669.Acid345_3238	3.804e-30	121.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	MA20_26500	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_6173230_1	204669.Acid345_1684	3.158e-211	667.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD2_k127_6205493_8	1122223.KB890696_gene368	2.036e-18	85.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_6205493_4	1267535.KB906767_gene3895	2.26e-35	143.0	COG2172@1|root,COG2172@2|Bacteria,3Y4TY@57723|Acidobacteria,2JJGJ@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD2_k127_6205493_3	204669.Acid345_2516	2.78e-49	179.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD2_k127_6205493_6	234267.Acid_7238	2.365e-26	110.0	COG1278@1|root,COG1278@2|Bacteria,3Y5GC@57723|Acidobacteria	57723|Acidobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_6205493_5	861299.J421_6341	2.473e-27	114.0	COG1917@1|root,COG1917@2|Bacteria,1ZTY8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_6205493_1	1125863.JAFN01000001_gene1858	8.312e-137	451.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WINR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55,2.6.1.77	ko:K03851,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684,R05652	RC00006,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_6205493_0	1123261.AXDW01000024_gene2057	9.709e-202	644.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1X4D8@135614|Xanthomonadales	135614|Xanthomonadales	S	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD2_k127_6205493_2	204669.Acid345_2311	2.536e-101	347.0	2DKFZ@1|root,309D6@2|Bacteria,3Y5NS@57723|Acidobacteria,2JM02@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
HFD2_k127_6205493_7	234267.Acid_7670	1.622e-23	106.0	COG0115@1|root,COG0115@2|Bacteria,3Y6HY@57723|Acidobacteria	57723|Acidobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_6220644_2	379066.GAU_3163	2.325e-57	206.0	COG4403@1|root,COG4403@2|Bacteria	2|Bacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
HFD2_k127_6220644_0	1267535.KB906767_gene4592	2.229e-135	439.0	COG0536@1|root,COG0536@2|Bacteria,3Y2J7@57723|Acidobacteria,2JI5G@204432|Acidobacteriia	204432|Acidobacteriia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HFD2_k127_6220644_3	204669.Acid345_0021	1.498e-45	178.0	COG1057@1|root,COG1057@2|Bacteria,3Y5D2@57723|Acidobacteria,2JJNT@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_6220644_4	1340493.JNIF01000003_gene2554	1.634e-31	127.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria	57723|Acidobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HFD2_k127_6220644_1	204669.Acid345_0023	1.516e-90	310.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	57723|Acidobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HFD2_k127_6220644_5	1121403.AUCV01000002_gene591	0.0002316	45.0	COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2X6IT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD2_k127_6223716_1	1267535.KB906767_gene3728	2.763e-130	430.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_6223716_0	204669.Acid345_0770	5.645e-198	632.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
HFD2_k127_6243401_6	1324957.K933_02691	1.596e-15	85.0	arCOG04198@1|root,arCOG04198@2157|Archaea,2XU58@28890|Euryarchaeota,23UGH@183963|Halobacteria	183963|Halobacteria	Q	TIGRFAM DMSO reductase family type II enzyme, heme b subunit	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
HFD2_k127_6243401_7	596153.Alide_4612	1.445e-07	61.0	COG3381@1|root,COG3381@2|Bacteria,1RAXF@1224|Proteobacteria,2VY6I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HFD2_k127_6243401_1	945713.IALB_1976	1.943e-113	395.0	COG0348@1|root,COG0492@1|root,COG0348@2|Bacteria,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	trxB_2	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Fer4_5,Fer4_9,Pyr_redox_3
HFD2_k127_6243401_8	331113.SNE_A18330	0.0006268	50.0	2EUQE@1|root,33N63@2|Bacteria,2JGGV@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339
HFD2_k127_6243401_4	1379698.RBG1_1C00001G0743	1.272e-30	128.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
HFD2_k127_6243401_2	1267535.KB906767_gene486	7.843e-62	216.0	COG5649@1|root,COG5649@2|Bacteria,3Y4MQ@57723|Acidobacteria,2JJV2@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_6243401_5	251229.Chro_3611	9.907e-21	97.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,3VJTR@52604|Pleurocapsales	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_6243401_0	1540221.JQNI01000004_gene458	1.218e-143	471.0	COG1249@1|root,COG1249@2|Bacteria,1WM2Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_6243401_3	251221.35211731	2.76e-40	150.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HFD2_k127_6251206_3	1340493.JNIF01000003_gene3604	8.12e-61	214.0	COG1044@1|root,COG1044@2|Bacteria,3Y3XX@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD2	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD2_k127_6251206_2	596324.TREVI0001_0424	3.116e-80	274.0	COG3142@1|root,COG3142@2|Bacteria,2J7H5@203691|Spirochaetes	203691|Spirochaetes	P	Participates in the control of copper homeostasis	cutC	-	-	ko:K06201	-	-	-	-	ko00000	-	-	-	CutC
HFD2_k127_6251206_4	204669.Acid345_2344	1.889e-56	205.0	2E19M@1|root,2ZCDB@2|Bacteria,3Y4DH@57723|Acidobacteria,2JJ2T@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6251206_0	1303518.CCALI_01615	3.101e-210	674.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HFD2_k127_6251206_1	886293.Sinac_2970	8.358e-151	486.0	COG0535@1|root,COG0535@2|Bacteria,2IWZK@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
HFD2_k127_6251206_5	1303518.CCALI_00062	5.555e-55	197.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HFD2_k127_6251680_1	404380.Gbem_4005	2.626e-22	98.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,42RBE@68525|delta/epsilon subdivisions,2WN7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_6251680_0	404380.Gbem_4004	0.0	1047.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD2_k127_6255396_2	1191523.MROS_0856	4.446e-25	106.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_6255396_0	224325.AF_0862	6.364e-92	308.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,245RW@183980|Archaeoglobi	183980|Archaeoglobi	L	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD2_k127_6255396_1	1220534.B655_1871	8.188e-35	135.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23NQ3@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD2_k127_6261505_7	67332.FM21_03550	9.874e-15	79.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GKQG@201174|Actinobacteria	201174|Actinobacteria	DT	Forkhead associated domain	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
HFD2_k127_6261505_2	204669.Acid345_4458	2.947e-65	245.0	COG0515@1|root,COG0515@2|Bacteria,3Y8AD@57723|Acidobacteria,2JND1@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_6261505_8	1294265.JCM21738_4856	1.537e-05	56.0	COG2227@1|root,COG2227@2|Bacteria,1V1FG@1239|Firmicutes,4HFP0@91061|Bacilli,1ZFTU@1386|Bacillus	91061|Bacilli	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HFD2_k127_6261505_1	204669.Acid345_4458	1.519e-72	270.0	COG0515@1|root,COG0515@2|Bacteria,3Y8AD@57723|Acidobacteria,2JND1@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_6261505_3	1123261.AXDW01000004_gene2959	7.413e-59	207.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,1STUQ@1236|Gammaproteobacteria,1XBHR@135614|Xanthomonadales	135614|Xanthomonadales	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_6261505_5	644966.Tmar_0739	1.207e-33	145.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1UIY4@1239|Firmicutes,25EZX@186801|Clostridia	186801|Clostridia	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,GGDEF
HFD2_k127_6261505_0	1267534.KB906756_gene249	6.393e-118	386.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_6261505_6	234267.Acid_5312	3.952e-29	122.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HFD2_k127_6261505_4	266117.Rxyl_0743	4.078e-35	135.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CPTD@84995|Rubrobacteria	84995|Rubrobacteria	HP	UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HFD2_k127_6264361_10	318161.Sden_0268	8.316e-09	59.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,2Q9E5@267890|Shewanellaceae	1236|Gammaproteobacteria	G	hydrolase, subfamily IA, variant 3	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756	HAD_2
HFD2_k127_6264361_0	1382359.JIAL01000001_gene1582	1.567e-106	361.0	COG4198@1|root,COG4198@2|Bacteria,3Y2H9@57723|Acidobacteria,2JIN5@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD2_k127_6264361_8	1267535.KB906767_gene415	1.43e-25	110.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD2_k127_6264361_3	204669.Acid345_2094	4.528e-41	158.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
HFD2_k127_6264361_2	234267.Acid_7868	1.17e-78	273.0	COG1230@1|root,COG1230@2|Bacteria,3Y32W@57723|Acidobacteria	57723|Acidobacteria	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HFD2_k127_6264361_1	204669.Acid345_4119	2.428e-90	313.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_6264361_4	379066.GAU_0448	8.015e-41	153.0	COG0599@1|root,COG0599@2|Bacteria,1ZTRJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_6264361_5	234267.Acid_6292	1.74e-30	128.0	COG3127@1|root,COG3127@2|Bacteria,3Y7ZT@57723|Acidobacteria	57723|Acidobacteria	Q	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6264361_6	1267535.KB906767_gene2392	7.069e-28	119.0	COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria	57723|Acidobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
HFD2_k127_6264361_7	1396418.BATQ01000007_gene1447	1.659e-27	121.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
HFD2_k127_6268376_3	1382359.JIAL01000001_gene143	4.317e-26	111.0	COG0477@1|root,COG2814@2|Bacteria,3Y47I@57723|Acidobacteria,2JJ64@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_6268376_4	309801.trd_1834	7.815e-06	54.0	COG0745@1|root,COG0745@2|Bacteria,2GBFY@200795|Chloroflexi,27ZCG@189775|Thermomicrobia	189775|Thermomicrobia	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6268376_0	639030.JHVA01000001_gene539	4.34e-57	214.0	COG0845@1|root,COG0845@2|Bacteria,3Y43D@57723|Acidobacteria,2JHRU@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_6268376_2	1198114.AciX9_3387	8.125e-33	146.0	COG1807@1|root,COG1807@2|Bacteria,3Y2T0@57723|Acidobacteria,2JIGT@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_6268376_1	1340493.JNIF01000003_gene2498	1.122e-36	146.0	COG0577@1|root,COG0577@2|Bacteria,3Y3ZQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_6279623_0	204669.Acid345_3357	1.499e-275	872.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HFD2_k127_6279623_1	204669.Acid345_3356	5.621e-181	580.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_6286470_2	204669.Acid345_1743	1.759e-36	144.0	COG1063@1|root,COG1063@2|Bacteria,3Y2H8@57723|Acidobacteria,2JIHW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_6286470_0	204669.Acid345_1744	6.94e-128	421.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria,2JIRR@204432|Acidobacteriia	204432|Acidobacteriia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_6286470_1	234267.Acid_1265	2.25e-79	271.0	COG1562@1|root,COG1562@2|Bacteria,3Y3ZV@57723|Acidobacteria	57723|Acidobacteria	I	PFAM Squalene phytoene synthase	-	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HFD2_k127_6289731_0	661478.OP10G_1347	1.079e-183	591.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD2_k127_6289731_1	204669.Acid345_0712	2.377e-134	434.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_6289731_2	234267.Acid_0080	1.85e-09	63.0	COG0842@1|root,COG1228@1|root,COG0842@2|Bacteria,COG1228@2|Bacteria,3Y750@57723|Acidobacteria	57723|Acidobacteria	QV	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,Amidohydro_1
HFD2_k127_6293161_3	1267535.KB906767_gene4789	2.946e-92	309.0	COG1064@1|root,COG1064@2|Bacteria,3Y34K@57723|Acidobacteria,2JIU5@204432|Acidobacteriia	204432|Acidobacteriia	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD2_k127_6293161_0	398767.Glov_1587	2.419e-221	715.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
HFD2_k127_6293161_4	330214.NIDE1529	1.085e-61	222.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HFD2_k127_6293161_7	706587.Desti_3086	7.965e-39	155.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,42S8N@68525|delta/epsilon subdivisions,2WNCI@28221|Deltaproteobacteria,2MRX8@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HFD2_k127_6293161_1	56780.SYN_01481	1.434e-155	520.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HFD2_k127_6293161_12	391587.KAOT1_18957	4.051e-05	58.0	COG4935@1|root,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia	976|Bacteroidetes	O	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,P_proprotein,Reprolysin_4,TSP_3
HFD2_k127_6293161_10	35754.JNYJ01000007_gene2903	1.134e-06	63.0	COG4932@1|root,COG5295@1|root,COG4932@2|Bacteria,COG5295@2|Bacteria,2I434@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF11,SdrD_B
HFD2_k127_6293161_2	484770.UFO1_1101	6.383e-143	499.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_6293161_6	234267.Acid_7407	3.784e-47	181.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,3Y4FC@57723|Acidobacteria	57723|Acidobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD2_k127_6293161_8	234267.Acid_0319	2.598e-31	134.0	COG0705@1|root,COG0705@2|Bacteria,3Y4GU@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HFD2_k127_6293161_9	1519464.HY22_13385	3.06e-22	102.0	COG0589@1|root,COG0589@2|Bacteria,1FDX7@1090|Chlorobi	1090|Chlorobi	T	PFAM UspA domain protein	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HFD2_k127_6293161_5	1303518.CCALI_01862	1.927e-52	198.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278,ko:K06889	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	PD40,Peptidase_S9
HFD2_k127_6309614_0	379066.GAU_3347	4.985e-88	302.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	dppA	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
HFD2_k127_6309614_4	1267535.KB906767_gene5528	8.212e-40	160.0	COG0546@1|root,COG0546@2|Bacteria,3Y7JG@57723|Acidobacteria	57723|Acidobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K11777	-	-	-	-	ko00000	-	-	-	HAD_2
HFD2_k127_6309614_1	234267.Acid_3854	1.181e-81	284.0	COG0079@1|root,COG0079@2|Bacteria,3Y3M6@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_6309614_3	67352.JODS01000015_gene7031	6.684e-46	181.0	COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_6309614_2	278963.ATWD01000002_gene526	1.764e-55	199.0	COG0761@1|root,COG0761@2|Bacteria,3Y40M@57723|Acidobacteria,2JIXC@204432|Acidobacteriia	204432|Acidobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD2_k127_6315298_0	204669.Acid345_0973	4.881e-136	462.0	COG4585@1|root,COG4585@2|Bacteria,3Y8CF@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_6315298_1	204669.Acid345_0972	1.36e-77	267.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria,2JIR0@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_6315298_3	1382359.JIAL01000001_gene778	3.681e-55	200.0	COG0283@1|root,COG0283@2|Bacteria,3Y4MV@57723|Acidobacteria,2JJ7N@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD2_k127_6315298_2	204669.Acid345_3219	7.438e-74	257.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia	204432|Acidobacteriia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD2_k127_6320506_2	204669.Acid345_0261	3.881e-62	219.0	COG0233@1|root,COG0233@2|Bacteria,3Y4AP@57723|Acidobacteria,2JJ0X@204432|Acidobacteriia	204432|Acidobacteriia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD2_k127_6320506_0	204669.Acid345_3005	2.471e-137	462.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,3Y5KB@57723|Acidobacteria,2JHVK@204432|Acidobacteriia	204432|Acidobacteriia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
HFD2_k127_6320506_3	204669.Acid345_1221	5.488e-62	216.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria,2JJ7D@204432|Acidobacteriia	204432|Acidobacteriia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD2_k127_6320506_1	1382359.JIAL01000001_gene1692	1.006e-65	228.0	COG0049@1|root,COG0049@2|Bacteria,3Y37A@57723|Acidobacteria,2JHRA@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD2_k127_6320506_4	1235797.C816_00729	2.024e-37	141.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,2N72W@216572|Oscillospiraceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_6328515_1	234267.Acid_7680	8.874e-12	66.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_6328515_0	234267.Acid_4431	6.736e-259	826.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_6335488_0	861299.J421_5960	6.906e-130	432.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6335488_1	68219.JNXI01000002_gene3959	1.995e-91	309.0	2EYIJ@1|root,33RSC@2|Bacteria,2IPA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6335488_2	1267535.KB906767_gene1533	3.621e-23	103.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_6365884_1	522772.Dacet_2900	5.987e-61	214.0	COG0280@1|root,COG0280@2|Bacteria,2GEYU@200930|Deferribacteres	200930|Deferribacteres	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HFD2_k127_6365884_0	234267.Acid_7944	4.653e-162	541.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6365884_2	1038867.AXAY01000014_gene5107	2.034e-12	71.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2UAKC@28211|Alphaproteobacteria,3JUS4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
HFD2_k127_6366558_7	234267.Acid_0913	2.593e-28	117.0	COG0321@1|root,COG0321@2|Bacteria,3Y448@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
HFD2_k127_6366558_0	1382359.JIAL01000001_gene1188	4.895e-178	569.0	COG1249@1|root,COG1249@2|Bacteria,3Y2M8@57723|Acidobacteria,2JIAI@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_6366558_6	204669.Acid345_4135	4.445e-35	137.0	COG1734@1|root,COG1734@2|Bacteria,3Y5PJ@57723|Acidobacteria,2JK2N@204432|Acidobacteriia	204432|Acidobacteriia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD2_k127_6366558_5	1408323.JQKK01000013_gene981	2.044e-35	146.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,27MSJ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
HFD2_k127_6366558_3	1340493.JNIF01000003_gene2823	8.108e-77	262.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria	57723|Acidobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD2_k127_6366558_10	177437.HRM2_48590	1.873e-11	69.0	COG1225@1|root,COG1225@2|Bacteria,1NN23@1224|Proteobacteria,42XJF@68525|delta/epsilon subdivisions,2WTAE@28221|Deltaproteobacteria,2MNXB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
HFD2_k127_6366558_1	204669.Acid345_4119	4.054e-104	347.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_6366558_2	278963.ATWD01000001_gene3608	8.428e-97	335.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria,2JI3V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6366558_9	204669.Acid345_0097	4.524e-16	85.0	2DNWY@1|root,32UJU@2|Bacteria,3Y584@57723|Acidobacteria,2JJRR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2393)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2393
HFD2_k127_6366558_4	1198114.AciX9_3565	1.499e-72	252.0	COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia	204432|Acidobacteriia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD2_k127_6366558_8	887898.HMPREF0551_1619	1.217e-19	89.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,1JZW6@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_6374280_0	296591.Bpro_4325	8.621e-128	439.0	COG3266@1|root,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria,2WHG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6374280_3	1340493.JNIF01000003_gene1849	3.994e-11	77.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_6374280_2	246197.MXAN_5221	5.482e-23	104.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	ko:K18991	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	AraC_binding,Cupin_6,HTH_18,HTH_AraC
HFD2_k127_6374280_1	909663.KI867150_gene69	4.007e-68	241.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_637757_3	478741.JAFS01000001_gene1240	2.816e-61	212.0	COG0050@1|root,COG0050@2|Bacteria,46SFG@74201|Verrucomicrobia,37G2A@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_637757_7	278963.ATWD01000001_gene4332	7.925e-16	78.0	COG0267@1|root,COG0267@2|Bacteria,3Y5UB@57723|Acidobacteria,2JJXX@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HFD2_k127_637757_8	278963.ATWD01000001_gene4333	2.987e-09	63.0	COG0690@1|root,COG0690@2|Bacteria,3Y5R4@57723|Acidobacteria,2JK14@204432|Acidobacteriia	204432|Acidobacteriia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HFD2_k127_637757_2	204669.Acid345_4681	4.329e-81	276.0	COG0250@1|root,COG0250@2|Bacteria,3Y3ZR@57723|Acidobacteria,2JHU8@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HFD2_k127_637757_4	224324.aq_1933	1.561e-52	188.0	COG0080@1|root,COG0080@2|Bacteria,2G41D@200783|Aquificae	200783|Aquificae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HFD2_k127_637757_1	525903.Taci_1510	1.551e-86	293.0	COG0081@1|root,COG0081@2|Bacteria,3T9SR@508458|Synergistetes	508458|Synergistetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HFD2_k127_637757_5	234267.Acid_5459	6.615e-48	178.0	COG0244@1|root,COG0244@2|Bacteria,3Y4N2@57723|Acidobacteria	57723|Acidobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HFD2_k127_637757_6	204669.Acid345_4677	8.433e-42	157.0	COG0222@1|root,COG0222@2|Bacteria,3Y50J@57723|Acidobacteria,2JJHE@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HFD2_k127_637757_0	234267.Acid_5457	0.0	1527.0	COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria	57723|Acidobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HFD2_k127_6397313_1	555088.DealDRAFT_0893	7.225e-101	339.0	COG1073@1|root,COG1073@2|Bacteria,1TSFY@1239|Firmicutes,24ETS@186801|Clostridia	186801|Clostridia	M	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	CW_binding_2,Cu_amine_oxidN1,DLH,DUF3887,Hydrolase_4,Peptidase_S9
HFD2_k127_6397313_2	1379270.AUXF01000001_gene2022	5.609e-16	80.0	COG4877@1|root,COG4877@2|Bacteria,1ZVAE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6397313_0	1121875.KB907556_gene591	1.191e-163	528.0	COG1473@1|root,COG1473@2|Bacteria,4NEKH@976|Bacteroidetes,1HZT3@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Peptidase M20	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_6397313_3	518766.Rmar_1764	8.733e-12	70.0	COG3408@1|root,COG3408@2|Bacteria,4PJ05@976|Bacteroidetes,1FJS7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6432197_2	682795.AciX8_3304	1.026e-43	170.0	COG0136@1|root,COG0136@2|Bacteria,3Y395@57723|Acidobacteria,2JI31@204432|Acidobacteriia	204432|Acidobacteriia	E	Semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_6432197_3	401053.AciPR4_0677	6.543e-28	121.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria,2JJKB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
HFD2_k127_6432197_5	404589.Anae109_2450	4.391e-11	74.0	COG1466@1|root,COG1466@2|Bacteria,1RAEB@1224|Proteobacteria,42R0X@68525|delta/epsilon subdivisions,2WMQJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III, delta'	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HFD2_k127_6432197_4	1382359.JIAL01000001_gene2110	4.298e-18	87.0	COG0268@1|root,COG0268@2|Bacteria,3Y5CZ@57723|Acidobacteria,2JJS9@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD2_k127_6432197_0	1128427.KB904821_gene4236	4.845e-123	413.0	COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria,1HE1K@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD2_k127_6432197_1	913325.N799_08525	4.215e-60	214.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S5WE@1236|Gammaproteobacteria,1X3ZI@135614|Xanthomonadales	135614|Xanthomonadales	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_6434048_0	671143.DAMO_1540	1.363e-66	236.0	COG3769@1|root,COG3769@2|Bacteria,2NR7G@2323|unclassified Bacteria	2|Bacteria	S	haloacid dehalogenase-like hydrolase	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051	-	R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Hydrolase_3
HFD2_k127_6434048_1	330214.NIDE4206	1.528e-22	106.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
HFD2_k127_649348_0	1157490.EL26_22765	7.532e-19	91.0	COG4539@1|root,COG4539@2|Bacteria,1VJFX@1239|Firmicutes,4HQE3@91061|Bacilli,27A12@186823|Alicyclobacillaceae	91061|Bacilli	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HFD2_k127_649348_2	1382359.JIAL01000001_gene2225	5.072e-06	56.0	28J2W@1|root,2Z8Z6@2|Bacteria,3Y2KF@57723|Acidobacteria,2JIUG@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_649348_1	234267.Acid_3848	3.456e-10	68.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HFD2_k127_6519457_3	525904.Tter_0412	2.57e-11	69.0	COG0363@1|root,COG0363@2|Bacteria,2NPBM@2323|unclassified Bacteria	2|Bacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD2_k127_6519457_0	357808.RoseRS_2562	1.736e-179	578.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_6519457_1	1267535.KB906767_gene3854	9.324e-152	486.0	COG1023@1|root,COG1023@2|Bacteria,3Y2ZP@57723|Acidobacteria,2JJT6@204432|Acidobacteriia	204432|Acidobacteriia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD2_k127_6519457_2	1047013.AQSP01000139_gene2343	4.397e-63	220.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_6531052_1	1379270.AUXF01000003_gene3442	1.471e-73	250.0	COG1966@1|root,COG1966@2|Bacteria,1ZSWX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HFD2_k127_6531052_0	204669.Acid345_3619	1.923e-107	354.0	COG1966@1|root,COG1966@2|Bacteria,3Y436@57723|Acidobacteria,2JKKA@204432|Acidobacteriia	204432|Acidobacteriia	T	Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HFD2_k127_6531052_2	671143.DAMO_1603	1.27e-41	159.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD2_k127_6531052_3	525904.Tter_1818	1.069e-31	133.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6532859_2	204669.Acid345_3344	1.107e-34	138.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD2_k127_6532859_0	240015.ACP_3307	2.089e-160	514.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	204432|Acidobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD2_k127_6532859_4	648885.KB316283_gene2768	3.87e-23	104.0	arCOG09511@1|root,2Z9DH@2|Bacteria,1MXRV@1224|Proteobacteria,2UBCS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM FRG domain	-	-	-	-	-	-	-	-	-	-	-	-	FRG
HFD2_k127_6532859_3	221288.JH992901_gene1225	7.44e-34	136.0	COG1672@1|root,COG1672@2|Bacteria,1GCFZ@1117|Cyanobacteria,1JK9S@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HFD2_k127_6532859_1	748727.CLJU_c14900	9.981e-46	176.0	COG0657@1|root,COG0657@2|Bacteria,1UFB9@1239|Firmicutes,24DFS@186801|Clostridia,36HTV@31979|Clostridiaceae	186801|Clostridia	I	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD2_k127_6549984_1	671143.DAMO_1539	1.641e-149	485.0	COG0463@1|root,COG0463@2|Bacteria,2NQD9@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
HFD2_k127_6549984_0	671143.DAMO_1541	1.63e-158	513.0	COG1215@1|root,COG1215@2|Bacteria,2NNSB@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
HFD2_k127_6549984_3	1379270.AUXF01000003_gene3811	8.967e-60	213.0	COG0586@1|root,COG0586@2|Bacteria,1ZTJB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HFD2_k127_6549984_2	204669.Acid345_2467	2.321e-64	231.0	COG1752@1|root,COG1752@2|Bacteria,3Y4B2@57723|Acidobacteria,2JJ4V@204432|Acidobacteriia	57723|Acidobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_6568885_1	290397.Adeh_1460	4.232e-28	123.0	COG2227@1|root,COG2227@2|Bacteria,1QX9R@1224|Proteobacteria,43C2X@68525|delta/epsilon subdivisions,2X7DJ@28221|Deltaproteobacteria,2Z3FT@29|Myxococcales	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_6568885_0	1210884.HG799464_gene10549	2.876e-45	167.0	COG1524@1|root,COG1524@2|Bacteria,2IYCV@203682|Planctomycetes	203682|Planctomycetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_6572284_3	886293.Sinac_6019	9.391e-68	243.0	29NNR@1|root,309KP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6572284_0	886293.Sinac_6020	3.943e-289	905.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,TAT_signal
HFD2_k127_6572284_2	886293.Sinac_6021	4.556e-71	245.0	COG2080@1|root,COG2080@2|Bacteria,2IZCW@203682|Planctomycetes	2|Bacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.3.99.16	ko:K07302,ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2,Fer2,Fer2_2
HFD2_k127_6572284_1	234267.Acid_0366	4.746e-177	575.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_6572284_5	234267.Acid_4092	2.675e-45	170.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_6572284_6	234267.Acid_4093	5.488e-40	159.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_6572284_4	234267.Acid_4094	2.421e-54	204.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
HFD2_k127_6572284_7	382464.ABSI01000020_gene324	1.587e-18	90.0	COG3595@1|root,COG3595@2|Bacteria,46W9C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6635832_0	204669.Acid345_1255	2.893e-123	400.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria,2JHZ6@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HFD2_k127_6635832_3	1267535.KB906767_gene2677	2.177e-44	165.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria,2JJ8Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HFD2_k127_6635832_1	1128421.JAGA01000003_gene3653	2.348e-115	394.0	COG3975@1|root,COG3975@2|Bacteria,2NQU3@2323|unclassified Bacteria	2|Bacteria	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HFD2_k127_6635832_4	1382359.JIAL01000001_gene2220	1.524e-15	84.0	COG5652@1|root,COG5652@2|Bacteria,3Y82N@57723|Acidobacteria,2JND5@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HFD2_k127_6635832_2	1123376.AUIU01000007_gene1179	3.022e-70	241.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD2_k127_6678583_0	234267.Acid_3510	7.247e-99	338.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,3Y6TD@57723|Acidobacteria	57723|Acidobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_20,Pyr_redox_2
HFD2_k127_6678583_2	1125863.JAFN01000001_gene2795	1.817e-41	158.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD2_k127_6678583_1	1125863.JAFN01000001_gene2794	3.702e-77	264.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_6697875_0	1123248.KB893315_gene3017	9.688e-49	179.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_6697875_2	1232410.KI421412_gene247	9.184e-45	178.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HFD2_k127_6697875_1	886293.Sinac_6608	6.943e-46	179.0	COG0500@1|root,COG2226@2|Bacteria,2J1F4@203682|Planctomycetes	203682|Planctomycetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_6701056_0	1444309.JAQG01000033_gene2967	2.449e-76	261.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae	91061|Bacilli	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA_2	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HFD2_k127_6701056_1	234267.Acid_5607	5.847e-48	186.0	COG0454@1|root,COG0456@2|Bacteria,3Y8PW@57723|Acidobacteria	57723|Acidobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6701056_2	760568.Desku_2926	4.616e-15	76.0	COG1024@1|root,COG1024@2|Bacteria,1U9P5@1239|Firmicutes,24D6S@186801|Clostridia,264NC@186807|Peptococcaceae	186801|Clostridia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_6708560_0	204669.Acid345_4326	2.422e-77	267.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_6708560_3	756272.Plabr_3437	9.402e-31	128.0	COG2010@1|root,COG2010@2|Bacteria,2J3TA@203682|Planctomycetes	203682|Planctomycetes	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HFD2_k127_6708560_1	1242864.D187_006808	5.07e-51	190.0	COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42P2D@68525|delta/epsilon subdivisions,2WKSQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_6708560_2	1267535.KB906767_gene1124	2.846e-40	152.0	COG0577@1|root,COG0577@2|Bacteria,3Y6YF@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_6728322_0	195250.CM001776_gene292	2.245e-08	57.0	COG0672@1|root,COG0672@2|Bacteria,1G047@1117|Cyanobacteria,1GZUD@1129|Synechococcus	1117|Cyanobacteria	P	Iron permease FTR1 family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HFD2_k127_6728322_1	999541.bgla_1g01610	7.638e-08	64.0	COG4796@1|root,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,1K5MF@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
HFD2_k127_6766920_3	1382359.JIAL01000001_gene2930	5.288e-25	111.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria,2JHJ5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_6766920_0	1267535.KB906767_gene4620	3.306e-69	246.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_6766920_2	204669.Acid345_2680	4.469e-63	231.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD2_k127_6766920_4	1340493.JNIF01000003_gene2257	2.733e-20	94.0	COG1826@1|root,COG1826@2|Bacteria,3Y5TY@57723|Acidobacteria	57723|Acidobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_6766920_1	204669.Acid345_2676	1.571e-64	234.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria,2JHNE@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD2_k127_6839343_7	1077972.ARGLB_035_00140	1.198e-19	92.0	COG3621@1|root,COG3621@2|Bacteria,2I97F@201174|Actinobacteria,1WAYR@1268|Micrococcaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_6839343_0	661478.OP10G_3165	1.02e-150	508.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6839343_8	926562.Oweho_0444	2.62e-08	63.0	COG1309@1|root,COG1309@2|Bacteria,4PA81@976|Bacteroidetes,1IMRV@117743|Flavobacteriia,2PBT4@246874|Cryomorphaceae	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_6839343_4	795797.C497_08983	1.918e-48	177.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XX7K@28890|Euryarchaeota,23VK2@183963|Halobacteria	183963|Halobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_6839343_2	706587.Desti_2256	9.808e-75	258.0	COG3945@1|root,COG3945@2|Bacteria,1NX3S@1224|Proteobacteria,430RH@68525|delta/epsilon subdivisions,2WVY3@28221|Deltaproteobacteria,2MS02@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_6839343_3	204669.Acid345_1322	8.932e-52	189.0	COG2259@1|root,COG2259@2|Bacteria,3Y82A@57723|Acidobacteria,2JN7Q@204432|Acidobacteriia	204432|Acidobacteriia	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD2_k127_6839343_6	1123008.KB905694_gene1862	2.438e-28	123.0	COG0730@1|root,COG0730@2|Bacteria,4P9IK@976|Bacteroidetes,2FZEW@200643|Bacteroidia	976|Bacteroidetes	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HFD2_k127_6839343_5	1123368.AUIS01000035_gene82	9.155e-40	151.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,1S9PQ@1236|Gammaproteobacteria,2ND29@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD2_k127_6839343_1	1267533.KB906733_gene3549	1.38e-76	258.0	COG0450@1|root,COG0450@2|Bacteria,3Y444@57723|Acidobacteria,2JIZK@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HFD2_k127_6840813_1	41431.PCC8801_3355	7.397e-109	370.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,3KHG3@43988|Cyanothece	1117|Cyanobacteria	GM	PFAM ABC transporter related	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HFD2_k127_6840813_2	237368.SCABRO_01358	3.212e-108	358.0	COG1682@1|root,COG1682@2|Bacteria,2IYXC@203682|Planctomycetes	203682|Planctomycetes	U	COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HFD2_k127_6840813_9	1267534.KB906755_gene4130	3.113e-37	146.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
HFD2_k127_6840813_5	682795.AciX8_1493	3.168e-55	211.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD2_k127_6840813_11	1267535.KB906767_gene3509	7.797e-09	68.0	COG2956@1|root,COG2956@2|Bacteria	2|Bacteria	G	lipopolysaccharide metabolic process	-	-	-	ko:K08309,ko:K19804	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD2_k127_6840813_0	682795.AciX8_1492	1.086e-131	449.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia	57723|Acidobacteria	D	G-rich domain on putative tyrosine kinase	-	-	2.7.10.1	ko:K08252,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
HFD2_k127_6840813_4	1267533.KB906741_gene509	1.111e-55	203.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HFD2_k127_6840813_10	661478.OP10G_2386	5.792e-21	101.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	Polyketide_cyc2
HFD2_k127_6840813_3	330214.NIDE0045	1.003e-89	301.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_6840813_7	204669.Acid345_3981	9.129e-42	154.0	COG2318@1|root,COG2318@2|Bacteria,3Y53M@57723|Acidobacteria,2JN3W@204432|Acidobacteriia	204432|Acidobacteriia	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_6846275_4	278963.ATWD01000002_gene781	1.389e-41	164.0	COG1807@1|root,COG1807@2|Bacteria,3Y3EH@57723|Acidobacteria,2JHRT@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_6846275_2	204669.Acid345_3484	2.85e-139	453.0	COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HFD2_k127_6846275_3	204669.Acid345_2245	2.093e-116	391.0	COG0053@1|root,COG0053@2|Bacteria,3Y43E@57723|Acidobacteria,2JIIM@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD2_k127_6846275_0	401053.AciPR4_1363	6.536e-179	577.0	COG0666@1|root,COG0666@2|Bacteria,3Y3EY@57723|Acidobacteria	57723|Acidobacteria	S	ankyrin repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6846275_5	861299.J421_0909	1.072e-13	78.0	COG2940@1|root,COG2940@2|Bacteria,1ZTR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD2_k127_6846275_6	1282360.ABAC460_22490	0.0001053	53.0	COG3832@1|root,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2UCMP@28211|Alphaproteobacteria,2KIKY@204458|Caulobacterales	204458|Caulobacterales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_6846275_1	1379698.RBG1_1C00001G0509	2.555e-149	492.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_686809_0	760568.Desku_3528	3.111e-82	278.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,263QH@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_686809_2	204669.Acid345_0805	7.68e-37	145.0	COG1225@1|root,COG1225@2|Bacteria,3Y8N3@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_686809_1	867845.KI911784_gene3494	8.21e-78	269.0	COG0446@1|root,COG0446@2|Bacteria,2G68U@200795|Chloroflexi,3771J@32061|Chloroflexia	32061|Chloroflexia	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_6869050_3	931627.MycrhDRAFT_5562	3.168e-22	111.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_6869050_4	1267533.KB906736_gene904	3.461e-18	96.0	28M52@1|root,2ZAIX@2|Bacteria,3Y2MW@57723|Acidobacteria,2JIXK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6869050_1	1254432.SCE1572_18725	7.693e-48	181.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WR0S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HFD2_k127_6869050_0	338963.Pcar_0752	1.839e-121	408.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HFD2_k127_6869050_2	1379698.RBG1_1C00001G0509	2.136e-37	145.0	COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_6873109_0	1089550.ATTH01000001_gene264	6.596e-42	170.0	COG0438@1|root,COG0438@2|Bacteria,4NTGE@976|Bacteroidetes,1FJZW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_6873109_1	929712.KI912613_gene2533	9.754e-18	97.0	COG0772@1|root,COG0772@2|Bacteria	2|Bacteria	D	peptidoglycan glycosyltransferase activity	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_6873109_2	698757.Pogu_2027	5.876e-05	49.0	COG0438@1|root,arCOG01410@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
HFD2_k127_6875321_2	485913.Krac_11396	3.703e-120	394.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_6875321_1	234267.Acid_7659	2.37e-197	625.0	COG0044@1|root,COG0044@2|Bacteria,3Y48H@57723|Acidobacteria	57723|Acidobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HFD2_k127_6875321_0	1047013.AQSP01000139_gene2342	1.044e-277	871.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_6875321_3	1168034.FH5T_11985	3.382e-15	76.0	COG2080@1|root,COG2080@2|Bacteria,4PNKJ@976|Bacteroidetes	976|Bacteroidetes	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_6896157_4	596152.DesU5LDRAFT_4089	9.562e-32	143.0	COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,43AV7@68525|delta/epsilon subdivisions,2X699@28221|Deltaproteobacteria,2MGZU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HFD2_k127_6896157_1	247490.KSU1_B0365	4.006e-123	409.0	COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes	203682|Planctomycetes	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_6896157_5	871968.DESME_00855	1.513e-28	125.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,262BX@186807|Peptococcaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_6896157_2	1382359.JIAL01000001_gene2223	9.951e-87	293.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria,2JHWI@204432|Acidobacteriia	204432|Acidobacteriia	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_6896157_0	880073.Calab_3693	7.14e-172	562.0	COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria	2|Bacteria	S	OPT oligopeptide transporter protein	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_6896157_3	401053.AciPR4_0237	1.753e-70	246.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HFD2_k127_6901026_9	204669.Acid345_0706	5.26e-17	89.0	COG2304@1|root,COG2304@2|Bacteria,3Y2QN@57723|Acidobacteria,2JI49@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6901026_5	682795.AciX8_1002	1.427e-79	278.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_6901026_3	1382359.JIAL01000001_gene553	9.449e-88	303.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria,2JI45@204432|Acidobacteriia	204432|Acidobacteriia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HFD2_k127_6901026_10	1265505.ATUG01000001_gene3015	2.114e-16	94.0	COG2199@1|root,COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42RC2@68525|delta/epsilon subdivisions,2X8JD@28221|Deltaproteobacteria,2MJQ0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
HFD2_k127_6901026_8	1121428.DESHY_110491___1	7.728e-31	141.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,263FY@186807|Peptococcaceae	186801|Clostridia	KT	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF,HD,HD_5,PAS,PAS_9
HFD2_k127_6901026_4	207559.Dde_3784	7.829e-82	289.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2M9ZU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD2_k127_6901026_6	118173.KB235914_gene1462	4.973e-59	236.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1H803@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
HFD2_k127_6901026_11	1267533.KB906741_gene641	9.615e-16	83.0	COG4319@1|root,COG4319@2|Bacteria,3Y5EF@57723|Acidobacteria,2JJP7@204432|Acidobacteriia	204432|Acidobacteriia	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_6901026_2	671143.DAMO_1620	1.225e-142	468.0	COG1013@1|root,COG1013@2|Bacteria,2NPAM@2323|unclassified Bacteria	2|Bacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	korB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_6901026_0	671143.DAMO_1619	4.424e-245	771.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NPPN@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD2_k127_6901026_1	234267.Acid_5979	1.381e-213	692.0	COG2366@1|root,COG2366@2|Bacteria,3Y2PX@57723|Acidobacteria	2|Bacteria	S	PFAM peptidase S45 penicillin amidase	penA	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD2_k127_6901026_7	1382359.JIAL01000001_gene398	2.021e-44	167.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria,2JIJ3@204432|Acidobacteriia	204432|Acidobacteriia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD2_k127_6901247_9	1382359.JIAL01000001_gene911	1.891e-10	63.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HFD2_k127_6901247_0	204669.Acid345_4522	2.424e-236	750.0	COG1200@1|root,COG1200@2|Bacteria,3Y31Z@57723|Acidobacteria,2JHRS@204432|Acidobacteriia	204432|Acidobacteriia	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD2_k127_6901247_3	234267.Acid_5720	1.178e-62	223.0	COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria	57723|Acidobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_6901247_7	639030.JHVA01000001_gene2764	4.936e-18	96.0	COG1413@1|root,COG1413@2|Bacteria,3Y2TB@57723|Acidobacteria,2JHKS@204432|Acidobacteriia	204432|Acidobacteriia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
HFD2_k127_6901247_12	1179773.BN6_69600	1.274e-05	58.0	COG3595@1|root,COG3595@2|Bacteria,2HIX2@201174|Actinobacteria,4DYUW@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_6901247_10	204669.Acid345_1494	1.941e-10	74.0	COG0810@1|root,COG2203@1|root,COG0810@2|Bacteria,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,EAL,GAF,GAF_2,GGDEF,HATPase_c,HisKA,Hpt,Response_reg,TonB_C
HFD2_k127_6901247_6	204669.Acid345_1037	3.079e-27	121.0	COG3595@1|root,COG3595@2|Bacteria,3Y97I@57723|Acidobacteria,2JNRB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6901247_4	234267.Acid_5723	7.395e-40	162.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria	57723|Acidobacteria	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HFD2_k127_6901247_14	379066.GAU_1149	0.0007086	50.0	2FH8I@1|root,3492W@2|Bacteria,1ZTXF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6901247_5	1340493.JNIF01000003_gene1559	3.001e-32	134.0	COG0703@1|root,COG0703@2|Bacteria,3Y4R0@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI,TMP-TENI
HFD2_k127_6901247_11	1379270.AUXF01000001_gene2632	3.247e-10	70.0	COG3595@1|root,COG3595@2|Bacteria,1ZU53@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_6901247_8	1047013.AQSP01000139_gene2326	6.036e-13	77.0	COG5660@1|root,COG5660@2|Bacteria	2|Bacteria	S	Putative zinc-finger	sigC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	zf-HC2
HFD2_k127_6901247_2	204669.Acid345_2486	1.763e-81	282.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria,2JHY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_6901247_1	1267533.KB906738_gene2114	3.945e-187	597.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria,2JI1W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_6901247_13	1267535.KB906767_gene968	2.283e-05	49.0	COG4591@1|root,COG4591@2|Bacteria,3Y3BU@57723|Acidobacteria,2JIC6@204432|Acidobacteriia	204432|Acidobacteriia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HFD2_k127_6965604_2	661478.OP10G_2858	5.581e-26	110.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6965604_1	1340493.JNIF01000003_gene2134	1.923e-145	470.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria	57723|Acidobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_6965604_0	1267535.KB906767_gene649	6.413e-157	502.0	COG2519@1|root,COG2519@2|Bacteria,3Y469@57723|Acidobacteria,2JIAQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_6965604_4	1449346.JQMO01000002_gene1716	3.217e-11	71.0	COG0748@1|root,COG0748@2|Bacteria,2IIRT@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD2_k127_6965604_3	1365176.N186_07155	1.278e-16	90.0	COG1748@1|root,arCOG00243@2157|Archaea,2XSMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Saccharopine dehydrogenase NADP binding domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_NADP
HFD2_k127_6987618_3	1232436.CAPF01000020_gene1025	1.231e-29	122.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUCU@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation	murB_1	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD2_k127_6987618_2	926566.Terro_3440	2.368e-51	193.0	COG1589@1|root,COG1589@2|Bacteria,3Y3BQ@57723|Acidobacteria,2JIZS@204432|Acidobacteriia	204432|Acidobacteriia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HFD2_k127_6987618_0	398767.Glov_0665	2.611e-120	399.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HFD2_k127_6987618_1	234267.Acid_7307	5.962e-94	314.0	COG0206@1|root,COG0206@2|Bacteria,3Y2WG@57723|Acidobacteria	57723|Acidobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD2_k127_699428_2	696281.Desru_2207	4.776e-19	89.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,261AQ@186807|Peptococcaceae	186801|Clostridia	U	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_699428_1	1089550.ATTH01000001_gene1443	2.228e-67	242.0	COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,1FJ56@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD2_k127_699428_0	1120797.KB908255_gene552	2.183e-90	307.0	COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,236PS@1762|Mycobacteriaceae	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_7029039_0	1267534.KB906754_gene3810	1.523e-90	306.0	COG2318@1|root,COG2318@2|Bacteria,3Y7AE@57723|Acidobacteria	57723|Acidobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_7029039_1	204669.Acid345_3253	6.059e-49	180.0	COG1607@1|root,COG1607@2|Bacteria,3Y53T@57723|Acidobacteria,2JMAX@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_7029039_3	682795.AciX8_2495	8.292e-12	73.0	COG5343@1|root,COG5343@2|Bacteria,3Y541@57723|Acidobacteria,2JJTM@204432|Acidobacteriia	204432|Acidobacteriia	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
HFD2_k127_7029039_2	880073.Calab_3717	2.494e-46	177.0	COG1232@1|root,COG1232@2|Bacteria,2NQ1W@2323|unclassified Bacteria	2|Bacteria	H	Flavin containing amine oxidoreductase	hemG	-	1.14.19.9,1.3.3.15,1.3.3.4	ko:K00231,ko:K14266	ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130	M00121,M00789,M00790	R03222,R04178,R09570	RC00885,RC00949	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
HFD2_k127_7035664_11	234267.Acid_0084	2.501e-47	175.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7035664_5	234267.Acid_0083	1.781e-87	303.0	COG1502@1|root,COG1502@2|Bacteria,3Y5UA@57723|Acidobacteria	57723|Acidobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD2_k127_7035664_14	234267.Acid_0082	9.875e-25	111.0	2FE51@1|root,3464Y@2|Bacteria,3Y8E0@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7035664_4	234267.Acid_0081	8.384e-95	318.0	COG1409@1|root,COG1409@2|Bacteria,3Y6AF@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_7035664_1	1267535.KB906767_gene656	5.313e-235	737.0	COG1032@1|root,COG1032@2|Bacteria,3Y2FN@57723|Acidobacteria,2JI6W@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_7035664_8	477974.Daud_0086	5.727e-73	264.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,260U4@186807|Peptococcaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HFD2_k127_7035664_13	338963.Pcar_2547	7.248e-28	120.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,42SNI@68525|delta/epsilon subdivisions,2WPFN@28221|Deltaproteobacteria,43SGI@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HFD2_k127_7035664_0	204669.Acid345_0064	5.242e-282	879.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD2_k127_7035664_16	671143.DAMO_2924	1.42e-17	85.0	2CBGA@1|root,33A66@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7035664_15	1382359.JIAL01000001_gene1085	2.119e-21	107.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_7035664_6	1120973.AQXL01000119_gene527	2.236e-82	283.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,4H9SY@91061|Bacilli,277X0@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD2_k127_7035664_2	269799.Gmet_2892	8.706e-107	362.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,43U7K@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HFD2_k127_7035664_12	204669.Acid345_0556	9.838e-30	126.0	COG0816@1|root,COG0816@2|Bacteria,3Y59A@57723|Acidobacteria,2JP2U@204432|Acidobacteriia	204432|Acidobacteriia	J	Likely ribonuclease with RNase H fold.	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD2_k127_7035664_7	1198114.AciX9_3724	5.793e-80	281.0	COG1559@1|root,COG1559@2|Bacteria,3Y2RD@57723|Acidobacteria,2JIQ0@204432|Acidobacteriia	204432|Acidobacteriia	M	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD2_k127_7035664_10	234267.Acid_7919	6.045e-49	186.0	COG2834@1|root,COG2834@2|Bacteria,3Y4A1@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HFD2_k127_7035664_3	204669.Acid345_0559	2.294e-99	338.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,LolA_like,MacB_PCD
HFD2_k127_7035664_9	219305.MCAG_05491	9.823e-68	238.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D8X9@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7037217_36	1266914.ATUK01000014_gene2242	0.0005151	52.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX0E@135613|Chromatiales	135613|Chromatiales	U	PEP-CTERM system TPR-repeat lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_8
HFD2_k127_7037217_27	204669.Acid345_2317	5.213e-24	107.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757,ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Response_reg,SpoIIE
HFD2_k127_7037217_13	639030.JHVA01000001_gene2840	7.146e-83	293.0	COG1524@1|root,COG1524@2|Bacteria,3Y7AY@57723|Acidobacteria,2JKSW@204432|Acidobacteriia	204432|Acidobacteriia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_7037217_1	1267535.KB906767_gene2751	9.43e-232	742.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria,2JHJT@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_0	1267535.KB906767_gene2752	8.226e-254	826.0	COG1629@1|root,COG4771@2|Bacteria,3Y42A@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HFD2_k127_7037217_23	1382359.JIAL01000001_gene1903	4.234e-40	160.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria,2JJ5K@204432|Acidobacteriia	204432|Acidobacteriia	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD2_k127_7037217_29	204669.Acid345_3695	2.511e-21	96.0	2BYAI@1|root,315Y9@2|Bacteria,3Y52S@57723|Acidobacteria,2JJJK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_21	1267535.KB906767_gene290	1.526e-42	171.0	COG2948@1|root,COG2948@2|Bacteria,3Y6SY@57723|Acidobacteria	57723|Acidobacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_19	404589.Anae109_2807	2.232e-55	196.0	COG0346@1|root,COG0346@2|Bacteria,1MZD3@1224|Proteobacteria,434M2@68525|delta/epsilon subdivisions,2X8XQ@28221|Deltaproteobacteria,2Z0XI@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_7037217_15	1278073.MYSTI_03719	4.285e-71	255.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42REB@68525|delta/epsilon subdivisions,2WNWD@28221|Deltaproteobacteria,2YUH8@29|Myxococcales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_7037217_6	1379270.AUXF01000007_gene1000	1.493e-130	428.0	COG1680@1|root,COG1680@2|Bacteria,1ZTI0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_7037217_35	204669.Acid345_3276	4.038e-05	53.0	2EEQA@1|root,338HZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_7	204669.Acid345_3275	1.743e-121	413.0	COG5000@1|root,COG5000@2|Bacteria,3Y32Z@57723|Acidobacteria,2JP5E@204432|Acidobacteriia	204432|Acidobacteriia	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_7037217_3	204669.Acid345_3274	1.275e-165	533.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7037217_31	215803.DB30_0610	3.673e-18	100.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD2_k127_7037217_16	861299.J421_2962	8.279e-70	257.0	COG4191@1|root,COG4191@2|Bacteria,1ZUC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
HFD2_k127_7037217_8	1382359.JIAL01000001_gene613	6.327e-121	417.0	COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria,3Y3Y6@57723|Acidobacteria,2JI5Y@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HFD2_k127_7037217_28	639030.JHVA01000001_gene230	3.284e-23	108.0	COG3170@1|root,COG3170@2|Bacteria,3Y4RX@57723|Acidobacteria,2JJBK@204432|Acidobacteriia	204432|Acidobacteriia	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_4	204669.Acid345_3269	9.066e-154	499.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HZ@57723|Acidobacteria,2JI47@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7037217_14	383372.Rcas_2148	1.258e-74	280.0	COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
HFD2_k127_7037217_34	311424.DhcVS_1396	5.356e-07	55.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,34CNC@301297|Dehalococcoidia	301297|Dehalococcoidia	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS_9,Response_reg
HFD2_k127_7037217_17	570967.JMLV01000012_gene3157	1.925e-68	261.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2JQFN@204441|Rhodospirillales	204441|Rhodospirillales	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HFD2_k127_7037217_33	1192759.AKIB01000065_gene3395	2.746e-07	53.0	2AKNN@1|root,31BF8@2|Bacteria,1Q79W@1224|Proteobacteria,2UXRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_32	525897.Dbac_2184	9.157e-12	67.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,42XTD@68525|delta/epsilon subdivisions,2WT90@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HFD2_k127_7037217_18	404380.Gbem_2014	8.346e-57	204.0	2ADQJ@1|root,313FX@2|Bacteria,1MYNR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_25	404380.Gbem_2013	7.886e-31	128.0	2DQJB@1|root,3377V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_9	234267.Acid_1856	2.759e-120	406.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y45M@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,SpoIIE
HFD2_k127_7037217_5	204669.Acid345_3068	1.218e-141	471.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HFD2_k127_7037217_2	1267535.KB906767_gene5108	1.208e-171	571.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7037217_20	204669.Acid345_4715	2.935e-49	189.0	COG1073@1|root,COG1073@2|Bacteria,3Y5TG@57723|Acidobacteria,2JNP5@204432|Acidobacteriia	204432|Acidobacteriia	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_12	452637.Oter_1529	4.708e-99	337.0	COG1668@1|root,COG1668@2|Bacteria,46VFH@74201|Verrucomicrobia	74201|Verrucomicrobia	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_3
HFD2_k127_7037217_11	452637.Oter_1529	1.961e-106	368.0	COG1668@1|root,COG1668@2|Bacteria,46VFH@74201|Verrucomicrobia	74201|Verrucomicrobia	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_3
HFD2_k127_7037217_10	452637.Oter_1528	7.999e-115	374.0	COG4555@1|root,COG4555@2|Bacteria	2|Bacteria	CP	ABC transporter	natA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02750	ABC_tran
HFD2_k127_7037217_26	411154.GFO_0980	8.017e-26	115.0	COG1917@1|root,COG1917@2|Bacteria,4P2XE@976|Bacteroidetes,1IAY3@117743|Flavobacteriia	976|Bacteroidetes	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7037217_22	1089553.Tph_c13510	6.581e-42	158.0	COG0432@1|root,COG0432@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,42G53@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD2_k127_7037217_24	1279009.ADICEAN_01587	2.862e-34	139.0	COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,47N91@768503|Cytophagia	976|Bacteroidetes	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_7037599_0	234267.Acid_2792	8.316e-64	241.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
HFD2_k127_7043020_0	204669.Acid345_4736	7.547e-179	572.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria,2JHV7@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HFD2_k127_7043020_1	204669.Acid345_2640	1.272e-75	271.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_2,Abhydrolase_4,Esterase
HFD2_k127_7057871_2	1267533.KB906733_gene3589	1.175e-40	159.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_7057871_1	204669.Acid345_1622	1.016e-40	164.0	COG0500@1|root,COG2226@2|Bacteria,3Y5GM@57723|Acidobacteria,2JNQ3@204432|Acidobacteriia	204432|Acidobacteriia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_7057871_0	204669.Acid345_1410	7.21e-67	234.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD2_k127_70757_0	204669.Acid345_1734	1.718e-185	587.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria,2JIIE@204432|Acidobacteriia	57723|Acidobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_70757_1	525904.Tter_2189	1.952e-120	418.0	COG1215@1|root,COG1215@2|Bacteria,2NPD4@2323|unclassified Bacteria	2|Bacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
HFD2_k127_70757_2	443255.SCLAV_5535	1.406e-07	64.0	COG1413@1|root,COG1413@2|Bacteria,2IGUV@201174|Actinobacteria	201174|Actinobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HFD2_k127_7079619_4	204669.Acid345_1211	7.524e-97	326.0	COG0621@1|root,COG0621@2|Bacteria,3Y41R@57723|Acidobacteria,2JKPA@204432|Acidobacteriia	204432|Acidobacteriia	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HFD2_k127_7079619_6	1047013.AQSP01000105_gene1436	1.591e-84	291.0	COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria	2|Bacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HFD2_k127_7079619_1	671143.DAMO_1554	2.115e-127	420.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HFD2_k127_7079619_12	235985.BBPN01000026_gene1442	1.506e-15	82.0	COG0517@1|root,COG0517@2|Bacteria,2HNYW@201174|Actinobacteria,2NJ8T@228398|Streptacidiphilus	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_7079619_7	1123508.JH636441_gene3246	4.551e-55	213.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	PMT_2
HFD2_k127_7079619_14	401053.AciPR4_0575	8.194e-10	63.0	COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7079619_2	1125863.JAFN01000001_gene746	1.879e-110	368.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7079619_8	926692.AZYG01000089_gene1169	8.809e-39	163.0	COG5002@1|root,COG5002@2|Bacteria,1TQV5@1239|Firmicutes,248PK@186801|Clostridia,3WAZH@53433|Halanaerobiales	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
HFD2_k127_7079619_9	504728.K649_08855	5.971e-33	142.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1WITS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HFD2_k127_7079619_10	641524.ADICYQ_4558	1.209e-25	113.0	COG4283@1|root,COG4283@2|Bacteria,4NNFT@976|Bacteroidetes,47QFZ@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1706)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1706
HFD2_k127_7079619_3	269799.Gmet_3036	3.012e-109	370.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43THP@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7079619_5	639030.JHVA01000001_gene3260	1.424e-88	304.0	COG2204@1|root,COG2204@2|Bacteria,3Y4B7@57723|Acidobacteria,2JJ5G@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Sigma54_activat
HFD2_k127_7079619_0	234267.Acid_4657	1.525e-171	602.0	COG5492@1|root,COG5492@2|Bacteria,3Y4WD@57723|Acidobacteria	57723|Acidobacteria	N	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7079619_11	1144275.COCOR_05406	1.076e-19	107.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,DUF3367,DUF4091,DUF4159
HFD2_k127_7086558_5	1133849.O3I_022935	0.0008097	47.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria,4G93C@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7086558_0	204669.Acid345_1918	0.0	1197.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD2_k127_7086558_3	204669.Acid345_3114	4.561e-115	385.0	COG0531@1|root,COG0531@2|Bacteria,3Y3MV@57723|Acidobacteria,2JIZC@204432|Acidobacteriia	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_7086558_1	204669.Acid345_3021	0.0	1188.0	COG4447@1|root,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria	57723|Acidobacteria	M	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_7086558_4	204669.Acid345_3020	9.654e-65	232.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7086558_2	204669.Acid345_2868	1.049e-156	505.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria,2JI17@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_7110271_5	204669.Acid345_0138	9.801e-45	169.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria,2JI9H@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HFD2_k127_7110271_4	278963.ATWD01000001_gene3585	2.389e-46	177.0	COG3468@1|root,COG3468@2|Bacteria,3Y4NE@57723|Acidobacteria,2JJBC@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7110271_3	861299.J421_0149	3.109e-54	199.0	COG0122@1|root,COG0122@2|Bacteria,1ZTST@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD2_k127_7110271_0	204669.Acid345_0136	1.66e-105	350.0	COG1521@1|root,COG1521@2|Bacteria,3Y398@57723|Acidobacteria,2JI76@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HFD2_k127_7110271_1	204669.Acid345_0135	1.306e-94	322.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,3Y4PB@57723|Acidobacteria,2JJAU@204432|Acidobacteriia	204432|Acidobacteriia	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
HFD2_k127_7110271_2	266117.Rxyl_0106	2.311e-56	202.0	COG0157@1|root,COG0157@2|Bacteria,2GV9P@201174|Actinobacteria,4CQ2N@84995|Rubrobacteria	84995|Rubrobacteria	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HFD2_k127_7114773_0	234267.Acid_7167	6.266e-291	910.0	COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria	57723|Acidobacteria	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
HFD2_k127_7114773_2	743719.PaelaDRAFT_2664	2.003e-65	240.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,4HA1H@91061|Bacilli,26S6U@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_7114773_3	330214.NIDE1530	3.195e-41	163.0	COG0515@1|root,COG0515@2|Bacteria	330214.NIDE1530|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HFD2_k127_7114773_1	743721.Psesu_1582	2.678e-98	336.0	2CEN7@1|root,2Z9XA@2|Bacteria,1NQTA@1224|Proteobacteria,1SXXD@1236|Gammaproteobacteria,1X6YN@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7122635_1	1210884.HG799469_gene14187	1.407e-70	243.0	COG0381@1|root,COG0381@2|Bacteria,2IWR6@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD2_k127_7122635_0	1382359.JIAL01000001_gene3047	5.738e-80	278.0	COG4464@1|root,COG4464@2|Bacteria,3Y4AS@57723|Acidobacteria,2JJ14@204432|Acidobacteriia	204432|Acidobacteriia	GM	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD2_k127_7122635_2	102232.GLO73106DRAFT_00009180	8.265e-24	105.0	COG0730@1|root,COG0730@2|Bacteria,1G8K7@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_7129_1	1121920.AUAU01000004_gene789	3.354e-113	380.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria	57723|Acidobacteria	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_7129_0	234267.Acid_0353	1.535e-140	452.0	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_7129_2	1267533.KB906740_gene330	4.629e-94	322.0	COG1071@1|root,COG1071@2|Bacteria,3Y4M3@57723|Acidobacteria	57723|Acidobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD2_k127_7129_3	525904.Tter_0097	6.717e-53	192.0	COG0321@1|root,COG0321@2|Bacteria,2NPE7@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181,2.8.1.8	ko:K03644,ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07767,R07768,R07769	RC00039,RC00992,RC01978,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HFD2_k127_7130012_2	1340493.JNIF01000003_gene4361	1.974e-94	325.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
HFD2_k127_7130012_1	156889.Mmc1_2003	6.411e-101	341.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HFD2_k127_7130012_3	1267535.KB906767_gene2672	8.313e-42	160.0	COG1610@1|root,COG1610@2|Bacteria,3Y4VF@57723|Acidobacteria,2JJJH@204432|Acidobacteriia	204432|Acidobacteriia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HFD2_k127_7130012_0	240015.ACP_2392	1.098e-147	487.0	COG1052@1|root,COG1052@2|Bacteria,3Y2MD@57723|Acidobacteria,2JHYI@204432|Acidobacteriia	204432|Acidobacteriia	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD2_k127_7130012_5	340177.Cag_1756	3.697e-12	68.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_713329_3	204669.Acid345_4221	6.447e-87	301.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria,2JI6I@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_713329_1	671143.DAMO_0515	1.141e-126	423.0	COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD2_k127_713329_7	234267.Acid_7091	1.607e-37	148.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria	57723|Acidobacteria	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD2_k127_713329_9	278963.ATWD01000001_gene3110	4.471e-26	110.0	COG0238@1|root,COG0238@2|Bacteria,3Y53K@57723|Acidobacteria,2JJTE@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD2_k127_713329_8	1340493.JNIF01000004_gene998	1.316e-27	116.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria	57723|Acidobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD2_k127_713329_5	234267.Acid_7094	2.041e-58	209.0	COG0193@1|root,COG0193@2|Bacteria,3Y48V@57723|Acidobacteria	57723|Acidobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD2_k127_713329_4	1267535.KB906767_gene747	2.517e-59	215.0	COG1825@1|root,COG1825@2|Bacteria,3Y41C@57723|Acidobacteria,2JHW5@204432|Acidobacteriia	204432|Acidobacteriia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD2_k127_713329_2	1304880.JAGB01000002_gene2339	2.82e-109	363.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD2_k127_713329_6	234267.Acid_7097	5.715e-57	213.0	COG1947@1|root,COG1947@2|Bacteria,3Y55D@57723|Acidobacteria	57723|Acidobacteria	I	GHMP kinases N terminal domain	-	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_713329_0	204669.Acid345_4603	1.601e-132	444.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HFD2_k127_7198905_6	1306174.JODP01000012_gene6235	8.61e-14	86.0	COG3468@1|root,COG3468@2|Bacteria,2HCJX@201174|Actinobacteria	201174|Actinobacteria	MU	ig-like, plexins, transcription factors	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HFD2_k127_7198905_7	497964.CfE428DRAFT_4830	5.646e-08	64.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	2.4.1.187	ko:K04749,ko:K05946,ko:K06378	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003,ko03021	-	GT26	-	STAS,STAS_2
HFD2_k127_7198905_8	28115.HR11_05190	9.213e-06	52.0	COG4758@1|root,COG4758@2|Bacteria,4NQRE@976|Bacteroidetes,2FMXH@200643|Bacteroidia	976|Bacteroidetes	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
HFD2_k127_7198905_4	264732.Moth_0417	2.95e-59	214.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	kdgR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_7198905_0	204669.Acid345_4707	3.217e-221	698.0	COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria,2JKQY@204432|Acidobacteriia	204432|Acidobacteriia	C	Malate synthase	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HFD2_k127_7198905_1	234267.Acid_5701	7.892e-197	624.0	COG2224@1|root,COG2224@2|Bacteria,3Y345@57723|Acidobacteria	57723|Acidobacteria	C	Isocitrate lyase family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HFD2_k127_7198905_5	290397.Adeh_0191	2.847e-43	163.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42SK2@68525|delta/epsilon subdivisions,2WPB3@28221|Deltaproteobacteria,2Z0CU@29|Myxococcales	28221|Deltaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_7198905_2	215803.DB30_1529	1.219e-169	546.0	COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,433AE@68525|delta/epsilon subdivisions,2WYFQ@28221|Deltaproteobacteria,2YY3M@29|Myxococcales	28221|Deltaproteobacteria	S	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
HFD2_k127_7198905_3	1297742.A176_06097	1.925e-75	259.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD2_k127_7230477_1	1267535.KB906767_gene820	4.577e-124	402.0	COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD2_k127_7230477_2	234267.Acid_0291	9.105e-117	395.0	COG1167@1|root,COG1167@2|Bacteria,3Y4RE@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD2_k127_7230477_0	1382306.JNIM01000001_gene3484	1.094e-142	469.0	COG0365@1|root,COG0365@2|Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	badA	-	6.2.1.25,6.2.1.27	ko:K04105,ko:K04110	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R01300,R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7241756_5	1111479.AXAR01000021_gene1077	1.333e-33	135.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,278F5@186823|Alicyclobacillaceae	91061|Bacilli	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HFD2_k127_7241756_3	1300345.LF41_48	6.817e-55	222.0	COG0028@1|root,COG1520@1|root,COG3391@1|root,COG3693@1|root,COG0028@2|Bacteria,COG1520@2|Bacteria,COG3391@2|Bacteria,COG3693@2|Bacteria,1QYUP@1224|Proteobacteria	1224|Proteobacteria	EH	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR
HFD2_k127_7241756_0	247490.KSU1_C0714	6.336e-172	588.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HFD2_k127_7241756_6	1144305.PMI02_01735	3.636e-14	85.0	COG0457@1|root,COG0457@2|Bacteria,1R20U@1224|Proteobacteria,2U3F2@28211|Alphaproteobacteria,2K34W@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_7241756_2	1267533.KB906735_gene4718	2.272e-61	220.0	COG0164@1|root,COG0164@2|Bacteria,3Y49K@57723|Acidobacteria,2JJ4J@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HFD2_k127_7241756_1	204669.Acid345_4380	7.632e-88	321.0	COG0457@1|root,COG2956@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,3Y89N@57723|Acidobacteria	57723|Acidobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HFD2_k127_7241756_7	278963.ATWD01000001_gene3013	4.1e-12	70.0	2EE2J@1|root,337X9@2|Bacteria,3Y5PQ@57723|Acidobacteria,2JJZA@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7241756_4	290512.Paes_1006	4.221e-34	140.0	COG0352@1|root,COG0352@2|Bacteria,1FE4T@1090|Chlorobi	1090|Chlorobi	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD2_k127_7246579_1	204669.Acid345_3340	9.044e-105	351.0	COG0550@1|root,COG0550@2|Bacteria,3Y343@57723|Acidobacteria,2JHPW@204432|Acidobacteriia	204432|Acidobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HFD2_k127_7246579_0	639030.JHVA01000001_gene3564	1.889e-113	377.0	COG0758@1|root,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria,2JI6N@204432|Acidobacteriia	204432|Acidobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD2_k127_7247045_5	234267.Acid_0700	6.303e-13	70.0	COG0577@1|root,COG0577@2|Bacteria,3Y321@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7247045_3	234267.Acid_6599	1.026e-207	674.0	COG0577@1|root,COG0577@2|Bacteria,3Y7DQ@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7247045_0	240015.ACP_3514	5.795e-262	829.0	COG0577@1|root,COG0577@2|Bacteria,3Y6R1@57723|Acidobacteria,2JMKX@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7247045_2	1183438.GKIL_4354	7.201e-210	677.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7247045_1	234267.Acid_3798	7.961e-217	700.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_3798|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7247045_4	204669.Acid345_3459	5.194e-44	166.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_7314041_0	1379270.AUXF01000003_gene3608	0.0	1515.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HFD2_k127_7314041_1	682795.AciX8_0001	6.055e-42	156.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria,2JHN7@204432|Acidobacteriia	204432|Acidobacteriia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD2_k127_7321167_0	404589.Anae109_1395	6.849e-31	138.0	COG1572@1|root,COG1572@2|Bacteria,1N4MI@1224|Proteobacteria,42USE@68525|delta/epsilon subdivisions,2WQX2@28221|Deltaproteobacteria,2YVY2@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4091)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4091
HFD2_k127_733343_3	234267.Acid_6487	1.58e-51	198.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K02005,ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD2_k127_733343_2	1340493.JNIF01000003_gene2327	1.057e-71	259.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
HFD2_k127_733343_1	1267535.KB906767_gene2303	2.464e-73	264.0	COG0845@1|root,COG0845@2|Bacteria,3Y6E7@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_733343_0	234267.Acid_6484	1.006e-146	479.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_733343_4	1340493.JNIF01000003_gene2324	3.018e-33	138.0	COG1538@1|root,COG1538@2|Bacteria,3Y7Q2@57723|Acidobacteria	57723|Acidobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_7362749_1	204669.Acid345_4631	2.064e-164	529.0	COG0577@1|root,COG0577@2|Bacteria,3Y3X9@57723|Acidobacteria,2JHKJ@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7362749_0	204669.Acid345_4630	1.082e-176	562.0	COG0577@1|root,COG0577@2|Bacteria,3Y2IG@57723|Acidobacteria,2JHUY@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7362749_2	234267.Acid_0099	2.581e-86	298.0	2EBMM@1|root,335MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7367857_2	309801.trd_1049	1.917e-115	387.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi,27Z2G@189775|Thermomicrobia	189775|Thermomicrobia	E	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
HFD2_k127_7367857_1	279714.FuraDRAFT_2563	2.352e-141	463.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1MUBE@1224|Proteobacteria,2VPRG@28216|Betaproteobacteria,2KSUP@206351|Neisseriales	206351|Neisseriales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HFD2_k127_7367857_3	1161401.ASJA01000009_gene1791	5.702e-94	319.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,DUF305,Lactonase
HFD2_k127_7367857_4	880073.Calab_0632	2.313e-91	316.0	COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria	2|Bacteria	E	Amino acid kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	AA_kinase
HFD2_k127_7367857_5	1121439.dsat_2228	6.226e-90	311.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WPYW@28221|Deltaproteobacteria,2MC7X@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_7367857_0	880073.Calab_3230	5.35e-149	477.0	COG0078@1|root,COG0078@2|Bacteria,2NPA3@2323|unclassified Bacteria	2|Bacteria	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_7367857_6	938278.CAJO01000087_gene1445	6.963e-08	55.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,267KB@186813|unclassified Clostridiales	186801|Clostridia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_7370724_0	234267.Acid_7310	1.858e-160	517.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7370724_1	204669.Acid345_3629	4.132e-87	299.0	COG0707@1|root,COG0707@2|Bacteria,3Y48B@57723|Acidobacteria,2JIYA@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD2_k127_7370724_2	204669.Acid345_3630	2.928e-72	252.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_7388660_4	1122134.KB893651_gene2412	1.138e-05	54.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIG8@135619|Oceanospirillales	135619|Oceanospirillales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7388660_2	234267.Acid_7679	2.845e-58	221.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_7388660_1	1382359.JIAL01000001_gene577	1.962e-276	863.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_7388660_3	243231.GSU1945	4.881e-08	66.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
HFD2_k127_7388660_0	1382359.JIAL01000001_gene844	2.52e-303	947.0	COG0567@1|root,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria,2JICX@204432|Acidobacteriia	204432|Acidobacteriia	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoGdeHyase_C,Transket_pyr
HFD2_k127_738976_3	1382359.JIAL01000001_gene1699	2.124e-64	223.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria,2JI2K@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD2_k127_738976_10	234267.Acid_5114	1.146e-41	157.0	COG0185@1|root,COG0185@2|Bacteria,3Y560@57723|Acidobacteria	57723|Acidobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD2_k127_738976_12	234267.Acid_5113	3.493e-34	137.0	COG0091@1|root,COG0091@2|Bacteria,3Y4KH@57723|Acidobacteria	57723|Acidobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD2_k127_738976_1	204669.Acid345_1232	1.003e-99	334.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria,2JIRU@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD2_k127_738976_4	1267535.KB906767_gene2697	8.163e-63	218.0	COG0197@1|root,COG0197@2|Bacteria,3Y4EG@57723|Acidobacteria	57723|Acidobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HFD2_k127_738976_17	1340493.JNIF01000003_gene3215	6.023e-07	54.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HFD2_k127_738976_14	1340493.JNIF01000003_gene3216	4.719e-23	101.0	COG0186@1|root,COG0186@2|Bacteria,3Y5I3@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HFD2_k127_738976_7	240015.ACP_1441	2.636e-54	192.0	COG0093@1|root,COG0093@2|Bacteria,3Y4N0@57723|Acidobacteria,2JJ86@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HFD2_k127_738976_13	234267.Acid_5107	1.136e-30	128.0	COG0198@1|root,COG0198@2|Bacteria,3Y56T@57723|Acidobacteria	57723|Acidobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HFD2_k127_738976_2	1267535.KB906767_gene2692	3.29e-76	259.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HFD2_k127_738976_15	1379698.RBG1_1C00001G1583	3.599e-19	89.0	COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria	2|Bacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HFD2_k127_738976_9	1340493.JNIF01000003_gene3221	2.528e-48	176.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HFD2_k127_738976_6	234267.Acid_5103	1.511e-60	214.0	COG0097@1|root,COG0097@2|Bacteria,3Y496@57723|Acidobacteria	57723|Acidobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HFD2_k127_738976_11	926692.AZYG01000040_gene1579	1.592e-36	143.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3WBWI@53433|Halanaerobiales	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD2_k127_738976_5	1345697.M493_00960	2.904e-61	215.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,4HFN4@91061|Bacilli,1WEPH@129337|Geobacillus	91061|Bacilli	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HFD2_k127_738976_16	479434.Sthe_1054	3.464e-12	70.0	COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi,27YRK@189775|Thermomicrobia	189775|Thermomicrobia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HFD2_k127_738976_8	986075.CathTA2_2514	2.018e-50	183.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD2_k127_738976_0	234267.Acid_5098	2.331e-167	536.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD2_k127_739711_6	1380394.JADL01000010_gene4202	1.748e-08	66.0	COG2040@1|root,COG2040@2|Bacteria,1QU2A@1224|Proteobacteria,2TS3P@28211|Alphaproteobacteria,2JQ6P@204441|Rhodospirillales	204441|Rhodospirillales	E	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD2_k127_739711_3	410359.Pcal_0041	2.753e-36	151.0	COG0524@1|root,arCOG00014@2157|Archaea,2XQ77@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM PfkB domain protein	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_739711_1	357808.RoseRS_0541	3.835e-120	392.0	COG0434@1|root,COG0434@2|Bacteria,2G6UF@200795|Chloroflexi,376AD@32061|Chloroflexia	32061|Chloroflexia	S	PFAM photosystem I assembly BtpA	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
HFD2_k127_739711_5	204669.Acid345_1676	1.711e-24	109.0	2FJ4P@1|root,34AUY@2|Bacteria,3Y8PT@57723|Acidobacteria,2JNJ3@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_739711_4	204669.Acid345_1675	1.491e-32	130.0	COG1225@1|root,COG1225@2|Bacteria,3Y8D4@57723|Acidobacteria,2JNH4@204432|Acidobacteriia	204432|Acidobacteriia	O	Iodothyronine deiodinase	-	-	-	-	-	-	-	-	-	-	-	-	T4_deiodinase
HFD2_k127_739711_0	204669.Acid345_1682	1.5e-323	1026.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria,2JKNM@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,UnbV_ASPIC,VCBS
HFD2_k127_739711_2	204669.Acid345_1684	1.91e-46	170.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD2_k127_7406565_2	204669.Acid345_2250	4.344e-145	469.0	COG0029@1|root,COG0029@2|Bacteria,3Y39F@57723|Acidobacteria,2JHJ5@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_7406565_3	401053.AciPR4_0607	1.617e-96	327.0	COG0337@1|root,COG0337@2|Bacteria,3Y2T4@57723|Acidobacteria,2JI0C@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HFD2_k127_7406565_0	869210.Marky_0038	2.539e-225	709.0	COG0318@1|root,COG0318@2|Bacteria,1WIB8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7406565_4	234267.Acid_7345	1.666e-69	244.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_7406565_1	204669.Acid345_1588	2.88e-168	542.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JKV3@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7406565_6	204669.Acid345_1590	4.228e-62	232.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02668,ko:K07708	ko02020,map02020	M00497,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,RsbRD_N
HFD2_k127_7406565_5	234267.Acid_5172	1.655e-62	224.0	COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria	57723|Acidobacteria	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD2_k127_7411788_5	1444309.JAQG01000037_gene2805	1.192e-09	67.0	COG2318@1|root,COG2318@2|Bacteria,1V8HE@1239|Firmicutes,4HJ3X@91061|Bacilli,272R9@186822|Paenibacillaceae	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HFD2_k127_7411788_7	1123371.ATXH01000006_gene834	7.675e-05	52.0	COG3215@1|root,COG3215@2|Bacteria,2GIKF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HFD2_k127_7411788_6	1121896.JMLU01000018_gene2850	7.814e-06	57.0	2BUNJ@1|root,32PZE@2|Bacteria,4NQFC@976|Bacteroidetes,1IBK9@117743|Flavobacteriia,2NZTH@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7411788_0	525904.Tter_0593	2.886e-93	321.0	COG1252@1|root,COG1252@2|Bacteria,2NP3T@2323|unclassified Bacteria	2|Bacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885,ko:K15977	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_7411788_1	1385517.N800_10350	2.712e-86	315.0	COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,1RZDP@1236|Gammaproteobacteria,1X5SC@135614|Xanthomonadales	135614|Xanthomonadales	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_7411788_3	234267.Acid_1443	5.885e-79	295.0	COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	HEAT_2,NB-ARC,TLC,cNMP_binding
HFD2_k127_7411788_2	234267.Acid_5004	2.972e-82	283.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_7411788_4	234267.Acid_5004	1.055e-23	104.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_7413167_10	517418.Ctha_1311	1.454e-11	72.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1FD7Y@1090|Chlorobi	1090|Chlorobi	K	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TIR_2,TPR_12,TPR_7
HFD2_k127_7413167_8	471853.Bcav_0186	5.481e-42	161.0	2CEIY@1|root,348HS@2|Bacteria,2H8Z7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_7413167_2	1088721.NSU_2683	3.51e-105	357.0	COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria,2K2GC@204457|Sphingomonadales	204457|Sphingomonadales	Q	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
HFD2_k127_7413167_7	868595.Desca_1429	1.42e-44	171.0	COG1216@1|root,COG1216@2|Bacteria,1UN4Z@1239|Firmicutes,25GWH@186801|Clostridia	186801|Clostridia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_7413167_9	1192034.CAP_7694	9.171e-35	149.0	COG0451@1|root,COG0451@2|Bacteria,1RBIE@1224|Proteobacteria,42QDU@68525|delta/epsilon subdivisions,2WJD4@28221|Deltaproteobacteria,2Z21Q@29|Myxococcales	28221|Deltaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	1.1.1.339	ko:K19180	ko00523,ko01130,map00523,map01130	-	R10190	RC00182	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD2_k127_7413167_1	118168.MC7420_5158	3.203e-127	415.0	COG0451@1|root,COG0451@2|Bacteria,1G2VR@1117|Cyanobacteria,1H9RF@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_7413167_4	459495.SPLC1_S140020	5.548e-83	284.0	COG1208@1|root,COG1208@2|Bacteria,1G00Y@1117|Cyanobacteria,1H74C@1150|Oscillatoriales	1117|Cyanobacteria	JM	Glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HFD2_k127_7413167_6	1469613.JT55_10590	1.01e-61	237.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7413167_0	1499967.BAYZ01000195_gene3101	2.785e-129	422.0	COG0451@1|root,COG0451@2|Bacteria,2NP15@2323|unclassified Bacteria	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	arnA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315	1.1.1.305,2.1.2.13,5.1.3.2	ko:K01784,ko:K10011,ko:K12449	ko00052,ko00520,ko01100,ko01503,map00052,map00520,map01100,map01503	M00361,M00362,M00632,M00721,M00761	R00291,R01384,R01386,R02984,R07658,R07660	RC00026,RC00289,RC00508,RC01575,RC01811,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO2420,iSFV_1184.SFV_2325	Epimerase,Formyl_trans_C,Formyl_trans_N,GDP_Man_Dehyd
HFD2_k127_7413167_3	313612.L8106_11627	1.177e-84	293.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria,1H8A8@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_7413167_5	1198232.CYCME_1451	8.319e-77	271.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,1RYRV@1236|Gammaproteobacteria,4612P@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_7421350_2	204669.Acid345_4634	8.845e-66	235.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HFD2_k127_7421350_1	1123393.KB891316_gene1226	1.361e-91	307.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VRSR@28216|Betaproteobacteria,1KSTT@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Predicted membrane protein (DUF2238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2238
HFD2_k127_7421350_0	251221.35211765	1.373e-193	634.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_742217_0	204669.Acid345_1683	3.338e-167	537.0	COG0457@1|root,COG0457@2|Bacteria,3Y2Q7@57723|Acidobacteria,2JIH1@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_11,TPR_16,TPR_2,TPR_8
HFD2_k127_742217_1	1267534.KB906754_gene2899	1.278e-77	267.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria,2JKKU@204432|Acidobacteriia	204432|Acidobacteriia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_742644_17	240015.ACP_0085	1.315e-07	56.0	COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria,2JKD3@204432|Acidobacteriia	204432|Acidobacteriia	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase
HFD2_k127_742644_15	754027.HMPREF9554_02000	1.531e-11	76.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD2_k127_742644_0	671143.DAMO_1991	1.351e-234	740.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HFD2_k127_742644_14	1267533.KB906733_gene3212	2.625e-22	99.0	COG1828@1|root,COG1828@2|Bacteria,3Y5NE@57723|Acidobacteria,2JJWM@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HFD2_k127_742644_6	204669.Acid345_0045	3.273e-73	259.0	COG1816@1|root,COG1816@2|Bacteria,3Y2R0@57723|Acidobacteria,2JINF@204432|Acidobacteriia	204432|Acidobacteriia	F	Adenosine/AMP deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HFD2_k127_742644_12	743722.Sph21_3960	1.572e-34	144.0	28JI8@1|root,2Z9BM@2|Bacteria,4NE5E@976|Bacteroidetes,1IPV1@117747|Sphingobacteriia	976|Bacteroidetes	S	S1 P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease,Zn_dep_PLPC
HFD2_k127_742644_2	234267.Acid_1175	1.268e-202	643.0	COG0531@1|root,COG0531@2|Bacteria,3Y2R3@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD2_k127_742644_1	1382359.JIAL01000001_gene1484	8.265e-203	655.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_742644_18	234267.Acid_6496	0.0006451	50.0	2B707@1|root,3200P@2|Bacteria,3Y4XV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_742644_4	639030.JHVA01000001_gene1578	2.704e-84	296.0	COG1519@1|root,COG1519@2|Bacteria,3Y3X5@57723|Acidobacteria,2JI61@204432|Acidobacteriia	204432|Acidobacteriia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HFD2_k127_742644_10	1267535.KB906767_gene1430	2.449e-54	205.0	COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,3Y3X5@57723|Acidobacteria,2JI61@204432|Acidobacteriia	204432|Acidobacteriia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HFD2_k127_742644_5	234267.Acid_6381	1.014e-80	284.0	COG0859@1|root,COG0859@2|Bacteria,3Y6NF@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_742644_9	880072.Desac_0949	8.798e-55	198.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,2MQQI@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HFD2_k127_742644_7	290397.Adeh_2611	1.762e-71	254.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
HFD2_k127_742644_11	1047013.AQSP01000111_gene1673	8.476e-43	168.0	COG0615@1|root,COG0615@2|Bacteria,2NPMA@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.39,2.7.7.70	ko:K00980,ko:K03272	ko00540,ko00564,ko01100,map00540,map00564,map01100	M00064	R00856,R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CN_hydrolase,CTP_transf_like,PfkB
HFD2_k127_742644_8	204669.Acid345_4721	4.699e-57	215.0	COG0859@1|root,COG0859@2|Bacteria,3Y3EJ@57723|Acidobacteria,2JIYJ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_742644_13	204669.Acid345_4722	1.088e-31	134.0	COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria,2JJJZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_742644_16	335543.Sfum_3248	3.699e-10	68.0	2EQZT@1|root,33IJD@2|Bacteria,1NKTX@1224|Proteobacteria,42XNG@68525|delta/epsilon subdivisions,2WTCK@28221|Deltaproteobacteria,2MQPM@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_742644_3	204669.Acid345_0140	6.388e-119	414.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria,2JI41@204432|Acidobacteriia	204432|Acidobacteriia	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HFD2_k127_7427220_2	1382359.JIAL01000001_gene1556	7.851e-22	95.0	COG0192@1|root,COG0192@2|Bacteria,3Y45C@57723|Acidobacteria,2JJ0A@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_7427220_0	240015.ACP_2455	8.13e-207	649.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HFD2_k127_7427220_1	765420.OSCT_1317	6.778e-62	222.0	28Q3B@1|root,2ZCKZ@2|Bacteria,2G8QN@200795|Chloroflexi,376RR@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7427220_3	204669.Acid345_3767	1.899e-14	75.0	COG0312@1|root,COG0312@2|Bacteria,3Y6TF@57723|Acidobacteria	57723|Acidobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_7473874_2	266117.Rxyl_0137	7.551e-42	168.0	COG0449@1|root,COG0449@2|Bacteria,2IIQ7@201174|Actinobacteria,4CQF9@84995|Rubrobacteria	84995|Rubrobacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	-
HFD2_k127_7473874_1	247490.KSU1_B0316	1.186e-67	239.0	COG2518@1|root,COG2518@2|Bacteria,2IX21@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_7473874_0	234267.Acid_3593	1.084e-70	264.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_7473874_3	234267.Acid_6263	3.472e-12	76.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_7477735_0	1499967.BAYZ01000194_gene3127	2.899e-70	245.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD2_k127_7477735_2	1382359.JIAL01000001_gene753	1.096e-08	65.0	COG2823@1|root,COG2823@2|Bacteria,3Y99E@57723|Acidobacteria,2JP08@204432|Acidobacteriia	204432|Acidobacteriia	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7477735_1	880072.Desac_2446	6.343e-19	87.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MQ7N@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HFD2_k127_7506946_1	448385.sce0497	1.424e-34	140.0	COG2040@1|root,COG2040@2|Bacteria,1Q99A@1224|Proteobacteria,43DPD@68525|delta/epsilon subdivisions,2WZAC@28221|Deltaproteobacteria,2Z1PN@29|Myxococcales	28221|Deltaproteobacteria	H	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
HFD2_k127_7506946_0	530564.Psta_1177	1.572e-45	177.0	COG2040@1|root,COG2040@2|Bacteria,2J3GR@203682|Planctomycetes	203682|Planctomycetes	H	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD2_k127_7530581_1	113395.AXAI01000010_gene2102	3.413e-78	269.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3JRYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	MA20_20675	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_7530581_3	240015.ACP_1775	1.434e-21	105.0	2BRBT@1|root,32KAC@2|Bacteria,3Y4TB@57723|Acidobacteria,2JJHG@204432|Acidobacteriia	204432|Acidobacteriia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HFD2_k127_7530581_0	204669.Acid345_0144	2.521e-134	438.0	COG0343@1|root,COG0343@2|Bacteria,3Y3CP@57723|Acidobacteria,2JISV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD2_k127_7530581_5	1120980.JQKH01000056_gene1151	4.624e-07	60.0	2ANVJ@1|root,33KYN@2|Bacteria,1NRDZ@1224|Proteobacteria,2VZFD@28216|Betaproteobacteria,2KSI9@206351|Neisseriales	206351|Neisseriales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7530581_4	1499967.BAYZ01000074_gene2162	2.405e-19	92.0	COG1862@1|root,COG1862@2|Bacteria,2NPY3@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase, YajC	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD2_k127_7530581_2	682795.AciX8_4405	2.579e-44	171.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria,2JHJC@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD2_k127_7546864_3	1267535.KB906767_gene195	1.372e-31	126.0	COG0443@1|root,COG0443@2|Bacteria,3Y2F8@57723|Acidobacteria,2JIVF@204432|Acidobacteriia	204432|Acidobacteriia	O	heat shock protein 70	-	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
HFD2_k127_7546864_1	204669.Acid345_0481	1.387e-46	179.0	COG1076@1|root,COG1076@2|Bacteria,3Y4MR@57723|Acidobacteria,2JJBF@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM heat shock protein DnaJ	-	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
HFD2_k127_7546864_2	1382359.JIAL01000001_gene823	5.799e-41	153.0	COG0316@1|root,COG0316@2|Bacteria,3Y518@57723|Acidobacteria,2JJGN@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD2_k127_7546864_0	1382359.JIAL01000001_gene822	1.665e-47	171.0	COG0822@1|root,COG0822@2|Bacteria,3Y4B9@57723|Acidobacteria,2JJ45@204432|Acidobacteriia	204432|Acidobacteriia	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_7561560_0	1267533.KB906738_gene2029	2.268e-297	933.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_7561560_1	1267533.KB906738_gene2028	1.533e-166	529.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
HFD2_k127_7565859_0	671143.DAMO_0738	0.0	1032.0	COG0058@1|root,COG0058@2|Bacteria,2NP1W@2323|unclassified Bacteria	2|Bacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HFD2_k127_7565859_1	234267.Acid_3945	2.553e-224	703.0	COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD2_k127_756693_0	1183438.GKIL_4354	1.04e-164	546.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_756693_1	234267.Acid_3798	1.134e-157	526.0	COG0577@1|root,COG0577@2|Bacteria	234267.Acid_3798|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_756693_2	1267535.KB906767_gene632	7.113e-116	381.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_756693_4	671143.DAMO_1259	4.859e-32	134.0	COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	MA20_16815	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_756693_3	243231.GSU1610	1.907e-107	365.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_7569777_1	886293.Sinac_2707	3.276e-15	79.0	COG1215@1|root,COG1215@2|Bacteria,2J0YZ@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_7569777_0	886293.Sinac_2707	2.363e-36	150.0	COG1215@1|root,COG1215@2|Bacteria,2J0YZ@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_7575348_1	1267535.KB906767_gene4160	3.466e-41	166.0	COG2304@1|root,COG2304@2|Bacteria,3Y99W@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_7575348_0	204669.Acid345_4407	6.857e-82	282.0	COG1611@1|root,COG1611@2|Bacteria,3Y2MR@57723|Acidobacteria,2JHUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD2_k127_7575348_2	251229.Chro_2813	7.979e-09	64.0	COG2972@1|root,COG4251@1|root,COG2972@2|Bacteria,COG4251@2|Bacteria,1GQDH@1117|Cyanobacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	yclK	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023051,GO:0023052,GO:0023057,GO:0035556,GO:0036211,GO:0042802,GO:0042803,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046983,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070297,GO:0070298,GO:0071704,GO:0140096,GO:1901564,GO:1902531,GO:1902532	2.7.13.3	ko:K02484,ko:K02660,ko:K07653,ko:K07654,ko:K11617	ko02020,ko02025,map02020,map02025	M00460,M00461,M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_7621363_2	234267.Acid_1586	9.561e-62	218.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096,ko:K07496	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
HFD2_k127_7621363_3	1123367.C666_11020	6.026e-23	112.0	COG1988@1|root,COG1988@2|Bacteria,1R5QP@1224|Proteobacteria,2WFIE@28216|Betaproteobacteria,2KVF6@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane-bound metal-dependent	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HFD2_k127_7621363_0	204669.Acid345_0099	3.473e-109	363.0	COG0709@1|root,COG0709@2|Bacteria,3Y6V3@57723|Acidobacteria,2JM9D@204432|Acidobacteriia	204432|Acidobacteriia	E	AIR synthase related protein, C-terminal domain	-	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HFD2_k127_7621363_1	682795.AciX8_0163	1.953e-96	329.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7628686_1	204669.Acid345_2141	1.457e-97	323.0	COG2133@1|root,COG2133@2|Bacteria,3Y98P@57723|Acidobacteria,2JP56@204432|Acidobacteriia	204432|Acidobacteriia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7628686_0	234267.Acid_0570	3.56e-322	1013.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria	57723|Acidobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,PDZ,Peptidase_S41,Tricorn_C1
HFD2_k127_7631769_1	204669.Acid345_4424	2.929e-80	272.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_7631769_3	1121468.AUBR01000007_gene253	1.068e-43	170.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,42G1K@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HFD2_k127_7631769_0	671143.DAMO_0007	2.256e-91	314.0	COG0265@1|root,COG0265@2|Bacteria,2NQPN@2323|unclassified Bacteria	2|Bacteria	O	Trypsin	degP	-	1.3.1.74	ko:K08070,ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_7631769_4	525904.Tter_1706	1.107e-10	68.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_7631769_2	472759.Nhal_2071	6.571e-47	183.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1SEZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HFD2_k127_7640440_1	1122137.AQXF01000003_gene2417	1.491e-93	317.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_7640440_0	1121920.AUAU01000004_gene814	3.144e-130	431.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
HFD2_k127_7640440_3	234267.Acid_5258	1.058e-22	102.0	COG2010@1|root,COG2010@2|Bacteria,3Y5PY@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_7640440_4	1157638.KB892187_gene5679	1.466e-18	96.0	COG1028@1|root,COG1028@2|Bacteria,2GJIH@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7640440_2	401053.AciPR4_4162	1.158e-23	102.0	COG0776@1|root,COG0776@2|Bacteria,3Y50P@57723|Acidobacteria,2JJJ5@204432|Acidobacteriia	204432|Acidobacteriia	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_7653295_0	1173024.KI912149_gene5493	2.95e-202	638.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1JK2F@1189|Stigonemataceae	1117|Cyanobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD2_k127_7653295_1	251221.35211731	6.14e-170	542.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HFD2_k127_7657201_1	234267.Acid_6681	4.139e-65	224.0	COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HFD2_k127_7657201_2	1410616.JHXE01000008_gene1314	5.495e-05	48.0	COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,24BH8@186801|Clostridia	186801|Clostridia	S	Tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HFD2_k127_7657201_0	861299.J421_0786	6.642e-146	477.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZT4G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_7668061_6	767434.Fraau_0383	2.323e-26	117.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1X38K@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD2_k127_7668061_1	204669.Acid345_3349	7.213e-181	578.0	COG0297@1|root,COG0297@2|Bacteria,3Y3IH@57723|Acidobacteria,2JHNU@204432|Acidobacteriia	204432|Acidobacteriia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD2_k127_7668061_5	1487953.JMKF01000080_gene4196	2.35e-32	132.0	COG3118@1|root,COG3118@2|Bacteria,1G6KZ@1117|Cyanobacteria,1HBSI@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HFD2_k127_7668061_0	404589.Anae109_0490	1.524e-182	580.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,42Z8C@68525|delta/epsilon subdivisions,2WU08@28221|Deltaproteobacteria,2YXJP@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7668061_2	1267535.KB906767_gene1736	2.893e-146	475.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria,2JIIV@204432|Acidobacteriia	204432|Acidobacteriia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD2_k127_7668061_3	204669.Acid345_4646	5.697e-110	370.0	COG0303@1|root,COG0303@2|Bacteria,3Y3F0@57723|Acidobacteria,2JICE@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD2_k127_7668061_7	999541.bgla_2g13410	3.842e-10	66.0	COG3755@1|root,COG3755@2|Bacteria,1N9U0@1224|Proteobacteria,2VW9N@28216|Betaproteobacteria,1KHJ3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pfam:DUF1311	-	-	-	-	-	-	-	-	-	-	-	-	LprI
HFD2_k127_7668061_4	1267535.KB906767_gene4602	5.535e-53	190.0	COG0315@1|root,COG0315@2|Bacteria,3Y4IY@57723|Acidobacteria,2JJ7K@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HFD2_k127_7671823_10	96561.Dole_2625	4.086e-37	141.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MJG6@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HFD2_k127_7671823_11	204669.Acid345_4440	3.999e-13	71.0	29WS1@1|root,30ID4@2|Bacteria,3Y5IE@57723|Acidobacteria,2JK0W@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HFD2_k127_7671823_5	204669.Acid345_0279	1.215e-113	381.0	COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria,2JIQN@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD2_k127_7671823_0	1123368.AUIS01000017_gene2575	2e-253	794.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,2NBQZ@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD2_k127_7671823_9	118166.JH976537_gene4851	6.229e-39	151.0	COG2323@1|root,COG2323@2|Bacteria,1G5E3@1117|Cyanobacteria,1HD86@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HFD2_k127_7671823_7	234267.Acid_1401	5.506e-47	175.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_7671823_3	42256.RradSPS_2906	2.23e-125	421.0	COG2898@1|root,COG2898@2|Bacteria,2I2ZR@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised conserved protein (DUF2156)	lysX	-	2.3.2.3,6.1.1.6	ko:K04567,ko:K14205	ko00970,ko01503,ko02020,ko05150,map00970,map01503,map02020,map05150	M00359,M00360,M00726	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko01504,ko03016	2.A.1.3.37	-	-	DUF2156,tRNA-synt_2_TM
HFD2_k127_7671823_12	1121288.AULL01000015_gene141	1.012e-08	66.0	COG3946@1|root,COG3946@2|Bacteria,4NSWS@976|Bacteroidetes,1IIET@117743|Flavobacteriia	976|Bacteroidetes	U	Bacterial virulence protein (VirJ)	-	-	-	-	-	-	-	-	-	-	-	-	VirJ
HFD2_k127_7671823_8	234267.Acid_5547	8.178e-47	182.0	COG0392@1|root,COG0392@2|Bacteria,3Y7S6@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HFD2_k127_7671823_1	204669.Acid345_0583	5.812e-136	466.0	COG0457@1|root,COG2199@1|root,COG2203@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	MA20_13010	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HisKA,Lactamase_B_2,PAS_4
HFD2_k127_7671823_2	246197.MXAN_5883	2.984e-134	438.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WMIY@28221|Deltaproteobacteria,2YUCQ@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.16	ko:K07508	ko00062,ko00071,ko00280,ko01100,ko01110,ko01130,ko01212,map00062,map00071,map00280,map01100,map01110,map01130,map01212	M00085,M00087	R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_7671823_4	204669.Acid345_1212	9.365e-125	406.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_7671823_6	1297570.MESS4_790094	1.804e-47	175.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,43IN0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_7677361_1	1267535.KB906767_gene4268	7.753e-19	93.0	COG3503@1|root,COG3503@2|Bacteria,3Y73K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD2_k127_7677361_3	1267534.KB906755_gene3926	3.136e-08	64.0	COG2919@1|root,COG2919@2|Bacteria,3Y53U@57723|Acidobacteria,2JJPX@204432|Acidobacteriia	204432|Acidobacteriia	D	PFAM Septum formation initiator	-	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HFD2_k127_7677361_0	1382359.JIAL01000001_gene2262	2.079e-149	486.0	COG1109@1|root,COG1109@2|Bacteria,3Y2Y6@57723|Acidobacteria,2JHZU@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_7677361_2	1267535.KB906767_gene4225	7.216e-18	86.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD2_k127_7678358_0	234267.Acid_0690	2.239e-208	673.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria	57723|Acidobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD2_k127_7678358_1	234267.Acid_3706	2.186e-29	123.0	2DTT4@1|root,33MIX@2|Bacteria,3Y951@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7679932_3	234267.Acid_4549	1.106e-38	151.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7679932_1	204669.Acid345_1001	5.093e-95	318.0	COG3279@1|root,COG3279@2|Bacteria,3Y3HR@57723|Acidobacteria,2JIXA@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component transcriptional regulator, LytTR family	-	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_7679932_0	204669.Acid345_0263	4.281e-281	892.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HFD2_k127_7679932_2	926566.Terro_2992	4.019e-71	262.0	COG0666@1|root,COG0666@2|Bacteria,3Y6MI@57723|Acidobacteria,2JNNT@204432|Acidobacteriia	204432|Acidobacteriia	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7679932_4	649747.HMPREF0083_01770	4.127e-05	47.0	COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,2729A@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HFD2_k127_7685869_1	1133850.SHJG_5829	1.051e-24	121.0	COG1807@1|root,COG1807@2|Bacteria,2IB2Q@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_7685869_0	1133850.SHJG_5829	1.085e-25	123.0	COG1807@1|root,COG1807@2|Bacteria,2IB2Q@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_7693825_0	1274374.CBLK010000051_gene2056	2.407e-109	361.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HB31@91061|Bacilli,26QK1@186822|Paenibacillaceae	91061|Bacilli	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HFD2_k127_7693825_1	240015.ACP_2879	7.564e-80	271.0	COG0512@1|root,COG0512@2|Bacteria,3Y36D@57723|Acidobacteria,2JHQS@204432|Acidobacteriia	204432|Acidobacteriia	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD2_k127_7693825_2	1123276.KB893250_gene349	2.467e-13	70.0	COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,47JSS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_769557_2	1340493.JNIF01000003_gene4222	6.863e-51	184.0	COG1015@1|root,COG1015@2|Bacteria	2|Bacteria	G	phosphopentomutase activity	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Metalloenzyme
HFD2_k127_769557_0	234267.Acid_1969	1.539e-119	397.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria	2|Bacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_769557_1	234267.Acid_6219	1.399e-90	309.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HFD2_k127_770543_2	76114.ebA4052	1.103e-47	173.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,2KWJC@206389|Rhodocyclales	206389|Rhodocyclales	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HFD2_k127_770543_0	1232410.KI421417_gene2753	1.12e-65	233.0	COG1877@1|root,COG1877@2|Bacteria,1PF7W@1224|Proteobacteria,42QT9@68525|delta/epsilon subdivisions,2WNR9@28221|Deltaproteobacteria,43UM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HFD2_k127_770543_1	247490.KSU1_C1305	4.431e-59	210.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HFD2_k127_7722060_0	1382359.JIAL01000001_gene443	3.4e-202	650.0	COG3525@1|root,COG3525@2|Bacteria,3Y2P0@57723|Acidobacteria,2JHP8@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, family 20, catalytic core	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
HFD2_k127_7722060_1	391038.Bphy_2377	7.087e-108	374.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2VHGG@28216|Betaproteobacteria,1K3H2@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cellulose synthase	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glycos_transf_2,PilZ
HFD2_k127_7722060_2	1003200.AXXA_16422	1.056e-07	63.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria,3T868@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD2_k127_7724109_1	96561.Dole_1367	7.352e-65	255.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
HFD2_k127_7724109_2	861299.J421_2843	4.24e-47	182.0	COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD2_k127_7724109_4	502025.Hoch_3346	1.029e-21	109.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HFD2_k127_7724109_3	502025.Hoch_4617	7.883e-30	134.0	COG1716@1|root,COG1716@2|Bacteria,1Q2GC@1224|Proteobacteria,4382T@68525|delta/epsilon subdivisions,2X0C6@28221|Deltaproteobacteria,2YVG7@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HFD2_k127_7724109_0	234267.Acid_5820	1.754e-88	314.0	COG0312@1|root,COG0312@2|Bacteria,3Y686@57723|Acidobacteria	57723|Acidobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_7728752_0	1121920.AUAU01000006_gene306	1.341e-223	704.0	COG1506@1|root,COG1506@2|Bacteria,3Y2HK@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD2_k127_774212_0	234267.Acid_6378	2.809e-107	351.0	COG0556@1|root,COG0556@2|Bacteria,3Y31K@57723|Acidobacteria	57723|Acidobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD2_k127_7754009_0	886293.Sinac_7544	4.248e-191	621.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
HFD2_k127_7754009_7	1117319.PSPO_04087	8.822e-20	94.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2Q1AE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	rpfG	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HFD2_k127_7754009_8	1443111.JASG01000004_gene3062	4.976e-15	85.0	COG0745@1|root,COG0745@2|Bacteria,1R3XP@1224|Proteobacteria,2U3PX@28211|Alphaproteobacteria,3ZVGJ@60136|Sulfitobacter	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_7754009_3	1382359.JIAL01000001_gene1200	2.029e-73	252.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria,2JIEA@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD2_k127_7754009_2	204669.Acid345_3224	3.158e-98	336.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria,2JI54@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD2_k127_7754009_6	926550.CLDAP_24030	4.997e-22	100.0	COG4113@1|root,COG4113@2|Bacteria,2G8UN@200795|Chloroflexi	200795|Chloroflexi	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7754009_4	234267.Acid_3868	7.273e-65	229.0	COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria	57723|Acidobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HFD2_k127_7754009_5	156889.Mmc1_2003	9.705e-51	196.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HFD2_k127_7754009_1	234267.Acid_5693	2.795e-100	335.0	COG1234@1|root,COG1234@2|Bacteria,3Y7KR@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_7761763_2	1267535.KB906767_gene3785	4.979e-67	230.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HFD2_k127_7761763_4	596151.DesfrDRAFT_2713	1.799e-41	161.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2M9N8@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_7761763_1	204669.Acid345_3011	1.785e-135	443.0	COG0150@1|root,COG0150@2|Bacteria,3Y2GN@57723|Acidobacteria,2JITJ@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_7761763_5	221288.JH992901_gene3297	4.481e-41	156.0	COG0614@1|root,COG0614@2|Bacteria,1G7SF@1117|Cyanobacteria,1JITM@1189|Stigonemataceae	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD2_k127_7761763_0	1120970.AUBZ01000021_gene3218	3.958e-155	501.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria,469AW@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
HFD2_k127_7761763_6	1121445.ATUZ01000014_gene1484	2.956e-24	106.0	2B2V5@1|root,31VFQ@2|Bacteria,1QCMA@1224|Proteobacteria,436BA@68525|delta/epsilon subdivisions,2X0WD@28221|Deltaproteobacteria,2MDKE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Pathogenicity locus	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
HFD2_k127_7761763_3	204669.Acid345_3012	2.904e-61	215.0	COG0299@1|root,COG0299@2|Bacteria,3Y49G@57723|Acidobacteria,2JJ2U@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HFD2_k127_7781475_4	234267.Acid_0135	1.106e-20	95.0	COG0457@1|root,COG0457@2|Bacteria,3Y99M@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7781475_2	1267533.KB906733_gene3306	5.704e-39	153.0	COG2802@1|root,COG2802@2|Bacteria,3Y7JR@57723|Acidobacteria,2JMUX@204432|Acidobacteriia	204432|Acidobacteriia	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HFD2_k127_7781475_0	204669.Acid345_3256	1.104e-197	629.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
HFD2_k127_7781475_1	204669.Acid345_3257	7.78e-183	581.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
HFD2_k127_7781475_3	697329.Rumal_1458	3.524e-37	147.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,3WGIN@541000|Ruminococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HFD2_k127_7792201_0	1267535.KB906767_gene605	1.808e-157	504.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD2_k127_7794167_0	416348.Hlac_1335	3.437e-122	406.0	COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria	183963|Halobacteria	C	Nitrate reductase alpha subunit	narG	-	-	ko:K17050	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Molybdopterin,Molydop_binding
HFD2_k127_7794167_1	1125863.JAFN01000001_gene2793	7.838e-82	293.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_7794167_2	1125863.JAFN01000001_gene2794	3.514e-15	76.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_7843986_1	1244531.CIG1485E_0060	3.009e-95	328.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD2_k127_7843986_0	448385.sce7321	3.785e-102	346.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,42NYR@68525|delta/epsilon subdivisions,2WJB1@28221|Deltaproteobacteria,2Z0SK@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_7864982_8	1246474.ANBE01000003_gene2290	2.144e-06	56.0	COG0842@1|root,COG0842@2|Bacteria,2I1AX@201174|Actinobacteria,4EMPP@85012|Streptosporangiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC2_membrane_3
HFD2_k127_7864982_4	1340493.JNIF01000003_gene1412	5.496e-97	326.0	COG1131@1|root,COG1131@2|Bacteria,3Y4CW@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7864982_7	582515.KR51_00017370	4.439e-17	86.0	COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria	1117|Cyanobacteria	L	Methylated dna-protein cysteine methyltransferase	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
HFD2_k127_7864982_2	204669.Acid345_0710	2.342e-145	471.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria,2JMAK@204432|Acidobacteriia	204432|Acidobacteriia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HFD2_k127_7864982_5	1267533.KB906735_gene5073	4.256e-72	261.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria,2JK7Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_7864982_0	234267.Acid_0481	7.006e-236	738.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD2_k127_7864982_1	1267533.KB906733_gene2851	3.477e-164	529.0	COG0403@1|root,COG0403@2|Bacteria,3Y2WZ@57723|Acidobacteria,2JIU3@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD2_k127_7864982_6	240015.ACP_2097	1.22e-46	171.0	COG0509@1|root,COG0509@2|Bacteria,3Y51Z@57723|Acidobacteria,2JJI2@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD2_k127_7864982_3	234267.Acid_0484	4.125e-116	381.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria	57723|Acidobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_7879195_1	1382315.JPOI01000001_gene186	2.472e-18	85.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1WFBZ@129337|Geobacillus	91061|Bacilli	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD2_k127_7879195_0	1382359.JIAL01000001_gene1453	1.003e-29	128.0	COG2165@1|root,COG2165@2|Bacteria,3Y9CD@57723|Acidobacteria,2JP0S@204432|Acidobacteriia	204432|Acidobacteriia	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7879195_2	1267534.KB906755_gene4778	1.246e-17	89.0	2C8FF@1|root,333TN@2|Bacteria,3Y5GA@57723|Acidobacteria,2JJYB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7879195_3	1198114.AciX9_0948	1.098e-11	72.0	2CEAG@1|root,31NYW@2|Bacteria,3Y52E@57723|Acidobacteria,2JJI1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HFD2_k127_7879195_4	1198114.AciX9_0947	3.206e-11	72.0	COG3166@1|root,COG3166@2|Bacteria,3Y4GJ@57723|Acidobacteria,2JJ3Y@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HFD2_k127_788014_0	234267.Acid_1455	1.193e-107	364.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
HFD2_k127_788014_1	204669.Acid345_2867	5.92e-45	177.0	COG5267@1|root,COG5267@2|Bacteria,3Y342@57723|Acidobacteria,2JICP@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_7895894_1	1487953.JMKF01000045_gene2778	3.116e-57	206.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,1G17W@1117|Cyanobacteria,1H8ZH@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
HFD2_k127_7895894_0	1242864.D187_007369	1.469e-86	301.0	COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,42R2C@68525|delta/epsilon subdivisions,2WMZ7@28221|Deltaproteobacteria,2YV1V@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_7906716_0	123899.JPQP01000004_gene326	5.489e-22	108.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2WEDP@28216|Betaproteobacteria,3T2BN@506|Alcaligenaceae	28216|Betaproteobacteria	M	Glycosyltransferase Family 4	rfaG	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_7911589_0	1121946.AUAX01000035_gene6178	5.349e-244	773.0	COG0330@1|root,COG0330@2|Bacteria,2I9AF@201174|Actinobacteria	201174|Actinobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_7911589_4	204669.Acid345_0330	2.433e-48	179.0	2DC00@1|root,2ZC4V@2|Bacteria,3Y8QE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7911589_1	1267533.KB906738_gene2031	5.18e-140	449.0	COG1398@1|root,COG1398@2|Bacteria,3Y3F9@57723|Acidobacteria,2JHWH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_7911589_2	457421.CBFG_05233	1.518e-97	324.0	COG2326@1|root,COG2326@2|Bacteria,1TQQR@1239|Firmicutes,249HE@186801|Clostridia,267YH@186813|unclassified Clostridiales	186801|Clostridia	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
HFD2_k127_7911589_3	1499967.BAYZ01000016_gene6550	3.736e-67	240.0	COG2326@1|root,COG2326@2|Bacteria	2|Bacteria	S	polyphosphate kinase activity	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
HFD2_k127_7911589_6	1121943.KB900000_gene1270	1.691e-08	68.0	COG3063@1|root,COG3063@2|Bacteria,1N1YA@1224|Proteobacteria,1SB9Y@1236|Gammaproteobacteria,1XKND@135619|Oceanospirillales	135619|Oceanospirillales	NU	COG3063 Tfp pilus assembly protein PilF	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_1,TPR_12,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_7911589_7	29581.BW37_04296	8.203e-06	51.0	COG0726@1|root,COG4249@1|root,COG0726@2|Bacteria,COG4249@2|Bacteria,1PJQG@1224|Proteobacteria,2VIG8@28216|Betaproteobacteria,4757C@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Polysaccharide deacetylase	nodB	-	3.5.1.104,3.5.1.41	ko:K01452,ko:K14659,ko:K22278	ko00520,ko01100,map00520,map01100	M00664	R02333	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_C14,Polysacc_deac_1,TPR_16,TPR_8
HFD2_k127_7914103_0	204669.Acid345_2952	1.509e-177	566.0	COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria,2JIAC@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD2_k127_7914103_2	671143.DAMO_0479	1.635e-104	349.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HFD2_k127_7914103_1	706587.Desti_5093	1.069e-119	404.0	COG2202@1|root,COG3290@1|root,COG3829@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CQ0@68525|delta/epsilon subdivisions,2X7X9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HFD2_k127_7922692_0	234267.Acid_2445	1.926e-122	401.0	COG2234@1|root,COG2234@2|Bacteria,3Y3KE@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD2_k127_7922692_1	1382359.JIAL01000001_gene2768	4.519e-120	402.0	COG1022@1|root,COG1022@2|Bacteria,3Y2KU@57723|Acidobacteria,2JHTA@204432|Acidobacteriia	204432|Acidobacteriia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD2_k127_7936803_0	204669.Acid345_4393	1.34e-98	327.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_8
HFD2_k127_7936803_1	1379270.AUXF01000007_gene972	4.754e-09	62.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_7936803_2	1125971.ASJB01000083_gene2243	0.0001734	48.0	COG1225@1|root,COG1225@2|Bacteria,2H4Y3@201174|Actinobacteria,4E5X8@85010|Pseudonocardiales	201174|Actinobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_7950581_0	204669.Acid345_2030	2.052e-225	713.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria,2JIC5@204432|Acidobacteriia	204432|Acidobacteriia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD2_k127_7957563_0	401053.AciPR4_0237	8.831e-121	399.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HFD2_k127_7957563_2	1267535.KB906767_gene2451	4.323e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,3Y82D@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7957563_1	519989.ECTPHS_05861	1.015e-49	185.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales	135613|Chromatiales	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HFD2_k127_7957563_3	278963.ATWD01000001_gene3971	2.334e-30	126.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3Y2WU@57723|Acidobacteria,2JHYV@204432|Acidobacteriia	204432|Acidobacteriia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD2_k127_7960792_3	1267535.KB906767_gene2705	2.247e-51	183.0	COG0051@1|root,COG0051@2|Bacteria,3Y4V5@57723|Acidobacteria,2JJAS@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HFD2_k127_7960792_0	1267535.KB906767_gene2704	2.912e-76	261.0	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria,2JI91@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HFD2_k127_7960792_2	1267535.KB906767_gene2703	1.305e-65	232.0	COG0088@1|root,COG0088@2|Bacteria,3Y2PM@57723|Acidobacteria,2JIZE@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD2_k127_7960792_4	204669.Acid345_1228	2.004e-35	136.0	COG0089@1|root,COG0089@2|Bacteria,3Y58W@57723|Acidobacteria,2JJR2@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD2_k127_7960792_1	1121428.DESHY_150045___1	1.049e-73	252.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,260NI@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD2_k127_7983496_0	1454004.AW11_02136	2.246e-294	940.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2VK83@28216|Betaproteobacteria,1KQXK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 21	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_7985295_4	204669.Acid345_0767	3.341e-78	269.0	COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria	57723|Acidobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
HFD2_k127_7985295_3	234267.Acid_4204	2.579e-102	338.0	COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD2_k127_7985295_2	204669.Acid345_2602	1.593e-160	514.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD2_k127_7985295_0	204669.Acid345_2603	1.285e-192	618.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_7985295_1	234267.Acid_4207	9.33e-182	585.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_7985295_6	204669.Acid345_2605	2.412e-52	195.0	COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HFD2_k127_7985295_5	1121405.dsmv_3000	3.66e-77	273.0	COG0674@1|root,COG0674@2|Bacteria,1R4K0@1224|Proteobacteria,42NQJ@68525|delta/epsilon subdivisions,2WJ0K@28221|Deltaproteobacteria,2MIND@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HFD2_k127_7985295_7	326298.Suden_1054	2.002e-12	70.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2YMMW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Oxidoreductase	oorB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_7985721_1	234267.Acid_1455	1.567e-51	188.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
HFD2_k127_7985721_0	1128421.JAGA01000003_gene2936	4.018e-76	266.0	COG0506@1|root,COG0506@2|Bacteria,2NPED@2323|unclassified Bacteria	2|Bacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HFD2_k127_7985721_3	690850.Desaf_1137	1.666e-14	78.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,42VYW@68525|delta/epsilon subdivisions,2WR91@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7985721_2	1340493.JNIF01000003_gene2778	9.884e-21	100.0	COG1295@1|root,COG1295@2|Bacteria,3Y4P8@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ribonuclease	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD2_k127_7985972_2	926566.Terro_1489	4.639e-73	256.0	COG1136@1|root,COG1136@2|Bacteria,3Y412@57723|Acidobacteria,2JIJG@204432|Acidobacteriia	204432|Acidobacteriia	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HFD2_k127_7985972_0	1340493.JNIF01000003_gene1805	0.0	1271.0	COG0542@1|root,COG0542@2|Bacteria,3Y35D@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_7985972_1	234267.Acid_6470	1.461e-236	768.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria	57723|Acidobacteria	M	Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD2_k127_7985972_3	1198114.AciX9_1643	1.685e-05	58.0	COG5267@1|root,COG5267@2|Bacteria,3Y6EE@57723|Acidobacteria,2JMGR@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_7987084_2	1454007.JAUG01000037_gene4329	8.991e-111	365.0	COG0031@1|root,COG0031@2|Bacteria,4NF7E@976|Bacteroidetes,1IPYB@117747|Sphingobacteriia	976|Bacteroidetes	E	Cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_7987084_1	1379698.RBG1_1C00001G0607	1.045e-138	472.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HFD2_k127_7987084_0	32057.KB217478_gene7447	4.958e-154	494.0	COG0667@1|root,COG0667@2|Bacteria,1G2QT@1117|Cyanobacteria,1HRA6@1161|Nostocales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_7987084_3	1047013.AQSP01000019_gene976	6.831e-108	370.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD2_k127_798877_3	204669.Acid345_3771	3.996e-53	194.0	COG3034@1|root,COG3034@2|Bacteria,3Y5ET@57723|Acidobacteria	57723|Acidobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD2_k127_798877_2	1894.JOER01000058_gene3221	1.565e-69	248.0	COG0265@1|root,COG2319@1|root,COG0265@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,WD40
HFD2_k127_798877_0	204669.Acid345_2474	4.65e-170	582.0	COG2911@1|root,COG2911@2|Bacteria,3Y3A6@57723|Acidobacteria,2JHS8@204432|Acidobacteriia	204432|Acidobacteriia	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD2_k127_798877_4	215803.DB30_1415	1.637e-05	55.0	2AJ25@1|root,319KF@2|Bacteria,1Q32B@1224|Proteobacteria,438SQ@68525|delta/epsilon subdivisions,2X9CK@28221|Deltaproteobacteria,2YXP8@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_798877_1	204669.Acid345_2476	1.683e-141	471.0	COG0729@1|root,COG4775@1|root,COG0729@2|Bacteria,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	204432|Acidobacteriia	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HFD2_k127_7989257_2	278963.ATWD01000001_gene4283	1.279e-32	132.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HFD2_k127_7989257_6	314254.OA2633_12345	1.794e-07	61.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_7989257_5	1515746.HR45_11395	9.854e-23	114.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,2Q902@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM AsmA family protein	asmA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HFD2_k127_7989257_3	204669.Acid345_0810	4.845e-27	128.0	COG0810@1|root,COG0810@2|Bacteria,3Y8PD@57723|Acidobacteria	57723|Acidobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_7989257_0	76114.ebA232	1.477e-83	287.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,2KWGC@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD2_k127_7989257_1	290397.Adeh_4343	1.258e-64	237.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,42YS3@68525|delta/epsilon subdivisions,2WU59@28221|Deltaproteobacteria,2YTT1@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_7989257_4	1502724.FF80_02369	7.01e-25	109.0	COG1011@1|root,COG1011@2|Bacteria,1MX48@1224|Proteobacteria,2TUWQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD2_k127_8028108_1	1296416.JACB01000036_gene2829	6.545e-13	75.0	COG2303@1|root,COG2303@2|Bacteria,4PH1X@976|Bacteroidetes,1IMAH@117743|Flavobacteriia,2YJ6R@290174|Aquimarina	976|Bacteroidetes	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8028108_0	1356854.N007_08425	2.499e-25	113.0	COG0702@1|root,COG0702@2|Bacteria,1VEC8@1239|Firmicutes	1239|Firmicutes	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
HFD2_k127_804185_2	204669.Acid345_1314	1.099e-40	153.0	COG0852@1|root,COG0852@2|Bacteria,3Y4IQ@57723|Acidobacteria,2JJCT@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_804185_0	204669.Acid345_1313	5.642e-173	550.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria,2JIDU@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
HFD2_k127_804185_1	240015.ACP_0292	1.188e-60	218.0	COG1905@1|root,COG1905@2|Bacteria,3Y4SI@57723|Acidobacteria,2JJDP@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD2_k127_8056458_4	278963.ATWD01000002_gene534	0.0003345	45.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HFD2_k127_8056458_2	204669.Acid345_3321	9.02e-69	255.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria,2JIGS@204432|Acidobacteriia	204432|Acidobacteriia	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_8056458_0	1340493.JNIF01000003_gene4121	8.195e-176	569.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8056458_1	204669.Acid345_3552	1.281e-110	375.0	COG1352@1|root,COG1352@2|Bacteria	2|Bacteria	NT	protein-glutamate O-methyltransferase activity	cheR	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K03408,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,CheW,HATPase_c,HisKA,Methyltransf_11,Methyltransf_25,PAS_10,Response_reg
HFD2_k127_8056458_3	272134.KB731324_gene2861	1.913e-05	54.0	COG0457@1|root,COG0457@2|Bacteria,1G0BJ@1117|Cyanobacteria,1H956@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_8086439_0	1242864.D187_007523	3.209e-103	342.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,4345U@68525|delta/epsilon subdivisions,2X20T@28221|Deltaproteobacteria,2YVEZ@29|Myxococcales	28221|Deltaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS
HFD2_k127_8086439_1	1267535.KB906767_gene630	3.861e-101	334.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria,2JHYU@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_8086439_2	861299.J421_6141	1.214e-47	179.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6141|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8091826_4	234267.Acid_3593	1.256e-17	97.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_8091826_3	1267533.KB906733_gene3362	1.759e-106	368.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_8091826_1	1205680.CAKO01000035_gene212	2.3e-139	461.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,2JVYF@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8091826_2	1379270.AUXF01000001_gene2153	1.38e-124	413.0	2BS4J@1|root,32M5G@2|Bacteria,1ZUJX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8091826_0	1242864.D187_008994	0.0	1166.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD2_k127_8100930_0	1382359.JIAL01000001_gene12	8.379e-226	713.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HFD2_k127_8100930_2	234267.Acid_1028	9.727e-07	54.0	COG2331@1|root,COG2331@2|Bacteria,3Y92S@57723|Acidobacteria	57723|Acidobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD2_k127_8100930_1	234267.Acid_3593	4.913e-73	259.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_8119054_0	234267.Acid_0069	2.884e-73	271.0	COG1391@1|root,COG1391@2|Bacteria,3Y72J@57723|Acidobacteria	57723|Acidobacteria	H	Glutamate-ammonia ligase adenylyltransferase	-	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HFD2_k127_8119054_1	258594.RPA2813	2.589e-28	117.0	2AFVV@1|root,315YK@2|Bacteria,1NQAN@1224|Proteobacteria,2UNGW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8152487_4	378806.STAUR_1259	2.406e-45	179.0	COG0644@1|root,COG0644@2|Bacteria,1N3JT@1224|Proteobacteria,42S0W@68525|delta/epsilon subdivisions,2WVDD@28221|Deltaproteobacteria,2YU0R@29|Myxococcales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_8152487_1	765910.MARPU_05370	2.348e-74	259.0	298PG@1|root,2ZVTY@2|Bacteria,1RIKV@1224|Proteobacteria,1SQW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8152487_0	269799.Gmet_3488	3.918e-132	431.0	2DBVK@1|root,2ZBBH@2|Bacteria,1PWZS@1224|Proteobacteria,432W2@68525|delta/epsilon subdivisions,2WXWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HFD2_k127_8152487_3	1444711.CCJF01000005_gene431	1.602e-59	209.0	COG1764@1|root,COG1764@2|Bacteria,2JH2K@204428|Chlamydiae	204428|Chlamydiae	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HFD2_k127_8152487_2	886293.Sinac_6019	7.091e-69	238.0	29NNR@1|root,309KP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8167707_3	926566.Terro_1819	2.171e-35	141.0	COG0546@1|root,COG0546@2|Bacteria,3Y4RC@57723|Acidobacteria,2JMPI@204432|Acidobacteriia	204432|Acidobacteriia	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_8167707_0	204669.Acid345_0983	1.755e-144	493.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_8167707_4	1382359.JIAL01000001_gene1942	1.857e-18	86.0	COG0451@1|root,COG0451@2|Bacteria,3Y3ZG@57723|Acidobacteria,2JHT7@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_8167707_1	880073.Calab_2000	2.203e-87	301.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_8167707_5	929556.Solca_4298	2.727e-09	68.0	2DBU8@1|root,2ZB4S@2|Bacteria,4PKQU@976|Bacteroidetes,1J0IK@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HFD2_k127_8167707_2	591001.Acfer_1655	2.911e-48	179.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4H4BA@909932|Negativicutes	909932|Negativicutes	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD2_k127_8170838_10	1123053.AUDG01000002_gene2818	3.628e-14	81.0	2CD3D@1|root,32RWZ@2|Bacteria,1N61G@1224|Proteobacteria,1SB8Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_8170838_8	1173028.ANKO01000195_gene5941	2.684e-25	120.0	COG0775@1|root,COG0775@2|Bacteria,1GQP5@1117|Cyanobacteria,1HHYB@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1,SEFIR
HFD2_k127_8170838_9	998674.ATTE01000001_gene920	1.175e-24	119.0	COG0775@1|root,COG4783@1|root,COG0775@2|Bacteria,COG4783@2|Bacteria,1QXHY@1224|Proteobacteria	1224|Proteobacteria	F	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HFD2_k127_8170838_6	1121920.AUAU01000005_gene959	4.435e-53	199.0	2E0D8@1|root,32W02@2|Bacteria,3Y5V4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8170838_7	234267.Acid_6492	1.034e-51	186.0	COG1832@1|root,COG1832@2|Bacteria,3Y566@57723|Acidobacteria	57723|Acidobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD2_k127_8170838_2	671143.DAMO_1203	8.67e-102	345.0	COG0079@1|root,COG0079@2|Bacteria,2NNZK@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_8170838_4	234267.Acid_6491	7.909e-61	220.0	COG1187@1|root,COG1187@2|Bacteria,3Y3CQ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_8170838_1	204669.Acid345_2350	1.376e-116	383.0	COG0604@1|root,COG0604@2|Bacteria,3Y4BK@57723|Acidobacteria,2JJ1G@204432|Acidobacteriia	204432|Acidobacteriia	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_zinc_N
HFD2_k127_8170838_5	234267.Acid_6490	4.013e-59	214.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD2_k127_8170838_3	234267.Acid_6489	4.166e-70	246.0	COG1354@1|root,COG1354@2|Bacteria,3Y458@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD2_k127_8170838_0	204669.Acid345_3860	7.199e-133	434.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria,2JHXI@204432|Acidobacteriia	204432|Acidobacteriia	J	aminoacyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_8249466_1	671143.DAMO_2896	4.257e-58	216.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_8249466_0	1250232.JQNJ01000001_gene3316	3.708e-84	293.0	COG1409@1|root,COG1409@2|Bacteria,4NF9K@976|Bacteroidetes,1HY33@117743|Flavobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,MetallophosC,MetallophosN
HFD2_k127_8263216_2	204669.Acid345_2827	9.574e-35	134.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8263216_0	204669.Acid345_2826	9.458e-137	449.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
HFD2_k127_8263216_1	204669.Acid345_2825	4.041e-78	270.0	COG0627@1|root,COG0627@2|Bacteria,3Y8UN@57723|Acidobacteria	57723|Acidobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD2_k127_8263472_9	204669.Acid345_4225	1.018e-20	97.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria,2JICA@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HFD2_k127_8263472_0	278963.ATWD01000001_gene3003	1.28e-320	1020.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD2_k127_8263472_6	671143.DAMO_2535	5.928e-50	182.0	COG0615@1|root,COG0615@2|Bacteria,2NPMA@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	aut	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like
HFD2_k127_8263472_12	1122132.AQYH01000004_gene1564	2.588e-05	57.0	COG2267@1|root,COG2267@2|Bacteria,1QV4H@1224|Proteobacteria,2TWFN@28211|Alphaproteobacteria,4BNUC@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Thioesterase domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_8263472_7	1267533.KB906733_gene3419	8.751e-36	143.0	COG1396@1|root,COG1396@2|Bacteria,3Y52W@57723|Acidobacteria,2JJE1@204432|Acidobacteriia	204432|Acidobacteriia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD2_k127_8263472_5	234267.Acid_2701	2.128e-51	193.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_8263472_1	204669.Acid345_1531	6.874e-188	599.0	COG1012@1|root,COG1012@2|Bacteria,3Y3Z0@57723|Acidobacteria,2JI2S@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HFD2_k127_8263472_11	404589.Anae109_0307	9.622e-07	53.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HFD2_k127_8263472_13	1123261.AXDW01000022_gene195	0.0003616	53.0	COG5607@1|root,COG5607@2|Bacteria,1QD4H@1224|Proteobacteria,1T906@1236|Gammaproteobacteria,1XBH4@135614|Xanthomonadales	135614|Xanthomonadales	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HFD2_k127_8263472_10	411464.DESPIG_02815	1.724e-18	100.0	COG2206@1|root,COG2206@2|Bacteria,1NVPV@1224|Proteobacteria,42ZXR@68525|delta/epsilon subdivisions,2WVEU@28221|Deltaproteobacteria,2MBNH@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HFD2_k127_8263472_8	1303518.CCALI_01464	4.975e-23	105.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD2_k127_8263472_2	502025.Hoch_3517	2.419e-94	328.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,2YUZ0@29|Myxococcales	28221|Deltaproteobacteria	FP	Ppx/GppA phosphatase family	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HFD2_k127_8263472_4	1459636.NTE_00052	1.625e-57	212.0	COG0125@1|root,arCOG01891@2157|Archaea	1459636.NTE_00052|-	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD2_k127_8263472_3	696281.Desru_2898	2.236e-90	303.0	COG0125@1|root,COG0125@2|Bacteria,1V07S@1239|Firmicutes,24F7F@186801|Clostridia	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD2_k127_8277423_0	1267534.KB906755_gene4695	4.767e-190	615.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria,2JK9M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_8277423_2	234267.Acid_7893	2.393e-34	141.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K13292	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_8277423_1	234267.Acid_5311	2.681e-38	156.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8289525_3	1267533.KB906741_gene491	4.615e-07	59.0	COG2304@1|root,COG2304@2|Bacteria,3Y2QN@57723|Acidobacteria,2JI49@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8289525_4	1121918.ARWE01000001_gene3655	1.523e-05	56.0	COG0457@1|root,COG0457@2|Bacteria	1121918.ARWE01000001_gene3655|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8289525_2	146922.JOFU01000046_gene5651	9.697e-16	87.0	COG2197@1|root,COG2197@2|Bacteria,2IQMJ@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_8289525_1	1340493.JNIF01000003_gene4251	4.828e-25	119.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	FHA,VWA,VWA_2
HFD2_k127_8289525_0	204669.Acid345_0721	3.623e-103	346.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_8310290_4	204669.Acid345_2060	6.634e-56	203.0	COG0483@1|root,COG0483@2|Bacteria,3Y3GD@57723|Acidobacteria,2JHRB@204432|Acidobacteriia	204432|Acidobacteriia	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_8310290_3	204669.Acid345_2058	9.121e-59	215.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HFD2_k127_8310290_5	1267533.KB906737_gene1631	2.465e-45	170.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria,2JMGK@204432|Acidobacteriia	204432|Acidobacteriia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD2_k127_8310290_7	1340493.JNIF01000003_gene4083	4.402e-14	78.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,3Y519@57723|Acidobacteria	57723|Acidobacteria	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD2_k127_8310290_1	1242864.D187_010288	1.265e-89	304.0	COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
HFD2_k127_8310290_6	471223.GWCH70_0154	4.091e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1WETT@129337|Geobacillus	91061|Bacilli	K	binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription this protein is involved in detoxification and protection against antimicrobial	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_8310290_8	234267.Acid_6606	1.573e-11	72.0	2BXJ9@1|root,2ZNPM@2|Bacteria,3Y966@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8310290_11	483219.LILAB_00585	2.342e-09	71.0	COG3325@1|root,COG3534@1|root,COG3325@2|Bacteria,COG3534@2|Bacteria,1RDYE@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 18 family	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18
HFD2_k127_8310290_10	349521.HCH_05539	1.135e-09	67.0	29VB3@1|root,30GR8@2|Bacteria,1QTAF@1224|Proteobacteria,1SUK5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8310290_9	862908.BMS_0145	4.335e-11	75.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,DUF4953,DUF5117,DUF5118,MACPF,Peptidase_M10,Peptidase_M43
HFD2_k127_8310290_13	56780.SYN_01756	3.187e-08	66.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
HFD2_k127_8310290_14	1121374.KB891588_gene3320	6.231e-05	54.0	COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
HFD2_k127_8310290_12	1123228.AUIH01000009_gene1970	2.461e-08	63.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02457,ko:K02672,ko:K08084,ko:K08085	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GspH,N_methyl,PilS
HFD2_k127_8310290_0	1121377.KB906409_gene894	4.487e-91	314.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_8310290_2	118168.MC7420_1134	6.689e-69	239.0	COG0317@1|root,COG0317@2|Bacteria,1G0F8@1117|Cyanobacteria,1HA1X@1150|Oscillatoriales	1117|Cyanobacteria	KT	PFAM Metal-dependent phosphohydrolase, HD	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4
HFD2_k127_8320322_3	1313172.YM304_19070	1.306e-11	66.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4CN1D@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_8320322_2	406552.NJ7G_0658	2.183e-14	82.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,23TGQ@183963|Halobacteria	183963|Halobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_8320322_1	1379270.AUXF01000001_gene1884	6.517e-31	134.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HFD2_k127_8320322_0	693661.Arcve_1732	1.518e-53	200.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_8329386_2	401053.AciPR4_1104	6.766e-49	179.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria,2JHM9@204432|Acidobacteriia	204432|Acidobacteriia	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_8329386_1	1382359.JIAL01000001_gene2757	7.712e-55	198.0	COG0009@1|root,COG0009@2|Bacteria,3Y43Z@57723|Acidobacteria,2JI37@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
HFD2_k127_8329386_0	204669.Acid345_2613	1.618e-59	222.0	COG0566@1|root,COG0566@2|Bacteria,3Y4GM@57723|Acidobacteria,2JJ7T@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_8387813_0	316067.Geob_0948	8.57e-221	702.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HFD2_k127_8387813_1	313603.FB2170_15008	2.196e-12	67.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1HZ97@117743|Flavobacteriia,2PH89@252356|Maribacter	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
HFD2_k127_841731_0	330214.NIDE1131	1.384e-291	904.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HFD2_k127_841731_1	1487953.JMKF01000007_gene5886	1.899e-66	230.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1H7MX@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD2_k127_843665_3	76114.ebD88	3.188e-05	55.0	COG4968@1|root,COG4968@2|Bacteria,1MZZW@1224|Proteobacteria,2VU8H@28216|Betaproteobacteria,2KX3T@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type IV minor pilin ComP, DNA uptake sequence receptor	pilE	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
HFD2_k127_843665_2	1007103.AFHW01000025_gene361	4.143e-17	90.0	COG1555@1|root,COG1555@2|Bacteria,1VTMY@1239|Firmicutes	1239|Firmicutes	L	COG1555 DNA uptake protein and related DNA-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HFD2_k127_8467350_2	1267534.KB906755_gene4406	2.979e-46	171.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria,2JIBA@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD2_k127_8467350_0	1382359.JIAL01000001_gene2702	4.44e-131	433.0	COG1207@1|root,COG1207@2|Bacteria,3Y3SI@57723|Acidobacteria,2JIVK@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HFD2_k127_8467350_1	204669.Acid345_0085	5.843e-96	323.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria,2JI1R@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HFD2_k127_8467350_5	1120985.AUMI01000014_gene936	1.314e-06	60.0	COG0457@1|root,COG0457@2|Bacteria,1UKPT@1239|Firmicutes,4H6KP@909932|Negativicutes	909932|Negativicutes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_2,TPR_8
HFD2_k127_8467350_4	1382359.JIAL01000001_gene2778	8.193e-07	61.0	COG0457@1|root,COG0457@2|Bacteria,3Y3TS@57723|Acidobacteria,2JIJ1@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19
HFD2_k127_8467350_3	134676.ACPL_6788	4.75e-41	158.0	COG1305@1|root,COG1305@2|Bacteria,2IDNI@201174|Actinobacteria	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HFD2_k127_8503549_2	204669.Acid345_3344	2.642e-35	143.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HFD2_k127_8503549_0	234267.Acid_7265	1.48e-92	315.0	COG0564@1|root,COG0564@2|Bacteria,3Y3G8@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_8503549_1	204669.Acid345_2869	9.902e-67	239.0	COG0682@1|root,COG0682@2|Bacteria,3Y4HT@57723|Acidobacteria,2JJTI@204432|Acidobacteriia	204432|Acidobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HFD2_k127_8503549_3	550540.Fbal_0784	5.422e-31	132.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD2_k127_8503549_4	1232410.KI421420_gene3160	2.255e-17	84.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,43RZV@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	tRNA synthetases class I (K)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD2_k127_851904_2	682795.AciX8_2616	5.144e-34	131.0	COG0304@1|root,COG0304@2|Bacteria,3Y2NT@57723|Acidobacteria,2JMBR@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_851904_0	639030.JHVA01000001_gene1370	6.833e-77	277.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HH@57723|Acidobacteria,2JNZ8@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_851904_1	861299.J421_1516	3.217e-51	190.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	PGCP	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD2_k127_8519372_11	1129794.C427_0828	1.887e-08	58.0	COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,1RSR2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FH	uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HFD2_k127_8519372_10	234267.Acid_7658	1.449e-14	79.0	COG1953@1|root,COG1953@2|Bacteria,3Y2FU@57723|Acidobacteria	57723|Acidobacteria	FH	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HFD2_k127_8519372_3	1340493.JNIF01000003_gene2936	7.807e-150	489.0	COG1012@1|root,COG1012@2|Bacteria,3Y3V5@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141,ko:K22187	ko00040,ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00040,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667,R11768	RC00075,RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_8519372_2	234267.Acid_7662	5.789e-165	529.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.55	ko:K00823,ko:K15372	ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R01684	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_8519372_4	1396141.BATP01000059_gene2564	8.847e-139	446.0	COG0388@1|root,COG0388@2|Bacteria,46S7B@74201|Verrucomicrobia,2ITNA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_8519372_6	234267.Acid_5783	9.867e-97	338.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_8519372_1	204669.Acid345_0395	1.244e-188	637.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria,2JP02@204432|Acidobacteriia	204432|Acidobacteriia	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_8519372_8	1254432.SCE1572_26545	1.286e-68	248.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HFD2_k127_8519372_7	861299.J421_6109	8.46e-83	282.0	COG3279@1|root,COG3279@2|Bacteria,1ZUZN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD2_k127_8519372_5	926566.Terro_0969	1.325e-113	377.0	COG1858@1|root,COG1858@2|Bacteria,3Y46D@57723|Acidobacteria,2JJVZ@204432|Acidobacteriia	204432|Acidobacteriia	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD2_k127_8519372_0	886293.Sinac_2688	1.266e-230	721.0	COG3379@1|root,COG3379@2|Bacteria,2IYF3@203682|Planctomycetes	2|Bacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_8541112_2	204669.Acid345_2260	8.535e-13	73.0	COG2204@1|root,COG2204@2|Bacteria,3Y98S@57723|Acidobacteria,2JP05@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8
HFD2_k127_8541112_0	1267535.KB906767_gene4888	3.801e-118	387.0	COG0152@1|root,COG0152@2|Bacteria,3Y2KX@57723|Acidobacteria,2JIG6@204432|Acidobacteriia	204432|Acidobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6,6.3.4.13	ko:K01923,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD2_k127_8541112_1	1184267.A11Q_1706	6.173e-113	408.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2MSR8@213481|Bdellovibrionales,2WJZF@28221|Deltaproteobacteria	213481|Bdellovibrionales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD2_k127_8548624_5	330214.NIDE2553	3.63e-54	203.0	COG2870@1|root,COG2870@2|Bacteria,3J0GT@40117|Nitrospirae	40117|Nitrospirae	M	Phosphomethylpyrimidine kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
HFD2_k127_8548624_7	1340493.JNIF01000003_gene2818	1.358e-44	176.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_8548624_13	234267.Acid_2357	1.827e-21	96.0	COG2835@1|root,COG2835@2|Bacteria,3Y8VE@57723|Acidobacteria	57723|Acidobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HFD2_k127_8548624_0	1150474.JQJI01000024_gene1593	1.13e-153	510.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
HFD2_k127_8548624_10	880073.Calab_1964	1.806e-37	150.0	COG3382@1|root,COG3382@2|Bacteria,2NPUN@2323|unclassified Bacteria	2|Bacteria	S	B3/4 domain	XK27_07210	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4
HFD2_k127_8548624_12	221288.JH992901_gene1695	1.728e-22	102.0	COG1547@1|root,COG1547@2|Bacteria,1G7QG@1117|Cyanobacteria,1JIP0@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HFD2_k127_8548624_9	234267.Acid_1042	6.253e-41	152.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
HFD2_k127_8548624_8	1191523.MROS_1419	2.961e-44	177.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_8548624_11	1340493.JNIF01000003_gene4327	4.737e-26	116.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_8
HFD2_k127_8548624_3	525904.Tter_0760	2.762e-87	294.0	COG2220@1|root,COG2220@2|Bacteria,2NPQC@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Lactamase_B_2,Lactamase_B_3
HFD2_k127_8548624_4	204669.Acid345_3436	7.509e-56	203.0	COG4122@1|root,COG4122@2|Bacteria,3Y4X9@57723|Acidobacteria,2JMCH@204432|Acidobacteriia	204432|Acidobacteriia	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HFD2_k127_8548624_2	234267.Acid_2007	1.182e-99	339.0	COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HFD2_k127_8548624_1	1267533.KB906735_gene5080	1.028e-125	409.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria,2JIIK@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_8548624_6	671143.DAMO_2761	2.386e-47	172.0	COG0652@1|root,COG0652@2|Bacteria,2NPSW@2323|unclassified Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_8571859_0	234267.Acid_1755	4.315e-68	242.0	COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria	57723|Acidobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_8571859_1	204669.Acid345_0973	1.881e-56	218.0	COG4585@1|root,COG4585@2|Bacteria,3Y8CF@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_8571859_2	1123290.AUDQ01000014_gene1092	6.771e-05	53.0	COG0457@1|root,COG0457@2|Bacteria,1V1HX@1239|Firmicutes,4HG5V@91061|Bacilli,26DTC@186818|Planococcaceae	91061|Bacilli	S	Tetratricopeptide repeat	yrrB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
HFD2_k127_862640_0	1198114.AciX9_2790	1.483e-129	427.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia	204432|Acidobacteriia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD2_k127_862640_1	234267.Acid_1538	1.892e-67	234.0	COG0173@1|root,COG0173@2|Bacteria,3Y3SP@57723|Acidobacteria	57723|Acidobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD2_k127_8633712_2	861299.J421_1398	2.07e-54	196.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH
HFD2_k127_8633712_0	1122222.AXWR01000004_gene1702	6.993e-72	248.0	COG2080@1|root,COG2080@2|Bacteria,1WK3N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_8633712_1	234267.Acid_2226	7.174e-68	238.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_8639555_1	204669.Acid345_3885	4.683e-97	324.0	COG0547@1|root,COG0547@2|Bacteria,3Y3YF@57723|Acidobacteria,2JIGH@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_8639555_0	1267535.KB906767_gene3553	3.865e-165	528.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria,2JHR1@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HFD2_k127_8639555_2	1267535.KB906767_gene3554	2.527e-50	189.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria,2JHSN@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HFD2_k127_8652757_1	1121468.AUBR01000005_gene101	7.627e-91	304.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,42EQ1@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_8652757_3	1267535.KB906767_gene4180	6.91e-26	112.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_8652757_4	1267535.KB906767_gene680	1.601e-14	78.0	COG1983@1|root,COG1983@2|Bacteria,3Y5HA@57723|Acidobacteria	57723|Acidobacteria	KT	Phage shock protein C, PspC	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC,zinc_ribbon_2
HFD2_k127_8652757_2	396588.Tgr7_1788	1.118e-31	133.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HFD2_k127_8652757_0	204669.Acid345_1786	2.941e-229	720.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	204432|Acidobacteriia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD2_k127_8653350_2	404589.Anae109_1476	1.879e-26	113.0	COG0784@1|root,COG0784@2|Bacteria,1QYG7@1224|Proteobacteria,43E8C@68525|delta/epsilon subdivisions,2X7NA@28221|Deltaproteobacteria,2Z11B@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_8653350_1	1340493.JNIF01000003_gene1323	9.991e-65	238.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_6,YfiO
HFD2_k127_8653350_0	234267.Acid_3191	1.765e-79	272.0	COG0036@1|root,COG0036@2|Bacteria,3Y3YN@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD2_k127_8653350_3	204669.Acid345_4230	4.552e-11	66.0	COG2815@1|root,COG2815@2|Bacteria,3Y4UG@57723|Acidobacteria,2JJF0@204432|Acidobacteriia	204432|Acidobacteriia	S	PASTA domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
HFD2_k127_8667181_4	1382359.JIAL01000001_gene118	3.154e-70	243.0	COG0084@1|root,COG0084@2|Bacteria,3Y4DK@57723|Acidobacteria,2JJ1I@204432|Acidobacteriia	204432|Acidobacteriia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD2_k127_8667181_1	234267.Acid_3351	1.781e-108	361.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_8667181_0	234267.Acid_1085	7.097e-116	380.0	COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria	57723|Acidobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_8667181_2	388413.ALPR1_16294	2.763e-99	334.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HFD2_k127_8667181_3	234267.Acid_3974	1.666e-82	284.0	COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria	57723|Acidobacteria	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase
HFD2_k127_8695417_1	1267535.KB906767_gene1984	9.704e-105	343.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HFD2_k127_8695417_0	1267535.KB906767_gene5006	3.236e-164	525.0	COG0798@1|root,COG0798@2|Bacteria,3Y69M@57723|Acidobacteria,2JP2H@204432|Acidobacteriia	204432|Acidobacteriia	P	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
HFD2_k127_8695417_2	1267534.KB906759_gene1870	1.319e-37	153.0	COG0526@1|root,COG0526@2|Bacteria,3Y5MI@57723|Acidobacteria,2JK2H@204432|Acidobacteriia	204432|Acidobacteriia	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HFD2_k127_8702186_1	234267.Acid_1376	1.956e-127	424.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_8702186_0	234267.Acid_7759	5.776e-269	847.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria	57723|Acidobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HFD2_k127_8702186_2	1009370.ALO_14357	9.522e-28	114.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,4H55W@909932|Negativicutes	909932|Negativicutes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD2_k127_8714002_3	234267.Acid_5254	1.709e-33	133.0	COG3608@1|root,COG3608@2|Bacteria,3Y8T6@57723|Acidobacteria	2|Bacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HFD2_k127_8714002_2	1267535.KB906767_gene3259	3.235e-39	150.0	COG0838@1|root,COG0838@2|Bacteria,3Y59B@57723|Acidobacteria,2JNDX@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD2_k127_8714002_1	204669.Acid345_1288	1.077e-58	212.0	COG0852@1|root,COG0852@2|Bacteria,3Y5E8@57723|Acidobacteria,2JNBQ@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_8714002_0	234267.Acid_5684	6.731e-71	242.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HFD2_k127_8744863_1	1382306.JNIM01000001_gene1806	3.082e-16	83.0	COG1371@1|root,COG1371@2|Bacteria,2G7BQ@200795|Chloroflexi	200795|Chloroflexi	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HFD2_k127_8744863_0	1278073.MYSTI_02808	2.137e-125	410.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria	1224|Proteobacteria	S	major pilin protein fima	MA20_16755	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HFD2_k127_8748009_1	1382359.JIAL01000001_gene2021	2.16e-80	282.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria,2JIAG@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HFD2_k127_8748009_0	1267535.KB906767_gene4285	9.062e-118	393.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD2_k127_8758558_1	926566.Terro_0138	5.616e-59	209.0	28JSD@1|root,2Z9HW@2|Bacteria,3Y3I3@57723|Acidobacteria,2JIM7@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8758558_2	1267533.KB906740_gene340	4.075e-44	168.0	2BBKR@1|root,3254K@2|Bacteria,3Y4Z0@57723|Acidobacteria,2JJH7@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8758558_4	1173026.Glo7428_0024	3.081e-06	56.0	COG1357@1|root,COG1357@2|Bacteria,1G664@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HFD2_k127_8758558_3	1382359.JIAL01000001_gene1178	1.145e-19	96.0	2F9D6@1|root,341Q1@2|Bacteria,3Y5CS@57723|Acidobacteria,2JNBU@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8758558_0	204669.Acid345_4357	8.249e-71	251.0	28Q2X@1|root,2ZCKQ@2|Bacteria,3Y4C5@57723|Acidobacteria,2JJ6W@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_879197_6	243231.GSU3318	3.256e-106	359.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
HFD2_k127_879197_14	43989.cce_4430	2.691e-08	66.0	COG4447@1|root,COG4447@2|Bacteria,1G2KP@1117|Cyanobacteria,3KIGV@43988|Cyanothece	1117|Cyanobacteria	S	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HFD2_k127_879197_13	204669.Acid345_4448	2.59e-28	127.0	COG1595@1|root,COG1595@2|Bacteria,3Y7TB@57723|Acidobacteria,2JMZD@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
HFD2_k127_879197_8	1267535.KB906767_gene4795	1.093e-56	205.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria,2JJ2F@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
HFD2_k127_879197_1	204669.Acid345_0762	6.782e-261	822.0	COG1529@1|root,COG1529@2|Bacteria,3Y2ME@57723|Acidobacteria,2JIZI@204432|Acidobacteriia	204432|Acidobacteriia	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_879197_5	234267.Acid_2421	1.25e-107	358.0	COG1319@1|root,COG1319@2|Bacteria,3Y3NU@57723|Acidobacteria	57723|Acidobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_879197_9	204669.Acid345_0765	4.089e-54	198.0	COG5588@1|root,COG5588@2|Bacteria,3Y7RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HFD2_k127_879197_11	886293.Sinac_3193	2.678e-34	141.0	2E6AH@1|root,330YD@2|Bacteria,2J11U@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_879197_2	1227739.Hsw_3687	3.678e-204	663.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NF70@976|Bacteroidetes,47JEZ@768503|Cytophagia	976|Bacteroidetes	EU	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD2_k127_879197_16	204669.Acid345_3231	6.845e-05	52.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_879197_4	566466.NOR53_1474	1.363e-109	365.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1S00K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HFD2_k127_879197_7	335543.Sfum_2435	5.686e-77	274.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42Q6P@68525|delta/epsilon subdivisions,2X5QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_879197_3	335543.Sfum_2436	2.705e-129	428.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MRTA@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
HFD2_k127_879197_15	380749.HY04AAS1_0502	2.044e-06	59.0	COG1349@1|root,COG1349@2|Bacteria,2G501@200783|Aquificae	200783|Aquificae	K	Transcriptional regulator, DeoR family	-	-	-	ko:K21601	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,NosL
HFD2_k127_879197_0	335543.Sfum_2437	0.0	1651.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
HFD2_k127_879197_12	118005.AWNK01000014_gene882	1.528e-32	142.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
HFD2_k127_879197_10	404589.Anae109_3729	3.116e-47	190.0	COG3202@1|root,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	HEAT_2,TLC,cNMP_binding
HFD2_k127_88478_4	234267.Acid_4363	2.275e-110	367.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria	57723|Acidobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HFD2_k127_88478_13	204669.Acid345_2189	7.577e-32	134.0	COG0457@1|root,COG0457@2|Bacteria,3Y4XQ@57723|Acidobacteria,2JJFK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_88478_6	204669.Acid345_0708	1.533e-92	307.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
HFD2_k127_88478_17	1267535.KB906767_gene9	1.66e-10	71.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_88478_15	1297742.A176_00518	9.095e-21	97.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42WXG@68525|delta/epsilon subdivisions,2WT19@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HFD2_k127_88478_9	32049.SYNPCC7002_A1579	2.297e-58	214.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H2N8@1129|Synechococcus	1117|Cyanobacteria	L	Endonuclease V	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
HFD2_k127_88478_12	748658.KB907318_gene1058	3.368e-35	145.0	COG2199@1|root,COG3706@2|Bacteria,1MZQ8@1224|Proteobacteria,1RS4B@1236|Gammaproteobacteria,1WXHB@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_88478_0	357808.RoseRS_4018	7.021e-262	829.0	COG0243@1|root,COG0243@2|Bacteria,2G7V5@200795|Chloroflexi,375JH@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HFD2_k127_88478_16	1267533.KB906745_gene70	1.169e-12	78.0	COG3218@1|root,COG3218@2|Bacteria	2|Bacteria	Q	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HFD2_k127_88478_18	1218074.BAXZ01000002_gene423	1.169e-09	69.0	COG1463@1|root,COG1463@2|Bacteria,1RA0J@1224|Proteobacteria,2WEF6@28216|Betaproteobacteria,1KHR4@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD2_k127_88478_14	765420.OSCT_1184	3.834e-22	103.0	COG0745@1|root,COG0745@2|Bacteria	765420.OSCT_1184|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_88478_3	686340.Metal_3581	1.14e-117	410.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,1RX1M@1236|Gammaproteobacteria,1XG7H@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_88478_5	671143.DAMO_0479	6.921e-110	367.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HFD2_k127_88478_2	204669.Acid345_3014	5.114e-131	449.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_88478_10	1173026.Glo7428_2204	1.537e-51	189.0	COG0784@1|root,COG0784@2|Bacteria,1GQ4W@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM response regulator receiveR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_88478_1	386456.JQKN01000001_gene1802	2.758e-185	619.0	COG0642@1|root,COG3413@1|root,arCOG02348@1|root,arCOG02350@1|root,arCOG03567@1|root,arCOG06712@1|root,arCOG02278@2157|Archaea,arCOG02348@2157|Archaea,arCOG02350@2157|Archaea,arCOG02358@2157|Archaea,arCOG03567@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,HisKA_4TM,MEDS,PAS,PAS_3,PAS_4,PAS_9
HFD2_k127_88478_7	1499967.BAYZ01000135_gene85	1.733e-88	299.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_88478_19	1187851.A33M_4434	2.164e-07	56.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2UFXF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD2_k127_88478_8	350058.Mvan_5836	1.881e-65	241.0	COG3315@1|root,COG3315@2|Bacteria,2GNGD@201174|Actinobacteria,234ZU@1762|Mycobacteriaceae	201174|Actinobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HFD2_k127_88478_11	1041146.ATZB01000028_gene5730	9.018e-36	140.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_88478_20	207559.Dde_0023	0.0007844	42.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,43B0R@68525|delta/epsilon subdivisions,2X6ET@28221|Deltaproteobacteria,2M9J0@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_887339_5	204669.Acid345_4142	2.454e-89	308.0	COG1505@1|root,COG1505@2|Bacteria,3Y2UH@57723|Acidobacteria,2JI70@204432|Acidobacteriia	204432|Acidobacteriia	E	Prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_887339_0	635013.TherJR_2465	1.861e-190	612.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,260S4@186807|Peptococcaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_887339_6	234267.Acid_4252	5.008e-87	298.0	COG0613@1|root,COG0613@2|Bacteria,3Y2US@57723|Acidobacteria	57723|Acidobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_887339_3	204669.Acid345_3656	3.211e-147	477.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HFD2_k127_887339_4	204669.Acid345_4600	2.258e-145	477.0	COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria,2JJG2@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_887339_1	204669.Acid345_1269	3.311e-185	587.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_887339_2	204669.Acid345_1270	4.455e-166	529.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HFD2_k127_891036_2	234267.Acid_4387	5.562e-82	274.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_891036_1	234267.Acid_4386	1.508e-143	461.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
HFD2_k127_891036_0	234267.Acid_4385	0.0	1064.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
HFD2_k127_891036_4	234267.Acid_4384	9.365e-67	235.0	COG3794@1|root,COG3794@2|Bacteria,3Y4A0@57723|Acidobacteria	57723|Acidobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_891036_5	234267.Acid_4383	1.139e-51	195.0	COG1612@1|root,COG1612@2|Bacteria	2|Bacteria	O	heme a metabolic process	ctaA	-	-	ko:K02259,ko:K03110	ko00190,ko00860,ko01100,ko01110,ko02020,ko02024,ko03060,ko03070,ko04714,map00190,map00860,map01100,map01110,map02020,map02024,map03060,map03070,map04714	M00154,M00335	R07412	RC00769	ko00000,ko00001,ko00002,ko02044,ko03029	3.A.5.1,3.A.5.2,3.A.5.7,3.D.4.4	-	-	COX15-CtaA
HFD2_k127_891036_3	1267535.KB906767_gene1277	1.732e-74	260.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HFD2_k127_891036_6	478741.JAFS01000002_gene876	7.923e-06	49.0	COG2322@1|root,COG2322@2|Bacteria,46SZT@74201|Verrucomicrobia,37GQA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HFD2_k127_895243_5	580332.Slit_1031	9.269e-37	150.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2VMUD@28216|Betaproteobacteria,44VN0@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_895243_3	179408.Osc7112_0136	4.817e-68	240.0	COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,1H93G@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HFD2_k127_895243_0	525904.Tter_0039	1.397e-138	452.0	COG2046@1|root,COG2046@2|Bacteria,2NNS5@2323|unclassified Bacteria	2|Bacteria	P	PUA-like domain	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
HFD2_k127_895243_4	240015.ACP_1166	4.055e-40	153.0	COG0529@1|root,COG0647@1|root,COG0529@2|Bacteria,COG0647@2|Bacteria,3Y5BG@57723|Acidobacteria,2JJR9@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HFD2_k127_895243_1	886293.Sinac_2689	4.913e-82	298.0	COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
HFD2_k127_895243_2	886293.Sinac_3509	1.155e-69	258.0	COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
HFD2_k127_9112_0	278963.ATWD01000001_gene2396	0.0	1332.0	COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria,2JIHS@204432|Acidobacteriia	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	swrC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD2_k127_9112_5	278963.ATWD01000001_gene2397	1.811e-70	255.0	COG0845@1|root,COG0845@2|Bacteria,3Y3C9@57723|Acidobacteria,2JIN9@204432|Acidobacteriia	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_9112_4	278963.ATWD01000001_gene2398	9.607e-87	302.0	COG1538@1|root,COG1538@2|Bacteria,3Y3PX@57723|Acidobacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340,ko:K15725	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,1.B.17.2.2,2.A.6.2	-	-	OEP
HFD2_k127_9112_1	234267.Acid_3680	1.418e-248	795.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HFD2_k127_9112_7	1444309.JAQG01000095_gene401	2.581e-14	82.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_9112_6	1267534.KB906755_gene4690	7.022e-61	222.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315,ko:K16928	-	M00582	-	-	ko00000,ko00002,ko01000,ko02000,ko03021	3.A.1.33	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
HFD2_k127_9112_3	1267534.KB906755_gene4691	1.825e-110	361.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_9112_2	1267533.KB906733_gene2989	3.009e-178	575.0	COG0642@1|root,COG2205@2|Bacteria,3Y2M7@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_914349_10	1267535.KB906767_gene1582	4.641e-39	147.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD2_k127_914349_0	234267.Acid_0490	0.0	1156.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
HFD2_k127_914349_6	1128421.JAGA01000003_gene2872	1.739e-75	258.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD2_k127_914349_8	1340493.JNIF01000004_gene149	1.325e-60	217.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_914349_2	1128421.JAGA01000003_gene2874	1.022e-121	409.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_914349_12	234267.Acid_0495	1.931e-18	93.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_914349_5	234267.Acid_0496	3.038e-81	280.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD2_k127_914349_3	234267.Acid_0497	6.846e-112	374.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD2_k127_914349_1	234267.Acid_0498	2.789e-279	865.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_914349_7	204669.Acid345_2994	1.82e-75	259.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria,2JI50@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_914349_11	1382359.JIAL01000001_gene967	5.475e-20	92.0	2DR0H@1|root,339NS@2|Bacteria,3Y59F@57723|Acidobacteria,2JJP9@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD2_k127_914349_9	204669.Acid345_0534	3.996e-40	164.0	COG0738@1|root,COG0738@2|Bacteria,3Y57Y@57723|Acidobacteria,2JJQE@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_914349_4	240015.ACP_1387	5.383e-88	301.0	COG0493@1|root,COG0493@2|Bacteria,3Y3EA@57723|Acidobacteria,2JJCC@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1,1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R10159,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HFD2_k127_925786_0	357808.RoseRS_3113	9.893e-94	312.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi,375CE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_925786_2	1120951.AUBG01000016_gene3537	9.97e-38	147.0	COG0454@1|root,COG0456@2|Bacteria,4NQCD@976|Bacteroidetes,1I3A0@117743|Flavobacteriia	976|Bacteroidetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_925786_1	1210884.HG799472_gene14912	1.698e-50	183.0	COG0607@1|root,COG0607@2|Bacteria,2IZWR@203682|Planctomycetes	203682|Planctomycetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_925786_3	1267534.KB906756_gene335	2.876e-33	134.0	COG2010@1|root,COG2010@2|Bacteria,3Y8FR@57723|Acidobacteria,2JNE2@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_925786_4	1121422.AUMW01000030_gene59	2.322e-14	74.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,260JQ@186807|Peptococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD2_k127_930390_9	1235794.C811_00299	1.646e-29	121.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4CV1B@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD2_k127_930390_11	1267535.KB906767_gene3216	1.64e-23	107.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_930390_10	118161.KB235922_gene3320	9.24e-25	106.0	COG1225@1|root,COG1225@2|Bacteria,1G6AA@1117|Cyanobacteria,3VJWP@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM AhpC TSA family	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_930390_13	1298863.AUEP01000017_gene4132	1.828e-10	65.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4DQGR@85009|Propionibacteriales	201174|Actinobacteria	O	Redoxin	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_930390_12	926560.KE387023_gene2483	4.853e-12	74.0	293K9@1|root,2ZR28@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_930390_0	1267535.KB906767_gene3899	7.567e-192	612.0	COG0064@1|root,COG0064@2|Bacteria,3Y2TJ@57723|Acidobacteria,2JI20@204432|Acidobacteriia	204432|Acidobacteriia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD2_k127_930390_14	1110502.TMO_1857	0.0004857	43.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2JQH9@204441|Rhodospirillales	204441|Rhodospirillales	H	TonB-dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HFD2_k127_930390_3	204669.Acid345_4483	5.177e-83	303.0	COG4206@1|root,COG4206@2|Bacteria,3Y42S@57723|Acidobacteria,2JHUU@204432|Acidobacteriia	204432|Acidobacteriia	H	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_930390_7	335543.Sfum_2739	2.075e-50	197.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2MR4D@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_930390_5	926561.KB900617_gene1663	1.392e-71	254.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WAHZ@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HFD2_k127_930390_6	477974.Daud_1317	1.523e-55	207.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,261KK@186807|Peptococcaceae	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HFD2_k127_930390_4	204669.Acid345_1262	4.12e-77	266.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100,4.2.1.17	ko:K01715,ko:K07537	ko00362,ko00650,ko01100,ko01120,ko01200,ko01220,map00362,map00650,map01100,map01120,map01200,map01220	M00541	R03026,R05597	RC00831,RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_930390_1	1379698.RBG1_1C00001G0804	1.736e-121	402.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_930390_2	234267.Acid_0583	2.46e-86	302.0	COG3191@1|root,COG3191@2|Bacteria,3Y6EN@57723|Acidobacteria	57723|Acidobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HFD2_k127_930390_8	1340493.JNIF01000003_gene1514	2.67e-31	133.0	COG3485@1|root,COG3485@2|Bacteria,3Y9A8@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_934219_0	358681.BBR47_54980	1.84e-109	362.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26R8M@186822|Paenibacillaceae	91061|Bacilli	I	Dehydrogenase	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_934219_1	1265503.KB905164_gene2037	1.784e-23	117.0	COG1073@1|root,COG1073@2|Bacteria,1RBP3@1224|Proteobacteria,1S216@1236|Gammaproteobacteria,2Q5Y1@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_934219_2	1144275.COCOR_07897	6.533e-14	85.0	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,4396X@68525|delta/epsilon subdivisions,2X4DR@28221|Deltaproteobacteria,2YYTQ@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,TPR_2
HFD2_k127_934219_3	1463861.JNXE01000006_gene5649	2.702e-10	74.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
HFD2_k127_945742_0	1382359.JIAL01000001_gene3036	1.409e-112	369.0	COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria,2JK79@204432|Acidobacteriia	204432|Acidobacteriia	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
HFD2_k127_945742_1	204669.Acid345_2224	5.733e-68	243.0	COG0598@1|root,COG0598@2|Bacteria,3Y4BT@57723|Acidobacteria,2JJ37@204432|Acidobacteriia	204432|Acidobacteriia	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD2_k127_945742_2	756067.MicvaDRAFT_0207	8.698e-08	55.0	COG1324@1|root,COG1324@2|Bacteria,1G7PJ@1117|Cyanobacteria,1HCDQ@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD2_k127_950366_10	234267.Acid_0461	2.703e-13	78.0	COG0711@1|root,COG0711@2|Bacteria,3Y4UJ@57723|Acidobacteria	57723|Acidobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_950366_7	234267.Acid_0462	4.636e-34	138.0	COG0712@1|root,COG0712@2|Bacteria,3Y4Z4@57723|Acidobacteria	57723|Acidobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD2_k127_950366_1	1267535.KB906767_gene3120	2.427e-237	744.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria,2JIEV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD2_k127_950366_6	1340493.JNIF01000004_gene350	2.946e-86	293.0	COG0224@1|root,COG0224@2|Bacteria,3Y3MN@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HFD2_k127_950366_0	1382359.JIAL01000001_gene2069	7.68e-249	775.0	COG0055@1|root,COG0055@2|Bacteria,3Y2PU@57723|Acidobacteria,2JIDM@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD2_k127_950366_9	204669.Acid345_4331	1.203e-32	131.0	COG0355@1|root,COG0355@2|Bacteria,3Y515@57723|Acidobacteria,2JJJV@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HFD2_k127_950366_4	204669.Acid345_2780	1.495e-102	346.0	COG1820@1|root,COG1820@2|Bacteria,3Y3NQ@57723|Acidobacteria,2JIST@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_950366_11	204669.Acid345_1753	7.846e-09	63.0	2EQAC@1|root,33HWH@2|Bacteria,3Y5W6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_950366_8	1382359.JIAL01000001_gene141	1.177e-33	143.0	COG1322@1|root,COG1322@2|Bacteria,3Y3JC@57723|Acidobacteria,2JHYC@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_950366_5	1123269.NX02_19075	1.93e-95	329.0	COG0006@1|root,COG0006@2|Bacteria,1NR7D@1224|Proteobacteria,2UPAG@28211|Alphaproteobacteria,2K8WM@204457|Sphingomonadales	204457|Sphingomonadales	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_950366_3	1267533.KB906737_gene1578	4.62e-105	347.0	COG0501@1|root,COG0501@2|Bacteria,3Y3EZ@57723|Acidobacteria,2JIIZ@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD2_k127_950366_2	240015.ACP_2407	2.075e-194	617.0	COG0542@1|root,COG0542@2|Bacteria,3Y2X9@57723|Acidobacteria,2JIAE@204432|Acidobacteriia	204432|Acidobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_964346_1	1267535.KB906767_gene717	2.262e-143	459.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD2_k127_964346_0	204669.Acid345_2194	9.811e-152	489.0	COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria,2JIB8@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM Carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD2_k127_964346_3	204669.Acid345_2191	6.764e-62	223.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria,2JJ4I@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD2_k127_964346_2	1356852.N008_19465	1.753e-72	254.0	COG0463@1|root,COG0463@2|Bacteria,4PKIQ@976|Bacteroidetes,47YFC@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_964346_6	1125863.JAFN01000001_gene1668	1.576e-09	69.0	2ER9F@1|root,33IV2@2|Bacteria,1P4XJ@1224|Proteobacteria,433CC@68525|delta/epsilon subdivisions,2WXNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_964346_5	204669.Acid345_3241	4.955e-35	140.0	COG1385@1|root,COG1385@2|Bacteria,3Y3XJ@57723|Acidobacteria,2JI6A@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD2_k127_975403_5	196162.Noca_4181	1.386e-14	74.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria,4DPK0@85009|Propionibacteriales	201174|Actinobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_975403_0	760568.Desku_3528	2.387e-98	331.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,263QH@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_975403_4	1408164.MOLA814_00703	5.065e-42	162.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2WEA7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
HFD2_k127_975403_3	448385.sce3747	8.141e-49	184.0	COG0279@1|root,COG0279@2|Bacteria,1R8MP@1224|Proteobacteria,42TNC@68525|delta/epsilon subdivisions,2WR5G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD2_k127_975403_1	1047013.AQSP01000116_gene1113	5.642e-92	314.0	COG0673@1|root,COG0673@2|Bacteria,2NQ2X@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_975403_2	1210884.HG799467_gene13161	1.639e-68	244.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_984575_2	204669.Acid345_1764	7.019e-87	311.0	COG5373@1|root,COG5373@2|Bacteria,3Y2GV@57723|Acidobacteria,2JIMY@204432|Acidobacteriia	204432|Acidobacteriia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HFD2_k127_984575_5	204669.Acid345_1759	1.307e-17	97.0	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF3999,LptC,NLPC_P60,SH3_3
HFD2_k127_984575_1	63737.Npun_R0239	2.724e-118	389.0	COG2520@1|root,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD2_k127_984575_3	756272.Plabr_4030	3.681e-56	205.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_984575_6	1173023.KE650771_gene5245	3.094e-12	75.0	COG2931@1|root,COG2931@2|Bacteria,1G8MF@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_984575_0	525897.Dbac_1184	7.914e-202	640.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2MBD3@213115|Desulfovibrionales	28221|Deltaproteobacteria	CE	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HFD2_k127_984575_4	204669.Acid345_4392	1.093e-47	176.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HFD2_k127_987331_1	1442599.JAAN01000018_gene2871	6.593e-96	329.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RT11@1236|Gammaproteobacteria,1XCXH@135614|Xanthomonadales	135614|Xanthomonadales	EU	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_987331_0	1121428.DESHY_40191___1	1.937e-228	721.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,2601Q@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HFD2_k127_987331_2	1408254.T458_10145	2.302e-93	314.0	COG0477@1|root,COG2814@2|Bacteria,1TQM0@1239|Firmicutes,4HATA@91061|Bacilli,26R88@186822|Paenibacillaceae	91061|Bacilli	EGP	Major Facilitator	-	-	-	ko:K08196	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
## 2901 queries scanned
## Total time (seconds): 246.49770426750183
## Rate: 11.77 q/s