## Wed Nov 13 01:47:33 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD2_bin.67.fa -m mmseqs --itype genome -o HFD2_bin.67 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD2_bin.67 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD2_k127_1009990_6	1380393.JHVP01000002_gene1637	9.114e-08	62.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4EU6V@85013|Frankiales	201174|Actinobacteria	DT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
HFD2_k127_1009990_0	1313172.YM304_23260	5.031e-218	692.0	COG0465@1|root,COG0465@2|Bacteria,2I9X7@201174|Actinobacteria,4CNSR@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M41	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
HFD2_k127_1009990_5	1236902.ANAS01000018_gene3274	1.073e-11	78.0	COG1186@1|root,COG1186@2|Bacteria,2IFEJ@201174|Actinobacteria	201174|Actinobacteria	J	chain release factor	yaeJ	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HFD2_k127_1009990_2	324602.Caur_3552	1.788e-86	308.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
HFD2_k127_1009990_3	1869.MB27_38565	2.09e-60	213.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria,4DCRC@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD2_k127_1009990_1	1313172.YM304_38900	2.086e-100	336.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
HFD2_k127_1009990_7	1313172.YM304_38910	5.206e-06	49.0	2A58G@1|root,30TXM@2|Bacteria,2HG9Z@201174|Actinobacteria,4CN8R@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1101750_7	1313172.YM304_21920	7.344e-154	494.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4CNRU@84992|Acidimicrobiia	84992|Acidimicrobiia	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_1101750_30	1336208.JADY01000001_gene1058	1.692e-06	57.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,2U56J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD2_k127_1101750_25	710686.Mycsm_00690	2.188e-26	113.0	COG5483@1|root,COG5483@2|Bacteria,2IG6G@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488,HTH_31
HFD2_k127_1101750_15	1313172.YM304_15430	1.122e-99	335.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HFD2_k127_1101750_21	1313172.YM304_15390	6.094e-48	178.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria	201174|Actinobacteria	L	nuclease	-	-	3.1.31.1	ko:K01174,ko:K07038	-	-	-	-	ko00000,ko01000	-	-	-	SNase
HFD2_k127_1101750_10	1313172.YM304_15380	1.678e-128	415.0	COG3394@1|root,COG3394@2|Bacteria,2HG9M@201174|Actinobacteria,4CN7Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HFD2_k127_1101750_8	1313172.YM304_15360	4.061e-141	460.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4CN0C@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HFD2_k127_1101750_24	1313172.YM304_15350	1.332e-27	122.0	COG1881@1|root,COG1881@2|Bacteria	2|Bacteria	S	positive regulation of acetylcholine metabolic process	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD2_k127_1101750_1	1313172.YM304_02870	2.142e-235	743.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4CNFX@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1101750_27	1323361.JPOC01000008_gene3446	1.506e-19	102.0	2AQPD@1|root,31FWY@2|Bacteria,2HJK0@201174|Actinobacteria,4G6YZ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1101750_17	1313172.YM304_15320	1.487e-79	274.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
HFD2_k127_1101750_14	316274.Haur_3716	1.195e-103	348.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1101750_5	1313172.YM304_15230	5.31e-173	557.0	COG2141@1|root,COG2141@2|Bacteria,2HG01@201174|Actinobacteria,4CNXD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_1101750_3	1313172.YM304_15220	7.669e-211	666.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_1101750_18	709986.Deima_2887	1.019e-70	256.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_1101750_9	1313172.YM304_15100	2.96e-132	427.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_1101750_13	1313172.YM304_15090	3.824e-114	377.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD2_k127_1101750_12	1313172.YM304_15080	1.223e-118	387.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1101750_6	1313172.YM304_15060	2.265e-161	515.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CMRJ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_1101750_0	1313172.YM304_29640	3.112e-251	784.0	COG0320@1|root,COG0321@1|root,COG0320@2|Bacteria,COG0321@2|Bacteria,2GKD4@201174|Actinobacteria,4CMR4@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
HFD2_k127_1101750_4	1313172.YM304_29650	6.619e-176	573.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_1101750_2	1313172.YM304_29660	1.467e-212	672.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CMT7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_1101750_23	479431.Namu_2294	1.578e-28	133.0	2BBFR@1|root,324Z0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1101750_16	1313172.YM304_29690	3.84e-98	330.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4CN0B@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HFD2_k127_1101750_20	105425.BBPL01000046_gene3061	2.693e-53	191.0	COG0346@1|root,COG0346@2|Bacteria,2IK75@201174|Actinobacteria,2NI6J@228398|Streptacidiphilus	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_1101750_19	219305.MCAG_02917	1.506e-55	200.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4D9KN@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_1101750_22	1313172.YM304_29720	5.579e-40	156.0	COG1846@1|root,COG1846@2|Bacteria,2H64I@201174|Actinobacteria,4CNCT@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_1101750_11	1313172.YM304_29730	1.269e-119	411.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4CN30@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD2_k127_1111294_10	1313172.YM304_25350	6.338e-37	139.0	COG2236@1|root,COG2236@2|Bacteria,2GN86@201174|Actinobacteria	201174|Actinobacteria	F	phosphoribosyltransferase	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
HFD2_k127_1111294_0	1313172.YM304_25340	0.0	1119.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	pucD	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_1111294_4	1313172.YM304_25330	7.123e-72	245.0	COG2080@1|root,COG2080@2|Bacteria,2GMXT@201174|Actinobacteria	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_1111294_2	1313172.YM304_25320	1.055e-93	315.0	COG4630@1|root,COG4630@2|Bacteria,2I33J@201174|Actinobacteria	201174|Actinobacteria	F	Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HFD2_k127_1111294_3	504728.K649_10090	1.461e-89	302.0	COG2326@1|root,COG2326@2|Bacteria,1WKEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HFD2_k127_1111294_5	1229780.BN381_20132	5.589e-66	248.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,3UXHK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_1111294_6	298653.Franean1_3463	6.749e-57	210.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4EU1K@85013|Frankiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_1111294_9	1229780.BN381_20134	4.744e-51	193.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,3UWXI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_1111294_1	1120936.KB907209_gene1792	1.089e-138	451.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
HFD2_k127_1111294_7	1146883.BLASA_2833	4.088e-56	199.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EUCP@85013|Frankiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_1111294_8	1229780.BN381_50085	2.599e-54	192.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,3UX3T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_1155403_6	395493.BegalDRAFT_2052	1.791e-45	169.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,1RY79@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD2_k127_1155403_1	1313172.YM304_15210	5.773e-241	756.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CMUF@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_1155403_2	1313172.YM304_12770	2.801e-167	537.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CNI4@84992|Acidimicrobiia	201174|Actinobacteria	JKL	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HFD2_k127_1155403_3	1313172.YM304_12850	5.627e-93	312.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CN17@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD2_k127_1155403_0	1313172.YM304_12860	1.661e-244	762.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CMTC@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_1155403_5	1313172.YM304_12870	6.93e-64	228.0	COG1414@1|root,COG1414@2|Bacteria,2HGKQ@201174|Actinobacteria,4CP2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_1155403_4	1313172.YM304_12940	3.812e-65	232.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HFD2_k127_1155403_7	1454010.JEOE01000003_gene270	4.514e-09	64.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4F0HK@85016|Cellulomonadaceae	201174|Actinobacteria	CE	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
HFD2_k127_1177773_4	1313172.YM304_23520	7.615e-203	634.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_1177773_3	1313172.YM304_23650	2.11e-239	757.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD2_k127_1177773_11	1313172.YM304_23660	2.655e-64	225.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4CNS4@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HFD2_k127_1177773_1	1313172.YM304_23680	6.825e-297	936.0	COG0150@1|root,COG0151@1|root,COG0150@2|Bacteria,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4CMZB@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD2_k127_1177773_2	1313172.YM304_23690	6.77e-251	782.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CMWP@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
HFD2_k127_1177773_8	1313172.YM304_23700	4.931e-129	418.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4CN60@84992|Acidimicrobiia	84992|Acidimicrobiia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD2_k127_1177773_9	1313172.YM304_23710	6.348e-91	305.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4CN8T@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD2_k127_1177773_0	1313172.YM304_23720	0.0	1082.0	COG0046@1|root,COG1828@1|root,COG0046@2|Bacteria,COG1828@2|Bacteria,2GKG6@201174|Actinobacteria,4CMZH@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_1177773_12	1313172.YM304_23740	4.92e-63	223.0	COG0406@1|root,COG0406@2|Bacteria,2IAPP@201174|Actinobacteria	201174|Actinobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD2_k127_1177773_7	502025.Hoch_4537	1.037e-144	466.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria,2YW6C@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1177773_13	1313172.YM304_23790	2.206e-56	206.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
HFD2_k127_1177773_10	1313172.YM304_23810	4.705e-68	234.0	2DPAW@1|root,331AG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
HFD2_k127_1177773_6	469383.Cwoe_3295	7.542e-168	537.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD2_k127_1177773_14	926569.ANT_22220	5.803e-45	175.0	COG2940@1|root,COG2940@2|Bacteria,2G9DE@200795|Chloroflexi	200795|Chloroflexi	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	-	-	-	-	-	-	-	-	-	SET
HFD2_k127_1177773_5	1313172.YM304_23840	1.207e-186	593.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4CNHB@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_1177773_16	1121877.JQKF01000027_gene2453	1.827e-21	96.0	2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1177773_15	889378.Spiaf_1907	1.132e-21	106.0	COG0697@1|root,COG0697@2|Bacteria,2JAUC@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	rarD	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1194833_2	436229.JOEH01000010_gene5144	1.922e-79	272.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2NF0X@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1194833_8	1408452.JAGZ01000014_gene2333	1.812e-45	177.0	COG0840@1|root,COG4585@1|root,COG0840@2|Bacteria,COG4585@2|Bacteria,2I4F7@201174|Actinobacteria,23D6Q@1762|Mycobacteriaceae	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS
HFD2_k127_1194833_10	1045009.AFXQ01000002_gene1588	6.866e-29	124.0	COG0071@1|root,COG0071@2|Bacteria,2GQGQ@201174|Actinobacteria,1WBR0@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_1194833_9	1313172.YM304_27880	6.185e-42	166.0	COG0589@1|root,COG0589@2|Bacteria,2HF8Z@201174|Actinobacteria,4CNUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_1194833_11	446471.Xcel_2291	7.439e-17	92.0	COG5401@1|root,COG5401@2|Bacteria,2IRST@201174|Actinobacteria,4F4QD@85017|Promicromonosporaceae	201174|Actinobacteria	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1194833_12	405948.SACE_2471	1.337e-08	64.0	2DBEB@1|root,32TXC@2|Bacteria,2IRDQ@201174|Actinobacteria,4E6EI@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1194833_0	1122221.JHVI01000023_gene480	2.67e-162	519.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_1194833_1	1122221.JHVI01000023_gene479	9.585e-109	357.0	COG1028@1|root,COG1028@2|Bacteria	1122221.JHVI01000023_gene479|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1194833_5	1209984.BN978_04120	1.769e-59	214.0	COG2071@1|root,COG2071@2|Bacteria,2IIMU@201174|Actinobacteria,23DC4@1762|Mycobacteriaceae	201174|Actinobacteria	S	Peptidase C26	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C26
HFD2_k127_1194833_3	1313172.YM304_09210	3.46e-77	271.0	COG0204@1|root,COG0204@2|Bacteria,2H2S8@201174|Actinobacteria	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_1194833_7	420324.KI912031_gene2787	5.897e-47	184.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,1JV0P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HFD2_k127_1194833_13	1380390.JIAT01000010_gene3757	1.087e-07	60.0	COG3794@1|root,COG3794@2|Bacteria,2HPH9@201174|Actinobacteria,4CQVK@84995|Rubrobacteria	84995|Rubrobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HFD2_k127_1194833_6	1211815.CBYP010000056_gene3346	9.661e-59	208.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4ERS8@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	dapC	-	2.6.1.1,2.6.1.17	ko:K00812,ko:K10907,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_1196755_0	479432.Sros_3809	3.14e-226	731.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales	201174|Actinobacteria	O	HypF finger	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HFD2_k127_1196755_1	1429046.RR21198_4164	1.805e-156	511.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4FTY3@85025|Nocardiaceae	201174|Actinobacteria	O	AIR synthase related protein, C-terminal domain	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HFD2_k127_1196755_3	1380386.JIAW01000025_gene6804	1.659e-66	233.0	COG0279@1|root,COG0279@2|Bacteria,2GM2Q@201174|Actinobacteria,2362X@1762|Mycobacteriaceae	201174|Actinobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD2_k127_1196755_2	675635.Psed_6371	4.674e-74	258.0	COG0279@1|root,COG0279@2|Bacteria,2GMKE@201174|Actinobacteria	201174|Actinobacteria	G	HupF/HypC family	-	-	-	-	-	-	-	-	-	-	-	-	HupF_HypC,SIS_2
HFD2_k127_1196755_5	469371.Tbis_3220	1.437e-22	105.0	COG0375@1|root,COG0375@2|Bacteria,2IKYY@201174|Actinobacteria,4EF1Y@85010|Pseudonocardiales	201174|Actinobacteria	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HFD2_k127_1196755_4	771875.Ferpe_0943	7.883e-48	179.0	COG0330@1|root,COG0330@2|Bacteria,2GC8F@200918|Thermotogae	200918|Thermotogae	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_1237013_5	1313172.YM304_10030	5.82e-11	64.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4CNXU@84992|Acidimicrobiia	84992|Acidimicrobiia	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_1237013_1	1313172.YM304_10010	2.116e-93	314.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CNUH@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_1237013_0	1313172.YM304_10000	7.406e-98	323.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4CNCR@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_1237013_3	1313172.YM304_09990	1.077e-62	225.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4CN9I@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
HFD2_k127_1237013_2	1313172.YM304_09980	6.964e-92	316.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4CN1N@84992|Acidimicrobiia	84992|Acidimicrobiia	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1237013_4	1313172.YM304_09920	4.052e-61	211.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4CMXZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Electron transfer flavoprotein domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_1266494_1	1283299.AUKG01000002_gene4080	3.21e-80	271.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CR1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_1266494_0	525909.Afer_1025	0.0	1518.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2GKX9@201174|Actinobacteria,4CN7I@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD2_k127_1269825_9	479432.Sros_1800	1.658e-38	155.0	COG3281@1|root,COG3281@2|Bacteria,2IBUS@201174|Actinobacteria,4EIG4@85012|Streptosporangiales	201174|Actinobacteria	G	Aminoglycoside phosphotransferase	-	-	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_1269825_1	479432.Sros_1806	1.12e-193	612.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4EHG3@85012|Streptosporangiales	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
HFD2_k127_1269825_6	208444.JNYY01000020_gene4595	2.529e-79	273.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria,4DY2A@85010|Pseudonocardiales	201174|Actinobacteria	KT	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1269825_5	146922.JOFU01000071_gene7868	1.216e-88	325.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,Sensor
HFD2_k127_1269825_2	479434.Sthe_2199	8.904e-166	548.0	COG2409@1|root,COG2409@2|Bacteria,2G6XZ@200795|Chloroflexi,27XX9@189775|Thermomicrobia	200795|Chloroflexi	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_1269825_4	882.DVU_2935	5.011e-89	301.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M970@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HFD2_k127_1269825_11	1229780.BN381_60087	6.997e-28	120.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HTH_Crp_2,cNMP_binding
HFD2_k127_1269825_13	1313172.YM304_28290	3.806e-19	91.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,PRC
HFD2_k127_1269825_0	1313172.YM304_39270	0.0	1198.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD2_k127_1269825_8	869210.Marky_0943	2.363e-43	172.0	COG0673@1|root,COG0673@2|Bacteria,1WJ56@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG0673 dehydrogenase and related protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_1269825_14	543632.JOJL01000004_gene4193	1.358e-13	85.0	COG4733@1|root,COG4733@2|Bacteria,2I4VD@201174|Actinobacteria,4DHGI@85008|Micromonosporales	201174|Actinobacteria	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1269825_10	1313172.YM304_29760	1.173e-35	156.0	COG2385@1|root,COG2755@1|root,COG3409@1|root,COG2385@2|Bacteria,COG2755@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.4.17.14	ko:K07260,ko:K21449	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02000	1.B.40.2	-	-	Amidase_3,CHAP,ChW,PG_binding_1,SpoIID,VanY
HFD2_k127_1269825_7	525909.Afer_0052	2.085e-75	257.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4CMXC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
HFD2_k127_1269825_12	935839.JAGJ01000004_gene1895	3.06e-23	104.0	COG1670@1|root,COG1670@2|Bacteria,2IFNY@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferases including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_1269825_3	471857.Svir_02130	5.877e-133	432.0	COG2141@1|root,COG2141@2|Bacteria,2GJ66@201174|Actinobacteria,4DZDQ@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM luciferase family oxidoreductase, group 1	yvbT	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_1283144_24	1385520.N802_15460	5.467e-12	70.0	2A0U6@1|root,30NYZ@2|Bacteria,2H2K1@201174|Actinobacteria,4FJAW@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YecM
HFD2_k127_1283144_23	292459.STH526	7.808e-18	97.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia	186801|Clostridia	M	Capsule synthesis protein	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
HFD2_k127_1283144_11	1121381.JNIV01000003_gene3435	4.652e-87	315.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,YARHG,zinc_ribbon_2
HFD2_k127_1283144_13	331869.BAL199_27091	1.535e-71	248.0	COG0684@1|root,COG0684@2|Bacteria,1MUES@1224|Proteobacteria,2U0IC@28211|Alphaproteobacteria,4BQ9S@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Aldolase/RraA	MA20_26380	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD2_k127_1283144_10	1123060.JONP01000002_gene960	3.302e-88	304.0	COG0111@1|root,COG0111@2|Bacteria,1P7J3@1224|Proteobacteria,2TV9K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	MA20_02105	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_1283144_21	1313172.YM304_36780	1.062e-30	127.0	COG1514@1|root,COG1514@2|Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HFD2_k127_1283144_1	1229780.BN381_350050	1.206e-224	743.0	COG1807@1|root,COG1807@2|Bacteria,2GJPU@201174|Actinobacteria	201174|Actinobacteria	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_1283144_2	1068978.AMETH_6690	1.023e-157	507.0	COG1215@1|root,COG1215@2|Bacteria,2GJTE@201174|Actinobacteria,4DYC7@85010|Pseudonocardiales	201174|Actinobacteria	M	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HFD2_k127_1283144_14	926550.CLDAP_26150	2.812e-46	181.0	COG0673@1|root,COG0673@2|Bacteria,2G6E7@200795|Chloroflexi	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_1283144_8	1313172.YM304_30960	1.772e-100	340.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.2.1.96,3.5.1.28	ko:K01227,ko:K01448,ko:K03791,ko:K13277,ko:K17733	ko00511,ko01503,ko02024,map00511,map01503,map02024	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036,ko03110	-	GH19	-	PG_binding_1,YkuD
HFD2_k127_1283144_18	1463936.JOJI01000017_gene7333	4.955e-35	140.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria	201174|Actinobacteria	I	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HFD2_k127_1283144_16	1123023.JIAI01000007_gene1945	1.059e-42	160.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5FV@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1283144_12	1313172.YM304_34390	8.977e-74	270.0	COG1051@1|root,COG1051@2|Bacteria,2GJGZ@201174|Actinobacteria	201174|Actinobacteria	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4916
HFD2_k127_1283144_15	1125971.ASJB01000080_gene7213	6.417e-43	182.0	COG1404@1|root,COG1472@1|root,COG3828@1|root,COG4932@1|root,COG1404@2|Bacteria,COG1472@2|Bacteria,COG3828@2|Bacteria,COG4932@2|Bacteria,2I4SB@201174|Actinobacteria,4EE04@85010|Pseudonocardiales	201174|Actinobacteria	GMO	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,PKD,Peptidase_S8,Ricin_B_lectin
HFD2_k127_1283144_9	1313172.YM304_34380	3.388e-97	334.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_1283144_0	1313172.YM304_34320	7.662e-257	845.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
HFD2_k127_1283144_6	1313172.YM304_34350	7.013e-116	379.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1283144_3	1048339.KB913029_gene2528	9.627e-150	504.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_1283144_20	1380390.JIAT01000010_gene4585	3.584e-32	130.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
HFD2_k127_1283144_7	1313172.YM304_34270	7.216e-113	368.0	COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria,4CMXQ@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HFD2_k127_1283144_17	1298863.AUEP01000007_gene365	1.785e-40	152.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4DSFS@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
HFD2_k127_1283144_4	1298863.AUEP01000007_gene366	1.674e-120	398.0	COG3832@1|root,COG3832@2|Bacteria,2IMFE@201174|Actinobacteria,4DS84@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_1283144_22	1313172.YM304_25800	1.414e-22	107.0	COG0739@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3409@2|Bacteria,2IDIJ@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD2_k127_1283144_25	875328.JDM601_0434	6.319e-05	49.0	2DI8M@1|root,32UAP@2|Bacteria,2GR9W@201174|Actinobacteria,23A0I@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_1283144_5	1313172.YM304_02500	4.972e-119	389.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_1283144_19	351607.Acel_1545	1.937e-32	132.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
HFD2_k127_132332_4	1313172.YM304_21920	6.597e-100	347.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4CNRU@84992|Acidimicrobiia	84992|Acidimicrobiia	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD2_k127_132332_8	1068978.AMETH_1398	9.854e-55	204.0	COG3550@1|root,COG3550@2|Bacteria,2GJ1X@201174|Actinobacteria,4E6YS@85010|Pseudonocardiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HFD2_k127_132332_11	1896.JOAU01000013_gene1809	2.018e-43	168.0	COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria	201174|Actinobacteria	K	peptidase C26	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
HFD2_k127_132332_1	1123320.KB889682_gene2137	1.134e-108	377.0	COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria	201174|Actinobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_132332_15	1298863.AUEP01000001_gene694	1.191e-19	102.0	2C7EM@1|root,2ZQFW@2|Bacteria,2H9WX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_132332_5	1313172.YM304_15460	3.862e-96	323.0	COG4221@1|root,COG4221@2|Bacteria,2I2DY@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_132332_0	1313172.YM304_15480	3.79e-161	519.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria	201174|Actinobacteria	Q	diacylglycerol O-acyltransferase	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_132332_6	1380356.JNIK01000013_gene4128	3.31e-62	237.0	COG2372@1|root,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4ESVK@85013|Frankiales	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HFD2_k127_132332_16	1246995.AFR_06480	1.226e-13	79.0	2EBDG@1|root,335E5@2|Bacteria,2I82Y@201174|Actinobacteria,4DMWZ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_132332_14	935866.JAER01000010_gene4142	3.21e-20	103.0	COG4549@1|root,COG4549@2|Bacteria,2GN9H@201174|Actinobacteria,4DQN7@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unkown function (DUF1775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1775
HFD2_k127_132332_12	1146883.BLASA_0708	9.824e-39	152.0	COG1595@1|root,COG1595@2|Bacteria,2IHWH@201174|Actinobacteria,4EVQ8@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase sigma factor	sigC	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_132332_10	1313172.YM304_15490	2.942e-44	178.0	COG0671@1|root,COG0671@2|Bacteria,2HGAE@201174|Actinobacteria,4CN9F@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_132332_3	1313172.YM304_15500	1.296e-100	335.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4CN3P@84992|Acidimicrobiia	84992|Acidimicrobiia	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
HFD2_k127_132332_7	1313172.YM304_15510	1.115e-61	226.0	COG2267@1|root,COG2267@2|Bacteria,2HGVY@201174|Actinobacteria,4CNX3@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_132332_18	446470.Snas_5781	3.401e-07	60.0	COG5660@1|root,COG5660@2|Bacteria	2|Bacteria	S	Putative zinc-finger	sigC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	zf-HC2
HFD2_k127_132332_2	1313172.YM304_15640	1.774e-107	354.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4CNXR@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_132332_9	1229780.BN381_80237	3.026e-53	196.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1353543_3	1242864.D187_001549	6.911e-177	570.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD2_k127_1353543_7	1254432.SCE1572_42000	4.251e-147	491.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	HATPase_c_2,HTH_Crp_2,cNMP_binding
HFD2_k127_1353543_6	66897.DJ64_14855	1.914e-159	517.0	COG4310@1|root,COG4310@2|Bacteria,2GK72@201174|Actinobacteria	201174|Actinobacteria	S	winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47,Peptidase_M28
HFD2_k127_1353543_4	864702.OsccyDRAFT_4169	1.593e-176	565.0	COG4976@1|root,COG4976@2|Bacteria,1GQBZ@1117|Cyanobacteria,1HHY0@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
HFD2_k127_1353543_17	67352.JODS01000045_gene4105	9.801e-38	156.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HFD2_k127_1353543_2	1122604.JONR01000047_gene2049	1.649e-182	579.0	COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria,1X2Y1@135614|Xanthomonadales	135614|Xanthomonadales	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	-	-	-	-	-	-	-	-	-	-	HMG-CoA_red
HFD2_k127_1353543_8	882083.SacmaDRAFT_5691	1.797e-125	417.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4E14S@85010|Pseudonocardiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_1353543_9	882083.SacmaDRAFT_5690	7.339e-120	409.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4DYYG@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_1353543_11	1068978.AMETH_0142	7.059e-110	362.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4DZD5@85010|Pseudonocardiales	201174|Actinobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_1353543_1	1068978.AMETH_0143	3.983e-246	777.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DZ2U@85010|Pseudonocardiales	201174|Actinobacteria	I	AMP-forming long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD2_k127_1353543_15	1068978.AMETH_0144	7.974e-98	332.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E1TV@85010|Pseudonocardiales	201174|Actinobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_1353543_12	1068978.AMETH_0145	1.501e-109	363.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DY02@85010|Pseudonocardiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_1353543_0	317936.Nos7107_1729	9.012e-248	812.0	COG2374@1|root,COG2931@1|root,COG3386@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,1GHDU@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM 5'-nucleotidase, C-terminal domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Calx-beta,Exo_endo_phos,HemolysinCabind,LTD
HFD2_k127_1353543_13	196162.Noca_0146	8.394e-109	379.0	COG2304@1|root,COG2304@2|Bacteria,2IDJM@201174|Actinobacteria	201174|Actinobacteria	V	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
HFD2_k127_1353543_14	114615.BRADO4820	8.3e-103	349.0	COG2072@1|root,COG2072@2|Bacteria,1R72X@1224|Proteobacteria,2VBDB@28211|Alphaproteobacteria,3JX8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
HFD2_k127_1353543_18	443143.GM18_1651	3.617e-33	145.0	COG3919@1|root,COG3919@2|Bacteria,1N13P@1224|Proteobacteria,42WGT@68525|delta/epsilon subdivisions,2WRKR@28221|Deltaproteobacteria,43VRY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
HFD2_k127_1353543_5	292459.STH518	1.602e-167	548.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_1353543_10	710686.Mycsm_00934	9.314e-113	398.0	COG2197@1|root,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria,23F97@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_1353543_16	543632.JOJL01000006_gene9601	4.285e-62	236.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD2_k127_1353543_19	1440053.JOEI01000012_gene4362	1.944e-23	114.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
HFD2_k127_1353543_20	1226322.HMPREF1545_03635	0.0003797	46.0	COG1366@1|root,COG1366@2|Bacteria,1UGSP@1239|Firmicutes,25PBH@186801|Clostridia,2N7KY@216572|Oscillospiraceae	186801|Clostridia	T	STAS domain	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS_2
HFD2_k127_1375153_2	1279017.AQYJ01000026_gene73	1.386e-05	53.0	2DXTJ@1|root,346GW@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1375153_0	882083.SacmaDRAFT_5159	0.0	1488.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HFD2_k127_1375153_1	675635.Psed_3042	6.444e-171	541.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HFD2_k127_141012_3	443143.GM18_0019	1.125e-104	347.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HFD2_k127_141012_4	1313172.YM304_03240	5.913e-93	315.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_141012_1	1313172.YM304_03250	1.464e-158	510.0	COG1804@1|root,COG1804@2|Bacteria,2IB98@201174|Actinobacteria	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD2_k127_141012_0	1313172.YM304_03280	0.0	1025.0	COG0383@1|root,COG0383@2|Bacteria,2GM02@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycoside hydrolase, family 38	ama2	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
HFD2_k127_141012_2	675635.Psed_0333	1.453e-135	443.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4E039@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_141012_5	390235.PputW619_4600	1.906e-30	128.0	COG1443@1|root,COG1443@2|Bacteria,1P8AM@1224|Proteobacteria,1RQA3@1236|Gammaproteobacteria,1YVDR@136845|Pseudomonas putida group	1236|Gammaproteobacteria	I	Nudix hydrolase	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0565	NUDIX
HFD2_k127_141012_7	469371.Tbis_2594	3.455e-10	64.0	COG0011@1|root,COG0011@2|Bacteria,2HS4V@201174|Actinobacteria,4ECDI@85010|Pseudonocardiales	201174|Actinobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
HFD2_k127_1557247_3	1313172.YM304_28830	9.468e-140	451.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CMX2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_1557247_6	1313172.YM304_28820	3.488e-84	298.0	COG0741@1|root,COG0741@2|Bacteria,2IF18@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HFD2_k127_1557247_1	1313172.YM304_28810	1.158e-220	691.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CMT7@84992|Acidimicrobiia	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_1557247_0	1313172.YM304_28760	5.418e-270	874.0	COG0439@1|root,COG4770@1|root,COG0439@2|Bacteria,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CMS3@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HFD2_k127_1557247_8	436229.JOEH01000034_gene3549	5.515e-39	161.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,2NGJ6@228398|Streptacidiphilus	201174|Actinobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
HFD2_k127_1557247_4	1313172.YM304_28740	2.51e-94	320.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HFD2_k127_1557247_9	1121033.AUCF01000020_gene644	4.215e-17	87.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQTN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HFD2_k127_1557247_2	1229780.BN381_10111	2.134e-148	478.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,3UWQW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_1557247_7	1229780.BN381_10112	3.184e-79	267.0	COG1898@1|root,COG1898@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	rfbC	-	1.1.1.133,4.2.1.46,5.1.3.13	ko:K00067,ko:K01710,ko:K01790	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R02777,R06513,R06514	RC00182,RC00402,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD2_k127_1557247_5	1229780.BN381_10113	9.753e-92	305.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,3UWG6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	strE	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_1559182_5	1313172.YM304_10420	2.427e-24	104.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD2_k127_1559182_1	1313172.YM304_10360	1.378e-214	683.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CMS7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HFD2_k127_1559182_3	1313172.YM304_10350	1.644e-190	604.0	COG0498@1|root,COG0498@2|Bacteria,2GIRY@201174|Actinobacteria	201174|Actinobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HFD2_k127_1559182_4	1313172.YM304_10340	4.099e-188	597.0	COG0460@1|root,COG2844@1|root,COG0460@2|Bacteria,COG2844@2|Bacteria,2GIX9@201174|Actinobacteria,4CMW6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_1559182_2	1313172.YM304_10310	1.995e-207	653.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CMVX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD2_k127_1559182_0	1313172.YM304_10300	2.001e-217	689.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4CNAI@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HFD2_k127_1559182_6	1206735.BAGG01000019_gene805	0.0003132	49.0	COG1961@1|root,COG1961@2|Bacteria,2GNGI@201174|Actinobacteria,4FVZ0@85025|Nocardiaceae	201174|Actinobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_1560542_2	1313172.YM304_20800	1.314e-120	391.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD2_k127_1560542_1	1313172.YM304_20810	8.584e-162	531.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4CMTH@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_1560542_4	1313172.YM304_20820	4.236e-116	383.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4CN2V@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_1560542_5	1313172.YM304_20830	1.744e-58	217.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4CN15@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HFD2_k127_1560542_0	1313172.YM304_20840	2.333e-179	578.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CMW7@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HFD2_k127_1560542_6	1313172.YM304_20850	1.954e-39	154.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4CNZT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Methylpurine-DNA glycosylase (MPG)	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HFD2_k127_1560542_3	452637.Oter_2683	1.639e-119	404.0	COG0162@1|root,COG0162@2|Bacteria,46UVG@74201|Verrucomicrobia,3K7IA@414999|Opitutae	414999|Opitutae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HFD2_k127_1577837_27	1032480.MLP_41930	3.51e-08	58.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DNWQ@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	ddc	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
HFD2_k127_1577837_10	1229780.BN381_50052	2.812e-97	324.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,3UXS7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1577837_20	1313172.YM304_16550	5.357e-36	146.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_1577837_22	1211815.CBYP010000012_gene467	2.059e-27	120.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	pac	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HFD2_k127_1577837_5	309801.trd_A0430	3.387e-145	473.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	2|Bacteria	E	glutamine synthetase	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_1577837_7	1205680.CAKO01000008_gene4205	1.332e-127	429.0	COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2TTH5@28211|Alphaproteobacteria,2JW3I@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_1577837_11	1313172.YM304_16540	2.135e-89	300.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CN2D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HFD2_k127_1577837_13	926550.CLDAP_01610	2.268e-80	302.0	COG1680@1|root,COG1680@2|Bacteria,2G7A9@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_1577837_8	1229172.JQFA01000004_gene1611	3.769e-124	418.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H8H6@1150|Oscillatoriales	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9
HFD2_k127_1577837_19	1384054.N790_10135	2.194e-36	149.0	COG0666@1|root,COG0666@2|Bacteria,1NC5F@1224|Proteobacteria	1224|Proteobacteria	S	COG0666 FOG Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD2_k127_1577837_26	10181.XP_004836926.1	9.845e-09	66.0	COG0252@1|root,KOG0503@2759|Eukaryota,38D57@33154|Opisthokonta,3BFKQ@33208|Metazoa,3CR8B@33213|Bilateria,48AUR@7711|Chordata,490WY@7742|Vertebrata,3J272@40674|Mammalia,35G1A@314146|Euarchontoglires,4Q3IK@9989|Rodentia	33208|Metazoa	E	60 kDa lysophospholipase	ASPG	GO:0003674,GO:0003824,GO:0003847,GO:0004067,GO:0004620,GO:0004622,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016053,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0016810,GO:0016811,GO:0019637,GO:0019752,GO:0032787,GO:0034641,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0052689,GO:0071704,GO:0072329,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	3.1.1.47,3.1.1.5,3.5.1.1	ko:K13278	-	-	-	-	ko00000,ko01000	-	-	-	Ank_2,Ank_4,Ank_5,Asparaginase
HFD2_k127_1577837_21	479432.Sros_8781	2.132e-31	130.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4EJSS@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1577837_24	68260.JOAY01000006_gene5013	1.271e-20	97.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_1577837_6	67373.JOBF01000012_gene4002	3.422e-138	453.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD2_k127_1577837_18	1144310.PMI07_005658	3.226e-54	194.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_1577837_12	1122963.AUHB01000003_gene3831	6.038e-84	286.0	COG0289@1|root,COG0289@2|Bacteria,1R4EU@1224|Proteobacteria,2U3UV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HFD2_k127_1577837_4	1313172.YM304_16520	1.024e-158	511.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4CMPS@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HFD2_k127_1577837_15	1313172.YM304_16510	1.854e-65	234.0	COG0558@1|root,COG0558@2|Bacteria,2HGCB@201174|Actinobacteria,4CNAE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_1577837_3	1313172.YM304_16500	6.919e-189	599.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_1577837_2	1229780.BN381_80302	1.286e-206	668.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD2_k127_1577837_1	1313172.YM304_16400	5.526e-267	830.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CMS5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HFD2_k127_1577837_9	1313172.YM304_16390	2.807e-118	387.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4CN0H@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_1577837_23	1280949.HAD_17176	2.779e-26	118.0	COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,2TVDN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	acyl-L-homoserine-lactone lactonohydrolase activity	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_1577837_14	404589.Anae109_0474	9.853e-67	236.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,43A9Z@68525|delta/epsilon subdivisions,2X37W@28221|Deltaproteobacteria,2YV2G@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
HFD2_k127_1577837_16	1123320.KB889681_gene2598	5.803e-58	211.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_1577837_17	1313172.YM304_42260	1.091e-54	194.0	COG0662@1|root,COG0662@2|Bacteria,2H8T0@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_1577837_0	1313172.YM304_42250	1.22e-278	872.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CNGA@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	Protein synonym hydantoin utilization protein A	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD2_k127_1635856_4	1206741.BAFX01000082_gene6168	1.939e-23	109.0	COG2197@1|root,COG2197@2|Bacteria,2GPKD@201174|Actinobacteria,4FYKY@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GerE
HFD2_k127_1635856_0	1313172.YM304_16570	2.625e-132	439.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4CNXT@84992|Acidimicrobiia	84992|Acidimicrobiia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_1635856_3	208444.JNYY01000043_gene3279	6.635e-44	171.0	COG0346@1|root,COG0346@2|Bacteria,2GRGB@201174|Actinobacteria,4E5WM@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD2_k127_1635856_1	1123320.KB889686_gene602	5.626e-119	396.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria	201174|Actinobacteria	E	decarboxylase	ddc	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HFD2_k127_1635856_2	1229780.BN381_50052	8.477e-85	286.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,3UXS7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1642764_10	1122939.ATUD01000002_gene1481	1.252e-66	237.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4CQ63@84995|Rubrobacteria	84995|Rubrobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD2_k127_1642764_12	1313172.YM304_36480	1.955e-61	225.0	COG1295@1|root,COG1295@2|Bacteria,2HG9R@201174|Actinobacteria,4CN87@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
HFD2_k127_1642764_5	1313172.YM304_36470	7.677e-103	338.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_1642764_17	644283.Micau_5572	1.316e-22	104.0	COG1595@1|root,COG1595@2|Bacteria,2IP48@201174|Actinobacteria,4DE61@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1642764_2	1313172.YM304_36450	1.246e-146	472.0	COG3491@1|root,COG3491@2|Bacteria,2IFWJ@201174|Actinobacteria	201174|Actinobacteria	C	non-haem dioxygenase in morphine synthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HFD2_k127_1642764_3	1313172.YM304_36430	7.239e-109	372.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_1642764_6	1313172.YM304_36410	1.279e-93	316.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria	201174|Actinobacteria	S	Neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD2_k127_1642764_7	1313172.YM304_36390	7.008e-90	312.0	COG2311@1|root,COG2311@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF1624,DUF418
HFD2_k127_1642764_8	1313172.YM304_36400	3.451e-89	304.0	COG0787@1|root,COG0787@2|Bacteria,2GJJX@201174|Actinobacteria	201174|Actinobacteria	M	Alanine racemase	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HFD2_k127_1642764_13	446470.Snas_5222	1.251e-46	174.0	2DMC7@1|root,32J0V@2|Bacteria,2I81N@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
HFD2_k127_1642764_4	1157638.KB892174_gene322	5.706e-106	363.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_1642764_11	994479.GL877879_gene5201	1.793e-61	231.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4DZA3@85010|Pseudonocardiales	201174|Actinobacteria	S	Creatinine amidohydrolase	mftE	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HFD2_k127_1642764_15	994479.GL877883_gene7373	2.171e-32	134.0	COG1309@1|root,COG1309@2|Bacteria,2IIK3@201174|Actinobacteria,4E2YS@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HFD2_k127_1642764_1	525368.HMPREF0591_3920	3.406e-152	500.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,234KQ@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_1642764_16	1229780.BN381_250063	8.165e-28	126.0	COG2086@1|root,COG2086@2|Bacteria,2GSWB@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_1642764_14	994479.GL877879_gene5205	1.712e-37	159.0	COG2440@1|root,COG2440@2|Bacteria,2IQVY@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO,Fer4_9
HFD2_k127_1642764_0	1229780.BN381_250065	1.305e-175	561.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,FAD_oxidored,Pyr_redox_2
HFD2_k127_1642764_9	882083.SacmaDRAFT_1199	5.285e-72	253.0	COG2025@1|root,COG2025@2|Bacteria,2IIKX@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_1764544_13	316274.Haur_3900	1.381e-68	253.0	COG1216@1|root,COG1216@2|Bacteria,2GBIQ@200795|Chloroflexi,374ZU@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1764544_15	926550.CLDAP_39760	2.447e-60	222.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_1764544_11	1121406.JAEX01000001_gene467	8.994e-87	299.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42Q4Y@68525|delta/epsilon subdivisions,2WKZT@28221|Deltaproteobacteria,2M8BB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_1764544_21	706587.Desti_4861	3.195e-16	88.0	COG0500@1|root,COG0500@2|Bacteria,1QUSR@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_1764544_4	1380394.JADL01000011_gene4041	2.726e-209	677.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2JPN7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HFD2_k127_1764544_18	1313172.YM304_13970	7.81e-52	201.0	2FJ53@1|root,34AVA@2|Bacteria,2H8CM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1764544_16	1313172.YM304_13980	5.839e-57	208.0	COG1184@1|root,COG1184@2|Bacteria,2H70W@201174|Actinobacteria	201174|Actinobacteria	J	Initiation factor 2 subunit family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1764544_20	1123023.JIAI01000001_gene6005	6.801e-39	160.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria,4E6D0@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_1764544_9	298654.FraEuI1c_5932	9.259e-143	480.0	COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD2_k127_1764544_7	1313172.YM304_14020	3.861e-155	505.0	COG0388@1|root,COG0388@2|Bacteria,2HGYE@201174|Actinobacteria,4CNYQ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Carbon-nitrogen hydrolase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
HFD2_k127_1764544_3	1313172.YM304_14030	8.92e-220	692.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HFD2_k127_1764544_0	1313172.YM304_14040	3.386e-262	813.0	COG1012@1|root,COG1012@2|Bacteria,2HF8M@201174|Actinobacteria,4CMWC@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_1764544_6	1380390.JIAT01000010_gene4543	1.079e-167	532.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4CPAN@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_1764544_12	1246995.AFR_27570	1.736e-71	255.0	COG0600@1|root,COG0600@2|Bacteria,2HDX7@201174|Actinobacteria,4DIFP@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_1764544_10	1313172.YM304_14070	9.625e-111	389.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4CN3G@84992|Acidimicrobiia	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_1764544_14	1313172.YM304_14080	9.787e-65	233.0	COG0600@1|root,COG0600@2|Bacteria,2IFIB@201174|Actinobacteria	201174|Actinobacteria	P	inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_1764544_8	298654.FraEuI1c_5924	3.337e-154	499.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_1764544_17	765420.OSCT_2526	3.853e-55	206.0	COG0697@1|root,COG0697@2|Bacteria,2G99P@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1764544_1	29306.JOBE01000076_gene1837	7.757e-259	811.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD2_k127_1764544_5	1313172.YM304_26900	7.211e-179	564.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_1764544_2	1380347.JNII01000005_gene3211	7.835e-225	706.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4ETTU@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55,4.1.1.64	ko:K00596,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_1764544_19	1313172.YM304_14280	2.117e-41	154.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	mcl2	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI,PEP-utilizers_C
HFD2_k127_1819185_6	330214.NIDE1131	7.676e-113	371.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HFD2_k127_1819185_5	2074.JNYD01000002_gene5411	2.557e-116	381.0	COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria,4EED5@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD2_k127_1819185_1	656024.FsymDg_0028	5.589e-175	560.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4ESCB@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_1819185_16	326424.FRAAL3575	3.184e-38	152.0	2A84P@1|root,30X5E@2|Bacteria,2IN6P@201174|Actinobacteria,4EWIK@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1819185_11	356851.JOAN01000001_gene3320	4.391e-75	269.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4D9V1@85008|Micromonosporales	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_1819185_19	1157637.KB892094_gene3007	4.059e-26	115.0	COG1595@1|root,COG1595@2|Bacteria,2GNBE@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_1819185_13	1089544.KB912942_gene2674	3.854e-63	229.0	COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_1819185_10	1032480.MLP_11920	3.46e-85	287.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4DQTX@85009|Propionibacteriales	201174|Actinobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HFD2_k127_1819185_12	68170.KL590473_gene4634	1.542e-74	269.0	COG1011@1|root,COG1011@2|Bacteria,2IBB1@201174|Actinobacteria,4E2YG@85010|Pseudonocardiales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_1819185_7	1120934.KB894431_gene6379	4.024e-107	357.0	COG2378@1|root,COG2378@2|Bacteria,2GKFU@201174|Actinobacteria,4DYQY@85010|Pseudonocardiales	201174|Actinobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HFD2_k127_1819185_17	1463841.JOIR01000022_gene3273	1.627e-37	151.0	COG1576@1|root,COG1576@2|Bacteria	2|Bacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD2_k127_1819185_2	536019.Mesop_2071	1.945e-153	491.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2VGM8@28211|Alphaproteobacteria,43IHZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the proline racemase family	-	-	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
HFD2_k127_1819185_18	1048339.KB913029_gene1934	3.13e-37	147.0	COG4747@1|root,COG4747@2|Bacteria,2GZWK@201174|Actinobacteria	201174|Actinobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1819185_8	326424.FRAAL3985	7.863e-96	328.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1819185_3	1032480.MLP_26650	3.808e-142	470.0	COG2185@1|root,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mgm	-	5.4.99.4	ko:K20450	ko00760,ko01120,map00760,map01120	-	R03908	RC01024	ko00000,ko00001,ko01000	-	-	-	B12-binding
HFD2_k127_1819185_9	525904.Tter_0396	1.154e-88	302.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_1819185_15	1133849.O3I_022210	1.737e-39	157.0	2F842@1|root,340HG@2|Bacteria,2I5EB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1819185_22	1408823.AXUS01000017_gene1076	6.187e-05	52.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,24Q6W@186801|Clostridia,25RJ6@186804|Peptostreptococcaceae	186801|Clostridia	T	anti-sigma B factor	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD2_k127_1819185_14	685727.REQ_09270	3.676e-54	202.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4G5ZJ@85025|Nocardiaceae	201174|Actinobacteria	K	Sigma-70 region 3	sigF	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_1819185_4	1123320.KB889719_gene7285	3.986e-138	453.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD2_k127_1819185_21	1313172.YM304_37580	2.593e-06	55.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,SpoIIE
HFD2_k127_1819185_0	1123392.AQWL01000002_gene1698	3.009e-184	589.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KS0K@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_1838220_6	1229780.BN381_290076	1.788e-92	310.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,3UWCQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_1838220_14	1183438.GKIL_0709	1.009e-21	102.0	COG2764@1|root,COG2764@2|Bacteria,1G8SR@1117|Cyanobacteria	1117|Cyanobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_1838220_4	1313172.YM304_24920	9.225e-125	413.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CMZU@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_1838220_10	1313172.YM304_24910	3.132e-53	198.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4CNBA@84992|Acidimicrobiia	84992|Acidimicrobiia	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HFD2_k127_1838220_0	1313172.YM304_24900	3.738e-286	885.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD2_k127_1838220_12	1313172.YM304_27860	4.63e-37	161.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4CNDI@84992|Acidimicrobiia	84992|Acidimicrobiia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_1838220_18	994479.GL877879_gene4479	1.267e-06	53.0	COG1011@1|root,COG1011@2|Bacteria,2GN5U@201174|Actinobacteria,4E03B@85010|Pseudonocardiales	201174|Actinobacteria	S	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD2_k127_1838220_11	66377.JOBH01000007_gene2146	7.125e-49	191.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_1838220_2	1313172.YM304_24890	4.948e-165	541.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CMY1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HFD2_k127_1838220_5	1313172.YM304_24880	3.4e-97	327.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4CN3D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD2_k127_1838220_7	1313172.YM304_24870	1.735e-83	288.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4CN67@84992|Acidimicrobiia	84992|Acidimicrobiia	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD2_k127_1838220_8	1313172.YM304_24850	9.557e-78	269.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4CN5Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HFD2_k127_1838220_3	1035308.AQYY01000001_gene1467	7.982e-135	440.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD2_k127_1838220_1	284031.JNXD01000003_gene3754	1.109e-167	534.0	COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria	201174|Actinobacteria	G	PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HFD2_k127_1838220_16	1313172.YM304_24830	5.324e-09	64.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD2_k127_1838220_9	1313172.YM304_26430	3.463e-55	207.0	COG0457@1|root,COG0457@2|Bacteria,2HGAM@201174|Actinobacteria,4CNA6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1841700_15	1146883.BLASA_1347	6.321e-11	67.0	2DXTJ@1|root,346GW@2|Bacteria,2H9GA@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1841700_16	1313172.YM304_37590	1.178e-09	65.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	ANTAR,MEDS,PAS_3,STAS,STAS_2
HFD2_k127_1841700_4	1283283.ATXA01000001_gene1082	1.523e-133	438.0	COG1118@1|root,COG1118@2|Bacteria,2I3KJ@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0015698,GO:0016020,GO:0040007,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072348	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE,TOBE_3
HFD2_k127_1841700_7	1394178.AWOO02000026_gene5111	5.056e-98	329.0	COG4208@1|root,COG4208@2|Bacteria,2I5NF@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD2_k127_1841700_6	1394178.AWOO02000026_gene5112	2.413e-101	339.0	COG0555@1|root,COG0555@2|Bacteria,2I4C5@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
HFD2_k127_1841700_5	1394178.AWOO02000026_gene5113	4.369e-125	408.0	COG1613@1|root,COG1613@2|Bacteria,2GJIK@201174|Actinobacteria	201174|Actinobacteria	P	sulfate ABC transporter	subI	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HFD2_k127_1841700_13	1283299.AUKG01000003_gene289	5.054e-42	160.0	COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria,4CQ7H@84995|Rubrobacteria	84995|Rubrobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_1841700_12	1238186.AOCN01000011_gene1380	6.128e-44	170.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4FNCP@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_1841700_10	1301098.PKB_2810	1.248e-71	252.0	COG1028@1|root,COG1028@2|Bacteria,1RFGR@1224|Proteobacteria,1S4S4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1841700_11	1122939.ATUD01000011_gene2281	5.294e-65	253.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4CRZW@84995|Rubrobacteria	84995|Rubrobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1841700_1	1298863.AUEP01000004_gene2180	2.082e-192	610.0	COG0001@1|root,COG0001@2|Bacteria,2HBVS@201174|Actinobacteria,4DU4P@85009|Propionibacteriales	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_1841700_8	1313172.YM304_31140	8.283e-92	321.0	COG0842@1|root,COG0842@2|Bacteria,2ISVA@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_1841700_9	1313172.YM304_31130	5.116e-88	308.0	COG0842@1|root,COG0842@2|Bacteria,2IPQ3@201174|Actinobacteria	201174|Actinobacteria	U	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_1841700_3	1313172.YM304_31120	1.279e-134	438.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CP50@84992|Acidimicrobiia	84992|Acidimicrobiia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_1841700_14	1313172.YM304_33210	1.716e-25	112.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HFD2_k127_1841700_0	1313172.YM304_33170	4.299e-207	672.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CMRI@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD2_k127_1841700_2	1313172.YM304_33140	1.865e-137	443.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
HFD2_k127_1844502_21	1313172.YM304_28430	3.506e-44	162.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4CMTB@84992|Acidimicrobiia	84992|Acidimicrobiia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HFD2_k127_1844502_16	1313172.YM304_28470	4.84e-85	301.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	ASH,PQQ_3
HFD2_k127_1844502_25	1229780.BN381_10201	6.36e-24	108.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HFD2_k127_1844502_4	1313172.YM304_28490	2.124e-209	659.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CMU2@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_1844502_2	1313172.YM304_28500	4.53e-269	855.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1844502_18	1313172.YM304_28510	2.951e-52	194.0	COG1266@1|root,COG1266@2|Bacteria,2H0BD@201174|Actinobacteria,4CNBE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_1844502_0	1313172.YM304_28530	2.348e-297	928.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CMRD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD2_k127_1844502_24	1313172.YM304_28540	1.782e-35	141.0	COG0526@1|root,COG0526@2|Bacteria,2H7FG@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1844502_1	1313172.YM304_28560	2.767e-286	914.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4CN7G@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HFD2_k127_1844502_7	1313172.YM304_28580	3.625e-164	528.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Polysacc_synt,Polysacc_synt_3
HFD2_k127_1844502_5	1313172.YM304_28590	4.514e-175	557.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria,4CMT5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_1844502_14	1313172.YM304_28600	1.008e-86	307.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_1844502_10	1313172.YM304_28610	3.365e-115	381.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CN0F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HFD2_k127_1844502_12	1313172.YM304_28620	3.698e-97	326.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4CN6I@84992|Acidimicrobiia	84992|Acidimicrobiia	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_1844502_9	1313172.YM304_28630	2.36e-124	410.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4CMYG@84992|Acidimicrobiia	84992|Acidimicrobiia	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_1844502_22	1313172.YM304_28640	1.66e-42	167.0	2968S@1|root,2ZTIT@2|Bacteria,2HEBZ@201174|Actinobacteria,4CNCH@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1844502_8	1313172.YM304_28650	2.481e-144	470.0	COG0438@1|root,COG0438@2|Bacteria,2GMI6@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
HFD2_k127_1844502_20	365528.KB891219_gene1134	2.038e-46	188.0	COG0438@1|root,COG0438@2|Bacteria,2IJX1@201174|Actinobacteria,4EV7B@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_1844502_11	1313172.YM304_28670	2.769e-113	376.0	COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4CNQH@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_1844502_19	797209.ZOD2009_10355	1.708e-50	188.0	arCOG13341@1|root,arCOG13341@2157|Archaea,2XXWE@28890|Euryarchaeota,23WKG@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1844502_23	1056816.JAFQ01000004_gene2661	1.334e-37	146.0	COG0454@1|root,COG0456@2|Bacteria,2IFM9@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HFD2_k127_1844502_27	1121949.AQXT01000002_gene1266	0.0005261	46.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2UNSV@28211|Alphaproteobacteria,43ZQ0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase isomerase family protein	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_1844502_3	247633.GP2143_17446	1.711e-238	742.0	COG1960@1|root,COG1960@2|Bacteria,1MWUU@1224|Proteobacteria	1224|Proteobacteria	I	acyl-CoA dehydrogenase	MA20_16360	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1844502_6	247633.GP2143_17451	2.648e-168	549.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,1S3A0@1236|Gammaproteobacteria,1JA5F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_1844502_15	1313172.YM304_28700	5.927e-86	295.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4CN33@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HFD2_k127_1844502_17	103733.JNYO01000006_gene1708	1.098e-66	230.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E023@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_1873720_39	1123070.KB899261_gene2133	0.0001189	51.0	COG1028@1|root,COG1028@2|Bacteria,46SNA@74201|Verrucomicrobia,2ITSE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_1873720_5	479432.Sros_9336	4.934e-137	445.0	COG3386@1|root,COG3386@2|Bacteria,2GIW1@201174|Actinobacteria,4EQS2@85012|Streptosporangiales	201174|Actinobacteria	G	SMP-30/Gluconolaconase/LRE-like region	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_1873720_38	28444.JODQ01000001_gene2626	1.234e-06	53.0	29ID5@1|root,305AB@2|Bacteria,2HUZ9@201174|Actinobacteria,4EQBY@85012|Streptosporangiales	201174|Actinobacteria	S	MT0933-like antitoxin protein	-	-	-	-	-	-	-	-	-	-	-	-	MT0933_antitox
HFD2_k127_1873720_24	591159.ACEZ01000201_gene2517	4.997e-54	201.0	COG3266@1|root,COG3266@2|Bacteria,2HMYI@201174|Actinobacteria	201174|Actinobacteria	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_1873720_14	1169143.KB911046_gene317	1.706e-87	299.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,1K3V2@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_1873720_18	91464.S7335_2539	1.634e-69	244.0	COG1940@1|root,COG1940@2|Bacteria,1G11A@1117|Cyanobacteria,1GZ0N@1129|Synechococcus	1117|Cyanobacteria	G	Transcriptional regulator sugar kinase	xylR	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_1873720_22	1122604.JONR01000007_gene2914	7.555e-57	203.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1X5XQ@135614|Xanthomonadales	135614|Xanthomonadales	S	EVE domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD2_k127_1873720_25	1449976.KALB_7180	4.023e-52	192.0	COG0243@1|root,COG0243@2|Bacteria,2GJ62@201174|Actinobacteria,4E2T0@85010|Pseudonocardiales	201174|Actinobacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_1873720_31	1385519.N801_05280	2.037e-26	114.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3
HFD2_k127_1873720_16	66897.DJ64_33655	2.347e-70	249.0	COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter DMT superfamily	pecM	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
HFD2_k127_1873720_27	1123320.KB889664_gene1141	9.769e-47	173.0	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_1873720_33	290397.Adeh_0068	6.326e-12	76.0	COG2755@1|root,COG2755@2|Bacteria,1PS6U@1224|Proteobacteria,43315@68525|delta/epsilon subdivisions,2WXTN@28221|Deltaproteobacteria,2YY6Z@29|Myxococcales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_1873720_15	1206741.BAFX01000185_gene7589	1.645e-75	269.0	COG0265@1|root,COG0265@2|Bacteria,2GJJ3@201174|Actinobacteria,4FWGG@85025|Nocardiaceae	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_1873720_13	35703.DQ02_01585	8.16e-94	321.0	COG0078@1|root,COG0078@2|Bacteria,1N4DE@1224|Proteobacteria,1RSHV@1236|Gammaproteobacteria,3WY1J@544|Citrobacter	1236|Gammaproteobacteria	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
HFD2_k127_1873720_35	575609.HMPREF0629_01011	1.672e-08	60.0	COG1989@1|root,COG1989@2|Bacteria	2|Bacteria	NOU	aspartic-type endopeptidase activity	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD2_k127_1873720_36	452863.Achl_2634	4.477e-08	57.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HFD2_k127_1873720_34	1150398.JIBJ01000005_gene3335	1.548e-08	62.0	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_1873720_29	68170.KL590477_gene2205	1.971e-36	157.0	COG4655@1|root,COG4655@2|Bacteria,2IGK1@201174|Actinobacteria	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD2_k127_1873720_30	1151119.KB895490_gene2180	1.425e-33	140.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_1873720_19	1380393.JHVP01000003_gene1143	4.071e-62	237.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4EVMD@85013|Frankiales	201174|Actinobacteria	D	Evidence 2b Function of strongly homologous gene	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
HFD2_k127_1873720_2	685727.REQ_18410	3.761e-162	524.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FUYS@85025|Nocardiaceae	201174|Actinobacteria	U	Type II/IV secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD2_k127_1873720_20	471852.Tcur_1851	4.735e-62	244.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
HFD2_k127_1873720_26	1292020.H483_0115360	8.841e-51	197.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_1873720_7	1172188.KB911820_gene2447	2.192e-124	421.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4FFTR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
HFD2_k127_1873720_8	1313172.YM304_33260	8.524e-123	402.0	COG1226@1|root,COG3273@1|root,COG1226@2|Bacteria,COG3273@2|Bacteria,2HGEC@201174|Actinobacteria,4CNCJ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HFD2_k127_1873720_23	1382303.JPOM01000001_gene1323	4.424e-55	204.0	COG2082@1|root,COG2082@2|Bacteria,1P7TI@1224|Proteobacteria,2U1XP@28211|Alphaproteobacteria,2KEZG@204458|Caulobacterales	204458|Caulobacterales	H	Precorrin-8x methylmutase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1873720_17	1122138.AQUZ01000022_gene8647	7.625e-70	258.0	COG3391@1|root,COG3391@2|Bacteria,2IHBF@201174|Actinobacteria	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1873720_4	1313172.YM304_06770	4.594e-142	470.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HFD2_k127_1873720_0	1313172.YM304_15410	6.297e-202	640.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_1873720_9	1380393.JHVP01000024_gene3320	2.043e-110	367.0	COG2267@1|root,COG2267@2|Bacteria,2I1RU@201174|Actinobacteria,4EV6M@85013|Frankiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_1873720_21	258533.BN977_04337	2.861e-59	210.0	COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria,238T2@1762|Mycobacteriaceae	201174|Actinobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_1873720_28	1121957.ATVL01000009_gene900	9.139e-43	166.0	COG1028@1|root,COG1028@2|Bacteria,4NIH6@976|Bacteroidetes,47MQG@768503|Cytophagia	976|Bacteroidetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HFD2_k127_1873720_12	1223521.BBJX01000007_gene1464	1.299e-96	332.0	COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,4ACU3@80864|Comamonadaceae	28216|Betaproteobacteria	T	Pfam:Pyridox_oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
HFD2_k127_1873720_37	404589.Anae109_2917	2.485e-07	59.0	COG3576@1|root,COG3576@2|Bacteria,1PT74@1224|Proteobacteria,432EH@68525|delta/epsilon subdivisions,2WXW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1873720_32	215803.DB30_3346	3.627e-24	111.0	28ME7@1|root,2ZARX@2|Bacteria,1PMRG@1224|Proteobacteria,43E44@68525|delta/epsilon subdivisions,2WZNF@28221|Deltaproteobacteria,2Z2F5@29|Myxococcales	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_1873720_10	981369.JQMJ01000004_gene449	2.728e-105	364.0	COG0842@1|root,COG0842@2|Bacteria,2HNB6@201174|Actinobacteria,2NHZ8@228398|Streptacidiphilus	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HFD2_k127_1873720_11	1125971.ASJB01000099_gene2287	1.313e-103	349.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,4E1XJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
HFD2_k127_1873720_6	1125971.ASJB01000099_gene2288	1.08e-128	436.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4E1YQ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_1873720_3	408672.NBCG_00750	3.117e-153	508.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4DQ4R@85009|Propionibacteriales	201174|Actinobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
HFD2_k127_1874902_8	1313172.YM304_20520	2.924e-13	69.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CMSY@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_1874902_1	1313172.YM304_20510	8.784e-170	542.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CMYE@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD2_k127_1874902_6	1313172.YM304_20500	8.583e-27	115.0	COG1758@1|root,COG1758@2|Bacteria,2HG9P@201174|Actinobacteria,4CN82@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD2_k127_1874902_4	1313172.YM304_20490	1.794e-74	257.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CN5V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Guanylate kinase homologues.	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HFD2_k127_1874902_5	1313172.YM304_20480	5.814e-37	142.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CN68@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1874902_3	1313172.YM304_20470	3.05e-113	373.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CN0R@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD2_k127_1874902_0	1313172.YM304_20460	0.0	1671.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CMUA@84992|Acidimicrobiia	84992|Acidimicrobiia	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD2_k127_1874902_2	1313172.YM304_20450	2.902e-152	490.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4CMXV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD2_k127_1874902_7	1043493.BBLU01000001_gene883	9.297e-22	109.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria	201174|Actinobacteria	H	PFAM Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD2_k127_1932803_1	263358.VAB18032_22810	1.631e-47	179.0	COG1215@1|root,COG1215@2|Bacteria,2I3M7@201174|Actinobacteria,4DASK@85008|Micromonosporales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1932803_2	1448389.BAVQ01000036_gene874	3.518e-46	178.0	COG0463@1|root,COG0463@2|Bacteria,2GMPV@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_1932803_3	1232410.KI421428_gene1178	1.799e-37	152.0	COG0596@1|root,COG0596@2|Bacteria,1RGAP@1224|Proteobacteria,42XWU@68525|delta/epsilon subdivisions,2WSMY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_1932803_0	1313172.YM304_05280	1.031e-88	317.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,PKD,SprB
HFD2_k127_1942386_10	525909.Afer_1603	1.61e-17	81.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CMYB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_1942386_2	1313172.YM304_14240	1.623e-127	421.0	COG0392@1|root,COG0392@2|Bacteria,2HG5A@201174|Actinobacteria,4CN1V@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
HFD2_k127_1942386_9	1133849.O3I_020475	2.176e-42	166.0	COG1708@1|root,COG1708@2|Bacteria,2II5V@201174|Actinobacteria	201174|Actinobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4111,NTP_transf_2
HFD2_k127_1942386_6	1313172.YM304_14150	1.5e-55	204.0	COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Lysine_decarbox,NUDIX
HFD2_k127_1942386_0	1313172.YM304_14140	5.945e-248	778.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CMR3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1942386_5	1122939.ATUD01000001_gene551	5.978e-60	233.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria,4CR3I@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_1942386_8	1380347.JNII01000005_gene3148	4.208e-51	196.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4ESNK@85013|Frankiales	201174|Actinobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_1942386_7	2074.JNYD01000032_gene6498	1.992e-52	198.0	COG2227@1|root,COG2227@2|Bacteria,2I2JZ@201174|Actinobacteria,4EF8U@85010|Pseudonocardiales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_1942386_4	1313172.YM304_14110	1.354e-84	291.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HFD2_k127_1942386_1	1313172.YM304_14270	3.501e-175	567.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	84992|Acidimicrobiia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HFD2_k127_1942386_3	1313172.YM304_14280	6.982e-90	308.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	mcl2	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI,PEP-utilizers_C
HFD2_k127_1961793_11	365528.KB891103_gene3963	1.942e-30	140.0	COG0577@1|root,COG0577@2|Bacteria,2GWZR@201174|Actinobacteria,4EVD8@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HFD2_k127_1961793_0	216594.MMAR_4110	0.0	1168.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria,235F6@1762|Mycobacteriaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
HFD2_k127_1961793_6	525909.Afer_1526	1.396e-150	490.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CNIG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1961793_9	1313172.YM304_13050	1.938e-61	216.0	2F7CY@1|root,33ZTZ@2|Bacteria,2H76P@201174|Actinobacteria,4CNCM@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1961793_2	1313172.YM304_13020	9.253e-269	835.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4CMUV@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD2_k127_1961793_5	1150599.MPHLEI_26377	1.954e-159	512.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,234A3@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_1961793_12	561175.KB894097_gene219	8e-23	107.0	COG3467@1|root,COG3467@2|Bacteria,2I5VH@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_1961793_4	1313172.YM304_13000	3.288e-161	514.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_1961793_3	1313172.YM304_12990	1.078e-167	531.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4CMRK@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Isocitrate/isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_1961793_10	1313172.YM304_12970	5.535e-53	190.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CN6V@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD2_k127_1961793_7	1313172.YM304_12960	3.279e-107	354.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_1961793_8	1123023.JIAI01000001_gene6462	2.7e-79	294.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4DXYF@85010|Pseudonocardiales	201174|Actinobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HFD2_k127_1961793_1	1313172.YM304_01730	0.0	1034.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4CNNB@84992|Acidimicrobiia	84992|Acidimicrobiia	CE	Proline dehydrogenase	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
HFD2_k127_1975471_5	469371.Tbis_2135	4.995e-49	178.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4E5Z7@85010|Pseudonocardiales	201174|Actinobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HFD2_k127_1975471_0	1313172.YM304_14880	2.036e-192	612.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria	201174|Actinobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HFD2_k127_1975471_4	1313172.YM304_14860	3.742e-54	196.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_1975471_3	1313172.YM304_14850	3.499e-88	303.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
HFD2_k127_1975471_2	1313172.YM304_14840	2.522e-89	305.0	COG2378@1|root,COG2378@2|Bacteria,2HGFE@201174|Actinobacteria,4CND2@84992|Acidimicrobiia	84992|Acidimicrobiia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
HFD2_k127_1975471_1	1229780.BN381_640027	2.617e-130	428.0	COG1092@1|root,COG1092@2|Bacteria,2GXDD@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HFD2_k127_1975471_6	1137271.AZUM01000003_gene3638	3.779e-10	60.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4DZWQ@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Integrase, catalytic core	-	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_38,rve
HFD2_k127_1987314_2	1313172.YM304_24620	9.96e-120	395.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_1987314_0	1313172.YM304_24630	2.229e-209	681.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_1987314_5	1313172.YM304_24660	1.577e-42	165.0	COG4061@1|root,COG4061@2|Bacteria	2|Bacteria	H	5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
HFD2_k127_1987314_4	1313172.YM304_24670	8.383e-84	285.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	gpm	-	3.1.3.73,5.4.2.12	ko:K02226,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD2_k127_1987314_3	1313172.YM304_26840	3.327e-88	297.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4CMYW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_1987314_1	469371.Tbis_3121	1.144e-180	572.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DX8J@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA2	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_2005620_0	1410620.SHLA_78c000160	6.775e-182	580.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria,4BDUK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_2005620_1	1380390.JIAT01000017_gene5379	9.652e-157	512.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,4CPZ5@84995|Rubrobacteria	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_2005620_2	40571.JOEA01000011_gene2276	4.146e-120	406.0	COG3718@1|root,COG3718@2|Bacteria,2GM8S@201174|Actinobacteria,4DY8G@85010|Pseudonocardiales	201174|Actinobacteria	G	KduI/IolB family	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HFD2_k127_2005620_5	345341.KUTG_05444	6.679e-90	310.0	COG1830@1|root,COG1830@2|Bacteria,2GKTN@201174|Actinobacteria,4DYYW@85010|Pseudonocardiales	201174|Actinobacteria	G	deoxyribose-phosphate aldolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2005620_3	211114.JOEF01000002_gene3984	9.488e-108	357.0	COG0524@1|root,COG0524@2|Bacteria,2GM3N@201174|Actinobacteria,4E0W5@85010|Pseudonocardiales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	iolC	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_2005620_4	469371.Tbis_1713	5.457e-104	357.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4E0W1@85010|Pseudonocardiales	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_2005620_6	1380390.JIAT01000017_gene5377	2.944e-50	202.0	COG1172@1|root,COG1172@2|Bacteria,2GM9E@201174|Actinobacteria,4CPYC@84995|Rubrobacteria	84995|Rubrobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_2029974_5	1122609.AUGT01000011_gene3561	1.344e-94	312.0	COG5424@1|root,COG5424@2|Bacteria,2I97U@201174|Actinobacteria	201174|Actinobacteria	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HFD2_k127_2029974_13	1120973.AQXL01000130_gene1251	1.621e-25	109.0	COG0633@1|root,COG0633@2|Bacteria,1VP8M@1239|Firmicutes,4HRR5@91061|Bacilli	91061|Bacilli	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2
HFD2_k127_2029974_12	1194972.MVAC_07874	5.984e-26	120.0	COG2146@1|root,COG2146@2|Bacteria,2IIR1@201174|Actinobacteria,23A7B@1762|Mycobacteriaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD2_k127_2029974_11	331869.BAL199_16413	3.999e-36	150.0	COG4319@1|root,COG4319@2|Bacteria,1R7CB@1224|Proteobacteria,2U49V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD2_k127_2029974_10	196162.Noca_3748	4.203e-41	163.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_2029974_1	1313172.YM304_06630	8.936e-142	458.0	COG2421@1|root,COG2421@2|Bacteria,2HQSF@201174|Actinobacteria,4CNB9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HFD2_k127_2029974_9	298654.FraEuI1c_3649	1.429e-55	197.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4ESRX@85013|Frankiales	201174|Actinobacteria	O	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_2029974_0	981384.AEYW01000013_gene599	1.041e-230	723.0	COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2UQQQ@28211|Alphaproteobacteria,4N9X6@97050|Ruegeria	28211|Alphaproteobacteria	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD2_k127_2029974_4	263358.VAB18032_19850	6.203e-97	353.0	COG0226@1|root,COG0226@2|Bacteria,2GJXD@201174|Actinobacteria,4DA42@85008|Micromonosporales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HFD2_k127_2029974_6	263358.VAB18032_19855	1.549e-92	321.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4DBWE@85008|Micromonosporales	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_2029974_8	446470.Snas_2215	5.257e-78	284.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4EXVJ@85014|Glycomycetales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_2029974_3	1313172.YM304_07720	5.175e-116	395.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_2029974_2	68199.JNZO01000033_gene3023	7.129e-121	404.0	COG0457@1|root,COG0457@2|Bacteria	68199.JNZO01000033_gene3023|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2029974_7	404589.Anae109_4239	5.126e-81	282.0	COG0654@1|root,COG0654@2|Bacteria,1R03K@1224|Proteobacteria,43CQQ@68525|delta/epsilon subdivisions,2X7Y6@28221|Deltaproteobacteria,2Z1K0@29|Myxococcales	28221|Deltaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_2035980_3	1313172.YM304_35030	1.385e-138	450.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CNIH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_2035980_5	1040989.AWZU01000003_gene6681	1.033e-84	291.0	COG1335@1|root,COG3386@1|root,COG1335@2|Bacteria,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,3JUN4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GQ	SMP-30/Gluconolaconase/LRE-like region	MA20_13995	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Isochorismatase,SGL
HFD2_k127_2035980_8	1144305.PMI02_03505	0.0004573	52.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	Abi_2,HTH_18,SnoaL_2,SnoaL_4
HFD2_k127_2035980_7	710111.FraQA3DRAFT_2445	6.09e-21	106.0	COG4319@1|root,COG4319@2|Bacteria,2IICT@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_2035980_0	196162.Noca_0414	1.173e-238	760.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4DRUB@85009|Propionibacteriales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD2_k127_2035980_4	1313172.YM304_30850	3.917e-132	434.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_2035980_1	1229780.BN381_290117	8.185e-227	709.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,3UWSH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD2_k127_2035980_2	1313172.YM304_18910	1.323e-139	475.0	COG0297@1|root,COG0297@2|Bacteria,2GWGE@201174|Actinobacteria	201174|Actinobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD2_k127_2035980_6	35754.JNYJ01000034_gene2187	2.117e-31	136.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4DC9X@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_2036008_10	1313172.YM304_03450	1.04e-93	326.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	MA20_05265	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_2036008_21	67352.JODS01000006_gene6438	5.578e-28	131.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
HFD2_k127_2036008_12	1313172.YM304_29870	2.046e-80	281.0	COG0177@1|root,COG0177@2|Bacteria,2GNE5@201174|Actinobacteria,4CN48@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
HFD2_k127_2036008_14	1313172.YM304_29950	1.235e-64	231.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	wbbL_2	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HFD2_k127_2036008_20	179408.Osc7112_4230	1.537e-37	162.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CAP,HemolysinCabind,LGFP,VanY
HFD2_k127_2036008_17	1313172.YM304_36710	6.345e-58	226.0	COG4719@1|root,COG4719@2|Bacteria,2I7N6@201174|Actinobacteria	201174|Actinobacteria	S	Fungalysin metallopeptidase (M36)	-	-	-	ko:K01417	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF11,FTP,Peptidase_M36
HFD2_k127_2036008_0	1313172.YM304_29840	0.0	1450.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4CMQ1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_2036008_15	710421.Mycch_2074	3.567e-63	225.0	arCOG11509@1|root,31KIR@2|Bacteria,2IGM0@201174|Actinobacteria,23A9A@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2036008_4	1313172.YM304_29820	1.225e-137	459.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	yhcR	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	ChitinaseA_N,Glyco_hydro_18,Glyco_hydro_53,Reprolysin_4,fn3
HFD2_k127_2036008_7	1313172.YM304_29810	3.639e-109	376.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	yhcR	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	ChitinaseA_N,Glyco_hydro_18,Glyco_hydro_53,Reprolysin_4,fn3
HFD2_k127_2036008_18	1313172.YM304_29770	6.089e-56	205.0	COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4CN63@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HFD2_k127_2036008_5	1313172.YM304_29750	3.271e-131	427.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4CMZC@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_2036008_6	1229780.BN381_130129	4.66e-117	401.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,3UWI7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_2036008_3	1352941.M877_19560	1.194e-147	509.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
HFD2_k127_2036008_2	390989.JOEG01000001_gene5077	6.176e-168	553.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4DB3M@85008|Micromonosporales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_2036008_16	1464048.JNZS01000020_gene2185	2.088e-59	210.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DE55@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
HFD2_k127_2036008_9	104623.Ser39006_00226	9.824e-101	340.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,1RNF2@1236|Gammaproteobacteria,401D8@613|Serratia	1236|Gammaproteobacteria	S	Myo-inositol 2-dehydrogenase	-	-	1.1.1.361	ko:K18652	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_2036008_13	1238450.VIBNISOn1_1280077	1.414e-73	261.0	COG1082@1|root,COG1082@2|Bacteria,1R5PQ@1224|Proteobacteria,1RPVT@1236|Gammaproteobacteria,1XUV3@135623|Vibrionales	135623|Vibrionales	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_2036008_1	1410620.SHLA_78c000160	2.781e-212	679.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria,4BDUK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_2036008_8	1120948.KB903243_gene2411	7.153e-105	355.0	COG0654@1|root,COG0654@2|Bacteria,2GM48@201174|Actinobacteria,4DY2I@85010|Pseudonocardiales	201174|Actinobacteria	CH	4-hydroxybenzoate 3-monooxygenase	-	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD2_k127_2036008_11	591167.Sfla_5254	8.085e-88	316.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_2036008_19	1120960.ATXG01000019_gene3404	1.232e-42	168.0	COG0667@1|root,COG0667@2|Bacteria,2ID5A@201174|Actinobacteria	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_2036008_22	1229780.BN381_80084	6.924e-21	93.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,3UWBI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD2_k127_207754_15	443218.AS9A_1450	9.82e-14	72.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_207754_2	1343740.M271_00745	7.05e-144	473.0	COG0665@1|root,COG0665@2|Bacteria,2GPX6@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_207754_10	58344.JOEL01000022_gene1000	1.64e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,2IKK2@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein, arsR	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HFD2_k127_207754_1	1380390.JIAT01000010_gene3912	9.935e-171	556.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4CPPW@84995|Rubrobacteria	84995|Rubrobacteria	P	sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
HFD2_k127_207754_16	44060.JODL01000010_gene1575	1.863e-06	58.0	COG3023@1|root,COG3409@1|root,COG3023@2|Bacteria,COG3409@2|Bacteria,2GJ9M@201174|Actinobacteria	201174|Actinobacteria	V	Negative regulator of	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,PG_binding_1,SLT
HFD2_k127_207754_8	867903.ThesuDRAFT_02043	4.305e-59	218.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WD52@538999|Clostridiales incertae sedis	186801|Clostridia	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD2_k127_207754_9	1380390.JIAT01000009_gene904	1.195e-41	177.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,4CSEW@84995|Rubrobacteria	84995|Rubrobacteria	T	Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
HFD2_k127_207754_5	227882.SAV_2716	6.389e-96	323.0	COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,2IKNA@201174|Actinobacteria	201174|Actinobacteria	E	belongs to the urease gamma subunit family	ureAB	-	3.5.1.5	ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
HFD2_k127_207754_0	680198.SCAB_26901	6.885e-280	882.0	COG0804@1|root,COG0804@2|Bacteria,2GM7X@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HFD2_k127_207754_3	1463936.JOJI01000018_gene7732	5.96e-138	451.0	COG2957@1|root,COG2957@2|Bacteria,2GM6J@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD2_k127_207754_11	1158050.KB895469_gene3181	2.926e-29	121.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,1WBQU@1268|Micrococcaceae	201174|Actinobacteria	T	Universal stress protein	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_207754_14	211114.JOEF01000019_gene643	3.577e-14	83.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria,4EBND@85010|Pseudonocardiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HFD2_k127_207754_7	479434.Sthe_1081	2.63e-77	278.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_207754_12	479432.Sros_1134	2.112e-28	132.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria,4EFWG@85012|Streptosporangiales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD2_k127_207754_6	644283.Micau_5377	9.556e-85	292.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4DAYJ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_207754_13	1089545.KB913037_gene6146	2.708e-28	120.0	COG0454@1|root,COG0456@2|Bacteria,2IQC7@201174|Actinobacteria,4E3GV@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_207754_4	710111.FraQA3DRAFT_3338	8.902e-130	421.0	COG0604@1|root,COG0604@2|Bacteria,2GRJM@201174|Actinobacteria,4ETQB@85013|Frankiales	201174|Actinobacteria	C	Zn-dependent oxidoreductase, NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_2105227_6	1146883.BLASA_1543	9.346e-12	76.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HFD2_k127_2105227_2	1313172.YM304_19230	3.459e-169	539.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_2105227_0	1313172.YM304_19210	1.108e-231	725.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4CMTY@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD2_k127_2105227_5	1313172.YM304_17740	4.707e-44	172.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,Lipase_GDSL_2,PT-HINT,RHS_repeat,Ricin_B_lectin
HFD2_k127_2105227_1	1313172.YM304_19190	7.311e-221	689.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CNS0@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_2105227_4	1313172.YM304_19180	1.119e-69	257.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4CN6U@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HFD2_k127_2105227_3	1380390.JIAT01000017_gene5380	3.184e-79	267.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4CPNT@84995|Rubrobacteria	84995|Rubrobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_2141659_5	1313172.YM304_10590	3.872e-05	46.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4CN12@84992|Acidimicrobiia	84992|Acidimicrobiia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD2_k127_2141659_3	1313172.YM304_10580	4.581e-51	186.0	2DX1J@1|root,342ZM@2|Bacteria,2HGW0@201174|Actinobacteria,4CNX5@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2141659_6	391165.GbCGDNIH1_1866	0.0001799	49.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,2JTVG@204441|Rhodospirillales	204441|Rhodospirillales	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HFD2_k127_2141659_1	1313172.YM304_10560	1.416e-143	465.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4CMRB@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase family 4	wecA	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HFD2_k127_2141659_0	1229780.BN381_10027	1.339e-183	582.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,3UWBD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_2141659_2	1229780.BN381_80386	1.657e-66	230.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,3UWPM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD2_k127_2141659_4	1313172.YM304_10530	1.052e-22	101.0	COG0183@1|root,COG0183@2|Bacteria,2I3PP@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
HFD2_k127_219946_1	1313172.YM304_07520	7.164e-124	402.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4CMSG@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mg-chelatase subunit ChlI	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_219946_0	1313172.YM304_07510	5.412e-243	773.0	COG3250@1|root,COG3250@2|Bacteria,2GM69@201174|Actinobacteria	201174|Actinobacteria	G	beta-mannosidase	csxA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575	3.2.1.165,3.2.1.25	ko:K01192,ko:K15855	ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD2_k127_219946_2	1394178.AWOO02000044_gene4472	3.547e-35	137.0	2EPGV@1|root,33H3F@2|Bacteria,2H0AY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_221247_4	1151122.AQYD01000006_gene2430	4.011e-45	173.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4FM3W@85023|Microbacteriaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_221247_8	1123057.P872_07920	1.053e-06	54.0	COG3360@1|root,COG3360@2|Bacteria,4NURJ@976|Bacteroidetes,47SWS@768503|Cytophagia	976|Bacteroidetes	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HFD2_k127_221247_5	656024.FsymDg_2188	2.898e-34	138.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4ETFS@85013|Frankiales	201174|Actinobacteria	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD2_k127_221247_6	471852.Tcur_1210	9.52e-22	102.0	COG2032@1|root,COG2032@2|Bacteria,2INF6@201174|Actinobacteria,4EK07@85012|Streptosporangiales	201174|Actinobacteria	P	Copper/zinc superoxide dismutase (SODC)	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HFD2_k127_221247_2	448385.sce2876	4.21e-84	292.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,438I3@68525|delta/epsilon subdivisions,2X3T0@28221|Deltaproteobacteria,2YX1B@29|Myxococcales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HFD2_k127_221247_7	1463917.JODC01000003_gene5272	2.711e-13	81.0	2DMRR@1|root,32T8I@2|Bacteria,2IKQU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_221247_0	1394178.AWOO02000012_gene3773	9.273e-156	508.0	COG2909@1|root,COG2909@2|Bacteria,2I3S2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_221247_3	215803.DB30_4178	7.56e-52	203.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales	28221|Deltaproteobacteria	O	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6,Peptidase_S8
HFD2_k127_221247_1	391037.Sare_0434	3.003e-97	343.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DBPZ@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HFD2_k127_2253911_3	67352.JODS01000040_gene5552	3.562e-32	141.0	COG0477@1|root,COG2814@2|Bacteria,2GMKX@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD2_k127_2253911_1	1179773.BN6_41760	7.178e-101	342.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DZPY@85010|Pseudonocardiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
HFD2_k127_2253911_0	1313172.YM304_11430	6.549e-311	959.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_2253911_2	1313172.YM304_11440	1.17e-74	261.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CN3W@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HFD2_k127_2265896_3	1313172.YM304_42250	1.098e-36	141.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CNGA@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	Protein synonym hydantoin utilization protein A	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD2_k127_2265896_0	1313172.YM304_42240	1.87e-275	854.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CNVH@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	Protein synonym hydantoin utilization protein B	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD2_k127_2265896_1	1313172.YM304_42230	3.017e-208	682.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2265896_2	1313172.YM304_42220	2.008e-172	552.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_2278687_2	35754.JNYJ01000037_gene4689	1.307e-134	441.0	COG1609@1|root,COG1609@2|Bacteria,2IB6R@201174|Actinobacteria,4DII0@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	lacI	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
HFD2_k127_2278687_10	1172188.KB911820_gene2115	1.898e-77	269.0	COG2334@1|root,COG2334@2|Bacteria,2GQU8@201174|Actinobacteria,4FG7U@85021|Intrasporangiaceae	201174|Actinobacteria	S	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_2278687_32	1313172.YM304_37590	3.183e-18	87.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	ANTAR,MEDS,PAS_3,STAS,STAS_2
HFD2_k127_2278687_8	1313172.YM304_37600	2.55e-83	285.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_2278687_24	1313172.YM304_01020	7.898e-48	187.0	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HFD2_k127_2278687_37	58123.JOFJ01000017_gene4215	0.0001282	51.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4EFKH@85012|Streptosporangiales	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,PAS_4,SpoIIE
HFD2_k127_2278687_29	1122622.ATWJ01000013_gene179	1.472e-33	140.0	COG2197@1|root,COG2197@2|Bacteria,2IJB1@201174|Actinobacteria,4FGXB@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_2278687_36	471852.Tcur_3690	5.596e-07	56.0	COG2172@1|root,COG2172@2|Bacteria,2IFG9@201174|Actinobacteria,4EJ0V@85012|Streptosporangiales	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbW	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HFD2_k127_2278687_34	1303518.CCALI_01835	2.353e-09	65.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp-1	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_2278687_22	526225.Gobs_0116	1.08e-52	215.0	COG0642@1|root,COG0745@1|root,COG1366@1|root,COG2172@1|root,COG2203@1|root,COG2208@1|root,COG0745@2|Bacteria,COG1366@2|Bacteria,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4ERBM@85013|Frankiales	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA,PAS_3,PAS_4,Response_reg,STAS_2,SpoIIE
HFD2_k127_2278687_3	479434.Sthe_0078	1.134e-125	421.0	COG0477@1|root,COG0477@2|Bacteria,2G89T@200795|Chloroflexi,27Y75@189775|Thermomicrobia	189775|Thermomicrobia	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_2278687_28	590998.Celf_2054	5.407e-34	138.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HFD2_k127_2278687_33	745411.B3C1_06874	2.366e-15	86.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S2ZF@1236|Gammaproteobacteria,1J5SN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_2278687_4	797302.Halru_1252	1.734e-111	369.0	COG2141@1|root,arCOG02410@2157|Archaea,2XUEF@28890|Euryarchaeota,23RWN@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_2278687_30	1230341.MJ3_12145	1.468e-31	137.0	COG1414@1|root,COG1414@2|Bacteria,1UY5X@1239|Firmicutes,4HCG9@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator	kdgR1	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_2278687_31	479435.Kfla_4218	3.535e-26	113.0	COG1546@1|root,COG1546@2|Bacteria,2IQF0@201174|Actinobacteria,4DWPB@85009|Propionibacteriales	201174|Actinobacteria	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HFD2_k127_2278687_21	1403819.BATR01000069_gene2043	6.692e-53	198.0	COG0454@1|root,COG0456@2|Bacteria,46T4U@74201|Verrucomicrobia	74201|Verrucomicrobia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2278687_25	106370.Francci3_4046	1.797e-43	170.0	COG3145@1|root,COG3145@2|Bacteria	2|Bacteria	L	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
HFD2_k127_2278687_9	649638.Trad_2916	2.051e-80	285.0	COG1409@1|root,COG1409@2|Bacteria,1WMC6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM F5 8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2278687_20	1385935.N836_35605	2.122e-53	201.0	COG0438@1|root,COG1215@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,1G3C9@1117|Cyanobacteria,1HBI4@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2278687_12	1313172.YM304_30900	2.716e-70	272.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
HFD2_k127_2278687_35	1283299.AUKG01000002_gene4914	4.586e-09	71.0	COG3291@1|root,COG4870@1|root,COG3291@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CBM_6,DUF11,PKD,Peptidase_C1
HFD2_k127_2278687_19	561175.KB894093_gene2991	3.091e-55	204.0	COG1134@1|root,COG1134@2|Bacteria,2I2SZ@201174|Actinobacteria,4ER4W@85012|Streptosporangiales	201174|Actinobacteria	GM	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HFD2_k127_2278687_13	1229780.BN381_410041	1.445e-69	244.0	COG0730@1|root,COG0730@2|Bacteria,2GNW8@201174|Actinobacteria	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_2278687_16	1223523.H340_23478	1.176e-64	247.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria	201174|Actinobacteria	G	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2278687_15	649638.Trad_2916	1.531e-66	255.0	COG1409@1|root,COG1409@2|Bacteria,1WMC6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM F5 8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2278687_14	1123073.KB899241_gene3463	2.615e-67	257.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_C,Formyl_trans_N,GHL10,Polysacc_deac_1
HFD2_k127_2278687_5	1380390.JIAT01000010_gene4362	2.926e-111	374.0	COG0438@1|root,COG0438@2|Bacteria,2GM53@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_2278687_6	485913.Krac_2413	6.852e-92	314.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_2278687_27	106370.Francci3_0736	2.31e-37	158.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4ERBZ@85013|Frankiales	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	wbbL	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	iNJ661.Rv3265c	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_2278687_18	218284.CCDN010000001_gene1842	8.929e-59	217.0	2CUQ5@1|root,32SVT@2|Bacteria,1VW80@1239|Firmicutes,4HW7I@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2278687_17	1089544.KB912942_gene1845	6.58e-63	229.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4E0GC@85010|Pseudonocardiales	201174|Actinobacteria	P	Catalyzes the synthesis of activated sulfate	cysN	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
HFD2_k127_2278687_1	685727.REQ_17320	1.195e-134	451.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4FUKW@85025|Nocardiaceae	201174|Actinobacteria	EH	sulfate adenylyltransferase	cysD	GO:0000103,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:1902494,GO:1902503,GO:1990234	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD2_k127_2278687_0	1120936.KB907208_gene783	1.105e-179	581.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4EFW9@85012|Streptosporangiales	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
HFD2_k127_2278687_11	326424.FRAAL6118	4.611e-75	270.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4ERXB@85013|Frankiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_2278687_7	298655.KI912266_gene1929	2.335e-85	294.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,4EUBX@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HFD2_k127_2278687_26	2074.JNYD01000003_gene4108	1.019e-41	171.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria	201174|Actinobacteria	G	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HFD2_k127_2278687_23	1123073.KB899245_gene23	5.179e-48	177.0	COG3291@1|root,COG4102@1|root,COG3291@2|Bacteria,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Cleaved_Adhesin,Reprolysin_4
HFD2_k127_2281061_13	1429046.RR21198_4080	4.785e-29	121.0	COG1018@1|root,COG4097@1|root,COG1018@2|Bacteria,COG4097@2|Bacteria,2GJCV@201174|Actinobacteria,4FU7D@85025|Nocardiaceae	201174|Actinobacteria	C	Protein involved in monooxygenase activity, electron transporter activity, iron ion binding, electron transport, transport and aromatic compound catabolism	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_2281061_5	469383.Cwoe_4507	3.157e-99	340.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4CQ9D@84995|Rubrobacteria	84995|Rubrobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_2281061_11	1313172.YM304_39170	3.554e-37	153.0	COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CN4Z@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HFD2_k127_2281061_2	525909.Afer_1962	1.421e-121	400.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4CMRG@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_2281061_10	1313172.YM304_39190	4.075e-44	168.0	COG0576@1|root,COG0576@2|Bacteria,2HGAI@201174|Actinobacteria,4CN9N@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD2_k127_2281061_0	1313172.YM304_39200	0.0	1033.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD2_k127_2281061_9	345341.KUTG_09857	8.686e-49	186.0	2CCFM@1|root,33T1W@2|Bacteria,2IA4M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_2281061_3	1121927.GOHSU_17_00310	1.885e-116	400.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4GAMM@85026|Gordoniaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
HFD2_k127_2281061_8	1089544.KB912942_gene1812	4.82e-52	202.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria,4DYZM@85010|Pseudonocardiales	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD2_k127_2281061_7	591159.ACEZ01000137_gene2228	7.742e-77	267.0	COG0745@1|root,COG0745@2|Bacteria,2GKJK@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	tcsR4	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2281061_4	1001240.GY21_12265	1.388e-103	358.0	COG0642@1|root,COG0642@2|Bacteria,2I2VJ@201174|Actinobacteria,4FTR6@85023|Microbacteriaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_2281061_12	1242864.D187_006571	1.301e-36	148.0	COG3000@1|root,COG3000@2|Bacteria,1NBCT@1224|Proteobacteria	1224|Proteobacteria	I	B domain of TMEM189, localisation domain	carF	-	-	ko:K20656	-	-	-	-	ko00000,ko04131	-	-	-	TMEM189_B_dmain
HFD2_k127_2281061_1	1313172.YM304_34120	4.54e-253	807.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_2281061_6	1122611.KB903996_gene7448	6.947e-81	280.0	COG2222@1|root,COG2222@2|Bacteria,2IBP7@201174|Actinobacteria,4EIEZ@85012|Streptosporangiales	201174|Actinobacteria	M	sugar isomerase	-	-	-	-	-	-	-	-	-	-	-	-	SIS
HFD2_k127_2375805_1	1082933.MEA186_07117	2.258e-154	501.0	COG0006@1|root,COG0006@2|Bacteria,1N8DW@1224|Proteobacteria,2U2SF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_2375805_2	285535.JOEY01000060_gene8955	3.563e-138	453.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria	201174|Actinobacteria	F	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_2375805_3	1313172.YM304_30900	1.026e-68	261.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
HFD2_k127_2375805_6	526225.Gobs_3420	1.916e-44	173.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_2375805_4	685727.REQ_18420	5.387e-61	233.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
HFD2_k127_2375805_0	1380393.JHVP01000003_gene1142	1.209e-163	537.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4ERPD@85013|Frankiales	201174|Actinobacteria	U	PFAM Type II secretion system protein E	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD2_k127_2375805_5	1292020.H483_0115375	5.489e-50	192.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria	201174|Actinobacteria	D	Pilus assembly protein	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
HFD2_k127_2375805_7	290399.Arth_2923	7.117e-28	123.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_2375805_8	452863.Achl_2645	1.028e-11	74.0	COG4655@1|root,COG4655@2|Bacteria,2IGK1@201174|Actinobacteria	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD2_k127_2393907_5	1313172.YM304_19380	6.221e-35	139.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4CNC7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD2_k127_2393907_8	1303518.CCALI_00587	0.0003792	52.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase,Polyketide_cyc2
HFD2_k127_2393907_1	1313172.YM304_19780	2.66e-96	343.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4CN3N@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
HFD2_k127_2393907_4	935866.JAER01000024_gene3108	6.142e-39	156.0	COG0095@1|root,COG0095@2|Bacteria,2GTPJ@201174|Actinobacteria	201174|Actinobacteria	H	Lipoate-protein ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2393907_2	1313172.YM304_19370	1.62e-71	246.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4CN5M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD2_k127_2393907_0	1313172.YM304_19350	8.333e-215	671.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CNPK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_2393907_3	1229780.BN381_140020	1.128e-65	234.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,3UWRA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_2393907_7	1313172.YM304_19330	1.354e-07	54.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4CNN6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_241365_3	1123508.JH636447_gene7821	9.443e-17	93.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
HFD2_k127_241365_1	1298863.AUEP01000013_gene4083	1.182e-179	570.0	COG0683@1|root,COG0683@2|Bacteria,2I8ME@201174|Actinobacteria,4DR8B@85009|Propionibacteriales	201174|Actinobacteria	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_5,Peripla_BP_6
HFD2_k127_241365_2	1040986.ATYO01000006_gene358	1.442e-38	147.0	2C6FT@1|root,334HA@2|Bacteria,1NKG2@1224|Proteobacteria,2UNCP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_241365_0	1298863.AUEP01000013_gene4081	2.383e-288	910.0	COG2114@1|root,COG2771@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2771@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DP21@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,GerE,Guanylate_cyc,NB-ARC,Trans_reg_C
HFD2_k127_2567033_0	1313172.YM304_03760	2.064e-144	459.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_2567033_5	1133849.O3I_038175	4.455e-05	53.0	2E5RJ@1|root,330G5@2|Bacteria,2GQFX@201174|Actinobacteria,4G2H7@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4232
HFD2_k127_2567033_1	196162.Noca_4144	2.137e-57	206.0	COG0590@1|root,COG0590@2|Bacteria,2IFH2@201174|Actinobacteria,4DUU9@85009|Propionibacteriales	201174|Actinobacteria	FJ	MafB19-like deaminase	codA	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD2_k127_2567033_3	1120950.KB892765_gene5700	1.011e-12	74.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria,4DVX3@85009|Propionibacteriales	201174|Actinobacteria	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174,ko:K07038	-	-	-	-	ko00000,ko01000	-	-	-	SNase
HFD2_k127_2567033_2	247633.GP2143_02804	7.16e-14	81.0	COG2030@1|root,COG2030@2|Bacteria,1NYEM@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	MA20_27475	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2669300_1	1415775.U729_956	2.849e-221	710.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36EIR@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type	-	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
HFD2_k127_2669300_5	749414.SBI_04807	1.423e-104	348.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_2669300_7	66429.JOFL01000003_gene3228	1.793e-99	331.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_2669300_17	1463885.KL578506_gene6723	2.989e-41	167.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_2669300_20	1463885.KL578506_gene6722	1.183e-15	89.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_2669300_2	716928.AJQT01000058_gene5367	1.42e-197	638.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2TQK2@28211|Alphaproteobacteria,4B9N1@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HFD2_k127_2669300_3	1048339.KB913029_gene2528	9.129e-171	580.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_2669300_6	1313172.YM304_27930	1.921e-102	361.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_2669300_13	105420.BBPO01000015_gene5058	1.081e-55	219.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,2NHDN@228398|Streptacidiphilus	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_2669300_9	1464048.JNZS01000008_gene6215	2.848e-83	281.0	COG2197@1|root,COG2197@2|Bacteria,2GIXB@201174|Actinobacteria,4DCD0@85008|Micromonosporales	201174|Actinobacteria	K	a CheY-like receiver domain and	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_2669300_14	1038869.AXAN01000001_gene3718	6.631e-53	195.0	COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,2WG8W@28216|Betaproteobacteria,1KG2B@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_2669300_4	1283299.AUKG01000003_gene217	1.819e-125	435.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4CQYN@84995|Rubrobacteria	84995|Rubrobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_2669300_8	1470591.BW41_03334	5.664e-89	306.0	COG2267@1|root,COG2267@2|Bacteria,1QVG0@1224|Proteobacteria,2TS32@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_2669300_21	383372.Rcas_3329	1.298e-13	83.0	COG2866@1|root,COG2866@2|Bacteria,2GB4F@200795|Chloroflexi,3751R@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_2669300_19	1120949.KB903295_gene2158	7.474e-16	89.0	COG0542@1|root,COG2319@1|root,COG0542@2|Bacteria,COG2319@2|Bacteria,2GJ77@201174|Actinobacteria,4D8QE@85008|Micromonosporales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,Clp_N,Peptidase_C14,TIR_2
HFD2_k127_2669300_15	1123023.JIAI01000005_gene511	7.291e-48	179.0	COG1309@1|root,COG1309@2|Bacteria,2IKPS@201174|Actinobacteria,4EEZ8@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_2669300_16	1449049.JONW01000012_gene121	8.982e-42	164.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,2KIJ7@204458|Caulobacterales	204458|Caulobacterales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HFD2_k127_2669300_11	469383.Cwoe_0731	7.338e-62	233.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_2669300_10	1120949.KB903299_gene6036	8.051e-81	279.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4D9AT@85008|Micromonosporales	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_2669300_23	751944.HALDL1_01580	6.63e-05	50.0	COG0596@1|root,arCOG01648@2157|Archaea,2XVTE@28890|Euryarchaeota,23TCW@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_2669300_12	1448389.BAVQ01000003_gene3509	2.178e-58	211.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2IIHU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2669300_22	1094980.Mpsy_1736	3.851e-11	73.0	arCOG06838@1|root,arCOG06838@2157|Archaea,2Y4P8@28890|Euryarchaeota,2NB41@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2669300_0	1172188.KB911822_gene935	0.0	1504.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4FIX8@85021|Intrasporangiaceae	201174|Actinobacteria	M	Salmonella virulence plasmid 65kDa B protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB,TcdB_toxin_midN
HFD2_k127_2669300_18	345341.KUTG_08442	8.026e-19	102.0	COG2730@1|root,COG2730@2|Bacteria,2IJWB@201174|Actinobacteria	201174|Actinobacteria	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
HFD2_k127_2690123_3	1166018.FAES_2881	3.954e-69	245.0	COG2334@1|root,COG2334@2|Bacteria,4NITA@976|Bacteroidetes,47M89@768503|Cytophagia	976|Bacteroidetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2690123_4	1313172.YM304_25880	1.565e-64	225.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4CN21@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HFD2_k127_2690123_2	1313172.YM304_25900	1.069e-97	341.0	2F1PM@1|root,33UPX@2|Bacteria,2H4R3@201174|Actinobacteria,4CN41@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2690123_1	1313172.YM304_25910	5.858e-121	392.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4CNVN@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_2690123_6	1313172.YM304_25920	2.561e-24	113.0	COG0454@1|root,COG0456@2|Bacteria,2HBQK@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_2690123_5	1313172.YM304_25940	1.835e-25	111.0	2DDS5@1|root,2ZJ1Y@2|Bacteria,2HDMP@201174|Actinobacteria,4CP3T@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2690123_0	1313172.YM304_25950	2.324e-265	824.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
HFD2_k127_2727855_2	867845.KI911784_gene635	4.583e-143	466.0	COG0318@1|root,COG0318@2|Bacteria,2G83V@200795|Chloroflexi,376U1@32061|Chloroflexia	32061|Chloroflexia	IQ	AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2727855_3	383372.Rcas_0698	3.248e-107	376.0	COG1893@1|root,COG1893@2|Bacteria,2GAI6@200795|Chloroflexi,376A7@32061|Chloroflexia	32061|Chloroflexia	H	2-dehydropantoate 2-reductase	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD2_k127_2727855_1	882083.SacmaDRAFT_3058	1.565e-143	468.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4DXXQ@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
HFD2_k127_2727855_6	1121933.AUHH01000006_gene699	4.068e-54	196.0	COG2259@1|root,COG2259@2|Bacteria,2IJ0I@201174|Actinobacteria,4DRJ9@85009|Propionibacteriales	201174|Actinobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_2727855_9	1144312.PMI09_04622	1.467e-43	171.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TUB8@28211|Alphaproteobacteria,4BMU0@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_2727855_10	469383.Cwoe_1913	3.214e-27	128.0	COG0392@1|root,COG0392@2|Bacteria,2HQ3T@201174|Actinobacteria,4CRKA@84995|Rubrobacteria	84995|Rubrobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HFD2_k127_2727855_11	309801.trd_A0882	5.878e-27	123.0	COG0671@1|root,COG0671@2|Bacteria,2GB9M@200795|Chloroflexi,27YCA@189775|Thermomicrobia	189775|Thermomicrobia	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_2727855_12	1009370.ALO_05313	2.255e-09	68.0	COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,4H33V@909932|Negativicutes	909932|Negativicutes	M	Lipid A biosynthesis	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD2_k127_2727855_5	247633.GP2143_10007	6.051e-76	270.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	phyH	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_2727855_7	1121378.KB899702_gene2274	1.02e-53	196.0	COG1280@1|root,COG1280@2|Bacteria,1WMFT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HFD2_k127_2727855_4	1137269.AZWL01000019_gene4155	5.527e-76	260.0	COG1576@1|root,COG3832@1|root,COG1576@2|Bacteria,COG3832@2|Bacteria,2I3MI@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
HFD2_k127_2727855_8	1123023.JIAI01000016_gene3378	1.796e-44	166.0	COG2318@1|root,COG2318@2|Bacteria,2IM8X@201174|Actinobacteria,4E4EK@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_2727855_0	1297865.APJD01000006_gene4753	1.17e-161	513.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,3JRID@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	MA20_04980	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
HFD2_k127_2738962_14	1313172.YM304_19740	4.06e-60	213.0	2F9Q3@1|root,34209@2|Bacteria,2H616@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738962_13	1313172.YM304_19730	3.422e-67	232.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4CN4U@84992|Acidimicrobiia	84992|Acidimicrobiia	FG	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HFD2_k127_2738962_9	369723.Strop_3064	5.451e-93	315.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4D90V@85008|Micromonosporales	201174|Actinobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
HFD2_k127_2738962_2	471852.Tcur_2095	9.637e-229	725.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4EG5V@85012|Streptosporangiales	201174|Actinobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
HFD2_k127_2738962_11	1313172.YM304_19710	1.814e-78	269.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_2738962_3	1313172.YM304_19700	1.358e-199	629.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4CMRH@84992|Acidimicrobiia	84992|Acidimicrobiia	H	tRNA synthetases class I (C) catalytic domain	mshC	-	6.3.1.13	ko:K15526	-	-	-	-	ko00000,ko01000	-	-	-	tRNA-synt_1e
HFD2_k127_2738962_7	1313172.YM304_19690	8.511e-111	365.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4CN3R@84992|Acidimicrobiia	84992|Acidimicrobiia	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD2_k127_2738962_5	1313172.YM304_19680	2.187e-128	416.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4CMWN@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_2738962_4	694430.Natoc_2360	4.361e-135	449.0	COG1249@1|root,arCOG01068@2157|Archaea	2157|Archaea	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NAD_binding_8,Pyr_redox_2
HFD2_k127_2738962_1	1313172.YM304_19650	8.798e-271	850.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CMYD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
HFD2_k127_2738962_16	1313172.YM304_19640	1.327e-39	163.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4CN7W@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_2738962_10	1313172.YM304_19630	2.154e-87	295.0	2BWZ3@1|root,33X4C@2|Bacteria,2H5EF@201174|Actinobacteria,4CN6H@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738962_0	1313172.YM304_19620	0.0	1757.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase alpha chain like domain	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD2_k127_2738962_15	1313172.YM304_19610	4.446e-52	189.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4CN47@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF2587)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2587
HFD2_k127_2738962_6	1313172.YM304_19600	7.67e-126	414.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4CMXF@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD2_k127_2738962_12	1313172.YM304_19590	2.094e-68	237.0	COG1959@1|root,COG1959@2|Bacteria,2HG5V@201174|Actinobacteria,4CN2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD2_k127_2738962_8	1313172.YM304_19580	7.127e-105	347.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CN1X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HFD2_k127_2761339_2	1380347.JNII01000009_gene1993	4.971e-74	284.0	COG1752@1|root,COG1752@2|Bacteria,2IB41@201174|Actinobacteria,4EUJE@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3376)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3376,Patatin
HFD2_k127_2761339_4	204669.Acid345_0467	2.593e-31	134.0	COG0736@1|root,COG2091@1|root,COG0736@2|Bacteria,COG2091@2|Bacteria,3Y8HB@57723|Acidobacteria	57723|Acidobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD2_k127_2761339_1	234267.Acid_3078	8.57e-233	734.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_2761339_0	234267.Acid_3077	0.0	1785.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
HFD2_k127_2805076_1	1313172.YM304_04210	2.215e-60	217.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
HFD2_k127_2805076_0	743718.Isova_2412	6.695e-71	269.0	COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,2HF2H@201174|Actinobacteria,4F51U@85017|Promicromonosporaceae	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
HFD2_k127_2805076_2	208439.AJAP_00595	1.257e-37	162.0	2C19J@1|root,2ZRV4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2805076_4	290633.GOX1123	0.0004837	53.0	COG0438@1|root,COG0463@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	rgpF	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	DUF3880,Glyco_tranf_2_3,Glyco_trans_1_2,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,RgpF
HFD2_k127_2805076_3	1123073.KB899245_gene23	1.748e-31	142.0	COG3291@1|root,COG4102@1|root,COG3291@2|Bacteria,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Cleaved_Adhesin,Reprolysin_4
HFD2_k127_284757_36	298655.KI912266_gene5121	9.587e-07	55.0	COG2197@1|root,COG2203@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,2GPKD@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_284757_29	929712.KI912613_gene2126	6.382e-34	141.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_284757_6	384765.SIAM614_07543	1.428e-159	523.0	COG0112@1|root,COG0112@2|Bacteria,1MWDM@1224|Proteobacteria,2TS5T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine hydroxymethyltransferase	glyA_3	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_284757_8	1117379.BABA_14322	3.634e-149	486.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,1ZHB1@1386|Bacillus	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_284757_9	656024.FsymDg_0954	1.237e-129	425.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4EUMZ@85013|Frankiales	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HFD2_k127_284757_7	760117.JN27_19635	3.971e-151	483.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJHD@28216|Betaproteobacteria,472U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the arginase family	-	-	3.5.3.7	ko:K12255	ko00330,ko01100,map00330,map01100	-	R01990	RC00024,RC00329	ko00000,ko00001,ko01000	-	-	-	Arginase
HFD2_k127_284757_17	909943.HIMB100_00000060	2.036e-76	262.0	COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,2U0VM@28211|Alphaproteobacteria,4BQBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	HD phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD,MIOX
HFD2_k127_284757_32	1348663.KCH_77640	7.953e-22	108.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,2I1YM@201174|Actinobacteria,2M5RN@2063|Kitasatospora	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HFD2_k127_284757_4	1313172.YM304_04550	9.774e-206	655.0	COG2146@1|root,COG2146@2|Bacteria,2GQWS@201174|Actinobacteria	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	Rieske
HFD2_k127_284757_22	1313172.YM304_04540	8.774e-56	198.0	COG0789@1|root,COG0789@2|Bacteria,2GKTU@201174|Actinobacteria,4CNV2@84992|Acidimicrobiia	84992|Acidimicrobiia	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind
HFD2_k127_284757_10	1280950.HJO_11952	2.796e-118	394.0	COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_284757_5	1304865.JAGF01000001_gene3256	7.855e-169	539.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD2_k127_284757_26	1463909.KL585966_gene449	2.287e-38	154.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_284757_28	208444.JNYY01000003_gene1963	2.743e-37	151.0	COG2764@1|root,COG2764@2|Bacteria,2GS13@201174|Actinobacteria,4ECU4@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_284757_21	1122609.AUGT01000002_gene3889	1.981e-58	207.0	COG2230@1|root,COG2230@2|Bacteria,2IHZD@201174|Actinobacteria,4DR2D@85009|Propionibacteriales	201174|Actinobacteria	M	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_284757_20	351607.Acel_0184	6.019e-69	245.0	COG0604@1|root,COG0604@2|Bacteria,2I9BF@201174|Actinobacteria,4ETNW@85013|Frankiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD2_k127_284757_23	1469245.JFBG01000010_gene595	9.66e-50	191.0	COG2040@1|root,COG2040@2|Bacteria,1QU2A@1224|Proteobacteria,1RS8M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	homocysteine	mmuM	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD2_k127_284757_0	215803.DB30_7204	0.0	1320.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_284757_33	1380390.JIAT01000012_gene3230	5.178e-12	67.0	COG0277@1|root,COG0277@2|Bacteria,2GMAQ@201174|Actinobacteria,4CRC0@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HFD2_k127_284757_18	463191.SSEG_01982	1.572e-73	270.0	COG1028@1|root,COG1028@2|Bacteria,2GJYV@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_284757_14	1297865.APJD01000006_gene4766	4.505e-86	296.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VEY3@28211|Alphaproteobacteria,3JXZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_284757_35	1040989.AWZU01000022_gene4750	1.381e-07	63.0	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2TR27@28211|Alphaproteobacteria,3JRGT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	MA20_19820	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_284757_27	1172188.KB911820_gene2546	2.716e-38	154.0	COG0346@1|root,COG0346@2|Bacteria,2IPGW@201174|Actinobacteria,4FH0K@85021|Intrasporangiaceae	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HFD2_k127_284757_15	1223545.GS4_33_00480	2.041e-84	302.0	COG2008@1|root,COG2008@2|Bacteria,2GJ0V@201174|Actinobacteria,4GCDP@85026|Gordoniaceae	201174|Actinobacteria	E	Beta-eliminating lyase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD2_k127_284757_16	1347369.CCAD010000086_gene1738	8.769e-81	279.0	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli,1ZB27@1386|Bacillus	91061|Bacilli	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD2_k127_284757_19	3711.Bra030616.1-P	3.02e-72	257.0	COG1957@1|root,KOG2938@2759|Eukaryota,37HXM@33090|Viridiplantae,3GC13@35493|Streptophyta,3HQE2@3699|Brassicales	35493|Streptophyta	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.3	ko:K01240	ko00240,ko00760,map00240,map00760	-	R01080,R01273,R10046	RC00033,RC00063,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HFD2_k127_284757_13	357808.RoseRS_2516	2.369e-92	319.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi,377RE@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Methionine synthase, vitamin-B12 independent	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_284757_30	298654.FraEuI1c_2591	1.324e-25	109.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	bcpB	-	1.11.1.15	ko:K03386,ko:K03564	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA,HxlR,MerR_1,Redoxin
HFD2_k127_284757_34	1165841.SULAR_09709	1.198e-11	65.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_284757_11	196162.Noca_1837	2.334e-115	383.0	COG0665@1|root,COG0665@2|Bacteria,2HNJI@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_284757_3	298654.FraEuI1c_3065	6.348e-210	671.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD2_k127_284757_31	326424.FRAAL2515	5.71e-23	106.0	2DWZW@1|root,342QA@2|Bacteria,2GQ7R@201174|Actinobacteria,4EWJM@85013|Frankiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_284757_1	42256.RradSPS_3092	0.0	1031.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_284757_12	1229780.BN381_130289	5.207e-106	355.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,3UWI0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HFD2_k127_284757_25	106370.Francci3_1964	5.707e-47	178.0	COG4420@1|root,COG4420@2|Bacteria,2INCC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HFD2_k127_284757_24	298655.KI912266_gene2361	1.409e-49	179.0	COG0346@1|root,COG0346@2|Bacteria,2GQZ9@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_284757_2	1298863.AUEP01000011_gene627	1.827e-284	907.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2GM4U@201174|Actinobacteria,4DUTC@85009|Propionibacteriales	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
HFD2_k127_288282_1	1343740.M271_00745	5.871e-109	362.0	COG0665@1|root,COG0665@2|Bacteria,2GPX6@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_288282_3	443218.AS9A_1450	1.99e-23	109.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_288282_0	196162.Noca_0642	0.0	1114.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4DPE4@85009|Propionibacteriales	201174|Actinobacteria	E	glycine cleavage T protein (aminomethyl transferase)	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_288282_2	1122182.KB903836_gene4975	1.229e-102	361.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2GJYH@201174|Actinobacteria,4DGVV@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PKD,Peptidase_S8
HFD2_k127_2887740_2	1313172.YM304_27590	3.982e-105	353.0	COG0498@1|root,COG0498@2|Bacteria,2IH7W@201174|Actinobacteria	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HFD2_k127_2887740_0	1313172.YM304_27600	1.17e-259	807.0	COG0031@1|root,COG0031@2|Bacteria,2IEI6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2887740_3	1236541.BALL01000003_gene555	8.508e-45	183.0	COG2345@1|root,COG2345@2|Bacteria,1RDXT@1224|Proteobacteria,1S4DW@1236|Gammaproteobacteria,2Q8UB@267890|Shewanellaceae	1236|Gammaproteobacteria	K	PFAM Helix-turn-helix, type 11 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_24
HFD2_k127_2887740_1	1313172.YM304_27660	1.738e-219	690.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
HFD2_k127_293825_3	1229780.BN381_80336	2.769e-155	499.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,3UWDH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD2_k127_293825_12	1121877.JQKF01000002_gene1617	3.647e-18	94.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4CN8X@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
HFD2_k127_293825_5	1429046.RR21198_1177	9.058e-146	469.0	COG1752@1|root,COG1752@2|Bacteria,2HJ6N@201174|Actinobacteria,4G5HY@85025|Nocardiaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_293825_2	106370.Francci3_3987	8.939e-161	518.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4ES6H@85013|Frankiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HFD2_k127_293825_6	1380355.JNIJ01000053_gene2122	3.969e-118	387.0	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,2TVH8@28211|Alphaproteobacteria,3JS6S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	KR domain	MA20_36825	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_293825_4	1313172.YM304_26880	1.111e-147	482.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria	201174|Actinobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD2_k127_293825_7	1313172.YM304_26870	9.422e-100	329.0	COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria	201174|Actinobacteria	F	Thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HFD2_k127_293825_11	479434.Sthe_0357	1.418e-34	142.0	COG1376@1|root,COG3103@1|root,COG3420@1|root,COG1376@2|Bacteria,COG3103@2|Bacteria,COG3420@2|Bacteria,2GBHA@200795|Chloroflexi,27XMC@189775|Thermomicrobia	189775|Thermomicrobia	PT	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
HFD2_k127_293825_0	1313172.YM304_24460	0.0	2308.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4CMR1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD2_k127_293825_1	1313172.YM304_24470	5.443e-260	807.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4CMR7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HFD2_k127_293825_13	1313172.YM304_24480	4.053e-18	92.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M15_4
HFD2_k127_293825_8	1313172.YM304_34220	3.081e-68	240.0	COG0346@1|root,COG0346@2|Bacteria,2H7KR@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD2_k127_293825_10	278957.ABEA03000176_gene2782	3.43e-42	162.0	COG3132@1|root,COG3132@2|Bacteria,46VIH@74201|Verrucomicrobia,3K85I@414999|Opitutae	414999|Opitutae	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HFD2_k127_293825_9	35754.JNYJ01000054_gene9827	7.592e-54	201.0	COG2808@1|root,COG2808@2|Bacteria,2IEXV@201174|Actinobacteria,4DCNS@85008|Micromonosporales	201174|Actinobacteria	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
HFD2_k127_2975649_25	1382306.JNIM01000001_gene4085	1.281e-19	93.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD2_k127_2975649_6	1123072.AUDH01000008_gene290	2.652e-145	468.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TU4F@28211|Alphaproteobacteria,2JV7T@204441|Rhodospirillales	204441|Rhodospirillales	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
HFD2_k127_2975649_15	869210.Marky_1947	2.142e-48	182.0	COG0259@1|root,COG0259@2|Bacteria,1WJYQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HFD2_k127_2975649_11	2074.JNYD01000016_gene4205	1.926e-82	287.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,4EBZH@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_2975649_9	1229780.BN381_10108	4.104e-90	303.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,3UWT0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD2_k127_2975649_13	1313172.YM304_29090	2.211e-53	196.0	2BJWW@1|root,32E9A@2|Bacteria,2HGG7@201174|Actinobacteria,4CNDN@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2975649_24	929712.KI912613_gene1694	1.198e-21	100.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,Cytochrom_C
HFD2_k127_2975649_5	290397.Adeh_2406	2.562e-153	505.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HFD2_k127_2975649_7	234267.Acid_3505	1.033e-100	354.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_2975649_22	641491.DND132_0694	4.658e-23	104.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	pcmE	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD2_k127_2975649_28	765420.OSCT_2991	2.364e-11	71.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	qcrC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0098822,GO:1901363,GO:1901564	1.8.2.2	ko:K00406,ko:K03889,ko:K17222,ko:K19713	ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020	M00151,M00156,M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3
HFD2_k127_2975649_4	675635.Psed_2533	2.599e-158	507.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4E8PX@85010|Pseudonocardiales	201174|Actinobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD2_k127_2975649_2	477641.MODMU_5069	3.5e-199	647.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERST@85013|Frankiales	201174|Actinobacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_2975649_23	627192.SLG_36710	5.656e-22	102.0	COG4319@1|root,COG4319@2|Bacteria,1QUR3@1224|Proteobacteria,2TW48@28211|Alphaproteobacteria,2K85Y@204457|Sphingomonadales	204457|Sphingomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_2975649_12	469383.Cwoe_1934	1.601e-74	260.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_2975649_3	1313172.YM304_29120	2.764e-179	575.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4CMUJ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD2_k127_2975649_0	1313172.YM304_29200	8.408e-237	749.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_2975649_1	1313172.YM304_29210	1.166e-223	708.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_2975649_20	1313172.YM304_19670	4.356e-29	118.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_2975649_19	1313172.YM304_29220	1.241e-33	132.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HFD2_k127_2975649_21	1313172.YM304_29250	6.633e-28	116.0	COG4339@1|root,COG4339@2|Bacteria,2HH0H@201174|Actinobacteria,4CP0S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF4031)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031
HFD2_k127_2975649_16	1313172.YM304_29260	5.267e-41	161.0	COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031,HD
HFD2_k127_2975649_14	1313172.YM304_29340	2.667e-52	189.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4743,NUDIX
HFD2_k127_2975649_8	670487.Ocepr_2148	2.219e-99	334.0	COG0524@1|root,COG0524@2|Bacteria,1WJRH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_2975649_10	134676.ACPL_2014	2.002e-88	301.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD2_k127_2975649_27	471853.Bcav_3887	5.984e-13	79.0	COG3173@1|root,COG3173@2|Bacteria,2I5FU@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_2975649_17	1121920.AUAU01000006_gene254	9.418e-36	140.0	COG2403@1|root,COG2403@2|Bacteria,3Y6GM@57723|Acidobacteria	57723|Acidobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2985415_5	1068978.AMETH_5477	1.46e-50	184.0	COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4DX6T@85010|Pseudonocardiales	201174|Actinobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HFD2_k127_2985415_4	1313172.YM304_24130	4.575e-114	370.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2985415_2	1313172.YM304_24120	6.557e-140	458.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_2985415_3	1313172.YM304_24100	8.603e-115	392.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4CN3C@84992|Acidimicrobiia	84992|Acidimicrobiia	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HFD2_k127_2985415_1	1313172.YM304_41890	5.812e-226	711.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2985415_0	1313172.YM304_24080	1.976e-254	793.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CNF1@84992|Acidimicrobiia	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2985415_6	1313172.YM304_24030	1.848e-32	127.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_2998832_6	398767.Glov_1262	3.767e-149	487.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	mdh	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HFD2_k127_2998832_30	83406.HDN1F_10410	0.0002283	53.0	COG1960@1|root,COG1960@2|Bacteria,1R81V@1224|Proteobacteria,1SM92@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_2998832_23	196162.Noca_0219	2.305e-42	163.0	COG1309@1|root,COG1309@2|Bacteria,2GKU3@201174|Actinobacteria,4DS6K@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HFD2_k127_2998832_4	402881.Plav_1785	1.193e-162	525.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,1JQ3T@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
HFD2_k127_2998832_20	525904.Tter_2866	3.801e-53	208.0	COG0726@1|root,COG3103@1|root,COG0726@2|Bacteria,COG4991@2|Bacteria,2NPV2@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	pdaA	-	3.5.1.104,3.5.1.28	ko:K01448,ko:K22278	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,LysM,Polysacc_deac_1,SH3_3
HFD2_k127_2998832_7	66429.JOFL01000020_gene5547	1.981e-134	435.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HFD2_k127_2998832_28	446468.Ndas_1111	6.346e-15	88.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EJD9@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_2998832_25	1313172.YM304_28250	1.71e-36	150.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_2998832_14	1122611.KB903953_gene5713	9.5e-94	317.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4EI49@85012|Streptosporangiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_2998832_17	479433.Caci_1488	1.083e-54	205.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria	201174|Actinobacteria	Q	Pfam Isochorismatase	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD2_k127_2998832_1	1429046.RR21198_5368	9.316e-193	614.0	COG1690@1|root,COG1690@2|Bacteria,2GIUP@201174|Actinobacteria,4FWT0@85025|Nocardiaceae	201174|Actinobacteria	L	tRNA-splicing ligase RtcB	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD2_k127_2998832_22	136273.GY22_16805	3.134e-44	167.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,1W9G6@1268|Micrococcaceae	201174|Actinobacteria	CO	Belongs to the thioredoxin family	trxA	-	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
HFD2_k127_2998832_21	43354.JOIJ01000018_gene4760	3.641e-49	179.0	COG0346@1|root,COG0346@2|Bacteria,2IM43@201174|Actinobacteria,4E74N@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_2998832_19	1869.MB27_27140	1.773e-53	190.0	COG2315@1|root,COG2315@2|Bacteria,2I2W9@201174|Actinobacteria,4DMDT@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD2_k127_2998832_18	1122939.ATUD01000001_gene187	3.435e-54	216.0	COG3342@1|root,COG3342@2|Bacteria,2HWBG@201174|Actinobacteria,4CP6I@84995|Rubrobacteria	84995|Rubrobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HFD2_k127_2998832_3	1386089.N865_04695	1.738e-169	551.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,4FFVM@85021|Intrasporangiaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
HFD2_k127_2998832_0	1386089.N865_04690	7.366e-259	809.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4FFVK@85021|Intrasporangiaceae	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
HFD2_k127_2998832_10	479431.Namu_3959	4.667e-112	373.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4ERG7@85013|Frankiales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_2998832_29	345341.KUTG_00465	7.929e-14	75.0	2EC60@1|root,3364M@2|Bacteria,2GR61@201174|Actinobacteria	201174|Actinobacteria	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
HFD2_k127_2998832_2	1370120.AUWR01000008_gene527	1.782e-189	604.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,23CIC@1762|Mycobacteriaceae	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.11,4.1.1.25,4.1.2.27	ko:K01634,ko:K18933	ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071	M00100	R00489,R00736,R02464,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HFD2_k127_2998832_13	342113.DM82_6345	1.936e-98	341.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KDJU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinase, N-terminal domain protein	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_2998832_26	1089544.KB912942_gene6223	2.992e-25	113.0	COG1309@1|root,COG1309@2|Bacteria,2IDJT@201174|Actinobacteria,4DXUI@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_2998832_5	1116369.KB890024_gene208	2.395e-149	504.0	COG0747@1|root,COG0747@2|Bacteria,1MWR7@1224|Proteobacteria,2TS51@28211|Alphaproteobacteria,43MZR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_2998832_9	1410620.SHLA_9c000790	1.257e-115	381.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,4BCMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2998832_11	1547437.LL06_10940	3.955e-102	352.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria,43NA6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2998832_12	1287116.X734_16930	1.127e-100	347.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,43GXR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	oppD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_2998832_8	1210045.ALNP01000002_gene3926	1.204e-121	404.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_2998832_24	298655.KI912267_gene6862	9.077e-39	164.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKUC@201174|Actinobacteria,4EVJ1@85013|Frankiales	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,PAS,PAS_4,SpoIIE
HFD2_k127_2998832_15	1123258.AQXZ01000017_gene4107	1.401e-89	302.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4FYDM@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_2998832_16	1142394.PSMK_05020	1.593e-57	210.0	COG1573@1|root,COG1573@2|Bacteria,2IX6D@203682|Planctomycetes	203682|Planctomycetes	L	Domain of unknown function (DUF4130	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
HFD2_k127_2998832_27	1122609.AUGT01000033_gene590	4.531e-22	98.0	2B2IY@1|root,31V42@2|Bacteria,2GUYA@201174|Actinobacteria,4DS4M@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3104606_10	402612.FP0093	2.205e-06	50.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,1HWUS@117743|Flavobacteriia,2NTP3@237|Flavobacterium	976|Bacteroidetes	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_3104606_4	1313172.YM304_07470	6.495e-97	323.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HFD2_k127_3104606_0	1229780.BN381_130116	2.246e-284	893.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,3UX5K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD2_k127_3104606_6	1352941.M877_06840	2.669e-63	223.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria	201174|Actinobacteria	I	Pfam SNARE associated Golgi protein	yqjA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HFD2_k127_3104606_7	1313172.YM304_07330	1.063e-46	171.0	COG3255@1|root,COG3255@2|Bacteria,2IGUY@201174|Actinobacteria	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HFD2_k127_3104606_3	1313172.YM304_07320	9.92e-109	358.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_3104606_5	1313172.YM304_07310	1.497e-65	247.0	COG0813@1|root,COG0813@2|Bacteria,2GNT6@201174|Actinobacteria	201174|Actinobacteria	F	purine-nucleoside phosphorylase	deoD	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03784	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_3104606_2	604331.AUHY01000046_gene1815	1.602e-152	489.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HFD2_k127_3104606_9	765420.OSCT_1823	7.129e-27	126.0	2E0CW@1|root,32VZR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3104606_1	1313172.YM304_07260	1.887e-154	511.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_3112465_8	1463887.KL590017_gene6409	0.0001326	51.0	COG0726@1|root,COG0726@2|Bacteria,2I3D0@201174|Actinobacteria	201174|Actinobacteria	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3112465_7	710696.Intca_0240	4.989e-22	103.0	COG2385@1|root,COG2385@2|Bacteria	2|Bacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Amidase_2,Amidase_3,ChW,SpoIID
HFD2_k127_3112465_1	399742.Ent638_0156	1.709e-181	581.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,3X13N@547|Enterobacter	1236|Gammaproteobacteria	G	Belongs to the xylose isomerase family	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iECO26_1355.ECO26_5036,iPC815.YPO4038	-
HFD2_k127_3112465_6	1313172.YM304_07550	9.111e-31	135.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	rfbD	-	1.1.1.133,3.2.1.21	ko:K00067,ko:K05350	ko00460,ko00500,ko00521,ko00523,ko00940,ko01100,ko01110,ko01130,map00460,map00500,map00521,map00523,map00940,map01100,map01110,map01130	M00793	R00026,R02558,R02777,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00182,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_1,RmlD_sub_bind
HFD2_k127_3112465_3	1313172.YM304_07560	2.668e-79	269.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD2_k127_3112465_0	1313172.YM304_07620	4.12e-321	993.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4CMU5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3112465_2	479432.Sros_3413	1.134e-92	332.0	COG0421@1|root,COG0421@2|Bacteria,2I3HX@201174|Actinobacteria,4EHKS@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD2_k127_3112465_5	1343740.M271_02355	6.721e-31	133.0	COG1802@1|root,COG1802@2|Bacteria,2HS3R@201174|Actinobacteria	201174|Actinobacteria	K	gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_3112465_4	1043205.AFYF01000030_gene503	1.653e-68	239.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FENX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_3133879_2	1313172.YM304_37200	3.891e-133	434.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_3133879_5	1123269.NX02_26270	7.14e-25	114.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2K40S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HFD2_k127_3133879_1	1313172.YM304_37190	2.403e-144	476.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HFD2_k127_3133879_3	1313172.YM304_37180	2.729e-125	422.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1,9.B.62.2	-	-	CopC,CopD
HFD2_k127_3133879_0	1313172.YM304_37160	8.309e-186	596.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CMQ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HFD2_k127_3133879_4	1313172.YM304_37150	5.787e-38	158.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CN1B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HFD2_k127_3139154_18	1146883.BLASA_0789	6.125e-10	60.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4ERCZ@85013|Frankiales	201174|Actinobacteria	L	uracil-DNA glycosylase	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_3139154_8	1313172.YM304_10030	4.34e-109	361.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4CNXU@84992|Acidimicrobiia	84992|Acidimicrobiia	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_3139154_11	392499.Swit_3100	4.634e-94	331.0	COG1520@1|root,COG1520@2|Bacteria,1R4I1@1224|Proteobacteria,2U05B@28211|Alphaproteobacteria,2K9NV@204457|Sphingomonadales	204457|Sphingomonadales	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3139154_5	1313172.YM304_01590	5.188e-140	450.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HFD2_k127_3139154_7	1313172.YM304_01570	4.881e-123	411.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_3139154_6	196162.Noca_1630	1.255e-139	452.0	COG2141@1|root,COG2141@2|Bacteria,2GNQ3@201174|Actinobacteria,4DT50@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD2_k127_3139154_0	1184607.AUCHE_05_04270	0.0	1436.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HFD2_k127_3139154_9	926550.CLDAP_36880	1.269e-102	351.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD2_k127_3139154_12	1123075.AUDP01000050_gene117	3.161e-85	296.0	COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes,24ZY6@186801|Clostridia,3WJY7@541000|Ruminococcaceae	186801|Clostridia	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_3139154_10	1313172.YM304_22760	3.396e-102	345.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria	201174|Actinobacteria	P	membrane protein terC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HFD2_k127_3139154_2	1313172.YM304_10050	1.323e-216	676.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
HFD2_k127_3139154_16	1313172.YM304_10100	6.775e-45	166.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD2_k127_3139154_3	1229780.BN381_350049	6.13e-196	624.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,3UW7B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD2_k127_3139154_14	886293.Sinac_0383	4.58e-61	243.0	COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes	203682|Planctomycetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD2_k127_3139154_1	1313172.YM304_10130	2.655e-222	695.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria	2|Bacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_3139154_13	1313172.YM304_10150	3.161e-83	300.0	COG0477@1|root,COG2814@2|Bacteria,2I8HS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HFD2_k127_3139154_4	1246448.ANAZ01000009_gene2661	3.333e-177	567.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria,4EGE3@85012|Streptosporangiales	201174|Actinobacteria	FL	AlkA N-terminal domain	ada	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HFD2_k127_3139154_15	1313172.YM304_10170	4.78e-61	214.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4CN9C@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
HFD2_k127_3149671_6	1068978.AMETH_6625	3.988e-43	157.0	COG3795@1|root,COG3795@2|Bacteria,2IFD6@201174|Actinobacteria,4E2TW@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_3149671_0	1155718.KB891940_gene4685	1.335e-172	548.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigI	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3149671_7	1397528.Q671_17240	1.629e-40	154.0	arCOG14922@1|root,32SW8@2|Bacteria,1N0NY@1224|Proteobacteria,1S5XN@1236|Gammaproteobacteria,1XPV3@135619|Oceanospirillales	135619|Oceanospirillales	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
HFD2_k127_3149671_5	1229780.BN381_70131	1.646e-55	203.0	COG2346@1|root,COG2346@2|Bacteria,2IJM0@201174|Actinobacteria	201174|Actinobacteria	S	COG2346, Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_3149671_2	1229780.BN381_170012	5.932e-82	280.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria	201174|Actinobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HFD2_k127_3149671_4	1229780.BN381_70129	1.247e-71	251.0	COG2345@1|root,COG2345@2|Bacteria,2GQ3A@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_3149671_10	1385521.N803_14435	5.763e-17	87.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_3149671_1	1121952.ATXT01000014_gene1329	2.086e-123	414.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GPUP@201174|Actinobacteria,4FN3E@85023|Microbacteriaceae	201174|Actinobacteria	PQ	Cupredoxin-like domain	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
HFD2_k127_3149671_9	937777.Deipe_0616	5.547e-23	117.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.4,4.1.3.1	ko:K01179,ko:K01637	ko00500,ko00630,ko01100,ko01110,ko01120,ko01200,map00500,map00630,map01100,map01110,map01120,map01200	M00012	R00479,R06200,R11307,R11308	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	GH5,GH9	-	Kelch_1,Laminin_G_3,Malectin,PKD,TIG
HFD2_k127_3149671_8	1150398.JIBJ01000022_gene3745	2.688e-35	158.0	COG5184@1|root,COG5184@2|Bacteria,2IG31@201174|Actinobacteria	201174|Actinobacteria	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RCC1
HFD2_k127_3149671_11	1120959.ATXF01000005_gene1330	1.683e-06	63.0	COG3291@1|root,COG4719@1|root,COG3291@2|Bacteria,COG4719@2|Bacteria,2I5PU@201174|Actinobacteria	201174|Actinobacteria	M	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36
HFD2_k127_3170586_9	1120950.KB892744_gene2840	5.075e-49	177.0	COG3795@1|root,COG3795@2|Bacteria,2IQMR@201174|Actinobacteria,4DVG6@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3,YCII
HFD2_k127_3170586_2	1380391.JIAS01000013_gene3464	2.375e-118	392.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JSGW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	ko:K22303	-	-	-	-	ko00000,ko01000	-	-	-	TauD
HFD2_k127_3170586_7	1122622.ATWJ01000009_gene3319	6.844e-64	225.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria,4FGSP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD2_k127_3170586_1	1385518.N798_03700	1.264e-164	547.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4FJ4K@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_3170586_3	35754.JNYJ01000013_gene1145	1.152e-116	390.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycosidase, PH1107-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
HFD2_k127_3170586_10	1463936.JOJI01000021_gene421	2.053e-44	168.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_3170586_15	994479.GL877878_gene1173	6.754e-10	70.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4E65M@85010|Pseudonocardiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_3170586_4	1122221.JHVI01000001_gene1780	5.88e-94	327.0	COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1WM9F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
HFD2_k127_3170586_12	1449355.JQNR01000003_gene547	2.759e-38	163.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K01173	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	FAD_oxidored,FTP,PPC,Peptidase_M4,Peptidase_M4_C,Peptidase_S8,SLH,VCBS
HFD2_k127_3170586_14	1313172.YM304_16310	2.303e-23	116.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,Lipase_GDSL_2,PT-HINT,RHS_repeat,Ricin_B_lectin
HFD2_k127_3170586_8	1380390.JIAT01000009_gene1585	8.2e-63	220.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria,4CSRP@84995|Rubrobacteria	84995|Rubrobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
HFD2_k127_3170586_11	1283283.ATXA01000001_gene375	3.658e-42	161.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4ET7H@85013|Frankiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_3170586_0	1160718.SU9_27504	3.809e-167	534.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3170586_6	1380390.JIAT01000001_gene5019	1.9e-68	255.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4CRF3@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HFD2_k127_3170586_5	1122182.KB903833_gene5580	6.255e-94	320.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4D8SS@85008|Micromonosporales	201174|Actinobacteria	V	resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_3170586_13	710111.FraQA3DRAFT_3068	2.653e-30	139.0	COG1309@1|root,COG1309@2|Bacteria,2IP7V@201174|Actinobacteria,4EX8Z@85013|Frankiales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HFD2_k127_3170586_16	1112204.GPOL_c48660	1.077e-09	60.0	2EK8X@1|root,33DZ6@2|Bacteria,2HXF8@201174|Actinobacteria,4GFIT@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3170965_2	768066.HELO_3159	1.824e-64	229.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RPTS@1236|Gammaproteobacteria,1XJCD@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_3170965_6	390989.JOEG01000015_gene2866	7.43e-07	59.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_3170965_0	1382356.JQMP01000003_gene1584	9.787e-230	741.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD2_k127_3170965_4	106370.Francci3_1002	2.059e-34	139.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria	201174|Actinobacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
HFD2_k127_3170965_1	1218074.BAXZ01000006_gene1589	4.746e-89	295.0	COG3631@1|root,COG3631@2|Bacteria,1N67H@1224|Proteobacteria,2W285@28216|Betaproteobacteria,1K81V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_3170965_3	1449347.JQLN01000007_gene1630	6.105e-61	229.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
HFD2_k127_3170965_5	1306174.JODP01000011_gene6700	2.986e-29	125.0	COG1595@1|root,COG1595@2|Bacteria,2GTC7@201174|Actinobacteria	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_317931_15	1313172.YM304_37820	2.82e-69	249.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF3253,DUF4214
HFD2_k127_317931_29	743718.Isova_2861	2.163e-08	67.0	COG1587@1|root,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4F4Y0@85017|Promicromonosporaceae	201174|Actinobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HFD2_k127_317931_11	1313172.YM304_37840	3.728e-92	312.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4CN1F@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD2_k127_317931_2	1313172.YM304_37850	2.379e-152	492.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4CN61@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HFD2_k127_317931_10	1313172.YM304_37860	2.375e-97	323.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HFD2_k127_317931_27	1382306.JNIM01000001_gene2815	5.728e-12	76.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_317931_4	1229780.BN381_60045	3.359e-129	430.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,3UWG3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	IQ	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_317931_8	1313172.YM304_37870	5.171e-106	354.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria	201174|Actinobacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HFD2_k127_317931_16	1229780.BN381_60047	2.427e-66	235.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,3UWS1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HFD2_k127_317931_20	1313172.YM304_37890	1.199e-45	187.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
HFD2_k127_317931_1	1313172.YM304_37900	7.17e-159	511.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4CMYV@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_317931_25	1193181.BN10_890019	1.645e-30	132.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4FGUQ@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD2_k127_317931_21	1313172.YM304_37910	4.675e-41	156.0	2DP8R@1|root,32UKH@2|Bacteria	2|Bacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_317931_26	1229780.BN381_60052	2.389e-20	92.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD2_k127_317931_23	446462.Amir_0937	5.895e-39	151.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4E307@85010|Pseudonocardiales	201174|Actinobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HFD2_k127_317931_17	1313172.YM304_37930	7.722e-59	214.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4CN2J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HFD2_k127_317931_24	1229780.BN381_100131	9.587e-32	139.0	COG4242@1|root,COG4242@2|Bacteria	2|Bacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HFD2_k127_317931_13	1313172.YM304_37950	1.504e-74	259.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4CNVE@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase3
HFD2_k127_317931_19	1123320.KB889562_gene6601	3.71e-48	188.0	COG1896@1|root,COG1896@2|Bacteria,2GN7A@201174|Actinobacteria	201174|Actinobacteria	S	of HD superfamily	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
HFD2_k127_317931_9	1313172.YM304_38120	4.752e-103	342.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4CNMA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_317931_12	1122609.AUGT01000020_gene1060	9.01e-76	260.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4DQD7@85009|Propionibacteriales	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HFD2_k127_317931_0	1313172.YM304_38140	3.333e-314	973.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CMVR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HFD2_k127_317931_7	1313172.YM304_38730	2.815e-122	394.0	2EWQK@1|root,33Q2D@2|Bacteria,2IJ4T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_317931_31	1128421.JAGA01000003_gene2904	8.939e-06	58.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF928,LysM
HFD2_k127_317931_3	1313172.YM304_38750	4.337e-135	436.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_317931_14	1313172.YM304_38760	1.851e-71	252.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,NAD_binding_4
HFD2_k127_317931_22	1313172.YM304_18810	1.26e-39	171.0	COG3857@1|root,COG3857@2|Bacteria,2I6QC@201174|Actinobacteria	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HFD2_k127_317931_6	1120948.KB903230_gene4922	1.227e-124	441.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_317931_18	426117.M446_3468	5.781e-58	209.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,1JU0F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM class II aldolase adducin family protein	MA20_30505	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_317931_30	385682.AFSL01000095_gene822	4.332e-06	56.0	COG1722@1|root,COG1722@2|Bacteria,4NXJV@976|Bacteroidetes,2FVH6@200643|Bacteroidia,3XKF5@558415|Marinilabiliaceae	976|Bacteroidetes	L	Exonuclease VII small subunit	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD2_k127_317931_5	1313172.YM304_37370	2.553e-128	423.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CNA1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD2_k127_3246434_14	1151122.AQYD01000007_gene1016	1.849e-30	133.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
HFD2_k127_3246434_1	1299327.I546_3485	3.563e-193	617.0	COG1020@1|root,COG1020@2|Bacteria,2IGNH@201174|Actinobacteria	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_3246434_0	1380347.JNII01000008_gene4392	9.545e-217	685.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4ETB2@85013|Frankiales	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
HFD2_k127_3246434_12	479431.Namu_3002	6.042e-43	167.0	29RUH@1|root,30CYE@2|Bacteria,2HHM4@201174|Actinobacteria,4ET32@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3246434_7	1041159.AZUW01000004_gene5584	7.088e-98	332.0	2EJYA@1|root,33DNX@2|Bacteria,1NTYZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3246434_8	1267535.KB906767_gene3812	5.898e-73	259.0	2EPXI@1|root,33HI2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3246434_6	1150626.PHAMO_210276	6.215e-131	429.0	2CHC4@1|root,2ZEVG@2|Bacteria,1P4GV@1224|Proteobacteria,2UYJH@28211|Alphaproteobacteria,2JY9U@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3246434_13	1380347.JNII01000008_gene4391	4.332e-34	135.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_3246434_5	1121272.KB903290_gene4486	2.849e-133	441.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DBHX@85008|Micromonosporales	201174|Actinobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HFD2_k127_3246434_9	1121939.L861_01745	1.346e-70	243.0	COG1765@1|root,COG1765@2|Bacteria,1QUE7@1224|Proteobacteria,1S84Z@1236|Gammaproteobacteria,1XKED@135619|Oceanospirillales	135619|Oceanospirillales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_3246434_3	1121952.ATXT01000013_gene2211	1.633e-157	507.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4FNRY@85023|Microbacteriaceae	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
HFD2_k127_3246434_4	1380356.JNIK01000017_gene2797	1.436e-156	504.0	COG0654@1|root,COG0654@2|Bacteria,2I2TH@201174|Actinobacteria,4EXES@85013|Frankiales	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_3246434_2	1380356.JNIK01000017_gene2798	5.803e-182	584.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,4ESTX@85013|Frankiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_19
HFD2_k127_3246434_11	479431.Namu_2023	7.19e-57	205.0	2DW3A@1|root,33YCP@2|Bacteria,2GZ8M@201174|Actinobacteria,4EVKN@85013|Frankiales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_3246434_10	479431.Namu_2024	2.996e-61	218.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4EVJY@85013|Frankiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_3246434_15	1313172.YM304_37270	5.992e-28	122.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,4CP4N@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HFD2_k127_3246434_16	1380390.JIAT01000010_gene4390	2.609e-05	49.0	COG2931@1|root,COG2931@2|Bacteria,2GYC8@201174|Actinobacteria	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
HFD2_k127_3319922_0	909613.UO65_1996	7.489e-148	482.0	COG1249@1|root,COG1249@2|Bacteria,2GNSR@201174|Actinobacteria,4DZ6N@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	mtr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657	1.8.1.15	ko:K17883	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_3319922_1	1380391.JIAS01000020_gene1630	1.552e-91	316.0	COG2175@1|root,COG2175@2|Bacteria,1MX7P@1224|Proteobacteria,2TSWR@28211|Alphaproteobacteria,2JSRG@204441|Rhodospirillales	1224|Proteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF971,TauD
HFD2_k127_3319922_2	1229780.BN381_350016	1.301e-74	256.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria,3UWS4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3319922_3	247490.KSU1_B0116	3.783e-31	130.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3360951_0	1535287.JP74_01885	4.408e-133	437.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2TR9B@28211|Alphaproteobacteria,3N886@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
HFD2_k127_3360951_2	639283.Snov_2545	2.378e-105	348.0	COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VET1@28211|Alphaproteobacteria,3EZMK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
HFD2_k127_3360951_3	1229780.BN381_80233	5.473e-87	311.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
HFD2_k127_3360951_1	1828.JOKB01000019_gene1465	8.35e-112	368.0	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria,4FZPC@85025|Nocardiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD2_k127_3360951_5	1463920.JOGB01000070_gene5764	5.116e-54	199.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HFD2_k127_3360951_4	2002.JOEQ01000016_gene7312	2.049e-62	225.0	COG0262@1|root,COG0262@2|Bacteria,2GJJD@201174|Actinobacteria,4EQTB@85012|Streptosporangiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_3524092_0	471852.Tcur_1080	1.984e-281	872.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria,4EG9D@85012|Streptosporangiales	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fum	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HFD2_k127_3524092_10	1221522.B723_24690	1.974e-33	139.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,1S5DU@1236|Gammaproteobacteria,1YRFX@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_3524092_6	882083.SacmaDRAFT_4482	4.303e-52	199.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4E1PA@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_3524092_2	1035308.AQYY01000001_gene3641	6.126e-221	695.0	COG1328@1|root,COG1328@2|Bacteria,1TPAC@1239|Firmicutes,24A2W@186801|Clostridia	186801|Clostridia	F	glycine radical enzyme, YjjI family	yjjI	-	-	-	-	-	-	-	-	-	-	-	DUF3029
HFD2_k127_3524092_5	1122963.AUHB01000007_gene3528	6.532e-70	246.0	COG1180@1|root,COG1180@2|Bacteria,1QIC8@1224|Proteobacteria,2TSN0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HFD2_k127_3524092_1	1313172.YM304_13880	5.69e-241	755.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CNIJ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD2_k127_3524092_8	931626.Awo_c20220	5.045e-42	166.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HFD2_k127_3524092_9	1313172.YM304_13870	8.22e-42	168.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	ChitinaseA_N,Lipase_GDSL_2
HFD2_k127_3524092_11	391603.FBALC1_16657	5.543e-21	102.0	COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,1I33I@117743|Flavobacteriia	976|Bacteroidetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HFD2_k127_3524092_7	765420.OSCT_3060	6.572e-44	169.0	COG0739@1|root,COG0739@2|Bacteria,2GADD@200795|Chloroflexi,375JT@32061|Chloroflexia	32061|Chloroflexia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD2_k127_3524092_4	1313172.YM304_17270	2.446e-103	350.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_3564751_10	1313172.YM304_30920	3.089e-122	400.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_3564751_15	1128421.JAGA01000002_gene1691	3.007e-81	290.0	COG3694@1|root,COG3694@2|Bacteria,2NQKI@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HFD2_k127_3564751_12	1128421.JAGA01000002_gene1692	9.03e-104	344.0	COG4587@1|root,COG4587@2|Bacteria	2|Bacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HFD2_k127_3564751_9	1128421.JAGA01000002_gene1693	2.363e-126	412.0	COG4586@1|root,COG4586@2|Bacteria,2NP49@2323|unclassified Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_3564751_17	525904.Tter_1708	2.587e-73	257.0	COG1606@1|root,COG1606@2|Bacteria,2NP5T@2323|unclassified Bacteria	2|Bacteria	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
HFD2_k127_3564751_5	1313172.YM304_15740	1.877e-150	483.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4CMWM@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3564751_13	1313172.YM304_26570	3.916e-99	351.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_3564751_14	1313172.YM304_15750	9.641e-97	326.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HFD2_k127_3564751_11	1313172.YM304_15760	7.932e-111	366.0	COG1721@1|root,COG1721@2|Bacteria,2GKSJ@201174|Actinobacteria	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_3564751_4	1313172.YM304_15770	1.955e-151	486.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	moxR1	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_3564751_1	1313172.YM304_12820	1.734e-206	655.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4CMU6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_3564751_8	1229780.BN381_10277	1.769e-128	422.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,3UXGG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HFD2_k127_3564751_3	1313172.YM304_15790	7.077e-159	514.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_3564751_6	1313172.YM304_15810	2.271e-149	477.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_3564751_7	1313172.YM304_15820	8.854e-129	417.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	htdY	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HFD2_k127_3564751_20	1123320.KB889627_gene7913	3.556e-05	54.0	2BEUS@1|root,328KD@2|Bacteria,2HEDT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3564751_0	1120950.KB892747_gene3709	3.603e-273	851.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4DN8W@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HFD2_k127_3564751_18	1313172.YM304_15870	2.785e-50	185.0	COG0779@1|root,COG0779@2|Bacteria,2HH26@201174|Actinobacteria,4CP28@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD2_k127_3564751_2	1313172.YM304_15880	1.641e-194	621.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HFD2_k127_3564751_19	1232429.CBLL010000067_gene1668	3.384e-10	66.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,1WA8F@1268|Micrococcaceae	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HFD2_k127_3568329_6	1313172.YM304_10600	8.703e-29	117.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4CNBJ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD2_k127_3568329_5	1313172.YM304_10610	1.326e-32	137.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_3568329_4	1313172.YM304_10620	9.149e-39	152.0	COG0711@1|root,COG0711@2|Bacteria,2HGQ4@201174|Actinobacteria,4CNSS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_3568329_3	1313172.YM304_10630	4.565e-73	259.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD2_k127_3568329_0	1313172.YM304_10640	7.511e-269	840.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CMTI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD2_k127_3568329_2	1313172.YM304_10650	9.699e-131	424.0	COG0224@1|root,COG3743@1|root,COG0224@2|Bacteria,COG3743@2|Bacteria,2GJ7Q@201174|Actinobacteria,4CN1H@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HFD2_k127_3568329_1	1313172.YM304_10660	1.092e-159	510.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD2_k127_363310_4	649638.Trad_0704	9.767e-12	77.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1WM34@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CE	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HFD2_k127_363310_3	926569.ANT_28220	4.945e-46	184.0	COG1470@1|root,COG1470@2|Bacteria,2G5KU@200795|Chloroflexi	200795|Chloroflexi	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
HFD2_k127_363310_0	1408254.T458_21965	3.107e-96	325.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,4H9RS@91061|Bacilli,26VBR@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_363310_1	357808.RoseRS_3208	1.378e-66	239.0	COG1277@1|root,COG1277@2|Bacteria,2G5RT@200795|Chloroflexi,3766G@32061|Chloroflexia	32061|Chloroflexia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD2_k127_363310_2	1380390.JIAT01000010_gene4003	8.366e-55	211.0	COG0642@1|root,COG2205@2|Bacteria,2I3HN@201174|Actinobacteria,4CR25@84995|Rubrobacteria	84995|Rubrobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_363310_5	479431.Namu_4223	1.866e-09	63.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,4EV89@85013|Frankiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	vicR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3642274_26	1122609.AUGT01000021_gene1147	1.706e-37	142.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DSY6@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_3642274_3	631454.N177_3523	1.215e-159	526.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,1JQ0P@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA binding domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD2_k127_3642274_18	1089551.KE386572_gene2815	2.077e-75	264.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,4BQEZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	caiD	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
HFD2_k127_3642274_20	1144275.COCOR_00021	2.265e-64	236.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD2_k127_3642274_5	1313172.YM304_23900	9.247e-141	454.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	desA	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HFD2_k127_3642274_13	1313172.YM304_33850	2.185e-90	312.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	eis	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009605,GO:0009607,GO:0009987,GO:0010941,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0031347,GO:0031349,GO:0032101,GO:0032103,GO:0034069,GO:0035821,GO:0040007,GO:0042802,GO:0043067,GO:0043207,GO:0044003,GO:0044068,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044248,GO:0044403,GO:0044419,GO:0044531,GO:0048518,GO:0048583,GO:0048584,GO:0050727,GO:0050729,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052032,GO:0052035,GO:0052040,GO:0052164,GO:0052167,GO:0052173,GO:0052200,GO:0052248,GO:0052255,GO:0052256,GO:0052259,GO:0052303,GO:0052306,GO:0052509,GO:0052510,GO:0052550,GO:0052552,GO:0052553,GO:0052564,GO:0052567,GO:0052572,GO:0065007,GO:0071704,GO:0075136,GO:0080134,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
HFD2_k127_3642274_7	926554.KI912637_gene3217	1.981e-123	410.0	COG0624@1|root,COG0624@2|Bacteria,1WKXT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
HFD2_k127_3642274_0	1313172.YM304_33800	8.504e-214	683.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4CMV1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD2_k127_3642274_1	1313172.YM304_33810	1.43e-212	669.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4CMQJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_3642274_28	1313172.YM304_33820	1.668e-29	134.0	COG0721@1|root,COG0721@2|Bacteria,2HH3E@201174|Actinobacteria,4CP3G@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HFD2_k127_3642274_16	58344.JOEL01000036_gene4121	3.585e-82	291.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
HFD2_k127_3642274_17	1313172.YM304_33890	5.147e-80	274.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria	201174|Actinobacteria	S	Esterase	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HFD2_k127_3642274_21	1313172.YM304_33900	7.318e-52	185.0	COG1149@1|root,COG1149@2|Bacteria,2IMA0@201174|Actinobacteria	201174|Actinobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_21,Fer4_4
HFD2_k127_3642274_6	1313172.YM304_33920	2.201e-128	445.0	COG0457@1|root,COG3437@1|root,COG0457@2|Bacteria,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CP5F@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	-
HFD2_k127_3642274_15	1313172.YM304_33930	2.045e-89	304.0	COG0501@1|root,COG0501@2|Bacteria,2GTHQ@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase family M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48
HFD2_k127_3642274_9	266117.Rxyl_1742	7.05e-119	393.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CP6S@84995|Rubrobacteria	84995|Rubrobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_3642274_11	42256.RradSPS_0763	1.596e-95	319.0	COG0842@1|root,COG0842@2|Bacteria,2IPQ3@201174|Actinobacteria,4CT8V@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_3642274_23	1121272.KB903283_gene4861	5.693e-48	181.0	COG2318@1|root,COG2318@2|Bacteria,2I3S3@201174|Actinobacteria,4DMJ0@85008|Micromonosporales	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Pentapeptide
HFD2_k127_3642274_22	1449353.JQMQ01000005_gene4855	1.129e-50	185.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,2NI5Q@228398|Streptacidiphilus	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_3642274_12	1313172.YM304_07180	2.284e-95	320.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	rutA_3	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3642274_14	1380394.JADL01000002_gene1281	2.598e-90	304.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria,2JQV5@204441|Rhodospirillales	204441|Rhodospirillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_3642274_24	1380390.JIAT01000009_gene1077	2.133e-44	176.0	COG0599@1|root,COG0599@2|Bacteria,2IM8G@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Carboxymuconolactone decarboxylase	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_3642274_19	298653.Franean1_1631	9.101e-67	243.0	COG2084@1|root,COG2084@2|Bacteria,2I9EJ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_3642274_10	1048339.KB913029_gene2164	1.28e-105	352.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4EVCM@85013|Frankiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_3642274_2	1313172.YM304_12030	6.129e-196	627.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_3642274_25	37919.EP51_00060	4.078e-44	163.0	COG3801@1|root,COG3801@2|Bacteria,2IHXB@201174|Actinobacteria,4G1R5@85025|Nocardiaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD2_k127_3642274_27	2074.JNYD01000055_gene2319	5.523e-35	145.0	COG3795@1|root,COG3795@2|Bacteria,2IQMR@201174|Actinobacteria,4E69V@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_3642274_8	1463917.JODC01000001_gene196	1.997e-121	409.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3642274_4	1379270.AUXF01000002_gene1452	2.12e-147	473.0	COG1171@1|root,COG1171@2|Bacteria,1ZTBP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_3642274_29	357808.RoseRS_1431	1.286e-15	91.0	COG0454@1|root,COG0456@2|Bacteria,2G92V@200795|Chloroflexi,377JP@32061|Chloroflexia	32061|Chloroflexia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_3642274_30	710111.FraQA3DRAFT_3338	7.151e-10	59.0	COG0604@1|root,COG0604@2|Bacteria,2GRJM@201174|Actinobacteria,4ETQB@85013|Frankiales	201174|Actinobacteria	C	Zn-dependent oxidoreductase, NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_3684026_13	1313172.YM304_09060	6.251e-90	317.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
HFD2_k127_3684026_7	1313172.YM304_09070	2.186e-129	424.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thioesterase-like superfamily	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
HFD2_k127_3684026_18	1380356.JNIK01000014_gene3116	5.275e-26	123.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_3684026_12	1313172.YM304_09090	8.271e-93	311.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,4CN8Q@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HFD2_k127_3684026_2	526225.Gobs_1939	2.62e-205	651.0	COG1012@1|root,COG1012@2|Bacteria,2GT45@201174|Actinobacteria,4EUMT@85013|Frankiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	pcd	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_3684026_20	1229780.BN381_330009	1.499e-09	64.0	2FIWN@1|root,34AMS@2|Bacteria,2H89S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3684026_3	1313172.YM304_09250	4.303e-156	501.0	COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,4CN1W@84992|Acidimicrobiia	84992|Acidimicrobiia	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3684026_11	1313172.YM304_09260	6.502e-95	332.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_3684026_1	1313172.YM304_09270	9.247e-216	676.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4CMVF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD2_k127_3684026_15	1211114.ALIP01000069_gene305	4.226e-65	231.0	COG2017@1|root,COG2017@2|Bacteria,1N5HJ@1224|Proteobacteria,1S9UC@1236|Gammaproteobacteria,1X2ZF@135614|Xanthomonadales	135614|Xanthomonadales	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HFD2_k127_3684026_16	1313172.YM304_09310	6.733e-52	188.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HFD2_k127_3684026_4	1313172.YM304_09320	5.471e-152	496.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_3684026_17	1313172.YM304_09330	8.304e-44	179.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_3684026_8	1313172.YM304_09340	4.635e-125	432.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4CN93@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Flavin containing amine oxidoreductase	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_3684026_14	485913.Krac_1479	1.141e-75	278.0	COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ferrous insertion into protoporphyrin IX	-	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD2_k127_3684026_6	1313172.YM304_09350	3.949e-141	456.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,4CMTU@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD2_k127_3684026_10	1313172.YM304_09420	5.505e-101	332.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HFD2_k127_3684026_0	1313172.YM304_09360	5.533e-301	938.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4CMUM@84992|Acidimicrobiia	84992|Acidimicrobiia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19
HFD2_k127_3684026_5	590998.Celf_2090	7.841e-147	471.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3684026_9	1313172.YM304_09490	5.056e-101	333.0	COG1201@1|root,COG1201@2|Bacteria,2I6VR@201174|Actinobacteria,4CNBF@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DEAD-like helicases superfamily	-	-	-	ko:K03724,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
HFD2_k127_3698889_10	1229780.BN381_140020	1.128e-65	234.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,3UWRA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_3698889_3	1313172.YM304_19330	1.804e-130	424.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4CNN6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_3698889_11	1313172.YM304_19320	8.787e-58	215.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4CP1F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_3698889_4	1313172.YM304_19310	3.035e-128	442.0	COG1305@1|root,COG1305@2|Bacteria,2HH1I@201174|Actinobacteria,4CP1R@84992|Acidimicrobiia	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
HFD2_k127_3698889_1	1313172.YM304_19290	8.826e-143	473.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CNR5@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD2_k127_3698889_12	1229780.BN381_140026	7.475e-31	127.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	MA20_41050	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HFD2_k127_3698889_7	1313172.YM304_25270	7.369e-70	266.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4CN03@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD2_k127_3698889_8	436229.JOEH01000019_gene6621	1.009e-66	241.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,2NER6@228398|Streptacidiphilus	201174|Actinobacteria	G	Inositol monophosphatase family	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_3698889_5	1313172.YM304_19260	1.52e-127	409.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3698889_0	1313172.YM304_19250	2.74e-151	494.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_3698889_14	877418.ATWV01000007_gene2278	1.146e-08	65.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HFD2_k127_3698889_6	1313172.YM304_12810	7.011e-98	338.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HFD2_k127_3698889_9	1313172.YM304_12800	2.098e-66	236.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HFD2_k127_3698889_2	1304865.JAGF01000001_gene3757	1.316e-137	442.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
HFD2_k127_3722147_6	1313172.YM304_10740	1.096e-32	130.0	COG2214@1|root,COG2214@2|Bacteria,2H5PV@201174|Actinobacteria	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3722147_5	1313172.YM304_10730	1.185e-39	160.0	294NP@1|root,2ZS20@2|Bacteria,2H9SR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3722147_0	1313172.YM304_10710	1.003e-175	571.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2HF92@201174|Actinobacteria,4CNT6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD2_k127_3722147_1	1313172.YM304_10700	4.729e-146	471.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4CMQH@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HFD2_k127_3722147_2	1394178.AWOO02000099_gene8310	2.167e-53	198.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4EGF3@85012|Streptosporangiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HFD2_k127_3722147_4	1313172.YM304_10670	9.568e-40	151.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1609	ATP-synt_DE,ATP-synt_DE_N
HFD2_k127_3722147_3	1313172.YM304_10660	4.539e-46	168.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD2_k127_3744161_15	1313172.YM304_20800	1.604e-21	108.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD2_k127_3744161_2	1313172.YM304_20790	2.027e-129	421.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4CMY2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_3744161_8	1313172.YM304_20770	5.207e-64	224.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HFD2_k127_3744161_6	298655.KI912266_gene600	2.541e-81	280.0	COG1396@1|root,COG1396@2|Bacteria,2IP35@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HFD2_k127_3744161_10	1079986.JH164848_gene1073	1.621e-55	209.0	COG2353@1|root,COG2353@2|Bacteria,2IH61@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_3744161_5	345341.KUTG_06859	4.197e-90	302.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria,4E3VZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_3744161_0	1313172.YM304_20720	1.321e-306	957.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4CMUN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HFD2_k127_3744161_1	1313172.YM304_20710	4.714e-132	428.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CMPG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HFD2_k127_3744161_11	1313172.YM304_20680	6.326e-55	210.0	COG0566@1|root,COG0566@2|Bacteria,2HGTD@201174|Actinobacteria,4CNZQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_3744161_12	1313172.YM304_20670	1.015e-47	173.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4CN4X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HFD2_k127_3744161_16	1313172.YM304_20660	6.552e-20	94.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HFD2_k127_3744161_7	1313172.YM304_20650	5.933e-71	245.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CMZR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HFD2_k127_3744161_13	1313172.YM304_20630	4.315e-28	117.0	2FH85@1|root,3492H@2|Bacteria,2H8HQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3744161_14	1313172.YM304_20620	2.874e-24	107.0	COG3695@1|root,COG3695@2|Bacteria	2|Bacteria	L	enzyme binding	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
HFD2_k127_3744161_3	1313172.YM304_20600	1.031e-128	419.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4CMTS@84992|Acidimicrobiia	84992|Acidimicrobiia	F	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HFD2_k127_3744161_9	1313172.YM304_20590	2.432e-56	209.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4CN1Q@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD2_k127_3744161_4	1313172.YM304_20580	4.819e-96	320.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD2_k127_377855_25	1211815.CBYP010000067_gene118	3.065e-37	142.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EU6B@85013|Frankiales	201174|Actinobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_377855_24	543632.JOJL01000021_gene1216	1.188e-39	154.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria,4DM4P@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_377855_21	1229780.BN381_150001	5.251e-60	228.0	COG1807@1|root,COG1807@2|Bacteria,2IITJ@201174|Actinobacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HFD2_k127_377855_11	1313172.YM304_25290	9.802e-103	345.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_377855_10	1313172.YM304_25280	3.083e-108	371.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria	201174|Actinobacteria	NT	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
HFD2_k127_377855_0	1313172.YM304_25220	0.0	1132.0	COG1807@1|root,COG1807@2|Bacteria,2I5WT@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF3367)	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	DUF3367
HFD2_k127_377855_23	1283283.ATXA01000003_gene1606	2.214e-43	167.0	COG0500@1|root,COG0500@2|Bacteria,2GNZU@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_377855_8	1449976.KALB_5584	2.309e-116	399.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4DZQE@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_377855_27	749927.AMED_3765	7.833e-25	121.0	COG2755@1|root,COG2755@2|Bacteria,2HKZD@201174|Actinobacteria,4E02I@85010|Pseudonocardiales	201174|Actinobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_377855_5	1283283.ATXA01000008_gene2989	1.392e-155	497.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_377855_2	1229780.BN381_310090	1.998e-203	682.0	COG1807@1|root,COG1835@1|root,COG1807@2|Bacteria,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	aftB	GO:0008150,GO:0040007	-	ko:K13687	-	-	-	-	ko00000,ko01000,ko01003	-	GT89	-	Acyl_transf_3,PMT_2
HFD2_k127_377855_19	935866.JAER01000003_gene1311	7.233e-76	285.0	COG0500@1|root,COG2226@2|Bacteria,2HEFM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_377855_15	1313172.YM304_25130	2.985e-87	294.0	COG0463@1|root,COG0463@2|Bacteria,2IPT1@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD2_k127_377855_17	1229780.BN381_310087	9.821e-80	289.0	28TMQ@1|root,33S62@2|Bacteria,2H3TK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_377855_3	1313172.YM304_25090	9.645e-158	508.0	COG0438@1|root,COG0438@2|Bacteria,2GK8D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_377855_20	675635.Psed_0194	7.685e-69	252.0	COG1028@1|root,COG1028@2|Bacteria,2I2RJ@201174|Actinobacteria,4E134@85010|Pseudonocardiales	201174|Actinobacteria	IQ	PFAM short chain dehydrogenase	dprE2	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576	1.1.1.333	ko:K16652	-	-	-	-	ko00000,ko01000	-	-	iNJ661.Rv3791	adh_short
HFD2_k127_377855_4	1120950.KB892742_gene3045	2.95e-156	509.0	COG0277@1|root,COG0277@2|Bacteria,2HZ5X@201174|Actinobacteria,4DNVZ@85009|Propionibacteriales	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	1.1.98.3	ko:K16653	-	-	-	-	ko00000,ko01000	-	-	-	ALO,FAD_binding_4
HFD2_k127_377855_9	1229780.BN381_40064	3.717e-113	398.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
HFD2_k127_377855_28	1193181.BN10_650046	1.359e-17	98.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4FFV2@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_377855_1	1122239.AULS01000002_gene706	6.682e-207	664.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FMWU@85023|Microbacteriaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_377855_26	330214.NIDE3754	2.524e-26	115.0	COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_377855_16	1313172.YM304_25030	1.111e-83	295.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HFD2_k127_377855_14	1313172.YM304_25020	6.643e-97	326.0	COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,4CNR9@84992|Acidimicrobiia	84992|Acidimicrobiia	H	UbiA prenyltransferase family	-	-	2.4.2.45	ko:K14136	-	-	R10095	RC00005	ko00000,ko01000,ko01006	-	-	-	UbiA
HFD2_k127_377855_7	1313172.YM304_25000	2.717e-135	458.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4CNB2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD2_k127_377855_6	1313172.YM304_24990	5.744e-136	441.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CNBS@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HFD2_k127_377855_12	1313172.YM304_24980	4.726e-101	335.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4CN36@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA pseudouridylate synthase	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_377855_18	1313172.YM304_24970	2.51e-76	260.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CN9J@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD2_k127_377855_13	1313172.YM304_24960	2.431e-100	334.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD2_k127_377855_22	1313172.YM304_24950	1.77e-49	179.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4CMTD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_3793345_5	1297581.H919_04529	5.973e-11	70.0	298S5@1|root,2ZVWF@2|Bacteria,1V8I3@1239|Firmicutes,4HHTT@91061|Bacilli,21VQA@150247|Anoxybacillus	91061|Bacilli	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
HFD2_k127_3793345_4	994573.T472_0205815	5.97e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,36FWV@31979|Clostridiaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3793345_2	35754.JNYJ01000089_gene6361	5.38e-80	285.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4DHBZ@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_3793345_6	1429046.RR21198_5362	5.864e-09	62.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria,4G49V@85025|Nocardiaceae	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HFD2_k127_3793345_0	593907.Celgi_0134	1.659e-90	312.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4F1UP@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_3793345_1	196162.Noca_3776	1.087e-87	315.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	devC	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3793345_3	397278.JOJN01000018_gene3515	1.336e-77	272.0	COG0577@1|root,COG0577@2|Bacteria,2HY9V@201174|Actinobacteria,4DTYD@85009|Propionibacteriales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HFD2_k127_3803593_41	1267535.KB906767_gene2916	1.762e-09	58.0	COG0277@1|root,COG0277@2|Bacteria,3Y36Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HFD2_k127_3803593_45	1122609.AUGT01000030_gene2543	0.0001619	49.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2GM1B@201174|Actinobacteria,4DTFJ@85009|Propionibacteriales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
HFD2_k127_3803593_36	373903.Hore_13850	1.938e-34	139.0	COG1573@1|root,COG1573@2|Bacteria,1V1SU@1239|Firmicutes,24E7B@186801|Clostridia	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HFD2_k127_3803593_20	298654.FraEuI1c_2727	1.658e-83	280.0	COG3576@1|root,COG3576@2|Bacteria,2I3NE@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_3803593_14	2074.JNYD01000005_gene3241	3.206e-109	356.0	COG0262@1|root,COG0262@2|Bacteria,2I8GU@201174|Actinobacteria,4EAHZ@85010|Pseudonocardiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_3803593_15	1463926.JOCA01000008_gene2339	1.476e-105	347.0	COG0262@1|root,COG0262@2|Bacteria,2I8GU@201174|Actinobacteria	201174|Actinobacteria	H	reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_3803593_11	1385519.N801_18145	2.642e-130	422.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,4FGZ1@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3803593_25	1150599.MPHLEI_03608	2.53e-62	227.0	COG1309@1|root,COG1309@2|Bacteria,2IJP2@201174|Actinobacteria,23F1N@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HFD2_k127_3803593_23	1206731.BAGB01000174_gene2039	2.007e-68	236.0	2C3KP@1|root,2Z802@2|Bacteria,2IFTZ@201174|Actinobacteria,4G0H7@85025|Nocardiaceae	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3803593_26	1183438.GKIL_3589	1.222e-61	224.0	COG3576@1|root,COG3576@2|Bacteria,1G2UH@1117|Cyanobacteria	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_3803593_34	713587.THITH_16915	1.045e-36	149.0	COG3370@1|root,COG3370@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HFD2_k127_3803593_38	67352.JODS01000003_gene1876	1.248e-19	96.0	COG5516@1|root,COG5516@2|Bacteria,2ID3R@201174|Actinobacteria	201174|Actinobacteria	S	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HFD2_k127_3803593_31	65497.JODV01000007_gene408	1.328e-48	178.0	COG1846@1|root,COG1846@2|Bacteria,2GP6A@201174|Actinobacteria,4E4U7@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_3803593_18	35754.JNYJ01000011_gene651	4.18e-87	291.0	COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria,4DCCU@85008|Micromonosporales	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HFD2_k127_3803593_8	1121946.AUAX01000002_gene129	1.608e-143	471.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4D9SB@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD2_k127_3803593_17	391037.Sare_4704	1.554e-101	348.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DB58@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_3803593_44	1206741.BAFX01000050_gene2271	7.463e-05	45.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FUTU@85025|Nocardiaceae	201174|Actinobacteria	K	activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC
HFD2_k127_3803593_35	1151119.KB895497_gene3304	1.735e-34	147.0	COG4319@1|root,COG4319@2|Bacteria,2H1H4@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD2_k127_3803593_32	331869.BAL199_29922	1.516e-44	168.0	COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria,2U7HF@28211|Alphaproteobacteria,4BT3J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent enzyme of the double-stranded beta helix superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3803593_33	1123024.AUII01000021_gene8	3.153e-42	163.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_3803593_13	1429046.RR21198_0390	3.648e-113	384.0	COG1131@1|root,COG1131@2|Bacteria,2H2U9@201174|Actinobacteria,4FYGN@85025|Nocardiaceae	201174|Actinobacteria	V	Protein involved in transcription factor activity, ATP binding, drug transporter activity, ATPase activity, metal ion binding, regulation of transcription, DNA-dependent, drug transport, metal ion transport, defense response to pathogen and response to antibiotic	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_3803593_16	1240349.ANGC01000051_gene4090	2.075e-104	348.0	COG0842@1|root,COG0842@2|Bacteria,2GX2M@201174|Actinobacteria,4FU46@85025|Nocardiaceae	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_3803593_7	644966.Tmar_0901	2.037e-157	521.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
HFD2_k127_3803593_1	1121920.AUAU01000021_gene2509	5.609e-206	650.0	COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
HFD2_k127_3803593_2	1121920.AUAU01000021_gene2510	2.438e-196	640.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_3803593_4	1380390.JIAT01000009_gene1303	1.299e-164	525.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CQZN@84995|Rubrobacteria	84995|Rubrobacteria	V	Domain of unknown function (DUF4162)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,DUF4162
HFD2_k127_3803593_12	1283299.AUKG01000001_gene1301	5.258e-125	409.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria,4CSFK@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HFD2_k127_3803593_43	1121866.AUGK01000006_gene956	5.974e-05	51.0	COG1028@1|root,COG1028@2|Bacteria,2GMWG@201174|Actinobacteria,4CUQ7@84998|Coriobacteriia	84998|Coriobacteriia	IQ	Short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_3803593_42	66269.NL54_07910	3.61e-06	53.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,3VZB7@53335|Pantoea	1236|Gammaproteobacteria	IQ	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate	gno	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HFD2_k127_3803593_5	1313172.YM304_26920	5.544e-164	548.0	COG0210@1|root,COG0514@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,2GISS@201174|Actinobacteria,4CMS6@84992|Acidimicrobiia	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_3803593_30	1386089.N865_20890	4.188e-51	197.0	2AD8S@1|root,312XT@2|Bacteria,2I87J@201174|Actinobacteria,4FK3I@85021|Intrasporangiaceae	201174|Actinobacteria	S	Golgi phosphoprotein 3 (GPP34)	-	-	-	-	-	-	-	-	-	-	-	-	GPP34
HFD2_k127_3803593_21	1313172.YM304_15580	7.089e-79	271.0	COG0637@1|root,COG0637@2|Bacteria,2HF8I@201174|Actinobacteria,4CNRE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_3803593_0	1313172.YM304_15570	9.057e-249	803.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
HFD2_k127_3803593_9	469383.Cwoe_2626	3.753e-136	444.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4CQB1@84995|Rubrobacteria	84995|Rubrobacteria	C	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD2_k127_3803593_29	404589.Anae109_4238	1.32e-51	188.0	COG2030@1|root,COG2030@2|Bacteria,1RJN8@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_3803593_24	1246448.ANAZ01000002_gene3799	6.038e-63	222.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_3803593_22	1246448.ANAZ01000002_gene3798	1.708e-70	247.0	2A651@1|root,30UXH@2|Bacteria,2IERM@201174|Actinobacteria	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_3803593_19	1089551.KE386572_gene4146	4.66e-85	289.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2U3GM@28211|Alphaproteobacteria,4BR7U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_3803593_10	452652.KSE_11740	9.685e-132	447.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,2M1P6@2063|Kitasatospora	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_3803593_37	1238425.J07HQW2_01956	2.038e-22	106.0	COG1296@1|root,arCOG04452@2157|Archaea,2XWP8@28890|Euryarchaeota,23VF2@183963|Halobacteria	183963|Halobacteria	E	branched-chain amino acid permease (azaleucine resistance)	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
HFD2_k127_3803593_6	710696.Intca_0369	6.9e-161	516.0	COG0596@1|root,COG1506@1|root,COG3710@1|root,COG0596@2|Bacteria,COG1506@2|Bacteria,COG3710@2|Bacteria,2HASC@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_3803593_28	443218.AS9A_4206	3.229e-56	207.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria,23FAN@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_3803593_40	589924.Ferp_1540	9.522e-12	69.0	COG4274@1|root,arCOG01119@2157|Archaea,2Y204@28890|Euryarchaeota,2477I@183980|Archaeoglobi	183980|Archaeoglobi	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_3803593_27	288000.BBta_5377	4.548e-59	214.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,3JV0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
HFD2_k127_3803593_3	298653.Franean1_4337	1.009e-192	629.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3803593_39	1068978.AMETH_2343	1.975e-12	67.0	COG1946@1|root,COG1946@2|Bacteria,2GMZB@201174|Actinobacteria,4E0QA@85010|Pseudonocardiales	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HFD2_k127_3810546_6	1380394.JADL01000001_gene2219	7.24e-47	177.0	COG2514@1|root,COG2514@2|Bacteria,1PNKQ@1224|Proteobacteria,2VAA8@28211|Alphaproteobacteria,2JY35@204441|Rhodospirillales	204441|Rhodospirillales	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_3810546_0	402881.Plav_1785	9.508e-176	563.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,1JQ3T@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
HFD2_k127_3810546_2	710111.FraQA3DRAFT_2529	1.552e-134	436.0	COG0346@1|root,COG0346@2|Bacteria,2GKY9@201174|Actinobacteria,4EWVQ@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	hpaD	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HFD2_k127_3810546_3	1121374.KB891589_gene82	6.038e-91	309.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	hydratase	hpaH	-	4.1.1.77	ko:K01617,ko:K02509	ko00350,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00350,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02602,R04132,R05374,R06897	RC00751,RC01615,RC02595,RC02672	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_4571,iYL1228.KPN_04784	FAA_hydrolase
HFD2_k127_3810546_7	1449976.KALB_2817	1.335e-45	168.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria,4E51C@85010|Pseudonocardiales	201174|Actinobacteria	P	TIGRFAM deazaflavin-dependent nitroreductase family protein	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD2_k127_3810546_4	1144343.PMI41_00629	4.443e-83	287.0	COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,43M67@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3810546_5	1172181.KB911698_gene5971	3.144e-77	268.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
HFD2_k127_3810546_9	338966.Ppro_0018	1.287e-44	172.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,43SF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_3810546_1	1120948.KB903240_gene4143	8.086e-166	541.0	COG3848@1|root,COG3848@2|Bacteria,2I3FP@201174|Actinobacteria,4E9TT@85010|Pseudonocardiales	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HFD2_k127_3810546_10	479433.Caci_2035	6.986e-28	128.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100,1.1.1.304,1.1.1.76	ko:K00059,ko:K18009	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_3810546_8	66875.JODY01000006_gene2209	1.735e-45	170.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_3818926_9	1237149.C900_01483	2.651e-05	53.0	COG2353@1|root,COG2353@2|Bacteria,4NQKY@976|Bacteroidetes,47RR5@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_3818926_7	1122247.C731_1622	1.388e-24	107.0	COG0298@1|root,COG0298@2|Bacteria,2IRJ9@201174|Actinobacteria,23ASW@1762|Mycobacteriaceae	201174|Actinobacteria	O	hydrogenase maturation factor	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HFD2_k127_3818926_0	1123024.AUII01000025_gene2098	1.231e-209	655.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DYZ6@85010|Pseudonocardiales	201174|Actinobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HFD2_k127_3818926_2	656024.FsymDg_2482	3.823e-111	367.0	COG0378@1|root,COG0378@2|Bacteria,2HP34@201174|Actinobacteria	201174|Actinobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HFD2_k127_3818926_4	497965.Cyan7822_3023	5.254e-47	180.0	2DBB1@1|root,2Z854@2|Bacteria,1G05N@1117|Cyanobacteria,3KHER@43988|Cyanothece	1117|Cyanobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
HFD2_k127_3818926_1	469383.Cwoe_5691	2.607e-146	486.0	COG3540@1|root,COG3540@2|Bacteria,2GNZ5@201174|Actinobacteria,4CRFP@84995|Rubrobacteria	84995|Rubrobacteria	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
HFD2_k127_3818926_6	1283283.ATXA01000014_gene3609	1.978e-29	129.0	COG0671@1|root,COG0671@2|Bacteria,2IAUJ@201174|Actinobacteria,4EW1N@85013|Frankiales	201174|Actinobacteria	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF2189,PAP2
HFD2_k127_3818926_8	1206744.BAGL01000068_gene5014	7.214e-17	91.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4G24K@85025|Nocardiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_3818926_3	1121946.AUAX01000010_gene3749	2.896e-57	211.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4DC6S@85008|Micromonosporales	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
HFD2_k127_3818926_5	1463909.KL585955_gene849	1.982e-36	144.0	COG0666@1|root,COG0666@2|Bacteria,2I9A2@201174|Actinobacteria	201174|Actinobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD2_k127_3889025_7	395019.Bmul_4271	7.881e-16	91.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VIZ1@28216|Betaproteobacteria,1KGZ0@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3889025_1	1313172.YM304_27710	9.211e-115	385.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CN3V@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HFD2_k127_3889025_2	1313172.YM304_27700	5.802e-114	372.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CMXE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HFD2_k127_3889025_3	1313172.YM304_27690	4.303e-70	249.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CNBV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD2_k127_3889025_0	1123023.JIAI01000002_gene4683	2.456e-118	390.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4E1C7@85010|Pseudonocardiales	201174|Actinobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HFD2_k127_3889025_5	557599.MKAN_11100	4.415e-47	177.0	COG2141@1|root,COG2141@2|Bacteria,2GSSV@201174|Actinobacteria,23D2X@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_3889025_4	1313172.YM304_27650	3.878e-65	229.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
HFD2_k127_3889025_6	1048339.KB913029_gene1389	2.009e-18	88.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4ETCS@85013|Frankiales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_3999368_8	1313172.YM304_38910	2.06e-37	144.0	2A58G@1|root,30TXM@2|Bacteria,2HG9Z@201174|Actinobacteria,4CN8R@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3999368_1	1313172.YM304_38920	1.047e-196	623.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4CMWU@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Adenylosuccinate lyase C-terminus	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD2_k127_3999368_4	1313172.YM304_38930	6.707e-175	571.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CMR5@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD2_k127_3999368_3	1313172.YM304_38960	5.809e-176	582.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CN2M@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HFD2_k127_3999368_5	479434.Sthe_1507	2.188e-92	316.0	COG0477@1|root,COG2814@2|Bacteria,2G8DX@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3999368_0	1313172.YM304_39000	0.0	1317.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CMTX@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_3999368_2	1120934.KB894424_gene1353	1.429e-188	630.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4DX3H@85010|Pseudonocardiales	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
HFD2_k127_3999368_11	570268.ANBB01000027_gene719	3.119e-11	73.0	COG4279@1|root,COG4279@2|Bacteria,2GIYW@201174|Actinobacteria,4EIXI@85012|Streptosporangiales	201174|Actinobacteria	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HFD2_k127_3999368_9	1380393.JHVP01000004_gene737	4.848e-32	136.0	2FDZX@1|root,34604@2|Bacteria,2IN56@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3999368_6	365528.KB891103_gene4058	2.57e-79	282.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERG0@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3999368_7	1144312.PMI09_00595	4.047e-74	261.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2VFR7@28211|Alphaproteobacteria,4BNBT@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_3999368_12	1172179.AUKV01000037_gene8269	1.975e-10	68.0	2B6UG@1|root,31ZTX@2|Bacteria,2H2R3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3999368_10	479435.Kfla_6369	2.78e-15	81.0	COG5485@1|root,COG5485@2|Bacteria,2IKXY@201174|Actinobacteria	201174|Actinobacteria	S	Ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HFD2_k127_3999368_13	1313172.YM304_41530	8.032e-07	55.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
HFD2_k127_4111053_4	479431.Namu_4196	4.454e-16	83.0	COG1835@1|root,COG1835@2|Bacteria,2GS8J@201174|Actinobacteria,4EV68@85013|Frankiales	201174|Actinobacteria	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_4111053_2	1313172.YM304_30570	3.688e-97	323.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,4CN4P@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4111053_1	1380387.JADM01000002_gene2023	2.746e-119	400.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,1XJKY@135619|Oceanospirillales	135619|Oceanospirillales	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_4111053_3	1313172.YM304_30550	2.297e-43	167.0	COG1848@1|root,COG1848@2|Bacteria,2H8GW@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HFD2_k127_4111053_5	1229780.BN381_210092	5.929e-13	78.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD2_k127_4111053_0	1313172.YM304_30530	1.147e-189	605.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNQV@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
HFD2_k127_4171645_2	981369.JQMJ01000001_gene6784	1.111e-53	190.0	arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria,2NIPM@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4171645_8	1179773.BN6_52000	8.849e-11	63.0	arCOG11411@1|root,33A8Q@2|Bacteria,2GRHE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4171645_7	1449347.JQLN01000001_gene219	1.941e-22	114.0	29VDB@1|root,30GU0@2|Bacteria,2HABQ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
HFD2_k127_4171645_6	1120934.KB894405_gene5271	2.526e-28	126.0	2CCBI@1|root,32RVA@2|Bacteria,2IFX8@201174|Actinobacteria	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HFD2_k127_4171645_5	1120934.KB894405_gene5272	4.849e-41	160.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD2_k127_4171645_1	345341.KUTG_07895	1.877e-172	567.0	COG3501@1|root,COG3501@2|Bacteria,2GP13@201174|Actinobacteria,4E10M@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
HFD2_k127_4171645_3	1120934.KB894405_gene5274	2.221e-49	181.0	COG3628@1|root,COG3628@2|Bacteria,2IFJ6@201174|Actinobacteria,4E3V5@85010|Pseudonocardiales	201174|Actinobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
HFD2_k127_4171645_0	1449347.JQLN01000001_gene225	1.563e-175	562.0	COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria,2M5AT@2063|Kitasatospora	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
HFD2_k127_4192326_25	1120949.KB903294_gene4481	7.969e-23	106.0	2B8DK@1|root,321NI@2|Bacteria,2H5SG@201174|Actinobacteria,4DMAY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4192326_17	1136417.AZWE01000087_gene3920	1.982e-59	211.0	COG1051@1|root,COG1051@2|Bacteria,2II3B@201174|Actinobacteria	201174|Actinobacteria	F	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_4192326_21	1123023.JIAI01000007_gene1824	6.366e-42	159.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5W6@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4192326_27	408672.NBCG_00887	4.293e-20	96.0	2BW4Y@1|root,346D2@2|Bacteria,2GTRH@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_4192326_20	1254432.SCE1572_23905	1.164e-48	176.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,43DXJ@68525|delta/epsilon subdivisions,2WZ51@28221|Deltaproteobacteria,2Z1CE@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4192326_15	1121877.JQKF01000007_gene981	1.483e-69	243.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Fatty acid desaturase	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_4192326_13	1313172.YM304_26220	6.604e-82	278.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD2_k127_4192326_0	1313172.YM304_26210	1.9e-322	1001.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia	201174|Actinobacteria	CJ	CoA binding domain	acdA1	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD2_k127_4192326_9	1313172.YM304_26190	1.548e-92	322.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD2_k127_4192326_19	1313172.YM304_26180	7.893e-58	211.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HFD2_k127_4192326_30	1313172.YM304_26170	5.347e-17	88.0	28R1E@1|root,2ZDG1@2|Bacteria,2HDQB@201174|Actinobacteria,4CNE2@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD2_k127_4192326_7	1313172.YM304_26120	1.144e-110	367.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4CN0Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
HFD2_k127_4192326_22	1313172.YM304_26100	3.817e-36	158.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4CN8X@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
HFD2_k127_4192326_1	1313172.YM304_26090	3.425e-300	927.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Proteasomal ATPase OB/ID domain	arc	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
HFD2_k127_4192326_28	1122939.ATUD01000003_gene3326	8.214e-20	103.0	COG1409@1|root,COG1409@2|Bacteria,2HKQQ@201174|Actinobacteria	201174|Actinobacteria	T	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006198,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0008199,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009405,GO:0009987,GO:0016043,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042301,GO:0042545,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0045229,GO:0046058,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0051704,GO:0055086,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
HFD2_k127_4192326_3	1313172.YM304_26070	2.416e-241	753.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4CMSZ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pup-ligase protein	dop	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HFD2_k127_4192326_29	1313172.YM304_26060	4.283e-19	88.0	2E9C2@1|root,333JS@2|Bacteria,2HGHP@201174|Actinobacteria,4CNEV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
HFD2_k127_4192326_6	1313172.YM304_26050	2.272e-117	385.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4CMX8@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HFD2_k127_4192326_8	1313172.YM304_26040	4.423e-97	325.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4CMY5@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HFD2_k127_4192326_12	390989.JOEG01000004_gene3770	4.338e-83	282.0	COG1540@1|root,COG1540@2|Bacteria,2GJA1@201174|Actinobacteria,4DAN5@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0271 (lamB) family	ycsF	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HFD2_k127_4192326_16	675635.Psed_6166	6.661e-60	220.0	COG2049@1|root,COG2049@2|Bacteria,2I2R8@201174|Actinobacteria,4E32G@85010|Pseudonocardiales	201174|Actinobacteria	E	Allophanate hydrolase subunit 1	kipI	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
HFD2_k127_4192326_14	1123251.ATWM01000003_gene1086	1.147e-72	262.0	COG1984@1|root,COG1984@2|Bacteria,2GITH@201174|Actinobacteria,4FGH8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Allophanate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B,CT_C_D
HFD2_k127_4192326_2	1313172.YM304_26020	7.803e-277	854.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HFD2_k127_4192326_18	1313172.YM304_26010	1.769e-58	211.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4CNAZ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Signal peptidase, peptidase S26	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD2_k127_4192326_10	1313172.YM304_26000	9.805e-84	284.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_4192326_24	1313172.YM304_25990	6.867e-24	106.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatB	GO:0003674,GO:0005215	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_4192326_11	1313172.YM304_25980	1.237e-83	287.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CN3F@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD2_k127_4192326_4	1229780.BN381_400030	3.132e-236	760.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,3UWB3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
HFD2_k127_4192326_23	1313172.YM304_25960	2.418e-34	140.0	COG1597@1|root,COG1597@2|Bacteria,2HCNI@201174|Actinobacteria	201174|Actinobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4192326_5	1229780.BN381_400028	2.96e-119	396.0	COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase, M20	amiB1	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_4192326_31	1313172.YM304_25950	2.451e-12	70.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
HFD2_k127_4243207_17	710686.Mycsm_00102	2.128e-40	151.0	COG1741@1|root,COG1741@2|Bacteria,2GJV3@201174|Actinobacteria,23325@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD2_k127_4243207_12	1123023.JIAI01000014_gene3814	5.647e-62	229.0	COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria,4E2WG@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_4243207_14	1380386.JIAW01000004_gene287	4.54e-55	209.0	COG2141@1|root,COG2141@2|Bacteria,2GNQ3@201174|Actinobacteria,23AJG@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_4243207_7	1313172.YM304_16100	1.79e-106	367.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HFD2_k127_4243207_11	1048339.KB913029_gene5063	4.328e-67	251.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4ETBP@85013|Frankiales	201174|Actinobacteria	S	subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_4243207_13	1944.JOAZ01000023_gene2556	1.408e-58	218.0	COG0842@1|root,COG0842@2|Bacteria,2I9MM@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HFD2_k127_4243207_10	1944.JOAZ01000023_gene2555	4.934e-81	278.0	COG1131@1|root,COG1131@2|Bacteria,2IE14@201174|Actinobacteria	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_4243207_1	1229780.BN381_250080	7.148e-200	640.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HFD2_k127_4243207_15	1313172.YM304_35160	1.799e-43	165.0	COG0344@1|root,COG0344@2|Bacteria,2IF8Y@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HFD2_k127_4243207_2	1313172.YM304_35130	1.773e-189	599.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CNN3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HFD2_k127_4243207_19	1313172.YM304_35120	1.53e-21	96.0	COG0535@1|root,COG0535@2|Bacteria,2GQQT@201174|Actinobacteria	201174|Actinobacteria	S	Mycofactocin system	mftB	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4243207_0	1313172.YM304_20540	1.794e-244	772.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4CMUM@84992|Acidimicrobiia	201174|Actinobacteria	L	AAA domain	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2
HFD2_k127_4243207_3	1313172.YM304_35030	1.028e-160	517.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CNIH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_4243207_5	1313172.YM304_34980	7.38e-119	389.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5,VWA_CoxE
HFD2_k127_4243207_8	1313172.YM304_34970	4.791e-98	330.0	COG2304@1|root,COG2304@2|Bacteria,2I959@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_CoxE
HFD2_k127_4243207_9	1313172.YM304_34960	1.624e-81	287.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HFD2_k127_4243207_18	1050202.KB913024_gene2432	9.051e-38	154.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,408BG@622450|Actinopolysporales	201174|Actinobacteria	M	Mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
HFD2_k127_4243207_4	452863.Achl_4588	6.602e-135	448.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,1WBPX@1268|Micrococcaceae	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_4243207_16	1313172.YM304_34950	1.676e-41	162.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria	201174|Actinobacteria	S	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD2_k127_4243207_6	208444.JNYY01000008_gene8611	1.158e-107	355.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4E0KX@85010|Pseudonocardiales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HFD2_k127_4246286_11	1229780.BN381_110063	2.069e-88	293.0	COG3000@1|root,COG3000@2|Bacteria,2GMF0@201174|Actinobacteria,3UXB6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_4246286_15	1041159.AZUW01000006_gene2016	4.136e-60	224.0	COG0665@1|root,COG0665@2|Bacteria,1R652@1224|Proteobacteria,2U1Q6@28211|Alphaproteobacteria,4BN2T@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_4246286_19	1499967.BAYZ01000171_gene5553	2.689e-30	136.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_4246286_14	331869.BAL199_05144	1.595e-66	234.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,4BPJE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	MA20_23640	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_4246286_6	1313172.YM304_10800	1.236e-114	393.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4246286_16	1313172.YM304_02890	5.905e-51	186.0	COG0640@1|root,COG0640@2|Bacteria,2HA3W@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_4246286_2	1313172.YM304_02880	3.223e-132	444.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4CNYN@84992|Acidimicrobiia	84992|Acidimicrobiia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_4246286_4	1123023.JIAI01000001_gene6612	4.494e-123	406.0	COG1960@1|root,COG1960@2|Bacteria,2IAYB@201174|Actinobacteria,4E0DQ@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HFD2_k127_4246286_9	1267535.KB906767_gene1817	2.533e-103	352.0	COG1995@1|root,COG1995@2|Bacteria,3Y37Q@57723|Acidobacteria	57723|Acidobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
HFD2_k127_4246286_20	1357275.AVEL02000120_gene4515	8.918e-23	113.0	COG3395@1|root,COG3395@2|Bacteria,1RF52@1224|Proteobacteria,1TF6B@1236|Gammaproteobacteria,1ZA7E@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HFD2_k127_4246286_17	1313172.YM304_20690	1.53e-47	189.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HFD2_k127_4246286_3	1038859.AXAU01000010_gene1869	4.168e-129	424.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria,3K3JE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4246286_0	1298863.AUEP01000008_gene1246	2.676e-245	787.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DTJJ@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_4246286_1	1298863.AUEP01000008_gene1247	2.149e-144	467.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,4DTFF@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
HFD2_k127_4246286_18	102125.Xen7305DRAFT_00005960	1.516e-33	139.0	COG0500@1|root,COG2226@2|Bacteria,1GQKV@1117|Cyanobacteria	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4246286_5	211114.JOEF01000001_gene7299	5.11e-115	378.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DYZJ@85010|Pseudonocardiales	201174|Actinobacteria	I	Dehydrogenase	fadB2	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_4246286_7	105420.BBPO01000020_gene5578	1.296e-110	367.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,2NFU0@228398|Streptacidiphilus	201174|Actinobacteria	E	TOBE domain	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HFD2_k127_4246286_10	285535.JOEY01000032_gene7978	2.273e-90	307.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate ABC transporter	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
HFD2_k127_4246286_13	1394178.AWOO02000041_gene8804	5.319e-67	237.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4EIMK@85012|Streptosporangiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_4246286_8	1122609.AUGT01000010_gene3758	1.889e-106	357.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4DNR3@85009|Propionibacteriales	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HFD2_k127_4246286_12	1313172.YM304_28210	1.147e-83	280.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CN3M@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F420-0:Gamma-glutamyl ligase	fbiB	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HFD2_k127_4349905_1	1313172.YM304_29070	1.277e-151	486.0	COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria,4CNEX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
HFD2_k127_4349905_5	1313172.YM304_30870	7.172e-103	341.0	COG1396@1|root,COG1396@2|Bacteria,2GJXM@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HFD2_k127_4349905_7	1205680.CAKO01000035_gene286	4.388e-09	64.0	arCOG10157@1|root,3220G@2|Bacteria,1N33N@1224|Proteobacteria,2UCKN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methylmuconolactone methyl-isomerase	-	-	-	-	-	-	-	-	-	-	-	-	MmlI
HFD2_k127_4349905_4	864051.BurJ1DRAFT_3964	4.198e-123	411.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_4349905_2	710111.FraQA3DRAFT_2529	3.963e-145	468.0	COG0346@1|root,COG0346@2|Bacteria,2GKY9@201174|Actinobacteria,4EWVQ@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	hpaD	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HFD2_k127_4349905_0	67373.JOBF01000023_gene6409	7.359e-216	697.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	hpaE	-	1.2.1.60	ko:K00151	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04418	RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_4349905_3	1157638.KB892162_gene2435	9.741e-142	458.0	COG0329@1|root,COG0329@2|Bacteria,2GNI3@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_4349905_6	330084.JNYZ01000027_gene8358	6.272e-30	123.0	COG1802@1|root,COG1802@2|Bacteria,2IBT4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_4373020_4	1313172.YM304_14250	2.721e-99	325.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CMYB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_4373020_5	1313172.YM304_14260	2.934e-93	321.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4CNWS@84992|Acidimicrobiia	84992|Acidimicrobiia	L	endonuclease III	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD2_k127_4373020_9	1123024.AUII01000006_gene4727	1.549e-13	73.0	2DS3D@1|root,33EC4@2|Bacteria,2GXNR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4373020_7	1313172.YM304_14670	3.038e-29	134.0	2E6FA@1|root,3312Q@2|Bacteria,2GUWJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4373020_0	1313172.YM304_14680	1.393e-199	633.0	COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria	201174|Actinobacteria	CO	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4373020_3	1313172.YM304_14700	2.26e-103	345.0	COG1235@1|root,COG1235@2|Bacteria,2IJCH@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_4373020_8	1313172.YM304_14710	6.257e-23	102.0	COG2259@1|root,COG2259@2|Bacteria,2ICCJ@201174|Actinobacteria	201174|Actinobacteria	O	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,MauE
HFD2_k127_4373020_1	1306174.JODP01000007_gene2522	7.022e-180	587.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase, S9A B C family, catalytic domain protein	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_4373020_6	1313172.YM304_14730	1.5e-30	126.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	fer	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HFD2_k127_4373020_2	525909.Afer_0543	3.929e-117	380.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD2_k127_4389823_34	1313172.YM304_42830	6.659e-52	190.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2HG9Y@201174|Actinobacteria,4CN8M@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Putative peptidoglycan binding domain	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	PG_binding_1
HFD2_k127_4389823_28	471852.Tcur_4977	1.427e-79	278.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4EG88@85012|Streptosporangiales	201174|Actinobacteria	K	ParB-like nuclease domain	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD2_k127_4389823_16	1313172.YM304_42850	5.35e-138	443.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD2_k127_4389823_48	1313172.YM304_42860	2.611e-19	94.0	COG0357@1|root,COG0357@2|Bacteria,2HGHA@201174|Actinobacteria,4CNEN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal RNA small subunit methyltransferase G	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD2_k127_4389823_29	1313172.YM304_42870	6.143e-74	257.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative single-stranded nucleic acids-binding domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
HFD2_k127_4389823_22	1313172.YM304_42880	2.043e-96	327.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CN42@84992|Acidimicrobiia	84992|Acidimicrobiia	U	60Kd inner membrane protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HFD2_k127_4389823_46	1313172.YM304_42890	8.026e-28	119.0	COG0759@1|root,COG0759@2|Bacteria,2HH1R@201174|Actinobacteria,4CP20@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HFD2_k127_4389823_52	298653.Franean1_7340	7.102e-07	58.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4ET9K@85013|Frankiales	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HFD2_k127_4389823_50	525909.Afer_2038	9.469e-11	72.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4CP4C@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L34	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HFD2_k127_4389823_6	1313172.YM304_00010	5.128e-185	589.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4CMQT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD2_k127_4389823_14	1313172.YM304_00020	7.808e-153	492.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CN18@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase III beta subunit	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD2_k127_4389823_15	1313172.YM304_00030	3.932e-143	462.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CN4M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HFD2_k127_4389823_47	1313172.YM304_00050	5.085e-21	96.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HFD2_k127_4389823_3	1229780.BN381_100171	3.634e-259	813.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,3UW89@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD2_k127_4389823_0	1380393.JHVP01000013_gene3377	0.0	1113.0	COG0188@1|root,COG1372@1|root,COG0188@2|Bacteria,COG1372@2|Bacteria,2GJ2Q@201174|Actinobacteria,4ERIW@85013|Frankiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
HFD2_k127_4389823_30	1313172.YM304_00110	3.617e-72	257.0	COG1748@1|root,COG1748@2|Bacteria,2H8X8@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4389823_23	1313172.YM304_00120	1.928e-87	297.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259,ko:K19311	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Hydrolase_4
HFD2_k127_4389823_38	1313172.YM304_00130	1.365e-41	162.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HFD2_k127_4389823_9	1313172.YM304_00140	8.751e-176	561.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4CN6N@84992|Acidimicrobiia	84992|Acidimicrobiia	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
HFD2_k127_4389823_2	1313172.YM304_00150	3.266e-300	934.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_4389823_20	745776.DGo_CA2403	1.079e-99	351.0	COG1167@1|root,COG1167@2|Bacteria,1WI0K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EK	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD2_k127_4389823_10	1415166.NONO_c61450	7.8e-173	561.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4FUZR@85025|Nocardiaceae	201174|Actinobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_4389823_12	1429916.X566_07685	7.185e-166	531.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria,3JRJ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	MA20_23445	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
HFD2_k127_4389823_41	414684.RC1_1051	3.271e-38	153.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria,2JSRI@204441|Rhodospirillales	204441|Rhodospirillales	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	-	-	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_4389823_51	1144343.PMI41_04686	7.53e-10	70.0	COG3021@1|root,COG3021@2|Bacteria,1MYEQ@1224|Proteobacteria,2UAZC@28211|Alphaproteobacteria,43HY1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_4389823_37	1352941.M877_01585	6.446e-43	171.0	COG2867@1|root,COG2867@2|Bacteria,2IGNZ@201174|Actinobacteria	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_4389823_35	365528.KB891103_gene4180	1.762e-50	193.0	COG1309@1|root,COG1309@2|Bacteria,2I9F9@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_4389823_25	1410620.SHLA_23c000470	8.502e-85	304.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TT0P@28211|Alphaproteobacteria,4B7IA@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_4389823_32	1313172.YM304_01160	2.083e-71	251.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4CNUS@84992|Acidimicrobiia	84992|Acidimicrobiia	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
HFD2_k127_4389823_33	404589.Anae109_1653	8.851e-59	213.0	COG3145@1|root,COG3145@2|Bacteria,1PI8D@1224|Proteobacteria,435FJ@68525|delta/epsilon subdivisions,2WZT5@28221|Deltaproteobacteria,2Z2PP@29|Myxococcales	28221|Deltaproteobacteria	L	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
HFD2_k127_4389823_26	1156937.MFUM_270003	2.495e-83	291.0	COG0161@1|root,COG0161@2|Bacteria,46Z8A@74201|Verrucomicrobia,37GKM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HFD2_k127_4389823_19	1121926.AXWO01000002_gene1484	5.205e-107	372.0	COG0657@1|root,COG0657@2|Bacteria,2IDTS@201174|Actinobacteria	201174|Actinobacteria	I	Pectinacetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	PAE
HFD2_k127_4389823_40	1463936.JOJI01000031_gene2185	5.151e-39	150.0	2E2XX@1|root,32XYT@2|Bacteria,2IK9M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4389823_17	1313172.YM304_02000	7.139e-132	432.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4CN2E@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Reductase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C
HFD2_k127_4389823_1	1313172.YM304_02010	7.4e-322	1007.0	COG0466@1|root,COG0466@2|Bacteria,2HH29@201174|Actinobacteria,4CP2C@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATPase family associated with various cellular activities (AAA)	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA
HFD2_k127_4389823_11	1048339.KB913029_gene3544	5.797e-169	539.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4ERVR@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_4389823_43	1313172.YM304_02030	1.333e-32	131.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K18996	-	-	-	-	ko00000,ko03032	-	-	-	MarR,RP-C,RP-C_C
HFD2_k127_4389823_4	1229780.BN381_70027	1.931e-191	621.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,3UX6T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HFD2_k127_4389823_7	1313172.YM304_02040	7.349e-180	572.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_4389823_44	1313172.YM304_02050	1.035e-31	128.0	28YVQ@1|root,2ZKNY@2|Bacteria,2HCMJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4389823_24	1313172.YM304_02070	3.075e-85	288.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,4CN3U@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Peptidase C26	-	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD2_k127_4389823_5	1313172.YM304_02120	1.381e-187	614.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CMUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HFD2_k127_4389823_13	1313172.YM304_02130	3.952e-165	534.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4CMY4@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin binding protein transpeptidase domain	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HFD2_k127_4389823_8	1313172.YM304_02140	7.652e-180	593.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CMWK@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_4389823_31	1313172.YM304_02150	9.689e-72	257.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CN1S@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD2_k127_4389823_39	1313172.YM304_02160	2.5e-40	159.0	COG1716@1|root,COG1716@2|Bacteria,2HGEP@201174|Actinobacteria,4CNCQ@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HFD2_k127_4389823_27	1313172.YM304_02170	1.63e-82	280.0	COG1716@1|root,COG1716@2|Bacteria,2HG8X@201174|Actinobacteria,4CN6T@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
HFD2_k127_4389823_54	1429916.X566_17870	1.27e-05	51.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_4389823_42	102129.Lepto7375DRAFT_8109	2.874e-36	147.0	COG2162@1|root,COG2162@2|Bacteria,1G6IN@1117|Cyanobacteria,1HHR2@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
HFD2_k127_4389823_18	1121377.KB906436_gene921	3.094e-130	447.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_4389823_21	1463856.JOHY01000038_gene1570	2.085e-99	336.0	COG2706@1|root,COG2706@2|Bacteria,2I6SW@201174|Actinobacteria	201174|Actinobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_4390701_4	1121385.AQXW01000001_gene792	2.236e-05	57.0	28HEJ@1|root,3468D@2|Bacteria,2HH12@201174|Actinobacteria,1ZX1S@145357|Dermacoccaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4390701_2	1313172.YM304_29760	1.472e-36	158.0	COG2385@1|root,COG2755@1|root,COG3409@1|root,COG2385@2|Bacteria,COG2755@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.4.17.14	ko:K07260,ko:K21449	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02000	1.B.40.2	-	-	Amidase_3,CHAP,ChW,PG_binding_1,SpoIID,VanY
HFD2_k127_4390701_0	525909.Afer_0052	3.56e-74	253.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4CMXC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
HFD2_k127_4390701_1	1304865.JAGF01000001_gene2934	1.246e-64	253.0	2EZYF@1|root,33T2N@2|Bacteria,2H3P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4437463_9	1121440.AUMA01000006_gene1673	2.208e-34	136.0	COG3818@1|root,COG3818@2|Bacteria,1RG7T@1224|Proteobacteria	1224|Proteobacteria	S	Acetyltransferase, GNAT	-	-	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
HFD2_k127_4437463_7	91464.S7335_311	2.194e-45	168.0	COG0251@1|root,COG0251@2|Bacteria,1GH5A@1117|Cyanobacteria,1H39X@1129|Synechococcus	1117|Cyanobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_4437463_8	1313172.YM304_26530	4.317e-40	158.0	2DPBC@1|root,331CT@2|Bacteria,2GS2F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4437463_5	1313172.YM304_26520	9.41e-75	265.0	COG1090@1|root,COG1090@2|Bacteria,2I3Q5@201174|Actinobacteria	201174|Actinobacteria	S	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HFD2_k127_4437463_1	211114.JOEF01000003_gene3183	1.475e-128	418.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4E3AB@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_4437463_3	285535.JOEY01000034_gene9894	7.253e-97	344.0	COG0596@1|root,COG0654@1|root,COG0596@2|Bacteria,COG0654@2|Bacteria,2GJDM@201174|Actinobacteria	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_4437463_0	285535.JOEY01000034_gene9894	9.953e-142	464.0	COG0596@1|root,COG0654@1|root,COG0596@2|Bacteria,COG0654@2|Bacteria,2GJDM@201174|Actinobacteria	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_4437463_6	1235457.C404_23465	2.019e-67	249.0	COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VQ6P@28216|Betaproteobacteria,1K2NS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pyridoxamine 5'-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_4437463_10	67373.JOBF01000024_gene6810	1.208e-05	48.0	COG2764@1|root,COG2764@2|Bacteria,2I4Q8@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4437463_2	1313172.YM304_02550	2.637e-111	371.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria	201174|Actinobacteria	E	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_4437463_4	1211815.CBYP010000056_gene3346	9.995e-89	296.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4ERS8@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	dapC	-	2.6.1.1,2.6.1.17	ko:K00812,ko:K10907,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_4440906_19	1122612.AUBA01000006_gene2349	7.45e-06	54.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K2R1@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_4440906_5	479432.Sros_8740	8.148e-42	161.0	COG1309@1|root,COG1309@2|Bacteria,2IQGF@201174|Actinobacteria,4EQAF@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_4440906_1	2002.JOEQ01000022_gene6956	4.948e-240	764.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EHPN@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_4440906_2	1122138.AQUZ01000005_gene2614	5.02e-235	760.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DN2U@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_4440906_10	1313172.YM304_34610	3.101e-22	98.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_4440906_3	1313172.YM304_18940	8.698e-112	370.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,4CNUE@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_4440906_0	1313172.YM304_18950	2.47e-250	793.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HFD2_k127_4440906_8	1313172.YM304_18960	1.753e-26	117.0	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
HFD2_k127_4440906_6	1313172.YM304_18970	4.01e-38	149.0	2C2HI@1|root,345RC@2|Bacteria,2H8AE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4440906_4	1313172.YM304_18980	2.126e-46	173.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12	ko:K02226,ko:K15634,ko:K22305,ko:K22306,ko:K22316	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
HFD2_k127_4440906_15	1394178.AWOO02000011_gene4020	5.213e-14	76.0	COG1366@1|root,COG1366@2|Bacteria,2IHP9@201174|Actinobacteria,4EK6E@85012|Streptosporangiales	201174|Actinobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HFD2_k127_4440906_20	1907.SGLAU_25870	0.0004003	48.0	COG1366@1|root,COG1366@2|Bacteria,2GUNY@201174|Actinobacteria	201174|Actinobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS_2
HFD2_k127_4440906_13	1304865.JAGF01000001_gene613	3.462e-17	93.0	COG0681@1|root,COG0681@2|Bacteria,2GX48@201174|Actinobacteria	201174|Actinobacteria	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD2_k127_4440906_16	1033730.CAHG01000016_gene461	1.193e-12	73.0	2BBSN@1|root,325AU@2|Bacteria,2HAF6@201174|Actinobacteria,4DW9U@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4440906_9	1163408.UU9_00909	9.633e-25	104.0	2EC7F@1|root,33660@2|Bacteria,1N839@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4440906_12	1304865.JAGF01000001_gene2956	2.593e-18	88.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4F2MZ@85016|Cellulomonadaceae	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HFD2_k127_4440906_18	272624.lpg1742	7.623e-08	61.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4440906_17	1121100.JCM6294_3193	2.746e-08	56.0	COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,2G32Z@200643|Bacteroidia,4AW8T@815|Bacteroidaceae	976|Bacteroidetes	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD2_k127_4454758_16	1313172.YM304_27490	1.476e-68	239.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4CMWX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S2	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD2_k127_4454758_10	1313172.YM304_27480	7.962e-104	348.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4CMXN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HFD2_k127_4454758_8	1313172.YM304_27470	1.518e-112	370.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CMRF@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD2_k127_4454758_15	1313172.YM304_27460	1.332e-73	262.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4CN2Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD2_k127_4454758_6	1313172.YM304_27450	5.703e-122	407.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD2_k127_4454758_4	1313172.YM304_27440	1.344e-159	511.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CMRC@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD2_k127_4454758_7	1313172.YM304_27430	1.848e-116	389.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CMZX@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD2_k127_4454758_3	1313172.YM304_27420	4.038e-209	655.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HFD2_k127_4454758_17	1211815.CBYP010000040_gene2553	7.408e-60	220.0	COG2820@1|root,COG2820@2|Bacteria,2IT3V@201174|Actinobacteria	201174|Actinobacteria	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
HFD2_k127_4454758_14	1313172.YM304_27410	2.431e-79	276.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HFD2_k127_4454758_1	1229780.BN381_100080	5.178e-246	764.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_4454758_13	1229780.BN381_10284	5.257e-87	306.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,3UWH6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
HFD2_k127_4454758_18	644968.DFW101_0461	4.067e-54	201.0	COG0500@1|root,COG2226@2|Bacteria,1QXB6@1224|Proteobacteria,42XMA@68525|delta/epsilon subdivisions,2WSKF@28221|Deltaproteobacteria,2M9F9@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_4454758_2	1313172.YM304_27360	2.995e-239	752.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMUC@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HFD2_k127_4454758_5	1123320.KB889697_gene9013	1.151e-134	444.0	COG0477@1|root,COG2814@2|Bacteria,2GIZX@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_4454758_12	1110697.NCAST_23_00160	1.365e-91	318.0	2C56P@1|root,2ZJ2W@2|Bacteria,2IKDI@201174|Actinobacteria,4G0AJ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4454758_11	1313172.YM304_27260	3e-96	321.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria	201174|Actinobacteria	P	inositol monophosphatase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HFD2_k127_4454758_0	1313172.YM304_27180	1.028e-301	932.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4CNI9@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD2_k127_4454758_19	243233.MCA2966	2.39e-40	161.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD2_k127_4454758_20	67257.JODR01000018_gene4275	6.591e-06	53.0	COG3291@1|root,COG3386@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,2GNGF@201174|Actinobacteria	201174|Actinobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Copper-bind,DUF1080
HFD2_k127_4454758_9	1313172.YM304_23290	1.382e-108	361.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CMWS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HFD2_k127_4461499_5	1394178.AWOO02000071_gene376	4.572e-67	234.0	COG0488@1|root,COG0488@2|Bacteria,2GMUD@201174|Actinobacteria,4EG06@85012|Streptosporangiales	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_4461499_0	1313172.YM304_03440	5.21e-150	484.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,4CP59@84992|Acidimicrobiia	201174|Actinobacteria	J	Protein synonym peptidase M	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD2_k127_4461499_2	1313172.YM304_24940	1.594e-89	313.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria	201174|Actinobacteria	V	MATE efflux family protein	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
HFD2_k127_4461499_3	1313172.YM304_03420	1.157e-88	310.0	COG0827@1|root,COG0827@2|Bacteria,2HGZ7@201174|Actinobacteria,4CNZE@84992|Acidimicrobiia	84992|Acidimicrobiia	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HFD2_k127_4461499_1	1313172.YM304_03410	1.483e-141	455.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria	201174|Actinobacteria	H	(Pantothenic acid kinase))	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HFD2_k127_4461499_4	1313172.YM304_03330	4.586e-77	265.0	COG1011@1|root,COG1011@2|Bacteria,2GN3E@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD2_k127_4461499_6	1313172.YM304_03320	5.407e-45	166.0	COG2964@1|root,COG2964@2|Bacteria,2IHSD@201174|Actinobacteria	201174|Actinobacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22
HFD2_k127_4503409_6	1313172.YM304_25450	1.066e-118	389.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CN09@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_4503409_11	1449346.JQMO01000002_gene749	4.131e-81	286.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,2M40U@2063|Kitasatospora	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_4503409_3	471852.Tcur_0327	4.022e-164	541.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EHQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HFD2_k127_4503409_22	886293.Sinac_3314	1.702e-46	180.0	COG0673@1|root,COG0673@2|Bacteria,2IZC8@203682|Planctomycetes	203682|Planctomycetes	C	and related	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD2_k127_4503409_0	1313172.YM304_25470	1.008e-255	800.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4CP51@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4503409_26	2074.JNYD01000009_gene5188	1.32e-28	130.0	COG2912@1|root,COG2912@2|Bacteria,2GMER@201174|Actinobacteria,4EARR@85010|Pseudonocardiales	201174|Actinobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HFD2_k127_4503409_13	1313172.YM304_25490	6.491e-77	262.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD2_k127_4503409_2	1313172.YM304_25510	1.095e-204	642.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_4503409_24	1380347.JNII01000005_gene3377	1.605e-30	124.0	COG1276@1|root,COG1276@2|Bacteria	2|Bacteria	P	copper resistance	ycnJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopC,CopD,Cytochrome_CBB3,YtkA
HFD2_k127_4503409_5	1313172.YM304_25520	1.512e-152	494.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia	84992|Acidimicrobiia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD2_k127_4503409_1	1313172.YM304_25530	1.835e-213	673.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CMW9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HFD2_k127_4503409_4	1229780.BN381_40072	2.501e-160	526.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,3UWEY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
HFD2_k127_4503409_17	1121877.JQKF01000029_gene2105	4.838e-60	224.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria,4CNQ0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_4503409_10	1121877.JQKF01000012_gene330	4.101e-82	279.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_4503409_16	1121877.JQKF01000012_gene331	1.9e-63	231.0	28KBH@1|root,2Z9YH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4503409_9	1240349.ANGC01000066_gene88	1.9e-82	275.0	COG1839@1|root,COG1839@2|Bacteria,2IAR3@201174|Actinobacteria,4FYWC@85025|Nocardiaceae	201174|Actinobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HFD2_k127_4503409_7	1304865.JAGF01000001_gene95	2.929e-99	349.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HFD2_k127_4503409_25	159087.Daro_3975	4.444e-29	132.0	COG2199@1|root,COG3614@1|root,COG2199@2|Bacteria,COG3614@2|Bacteria,1RGCV@1224|Proteobacteria,2WGZP@28216|Betaproteobacteria,2KVQG@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GGDEF,PAS_3
HFD2_k127_4503409_20	1242864.D187_000281	1.658e-52	203.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,42WQU@68525|delta/epsilon subdivisions,2WTEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HFD2_k127_4503409_32	1283299.AUKG01000001_gene2158	4.899e-05	56.0	2B8TX@1|root,32240@2|Bacteria,2HRST@201174|Actinobacteria,4CTW1@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4503409_29	383372.Rcas_3310	9.336e-10	72.0	2ET4Z@1|root,33KP2@2|Bacteria,2G97T@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4503409_12	1313172.YM304_06270	5.412e-79	286.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_4503409_14	1128421.JAGA01000002_gene314	1.983e-75	266.0	COG1131@1|root,COG1131@2|Bacteria,2NQPB@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_4503409_18	1313172.YM304_06730	2.144e-59	235.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA,VWA_2
HFD2_k127_4503409_31	570268.ANBB01000056_gene47	1.508e-06	61.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4ER1E@85012|Streptosporangiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_4503409_8	1313172.YM304_25660	3.396e-90	302.0	COG2135@1|root,COG2135@2|Bacteria,2HGDR@201174|Actinobacteria,4CNC9@84992|Acidimicrobiia	84992|Acidimicrobiia	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HFD2_k127_4503409_19	1313172.YM304_25670	5.335e-55	196.0	COG0537@1|root,COG0537@2|Bacteria,2IKWU@201174|Actinobacteria	201174|Actinobacteria	FG	Histidine triad (Hit) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HFD2_k127_4503409_15	1313172.YM304_25680	7.062e-66	235.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4CN98@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_4503409_23	1229780.BN381_40082	1.018e-33	136.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,3UWSM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
HFD2_k127_4534309_17	864702.OsccyDRAFT_1879	2.743e-107	359.0	COG0438@1|root,COG0438@2|Bacteria,1G0TD@1117|Cyanobacteria,1H8K5@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K03867	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_4534309_32	1313172.YM304_08800	3.759e-62	220.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4CN26@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD2_k127_4534309_37	1313172.YM304_08810	1.555e-45	175.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4CN72@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HFD2_k127_4534309_15	1313172.YM304_08820	1.749e-118	396.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4CMWY@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_4534309_0	1313172.YM304_08840	0.0	1389.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4CN8H@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glutamine amidotransferase domain	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HFD2_k127_4534309_39	1313172.YM304_08850	2.936e-43	169.0	COG0736@1|root,COG0736@2|Bacteria,2HGFC@201174|Actinobacteria,4CND0@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD2_k127_4534309_9	1313172.YM304_08910	1.472e-145	474.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4CMZ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_4534309_16	1313172.YM304_08920	7.416e-114	384.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CN11@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_4534309_42	1410632.JHWW01000020_gene361	4.705e-24	109.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,27MWC@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD2_k127_4534309_20	1313172.YM304_08940	1.623e-94	317.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_4534309_34	1313172.YM304_08950	3.234e-54	198.0	COG0454@1|root,COG0456@2|Bacteria,2HGCA@201174|Actinobacteria,4CNAC@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HFD2_k127_4534309_7	1313172.YM304_08960	8.058e-158	510.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4CMUH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_4534309_8	1313172.YM304_08980	1.043e-157	505.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
HFD2_k127_4534309_38	1318628.MARLIPOL_01550	1.356e-43	175.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,467B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG0424 Nucleotide-binding protein implicated in inhibition of septum formation	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD2_k127_4534309_40	446468.Ndas_4026	1.558e-39	149.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4EJRJ@85012|Streptosporangiales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD2_k127_4534309_1	1313172.YM304_35380	2.872e-273	848.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CMU0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD2_k127_4534309_35	1313172.YM304_35360	9.861e-49	182.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_4534309_43	61459.XP_007783934.1	4.295e-19	93.0	2E1C8@1|root,2S8PP@2759|Eukaryota,3A7JI@33154|Opisthokonta,3P3QQ@4751|Fungi,3QX9Q@4890|Ascomycota,20I7G@147545|Eurotiomycetes,3MTMZ@451870|Chaetothyriomycetidae	4751|Fungi	S	Prokaryotic phospholipase A2	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_A2_3
HFD2_k127_4534309_5	1313172.YM304_35320	3.519e-211	664.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4CN9X@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD2_k127_4534309_2	1313172.YM304_35250	1.662e-241	755.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4CMTF@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HFD2_k127_4534309_30	1313172.YM304_35230	1.242e-73	262.0	COG0791@1|root,COG1196@1|root,COG0791@2|Bacteria,COG1196@2|Bacteria,2GIWB@201174|Actinobacteria,4CNAP@84992|Acidimicrobiia	84992|Acidimicrobiia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SLT
HFD2_k127_4534309_12	1313172.YM304_35210	1.665e-132	430.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4CNSV@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_4534309_44	164757.Mjls_0631	4.168e-09	67.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,233FA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
HFD2_k127_4534309_3	1313172.YM304_35190	1.278e-232	732.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4534309_36	330084.JNYZ01000019_gene4480	8.402e-47	178.0	COG0726@1|root,COG0726@2|Bacteria,2IFJ1@201174|Actinobacteria	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD2_k127_4534309_10	378806.STAUR_6873	6.007e-138	445.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42UHA@68525|delta/epsilon subdivisions,2WQA0@28221|Deltaproteobacteria,2YUHZ@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HFD2_k127_4534309_27	591158.SSMG_04799	5.752e-78	287.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria	201174|Actinobacteria	M	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_4534309_24	471857.Svir_13060	3.045e-83	286.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4DZJ6@85010|Pseudonocardiales	201174|Actinobacteria	K	TIGRFAM beta-ketoadipate pathway transcriptional regulators, PcaR PcaU PobR family	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_4534309_11	1268068.PG5_47190	4.702e-136	443.0	28IZD@1|root,2Z8WU@2|Bacteria,1NEGQ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4534309_13	28042.GU90_13435	8.353e-132	424.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4DXHC@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	gctA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_4534309_19	1125971.ASJB01000009_gene911	5.244e-95	317.0	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4DXIJ@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl CoA acetate 3-ketoacid CoA	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_4534309_18	675635.Psed_4439	4.824e-107	361.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HFD2_k127_4534309_6	1089546.AQUI01000002_gene2218	4.328e-163	524.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,407V4@622450|Actinopolysporales	201174|Actinobacteria	I	Thiolase, C-terminal domain	pcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_4534309_4	1121946.AUAX01000026_gene6325	7.094e-220	699.0	COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria,4D8NB@85008|Micromonosporales	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_4534309_21	189753.AXAS01000001_gene3639	3.726e-93	319.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2TTF6@28211|Alphaproteobacteria,3JV1J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HFD2_k127_4534309_26	857087.Metme_4597	1.785e-78	285.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1XDVA@135618|Methylococcales	135618|Methylococcales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_4534309_23	1108045.GORHZ_245_00240	2.332e-90	309.0	COG0346@1|root,COG0346@2|Bacteria,2GN2E@201174|Actinobacteria,4GCD2@85026|Gordoniaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4534309_31	1123023.JIAI01000019_gene2174	2.483e-67	242.0	COG1802@1|root,COG1802@2|Bacteria,2HSE5@201174|Actinobacteria,4E0Y9@85010|Pseudonocardiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_4534309_14	1157708.KB907457_gene2607	1.163e-130	434.0	COG0683@1|root,COG0683@2|Bacteria,1N0MT@1224|Proteobacteria	1224|Proteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6,TAT_signal
HFD2_k127_4534309_29	388051.AUFE01000043_gene3314	1.048e-73	261.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2VZHK@28216|Betaproteobacteria,1K943@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_4534309_25	408672.NBCG_00687	5.337e-80	282.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DUR7@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_4534309_22	1123060.JONP01000011_gene3074	1.17e-92	317.0	COG0559@1|root,COG0559@2|Bacteria,1QDNH@1224|Proteobacteria,2U1CJ@28211|Alphaproteobacteria,2JTED@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HFD2_k127_4534309_28	384765.SIAM614_29071	2.989e-75	276.0	COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2TTSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_4534309_33	1299327.I546_1353	2.162e-57	204.0	COG1741@1|root,COG1741@2|Bacteria,2GJV3@201174|Actinobacteria,23325@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD2_k127_4565174_27	1313172.YM304_19960	2.327e-07	52.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_4565174_21	1120950.KB892709_gene4152	3.445e-20	100.0	COG0642@1|root,COG2205@2|Bacteria,2I8QG@201174|Actinobacteria,4DR6H@85009|Propionibacteriales	201174|Actinobacteria	T	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118
HFD2_k127_4565174_28	350058.Mvan_4758	0.0004424	45.0	29VUW@1|root,30HCN@2|Bacteria,2GY1N@201174|Actinobacteria,23C4C@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Potass_KdpF
HFD2_k127_4565174_3	419947.MRA_1037	1.108e-253	793.0	COG2060@1|root,COG2060@2|Bacteria,2GK51@201174|Actinobacteria,232MD@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HFD2_k127_4565174_0	419947.MRA_1038	6.406e-306	960.0	COG2216@1|root,COG2216@2|Bacteria,2GIWT@201174|Actinobacteria,234VJ@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HFD2_k127_4565174_16	419947.MRA_1039	2.504e-50	194.0	COG2156@1|root,COG2156@2|Bacteria,2GK75@201174|Actinobacteria,232GY@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HFD2_k127_4565174_18	570268.ANBB01000047_gene3992	1.429e-36	148.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria,4EG5A@85012|Streptosporangiales	201174|Actinobacteria	T	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_4565174_4	1120950.KB892766_gene5082	1.384e-240	769.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,4DP0I@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	kdpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HFD2_k127_4565174_12	1229780.BN381_130212	3.491e-83	285.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,3UWH9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_4565174_26	1150864.MILUP08_44120	6.31e-10	64.0	COG1366@1|root,COG1366@2|Bacteria,2GQBG@201174|Actinobacteria,4DFF7@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HFD2_k127_4565174_20	525904.Tter_0198	4.415e-30	124.0	COG2323@1|root,COG2323@2|Bacteria,2NS3E@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HFD2_k127_4565174_24	1283287.KB822579_gene1908	3.619e-14	83.0	2BJJG@1|root,32DWK@2|Bacteria,2INK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4565174_7	1313172.YM304_19970	9.987e-191	605.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4CNBR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
HFD2_k127_4565174_2	1313172.YM304_19980	3.848e-254	822.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CMU8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD2_k127_4565174_23	298655.KI912267_gene7476	1.513e-14	84.0	COG5340@1|root,COG5340@2|Bacteria,2I56S@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4,DUF559
HFD2_k127_4565174_17	1313172.YM304_26420	7.157e-49	178.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HFD2_k127_4565174_5	1313172.YM304_26410	3.02e-208	655.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CMYY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
HFD2_k127_4565174_6	1313172.YM304_26380	1.252e-200	634.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CMS1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_4565174_11	1313172.YM304_26370	4.923e-90	323.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4CNDA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
HFD2_k127_4565174_14	1313172.YM304_26360	2.81e-77	269.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_4565174_13	1313172.YM304_26340	6.635e-83	284.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	-	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_4565174_9	1313172.YM304_26330	4.51e-151	486.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4CN2B@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
HFD2_k127_4565174_10	1313172.YM304_26310	4.445e-121	419.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4CMXM@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD2_k127_4565174_8	1313172.YM304_26290	2.432e-151	494.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4CN0N@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_4565174_1	1313172.YM304_26280	2.124e-276	870.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4CNKC@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_4579056_18	446471.Xcel_0066	0.0001701	52.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,4F4ZK@85017|Promicromonosporaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4579056_14	351607.Acel_0571	3.136e-49	189.0	COG1028@1|root,COG1028@2|Bacteria,2GQBK@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_4579056_11	1123024.AUII01000008_gene1866	6.873e-57	209.0	COG1414@1|root,COG1414@2|Bacteria,2GMEA@201174|Actinobacteria,4E5K1@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_4579056_2	649638.Trad_1888	2.392e-215	678.0	COG2368@1|root,COG2368@2|Bacteria,1WJ7C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	4-hydroxyphenylacetate 3-monooxygenase oxygenase	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
HFD2_k127_4579056_0	1123320.KB889566_gene5764	7.814e-307	980.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria	201174|Actinobacteria	C	indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179,ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR,POR_N,TPP_enzyme_C
HFD2_k127_4579056_1	28042.GU90_16820	3.215e-223	720.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_4579056_6	290400.Jann_4161	6.125e-155	500.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	4-hydroxybenzoate	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD2_k127_4579056_17	1492922.GY26_07100	7.473e-34	138.0	COG0599@1|root,COG2267@1|root,COG0599@2|Bacteria,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,1RYSX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	3-oxoadipate enol-lactonase	-	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1380	Abhydrolase_1,Abhydrolase_6,CMD
HFD2_k127_4579056_8	33876.JNXY01000020_gene4367	1.392e-76	268.0	COG3485@1|root,COG3485@2|Bacteria,2GMGM@201174|Actinobacteria,4D92V@85008|Micromonosporales	201174|Actinobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
HFD2_k127_4579056_13	1380355.JNIJ01000044_gene5535	6.055e-51	194.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2TTZJ@28211|Alphaproteobacteria,3JSK1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HFD2_k127_4579056_16	479434.Sthe_0607	3.091e-44	174.0	COG0015@1|root,COG0015@2|Bacteria,2G607@200795|Chloroflexi,27XJC@189775|Thermomicrobia	200795|Chloroflexi	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
HFD2_k127_4579056_9	1313172.YM304_16380	2.48e-63	225.0	2B34Q@1|root,31VSF@2|Bacteria,2I9DC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4579056_4	760192.Halhy_0465	1.76e-167	533.0	COG0620@1|root,COG0620@2|Bacteria,4NJAH@976|Bacteroidetes,1IZXY@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0620 Methionine synthase II (cobalamin-independent)	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_4579056_7	1313172.YM304_27120	3.979e-115	377.0	COG0667@1|root,COG0667@2|Bacteria,2ICY2@201174|Actinobacteria,4CNT7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_4579056_5	525909.Afer_1367	1.612e-158	514.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CMUG@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Protein synonym acyl-CoA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4579056_12	1229780.BN381_430004	7.19e-57	205.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,3UWS8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
HFD2_k127_4579056_15	1229780.BN381_70068	1.815e-48	195.0	COG3850@1|root,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K03406,ko:K07673,ko:K07675	ko02020,ko02030,map02020,map02030	M00471,M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
HFD2_k127_4579056_10	1229780.BN381_430006	2.844e-63	224.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,3UWZH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_4579056_3	1313172.YM304_21410	2.529e-207	650.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CMW4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S1-like RNA-binding domain	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_4583550_8	177439.DP0632	9.348e-77	273.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MHYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HFD2_k127_4583550_7	338966.Ppro_2829	1.772e-85	292.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,43U7N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HFD2_k127_4583550_12	1237500.ANBA01000014_gene5588	9.703e-17	86.0	COG5592@1|root,COG5592@2|Bacteria,2HF5Y@201174|Actinobacteria,4EJFU@85012|Streptosporangiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_4583550_10	526225.Gobs_0489	5.986e-35	148.0	COG2199@1|root,COG3706@2|Bacteria,2I8IE@201174|Actinobacteria	201174|Actinobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_4583550_3	497965.Cyan7822_4183	2.385e-127	440.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KG2U@43988|Cyanothece	1117|Cyanobacteria	T	Response regulator receiver modulated diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_4583550_2	216594.MMAR_3522	1.038e-127	449.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,Guanylate_cyc,NB-ARC
HFD2_k127_4583550_0	1123024.AUII01000010_gene684	2.363e-189	602.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4E2F7@85010|Pseudonocardiales	201174|Actinobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4583550_1	101510.RHA1_ro11219	4.779e-139	462.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FXJT@85025|Nocardiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_4583550_5	1123024.AUII01000010_gene679	5.146e-97	321.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4E0T5@85010|Pseudonocardiales	201174|Actinobacteria	KP	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
HFD2_k127_4583550_6	1123024.AUII01000052_gene3914	2.963e-89	303.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4EEKA@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_4583550_4	1463921.JODF01000002_gene3096	1.959e-106	392.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
HFD2_k127_4583550_11	383372.Rcas_3381	2.031e-26	129.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia	32061|Chloroflexia	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD2_k127_4583550_9	653045.Strvi_5056	5.185e-35	157.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
HFD2_k127_4595040_1	1313172.YM304_24510	1.476e-125	412.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4CNAA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_4595040_2	1313172.YM304_24520	2.047e-110	378.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_4595040_0	1123320.KB889675_gene4065	1.071e-172	553.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_4595040_11	1449346.JQMO01000003_gene6074	0.0008417	51.0	2DPFI@1|root,331V5@2|Bacteria,2I130@201174|Actinobacteria,2M3GS@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
HFD2_k127_4595040_7	1313172.YM304_24550	1.696e-67	241.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_4595040_5	1313172.YM304_24560	2.13e-87	304.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4CNWM@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD2_k127_4595040_6	1144275.COCOR_06036	4.554e-87	296.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2YU2N@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD2_k127_4595040_3	1068980.ARVW01000001_gene4797	1.668e-95	323.0	COG3191@1|root,COG3191@2|Bacteria,2GJKQ@201174|Actinobacteria,4DY61@85010|Pseudonocardiales	201174|Actinobacteria	EQ	PFAM Peptidase family S58	dmpA	-	-	ko:K18572	ko00332,ko01130,map00332,map01130	-	R10752	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Peptidase_S58
HFD2_k127_4595040_9	1182590.BN5_03010	7.155e-48	181.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,1S88D@1236|Gammaproteobacteria,1YFDA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	lidK	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_4595040_4	1313172.YM304_24600	3.761e-89	300.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria	201174|Actinobacteria	M	Acetyltransferase (isoleucine patch	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HFD2_k127_4595040_8	1313172.YM304_24620	3.473e-56	207.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_4646406_4	1313172.YM304_18510	1.059e-133	434.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CMTA@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HFD2_k127_4646406_0	1313172.YM304_18530	0.0	1063.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD2_k127_4646406_9	110319.CF8_2857	1.386e-62	229.0	2E9GJ@1|root,333PP@2|Bacteria	2|Bacteria	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
HFD2_k127_4646406_15	406817.XNC1_4141	1.854e-34	145.0	28M8C@1|root,2ZAMI@2|Bacteria,1R981@1224|Proteobacteria,1SMPK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4646406_14	1068978.AMETH_2617	5.301e-35	137.0	COG3324@1|root,COG3324@2|Bacteria,2IRUY@201174|Actinobacteria,4E6ZQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_4646406_19	9361.ENSDNOP00000007737	0.0008316	44.0	COG0326@1|root,COG5076@1|root,KOG0019@2759|Eukaryota,KOG1778@2759|Eukaryota,38G23@33154|Opisthokonta,3BAGN@33208|Metazoa,3CRQD@33213|Bilateria,483FJ@7711|Chordata,48W13@7742|Vertebrata,3JCCX@40674|Mammalia	33208|Metazoa	K	MRF binding	CREBBP	GO:0000003,GO:0000075,GO:0000076,GO:0000122,GO:0000123,GO:0000228,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0000785,GO:0000790,GO:0000793,GO:0000940,GO:0000976,GO:0000977,GO:0000981,GO:0000982,GO:0000987,GO:0000988,GO:0000989,GO:0001012,GO:0001067,GO:0001076,GO:0001078,GO:0001085,GO:0001091,GO:0001093,GO:0001098,GO:0001099,GO:0001102,GO:0001191,GO:0001227,GO:0001228,GO:0001505,GO:0001654,GO:0001666,GO:0001736,GO:0001738,GO:0001745,GO:0001751,GO:0001752,GO:0001754,GO:0001817,GO:0001818,GO:0001819,GO:0002009,GO:0002039,GO:0002064,GO:0002065,GO:0002066,GO:0002218,GO:0002220,GO:0002223,GO:0002253,GO:0002376,GO:0002429,GO:0002520,GO:0002682,GO:0002684,GO:0002757,GO:0002758,GO:0002764,GO:0002768,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003684,GO:0003690,GO:0003700,GO:0003712,GO:0003713,GO:0003824,GO:0004402,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005700,GO:0005737,GO:0006139,GO:0006325,GO:0006351,GO:0006352,GO:0006355,GO:0006357,GO:0006366,GO:0006367,GO:0006464,GO:0006473,GO:0006474,GO:0006475,GO:0006479,GO:0006725,GO:0006807,GO:0006810,GO:0006836,GO:0006928,GO:0006950,GO:0006996,GO:0007088,GO:0007154,GO:0007163,GO:0007164,GO:0007165,GO:0007166,GO:0007219,GO:0007221,GO:0007224,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0007399,GO:0007416,GO:0007423,GO:0007464,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008140,GO:0008150,GO:0008152,GO:0008213,GO:0008270,GO:0008283,GO:0008347,GO:0008589,GO:0008593,GO:0009058,GO:0009059,GO:0009266,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010484,GO:0010556,GO:0010557,GO:0010558,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0010941,GO:0016043,GO:0016055,GO:0016070,GO:0016407,GO:0016410,GO:0016477,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016604,GO:0016605,GO:0016740,GO:0016746,GO:0016747,GO:0018022,GO:0018076,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019216,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019827,GO:0019899,GO:0019904,GO:0019953,GO:0022008,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0023061,GO:0030097,GO:0030111,GO:0030154,GO:0030177,GO:0030178,GO:0030182,GO:0030326,GO:0030707,GO:0030718,GO:0030855,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031347,GO:0031349,GO:0031365,GO:0031570,GO:0031647,GO:0031648,GO:0031974,GO:0031981,GO:0032259,GO:0032479,GO:0032480,GO:0032481,GO:0032501,GO:0032502,GO:0032504,GO:0032648,GO:0032688,GO:0032774,GO:0032793,GO:0032922,GO:0032940,GO:0032991,GO:0033043,GO:0033554,GO:0033613,GO:0034097,GO:0034212,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034708,GO:0034968,GO:0035097,GO:0035107,GO:0035108,GO:0035113,GO:0035728,GO:0035729,GO:0036211,GO:0036293,GO:0036294,GO:0040011,GO:0040040,GO:0042035,GO:0042036,GO:0042063,GO:0042067,GO:0042221,GO:0042592,GO:0042706,GO:0042733,GO:0042975,GO:0042981,GO:0043067,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0043425,GO:0043426,GO:0043543,GO:0043565,GO:0043618,GO:0043620,GO:0043900,GO:0043901,GO:0043903,GO:0043933,GO:0043966,GO:0043967,GO:0043971,GO:0043974,GO:0043982,GO:0043983,GO:0043993,GO:0044017,GO:0044085,GO:0044093,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0044798,GO:0045088,GO:0045089,GO:0045165,GO:0045357,GO:0045358,GO:0045466,GO:0045475,GO:0045595,GO:0045637,GO:0045747,GO:0045786,GO:0045787,GO:0045892,GO:0045893,GO:0045931,GO:0045934,GO:0045935,GO:0045944,GO:0046332,GO:0046483,GO:0046530,GO:0046552,GO:0046872,GO:0046903,GO:0046914,GO:0046982,GO:0046983,GO:0048056,GO:0048468,GO:0048477,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048525,GO:0048534,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048598,GO:0048609,GO:0048663,GO:0048699,GO:0048729,GO:0048731,GO:0048736,GO:0048749,GO:0048856,GO:0048869,GO:0048870,GO:0050776,GO:0050778,GO:0050789,GO:0050792,GO:0050793,GO:0050794,GO:0050808,GO:0050896,GO:0051090,GO:0051091,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051568,GO:0051604,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0051783,GO:0060173,GO:0060255,GO:0060353,GO:0060355,GO:0060429,GO:0060828,GO:0061418,GO:0061733,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070482,GO:0070555,GO:0070848,GO:0070887,GO:0071214,GO:0071310,GO:0071363,GO:0071453,GO:0071456,GO:0071478,GO:0071482,GO:0071704,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090068,GO:0090090,GO:0090263,GO:0090304,GO:0090575,GO:0090596,GO:0097159,GO:0097659,GO:0097718,GO:0098586,GO:0098687,GO:0098727,GO:0098916,GO:0099536,GO:0099537,GO:0099643,GO:0104004,GO:0140110,GO:0198738,GO:1900034,GO:1900087,GO:1901222,GO:1901224,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902493,GO:1902494,GO:1902531,GO:1902533,GO:1902679,GO:1902680,GO:1902806,GO:1902808,GO:1903506,GO:1903507,GO:1903508,GO:1903706,GO:1904837,GO:1905114,GO:1990226,GO:1990234,GO:1990837,GO:2000026,GO:2000045,GO:2000112,GO:2000113,GO:2001141	2.3.1.48	ko:K04498	ko04024,ko04066,ko04068,ko04110,ko04310,ko04330,ko04350,ko04520,ko04630,ko04720,ko04916,ko04919,ko04922,ko05016,ko05152,ko05161,ko05164,ko05165,ko05166,ko05167,ko05168,ko05169,ko05200,ko05203,ko05206,ko05211,ko05215,map04024,map04066,map04068,map04110,map04310,map04330,map04350,map04520,map04630,map04720,map04916,map04919,map04922,map05016,map05152,map05161,map05164,map05165,map05166,map05167,map05168,map05169,map05200,map05203,map05206,map05211,map05215	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03029,ko03036	-	-	-	Bromodomain,Creb_binding,DUF902,HAT_KAT11,KIX,ZZ,zf-TAZ
HFD2_k127_4646406_6	1408419.JHYG01000009_gene35	2.527e-79	280.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,2JPUE@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_4646406_16	1007103.AFHW01000016_gene5963	2.626e-25	122.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HBTP@91061|Bacilli,26RM7@186822|Paenibacillaceae	91061|Bacilli	I	acyl-CoA dehydrogenase	ydbM	-	-	-	-	-	-	-	-	-	-	iYO844.BSU04520	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_4646406_1	1463855.JOHV01000010_gene5536	2.093e-157	513.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria	201174|Actinobacteria	E	Acetylornithine deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_4646406_2	1121441.AUCX01000010_gene162	6.541e-147	477.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,42NVH@68525|delta/epsilon subdivisions,2WJN9@28221|Deltaproteobacteria,2MAYM@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD2_k127_4646406_10	1313172.YM304_18580	1.462e-56	203.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CN8I@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HFD2_k127_4646406_11	1313172.YM304_18590	7.102e-51	190.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CN4E@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_4646406_7	1313172.YM304_18600	3.265e-76	260.0	COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4646406_12	1313172.YM304_18630	6.071e-39	151.0	COG1399@1|root,COG1399@2|Bacteria,2HGH0@201174|Actinobacteria,4CNEE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HFD2_k127_4646406_17	1313172.YM304_18640	2.633e-22	97.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HFD2_k127_4646406_3	1313172.YM304_18650	1.438e-138	447.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CMRM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD2_k127_4646406_13	1313172.YM304_18660	3.847e-36	139.0	COG0236@1|root,COG0236@2|Bacteria,2HG9V@201174|Actinobacteria,4CN8D@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD2_k127_4646406_8	1313172.YM304_18670	2.235e-71	258.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4CN7Y@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD2_k127_4646406_5	1313172.YM304_18680	3.96e-99	329.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4CN5C@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	mutM	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_4694175_26	1313172.YM304_22240	1.983e-27	121.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria,4CMV3@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HFD2_k127_4694175_11	42256.RradSPS_1896	1.542e-80	300.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_4694175_1	1313172.YM304_22260	0.0	1122.0	COG0560@1|root,COG3320@1|root,COG0560@2|Bacteria,COG3320@2|Bacteria,2GJVX@201174|Actinobacteria,4CMQQ@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4
HFD2_k127_4694175_13	1313172.YM304_22270	4.991e-73	259.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD2_k127_4694175_9	258052.JNYV01000002_gene1542	1.436e-117	407.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,2M0JG@2063|Kitasatospora	201174|Actinobacteria	M	D-ala D-ala ligase N-terminus	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD2_k127_4694175_6	1313172.YM304_22300	2.414e-131	449.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4CN8B@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Mur ligase family, glutamate ligase domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_4694175_16	1056816.JAFQ01000003_gene7357	1.305e-52	189.0	COG3576@1|root,COG3576@2|Bacteria,2I7E8@201174|Actinobacteria,4G9QX@85025|Nocardiaceae	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_4694175_4	1313172.YM304_22430	2.643e-162	520.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	cyp279A2	-	-	-	-	-	-	-	-	-	-	-	p450
HFD2_k127_4694175_3	1313172.YM304_22440	4.867e-178	566.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4CMQC@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD2_k127_4694175_20	1313172.YM304_22450	2.479e-51	187.0	COG1522@1|root,COG1522@2|Bacteria,2HA3J@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HFD2_k127_4694175_2	1155714.KB891987_gene3310	1.206e-234	733.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	prr1	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_4694175_22	101510.RHA1_ro02769	5.209e-37	146.0	2ADQJ@1|root,313FX@2|Bacteria,2H0DG@201174|Actinobacteria,4G1UD@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_27	404380.Gbem_2013	5.552e-26	111.0	2DQJB@1|root,3377V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_17	1155714.KB891987_gene3309	2.15e-52	193.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HFD2_k127_4694175_7	1151122.AQYD01000006_gene1704	4.224e-128	430.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FKHX@85023|Microbacteriaceae	201174|Actinobacteria	E	TOBE domain	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HFD2_k127_4694175_8	1348338.ADILRU_1846	1.23e-118	395.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4FNX3@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	SBP_bac_8,TAT_signal
HFD2_k127_4694175_12	1194165.CAJF01000006_gene2517	3.265e-77	270.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4FKXK@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HFD2_k127_4694175_18	312284.A20C1_10299	2.214e-52	208.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,3UWPB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
HFD2_k127_4694175_10	321332.CYB_1677	2.094e-92	314.0	COG0111@1|root,COG0111@2|Bacteria,1G417@1117|Cyanobacteria,1H2J2@1129|Synechococcus	1117|Cyanobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_4694175_23	1146883.BLASA_4018	2.77e-34	149.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
HFD2_k127_4694175_28	1183438.GKIL_2707	1.459e-15	86.0	COG0484@1|root,COG0484@2|Bacteria,1G2FB@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
HFD2_k127_4694175_21	1454004.AW11_01835	5.145e-40	173.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2VX35@28216|Betaproteobacteria	28216|Betaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_14	1304883.KI912532_gene1361	5.451e-62	245.0	COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales	206389|Rhodocyclales	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT
HFD2_k127_4694175_24	526225.Gobs_2513	1.283e-33	138.0	COG0457@1|root,COG0457@2|Bacteria,2GSU3@201174|Actinobacteria,4EWQT@85013|Frankiales	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_25	870187.Thini_1988	1.363e-28	132.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631,DUF2510,PknH_C,TIR_2
HFD2_k127_4694175_15	326424.FRAAL1883	1.173e-54	203.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4ES9S@85013|Frankiales	201174|Actinobacteria	L	exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD2_k127_4694175_29	215803.DB30_8356	4.914e-10	62.0	2EPV2@1|root,33HFI@2|Bacteria,1P4JW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_19	1240349.ANGC01000014_gene583	1.409e-51	187.0	2CJDS@1|root,32110@2|Bacteria,2INBK@201174|Actinobacteria,4G1RT@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4694175_0	1435356.Y013_17680	0.0	1199.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4FXDH@85025|Nocardiaceae	201174|Actinobacteria	CP	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123,ko:K02567	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200	M00529,M00530	R00519,R00798,R01106	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_4694175_5	929712.KI912613_gene201	7.286e-132	437.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4CS63@84995|Rubrobacteria	84995|Rubrobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_4701268_11	1206730.BAGA01000098_gene5893	7.383e-10	72.0	COG0681@1|root,COG0681@2|Bacteria,2IR4K@201174|Actinobacteria,4G0UT@85025|Nocardiaceae	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD2_k127_4701268_8	1313172.YM304_13790	2.567e-45	176.0	COG2755@1|root,COG2755@2|Bacteria,2H8GH@201174|Actinobacteria	201174|Actinobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_4701268_10	1229780.BN381_290139	2.831e-23	106.0	2FJAX@1|root,34B0V@2|Bacteria,2H7B1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4701268_3	1313172.YM304_22530	9.566e-96	320.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4CN5B@84992|Acidimicrobiia	84992|Acidimicrobiia	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_4701268_7	1313172.YM304_22540	2.718e-64	238.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	lytH	-	-	ko:K06401,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3289,Peptidase_M23,SH3_3
HFD2_k127_4701268_2	1313172.YM304_22570	2.457e-149	488.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CMPY@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HFD2_k127_4701268_0	1313172.YM304_22580	1.232e-247	789.0	COG1164@1|root,COG1164@2|Bacteria,2IGPX@201174|Actinobacteria	201174|Actinobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HFD2_k127_4701268_5	1313172.YM304_22590	1.857e-79	286.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4CN0X@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HFD2_k127_4701268_6	1048339.KB913029_gene1225	1.71e-71	262.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4ERX8@85013|Frankiales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD2_k127_4701268_1	1313172.YM304_22610	2.257e-156	501.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CMYU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_4701268_4	1313172.YM304_22620	1.007e-87	297.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CN2F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HFD2_k127_4703047_28	1313172.YM304_03760	6.12e-82	276.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_4703047_41	1313172.YM304_03770	1.576e-37	144.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	yphI	-	1.14.99.57	ko:K06996,ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
HFD2_k127_4703047_29	1313172.YM304_03780	8.843e-82	280.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
HFD2_k127_4703047_23	1313172.YM304_03800	6.698e-91	332.0	COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria	201174|Actinobacteria	M	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_4703047_43	1313172.YM304_34800	1.118e-25	119.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K07004,ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,HYR,fn3
HFD2_k127_4703047_4	1313172.YM304_03900	6.663e-182	582.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMRN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HFD2_k127_4703047_22	404589.Anae109_1694	4.163e-96	327.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_4703047_19	1313172.YM304_36900	1.286e-102	342.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HFD2_k127_4703047_27	1313172.YM304_36890	8.628e-85	290.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
HFD2_k127_4703047_17	1313172.YM304_36880	7.245e-109	379.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HFD2_k127_4703047_30	1313172.YM304_36860	3.305e-77	263.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4CN2J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HFD2_k127_4703047_10	1313172.YM304_36840	1.333e-142	462.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria	201174|Actinobacteria	J	protein conserved in bacteria	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
HFD2_k127_4703047_12	1313172.YM304_36810	1.459e-136	454.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria	201174|Actinobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_4703047_24	390989.JOEG01000004_gene3996	1.301e-89	306.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4D8HT@85008|Micromonosporales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HFD2_k127_4703047_20	1313172.YM304_36790	2.864e-102	344.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4CN8A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_4703047_14	1313172.YM304_37080	8.807e-127	413.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4CMYP@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DisA bacterial checkpoint controller linker region	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N
HFD2_k127_4703047_6	1313172.YM304_37070	5.173e-163	524.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4CNUD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	KaiC	-	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase
HFD2_k127_4703047_38	1313172.YM304_37030	1.62e-44	171.0	28Z32@1|root,2ZKVK@2|Bacteria,2HCTJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4703047_40	1313172.YM304_29580	7.517e-41	157.0	COG1595@1|root,COG1595@2|Bacteria,2HGZ0@201174|Actinobacteria,4CNZ2@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_4703047_44	1313172.YM304_29560	2.937e-25	119.0	COG3391@1|root,COG3391@2|Bacteria,2IC6X@201174|Actinobacteria	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4703047_0	1229780.BN381_150076	0.0	1339.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,3UWDQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HFD2_k127_4703047_13	1313172.YM304_03920	1.385e-130	425.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CMZ7@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_4703047_5	1229780.BN381_450016	1.154e-173	553.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,3UX9K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	FAD binding domain	menJ	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_4703047_32	1313172.YM304_03980	9.244e-72	254.0	COG2010@1|root,COG2010@2|Bacteria,2H5KX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4703047_36	1313172.YM304_03990	2.016e-56	210.0	2C3UQ@1|root,341WW@2|Bacteria,2H6NT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4703047_33	1313172.YM304_04000	1.854e-71	243.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
HFD2_k127_4703047_8	1313172.YM304_04010	3.806e-151	479.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
HFD2_k127_4703047_15	1313172.YM304_04020	2.152e-115	377.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
HFD2_k127_4703047_25	1313172.YM304_04030	1.344e-88	302.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD2_k127_4703047_11	1313172.YM304_04040	6.296e-137	447.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_4703047_31	1313172.YM304_04050	3.311e-75	266.0	2FE68@1|root,34663@2|Bacteria,2H83B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4703047_35	1313172.YM304_04060	1.449e-58	215.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4CN51@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD2_k127_4703047_21	1313172.YM304_04070	3.109e-98	332.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD2_k127_4703047_34	1313172.YM304_04080	1.938e-61	216.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4CN4G@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_4703047_3	1313172.YM304_04090	3.958e-237	747.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HFD2_k127_4703047_26	1313172.YM304_04100	4.786e-86	288.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4CN1U@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD2_k127_4703047_2	1313172.YM304_04110	9.599e-246	773.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4CMQ2@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
HFD2_k127_4703047_1	1313172.YM304_04120	1.129e-307	962.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CMPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HFD2_k127_4703047_7	1313172.YM304_04130	6.522e-161	516.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD2_k127_4703047_16	1313172.YM304_04140	7.682e-113	366.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HFD2_k127_4703047_37	1313172.YM304_04150	6.937e-46	179.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4CN8Y@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD2_k127_4703047_42	1313172.YM304_04160	3.72e-30	136.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CN4N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD2_k127_4703047_9	1313172.YM304_04170	1.585e-149	479.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia	84992|Acidimicrobiia	CP	protein synonym multiple resistance and pH homeostasis protein A	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HFD2_k127_4714947_9	875328.JDM601_2408	2.048e-18	86.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,232FY@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4714947_4	1313172.YM304_24030	2.646e-105	346.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_4714947_0	1313172.YM304_24020	1.388e-160	518.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4CNAM@84992|Acidimicrobiia	84992|Acidimicrobiia	HQ	chorismate binding enzyme	-	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
HFD2_k127_4714947_1	1313172.YM304_24010	1.796e-147	488.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4CN69@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD2_k127_4714947_7	1313172.YM304_24000	2.928e-70	244.0	COG2761@1|root,COG2761@2|Bacteria,2GNBC@201174|Actinobacteria	201174|Actinobacteria	Q	Dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_4714947_8	1192034.CAP_1582	3.748e-66	234.0	COG2267@1|root,COG2267@2|Bacteria,1QUFU@1224|Proteobacteria,43BQ1@68525|delta/epsilon subdivisions,2X718@28221|Deltaproteobacteria,2Z3MK@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
HFD2_k127_4714947_5	1313172.YM304_23980	2.441e-95	320.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CN0D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD2_k127_4714947_2	1313172.YM304_23970	1.294e-111	374.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4CN14@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4714947_6	479432.Sros_7428	5.625e-80	284.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4ENDZ@85012|Streptosporangiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD2_k127_4714947_3	1313172.YM304_23960	3.277e-106	353.0	COG1028@1|root,COG1028@2|Bacteria,2HF91@201174|Actinobacteria,4CN32@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_4714947_10	1123504.JQKD01000046_gene1169	5.1e-15	78.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,4AAVV@80864|Comamonadaceae	28216|Betaproteobacteria	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HFD2_k127_4775425_11	1313172.YM304_42220	3.866e-24	102.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_4775425_9	526226.Gbro_0449	1.732e-48	180.0	COG0454@1|root,COG0456@2|Bacteria,2HXQB@201174|Actinobacteria,4GGM9@85026|Gordoniaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HFD2_k127_4775425_0	28042.GU90_02290	1.677e-157	509.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4E04A@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.12	ko:K00248,ko:K14448	ko00071,ko00280,ko00630,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00630,map00650,map01100,map01110,map01120,map01200,map01212	M00373	R01175,R01178,R02661,R03172,R04751,R09293	RC00052,RC00068,RC00076,RC00120,RC00148,RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_4775425_4	330084.JNYZ01000038_gene4172	1.418e-58	212.0	COG2030@1|root,COG2030@2|Bacteria,2IK9K@201174|Actinobacteria,4EB10@85010|Pseudonocardiales	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_4775425_7	330084.JNYZ01000038_gene4170	3.489e-51	188.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_4775425_5	1172185.KB911517_gene1660	1.167e-53	196.0	COG1309@1|root,COG1309@2|Bacteria,2IBKZ@201174|Actinobacteria,4G12N@85025|Nocardiaceae	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HFD2_k127_4775425_1	1172185.KB911517_gene1681	7.903e-107	365.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4FZPN@85025|Nocardiaceae	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD2_k127_4775425_6	1449065.JMLL01000010_gene571	1.732e-51	197.0	COG0697@1|root,COG0697@2|Bacteria,1RHZ4@1224|Proteobacteria,2UAU7@28211|Alphaproteobacteria,43IZY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_4775425_2	2002.JOEQ01000055_gene462	1.402e-100	337.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4EGXG@85012|Streptosporangiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_4775425_10	1123320.KB889681_gene2587	1.731e-29	122.0	COG3631@1|root,COG3631@2|Bacteria,2ISRH@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_4775425_8	1313172.YM304_42300	1.084e-50	188.0	COG0346@1|root,COG0346@2|Bacteria,2IJX2@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4775425_3	69395.JQLZ01000005_gene3832	6.552e-72	251.0	COG3324@1|root,COG3324@2|Bacteria,1RBHJ@1224|Proteobacteria,2U6F9@28211|Alphaproteobacteria,2KIHB@204458|Caulobacterales	204458|Caulobacterales	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4775425_12	1313172.YM304_42050	3.443e-21	95.0	COG0402@1|root,COG0402@2|Bacteria,2I9BJ@201174|Actinobacteria,4CN7U@84992|Acidimicrobiia	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_485077_4	419947.MRA_3676	1.274e-76	260.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,234FU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
HFD2_k127_485077_14	1239962.C943_01301	1.657e-11	76.0	COG1073@1|root,COG1073@2|Bacteria,4NM3J@976|Bacteroidetes,47WHG@768503|Cytophagia	976|Bacteroidetes	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD2_k127_485077_3	1229780.BN381_330019	8.814e-99	328.0	COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria,3UX9S@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA5	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_485077_9	1122622.ATWJ01000010_gene1250	1.059e-49	179.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4FH87@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans	fkbP	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD2_k127_485077_12	1229780.BN381_350157	1.611e-26	126.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	MA20_36950	-	-	ko:K17362	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	4HBT
HFD2_k127_485077_6	1313172.YM304_01790	5.559e-66	241.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HFD2_k127_485077_2	483219.LILAB_33085	1.995e-116	388.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NCK@68525|delta/epsilon subdivisions,2WMCF@28221|Deltaproteobacteria,2YTU4@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HFD2_k127_485077_0	1313172.YM304_25760	0.0	1291.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4CMXT@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HFD2_k127_485077_1	1313172.YM304_25740	5.829e-141	455.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4CMQS@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Glycine cleavage T-protein C-terminal barrel domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_485077_8	1313172.YM304_25730	2.32e-51	186.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_485077_11	1313172.YM304_25720	3.887e-44	169.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4CN3Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HFD2_k127_485077_7	1313172.YM304_25710	1.95e-65	232.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CN7E@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_485077_5	1313172.YM304_25700	4.748e-69	238.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4CN4F@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl,zinc_ribbon_2
HFD2_k127_485077_13	1313172.YM304_25690	4.343e-26	108.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CN5F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD2_k127_4869588_15	1313172.YM304_10850	7.694e-42	157.0	COG3427@1|root,COG3427@2|Bacteria,2HGAK@201174|Actinobacteria,4CNA2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_4869588_4	1313172.YM304_10860	5.294e-143	460.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4CMV6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
HFD2_k127_4869588_10	1313172.YM304_12290	1.39e-68	243.0	COG0500@1|root,COG0500@2|Bacteria,2I3YC@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_4869588_3	1313172.YM304_12550	8.982e-144	465.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4CN5Q@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_4869588_5	1313172.YM304_12560	4.139e-139	469.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CMY8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA methyl transferase	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD2_k127_4869588_12	1313172.YM304_12570	1.185e-48	186.0	2CDEB@1|root,2ZRID@2|Bacteria,2HDK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4869588_9	1313172.YM304_12580	9.153e-94	321.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_4869588_1	1229780.BN381_10084	1.026e-253	799.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,3UW7F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD2_k127_4869588_7	1313172.YM304_12630	1.385e-125	425.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,Pkinase_Tyr
HFD2_k127_4869588_6	1313172.YM304_12640	8.4e-130	421.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_4869588_14	1313172.YM304_12650	6.685e-46	182.0	COG3255@1|root,COG3255@2|Bacteria,2HGCC@201174|Actinobacteria,4CNAG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4869588_2	1313172.YM304_12700	2.381e-242	758.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4CMQA@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_4869588_8	640081.Dsui_1359	3.587e-104	346.0	COG0284@1|root,COG0284@2|Bacteria,1MWH5@1224|Proteobacteria,2VHAB@28216|Betaproteobacteria,2KUGT@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HFD2_k127_4869588_16	68219.JNXI01000010_gene5735	2.463e-33	137.0	COG1018@1|root,COG4097@1|root,COG1018@2|Bacteria,COG4097@2|Bacteria,2GJCV@201174|Actinobacteria	201174|Actinobacteria	C	Flavodoxin reductases ferredoxin-NADPH reductases family 1	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,p450
HFD2_k127_4869588_13	68219.JNXI01000010_gene5736	7.613e-48	186.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD2_k127_4869588_18	1313172.YM304_12730	5.473e-22	96.0	COG1141@1|root,COG1141@2|Bacteria,2HH2S@201174|Actinobacteria,4CP2W@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Divergent 4Fe-4S mono-cluster	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HFD2_k127_4869588_19	1313172.YM304_12740	5.285e-18	92.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,Excalibur,SNase
HFD2_k127_4869588_0	1229780.BN381_450030	1.337e-277	870.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,3UW8G@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD2_k127_4869588_11	1504319.GM45_3420	5.182e-59	208.0	COG5310@1|root,COG5310@2|Bacteria,2IRSZ@201174|Actinobacteria	201174|Actinobacteria	Q	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD2_k127_4882462_33	1313172.YM304_20100	1.918e-13	73.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria	201174|Actinobacteria	G	xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_4882462_25	1313172.YM304_20110	5.946e-39	152.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,TPR_2,WD40
HFD2_k127_4882462_10	1278073.MYSTI_01666	1.909e-96	325.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42T6S@68525|delta/epsilon subdivisions,2WP34@28221|Deltaproteobacteria,2YV20@29|Myxococcales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	yrdC1	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HFD2_k127_4882462_18	1313172.YM304_20130	1.504e-68	254.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_4882462_1	1313172.YM304_20140	3.047e-224	703.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HFD2_k127_4882462_16	1313172.YM304_20150	4.192e-73	251.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4CNDQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Cytidylate kinase	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD2_k127_4882462_17	1313172.YM304_20160	7.897e-71	253.0	COG0204@1|root,COG0204@2|Bacteria,2HG51@201174|Actinobacteria,4CN6X@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_4882462_6	1313172.YM304_20170	7.504e-147	482.0	COG1362@1|root,COG1362@2|Bacteria,2GKW4@201174|Actinobacteria	201174|Actinobacteria	E	M18 family aminopeptidase	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
HFD2_k127_4882462_15	1313172.YM304_20180	2.278e-73	254.0	COG0406@1|root,COG0406@2|Bacteria,2GM22@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_4882462_4	1313172.YM304_20190	6.261e-165	531.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4CMXD@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HFD2_k127_4882462_28	1283283.ATXA01000010_gene4499	3.728e-29	130.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_4882462_22	1313172.YM304_20220	5.21e-48	175.0	2DMMI@1|root,32SFN@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
HFD2_k127_4882462_29	468556.AQYG01000048_gene627	3.043e-23	106.0	COG0746@1|root,COG0746@2|Bacteria,2IACX@201174|Actinobacteria,4GDUP@85026|Gordoniaceae	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_4882462_30	685727.REQ_34660	1.424e-21	102.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4G383@85025|Nocardiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_4882462_5	1313172.YM304_20250	2.297e-148	479.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CN02@84992|Acidimicrobiia	84992|Acidimicrobiia	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HFD2_k127_4882462_11	1313172.YM304_20260	9.008e-87	293.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria	201174|Actinobacteria	D	chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD2_k127_4882462_2	1382359.JIAL01000001_gene577	5.576e-210	673.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_4882462_9	1313172.YM304_20280	6.698e-98	325.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4882462_0	1211114.ALIP01000113_gene866	1.774e-232	747.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD2_k127_4882462_26	1313172.YM304_20300	1.44e-36	144.0	COG0816@1|root,COG0816@2|Bacteria,2HGE6@201174|Actinobacteria,4CNCG@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD2_k127_4882462_8	1313172.YM304_20310	5.719e-119	406.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4CN7T@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD2_k127_4882462_12	1313172.YM304_20320	3.314e-85	304.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4CN43@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HFD2_k127_4882462_3	1313172.YM304_20340	6.502e-191	611.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CMPX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD2_k127_4882462_21	1313172.YM304_20350	1.737e-50	187.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4CNCU@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HFD2_k127_4882462_7	1313172.YM304_20360	1.136e-134	440.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CMXJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	3-dehydroquinate synthase	aroB	-	-	ko:K16020	ko01051,ko01130,map01051,map01130	-	R06592	RC00847	ko00000,ko00001	-	-	-	DHQ_synthase
HFD2_k127_4882462_19	1217718.ALOU01000023_gene4131	1.399e-56	210.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2VQS6@28216|Betaproteobacteria,1K8JN@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_4882462_20	1229780.BN381_50135	4.581e-51	186.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,3UWWA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786,ko:K16021	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230	M00022	R03084,R06593	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HFD2_k127_4882462_14	1313172.YM304_20370	1.079e-81	286.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CN22@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_4882462_13	1121877.JQKF01000024_gene2404	3.556e-82	278.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD2_k127_4882462_23	1313172.YM304_20390	6.52e-41	158.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4CNC8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD2_k127_4882462_24	1313172.YM304_20400	1.122e-40	169.0	COG3463@1|root,COG3463@2|Bacteria	2|Bacteria	T	Predicted membrane protein (DUF2079)	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2079,HisKA_3
HFD2_k127_4882462_27	1244869.H261_07798	3.744e-36	155.0	COG2227@1|root,COG2227@2|Bacteria,1NB77@1224|Proteobacteria,2UFRN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD2_k127_4882462_32	246196.MSMEI_3769	6.769e-18	98.0	COG0463@1|root,COG0463@2|Bacteria,2IPT1@201174|Actinobacteria,234JK@1762|Mycobacteriaceae	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD2_k127_4933609_0	1869.MB27_06535	6.494e-136	439.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4DAH3@85008|Micromonosporales	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
HFD2_k127_4933609_2	1313304.CALK_0445	4.254e-68	244.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD2_k127_4933609_4	749927.AMED_2684	8.356e-32	127.0	COG0640@1|root,COG0640@2|Bacteria,2IR66@201174|Actinobacteria,4E6K9@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0044212,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HFD2_k127_4933609_3	1380390.JIAT01000015_gene5746	3.26e-61	220.0	COG3832@1|root,COG3832@2|Bacteria,2IG6F@201174|Actinobacteria	201174|Actinobacteria	K	PFAM Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_4933609_1	1121877.JQKF01000018_gene2559	4.396e-75	258.0	COG0842@1|root,COG0842@2|Bacteria,2GP9E@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_4962795_1	1035308.AQYY01000001_gene2785	2.288e-80	277.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_4962795_4	1035308.AQYY01000001_gene2784	4.461e-34	139.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HFD2_k127_4962795_0	35754.JNYJ01000014_gene4744	8.634e-147	478.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,4DA52@85008|Micromonosporales	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
HFD2_k127_4962795_7	1121877.JQKF01000014_gene5	1.307e-12	76.0	COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_4962795_2	1229780.BN381_170012	2.921e-68	242.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria	201174|Actinobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HFD2_k127_4962795_3	644283.Micau_2764	2.386e-64	229.0	COG0500@1|root,COG2226@2|Bacteria,2I36Q@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_4962795_5	1869.MB27_07585	4.105e-23	103.0	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria,4DFX8@85008|Micromonosporales	201174|Actinobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HFD2_k127_4962795_6	711393.AYRX01000077_gene579	1.524e-16	85.0	COG2905@1|root,COG2905@2|Bacteria,2IJJ6@201174|Actinobacteria	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_4992210_5	1313172.YM304_12250	1.817e-115	376.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_4992210_8	1313172.YM304_12240	3.303e-90	316.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_4992210_1	1313172.YM304_12220	5.919e-166	530.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4CNIM@84992|Acidimicrobiia	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	megL	-	2.5.1.48,2.5.1.49,4.4.1.11	ko:K01739,ko:K01740,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01287,R01288,R02508,R03217,R03260,R04770,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_4992210_20	504728.K649_08725	1.829e-11	77.0	COG1647@1|root,COG1647@2|Bacteria,1WI99@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HFD2_k127_4992210_9	1313172.YM304_12150	3.67e-87	297.0	COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria,2HGAJ@201174|Actinobacteria,4CN9Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	NifU-like domain	-	-	-	ko:K07400	-	-	-	-	ko00000	-	-	-	NifU
HFD2_k127_4992210_6	365528.KB891212_gene2263	4.06e-102	340.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4EU6E@85013|Frankiales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD2_k127_4992210_17	1313172.YM304_11770	5.372e-36	144.0	COG1564@1|root,COG1564@2|Bacteria	2|Bacteria	H	THIamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
HFD2_k127_4992210_7	1313172.YM304_11760	2.473e-100	349.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	thiB	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
HFD2_k127_4992210_2	1313172.YM304_11750	3.205e-144	490.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
HFD2_k127_4992210_13	67257.JODR01000008_gene3662	9.781e-64	225.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
HFD2_k127_4992210_12	1385519.N801_14600	1.126e-64	226.0	COG0262@1|root,COG0262@2|Bacteria,2GJU5@201174|Actinobacteria,4FJID@85021|Intrasporangiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_4992210_21	929712.KI912613_gene1501	6.684e-11	71.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria	201174|Actinobacteria	T	universal stress protein	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4992210_19	1283299.AUKG01000001_gene3401	1.069e-21	110.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4CPNT@84995|Rubrobacteria	84995|Rubrobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_4992210_18	1313172.YM304_11730	1.9e-28	120.0	COG0454@1|root,COG0456@2|Bacteria,2IMKI@201174|Actinobacteria,4CNE6@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HFD2_k127_4992210_14	267608.RSc0221	7.179e-40	162.0	COG1752@1|root,COG1752@2|Bacteria,1MX8Y@1224|Proteobacteria,2VKNF@28216|Betaproteobacteria,1K0PA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_4992210_15	391037.Sare_1013	1.904e-39	169.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4D8PB@85008|Micromonosporales	201174|Actinobacteria	P	resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HFD2_k127_4992210_16	1121272.KB903251_gene855	3.575e-38	151.0	2C7TJ@1|root,31RF6@2|Bacteria,2GP9X@201174|Actinobacteria,4D9XX@85008|Micromonosporales	201174|Actinobacteria	G	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	5.2.1.4	ko:K16163	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	MDMPI_C,MDMPI_N
HFD2_k127_4992210_3	1313172.YM304_11700	2.074e-135	452.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4CMUX@84992|Acidimicrobiia	84992|Acidimicrobiia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD2_k127_4992210_0	1313172.YM304_11690	1.241e-232	726.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CNFV@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_4992210_10	1313172.YM304_11620	6.336e-84	296.0	COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria	201174|Actinobacteria	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_4992210_4	1313172.YM304_11610	6.375e-128	419.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HFD2_k127_4992210_11	1313172.YM304_11600	7.781e-71	244.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HFD2_k127_5025893_2	1313172.YM304_35550	1.048e-123	403.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_5025893_3	1313172.YM304_35500	2.505e-114	379.0	COG1565@1|root,COG1565@2|Bacteria	2|Bacteria	P	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD2_k127_5025893_6	266779.Meso_0048	5.552e-32	145.0	COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,2UC86@28211|Alphaproteobacteria,43MTR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HFD2_k127_5025893_0	1313172.YM304_35460	0.0	1072.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4CMRX@84992|Acidimicrobiia	84992|Acidimicrobiia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_5025893_4	1313172.YM304_35430	2.723e-67	232.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4CN1Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF520)	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HFD2_k127_5025893_1	1121877.JQKF01000038_gene1818	4.148e-174	565.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4CNGN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran
HFD2_k127_5025893_5	1313172.YM304_07840	1.667e-55	199.0	COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria,4CN6Q@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HFD2_k127_5025893_7	1313172.YM304_08160	7.761e-16	78.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_5275608_7	1313172.YM304_02520	6.908e-39	160.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	ko:K12204	-	-	-	-	ko00000,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	Amidase_2,FecR,LysM,PG_binding_1,SLT
HFD2_k127_5275608_5	1313172.YM304_35100	1.267e-47	180.0	COG3217@1|root,COG3217@2|Bacteria	2|Bacteria	S	molybdenum ion binding	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HFD2_k127_5275608_6	1313172.YM304_01360	2.781e-39	155.0	2DNEF@1|root,32X3P@2|Bacteria,2GPZ8@201174|Actinobacteria	201174|Actinobacteria	S	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
HFD2_k127_5275608_0	1313172.YM304_01340	1.64e-165	533.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD2_k127_5275608_3	1313172.YM304_01330	1.637e-59	219.0	COG4965@1|root,COG4965@2|Bacteria	2|Bacteria	U	Type ii secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
HFD2_k127_5275608_4	1313172.YM304_01320	1.099e-53	210.0	COG2064@1|root,COG2064@2|Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_5275608_16	365528.KB891250_gene5840	9.125e-07	58.0	COG4961@1|root,COG4961@2|Bacteria,2GRCJ@201174|Actinobacteria,4ET7Q@85013|Frankiales	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_5275608_1	1313172.YM304_01270	3.486e-155	532.0	COG1388@1|root,COG1652@1|root,COG1388@2|Bacteria,COG1652@2|Bacteria,2I8YV@201174|Actinobacteria	201174|Actinobacteria	NU	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD2_k127_5275608_10	1194165.CAJF01000025_gene3270	2.343e-25	117.0	2B9CE@1|root,322Q4@2|Bacteria,2IKT2@201174|Actinobacteria,4FPVN@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
HFD2_k127_5275608_12	649831.L083_4605	1.389e-21	99.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4DEUJ@85008|Micromonosporales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD2_k127_5275608_13	526225.Gobs_1322	9.434e-16	88.0	COG0711@1|root,COG0711@2|Bacteria,2IQQZ@201174|Actinobacteria,4EW8R@85013|Frankiales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5275608_2	926569.ANT_27970	1.292e-141	471.0	COG3227@1|root,COG4412@1|root,COG3227@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.21.50,3.4.24.28	ko:K01337,ko:K01400,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,FTP,Glyco_hydro_31,PA,Peptidase_M4,Peptidase_M4_C,Peptidase_M6,Peptidase_S8,W_rich_C
HFD2_k127_5289263_7	1230476.C207_01049	2.294e-19	102.0	COG0778@1|root,COG0778@2|Bacteria,1Q7UM@1224|Proteobacteria,2VDZM@28211|Alphaproteobacteria,3JX3R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_5289263_3	316274.Haur_0338	5.659e-119	391.0	COG0604@1|root,COG0604@2|Bacteria,2G9Z7@200795|Chloroflexi,377GH@32061|Chloroflexia	32061|Chloroflexia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5289263_4	1313172.YM304_29050	6.83e-106	349.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CNTU@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD2_k127_5289263_0	1313172.YM304_29030	3.039e-203	637.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CMRS@84992|Acidimicrobiia	84992|Acidimicrobiia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
HFD2_k127_5289263_2	2074.JNYD01000010_gene926	7.29e-126	407.0	COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria,4E37X@85010|Pseudonocardiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_5289263_6	1313172.YM304_28980	9.379e-36	145.0	COG0251@1|root,COG0251@2|Bacteria,2IJMC@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_5289263_1	1313172.YM304_28970	6.718e-128	415.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMX5@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_5296691_14	1313172.YM304_07640	2.875e-09	59.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_5296691_11	1313172.YM304_07660	3.242e-37	143.0	2CC1Y@1|root,32TCV@2|Bacteria,2HGD4@201174|Actinobacteria,4CNAQ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HFD2_k127_5296691_12	525909.Afer_0327	4.279e-23	103.0	2FBA6@1|root,343GA@2|Bacteria,2H78Y@201174|Actinobacteria,4CN8Z@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5296691_0	1313172.YM304_07680	6.024e-293	915.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4CMSJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HFD2_k127_5296691_4	446470.Snas_2214	9.293e-110	364.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_5296691_8	1313172.YM304_07730	6.492e-89	304.0	COG0704@1|root,COG0704@2|Bacteria,2HGEH@201174|Actinobacteria,4CNCK@84992|Acidimicrobiia	84992|Acidimicrobiia	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HFD2_k127_5296691_7	1313172.YM304_07740	1.412e-89	306.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4CMZJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HFD2_k127_5296691_5	1313172.YM304_07750	3.126e-103	340.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_5296691_10	1229780.BN381_130090	1.204e-60	227.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,3UXIH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5296691_3	1313172.YM304_07800	1.307e-139	453.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4CNC4@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
HFD2_k127_5296691_6	1313172.YM304_09000	7.234e-97	327.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_5296691_9	1313172.YM304_09020	1.108e-67	239.0	COG0314@1|root,COG0314@2|Bacteria,2HG21@201174|Actinobacteria,4CN80@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HFD2_k127_5296691_1	1313172.YM304_09040	1.082e-193	609.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	201174|Actinobacteria	D	Cell division protein FtsA	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD2_k127_5296691_2	685778.AORL01000013_gene2016	8.055e-160	515.0	COG0557@1|root,COG0557@2|Bacteria,1R4RK@1224|Proteobacteria,2TTRC@28211|Alphaproteobacteria,2K2TK@204457|Sphingomonadales	204457|Sphingomonadales	K	RNB	-	-	-	-	-	-	-	-	-	-	-	-	RNB
HFD2_k127_5296691_13	457425.XNR_0158	2.165e-11	66.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
HFD2_k127_5306571_29	1298863.AUEP01000013_gene4011	1.156e-11	69.0	2B2IY@1|root,31V42@2|Bacteria,2GUYA@201174|Actinobacteria,4DS4M@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5306571_20	1380390.JIAT01000010_gene3840	1.889e-41	165.0	COG3920@1|root,COG5002@1|root,COG3920@2|Bacteria,COG5002@2|Bacteria,2HFEI@201174|Actinobacteria,4CTJF@84995|Rubrobacteria	84995|Rubrobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
HFD2_k127_5306571_1	935866.JAER01000044_gene2851	4.054e-218	693.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4DT81@85009|Propionibacteriales	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_5306571_21	67257.JODR01000006_gene2671	1.795e-40	154.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_5306571_19	408672.NBCG_04123	8.723e-42	159.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria,4DR4P@85009|Propionibacteriales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5306571_32	1121946.AUAX01000025_gene6418	2.249e-07	59.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
HFD2_k127_5306571_25	446469.Sked_02690	2.663e-26	120.0	COG4244@1|root,COG4244@2|Bacteria,2I2FH@201174|Actinobacteria	201174|Actinobacteria	S	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD2_k127_5306571_31	1227499.C493_22046	2.019e-07	62.0	COG0589@1|root,arCOG02053@2157|Archaea,2XXSN@28890|Euryarchaeota,23WGX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5306571_8	926564.KI911644_gene2492	4.729e-103	367.0	COG3569@1|root,COG3569@2|Bacteria,2GJTH@201174|Actinobacteria,4F3C6@85017|Promicromonosporaceae	201174|Actinobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HFD2_k127_5306571_30	1313172.YM304_37590	1.135e-10	68.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	ANTAR,MEDS,PAS_3,STAS,STAS_2
HFD2_k127_5306571_2	1385518.N798_03700	4.831e-141	476.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4FJ4K@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_5306571_33	1160718.SU9_02085	1.043e-06	57.0	COG2172@1|root,COG2172@2|Bacteria,2ICET@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HFD2_k127_5306571_9	1313172.YM304_34010	7.145e-100	331.0	COG1028@1|root,COG1028@2|Bacteria,2I95F@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	ko:K14633	ko01057,ko01130,map01057,map01130	-	R09309,R09310	RC02484	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_5306571_12	1313172.YM304_31990	9.588e-76	259.0	COG2193@1|root,COG2193@2|Bacteria,2I9JJ@201174|Actinobacteria	201174|Actinobacteria	P	Rubrerythrin	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_5306571_13	543632.JOJL01000011_gene6812	5.999e-71	250.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4DCZ6@85008|Micromonosporales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD2_k127_5306571_15	1160137.KB907308_gene6991	6.331e-55	202.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4G4IQ@85025|Nocardiaceae	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
HFD2_k127_5306571_14	1229780.BN381_90043	1.743e-57	209.0	COG3228@1|root,COG3228@2|Bacteria,2H5QX@201174|Actinobacteria	201174|Actinobacteria	S	Glucose-regulated metallo-peptidase M90	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
HFD2_k127_5306571_6	1380356.JNIK01000011_gene1912	2.75e-111	365.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4EUJ1@85013|Frankiales	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_5306571_17	1125863.JAFN01000001_gene1570	4.668e-47	186.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_5306571_23	1244869.H261_12206	3.676e-34	152.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TZIJ@28211|Alphaproteobacteria,2JZ34@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD2_k127_5306571_4	1123023.JIAI01000004_gene8269	3.634e-130	443.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DZTZ@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5306571_28	468556.AQYG01000050_gene2924	8.607e-18	94.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4GAEI@85026|Gordoniaceae	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
HFD2_k127_5306571_5	1121933.AUHH01000003_gene1334	2.217e-116	384.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DQPN@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_5306571_22	1828.JOKB01000065_gene4171	1.923e-39	157.0	COG3281@1|root,COG3281@2|Bacteria,2GPHW@201174|Actinobacteria,4G0HD@85025|Nocardiaceae	201174|Actinobacteria	G	Trehalose synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5306571_24	1123023.JIAI01000006_gene342	2.798e-29	133.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,M20_dimer,Peptidase_M20
HFD2_k127_5306571_11	1123023.JIAI01000006_gene341	1.817e-82	287.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_5306571_0	1304865.JAGF01000001_gene1065	2.924e-288	902.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4F323@85016|Cellulomonadaceae	201174|Actinobacteria	J	elongation factor Tu domain 2 protein	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_5306571_7	1121946.AUAX01000032_gene489	2.712e-108	379.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DAB5@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF
HFD2_k127_5306571_3	1313172.YM304_23940	9.199e-140	451.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4CMTR@84992|Acidimicrobiia	84992|Acidimicrobiia	T	AAA domain	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HFD2_k127_5306571_16	1313172.YM304_23950	4.188e-47	176.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CN8G@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HFD2_k127_5306571_10	1121877.JQKF01000022_gene2275	4.953e-93	323.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HFD2_k127_5306571_26	298654.FraEuI1c_5047	2.553e-21	99.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,4ERGA@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_5310829_15	215803.DB30_6353	5.381e-14	83.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,TSP_3
HFD2_k127_5310829_1	1120949.KB903299_gene5956	1.676e-155	516.0	COG3055@1|root,COG3055@2|Bacteria,2IA06@201174|Actinobacteria	201174|Actinobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5310829_4	1313172.YM304_37400	8.551e-76	269.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4CMXY@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_5310829_0	1386089.N865_05255	8.99e-173	559.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4FFFU@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HFD2_k127_5310829_2	1380370.JIBA01000010_gene2581	2.91e-93	320.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4FFGI@85021|Intrasporangiaceae	201174|Actinobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_5310829_14	574966.KB898655_gene1520	3.817e-24	115.0	COG3000@1|root,COG3000@2|Bacteria,1MYGK@1224|Proteobacteria,1T0VZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydroxylase	crtZ	-	1.14.15.24	ko:K15746	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00372	R07530,R07558,R07559,R07561,R07562,R07568,R07569,R07570,R07572,R07851,R09747	RC00478,RC00704,RC02629	ko00000,ko00001,ko00002,ko01000	-	-	-	FA_hydroxylase
HFD2_k127_5310829_13	1385518.N798_05420	1.374e-26	121.0	2E9V0@1|root,3340V@2|Bacteria,2GVC5@201174|Actinobacteria	201174|Actinobacteria	S	carotenoid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5310829_8	1385518.N798_05425	1.595e-56	214.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21,Glycos_transf_2
HFD2_k127_5310829_9	397278.JOJN01000012_gene2193	1.466e-35	141.0	2E9MI@1|root,333U6@2|Bacteria,2IMX9@201174|Actinobacteria,4DS9I@85009|Propionibacteriales	201174|Actinobacteria	S	lycopene cyclase	crtYd	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5310829_12	1380370.JIBA01000010_gene2585	9.17e-29	118.0	arCOG05416@1|root,33310@2|Bacteria,2IQR4@201174|Actinobacteria,4FHER@85021|Intrasporangiaceae	201174|Actinobacteria	S	lycopene cyclase	crtYc	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5310829_7	1313172.YM304_29460	5.33e-57	209.0	COG5012@1|root,COG5012@2|Bacteria,2GKAY@201174|Actinobacteria	201174|Actinobacteria	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HFD2_k127_5310829_11	1089453.GOSPT_072_00150	5.773e-29	124.0	COG1266@1|root,COG1266@2|Bacteria,2I925@201174|Actinobacteria,4GDWG@85026|Gordoniaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_5310829_3	247156.NFA_11930	5.447e-78	275.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4FXFF@85025|Nocardiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,TspO_MBR
HFD2_k127_5310829_10	2074.JNYD01000016_gene4262	4.13e-35	139.0	COG3427@1|root,COG3427@2|Bacteria,2ISXG@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_5310829_5	1354722.JQLS01000008_gene910	1.064e-59	215.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria,46PIN@74030|Roseovarius	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
HFD2_k127_5310829_6	1382356.JQMP01000004_gene455	1.776e-59	211.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	BNR,BNR_2,CBM_2,RicinB_lectin_2
HFD2_k127_5342000_0	1313172.YM304_08010	0.0	1607.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CMT4@84992|Acidimicrobiia	84992|Acidimicrobiia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HFD2_k127_5342000_2	1313172.YM304_08090	8.494e-60	220.0	COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4CN6J@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD2_k127_5342000_1	1229780.BN381_180002	2.765e-73	249.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,3UWK1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD2_k127_5342000_3	2074.JNYD01000006_gene1673	1.817e-38	149.0	COG3832@1|root,COG3832@2|Bacteria,2IPH4@201174|Actinobacteria,4EBCP@85010|Pseudonocardiales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD2_k127_5365885_11	765420.OSCT_1324	6.319e-111	369.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7
HFD2_k127_5365885_23	1869.MB27_42635	2.202e-77	262.0	COG2128@1|root,COG2128@2|Bacteria,2H4IP@201174|Actinobacteria,4DJ9G@85008|Micromonosporales	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_5365885_35	1123023.JIAI01000002_gene5746	4.438e-37	142.0	COG1733@1|root,COG1733@2|Bacteria,2GSST@201174|Actinobacteria,4ED6P@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD2_k127_5365885_33	1333523.L593_08510	4.106e-47	182.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
HFD2_k127_5365885_45	1380370.JIBA01000018_gene551	7.753e-06	57.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4FF88@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD2_k127_5365885_13	1380347.JNII01000006_gene1305	1.263e-107	355.0	COG5588@1|root,COG5588@2|Bacteria,2HIPH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HFD2_k127_5365885_9	526225.Gobs_0843	2.823e-125	411.0	COG5486@1|root,COG5486@2|Bacteria,2IAYZ@201174|Actinobacteria	201174|Actinobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HFD2_k127_5365885_1	649638.Trad_1961	1.301e-309	981.0	COG0474@1|root,COG0474@2|Bacteria,1WICW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD2_k127_5365885_27	383372.Rcas_2660	1.439e-65	243.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi,3777S@32061|Chloroflexia	32061|Chloroflexia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_5365885_28	357808.RoseRS_3062	6.558e-64	229.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,377FQ@32061|Chloroflexia	32061|Chloroflexia	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_5365885_20	1313172.YM304_27880	1.215e-84	289.0	COG0589@1|root,COG0589@2|Bacteria,2HF8Z@201174|Actinobacteria,4CNUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5365885_25	875328.JDM601_0086	6.681e-68	236.0	COG0346@1|root,COG0346@2|Bacteria,2GW3K@201174|Actinobacteria,23DCQ@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_5365885_7	1123023.JIAI01000001_gene6118	9.076e-142	459.0	COG1073@1|root,COG1073@2|Bacteria,2H0FD@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5365885_37	1254432.SCE1572_01075	6.271e-30	128.0	COG1418@1|root,COG1418@2|Bacteria,1MV0J@1224|Proteobacteria,43CJG@68525|delta/epsilon subdivisions,2X7TV@28221|Deltaproteobacteria,2YVYA@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HFD2_k127_5365885_24	1123024.AUII01000033_gene1401	2.052e-72	252.0	COG0596@1|root,COG0596@2|Bacteria,2IAKH@201174|Actinobacteria,4E9MU@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_5365885_38	263358.VAB18032_18030	1.881e-20	106.0	COG0500@1|root,COG2226@2|Bacteria,2IEAN@201174|Actinobacteria,4DM18@85008|Micromonosporales	201174|Actinobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
HFD2_k127_5365885_39	1027371.GOALK_056_00750	2.798e-19	97.0	COG3450@1|root,COG3450@2|Bacteria,2GSTB@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
HFD2_k127_5365885_29	1380390.JIAT01000013_gene125	1.242e-61	241.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4CQYN@84995|Rubrobacteria	84995|Rubrobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_5365885_47	246197.MXAN_3402	0.0008612	50.0	COG1876@1|root,COG1876@2|Bacteria,1NIJK@1224|Proteobacteria	1224|Proteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	TMP_2,VanY
HFD2_k127_5365885_6	33876.JNXY01000015_gene7455	1.046e-146	486.0	COG0467@1|root,COG0467@2|Bacteria,2I58C@201174|Actinobacteria,4DH7N@85008|Micromonosporales	201174|Actinobacteria	T	Circadian clock protein KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD2_k127_5365885_43	1192034.CAP_5213	9.378e-10	70.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,42X6D@68525|delta/epsilon subdivisions,2WSP0@28221|Deltaproteobacteria,2YVHJ@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HFD2_k127_5365885_46	479433.Caci_3398	7.932e-06	53.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
HFD2_k127_5365885_26	263358.VAB18032_19475	8.321e-68	238.0	COG2186@1|root,COG2186@2|Bacteria,2GJ82@201174|Actinobacteria,4DCCB@85008|Micromonosporales	201174|Actinobacteria	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_5365885_10	35754.JNYJ01000079_gene4336	1.034e-124	410.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4DDXV@85008|Micromonosporales	201174|Actinobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_5365885_17	543632.JOJL01000052_gene6489	1.18e-101	355.0	COG1129@1|root,COG1129@2|Bacteria,2IHB0@201174|Actinobacteria,4DI25@85008|Micromonosporales	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_5365885_12	35754.JNYJ01000079_gene4338	1.96e-110	367.0	COG1879@1|root,COG1879@2|Bacteria,2HEHI@201174|Actinobacteria,4DH2G@85008|Micromonosporales	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_5365885_4	103733.JNYO01000023_gene7204	9.255e-183	581.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,4DZ8G@85010|Pseudonocardiales	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.68	ko:K18334	ko00051,ko01120,map00051,map01120	-	R03688	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_5365885_18	1123322.KB904658_gene1265	2.223e-86	297.0	COG3618@1|root,COG3618@2|Bacteria,2GM2D@201174|Actinobacteria	201174|Actinobacteria	C	amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_5365885_15	1157637.KB892112_gene5221	3.914e-105	349.0	COG1028@1|root,COG1028@2|Bacteria,2GK78@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_5365885_31	1120954.ATXE01000001_gene2228	2.498e-48	184.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4DQ8R@85009|Propionibacteriales	201174|Actinobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HFD2_k127_5365885_8	1380356.JNIK01000017_gene2991	9.322e-133	446.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ES4U@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HFD2_k127_5365885_19	469383.Cwoe_0616	5.857e-86	291.0	COG4312@1|root,COG4312@2|Bacteria,2GIVC@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HFD2_k127_5365885_41	243365.CV_1439	3.432e-16	87.0	COG3832@1|root,COG3832@2|Bacteria,1RCZK@1224|Proteobacteria,2VR7G@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_5365885_36	861208.AGROH133_07294	5.294e-33	139.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,4BFXG@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	sdpR	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_5365885_44	1116375.VEJY3_20391	1.376e-09	63.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,1SGKM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD2_k127_5365885_16	55952.BU52_03405	6.822e-105	355.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_5365885_5	1957.JODX01000030_gene6042	9.644e-151	486.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_5365885_14	1440774.Y900_015625	2.244e-106	355.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD2_k127_5365885_2	330214.NIDE3851	3.935e-229	726.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_5365885_22	1150864.MILUP08_44194	3.022e-82	285.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria,4DDTD@85008|Micromonosporales	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_5365885_40	479432.Sros_3935	7.272e-18	87.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria,4EJN9@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_5365885_0	485913.Krac_2880	0.0	1380.0	COG3387@1|root,COG4945@1|root,COG3387@2|Bacteria,COG4945@2|Bacteria,2G69A@200795|Chloroflexi	200795|Chloroflexi	G	glycoside hydrolase 15-related	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_C,Glucodextran_N,Glyco_hydro_15
HFD2_k127_5365885_30	1122194.AUHU01000011_gene1692	8.738e-58	231.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,465SK@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
HFD2_k127_5365885_3	1123023.JIAI01000009_gene1154	4.315e-205	652.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4DYF3@85010|Pseudonocardiales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	cysD	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_5365885_32	1305732.JAGG01000001_gene166	5.331e-48	193.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4FMRD@85023|Microbacteriaceae	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD2_k127_5365885_21	234267.Acid_4640	1.618e-82	285.0	COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HFD2_k127_5365885_34	525904.Tter_2802	1.094e-37	156.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
HFD2_k127_5377518_7	1449346.JQMO01000003_gene6829	8.557e-59	219.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,2M5BF@2063|Kitasatospora	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HFD2_k127_5377518_9	443218.AS9A_2840	2.44e-45	173.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_5377518_10	1120934.KB894403_gene421	2.642e-44	182.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4E4FQ@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HFD2_k127_5377518_19	370438.PTH_0776	5.552e-15	86.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia,261NQ@186807|Peptococcaceae	186801|Clostridia	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_5377518_2	471852.Tcur_2408	7.925e-74	259.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4EFUR@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_5377518_6	1265310.CCBD010000074_gene5507	4.316e-59	216.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,236KX@1762|Mycobacteriaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigI	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5377518_3	1313172.YM304_21500	1.481e-73	273.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Beta_helix,Flg_new,HYR
HFD2_k127_5377518_13	1122609.AUGT01000009_gene3461	1.702e-34	136.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD2_k127_5377518_15	1449063.JMLS01000025_gene3931	6.133e-26	113.0	COG0431@1|root,COG0431@2|Bacteria,1VHXS@1239|Firmicutes,4HNPK@91061|Bacilli,26WTS@186822|Paenibacillaceae	91061|Bacilli	S	flavoprotein	M1-836	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HFD2_k127_5377518_11	350058.Mvan_4029	2.064e-42	175.0	COG2761@1|root,COG2761@2|Bacteria,2HWM3@201174|Actinobacteria,237V9@1762|Mycobacteriaceae	201174|Actinobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_5377518_17	1108045.GORHZ_069_00700	2.274e-20	101.0	2FB55@1|root,343BG@2|Bacteria,2IKSK@201174|Actinobacteria,4GGEP@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5377518_5	1157638.KB892191_gene4997	6.464e-65	230.0	COG1131@1|root,COG1131@2|Bacteria,2GP3F@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
HFD2_k127_5377518_16	1380354.JIAN01000005_gene1957	3.204e-24	112.0	2ASCZ@1|root,31HSE@2|Bacteria,2IEI1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5377518_1	1123320.KB889710_gene8466	2.091e-154	507.0	COG0683@1|root,COG0683@2|Bacteria,2GMDG@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_5377518_8	67373.JOBF01000017_gene5337	5.179e-55	203.0	COG0410@1|root,COG0410@2|Bacteria,2H96G@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_5377518_4	710111.FraQA3DRAFT_3489	3.426e-66	234.0	COG0411@1|root,COG0411@2|Bacteria,2IFYS@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_5377518_0	1123320.KB889710_gene8469	3.439e-172	560.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
HFD2_k127_5377518_14	479433.Caci_3349	4.45e-26	117.0	2917I@1|root,2ZNUP@2|Bacteria,2IRP8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5377518_18	1287116.X734_04265	1.57e-15	89.0	2C5WB@1|root,2Z7IZ@2|Bacteria,1RCRD@1224|Proteobacteria,2UEX3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5377518_12	1394178.AWOO02000093_gene8064	1.224e-36	156.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4EIJI@85012|Streptosporangiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD2_k127_5377518_20	35754.JNYJ01000038_gene5054	4.589e-06	57.0	COG2199@1|root,COG3903@1|root,COG3706@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DH3V@85008|Micromonosporales	201174|Actinobacteria	KT	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,TPR_12
HFD2_k127_5388724_12	1313172.YM304_37150	6.502e-68	232.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CN1B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HFD2_k127_5388724_3	1313172.YM304_37130	1.539e-187	592.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_5388724_16	1313172.YM304_16100	1.231e-47	186.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HFD2_k127_5388724_2	1313172.YM304_37120	3.1e-210	660.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4CMSB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5388724_11	1229780.BN381_150047	2.606e-68	235.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,3UWVQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HFD2_k127_5388724_23	1463895.JODA01000033_gene3075	6.346e-13	75.0	COG2165@1|root,COG2165@2|Bacteria,2I4YC@201174|Actinobacteria	201174|Actinobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD2_k127_5388724_18	105422.BBPM01000038_gene939	3.809e-40	165.0	2BYV5@1|root,301S5@2|Bacteria,2HCUJ@201174|Actinobacteria,2NM3S@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5388724_9	1313172.YM304_02750	4.019e-84	289.0	COG4923@1|root,COG4923@2|Bacteria	2|Bacteria	K	Protein of unknown function (DUF429)	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF429
HFD2_k127_5388724_4	1313172.YM304_02740	1.387e-172	549.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4CNKQ@84992|Acidimicrobiia	84992|Acidimicrobiia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD2_k127_5388724_10	1313172.YM304_02730	7.957e-74	256.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4CP3Z@84992|Acidimicrobiia	84992|Acidimicrobiia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD2_k127_5388724_5	1313172.YM304_02720	2.147e-172	559.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4CNRV@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD2_k127_5388724_1	1313172.YM304_02700	4.432e-250	784.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4CNFH@84992|Acidimicrobiia	84992|Acidimicrobiia	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_5388724_13	1313172.YM304_02690	3.394e-57	217.0	COG5185@1|root,COG5185@2|Bacteria	2|Bacteria	D	Phage-related minor tail protein	-	-	-	ko:K15771,ko:K18642,ko:K20444	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000,ko04812	3.A.1.1.16,3.A.1.1.2,4.D.1.3	GT2,GT4	-	BPD_transp_1,DUF4175,DivIVA,TMP_2,Tape_meas_lam_C
HFD2_k127_5388724_7	1313172.YM304_02680	2.181e-118	387.0	COG0258@1|root,COG0258@2|Bacteria,2H2A3@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease, C-terminal SAM fold	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HFD2_k127_5388724_14	1313172.YM304_02670	1.965e-52	190.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4CN9M@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HFD2_k127_5388724_22	28444.JODQ01000009_gene3703	3.653e-13	74.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,4EJNW@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
HFD2_k127_5388724_20	1340493.JNIF01000003_gene2598	3.697e-24	113.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_5388724_25	1313172.YM304_07640	1.733e-08	60.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_5388724_24	234267.Acid_6005	1.104e-12	74.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_5388724_21	1463841.JOIR01000021_gene3136	5.518e-23	103.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria	201174|Actinobacteria	K	pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	HTH_3,HTH_31,Pyridox_ox_2
HFD2_k127_5388724_15	446466.Cfla_0420	1.339e-48	184.0	COG0789@1|root,COG0789@2|Bacteria,2INKP@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
HFD2_k127_5388724_17	1283283.ATXA01000027_gene157	5.017e-45	169.0	COG1309@1|root,COG1309@2|Bacteria,2IIY2@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_5388724_6	1313172.YM304_02630	1.031e-133	444.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria	2|Bacteria	NU	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD2_k127_5388724_0	1313172.YM304_02620	3.419e-266	834.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CMW8@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_5388724_8	1313172.YM304_37360	7.273e-105	353.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4CN7J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD2_k127_5390952_4	179408.Osc7112_0411	0.0001331	52.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Glyco_hydro_25,PG_binding_1
HFD2_k127_5390952_0	1313172.YM304_02490	7.586e-144	463.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CN0G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HFD2_k127_5390952_1	1157637.KB892091_gene5889	2.441e-49	195.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HFD2_k127_5390952_3	47839.CCAU010000013_gene4849	2.43e-16	89.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,23DDH@1762|Mycobacteriaceae	201174|Actinobacteria	HT	Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD2_k127_5390952_2	1192034.CAP_7905	1.387e-40	160.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2YUU1@29|Myxococcales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD2_k127_5399163_0	356851.JOAN01000024_gene4478	1.163e-284	884.0	COG1452@1|root,COG1452@2|Bacteria,2GNM6@201174|Actinobacteria,4DMCF@85008|Micromonosporales	201174|Actinobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HFD2_k127_5399163_5	33876.JNXY01000009_gene9081	7.233e-11	63.0	COG3408@1|root,COG3408@2|Bacteria,2IB24@201174|Actinobacteria,4D8TX@85008|Micromonosporales	201174|Actinobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD2_k127_5399163_2	298654.FraEuI1c_6619	1.835e-63	224.0	COG1595@1|root,COG1595@2|Bacteria,2I9C1@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5399163_4	298654.FraEuI1c_6618	1.505e-11	67.0	COG5660@1|root,COG5660@2|Bacteria,2GQSP@201174|Actinobacteria	201174|Actinobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_5399163_1	1313172.YM304_07120	1.814e-94	316.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD2_k127_5399163_3	926550.CLDAP_30800	1.181e-53	197.0	COG1052@1|root,COG1052@2|Bacteria,2G7VK@200795|Chloroflexi	200795|Chloroflexi	C	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_5401394_7	1097668.BYI23_B002270	4.254e-79	273.0	COG0793@1|root,COG0793@2|Bacteria,1R88N@1224|Proteobacteria,2W1SE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HFD2_k127_5401394_10	710685.MycrhN_2847	1.892e-64	226.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,234NT@1762|Mycobacteriaceae	201174|Actinobacteria	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_5401394_1	1050202.KB913024_gene1462	4.716e-97	331.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4084I@622450|Actinopolysporales	201174|Actinobacteria	E	Cobalamin-independent synthase, Catalytic domain	metE2	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_5401394_13	365528.KB891263_gene602	3.792e-53	216.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4ESZE@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_5401394_17	1306990.BARG01000002_gene155	2.14e-37	164.0	COG0483@1|root,COG0483@2|Bacteria,2IH5M@201174|Actinobacteria	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_5401394_2	1463861.JNXE01000041_gene7890	7.473e-93	340.0	COG0715@1|root,COG0715@2|Bacteria,2GN9B@201174|Actinobacteria	201174|Actinobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
HFD2_k127_5401394_12	1123065.ATWL01000007_gene3162	4.275e-56	199.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_5401394_5	1394178.AWOO02000008_gene2942	1.506e-84	290.0	COG0662@1|root,COG0662@2|Bacteria,2IA7I@201174|Actinobacteria	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5401394_9	1246995.AFR_15720	2.747e-72	256.0	COG3836@1|root,COG3836@2|Bacteria,2HGEA@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD2_k127_5401394_6	66874.JOFS01000006_gene4390	6.872e-83	293.0	COG0683@1|root,COG0683@2|Bacteria,2IAH6@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_5401394_0	1172180.KB911780_gene7273	8.042e-216	689.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_5401394_8	1172180.KB911780_gene7274	3.712e-77	287.0	COG0411@1|root,COG0411@2|Bacteria,2I3FF@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_5401394_4	543632.JOJL01000013_gene9383	2.38e-89	314.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DBWH@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_5401394_3	1313172.YM304_36140	5.263e-91	311.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,GerE,TPR_16
HFD2_k127_5401394_16	1157638.KB892207_gene6992	1.151e-38	151.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_5401394_15	1313172.YM304_32450	2.181e-46	183.0	COG1285@1|root,COG1285@2|Bacteria,2GJF0@201174|Actinobacteria,4CP2B@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HFD2_k127_5401394_19	1380370.JIBA01000012_gene3430	4.446e-05	49.0	COG1948@1|root,COG1948@2|Bacteria,2HAMQ@201174|Actinobacteria,4FF1Z@85021|Intrasporangiaceae	201174|Actinobacteria	L	ERCC4 domain	-	-	-	-	-	-	-	-	-	-	-	-	ERCC4,Lsr2
HFD2_k127_5401394_14	1386089.N865_16490	1.799e-49	187.0	COG0508@1|root,COG0508@2|Bacteria,2I8Q8@201174|Actinobacteria,4FEUV@85021|Intrasporangiaceae	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
HFD2_k127_5401394_11	298654.FraEuI1c_3982	7.639e-61	212.0	COG0346@1|root,COG0346@2|Bacteria,2IPA6@201174|Actinobacteria,4EW05@85013|Frankiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_5401394_18	222534.KB893717_gene2176	2.22e-20	101.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,Cytochrom_C
HFD2_k127_5405007_4	1313172.YM304_08540	8.952e-23	98.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_5405007_2	1313172.YM304_08530	2.992e-96	324.0	COG3828@1|root,COG3828@2|Bacteria,2IB11@201174|Actinobacteria	201174|Actinobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
HFD2_k127_5405007_1	1313172.YM304_08520	1.717e-140	456.0	COG1071@1|root,COG1071@2|Bacteria,2HFTJ@201174|Actinobacteria,4CNQW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HFD2_k127_5405007_0	1313172.YM304_08510	3.055e-147	480.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CNNS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Transketolase, pyrimidine binding domain	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_5405007_3	1313172.YM304_08500	5.015e-81	287.0	COG3199@1|root,COG3199@2|Bacteria,2IE2N@201174|Actinobacteria	201174|Actinobacteria	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
HFD2_k127_5405007_5	1313172.YM304_08490	4.1e-11	67.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_5432748_3	1313172.YM304_19570	1.084e-43	165.0	COG0597@1|root,COG0597@2|Bacteria,2HGGT@201174|Actinobacteria,4CNE4@84992|Acidimicrobiia	84992|Acidimicrobiia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD2_k127_5432748_2	1313172.YM304_19560	3.585e-49	186.0	COG1734@1|root,COG1734@2|Bacteria,2HH4M@201174|Actinobacteria,4CP4R@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5432748_0	35754.JNYJ01000061_gene2352	0.0	1451.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4D973@85008|Micromonosporales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HFD2_k127_5432748_1	1313172.YM304_19540	9.782e-55	203.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
HFD2_k127_5432748_4	1313172.YM304_19530	2.361e-33	132.0	COG1799@1|root,COG1799@2|Bacteria,2HGHD@201174|Actinobacteria,4CNES@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
HFD2_k127_5458907_9	1380347.JNII01000005_gene3610	5.035e-65	244.0	COG4235@1|root,COG4235@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	ko:K02200,ko:K04018	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
HFD2_k127_5458907_11	298654.FraEuI1c_7018	2.329e-51	191.0	COG1928@1|root,COG1928@2|Bacteria,2GQQV@201174|Actinobacteria	201174|Actinobacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5458907_19	1052684.PPM_2623	0.0003003	53.0	COG3757@1|root,COG3757@2|Bacteria,1UWJF@1239|Firmicutes,4I7NG@91061|Bacilli,26X3H@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl hydrolases family 25	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HFD2_k127_5458907_16	1123023.JIAI01000003_gene2810	5.9e-14	84.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5,SLH
HFD2_k127_5458907_3	378806.STAUR_2214	1.608e-102	341.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	MA20_27725	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HFD2_k127_5458907_2	1382315.JPOI01000001_gene2797	4.575e-103	357.0	COG0604@1|root,COG0604@2|Bacteria,1TPGR@1239|Firmicutes,4HACF@91061|Bacilli,1WFY6@129337|Geobacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	yhfP	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5458907_5	164757.Mjls_1882	1.487e-83	285.0	COG1028@1|root,COG1028@2|Bacteria,2HWDM@201174|Actinobacteria,2340P@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_5458907_7	1449048.JQKU01000009_gene559	1.335e-68	242.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,234T3@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA12_1	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_5458907_14	1123320.KB889689_gene500	2.689e-31	128.0	COG0394@1|root,COG0394@2|Bacteria	2|Bacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ywlE	-	2.7.7.87,3.1.3.48,3.9.1.2,5.3.1.6	ko:K01104,ko:K01808,ko:K07566,ko:K20201	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030,R10463	RC00376,RC00434,RC00745	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016	-	-	-	LMWPc
HFD2_k127_5458907_4	1415780.JPOG01000001_gene925	5.431e-93	314.0	COG2267@1|root,COG2267@2|Bacteria,1MUFB@1224|Proteobacteria,1RYM9@1236|Gammaproteobacteria,1X49N@135614|Xanthomonadales	135614|Xanthomonadales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_5458907_0	1440774.Y900_026265	3.686e-209	655.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,234II@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the thiolase family	ltp1_1	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_5458907_10	1150599.MPHLEI_03733	6.055e-54	196.0	COG1545@1|root,COG1545@2|Bacteria,2IH6P@201174|Actinobacteria,23998@1762|Mycobacteriaceae	201174|Actinobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
HFD2_k127_5458907_12	1463856.JOHY01000020_gene4437	7.649e-51	190.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria	201174|Actinobacteria	T	Protein tyrosine serine phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
HFD2_k127_5458907_1	864069.MicloDRAFT_00045150	1.29e-121	398.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,1JTRT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KQ	PFAM regulatory protein ArsR	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
HFD2_k127_5458907_6	1125973.JNLC01000001_gene45	2.606e-79	285.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,3JR7B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HFD2_k127_5458907_15	365528.KB891102_gene4283	8.587e-31	123.0	COG2261@1|root,COG2261@2|Bacteria,2GS37@201174|Actinobacteria,4ETMQ@85013|Frankiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_5458907_8	1313172.YM304_29230	2.17e-68	239.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria	201174|Actinobacteria	P	reversible hydration of carbon dioxide	can	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HFD2_k127_5458907_13	765698.Mesci_0654	4.943e-42	156.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,43QY1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
HFD2_k127_5473914_6	1313172.YM304_34720	1.005e-35	145.0	COG1785@1|root,COG3391@1|root,COG1785@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	phoA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.3.1	ko:K01077,ko:K07004,ko:K21449	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko02000,ko04147	1.B.40.2	-	-	Alk_phosphatase,CHU_C,HYR,fn3
HFD2_k127_5473914_0	1313172.YM304_32850	2.368e-159	507.0	COG0451@1|root,COG0451@2|Bacteria,2GP0W@201174|Actinobacteria	201174|Actinobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD2_k127_5473914_5	1229780.BN381_10301	4.256e-50	196.0	COG3829@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	devS	GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07682	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3
HFD2_k127_5473914_1	33876.JNXY01000053_gene7888	1.881e-155	501.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4DBJ2@85008|Micromonosporales	201174|Actinobacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD2_k127_5473914_2	1123320.KB889672_gene3741	1.802e-138	462.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria	201174|Actinobacteria	F	deiminase	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_5473914_3	1229780.BN381_130271	5.705e-83	285.0	COG0242@1|root,COG0242@2|Bacteria,2GNZ9@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD2_k127_5473914_4	1121020.JIAG01000003_gene2558	8.433e-64	219.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,1W7K0@1268|Micrococcaceae	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HFD2_k127_5490739_1	1229780.BN381_130269	2.193e-244	765.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,3UX1W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HFD2_k127_5490739_2	1380390.JIAT01000011_gene2459	1.505e-206	654.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4CPAC@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM phenylalanine histidine ammonia-lyase	-	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD2_k127_5490739_0	1313172.YM304_04480	2.125e-302	949.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CNJI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5490739_3	1157640.AQWO01000027_gene6679	9.378e-58	215.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_5490739_4	743836.AYNA01000044_gene1165	2.14e-36	145.0	COG3409@1|root,COG3409@2|Bacteria,1NH6K@1224|Proteobacteria	1224|Proteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HFD2_k127_5490739_5	1121946.AUAX01000012_gene6576	1.776e-08	65.0	COG1520@1|root,COG1572@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,2I9FJ@201174|Actinobacteria,4DCMA@85008|Micromonosporales	201174|Actinobacteria	M	Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin	-	-	-	-	-	-	-	-	-	-	-	-	ASH,F5_F8_type_C,LGFP,PQQ_2,PQQ_3
HFD2_k127_5524226_16	1227739.Hsw_2814	6.136e-13	82.0	COG4412@1|root,COG4412@2|Bacteria,4PM4A@976|Bacteroidetes	976|Bacteroidetes	UW	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,FTP,PA,Peptidase_M36,Peptidase_M6
HFD2_k127_5524226_6	1313172.YM304_05280	2.922e-89	319.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,PKD,SprB
HFD2_k127_5524226_8	1313172.YM304_04850	8.353e-66	231.0	COG0572@1|root,COG0572@2|Bacteria,2I98W@201174|Actinobacteria,4CN8F@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HFD2_k127_5524226_3	1313172.YM304_04880	1.428e-110	374.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4CN9A@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Glycerate kinase family	-	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HFD2_k127_5524226_1	1211815.CBYP010000016_gene2611	1.612e-156	520.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_5524226_13	1229780.BN381_150094	1.804e-29	120.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,3UXHU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD2_k127_5524226_0	525909.Afer_1846	4.839e-276	857.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CNG0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD2_k127_5524226_4	1313172.YM304_02290	1.815e-110	374.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,NAD_binding_8,Trp_halogenase
HFD2_k127_5524226_12	1522072.IL54_1822	1.309e-51	192.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2TRGG@28211|Alphaproteobacteria,2K1ZT@204457|Sphingomonadales	204457|Sphingomonadales	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD2_k127_5524226_2	1313172.YM304_04940	3.013e-113	372.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4CN5S@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HFD2_k127_5524226_7	1313172.YM304_04960	8.113e-80	272.0	COG3253@1|root,COG3253@2|Bacteria,2HG3V@201174|Actinobacteria,4CMZQ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HFD2_k127_5524226_11	1313172.YM304_04970	5.107e-60	225.0	COG0683@1|root,COG0683@2|Bacteria,2HFKF@201174|Actinobacteria,4CP0G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_5524226_10	1449976.KALB_7945	6.723e-64	246.0	COG1595@1|root,COG1595@2|Bacteria,2GJFK@201174|Actinobacteria,4E0JT@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
HFD2_k127_5524226_5	1313172.YM304_05030	1.077e-105	347.0	COG1051@1|root,COG1051@2|Bacteria,2HG6C@201174|Actinobacteria,4CN3B@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
HFD2_k127_5524226_9	1313172.YM304_05040	2.541e-64	225.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CN4A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HFD2_k127_5575905_20	1313172.YM304_08270	4.715e-37	141.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CN84@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD2_k127_5575905_2	1313172.YM304_08280	1.956e-147	472.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4CMT8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD2_k127_5575905_18	1313172.YM304_08290	6.511e-50	178.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4CN5R@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD2_k127_5575905_9	1313172.YM304_08300	5.995e-75	263.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4CNBP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD2_k127_5575905_3	1313172.YM304_08310	5.194e-142	459.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4CMU9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD2_k127_5575905_10	1313172.YM304_08320	6.29e-75	252.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4CN0S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HFD2_k127_5575905_24	1313172.YM304_08330	2.612e-18	86.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HFD2_k127_5575905_22	1122971.BAME01000023_gene2524	1.031e-29	120.0	COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,2FTXY@200643|Bacteroidia,22YB5@171551|Porphyromonadaceae	976|Bacteroidetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HFD2_k127_5575905_14	1313172.YM304_08350	4.512e-70	240.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4CMZN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HFD2_k127_5575905_21	1313172.YM304_08360	2.935e-35	140.0	COG0198@1|root,COG0198@2|Bacteria,2HGDN@201174|Actinobacteria,4CNBW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HFD2_k127_5575905_7	1313172.YM304_08370	2.617e-83	286.0	COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4CMX7@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HFD2_k127_5575905_23	1313172.YM304_08380	2.408e-28	115.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4CNZU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HFD2_k127_5575905_15	1313172.YM304_08390	7.145e-68	232.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4CN3X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HFD2_k127_5575905_11	1313172.YM304_08400	4.262e-74	253.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CMZ3@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HFD2_k127_5575905_19	1313172.YM304_08410	3.658e-42	161.0	COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4CNBZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD2_k127_5575905_8	1313172.YM304_08420	6.793e-79	274.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4CN34@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HFD2_k127_5575905_25	1313172.YM304_08430	2.262e-13	81.0	COG1841@1|root,COG1841@2|Bacteria,2HGDQ@201174|Actinobacteria,4CNC3@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HFD2_k127_5575905_17	1313172.YM304_08440	5.517e-55	197.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4CN1G@84992|Acidimicrobiia	84992|Acidimicrobiia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD2_k127_5575905_0	1313172.YM304_08450	5.176e-196	624.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4CMWZ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD2_k127_5575905_6	1313172.YM304_08460	1.699e-93	311.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4CMZ1@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD2_k127_5575905_13	1961.JOAK01000030_gene2789	6.625e-73	256.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria	201174|Actinobacteria	J	Methionine aminopeptidase	map2	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD2_k127_5575905_1	1313172.YM304_20440	1.762e-182	597.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CN0V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_5575905_4	1313172.YM304_20430	8.354e-123	409.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4CN9W@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_5575905_16	1313172.YM304_20420	4.104e-67	232.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4CNB0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD2_k127_5575905_5	1313172.YM304_28690	2.173e-114	389.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HFD2_k127_5575905_12	345341.KUTG_00490	2.562e-73	261.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4EAUR@85010|Pseudonocardiales	201174|Actinobacteria	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HFD2_k127_5605338_24	1313172.YM304_33440	8.808e-05	53.0	COG0248@1|root,COG0248@2|Bacteria	2|Bacteria	FP	Ppx GppA phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5605338_16	1229780.BN381_630015	2.365e-47	178.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,3UWSU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
HFD2_k127_5605338_15	1313172.YM304_33420	6.367e-70	245.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4CN4Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HFD2_k127_5605338_17	1313172.YM304_33410	6.138e-42	160.0	COG2068@1|root,COG2068@2|Bacteria,2HG9S@201174|Actinobacteria,4CN88@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MobA-like NTP transferase domain	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_5605338_2	395495.Lcho_2036	1.766e-155	522.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KKDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD2_k127_5605338_20	1313172.YM304_33400	1.495e-36	147.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glucosaminidase,NLPC_P60
HFD2_k127_5605338_5	1313172.YM304_33390	1.114e-132	430.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4CN04@84992|Acidimicrobiia	84992|Acidimicrobiia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD2_k127_5605338_21	1306174.JODP01000006_gene3139	6.919e-32	128.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD2_k127_5605338_4	1313172.YM304_33370	9.565e-143	463.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CNNX@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_5605338_7	1313172.YM304_33360	2.289e-128	439.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CMRT@84992|Acidimicrobiia	84992|Acidimicrobiia	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HFD2_k127_5605338_3	1313172.YM304_33350	6.795e-144	473.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HFD2_k127_5605338_18	570268.ANBB01000088_gene171	9.978e-38	153.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EJD9@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5605338_23	1348663.KCH_65880	4.23e-13	75.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,2M3AI@2063|Kitasatospora	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
HFD2_k127_5605338_19	1313172.YM304_27880	1.142e-36	152.0	COG0589@1|root,COG0589@2|Bacteria,2HF8Z@201174|Actinobacteria,4CNUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5605338_8	1313172.YM304_28400	9.681e-119	397.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
HFD2_k127_5605338_9	469383.Cwoe_3031	1.831e-117	394.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CRRF@84995|Rubrobacteria	84995|Rubrobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_5605338_6	1121877.JQKF01000007_gene1022	1.208e-130	430.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria	201174|Actinobacteria	O	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HFD2_k127_5605338_11	35754.JNYJ01000054_gene9714	5.226e-87	299.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DDBA@85008|Micromonosporales	201174|Actinobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
HFD2_k127_5605338_0	1121877.JQKF01000007_gene1024	0.0	1364.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMWW@84992|Acidimicrobiia	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5605338_13	146922.JOFU01000021_gene2388	2.288e-75	259.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
HFD2_k127_5605338_10	2074.JNYD01000012_gene204	3.515e-114	378.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXFH@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
HFD2_k127_5605338_12	1123024.AUII01000006_gene4591	5.031e-82	283.0	COG0583@1|root,COG0583@2|Bacteria,2I8WJ@201174|Actinobacteria,4E184@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5605338_1	1907.SGLAU_24410	2.434e-189	602.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD2_k127_5605338_22	1122611.KB903964_gene4907	8.303e-15	78.0	2E7QZ@1|root,3326A@2|Bacteria,2GR1A@201174|Actinobacteria,4EKGI@85012|Streptosporangiales	201174|Actinobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
HFD2_k127_5605338_14	1313172.YM304_33330	8.957e-72	255.0	COG0671@1|root,COG0671@2|Bacteria,2IAXK@201174|Actinobacteria	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_5630803_9	1313172.YM304_08270	1.204e-25	106.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CN84@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD2_k127_5630803_4	1313172.YM304_08260	6.731e-78	275.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CN29@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD2_k127_5630803_1	1313172.YM304_08250	9.645e-97	321.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CMZP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HFD2_k127_5630803_0	1229780.BN381_350018	4.867e-176	575.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,3UX33@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_5630803_6	390989.JOEG01000002_gene4338	4.188e-62	222.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4D8PS@85008|Micromonosporales	201174|Actinobacteria	P	TrkA-N domain	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_5630803_5	525909.Afer_1924	7.911e-65	232.0	COG0569@1|root,COG0569@2|Bacteria,2HH1S@201174|Actinobacteria,4CP21@84992|Acidimicrobiia	84992|Acidimicrobiia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_5630803_10	1306174.JODP01000013_gene7771	3.091e-12	73.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5630803_3	1313172.YM304_27130	7.612e-81	284.0	COG5285@1|root,COG5285@2|Bacteria,2IF9U@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_5630803_2	1313172.YM304_08190	7.325e-87	301.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_5630803_7	1313172.YM304_08170	3.103e-55	197.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4CN6W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HFD2_k127_5630803_8	1313172.YM304_08160	4.415e-31	122.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_5669868_26	1313172.YM304_24510	2.93e-23	103.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4CNAA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_5669868_11	1313172.YM304_24490	1.011e-100	334.0	COG0491@1|root,COG0491@2|Bacteria,2GNS6@201174|Actinobacteria	201174|Actinobacteria	P	PFAM Metallo-beta-lactamase superfamily	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5669868_25	1172188.KB911824_gene3350	1.935e-24	111.0	COG3714@1|root,COG3714@2|Bacteria,2IG79@201174|Actinobacteria,4FGG0@85021|Intrasporangiaceae	201174|Actinobacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
HFD2_k127_5669868_21	1229780.BN381_350132	3.906e-34	141.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_5669868_12	28444.JODQ01000007_gene5885	8.632e-96	324.0	COG3491@1|root,COG3491@2|Bacteria,2GT52@201174|Actinobacteria,4EKPD@85012|Streptosporangiales	201174|Actinobacteria	C	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HFD2_k127_5669868_19	751945.Theos_1557	1.025e-44	171.0	COG3375@1|root,COG3375@2|Bacteria,1WI6K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	carboxylic acid catabolic process	-	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HFD2_k127_5669868_8	869210.Marky_0024	4.033e-124	407.0	COG4948@1|root,COG4948@2|Bacteria,1WJ5W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_5669868_0	1313172.YM304_22210	4.543e-253	795.0	COG0511@1|root,COG4799@1|root,COG0511@2|Bacteria,COG4799@2|Bacteria,2I46V@201174|Actinobacteria	201174|Actinobacteria	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,Carboxyl_trans
HFD2_k127_5669868_5	1068980.ARVW01000001_gene1331	1.678e-138	448.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4DY4T@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5669868_14	1380394.JADL01000002_gene1727	1.028e-87	298.0	COG0491@1|root,COG0491@2|Bacteria,1N6PM@1224|Proteobacteria,2TRZ4@28211|Alphaproteobacteria,2JVS0@204441|Rhodospirillales	204441|Rhodospirillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5669868_1	1313172.YM304_27390	4.572e-193	608.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5669868_9	1116369.KB890024_gene2663	1.594e-119	392.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,43GPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HFD2_k127_5669868_2	1155718.KB891896_gene2286	7.254e-193	622.0	COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria	201174|Actinobacteria	P	Flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase
HFD2_k127_5669868_7	1313172.YM304_34430	1.4e-124	417.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4CP5N@84992|Acidimicrobiia	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_5669868_3	1089455.MOPEL_027_00150	4.208e-163	523.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F7NZ@85018|Dermatophilaceae	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_5669868_16	479431.Namu_0655	2.109e-79	278.0	COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,4EVS1@85013|Frankiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD2_k127_5669868_4	1304878.AUGD01000011_gene4871	7.765e-143	465.0	COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,3JV1F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_42420	-	1.14.13.218	ko:K20940	ko00405,ko01130,map00405,map01130	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HFD2_k127_5669868_18	479435.Kfla_0721	1.253e-70	254.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4DNRJ@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_5669868_10	1386089.N865_03650	4.224e-117	383.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FIR9@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_5669868_17	1122611.KB903963_gene4892	7.186e-75	260.0	COG3186@1|root,COG3186@2|Bacteria,2GKCB@201174|Actinobacteria,4EIH7@85012|Streptosporangiales	201174|Actinobacteria	E	Biopterin-dependent aromatic amino acid hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HFD2_k127_5669868_22	1245475.ANAE01000177_gene969	8.615e-32	130.0	COG1522@1|root,COG1522@2|Bacteria,2HVG9@201174|Actinobacteria,4EK3U@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_5669868_27	711393.AYRX01000112_gene5665	2.817e-18	94.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria	201174|Actinobacteria	C	CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_5669868_29	1122951.ATUE01000005_gene1731	2.996e-15	82.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
HFD2_k127_5669868_31	525368.HMPREF0591_4965	0.0003273	52.0	2B4FQ@1|root,31X7C@2|Bacteria,2GYJ1@201174|Actinobacteria,23C55@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5669868_15	1123073.KB899241_gene2886	2.124e-87	300.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
HFD2_k127_5669868_30	1122611.KB903946_gene778	9.759e-11	68.0	2E5KE@1|root,330BK@2|Bacteria,2IKV9@201174|Actinobacteria,4EKJG@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5669868_13	1265310.CCBD010000043_gene2223	9.276e-91	305.0	COG2267@1|root,COG2267@2|Bacteria,2I8UI@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_5669868_24	1122611.KB903956_gene119	3.258e-25	108.0	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_24,MarR_2
HFD2_k127_5669868_20	1463936.JOJI01000021_gene421	5.318e-40	154.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_5669868_23	1313172.YM304_21760	2.442e-25	107.0	COG1314@1|root,COG1314@2|Bacteria,2HGDT@201174|Actinobacteria,4CNCC@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HFD2_k127_5669868_6	40571.JOEA01000024_gene7308	1.011e-128	417.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DXRP@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_5786067_5	1394178.AWOO02000005_gene3498	5.252e-120	398.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5786067_2	1123024.AUII01000009_gene1953	1.056e-160	512.0	COG0388@1|root,COG0388@2|Bacteria,2HW1E@201174|Actinobacteria,4EAGX@85010|Pseudonocardiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD2_k127_5786067_11	247156.NFA_23910	4.617e-06	50.0	COG0859@1|root,COG0859@2|Bacteria,2GMZG@201174|Actinobacteria,4FXEF@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_5786067_12	1134445.AJJM01000062_gene1640	0.0003644	52.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria	201174|Actinobacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HFD2_k127_5786067_10	882086.SacxiDRAFT_0831	5.005e-17	82.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4E0TN@85010|Pseudonocardiales	201174|Actinobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD2_k127_5786067_9	882083.SacmaDRAFT_1537	2.941e-30	130.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4E0TN@85010|Pseudonocardiales	201174|Actinobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD2_k127_5786067_7	1229780.BN381_130053	1.436e-84	286.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HFD2_k127_5786067_1	351607.Acel_1699	2.237e-179	568.0	COG0535@1|root,COG0535@2|Bacteria,2HTDD@201174|Actinobacteria,4ES4M@85013|Frankiales	201174|Actinobacteria	F	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
HFD2_k127_5786067_3	882083.SacmaDRAFT_2677	6.64e-152	496.0	COG0761@1|root,COG0775@1|root,COG0761@2|Bacteria,COG0775@2|Bacteria,2GIZ7@201174|Actinobacteria,4DZDW@85010|Pseudonocardiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,PNP_UDP_1
HFD2_k127_5786067_0	351607.Acel_1697	1.05e-262	838.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4ES7V@85013|Frankiales	201174|Actinobacteria	I	Squalene--hopene cyclase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HFD2_k127_5786067_6	500153.JOEK01000009_gene5015	5.226e-87	299.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hopB	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_5786067_4	1123320.KB889697_gene9001	2.765e-135	451.0	COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria	201174|Actinobacteria	H	squalene-associated FAD-dependent desaturase	hopC	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_5786067_8	1137271.AZUM01000001_gene1401	2.961e-39	150.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4E0VU@85010|Pseudonocardiales	201174|Actinobacteria	I	Squalene phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_5795115_6	1313172.YM304_20100	5.062e-133	438.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria	201174|Actinobacteria	G	xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_5795115_24	1463921.JODF01000005_gene6202	3.189e-50	190.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria	201174|Actinobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD2_k127_5795115_21	1463861.JNXE01000004_gene1924	9.097e-71	257.0	COG0665@1|root,COG0665@2|Bacteria,2GMR7@201174|Actinobacteria	201174|Actinobacteria	E	D-amino acid	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_5795115_12	1040983.AXAE01000018_gene5911	6.373e-110	365.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2U1Z3@28211|Alphaproteobacteria,43J76@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Proline racemase	-	-	-	-	-	-	-	-	-	-	-	-	Pro_racemase
HFD2_k127_5795115_20	1007105.PT7_0370	3.399e-83	285.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2VRPR@28216|Betaproteobacteria,3T91J@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_5795115_28	644283.Micau_4908	5.362e-25	115.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4DDPM@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_5795115_9	469383.Cwoe_2182	8.598e-125	411.0	COG3665@1|root,COG3665@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
HFD2_k127_5795115_27	710696.Intca_1861	1.238e-39	153.0	2E6U3@1|root,331DV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
HFD2_k127_5795115_7	1071679.BG57_31120	9.771e-132	432.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,1K89F@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	menC	-	4.2.1.113,4.2.1.171,5.1.1.20	ko:K02549,ko:K19802,ko:K21624	ko00130,ko00330,ko01100,ko01110,map00130,map00330,map01100,map01110	M00116	R04031,R10938,R11625	RC01053,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_5795115_4	405948.SACE_3881	1.069e-144	468.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4DYMP@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_5795115_8	436229.JOEH01000013_gene5862	5.404e-125	412.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,2NH8Y@228398|Streptacidiphilus	201174|Actinobacteria	E	Arginase family	gbh	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_5795115_16	1306174.JODP01000013_gene7452	9.073e-100	336.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_5795115_15	1121946.AUAX01000024_gene7585	1.076e-100	335.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DA7P@85008|Micromonosporales	201174|Actinobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_5795115_14	1306174.JODP01000013_gene7454	1.29e-106	365.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_5795115_13	1121946.AUAX01000024_gene7587	8.317e-107	357.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4D95X@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_5795115_5	1306174.JODP01000013_gene7456	1.694e-137	451.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_5795115_19	1121946.AUAX01000008_gene7312	1.248e-84	310.0	COG1129@1|root,COG1129@2|Bacteria,2I2G1@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter, ATP-binding protein	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HFD2_k127_5795115_29	1306174.JODP01000007_gene2511	1.027e-06	55.0	COG5516@1|root,COG5516@2|Bacteria,2GRF7@201174|Actinobacteria	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HFD2_k127_5795115_23	1313172.YM304_24730	1.282e-55	207.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4CN5J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HFD2_k127_5795115_26	644283.Micau_1683	5.595e-42	169.0	COG1309@1|root,COG1309@2|Bacteria,2GP3D@201174|Actinobacteria,4DD5T@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HFD2_k127_5795115_2	1313172.YM304_24680	2.51e-160	513.0	COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria	201174|Actinobacteria	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_5795115_10	1313172.YM304_24440	5.446e-117	387.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_5795115_17	1313172.YM304_24400	6.86e-90	303.0	COG2188@1|root,COG2188@2|Bacteria,2HF8W@201174|Actinobacteria,4CN6C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HFD2_k127_5795115_0	1313172.YM304_24390	0.0	1146.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4CMQB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HFD2_k127_5795115_22	298655.KI912266_gene4994	2.669e-63	223.0	COG0778@1|root,COG0778@2|Bacteria,2GKG5@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_5795115_25	1463901.JOIY01000018_gene6592	2.215e-46	187.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_5795115_1	1313172.YM304_21270	7.776e-191	607.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	2.3.1.51,3.1.3.3	ko:K15781	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,HAD
HFD2_k127_5795115_11	1313172.YM304_21260	1.427e-112	372.0	COG0583@1|root,COG0583@2|Bacteria,2HF8Y@201174|Actinobacteria,4CN2C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5795115_3	1313172.YM304_21250	1.927e-151	497.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMQK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD2_k127_5801526_27	1313172.YM304_21410	2.443e-22	98.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CMW4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S1-like RNA-binding domain	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_5801526_15	1313172.YM304_21390	5.625e-91	306.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Methyltransf_25,Methyltransf_31
HFD2_k127_5801526_0	1229780.BN381_80407	1.312e-310	975.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,3UWEE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD2_k127_5801526_16	1313172.YM304_21370	1.326e-90	301.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4CN3I@84992|Acidimicrobiia	84992|Acidimicrobiia	T	ANTAR	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HFD2_k127_5801526_29	1313172.YM304_21360	1.615e-17	91.0	29B43@1|root,2ZY2Q@2|Bacteria,2HD3P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5801526_24	450851.PHZ_c3035	1.081e-31	133.0	COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,2U9EH@28211|Alphaproteobacteria,2KIZV@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HFD2_k127_5801526_22	762376.AXYL_00024	2.811e-55	198.0	COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,2W2TG@28216|Betaproteobacteria,3T7QY@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant	-	-	4.2.1.108	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06979	RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Ectoine_synth
HFD2_k127_5801526_4	1313172.YM304_21340	9.472e-199	624.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4CMPZ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HFD2_k127_5801526_8	1313172.YM304_21330	7.578e-133	430.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4CMQV@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD2_k127_5801526_12	1313172.YM304_21320	1.279e-96	336.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4CN06@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_5801526_25	1313172.YM304_21310	3.777e-29	118.0	COG0236@1|root,COG0236@2|Bacteria,2HGA0@201174|Actinobacteria,4CN8U@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD2_k127_5801526_9	525909.Afer_1089	3.532e-121	416.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4CMVV@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD2_k127_5801526_28	1313172.YM304_23900	1.35e-21	110.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	desA	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HFD2_k127_5801526_21	1313172.YM304_21280	2.739e-55	202.0	COG0764@1|root,COG0764@2|Bacteria,2GQWT@201174|Actinobacteria,4CN5K@84992|Acidimicrobiia	84992|Acidimicrobiia	I	FabA-like domain	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HFD2_k127_5801526_20	1313172.YM304_17780	1.118e-60	212.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4CN8N@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_5801526_10	1313172.YM304_24320	1.111e-112	375.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4CMZW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HFD2_k127_5801526_5	1313172.YM304_24310	4.17e-198	622.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4CMR9@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_5801526_14	1313172.YM304_24300	3.459e-92	308.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4CN2A@84992|Acidimicrobiia	84992|Acidimicrobiia	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HFD2_k127_5801526_18	1313172.YM304_24270	4.6e-81	276.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4CN2P@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HFD2_k127_5801526_11	1229780.BN381_130130	2.257e-103	353.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,3UWB0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_5801526_26	656024.FsymDg_0257	8.988e-24	106.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4ET3M@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_5801526_3	1313172.YM304_24260	1.4e-236	736.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4CMWI@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HFD2_k127_5801526_17	1313172.YM304_24220	7.784e-82	287.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CN8K@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HFD2_k127_5801526_23	1313172.YM304_24210	5.792e-38	149.0	COG0020@1|root,COG0020@2|Bacteria	2|Bacteria	I	transferase activity, transferring alkyl or aryl (other than methyl) groups	MA20_23565	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD2_k127_5801526_13	1313172.YM304_24200	2.033e-95	330.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CN13@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD2_k127_5801526_2	1313172.YM304_24190	4.702e-244	770.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria	201174|Actinobacteria	KL	helicase	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HFD2_k127_5801526_19	1313172.YM304_24150	4.668e-77	265.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4CNYM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_5801526_1	350054.Mflv_4613	8.409e-247	788.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,23802@1762|Mycobacteriaceae	201174|Actinobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD2_k127_5801526_6	1068980.ARVW01000001_gene6807	3.432e-186	601.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DZTM@85010|Pseudonocardiales	201174|Actinobacteria	I	Acetyl propionyl-CoA carboxylase, alpha subunit	accA2	-	6.4.1.1,6.4.1.3,6.4.1.4	ko:K01959,ko:K01965,ko:K01968	ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230	M00036,M00173,M00373,M00620,M00741	R00344,R01859,R04138	RC00040,RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0973c	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HFD2_k127_5801526_7	675635.Psed_1610	3.657e-155	506.0	COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4DX6T@85010|Pseudonocardiales	201174|Actinobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HFD2_k127_5885453_6	1341646.CBMO010000140_gene2615	2.823e-26	110.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,232YZ@1762|Mycobacteriaceae	201174|Actinobacteria	G	PFAM Xylose	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_5885453_3	1122939.ATUD01000006_gene1727	1.682e-97	329.0	COG1609@1|root,COG1609@2|Bacteria,2GK1X@201174|Actinobacteria,4CR46@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
HFD2_k127_5885453_1	1313172.YM304_19170	1.401e-125	413.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4CNH1@84992|Acidimicrobiia	201174|Actinobacteria	G	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD2_k127_5885453_4	1313172.YM304_19160	3.606e-62	216.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4CN9D@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HFD2_k127_5885453_7	1313172.YM304_19150	2.107e-21	106.0	28Z2K@1|root,2ZKV3@2|Bacteria,2HA4X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5885453_0	1313172.YM304_19140	3.211e-166	530.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4CN28@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_5885453_2	1313172.YM304_19130	7.455e-117	386.0	COG1600@1|root,COG1600@2|Bacteria,2HGVB@201174|Actinobacteria,4CNW5@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
HFD2_k127_5885453_8	1068980.ARVW01000001_gene5522	8.774e-06	50.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria,4E7HS@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5885453_5	1229780.BN381_170028	1.111e-35	144.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
HFD2_k127_5886880_4	1380394.JADL01000004_gene6008	1.942e-51	201.0	COG0824@1|root,COG1250@1|root,COG0824@2|Bacteria,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,2JQTT@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,4HBT_2
HFD2_k127_5886880_0	67267.JNXT01000036_gene3205	2.197e-192	604.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD2_k127_5886880_1	1380394.JADL01000004_gene6007	2.935e-136	452.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2JQGU@204441|Rhodospirillales	204441|Rhodospirillales	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HFD2_k127_5886880_3	247633.GP2143_05550	2.52e-61	233.0	COG1028@1|root,COG1028@2|Bacteria,1MX30@1224|Proteobacteria,1S4D9@1236|Gammaproteobacteria,1JBTS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_5886880_2	43354.JOIJ01000002_gene4330	7.002e-99	343.0	COG0747@1|root,COG0747@2|Bacteria,2GK4Y@201174|Actinobacteria,4DZ0Y@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type dipeptide transport system	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_5916291_2	1120948.KB903243_gene2400	1.491e-230	734.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_5916291_22	675635.Psed_4327	4.409e-77	267.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_5916291_3	981369.JQMJ01000004_gene4964	1.103e-207	657.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,2NKD9@228398|Streptacidiphilus	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
HFD2_k127_5916291_33	1394178.AWOO02000030_gene4714	1.396e-34	138.0	COG1846@1|root,COG1846@2|Bacteria,2GQ94@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator (MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_5916291_9	204669.Acid345_2950	4.474e-130	437.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,3Y2I6@57723|Acidobacteria,2JHKP@204432|Acidobacteriia	204432|Acidobacteriia	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
HFD2_k127_5916291_40	1144275.COCOR_03122	1.185e-23	104.0	COG3832@1|root,COG5646@1|root,COG3832@2|Bacteria,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF1801
HFD2_k127_5916291_32	1035308.AQYY01000001_gene2786	3.349e-43	176.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_5916291_20	680198.SCAB_63371	1.22e-78	277.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria	201174|Actinobacteria	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_5916291_23	471852.Tcur_4060	4.941e-75	263.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4EG1Y@85012|Streptosporangiales	201174|Actinobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD2_k127_5916291_45	402626.Rpic_0069	1.955e-10	71.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2VT7Y@28216|Betaproteobacteria,1KH80@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_5916291_28	1146883.BLASA_1707	2.05e-48	183.0	COG0596@1|root,COG0596@2|Bacteria,2I2QI@201174|Actinobacteria	201174|Actinobacteria	S	hydrolases or acyltransferases alpha beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_5916291_11	1035308.AQYY01000001_gene1342	7.864e-127	420.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,260WD@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM NRAMP (natural resistance-associated macrophage protein) metal ion transporters	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD2_k127_5916291_31	298654.FraEuI1c_3933	1.021e-45	173.0	COG4591@1|root,COG4591@2|Bacteria,2I445@201174|Actinobacteria	201174|Actinobacteria	M	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HFD2_k127_5916291_26	35754.JNYJ01000024_gene9066	7.471e-56	214.0	COG4591@1|root,COG4591@2|Bacteria,2I445@201174|Actinobacteria,4DMJ9@85008|Micromonosporales	201174|Actinobacteria	M	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HFD2_k127_5916291_36	1048339.KB913029_gene4679	2.38e-30	127.0	COG1695@1|root,COG1695@2|Bacteria,2GWBH@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10917	ko02024,ko05111,map02024,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	PadR
HFD2_k127_5916291_25	1150399.AQYK01000001_gene1450	3.005e-61	220.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4FNG8@85023|Microbacteriaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD2_k127_5916291_19	1120960.ATXG01000011_gene3561	2.489e-81	298.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,4FQMK@85023|Microbacteriaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
HFD2_k127_5916291_35	1463825.JNXC01000037_gene3510	1.845e-31	143.0	COG2208@1|root,COG2208@2|Bacteria,2GKUC@201174|Actinobacteria,4DZHM@85010|Pseudonocardiales	201174|Actinobacteria	KT	Stage II sporulation protein E (SpoIIE)	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_4,PAS_9,SpoIIE
HFD2_k127_5916291_37	66377.JOBH01000006_gene65	3.604e-30	128.0	COG5592@1|root,COG5592@2|Bacteria,2GNJ6@201174|Actinobacteria	201174|Actinobacteria	S	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_5916291_17	1110697.NCAST_32_07510	3.147e-95	331.0	COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4FZ9I@85025|Nocardiaceae	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
HFD2_k127_5916291_7	1127134.NOCYR_2575	4.098e-158	508.0	COG1960@1|root,COG1960@2|Bacteria,2HGF7@201174|Actinobacteria,4FWGE@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_5916291_29	479431.Namu_4940	2.524e-47	173.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4ET2W@85013|Frankiales	201174|Actinobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_5916291_14	1121377.KB906405_gene135	2.356e-109	375.0	COG0809@1|root,COG0809@2|Bacteria,1WJW8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	-	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_5916291_21	1246995.AFR_16780	2.06e-78	269.0	COG1028@1|root,COG1028@2|Bacteria,2HGA2@201174|Actinobacteria,4DCYR@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_5916291_30	101510.RHA1_ro00076	4.596e-46	171.0	2CH5R@1|root,32S5B@2|Bacteria,2IQUR@201174|Actinobacteria,4G2Y9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HFD2_k127_5916291_34	1229780.BN381_310034	1.216e-32	128.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,3UWGU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HFD2_k127_5916291_18	1229780.BN381_310034	9.095e-90	315.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,3UWGU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HFD2_k127_5916291_15	994479.GL877878_gene1428	1.003e-102	341.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,4E28A@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5916291_24	469383.Cwoe_3822	4.032e-66	228.0	COG2128@1|root,COG2128@2|Bacteria,2IFER@201174|Actinobacteria,4CU3Q@84995|Rubrobacteria	84995|Rubrobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_5916291_5	208439.AJAP_03665	1.318e-180	577.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DXBU@85010|Pseudonocardiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD2_k127_5916291_39	710686.Mycsm_02860	6.145e-25	118.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,Guanylate_cyc,NB-ARC
HFD2_k127_5916291_46	1380390.JIAT01000010_gene4630	1.01e-07	61.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4CPDK@84995|Rubrobacteria	84995|Rubrobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
HFD2_k127_5916291_0	426117.M446_3866	0.0	1210.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,1JZ2F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase central domain	sardh	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_5916291_1	1380391.JIAS01000014_gene2047	7.326e-283	892.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JRC3@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_5916291_16	1432055.GLUCORHAEAF1_13950	2.073e-97	325.0	COG0500@1|root,COG2226@2|Bacteria,1MV7N@1224|Proteobacteria,2TVGZ@28211|Alphaproteobacteria,2JR6U@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_5916291_8	1211815.CBYP010000063_gene1856	1.113e-149	496.0	2BYTM@1|root,30H85@2|Bacteria,2I87C@201174|Actinobacteria,4EW2I@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5916291_10	1211815.CBYP010000063_gene1857	4.551e-130	425.0	COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria,4EXAK@85013|Frankiales	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
HFD2_k127_5916291_42	469383.Cwoe_5214	1.102e-12	75.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	MA20_25230	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HFD2_k127_5916291_38	1108045.GORHZ_138_00020	2.121e-28	124.0	COG3255@1|root,COG3255@2|Bacteria,2GJ5N@201174|Actinobacteria,4GAWJ@85026|Gordoniaceae	201174|Actinobacteria	I	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,SCP2
HFD2_k127_5916291_44	666685.R2APBS1_0501	8.949e-11	70.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,1RTBU@1236|Gammaproteobacteria,1X7JZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5916291_43	1121403.AUCV01000028_gene2421	1.642e-12	75.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria,2MNWA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5916291_13	479434.Sthe_0078	5.831e-120	406.0	COG0477@1|root,COG0477@2|Bacteria,2G89T@200795|Chloroflexi,27Y75@189775|Thermomicrobia	189775|Thermomicrobia	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5916291_4	1449347.JQLN01000004_gene6475	3.087e-190	625.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,2M0PM@2063|Kitasatospora	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_5916291_47	63737.Npun_R3697	1.519e-06	57.0	COG2885@1|root,COG2885@2|Bacteria,1GQCT@1117|Cyanobacteria,1HSHB@1161|Nostocales	2|Bacteria	M	Domain of unknown function (DUF4157)	-	-	-	ko:K02689,ko:K02690	ko00195,ko01100,map00195,map01100	M00163	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	DUF4157,OmpA,PsaA_PsaB
HFD2_k127_5916291_27	298655.KI912266_gene3506	1.398e-49	186.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria,4ESF4@85013|Frankiales	201174|Actinobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_5916291_6	1122222.AXWR01000003_gene1420	5.215e-177	571.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	-	ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3	-	-	Arylsulfotran_2,UnbV_ASPIC,VCBS
HFD2_k127_5916291_12	1432050.IE4771_CH03440	5.209e-121	407.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,4B9MP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
HFD2_k127_6007214_9	543632.JOJL01000008_gene5896	3.944e-46	181.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4D8Q0@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_6007214_3	266835.14023081	1.869e-119	407.0	COG2041@1|root,COG2041@2|Bacteria,1NR5V@1224|Proteobacteria,2UQ6F@28211|Alphaproteobacteria,43R8Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD2_k127_6007214_7	1035308.AQYY01000002_gene237	1.487e-48	184.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF2156,Rhomboid
HFD2_k127_6007214_2	1313172.YM304_21600	2.908e-135	442.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_6007214_0	1313172.YM304_21580	0.0	1612.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CMUS@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_6007214_10	380358.XALC_0992	2.413e-44	186.0	COG2972@1|root,COG5001@1|root,COG2972@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X2Z4@135614|Xanthomonadales	135614|Xanthomonadales	T	phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,dCache_3
HFD2_k127_6007214_1	1313172.YM304_21490	0.0	1092.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4CMWE@84992|Acidimicrobiia	84992|Acidimicrobiia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD2_k127_6007214_6	2074.JNYD01000003_gene3597	3.787e-54	203.0	COG1414@1|root,COG1414@2|Bacteria,2GJAZ@201174|Actinobacteria,4E8Z7@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_6007214_4	1217718.ALOU01000021_gene2389	4.698e-95	323.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2VIJB@28216|Betaproteobacteria,1K69D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_6007214_5	1122929.KB908231_gene3613	7.66e-72	254.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protocatechuate 3,4-dioxygenase, beta subunit'	-	-	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
HFD2_k127_6007214_8	1380394.JADL01000001_gene2219	2.064e-46	180.0	COG2514@1|root,COG2514@2|Bacteria,1PNKQ@1224|Proteobacteria,2VAA8@28211|Alphaproteobacteria,2JY35@204441|Rhodospirillales	204441|Rhodospirillales	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_6007214_11	402881.Plav_1785	1.152e-26	111.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,1JQ3T@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
HFD2_k127_6031502_6	675635.Psed_2525	2.286e-48	183.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4E1GT@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_6031502_9	497321.C664_06433	1.266e-05	56.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,2KWI4@206389|Rhodocyclales	206389|Rhodocyclales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_6031502_2	62928.azo1853	2.526e-92	310.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VH5E@28216|Betaproteobacteria,2KXZ7@206389|Rhodocyclales	206389|Rhodocyclales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.132,4.2.1.80	ko:K18364	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02601,R05864	RC00750,RC02676	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_6031502_3	1158292.JPOE01000002_gene2219	3.566e-84	287.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VH5Y@28216|Betaproteobacteria,1KJHH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	dmpH	-	4.1.1.77	ko:K01617	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02602,R05374	RC00751,RC02672	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_6031502_7	40571.JOEA01000004_gene6324	1.034e-34	148.0	2DMXW@1|root,32UAS@2|Bacteria,2IFZ0@201174|Actinobacteria,4E3Q0@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6031502_8	266265.Bxe_C1001	8.847e-31	134.0	COG0346@1|root,COG0346@2|Bacteria,1QURX@1224|Proteobacteria,2WG5A@28216|Betaproteobacteria,1KI9Y@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_6031502_4	653045.Strvi_6126	4.459e-68	246.0	COG2070@1|root,COG2070@2|Bacteria,2IN9Q@201174|Actinobacteria	201174|Actinobacteria	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HFD2_k127_6031502_5	1133850.SHJG_0752	5.812e-58	208.0	2DM93@1|root,327FJ@2|Bacteria,2I2JP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_6031502_0	68570.DC74_7439	4.825e-126	409.0	COG4569@1|root,COG4569@2|Bacteria,2GKBZ@201174|Actinobacteria	201174|Actinobacteria	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	-	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
HFD2_k127_6031502_1	337191.KTR9_0812	1.234e-120	394.0	COG0119@1|root,COG0119@2|Bacteria,2GJBI@201174|Actinobacteria,4GAZC@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds	hsaF	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
HFD2_k127_6049142_5	644966.Tmar_1638	4.474e-98	342.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD2_k127_6049142_3	1229780.BN381_170035	1.005e-138	479.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_6049142_0	1229780.BN381_170034	1.708e-186	606.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,3UWFB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HFD2_k127_6049142_10	1229780.BN381_170009	5.799e-32	131.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,3UWZ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ferric uptake regulator family	catR	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_6049142_6	1121033.AUCF01000003_gene3281	2.461e-65	233.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2U5EA@28211|Alphaproteobacteria,2JRP1@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1592 Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HFD2_k127_6049142_2	1121877.JQKF01000010_gene732	1.54e-142	467.0	COG0247@1|root,COG0247@2|Bacteria,2HGN8@201174|Actinobacteria,4CNP8@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HFD2_k127_6049142_9	1229780.BN381_170007	3.74e-52	199.0	COG0247@1|root,COG0247@2|Bacteria,2GVNV@201174|Actinobacteria	201174|Actinobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HFD2_k127_6049142_11	1313172.YM304_19060	6.593e-27	111.0	2CC1Y@1|root,32YV9@2|Bacteria	2|Bacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HFD2_k127_6049142_4	1313172.YM304_19070	2.575e-125	410.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4CN1D@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_6049142_7	1313172.YM304_19080	3.032e-63	229.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4CNCE@84992|Acidimicrobiia	84992|Acidimicrobiia	E	GHMP kinases N terminal domain	-	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_6049142_1	1313172.YM304_19090	6.585e-180	579.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4CN4W@84992|Acidimicrobiia	84992|Acidimicrobiia	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_6049142_8	1313172.YM304_19100	1.13e-59	223.0	COG3688@1|root,COG3688@2|Bacteria,2GR19@201174|Actinobacteria	201174|Actinobacteria	M	RNA-binding protein containing a PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
HFD2_k127_6053922_0	1121272.KB903250_gene2734	2.848e-206	649.0	COG1260@1|root,COG1260@2|Bacteria,2GJVN@201174|Actinobacteria	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HFD2_k127_6053922_2	105425.BBPL01000005_gene7951	8.254e-54	206.0	COG0642@1|root,COG2205@2|Bacteria,2H2N3@201174|Actinobacteria,2NF89@228398|Streptacidiphilus	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	prrB	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019538,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07655	ko02020,map02020	M00462	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_6053922_1	258533.BN977_03300	2.039e-62	218.0	COG0745@1|root,COG0745@2|Bacteria,2IAN7@201174|Actinobacteria,235BQ@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_6155144_0	28444.JODQ01000001_gene2611	1.943e-138	484.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
HFD2_k127_6155144_1	1242864.D187_001638	4.142e-07	59.0	COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.13.3	ko:K02486	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase,Response_reg
HFD2_k127_6164925_0	525909.Afer_0543	4.541e-212	664.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD2_k127_6164925_11	222534.KB893750_gene4300	0.0002776	49.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria,4EWSN@85013|Frankiales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HFD2_k127_6164925_8	1313172.YM304_14750	2.166e-42	159.0	2FF8Q@1|root,3476J@2|Bacteria,2H7PN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6164925_7	525904.Tter_1697	5.006e-54	204.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
HFD2_k127_6164925_10	1121924.ATWH01000006_gene1788	5.105e-24	116.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4FP2S@85023|Microbacteriaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HFD2_k127_6164925_4	279010.BL02166	1.398e-71	251.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,4HAD9@91061|Bacilli,1ZAW4@1386|Bacillus	91061|Bacilli	O	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HFD2_k127_6164925_9	1306174.JODP01000003_gene1783	8.221e-41	157.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
HFD2_k127_6164925_5	1313172.YM304_14780	2.134e-62	218.0	COG2606@1|root,COG2606@2|Bacteria,2HH14@201174|Actinobacteria,4CP1D@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HFD2_k127_6164925_6	1313172.YM304_14810	1.922e-59	209.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4CN20@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_6164925_1	1313172.YM304_14820	1.246e-200	632.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CMVJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HFD2_k127_6164925_2	525909.Afer_0566	5.473e-94	315.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4CMZ6@84992|Acidimicrobiia	84992|Acidimicrobiia	O	FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HFD2_k127_6164925_3	1229780.BN381_30040	2.276e-87	295.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	MA20_28095	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HFD2_k127_6169548_6	1267533.KB906734_gene4035	2.402e-09	71.0	COG4409@1|root,COG4409@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF1573
HFD2_k127_6169548_5	1197706.AKKK01000058_gene1444	2.512e-19	104.0	COG0823@1|root,COG1404@1|root,COG4733@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG4733@2|Bacteria,2IC0F@201174|Actinobacteria	201174|Actinobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,SLH
HFD2_k127_6169548_1	1120934.KB894405_gene5281	3.973e-76	275.0	COG1470@1|root,COG1470@2|Bacteria,2H4ZH@201174|Actinobacteria,4E24A@85010|Pseudonocardiales	201174|Actinobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD2_k127_6169548_2	1032480.MLP_03820	2.651e-65	231.0	COG2197@1|root,COG2197@2|Bacteria,2GNUE@201174|Actinobacteria,4DUAX@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_6169548_4	1303692.SFUL_5306	1.487e-19	104.0	28RC2@1|root,2ZDRH@2|Bacteria,2GNI9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
HFD2_k127_6169548_0	345341.KUTG_07888	1.613e-243	761.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4E0BB@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HFD2_k127_6169548_3	1120934.KB894405_gene5266	7.582e-53	189.0	2ACY3@1|root,312JQ@2|Bacteria	2|Bacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HFD2_k127_6169548_7	797302.Halru_2688	0.0001273	45.0	arCOG11412@1|root,arCOG11412@2157|Archaea,2XX5Z@28890|Euryarchaeota,23VV6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6170408_2	1205680.CAKO01000029_gene5281	4.382e-238	747.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2JPT6@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_6170408_12	390989.JOEG01000001_gene4913	1.914e-44	183.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4D93G@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
HFD2_k127_6170408_14	526225.Gobs_3702	1.275e-23	110.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_6170408_15	269796.Rru_A1938	1.196e-09	68.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,2JQRQ@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HFD2_k127_6170408_1	1123487.KB892839_gene228	0.0	1235.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,2KUR9@206389|Rhodocyclales	1224|Proteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	cbpA	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
HFD2_k127_6170408_0	953739.SVEN_0529	0.0	1243.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria	201174|Actinobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HFD2_k127_6170408_8	926550.CLDAP_32510	9.264e-56	202.0	COG0735@1|root,COG0735@2|Bacteria,2G9HJ@200795|Chloroflexi	200795|Chloroflexi	P	Ferric uptake regulator family	-	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_6170408_6	1032480.MLP_25160	1.067e-76	273.0	COG2706@1|root,COG2706@2|Bacteria,2I6SW@201174|Actinobacteria,4DV1E@85009|Propionibacteriales	201174|Actinobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_6170408_10	330084.JNYZ01000005_gene882	1.815e-50	196.0	COG1231@1|root,COG1231@2|Bacteria	2|Bacteria	E	oxidoreductase activity	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_6170408_13	1121933.AUHH01000010_gene2520	2.64e-38	155.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Polyketide_cyc2
HFD2_k127_6170408_11	1157637.KB892114_gene4699	7.693e-50	185.0	COG1309@1|root,COG1309@2|Bacteria,2INX9@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_6170408_3	1211815.CBYP010000019_gene2879	1.654e-200	631.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	lldD1_1	-	1.13.12.4	ko:K00467	ko00620,map00620	-	R00319	RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_6170408_7	479431.Namu_0939	1.379e-65	230.0	COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria,4ESR4@85013|Frankiales	201174|Actinobacteria	L	PFAM Uracil-DNA glycosylase superfamily	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_6170408_5	684949.ATTJ01000001_gene1799	4.844e-80	274.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	yddR	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
HFD2_k127_6170408_4	1123023.JIAI01000001_gene6030	3.937e-114	387.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria,4E4MP@85010|Pseudonocardiales	201174|Actinobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HFD2_k127_6170408_9	1380394.JADL01000004_gene6042	8.127e-54	201.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TUTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6195210_9	1380390.JIAT01000010_gene4390	5.369e-19	94.0	COG2931@1|root,COG2931@2|Bacteria,2GYC8@201174|Actinobacteria	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
HFD2_k127_6195210_1	1123008.KB905703_gene547	0.0	1457.0	COG2351@1|root,COG2351@2|Bacteria,4NJ4W@976|Bacteroidetes	976|Bacteroidetes	M	Salmonella virulence plasmid 28.1kDa A protein	-	-	-	-	-	-	-	-	-	-	-	-	Hemopexin,VRP1
HFD2_k127_6195210_0	1123008.KB905703_gene546	0.0	1673.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2,LysM,PA14,PG_binding_1,Phage_lysozyme,VRP1
HFD2_k127_6195210_5	1229780.BN381_130292	2.065e-55	201.0	293RJ@1|root,2ZR76@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD2_k127_6195210_3	208444.JNYY01000001_gene5579	4.83e-57	207.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria,4E2MZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_6195210_8	1385518.N798_03240	4.687e-21	100.0	COG1734@1|root,COG1734@2|Bacteria,2IQP3@201174|Actinobacteria,4FHJN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD2_k127_6195210_12	1219581.HMPREF1628_06865	0.0004316	51.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,4D5J1@85005|Actinomycetales	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_6195210_11	861299.J421_1203	2.989e-08	65.0	2EKG6@1|root,33E67@2|Bacteria,1ZV0B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6195210_10	1313172.YM304_10330	3.311e-13	79.0	COG1361@1|root,COG1361@2|Bacteria,2I7KE@201174|Actinobacteria,4CNYF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
HFD2_k127_6195210_7	591159.ACEZ01000218_gene133	5.772e-30	141.0	COG5184@1|root,COG5184@2|Bacteria,2GISE@201174|Actinobacteria	201174|Actinobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6195210_4	382464.ABSI01000013_gene1571	1.341e-55	226.0	COG1572@1|root,COG3210@1|root,COG3386@1|root,COG4257@1|root,COG5373@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4257@2|Bacteria,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K13277,ko:K15125,ko:K15539	ko02024,ko05133,map02024,map05133	-	-	-	ko00000,ko00001,ko00536,ko01000,ko01002,ko03110	-	-	-	DUF5011
HFD2_k127_6195210_6	309801.trd_1922	5.753e-48	201.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,2GBSZ@200795|Chloroflexi,27ZA5@189775|Thermomicrobia	189775|Thermomicrobia	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6195210_2	1380390.JIAT01000013_gene145	1.163e-209	697.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
HFD2_k127_6323762_3	1313172.YM304_23520	1.509e-76	265.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_6323762_2	1313172.YM304_23510	5.212e-146	467.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CMT3@84992|Acidimicrobiia	84992|Acidimicrobiia	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HFD2_k127_6323762_0	1385520.N802_03220	8.618e-305	967.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4FE2Y@85021|Intrasporangiaceae	201174|Actinobacteria	O	PA domain	sbtB	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8
HFD2_k127_6323762_5	357808.RoseRS_1515	3.399e-20	97.0	2DRD4@1|root,33B9X@2|Bacteria,2G9Z1@200795|Chloroflexi,377FH@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6323762_4	1313172.YM304_23470	9.176e-37	147.0	2CIFA@1|root,348QY@2|Bacteria,2H88E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6323762_1	1313172.YM304_23460	1.798e-151	493.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CN0A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_6342763_4	298655.KI912266_gene4044	6.517e-58	209.0	COG1172@1|root,COG1172@2|Bacteria,2GMJW@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_6342763_0	1380390.JIAT01000012_gene2933	2.855e-135	450.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4CRF7@84995|Rubrobacteria	84995|Rubrobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HFD2_k127_6342763_3	298655.KI912266_gene4046	7.444e-80	281.0	COG1879@1|root,COG1879@2|Bacteria,2IBGG@201174|Actinobacteria	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_6342763_1	702113.PP1Y_Mpl6792	2.743e-103	350.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K3ZY@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_6342763_6	1172185.KB911513_gene4575	1.837e-48	193.0	COG3828@1|root,COG3828@2|Bacteria,2HJM9@201174|Actinobacteria,4G715@85025|Nocardiaceae	201174|Actinobacteria	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HFD2_k127_6342763_5	358823.DF19_12265	1.198e-49	192.0	COG1309@1|root,COG1309@2|Bacteria,2H9DW@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_6342763_7	1172185.KB911513_gene4577	3.337e-34	150.0	COG1309@1|root,COG1309@2|Bacteria,2IC94@201174|Actinobacteria,4G4E1@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_6342763_2	1968.JOEV01000036_gene1257	4.874e-82	277.0	COG2130@1|root,COG2130@2|Bacteria,2GKR8@201174|Actinobacteria	201174|Actinobacteria	S	NAD(P)-dependent	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HFD2_k127_6343479_18	446470.Snas_1823	2.188e-78	270.0	COG2086@1|root,COG2086@2|Bacteria,2IB9F@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_6343479_16	446470.Snas_1824	1.223e-82	286.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4EXSZ@85014|Glycomycetales	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	-	-	-	-	-	-	-	-	-	ETF,ETF_alpha
HFD2_k127_6343479_9	1121033.AUCF01000008_gene5678	4.337e-139	453.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,2TU0J@28211|Alphaproteobacteria,2JQ81@204441|Rhodospirillales	204441|Rhodospirillales	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD2_k127_6343479_15	1380391.JIAS01000015_gene370	2.006e-110	364.0	COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,2TRW6@28211|Alphaproteobacteria,2JT4Y@204441|Rhodospirillales	204441|Rhodospirillales	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6343479_2	1380391.JIAS01000015_gene369	0.0	1055.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_6343479_1	571166.KI421509_gene4196	0.0	1324.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_6343479_12	1003195.SCAT_3720	2.08e-125	410.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria	201174|Actinobacteria	E	glycine betaine	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
HFD2_k127_6343479_13	1155714.KB891987_gene2547	6.79e-121	424.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type proline glycine betaine transport system permease component	proW	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HFD2_k127_6343479_21	367299.JOEE01000012_gene3255	2.307e-66	241.0	COG2113@1|root,COG2113@2|Bacteria,2I2IV@201174|Actinobacteria,4FI22@85021|Intrasporangiaceae	201174|Actinobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HFD2_k127_6343479_3	2002.JOEQ01000044_gene830	3.007e-287	890.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4ENHD@85012|Streptosporangiales	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_6343479_25	1298863.AUEP01000009_gene60	6.317e-43	166.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4DQT3@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_6343479_10	1313172.YM304_33540	4.677e-130	422.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4CN0K@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_6343479_5	1123023.JIAI01000007_gene1962	4.342e-279	866.0	COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria,4DXJB@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HFD2_k127_6343479_22	69279.BG36_15765	8.185e-63	225.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,43PH7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_6343479_6	631454.N177_2983	1.046e-275	865.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQV0@28211|Alphaproteobacteria,1JQM8@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	stcD	-	1.3.1.34	ko:K00219,ko:K21833	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
HFD2_k127_6343479_23	1382356.JQMP01000001_gene844	6.681e-61	226.0	COG0265@1|root,COG0265@2|Bacteria,2G8RK@200795|Chloroflexi,27Y6G@189775|Thermomicrobia	189775|Thermomicrobia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_6343479_0	1035308.AQYY01000001_gene3422	0.0	1617.0	COG0737@1|root,COG1524@1|root,COG0737@2|Bacteria,COG1524@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,266SX@186807|Peptococcaceae	186801|Clostridia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,CW_binding_2,Metallophos,SLH
HFD2_k127_6343479_8	1032480.MLP_20320	4.901e-184	587.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4DP50@85009|Propionibacteriales	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD2_k127_6343479_7	69279.BG36_03370	2.541e-214	677.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TRAM@28211|Alphaproteobacteria,43IKT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HFD2_k127_6343479_4	1313172.YM304_26450	1.809e-280	882.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4CP5D@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_6343479_17	1380391.JIAS01000004_gene2985	7.133e-81	304.0	COG1173@1|root,COG1173@2|Bacteria,1R7UQ@1224|Proteobacteria,2U4Q2@28211|Alphaproteobacteria,2JV9K@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_6343479_19	1313172.YM304_26470	7.761e-76	266.0	COG0601@1|root,COG0601@2|Bacteria,2GJH7@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_6343479_11	1313172.YM304_26480	4.281e-129	433.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_6343479_27	272630.MexAM1_META1p4109	6.282e-10	72.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,1JVG2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Sarcosine oxidase delta subunit heterotetrameric	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
HFD2_k127_6343479_14	1123507.ATVQ01000001_gene1339	1.617e-110	375.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,1WA46@1268|Micrococcaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_6343479_20	1509405.GV67_12735	5.612e-72	269.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,4B810@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
HFD2_k127_6343479_26	1449976.KALB_6827	5.227e-27	119.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria,4E78N@85010|Pseudonocardiales	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_6343479_24	1207063.P24_10011	5.022e-43	168.0	COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2TQYY@28211|Alphaproteobacteria,2JRNC@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_6351970_9	996637.SGM_4568	6.836e-19	97.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
HFD2_k127_6351970_7	469383.Cwoe_4561	1.582e-28	124.0	2DPKA@1|root,332H3@2|Bacteria,2I2YH@201174|Actinobacteria,4CQ8H@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
HFD2_k127_6351970_0	1229780.BN381_10176	1.407e-165	530.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,3UW6R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_6351970_2	1313172.YM304_22060	4.461e-111	378.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4CNIW@84992|Acidimicrobiia	84992|Acidimicrobiia	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_6351970_1	1313172.YM304_14640	1.908e-127	415.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD2_k127_6351970_3	1313172.YM304_30260	5.31e-106	353.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	ycjY	GO:0008150,GO:0009987,GO:0051301	-	ko:K01990,ko:K06889	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	DLH,Hydrolase_4,Peptidase_S15
HFD2_k127_6351970_4	1440774.Y900_012615	4.369e-71	251.0	COG2761@1|root,COG2761@2|Bacteria,2H7YD@201174|Actinobacteria,2359N@1762|Mycobacteriaceae	201174|Actinobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_6351970_6	1077144.AGFF01000023_gene1383	1.29e-54	203.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HFD2_k127_6351970_5	1313172.YM304_30510	4.45e-55	196.0	296C4@1|root,2ZTMX@2|Bacteria,2HB9V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6351970_13	1313172.YM304_21590	9.986e-07	60.0	COG4719@1|root,COG4719@2|Bacteria,2H8R9@201174|Actinobacteria	2|Bacteria	S	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HFD2_k127_6351970_10	1123270.ATUR01000010_gene1903	9.604e-19	97.0	2EA9M@1|root,334E1@2|Bacteria,1ND0N@1224|Proteobacteria,2UIJ1@28211|Alphaproteobacteria,2K8CC@204457|Sphingomonadales	204457|Sphingomonadales	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HFD2_k127_6351970_8	1229780.BN381_210093	8.567e-26	106.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,3UXCB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_6360827_3	1287276.X752_28805	1.187e-112	377.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43HW8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_6360827_0	1313172.YM304_33670	6.264e-302	932.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_6360827_2	1206731.BAGB01000169_gene1549	1.075e-127	434.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4FU09@85025|Nocardiaceae	201174|Actinobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_6360827_1	269482.Bcep1808_3468	3.454e-133	437.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6360827_7	502025.Hoch_4464	7.392e-18	88.0	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
HFD2_k127_6360827_5	1194972.MVAC_19998	2.532e-28	127.0	2E6D0@1|root,3310N@2|Bacteria,2GQP8@201174|Actinobacteria,23A0E@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
HFD2_k127_6360827_4	1313172.YM304_33610	1.122e-54	205.0	COG1853@1|root,COG1853@2|Bacteria,2GPJS@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD2_k127_6360827_6	292459.STH1192	1.005e-25	113.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD2_k127_6360827_8	675635.Psed_5139	2.753e-05	52.0	291M6@1|root,2ZP7G@2|Bacteria,2GQKC@201174|Actinobacteria,4E75H@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6504788_16	1313172.YM304_38580	3.162e-78	266.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4CN0M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
HFD2_k127_6504788_21	1313172.YM304_38470	2.346e-55	205.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	1.3.1.34,3.1.2.6	ko:K00219,ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,Lactamase_B,Rhodanese
HFD2_k127_6504788_7	1313172.YM304_38460	2.487e-166	532.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HFD2_k127_6504788_23	1313172.YM304_38440	1.911e-44	165.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4CN53@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Iron-sulphur cluster biosynthesis	erpA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD2_k127_6504788_20	1313172.YM304_38430	6.342e-56	213.0	COG0526@1|root,COG0526@2|Bacteria,2HDQJ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6504788_27	1313172.YM304_38390	4.655e-33	141.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_6504788_5	247639.MGP2080_09848	1.023e-186	595.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HFD2_k127_6504788_3	1313172.YM304_38370	8.643e-228	711.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4CNCB@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_6504788_29	58344.JOEL01000033_gene2362	1.312e-31	134.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria	201174|Actinobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HFD2_k127_6504788_31	1219581.HMPREF1628_00925	4.643e-07	60.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4D3GR@85005|Actinomycetales	201174|Actinobacteria	I	Acyltransferase	yrhL	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_6504788_32	1961.JOAK01000001_gene3281	2.083e-05	57.0	COG0726@1|root,COG0726@2|Bacteria,2IBGP@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6504788_14	1313172.YM304_38350	2.226e-93	311.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_6504788_1	1313172.YM304_38340	7.274e-229	715.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CMV7@84992|Acidimicrobiia	84992|Acidimicrobiia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_6504788_10	1313172.YM304_38330	3.497e-147	472.0	COG0174@1|root,COG0174@2|Bacteria,2GKU9@201174|Actinobacteria,4CNKV@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Glutamine synthetase, catalytic domain	glnII	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_6504788_12	1131730.BAVI_09741	1.364e-119	394.0	COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,4HAB2@91061|Bacilli,1ZB55@1386|Bacillus	91061|Bacilli	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.20	ko:K00270	ko00350,ko00360,ko00400,ko01100,ko01110,ko01130,map00350,map00360,map00400,map01100,map01110,map01130	-	R00688,R09830	RC00006	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_6504788_17	251221.35214922	1.092e-64	230.0	COG1028@1|root,COG1028@2|Bacteria,1G47E@1117|Cyanobacteria	1117|Cyanobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_6504788_26	1304865.JAGF01000001_gene435	8.16e-35	145.0	2DPD0@1|root,331J4@2|Bacteria,2IFZU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6504788_4	1313172.YM304_38320	5.609e-204	663.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_2,Ig_3,PA14,PKD
HFD2_k127_6504788_0	1313172.YM304_38270	1.41e-279	868.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CMPV@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD2_k127_6504788_30	926550.CLDAP_34260	6.547e-28	128.0	COG0477@1|root,COG2814@2|Bacteria,2G96S@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_6504788_8	1313172.YM304_03200	8.305e-154	492.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HFD2_k127_6504788_28	1313172.YM304_03200	2.842e-32	138.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HFD2_k127_6504788_15	1313172.YM304_41160	4.769e-86	292.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_6504788_6	1146883.BLASA_0505	2.298e-166	528.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4ERE4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_6504788_25	1193181.BN10_540012	1.084e-37	147.0	COG1694@1|root,COG1694@2|Bacteria,2ISAF@201174|Actinobacteria,4FJCG@85021|Intrasporangiaceae	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
HFD2_k127_6504788_9	1229780.BN381_290013	2.127e-147	482.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	2|Bacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_6504788_18	981369.JQMJ01000004_gene4219	2.966e-62	226.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,2NF6S@228398|Streptacidiphilus	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_6504788_19	1120949.KB903327_gene5326	1.421e-61	241.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4DACW@85008|Micromonosporales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_6504788_22	1040986.ATYO01000025_gene1425	6.551e-50	201.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,43IIH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HFD2_k127_6504788_2	1137268.AZXF01000026_gene2438	4.784e-228	725.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4ER7C@85012|Streptosporangiales	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
HFD2_k127_6504788_11	1499967.BAYZ01000143_gene6121	5.611e-121	415.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_6504788_24	1122917.KB899675_gene243	1.152e-39	160.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HJTA@91061|Bacilli,26UF7@186822|Paenibacillaceae	91061|Bacilli	K	PFAM periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K03604,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD2_k127_6504788_13	392499.Swit_3100	2.662e-109	376.0	COG1520@1|root,COG1520@2|Bacteria,1R4I1@1224|Proteobacteria,2U05B@28211|Alphaproteobacteria,2K9NV@204457|Sphingomonadales	204457|Sphingomonadales	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6505017_19	697303.Thewi_0417	1.811e-07	53.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,42G50@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM LemA family protein	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD2_k127_6505017_4	1313172.YM304_19800	1.024e-145	466.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CNA7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD2_k127_6505017_16	1313172.YM304_19810	5.273e-45	185.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HFD2_k127_6505017_15	1313172.YM304_19810	1.129e-58	229.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HFD2_k127_6505017_3	1313172.YM304_19820	1.506e-160	509.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CMSX@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HFD2_k127_6505017_11	1313172.YM304_19830	8.521e-67	246.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4CN52@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HFD2_k127_6505017_9	1313172.YM304_19840	3.466e-99	329.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CMY7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD2_k127_6505017_10	1313172.YM304_19850	8.475e-68	235.0	COG1225@1|root,COG1225@2|Bacteria,2IJVV@201174|Actinobacteria,4CN6R@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_6505017_13	1313172.YM304_19860	7.524e-60	213.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CNAX@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD2_k127_6505017_17	1229780.BN381_50109	4.491e-43	172.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,3UWUJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HFD2_k127_6505017_2	1313172.YM304_19880	1.116e-160	522.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CMVN@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HFD2_k127_6505017_7	1122138.AQUZ01000016_gene176	5.101e-104	363.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4DNTR@85009|Propionibacteriales	201174|Actinobacteria	E	Amidinotransferase	ddaH	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
HFD2_k127_6505017_14	345341.KUTG_08085	8.089e-60	215.0	COG0412@1|root,COG0412@2|Bacteria,2IG4Y@201174|Actinobacteria,4E2ZB@85010|Pseudonocardiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_6505017_5	1313172.YM304_19900	1.48e-129	421.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4CMRE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_6505017_1	1313172.YM304_19910	1.239e-179	572.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CMQI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD2_k127_6505017_18	1313172.YM304_19920	6.789e-20	96.0	COG1862@1|root,COG1862@2|Bacteria,2GXK0@201174|Actinobacteria	201174|Actinobacteria	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD2_k127_6505017_6	1313172.YM304_19930	1.162e-111	380.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CMXX@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
HFD2_k127_6505017_8	1313172.YM304_19940	1.211e-103	362.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4CMYT@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD2_k127_6505017_12	1313172.YM304_19950	6.13e-66	229.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HFD2_k127_6505017_0	1313172.YM304_19960	0.0	1099.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_6535013_7	195522.BD01_1228	3.013e-112	375.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HFD2_k127_6535013_9	1125971.ASJB01000099_gene2295	1.548e-90	308.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4E972@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD2_k127_6535013_0	1313172.YM304_29400	0.0	1771.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMRZ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD2_k127_6535013_5	1313172.YM304_10270	3.926e-132	437.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_6535013_4	1313172.YM304_10260	1.679e-136	460.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
HFD2_k127_6535013_6	1313172.YM304_10250	6.809e-128	416.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
HFD2_k127_6535013_2	1313172.YM304_32480	1.763e-181	578.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CMW3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
HFD2_k127_6535013_1	1313172.YM304_36340	5.679e-186	597.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4CMY9@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase
HFD2_k127_6535013_10	1313172.YM304_29430	4.365e-80	274.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_6535013_13	1122609.AUGT01000003_gene2246	4.035e-06	51.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
HFD2_k127_6535013_3	1313172.YM304_29440	2.474e-149	489.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4CN9B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	-
HFD2_k127_6535013_8	1122132.AQYH01000005_gene656	1.245e-108	379.0	COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2TU3Y@28211|Alphaproteobacteria,4BAH8@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HFD2_k127_6535013_12	749927.AMED_7452	1.689e-25	115.0	COG4544@1|root,COG4544@2|Bacteria,2IIXE@201174|Actinobacteria,4E9QW@85010|Pseudonocardiales	201174|Actinobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6535013_11	1313172.YM304_29470	4.56e-35	138.0	2C1D9@1|root,2ZD16@2|Bacteria,2HBJG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6546436_13	1313172.YM304_22750	1.301e-16	80.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CMX0@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HFD2_k127_6546436_7	1313172.YM304_22740	1.267e-69	251.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50,Peptidase_M50B
HFD2_k127_6546436_5	326424.FRAAL6690	5.93e-85	305.0	COG1835@1|root,COG1835@2|Bacteria,2GMY0@201174|Actinobacteria,4ET71@85013|Frankiales	201174|Actinobacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6546436_9	1144275.COCOR_04546	2.686e-63	231.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Glyco_hydro_16
HFD2_k127_6546436_8	1313172.YM304_22730	5.065e-64	229.0	COG0354@1|root,COG0354@2|Bacteria,2HGHB@201174|Actinobacteria,4CNEP@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Aminomethyltransferase folate-binding domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
HFD2_k127_6546436_2	1313172.YM304_03720	2.5e-123	407.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria	201174|Actinobacteria	P	NhaP-type Na H and K H antiporters with a unique C-terminal domain	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
HFD2_k127_6546436_0	1313172.YM304_22710	3.039e-248	780.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4CMW2@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HFD2_k127_6546436_10	1313172.YM304_22700	4.146e-49	178.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4CN95@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HFD2_k127_6546436_11	1313172.YM304_22690	1.208e-43	162.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4CN9G@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD2_k127_6546436_1	926550.CLDAP_06320	1.972e-144	464.0	COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_6546436_3	1229780.BN381_80370	2.453e-113	381.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,3UWG7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HFD2_k127_6546436_4	1313172.YM304_22640	4.756e-92	313.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4CNA5@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HFD2_k127_6546436_6	1313172.YM304_22630	1.138e-80	278.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4CNA3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD2_k127_6546436_12	1313172.YM304_22620	2.667e-41	153.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CN2F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HFD2_k127_6597949_14	189753.AXAS01000069_gene8028	5.724e-05	46.0	COG3832@1|root,COG3832@2|Bacteria,1N3W1@1224|Proteobacteria,2TSB4@28211|Alphaproteobacteria,3JW46@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	MA20_35785	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_6597949_9	263358.VAB18032_18715	1.125e-48	177.0	COG0346@1|root,COG0346@2|Bacteria,2IIMV@201174|Actinobacteria,4DEC9@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,TetR_N
HFD2_k127_6597949_13	670487.Ocepr_0101	9.862e-10	64.0	COG2010@1|root,COG2010@2|Bacteria,1WIF2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_6597949_0	1278078.G419_03233	5.019e-214	679.0	COG0166@1|root,COG0166@2|Bacteria,2GJG0@201174|Actinobacteria,4FVB5@85025|Nocardiaceae	201174|Actinobacteria	G	Belongs to the GPI family	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD2_k127_6597949_8	1313172.YM304_30670	2.067e-51	193.0	COG0166@1|root,COG0363@1|root,COG0166@2|Bacteria,COG0363@2|Bacteria,2GJG0@201174|Actinobacteria,4CMVT@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD2_k127_6597949_7	1313172.YM304_30690	1.22e-74	263.0	COG2962@1|root,COG2962@2|Bacteria,2GKCP@201174|Actinobacteria	201174|Actinobacteria	S	RarD protein	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
HFD2_k127_6597949_11	114615.BRADO5379	1.902e-28	130.0	COG0683@1|root,COG2358@1|root,COG0683@2|Bacteria,COG2358@2|Bacteria,1R9K5@1224|Proteobacteria,2U123@28211|Alphaproteobacteria,3JXRI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3,Peripla_BP_6
HFD2_k127_6597949_10	1229780.BN381_630008	8.164e-30	127.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,3UWSG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
HFD2_k127_6597949_6	1313172.YM304_30780	1.305e-79	285.0	COG2321@1|root,COG2321@2|Bacteria,2HBKZ@201174|Actinobacteria	201174|Actinobacteria	S	neutral zinc metallopeptidase	lpqM	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD2_k127_6597949_2	1229780.BN381_80138	4.462e-135	452.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD2_k127_6597949_3	749927.AMED_1482	1.315e-115	384.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4E8IJ@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase, IS116 IS110 IS902	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD2_k127_6597949_5	1313172.YM304_30800	9.322e-85	295.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2778,PG_binding_1,YkuD
HFD2_k127_6597949_4	1313172.YM304_30810	8.572e-105	348.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD2_k127_6597949_1	1313172.YM304_18920	1.924e-167	533.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	GO:0000271,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HFD2_k127_6709495_9	1120950.KB892750_gene6897	6.845e-94	318.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_6709495_4	1206101.AZXC01000019_gene1547	9.129e-155	490.0	COG4312@1|root,COG4312@2|Bacteria,2GN8A@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HFD2_k127_6709495_15	1313172.YM304_03620	7.768e-30	128.0	2FKUI@1|root,34CEY@2|Bacteria,2HCF2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6709495_10	1313172.YM304_03610	2.527e-82	288.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4CNAY@84992|Acidimicrobiia	84992|Acidimicrobiia	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD2_k127_6709495_20	367299.JOEE01000001_gene1887	7.886e-07	62.0	COG4965@1|root,COG4965@2|Bacteria,2H1G9@201174|Actinobacteria,4FI36@85021|Intrasporangiaceae	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_6709495_16	1313172.YM304_03590	2.452e-29	130.0	COG2064@1|root,COG2064@2|Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein F	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_6709495_17	1313172.YM304_03570	3.612e-18	88.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_6709495_19	350054.Mflv_4424	3.609e-07	56.0	COG1366@1|root,COG1366@2|Bacteria,2IMFI@201174|Actinobacteria,23AI2@1762|Mycobacteriaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
HFD2_k127_6709495_14	419947.MRA_1886	1.465e-61	214.0	COG3467@1|root,COG3467@2|Bacteria,2IG17@201174|Actinobacteria,238QA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_6709495_22	1227349.C170_09925	0.0001884	53.0	COG4225@1|root,COG4225@2|Bacteria,1TS2C@1239|Firmicutes,4HCH5@91061|Bacilli,26U5C@186822|Paenibacillaceae	91061|Bacilli	S	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
HFD2_k127_6709495_1	469383.Cwoe_4008	3.564e-198	626.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4CPEP@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_6709495_7	208439.AJAP_05790	2.078e-116	385.0	COG3491@1|root,COG3491@2|Bacteria,2GT52@201174|Actinobacteria,4E49D@85010|Pseudonocardiales	201174|Actinobacteria	C	non-haem dioxygenase in morphine synthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HFD2_k127_6709495_5	1313172.YM304_03500	1.884e-128	420.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HFD2_k127_6709495_2	1313172.YM304_41880	7.671e-195	633.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CNHT@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_6709495_0	1313172.YM304_03480	0.0	1260.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4CMPI@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
HFD2_k127_6709495_11	1313172.YM304_11680	8.177e-75	261.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6709495_12	1313172.YM304_03470	1.611e-66	232.0	COG0125@1|root,COG0125@2|Bacteria,2HF93@201174|Actinobacteria,4CNDK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD2_k127_6709495_8	1313172.YM304_03460	5.285e-96	335.0	COG0470@1|root,COG0470@2|Bacteria	2|Bacteria	L	replication factor c	holB	-	2.7.7.7	ko:K02341,ko:K02343,ko:K09384	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HFD2_k127_6709495_6	1313172.YM304_19770	2.427e-125	436.0	COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,EAL,GGDEF,PAS,PAS_4,PAS_9
HFD2_k127_6709495_21	457429.ABJI02000385_gene4489	0.000186	48.0	2EEUI@1|root,30DVN@2|Bacteria,2GWIW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6709495_13	1242864.D187_000281	6.886e-63	234.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,42WQU@68525|delta/epsilon subdivisions,2WTEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HFD2_k127_6709495_18	1122239.AULS01000002_gene748	2.271e-15	89.0	COG1917@1|root,COG1917@2|Bacteria,2HZN2@201174|Actinobacteria,4FT9H@85023|Microbacteriaceae	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6709495_23	1688.BCUN_0235	0.0005687	47.0	2DT1P@1|root,33I9U@2|Bacteria	2|Bacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD2_k127_6709495_3	765420.OSCT_0135	6.317e-194	611.0	COG0205@1|root,COG0205@2|Bacteria,2G5XX@200795|Chloroflexi,376PW@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_6773921_1	1121877.JQKF01000002_gene1700	1.438e-262	820.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4CN7I@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD2_k127_6773921_6	1209984.BN978_03142	1.136e-128	437.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,234JI@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_6773921_10	1313172.YM304_26940	2.478e-55	201.0	COG1985@1|root,COG1985@2|Bacteria,2HGX9@201174|Actinobacteria,4CNXF@84992|Acidimicrobiia	84992|Acidimicrobiia	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_6773921_11	1313172.YM304_26950	8.313e-53	190.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CN4B@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD2_k127_6773921_16	1313172.YM304_26960	1.029e-06	57.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD2_k127_6773921_8	1313172.YM304_26970	2.442e-94	312.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4CN5D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD2_k127_6773921_14	1313172.YM304_26980	1.748e-27	123.0	2EQSP@1|root,33ICH@2|Bacteria,2GWX9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6773921_4	1313172.YM304_26990	9.544e-152	491.0	COG0436@1|root,COG0436@2|Bacteria,2H440@201174|Actinobacteria,4CMXW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD2_k127_6773921_3	1313172.YM304_27000	5.886e-195	617.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CMWR@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD2_k127_6773921_7	1313172.YM304_27010	1.136e-99	342.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4CNYU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD2_k127_6773921_9	1033736.CAHK01000026_gene1559	8.299e-69	251.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4F92W@85019|Brevibacteriaceae	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD2_k127_6773921_2	1313172.YM304_27040	9.065e-238	742.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_6773921_12	1120792.JAFV01000001_gene2446	6.477e-43	167.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2UC5P@28211|Alphaproteobacteria,36YPR@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_6773921_0	263358.VAB18032_12245	1.249e-308	962.0	COG0468@1|root,COG1372@1|root,COG0468@2|Bacteria,COG1372@2|Bacteria,2GJ4P@201174|Actinobacteria,4DAV3@85008|Micromonosporales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD2_k127_6773921_15	1313172.YM304_27070	2.649e-24	107.0	COG5349@1|root,COG5349@2|Bacteria,2HCSH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HFD2_k127_6773921_5	1386089.N865_04535	9.206e-132	434.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FFWW@85021|Intrasporangiaceae	201174|Actinobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_6830529_13	1280948.HY36_13040	8.864e-11	68.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,43XD4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
HFD2_k127_6830529_4	1313172.YM304_04680	9.535e-68	251.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	ylcC	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_6830529_0	1313172.YM304_27740	4.839e-170	537.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CMZT@84992|Acidimicrobiia	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
HFD2_k127_6830529_7	65093.PCC7418_1862	1.632e-32	140.0	COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_6830529_8	358396.C445_02076	3.086e-31	141.0	COG2303@1|root,arCOG02233@2157|Archaea,2XU6F@28890|Euryarchaeota,23TIY@183963|Halobacteria	183963|Halobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_6830529_12	1120934.KB894404_gene823	7.514e-15	87.0	COG4447@1|root,COG4447@2|Bacteria,2GJF7@201174|Actinobacteria,4E7JT@85010|Pseudonocardiales	201174|Actinobacteria	G	cellulose binding	xeg74	-	-	-	-	-	-	-	-	-	-	-	BNR,CBM_2,RicinB_lectin_2
HFD2_k127_6830529_1	661478.OP10G_0912	1.029e-151	496.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,Glyco_trans_1_4,NAD_binding_8
HFD2_k127_6830529_5	324602.Caur_1636	6.262e-39	158.0	COG1216@1|root,COG1216@2|Bacteria,2G8VQ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_6830529_11	43989.cce_2351	3.905e-27	121.0	2BVGP@1|root,32QVG@2|Bacteria,1GGUG@1117|Cyanobacteria,3KI5P@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6830529_14	1303518.CCALI_02343	8.05e-10	70.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_6830529_10	644968.DFW101_0126	4.101e-28	129.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,42M2P@68525|delta/epsilon subdivisions,2WM2M@28221|Deltaproteobacteria,2MD72@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_6830529_3	326427.Cagg_2374	3.928e-79	277.0	COG1216@1|root,COG1216@2|Bacteria,2GAH6@200795|Chloroflexi,377WE@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD2_k127_6830529_2	326427.Cagg_2081	1.687e-110	381.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_6830529_6	324602.Caur_1478	9.111e-39	151.0	COG0110@1|root,COG0110@2|Bacteria,2G6D2@200795|Chloroflexi,376J8@32061|Chloroflexia	32061|Chloroflexia	S	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep
HFD2_k127_6839827_7	1380394.JADL01000009_gene3357	1.874e-132	430.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2U071@28211|Alphaproteobacteria,2JZMF@204441|Rhodospirillales	204441|Rhodospirillales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_6839827_18	1382356.JQMP01000003_gene2449	6.82e-05	52.0	COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia	189775|Thermomicrobia	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HFD2_k127_6839827_19	43759.JNWK01000005_gene742	0.0009318	47.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HFD2_k127_6839827_1	42256.RradSPS_2597	8.166e-274	856.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CPA7@84995|Rubrobacteria	84995|Rubrobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
HFD2_k127_6839827_8	1120950.KB892709_gene4156	1.001e-90	301.0	COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria,4DQUF@85009|Propionibacteriales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD2_k127_6839827_9	225937.HP15_3143	5.816e-81	273.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,1S3ER@1236|Gammaproteobacteria,46CT2@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_6839827_10	1283287.KB822589_gene1227	3.361e-78	271.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DQAP@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_6839827_12	446470.Snas_0751	1.466e-47	173.0	COG3339@1|root,COG3339@2|Bacteria,2IMCR@201174|Actinobacteria,4EZZQ@85014|Glycomycetales	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HFD2_k127_6839827_11	591158.SSMG_03444	7.684e-71	253.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_6839827_2	1089545.KB913037_gene1111	7.227e-233	736.0	COG3511@1|root,COG3511@2|Bacteria,2IGVY@201174|Actinobacteria,4E9NV@85010|Pseudonocardiales	201174|Actinobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HFD2_k127_6839827_3	1033730.CAHG01000012_gene2001	7.683e-195	630.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_6839827_6	882082.SaccyDRAFT_4273	9.419e-136	442.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_6839827_15	29306.JOBE01000005_gene3768	4.698e-21	97.0	COG0346@1|root,COG0346@2|Bacteria,2GMTB@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6839827_14	1380347.JNII01000006_gene1589	3.941e-33	132.0	2DGHS@1|root,2ZW1B@2|Bacteria,2H7G7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6839827_4	1380390.JIAT01000009_gene493	4.487e-194	619.0	COG1231@1|root,COG1231@2|Bacteria,2I8ZQ@201174|Actinobacteria,4CRBP@84995|Rubrobacteria	84995|Rubrobacteria	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD2_k127_6839827_5	479434.Sthe_0782	8.382e-161	519.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.1.341,2.1.2.10	ko:K00605,ko:K15066	ko00260,ko00627,ko00630,ko00670,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00627,map00630,map00670,map01100,map01110,map01120,map01130,map01200	M00532	R01221,R02300,R04125,R09271,R10136	RC00022,RC00069,RC00113,RC00183,RC00392,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_6839827_16	1370121.AUWS01000020_gene6620	1.796e-18	95.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,236D8@1762|Mycobacteriaceae	201174|Actinobacteria	T	helix_turn_helix, cAMP Regulatory protein	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_6839827_0	106370.Francci3_2615	5e-324	1014.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_6839827_13	251229.Chro_1482	4.785e-37	150.0	COG4221@1|root,COG4221@2|Bacteria,1G0GW@1117|Cyanobacteria,3VJPI@52604|Pleurocapsales	1117|Cyanobacteria	S	COGs COG0300 Short-chain dehydrogenase of various substrate specificities	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_6839827_17	1108045.GORHZ_098_00160	1.481e-16	79.0	COG0596@1|root,COG0596@2|Bacteria,2I7GQ@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_6847288_4	935261.JAGL01000019_gene584	1.471e-32	132.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,43HVG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfatase	pehA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HFD2_k127_6847288_0	1408164.MOLA814_00047	3.008e-175	562.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1KPQ3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_6847288_5	290399.Arth_2422	1.184e-31	142.0	COG3832@1|root,COG3832@2|Bacteria,2IKRU@201174|Actinobacteria	201174|Actinobacteria	S	Activator of hsp90 atpase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_6847288_3	1440053.JOEI01000020_gene861	2.247e-65	228.0	COG0174@1|root,COG0174@2|Bacteria,2IFHQ@201174|Actinobacteria	201174|Actinobacteria	E	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HFD2_k127_6847288_1	543728.Vapar_4989	1.386e-151	492.0	COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2VMBC@28216|Betaproteobacteria,4AH4B@80864|Comamonadaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase groes	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_zinc_N
HFD2_k127_6847288_2	1121946.AUAX01000015_gene5947	3.167e-122	420.0	COG0726@1|root,COG1404@1|root,COG0726@2|Bacteria,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4DADU@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Inhibitor_I9,P_proprotein,Peptidase_S8
HFD2_k127_6863538_1	1283283.ATXA01000001_gene347	3.049e-56	212.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GM4U@201174|Actinobacteria,4EUPX@85013|Frankiales	201174|Actinobacteria	KT	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
HFD2_k127_6863538_0	298655.KI912266_gene2210	5.145e-123	428.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4ETTY@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_6863538_3	1298863.AUEP01000011_gene622	7.027e-50	186.0	COG2120@1|root,COG2120@2|Bacteria,2IJD0@201174|Actinobacteria	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_6863538_4	643562.Daes_0280	3.404e-27	121.0	COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,42QVQ@68525|delta/epsilon subdivisions,2WMW1@28221|Deltaproteobacteria,2MCDV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HFD2_k127_6863538_2	710696.Intca_0370	5.143e-50	191.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4FFUZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_7018591_13	1120950.KB892708_gene4349	1.138e-59	208.0	COG4221@1|root,COG4221@2|Bacteria,2GJWX@201174|Actinobacteria,4DQ9X@85009|Propionibacteriales	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_7018591_18	685727.REQ_02560	7.456e-26	111.0	COG1734@1|root,COG1734@2|Bacteria,2I168@201174|Actinobacteria,4G2WZ@85025|Nocardiaceae	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD2_k127_7018591_16	227882.SAV_305	9.038e-45	183.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HFD2_k127_7018591_7	356851.JOAN01000003_gene1621	6.656e-145	469.0	COG1940@1|root,COG1940@2|Bacteria,2IB2E@201174|Actinobacteria,4D8WY@85008|Micromonosporales	201174|Actinobacteria	GK	ROK family	glcK	-	-	-	-	-	-	-	-	-	-	-	ROK
HFD2_k127_7018591_3	1121272.KB903249_gene2034	1.806e-226	718.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DB82@85008|Micromonosporales	201174|Actinobacteria	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
HFD2_k127_7018591_1	1121272.KB903249_gene2033	9.151e-256	800.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DBIN@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter ATPase permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
HFD2_k127_7018591_20	1095767.CAHD01000235_gene2859	4.963e-20	105.0	COG5549@1|root,COG5549@2|Bacteria,2IJMT@201174|Actinobacteria	201174|Actinobacteria	O	PFAM peptidase M10A and M12B, matrixin and adamalysin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HFD2_k127_7018591_12	1449355.JQNR01000003_gene547	6.724e-63	239.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K01173	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	FAD_oxidored,FTP,PPC,Peptidase_M4,Peptidase_M4_C,Peptidase_S8,SLH,VCBS
HFD2_k127_7018591_0	744980.TRICHSKD4_3309	0.0	1037.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_7018591_5	1380394.JADL01000010_gene4325	3.69e-201	639.0	COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria,2JVS6@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
HFD2_k127_7018591_10	768066.HELO_1452	1.826e-83	298.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1S2WF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.3.48	ko:K19714	-	-	R11394	RC03427	ko00000,ko01000,ko01005	-	-	-	Fe-ADH
HFD2_k127_7018591_6	1504672.669786111	1.076e-156	505.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2VK18@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	5.5.1.1	ko:K01856	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_7018591_14	405948.SACE_5618	2.486e-55	208.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,4E35Z@85010|Pseudonocardiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HFD2_k127_7018591_4	1380394.JADL01000010_gene4324	7.055e-216	709.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,2JRHD@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
HFD2_k127_7018591_2	1313172.YM304_35720	7.035e-231	732.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2HE4H@201174|Actinobacteria	201174|Actinobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HFD2_k127_7018591_8	1313172.YM304_35710	1.76e-133	447.0	COG1410@1|root,COG1410@2|Bacteria,2IC7C@201174|Actinobacteria	201174|Actinobacteria	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD2_k127_7018591_22	388399.SSE37_05225	3.748e-10	71.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
HFD2_k127_7018591_15	1089551.KE386572_gene3994	8.73e-51	187.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,4BQ8X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
HFD2_k127_7018591_9	1313172.YM304_35690	3.048e-113	387.0	COG5012@1|root,COG5012@2|Bacteria,2IEGQ@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HFD2_k127_7018591_11	1281779.H009_21556	1.428e-67	241.0	COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2TUQG@28211|Alphaproteobacteria,4BBT9@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HFD2_k127_7018591_19	983920.Y88_1139	4.963e-25	118.0	COG3221@1|root,COG3221@2|Bacteria,1RDG5@1224|Proteobacteria,2U8X7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
HFD2_k127_7018591_21	1169161.KB897737_gene2328	1.375e-19	96.0	COG1309@1|root,COG1309@2|Bacteria,2IIPZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_7018591_17	1313172.YM304_07630	1.753e-36	139.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4CP4B@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HFD2_k127_70343_15	28444.JODQ01000001_gene2347	3.292e-05	49.0	COG3832@1|root,COG3945@1|root,COG3832@2|Bacteria,COG3945@2|Bacteria,2IKF0@201174|Actinobacteria,4EPWI@85012|Streptosporangiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_70343_2	675635.Psed_5589	1.779e-172	557.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4DXD2@85010|Pseudonocardiales	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_70343_12	290340.AAur_0786	5.455e-21	106.0	29YYI@1|root,30KVC@2|Bacteria,2IGN9@201174|Actinobacteria	201174|Actinobacteria	S	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD
HFD2_k127_70343_8	1313172.YM304_05910	1.217e-69	245.0	2CNM1@1|root,32SHB@2|Bacteria,2GKWT@201174|Actinobacteria,4CNV1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD
HFD2_k127_70343_9	1313172.YM304_09080	4.664e-67	248.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_70343_6	926560.KE387023_gene2306	7.305e-129	423.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	cefD	-	5.1.1.17	ko:K04127,ko:K11325,ko:K21174	ko00311,ko01059,ko01100,ko01130,map00311,map01059,map01100,map01130	M00673,M00825	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HFD2_k127_70343_3	1313172.YM304_29530	1.748e-167	544.0	COG4715@1|root,COG4715@2|Bacteria,2GKC8@201174|Actinobacteria	201174|Actinobacteria	K	PFAM zinc finger SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HFD2_k127_70343_13	67267.JNXT01000039_gene3499	2.463e-09	69.0	COG5094@1|root,COG5094@2|Bacteria,2I306@201174|Actinobacteria	201174|Actinobacteria	K	RNA polymerase II transcriptional preinitiation complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_70343_1	235985.BBPN01000042_gene8464	7.567e-175	559.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria,2NGI9@228398|Streptacidiphilus	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HFD2_k127_70343_0	1313172.YM304_29500	4.991e-257	835.0	COG1916@1|root,COG1916@2|Bacteria,2H79D@201174|Actinobacteria	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_70343_5	1313172.YM304_29490	1.682e-144	470.0	COG2425@1|root,COG2425@2|Bacteria,2GK1P@201174|Actinobacteria	201174|Actinobacteria	S	VWA containing CoxE family protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HFD2_k127_70343_11	298655.KI912266_gene5433	7.173e-22	108.0	COG0454@1|root,COG0456@2|Bacteria,2GVT5@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HFD2_k127_70343_4	1229780.BN381_250066	2.52e-158	509.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_70343_10	1306990.BARG01000033_gene3962	1.277e-53	201.0	COG0511@1|root,COG0511@2|Bacteria,2GMCA@201174|Actinobacteria	201174|Actinobacteria	I	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HFD2_k127_70343_7	1179773.BN6_37750	5.961e-113	374.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4DZUP@85010|Pseudonocardiales	201174|Actinobacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD2_k127_70343_14	1313172.YM304_29470	2.285e-07	57.0	2C1D9@1|root,2ZD16@2|Bacteria,2HBJG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7059966_5	1313172.YM304_12170	1.255e-30	123.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HFD2_k127_7059966_1	639283.Snov_4118	4.387e-167	540.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,3F0GC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_7059966_0	1313172.YM304_08150	0.0	1157.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4CMTM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_7059966_2	1146883.BLASA_4628	4.114e-121	406.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4ETW3@85013|Frankiales	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_7059966_3	1907.SGLAU_29295	8.478e-51	185.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K15945	ko01057,ko01130,map01057,map01130	-	R09330	RC00046	ko00000,ko00001	-	-	-	SnoaL,SnoaL_2
HFD2_k127_7059966_4	1304865.JAGF01000001_gene2482	1.798e-39	156.0	COG0730@1|root,COG0730@2|Bacteria,2GK5W@201174|Actinobacteria	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_7059966_6	1313172.YM304_08160	1.627e-14	82.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_7089815_8	1313172.YM304_11580	1.029e-44	167.0	COG2087@1|root,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4CND7@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobP	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
HFD2_k127_7089815_5	1313172.YM304_11570	2e-121	403.0	COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4CN1T@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HFD2_k127_7089815_7	1313172.YM304_11560	4.582e-70	253.0	COG0368@1|root,COG0368@2|Bacteria,2HGZT@201174|Actinobacteria,4CP01@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HFD2_k127_7089815_2	1313172.YM304_11540	4.315e-184	584.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CMWF@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD2_k127_7089815_3	1313172.YM304_11530	6.81e-166	530.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4CMWA@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD2_k127_7089815_6	1313172.YM304_11520	2.114e-76	280.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CN4A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HFD2_k127_7089815_0	1313172.YM304_11500	9.18e-220	687.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4CNG3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_7089815_1	1211815.CBYP010000068_gene194	2.573e-188	619.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7089815_4	1313172.YM304_11450	2.912e-160	512.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4CMV2@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HFD2_k127_7089815_9	1313172.YM304_11440	4.475e-13	69.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CN3W@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HFD2_k127_7097712_7	1283299.AUKG01000001_gene1884	1.811e-11	75.0	2AX1H@1|root,31NZQ@2|Bacteria,2HRFY@201174|Actinobacteria,4CTEV@84995|Rubrobacteria	84995|Rubrobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
HFD2_k127_7097712_5	273677.BW34_02226	3.209e-41	172.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4FKUV@85023|Microbacteriaceae	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HFD2_k127_7097712_1	1313172.YM304_10830	1.623e-275	885.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HFD2_k127_7097712_3	1313172.YM304_10820	2.042e-135	441.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_7097712_0	1313172.YM304_10810	6.084e-289	908.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD2_k127_7097712_4	1313172.YM304_10790	5.821e-100	336.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4CMYM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_7097712_2	1313172.YM304_10780	2.277e-149	477.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4CMYQ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD2_k127_7097712_6	1313172.YM304_10770	2.069e-28	117.0	COG0694@1|root,COG0694@2|Bacteria,2HGE4@201174|Actinobacteria,4CNCF@84992|Acidimicrobiia	84992|Acidimicrobiia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
HFD2_k127_7133041_2	1313172.YM304_05040	6.734e-118	385.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CN4A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HFD2_k127_7133041_8	869210.Marky_0019	8.892e-43	173.0	COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1WJBI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4
HFD2_k127_7133041_7	1313172.YM304_05050	4.953e-46	169.0	COG0454@1|root,COG0456@2|Bacteria,2IMVD@201174|Actinobacteria,4CNB7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_7133041_6	1313172.YM304_05060	3.66e-57	208.0	COG1413@1|root,COG1413@2|Bacteria,2HA0J@201174|Actinobacteria,4CNCY@84992|Acidimicrobiia	84992|Acidimicrobiia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HFD2_k127_7133041_5	1313172.YM304_05080	7.55e-66	246.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
HFD2_k127_7133041_1	1313172.YM304_05090	1.387e-149	497.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
HFD2_k127_7133041_0	1313172.YM304_05100	3.251e-277	893.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4CMW1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD2_k127_7133041_9	1313172.YM304_05110	2.262e-17	95.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K19765	ko04212,map04212	-	-	-	ko00000,ko00001	-	-	-	-
HFD2_k127_7133041_12	406818.XBJ1_3704	9.259e-08	56.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7133041_4	1229780.BN381_210015	4.34e-69	238.0	COG3311@1|root,COG3311@2|Bacteria,2IQFY@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD2_k127_7133041_11	1229780.BN381_360011	1.684e-08	62.0	28MHU@1|root,2ZAUM@2|Bacteria,2H6R3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7133041_3	1121272.KB903249_gene2267	2.701e-73	250.0	28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7152079_12	1313172.YM304_09850	7.639e-43	162.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4CMRV@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Histidine kinase	-	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2
HFD2_k127_7152079_18	1313172.YM304_09820	1.665e-21	98.0	2E3M2@1|root,31DE4@2|Bacteria,2HH0X@201174|Actinobacteria,4CP16@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
HFD2_k127_7152079_3	1209984.BN978_01231	4.916e-115	381.0	COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria,2362H@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0044419,GO:0044464,GO:0050789,GO:0050794,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HFD2_k127_7152079_5	1440774.Y900_013130	4.292e-90	301.0	COG0693@1|root,COG0693@2|Bacteria,2H6FV@201174|Actinobacteria,232C9@1762|Mycobacteriaceae	201174|Actinobacteria	S	DJ-1 PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HFD2_k127_7152079_10	1121877.JQKF01000016_gene162	5.17e-46	175.0	COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_7152079_0	1313172.YM304_09730	1.122e-182	578.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2GJUZ@201174|Actinobacteria,4CMV4@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
HFD2_k127_7152079_6	368407.Memar_0194	1.255e-70	250.0	COG0500@1|root,arCOG01791@2157|Archaea	2157|Archaea	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_7152079_1	1313172.YM304_17300	1.938e-173	554.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4CNYP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
HFD2_k127_7152079_8	298655.KI912267_gene7140	1.517e-55	221.0	COG0577@1|root,COG0577@2|Bacteria,2GWZR@201174|Actinobacteria	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HFD2_k127_7152079_7	358681.BBR47_55670	8.961e-67	233.0	COG2041@1|root,COG2041@2|Bacteria,1UMMR@1239|Firmicutes,4HF9N@91061|Bacilli,275MG@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD2_k127_7152079_17	1313172.YM304_09680	1.127e-31	139.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	3.6.1.55	ko:K03574,ko:K08296	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
HFD2_k127_7152079_19	1380393.JHVP01000013_gene3428	2.221e-20	94.0	COG0515@1|root,COG0515@2|Bacteria	1380393.JHVP01000013_gene3428|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7152079_13	1313172.YM304_09660	6.027e-41	158.0	COG3088@1|root,COG3088@2|Bacteria,2GTYU@201174|Actinobacteria	201174|Actinobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HFD2_k127_7152079_9	1313172.YM304_09650	8.53e-48	179.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	-
HFD2_k127_7152079_2	671143.DAMO_1588	3.96e-154	511.0	COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198,ko:K04016	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD2_k127_7152079_11	1313172.YM304_09630	2.826e-44	174.0	COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria,4CNCV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HFD2_k127_7152079_4	1313172.YM304_09620	1.633e-90	309.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CN1E@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HFD2_k127_7152079_16	1313172.YM304_09610	2.769e-32	127.0	COG2386@1|root,COG2386@2|Bacteria,2HG7F@201174|Actinobacteria,4CN4H@84992|Acidimicrobiia	84992|Acidimicrobiia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HFD2_k127_7157271_31	1210045.ALNP01000001_gene3213	3.639e-34	139.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_7157271_34	526225.Gobs_0814	5.11e-29	133.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4ERU5@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7157271_1	1313172.YM304_21060	1.006e-317	980.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CMUT@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD2_k127_7157271_37	1416759.AYMR01000004_gene3492	5.552e-17	83.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4FPN2@85023|Microbacteriaceae	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD2_k127_7157271_17	1313172.YM304_21030	1.134e-111	369.0	COG1466@1|root,COG1466@2|Bacteria,2HGGN@201174|Actinobacteria,4CNDU@84992|Acidimicrobiia	84992|Acidimicrobiia	L	dna polymerase III delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	-
HFD2_k127_7157271_13	1313172.YM304_21020	1.942e-118	396.0	COG0658@1|root,COG0658@2|Bacteria,2GJGR@201174|Actinobacteria	201174|Actinobacteria	L	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HFD2_k127_7157271_27	1313172.YM304_21000	1.689e-48	182.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria	201174|Actinobacteria	L	Competence protein ComEA	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HFD2_k127_7157271_40	1307437.J139_20332	0.0006452	48.0	2B6WS@1|root,31ZWK@2|Bacteria,1RCZJ@1224|Proteobacteria,1S3NQ@1236|Gammaproteobacteria,2Q2GC@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7157271_22	1313172.YM304_20990	1.284e-91	309.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_20,Thioredoxin
HFD2_k127_7157271_18	1123320.KB889669_gene3247	2.166e-103	350.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_7157271_23	1313172.YM304_20980	6.907e-85	296.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HFD2_k127_7157271_8	1313172.YM304_20970	4.504e-162	534.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7157271_2	1313172.YM304_26510	1.622e-261	861.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	pks16	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019752,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0051704,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	6.2.1.20	ko:K00666,ko:K01909	ko00071,map00071	-	R01406	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AMP-binding_C_2
HFD2_k127_7157271_0	1313172.YM304_26580	0.0	1410.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CMQM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HFD2_k127_7157271_9	235985.BBPN01000027_gene1594	2.332e-154	510.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,2NG6I@228398|Streptacidiphilus	201174|Actinobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_7157271_16	1435356.Y013_16795	1.342e-114	386.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,4FXE2@85025|Nocardiaceae	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_7157271_10	1229780.BN381_10328	1.957e-134	459.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,3UX6E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_7157271_3	1313172.YM304_38870	3.321e-194	661.0	COG1033@1|root,COG1033@2|Bacteria,2I731@201174|Actinobacteria	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_7157271_7	1048339.KB913029_gene4489	4.722e-164	531.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4ETYU@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7157271_32	591158.SSMG_04763	7.632e-31	141.0	COG0577@1|root,COG0577@2|Bacteria,2IE56@201174|Actinobacteria	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HFD2_k127_7157271_28	591158.SSMG_04762	1.629e-45	173.0	COG1136@1|root,COG1136@2|Bacteria,2IH0C@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
HFD2_k127_7157271_29	1380393.JHVP01000012_gene2805	2.191e-41	163.0	COG1136@1|root,COG1136@2|Bacteria,2IGR1@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7157271_20	1035308.AQYY01000002_gene158	1.437e-96	329.0	COG0438@1|root,COG0438@2|Bacteria,1TS5D@1239|Firmicutes,24DQ1@186801|Clostridia,265B2@186807|Peptococcaceae	186801|Clostridia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,MannoseP_isomer
HFD2_k127_7157271_12	469371.Tbis_2294	1.409e-126	421.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4DYIK@85010|Pseudonocardiales	201174|Actinobacteria	G	synthase	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
HFD2_k127_7157271_41	1144305.PMI02_04457	0.0007525	51.0	COG0561@1|root,COG0561@2|Bacteria,1MXIH@1224|Proteobacteria,2TTNZ@28211|Alphaproteobacteria,2K1PZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HFD2_k127_7157271_4	351607.Acel_0139	7e-188	611.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4EUUE@85013|Frankiales	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HFD2_k127_7157271_26	1123320.KB889681_gene2592	9.747e-49	188.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_7157271_6	1123320.KB889681_gene2589	9.388e-173	548.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_7157271_25	930166.CD58_17270	1.647e-49	186.0	COG3665@1|root,COG3665@2|Bacteria,1R7PG@1224|Proteobacteria,1RYU6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
HFD2_k127_7157271_33	1463887.KL589960_gene3468	1.154e-30	139.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	Beta_helix,CBM60,CBM9_1,Glyco_hydro_8,PKD,Polysacc_deac_1,SprB
HFD2_k127_7157271_14	1206726.BAFV01000041_gene3087	1.217e-117	398.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4FWN1@85025|Nocardiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_7157271_24	208444.JNYY01000043_gene3282	4.591e-75	258.0	COG2318@1|root,COG2318@2|Bacteria,2GMS2@201174|Actinobacteria,4E62W@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HFD2_k127_7157271_11	1318628.MARLIPOL_02925	4.421e-133	434.0	COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,1T3EJ@1236|Gammaproteobacteria,466GD@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HFD2_k127_7157271_30	159450.NH14_30335	3.338e-37	158.0	COG0664@1|root,COG0664@2|Bacteria,1N3F0@1224|Proteobacteria,2VVAQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD2_k127_7157271_21	35754.JNYJ01000042_gene1375	8.806e-92	310.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4DCVX@85008|Micromonosporales	201174|Actinobacteria	CH	Oxidoreductase NAD-binding domain	asrB	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HFD2_k127_7157271_15	595536.ADVE02000001_gene768	8.195e-117	383.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,36ZAX@31993|Methylocystaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
HFD2_k127_7157271_5	543632.JOJL01000027_gene2900	1.138e-178	571.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria,4DABR@85008|Micromonosporales	201174|Actinobacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HFD2_k127_7157271_35	1288079.AUKN01000007_gene1846	1.077e-22	109.0	COG0680@1|root,COG0680@2|Bacteria,2IJ3P@201174|Actinobacteria	201174|Actinobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HFD2_k127_7157271_19	196162.Noca_2727	1.276e-98	329.0	COG3266@1|root,COG3266@2|Bacteria,2HMYI@201174|Actinobacteria,4DU07@85009|Propionibacteriales	201174|Actinobacteria	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HFD2_k127_7157271_39	1385518.N798_16410	1.956e-07	54.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FE8Z@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_12
HFD2_k127_7160445_0	552811.Dehly_0076	2.692e-130	426.0	COG3039@1|root,COG3039@2|Bacteria,2G9US@200795|Chloroflexi,34D8F@301297|Dehalococcoidia	2|Bacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HFD2_k127_7160445_6	1068980.ARVW01000001_gene7052	9.889e-05	48.0	COG0262@1|root,COG0262@2|Bacteria,2GPXM@201174|Actinobacteria,4E9WD@85010|Pseudonocardiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_7160445_2	396014.BF93_02715	5.269e-87	291.0	COG0262@1|root,COG0262@2|Bacteria,2GJJD@201174|Actinobacteria,4FD4F@85020|Dermabacteraceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_7160445_5	525368.HMPREF0591_4368	2.892e-14	75.0	COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,237RJ@1762|Mycobacteriaceae	201174|Actinobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HFD2_k127_7160445_1	1313172.YM304_12030	4.212e-89	304.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_7160445_4	1380393.JHVP01000019_gene78	3.247e-16	80.0	2EGSG@1|root,33AIJ@2|Bacteria,2GWW3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
HFD2_k127_7160445_3	1121106.JQKB01000003_gene2621	4.317e-68	237.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2JVIA@204441|Rhodospirillales	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7163964_21	1278078.G419_21297	9.881e-48	183.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4G9I9@85025|Nocardiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_7163964_24	292564.Cyagr_2443	5.548e-44	167.0	COG0406@1|root,COG0406@2|Bacteria,1GDV3@1117|Cyanobacteria,22TP4@167375|Cyanobium	1117|Cyanobacteria	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD2_k127_7163964_11	1313172.YM304_21110	7.45e-119	392.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4CN2R@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
HFD2_k127_7163964_13	1229780.BN381_80272	1.877e-113	379.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,3UWDM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_7163964_25	1313172.YM304_21130	1.398e-37	152.0	COG1385@1|root,COG1385@2|Bacteria,2HGFD@201174|Actinobacteria,4CND1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD2_k127_7163964_17	1313172.YM304_21140	1.043e-66	232.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria,4CN5U@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HFD2_k127_7163964_7	1313172.YM304_21150	7.141e-146	473.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4CNTM@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_7163964_26	1132441.KI519455_gene2650	3.672e-14	83.0	2C1E1@1|root,33ZS5@2|Bacteria,2H64C@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7163964_3	228410.NE0091	8.68e-194	627.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,3722H@32003|Nitrosomonadales	28216|Betaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,Usp
HFD2_k127_7163964_12	1283299.AUKG01000001_gene2437	4.323e-118	419.0	COG3899@1|root,COG3899@2|Bacteria,2HFRA@201174|Actinobacteria,4CR76@84995|Rubrobacteria	84995|Rubrobacteria	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
HFD2_k127_7163964_19	1298863.AUEP01000007_gene410	4.495e-51	187.0	2B3JS@1|root,31W90@2|Bacteria,2GP1G@201174|Actinobacteria,4DVEW@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7163964_5	706587.Desti_4338	6.853e-188	593.0	COG2502@1|root,COG2502@2|Bacteria,1MVWF@1224|Proteobacteria	1224|Proteobacteria	E	aspartate--ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA,tRNA-synt_2
HFD2_k127_7163964_16	1123368.AUIS01000001_gene1949	7.397e-68	234.0	2C4GJ@1|root,2ZD2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7163964_0	1123368.AUIS01000001_gene1948	8.848e-255	806.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,1RYY4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HFD2_k127_7163964_27	1108045.GORHZ_060_00330	1.192e-09	67.0	COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria,4GC4U@85026|Gordoniaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HFD2_k127_7163964_10	479435.Kfla_0432	3.779e-136	440.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4DTWY@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_7163964_22	1122611.KB903963_gene4645	1.202e-46	178.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4EQYN@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_7163964_6	1313172.YM304_41990	1.053e-169	543.0	COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
HFD2_k127_7163964_23	1078020.KEK_19134	3.989e-45	175.0	COG0741@1|root,COG0741@2|Bacteria,2IBCH@201174|Actinobacteria,2359I@1762|Mycobacteriaceae	201174|Actinobacteria	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460,NLPC_P60,SLT,SLT_2
HFD2_k127_7163964_4	1313172.YM304_21200	3.486e-193	609.0	COG1960@1|root,COG1960@2|Bacteria,2GJ7S@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_7163964_1	379066.GAU_2329	7.672e-232	721.0	COG0538@1|root,COG0538@2|Bacteria,1ZUHH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_7163964_14	1313172.YM304_23490	5.873e-105	362.0	COG3848@1|root,COG3848@2|Bacteria,2IE61@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HFD2_k127_7163964_9	1313172.YM304_38560	5.237e-137	442.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4CN5N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_7163964_8	43759.JNWK01000001_gene5633	2.579e-140	467.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD2_k127_7163964_18	1313172.YM304_38600	9.884e-63	240.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD2_k127_7163964_15	1313172.YM304_38610	1.689e-84	293.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4CNQN@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_7163964_2	1313172.YM304_21230	1.466e-221	692.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CMS9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD2_k127_7163964_20	1313172.YM304_21250	8.49e-50	178.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMQK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HFD2_k127_7182649_4	1313172.YM304_19800	1.398e-63	220.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CNA7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD2_k127_7182649_3	1313172.YM304_19790	2.623e-76	259.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria	201174|Actinobacteria	J	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD2_k127_7182649_1	1313172.YM304_19780	2.603e-123	407.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4CN3N@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
HFD2_k127_7182649_2	1313172.YM304_06500	2.079e-83	293.0	COG2141@1|root,COG2141@2|Bacteria,2H89R@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7182649_5	298654.FraEuI1c_2872	4.009e-15	80.0	COG1141@1|root,COG1141@2|Bacteria,2HWGX@201174|Actinobacteria,4EWTB@85013|Frankiales	201174|Actinobacteria	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
HFD2_k127_7182649_0	1120936.KB907225_gene2778	1.459e-125	413.0	COG2124@1|root,COG2124@2|Bacteria,2HMMY@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HFD2_k127_7182649_6	935548.KI912159_gene6126	0.0004972	46.0	COG4454@1|root,COG4454@2|Bacteria,1N1PE@1224|Proteobacteria,2UCWF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SoxE
HFD2_k127_719085_7	1187851.A33M_3731	3.592e-07	53.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
HFD2_k127_719085_4	1313172.YM304_27560	2.6e-95	319.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4CN0W@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_719085_0	1313172.YM304_27540	1.31e-179	579.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria	201174|Actinobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD2_k127_719085_3	1313172.YM304_27530	7.389e-102	343.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD2_k127_719085_1	1313172.YM304_27520	1.321e-110	366.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CN5T@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_719085_2	1313172.YM304_27510	3.425e-107	354.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4CMYZ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_719085_6	1313172.YM304_27500	2.514e-30	127.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	3.4.24.75	ko:K08259,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD2_k127_719085_5	1313172.YM304_27490	2.024e-67	242.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4CMWX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S2	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD2_k127_7200512_11	1313172.YM304_35550	4.125e-91	304.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_7200512_1	1313172.YM304_35560	1.782e-240	752.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	201174|Actinobacteria	C	Protein synonym NADH dehydrogenase I subunit M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_7200512_0	1313172.YM304_35570	6.117e-246	779.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia	201174|Actinobacteria	CP	protein synonym multiple resistance and pH homeostasis protein A	-	-	1.6.5.3	ko:K00341,ko:K05565	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	DUF4040,Proton_antipo_M,Proton_antipo_N
HFD2_k127_7200512_19	1313172.YM304_35580	1.452e-35	151.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD2_k127_7200512_13	1313172.YM304_35590	6.918e-51	187.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD2_k127_7200512_10	1313172.YM304_35600	1.3e-92	306.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HFD2_k127_7200512_5	1313172.YM304_35610	2.618e-173	551.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD2_k127_7200512_3	1313172.YM304_35620	1.305e-231	719.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HFD2_k127_7200512_20	35754.JNYJ01000004_gene6014	4.263e-32	134.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4DBTZ@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD2_k127_7200512_9	1313172.YM304_35640	2.55e-94	318.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD2_k127_7200512_12	1313172.YM304_35650	2.424e-55	196.0	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD2_k127_7200512_22	1380347.JNII01000005_gene2882	1.767e-09	70.0	COG1520@1|root,COG4932@1|root,COG1520@2|Bacteria,COG4932@2|Bacteria,2GPF1@201174|Actinobacteria	201174|Actinobacteria	M	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR
HFD2_k127_7200512_14	1380390.JIAT01000010_gene3534	4.505e-50	190.0	COG0510@1|root,COG0510@2|Bacteria,2IAJ7@201174|Actinobacteria,4CR72@84995|Rubrobacteria	84995|Rubrobacteria	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase
HFD2_k127_7200512_18	68170.KL590511_gene2984	3.339e-40	157.0	COG3576@1|root,COG3576@2|Bacteria,2I46F@201174|Actinobacteria,4EDRQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_7200512_7	28042.GU90_11070	1.336e-146	484.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DXZW@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD2_k127_7200512_16	1283287.KB822581_gene1473	1.477e-46	176.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,4DVHW@85009|Propionibacteriales	201174|Actinobacteria	F	Peptidase C26	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HFD2_k127_7200512_8	1283299.AUKG01000002_gene4294	4.985e-138	451.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4CS00@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_7200512_15	680198.SCAB_9761	4.007e-48	181.0	COG2071@1|root,COG2071@2|Bacteria,2HRHB@201174|Actinobacteria	201174|Actinobacteria	S	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HFD2_k127_7200512_17	66377.JOBH01000001_gene1299	2.039e-46	179.0	COG2071@1|root,COG2071@2|Bacteria,2HRHB@201174|Actinobacteria	201174|Actinobacteria	S	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HFD2_k127_7200512_21	525368.HMPREF0591_2025	3.448e-11	74.0	COG5340@1|root,COG5340@2|Bacteria,2I56S@201174|Actinobacteria,23FER@1762|Mycobacteriaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4,DUF559
HFD2_k127_7200512_4	1313172.YM304_04190	1.547e-182	586.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_7200512_2	1313172.YM304_04180	1.487e-236	743.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein synonym NADH dehydrogenase I subunit M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_7200512_6	1313172.YM304_04170	6.735e-163	523.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia	84992|Acidimicrobiia	CP	protein synonym multiple resistance and pH homeostasis protein A	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HFD2_k127_7252655_11	711393.AYRX01000077_gene579	1.469e-18	90.0	COG2905@1|root,COG2905@2|Bacteria,2IJJ6@201174|Actinobacteria	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_7252655_10	1463900.JOIX01000025_gene5769	9.139e-21	100.0	COG1254@1|root,COG1254@2|Bacteria	2|Bacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HFD2_k127_7252655_9	1313172.YM304_05660	4.268e-41	166.0	COG2050@1|root,COG2050@2|Bacteria,2IJB2@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_7252655_3	1454004.AW11_01835	4.666e-67	255.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2VX35@28216|Betaproteobacteria	28216|Betaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7252655_5	522306.CAP2UW1_0032	3.558e-59	232.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria,2VX2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7252655_2	652103.Rpdx1_3644	5.414e-97	333.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2U3P9@28211|Alphaproteobacteria,3JRA5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_7252655_7	443218.AS9A_2146	1.063e-54	198.0	2CAJE@1|root,33XCP@2|Bacteria,2IMDF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7252655_0	1120953.AUBH01000004_gene3093	1.683e-126	417.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
HFD2_k127_7252655_4	1229780.BN381_130166	4.844e-67	235.0	2DCZU@1|root,2ZFYS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7252655_6	290397.Adeh_0453	5.576e-56	207.0	COG0500@1|root,COG0500@2|Bacteria,1R947@1224|Proteobacteria,432GY@68525|delta/epsilon subdivisions,2WYII@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7252655_1	1463887.KL589971_gene4535	1.604e-113	374.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7252655_8	1121877.JQKF01000018_gene2559	2.27e-52	192.0	COG0842@1|root,COG0842@2|Bacteria,2GP9E@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_7284693_6	1463920.JOGB01000047_gene3015	3.225e-11	67.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD2_k127_7284693_3	1313172.YM304_16680	2.241e-44	169.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HFD2_k127_7284693_0	525909.Afer_0575	6.937e-184	589.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4CNF6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HFD2_k127_7284693_1	671143.DAMO_1031	6.807e-137	457.0	COG0155@1|root,COG0155@2|Bacteria,2NPHB@2323|unclassified Bacteria	2|Bacteria	P	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1	ko:K00362,ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00530,M00531	R00787,R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	HEPN,NIR_SIR,NIR_SIR_ferr
HFD2_k127_7284693_4	1397528.Q671_15750	2.192e-41	162.0	COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,1S7ZE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Domain of unknown function (DUF4202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4202
HFD2_k127_7284693_5	29581.BW37_01655	1.332e-17	88.0	COG0454@1|root,COG0456@2|Bacteria,1N29T@1224|Proteobacteria,2WAXZ@28216|Betaproteobacteria,477Z2@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_7284693_2	1313172.YM304_29070	7.514e-93	309.0	COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria,4CNEX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
HFD2_k127_7305940_2	710685.MycrhN_3880	1.801e-219	691.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,234NV@1762|Mycobacteriaceae	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_7305940_6	1313172.YM304_13810	4.474e-122	399.0	COG2141@1|root,COG2141@2|Bacteria,2GJ3B@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_3544 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7305940_13	477641.MODMU_5260	2.601e-49	181.0	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4ET24@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_7305940_1	1313172.YM304_16690	1.682e-278	863.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMUP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD2_k127_7305940_12	1313172.YM304_30600	2.933e-53	192.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HFD2_k127_7305940_3	1268303.RHODMAR_1647	4.309e-166	527.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FVXV@85025|Nocardiaceae	201174|Actinobacteria	L	DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
HFD2_k127_7305940_10	1032480.MLP_12660	2.585e-58	205.0	COG0346@1|root,COG0346@2|Bacteria,2II51@201174|Actinobacteria,4DRYS@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7305940_8	706587.Desti_0222	7.704e-70	242.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MQ3X@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_7305940_17	1380390.JIAT01000014_gene6141	8.938e-09	64.0	COG3832@1|root,COG3832@2|Bacteria,2HNBH@201174|Actinobacteria,4CQP8@84995|Rubrobacteria	84995|Rubrobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_7305940_15	1172181.KB911700_gene7736	4.063e-25	114.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_7305940_0	1035308.AQYY01000001_gene2285	3.047e-281	884.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,2607A@186807|Peptococcaceae	186801|Clostridia	J	PFAM tRNA synthetases class I (E and Q), catalytic domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HFD2_k127_7305940_16	1123320.KB889674_gene4179	1.575e-15	88.0	2EMGF@1|root,33F55@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7305940_14	1122138.AQUZ01000049_gene2410	2.358e-47	178.0	COG1309@1|root,COG1309@2|Bacteria,2IJP2@201174|Actinobacteria,4DSE4@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HFD2_k127_7305940_11	2055.JNXA01000009_gene1445	5.65e-57	207.0	2DKYM@1|root,30WWW@2|Bacteria,2IGAV@201174|Actinobacteria,4GBDR@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1353)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
HFD2_k127_7305940_4	1380347.JNII01000005_gene3091	2.575e-162	529.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4ET3G@85013|Frankiales	201174|Actinobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HFD2_k127_7305940_7	105559.Nwat_1530	5.941e-82	288.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,1RP8E@1236|Gammaproteobacteria,1X06N@135613|Chromatiales	135613|Chromatiales	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD2_k127_7305940_9	1380390.JIAT01000011_gene2883	4.386e-64	253.0	COG0028@1|root,COG0515@1|root,COG1409@1|root,COG1749@1|root,COG2374@1|root,COG3291@1|root,COG3509@1|root,COG4733@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1409@2|Bacteria,COG1749@2|Bacteria,COG2374@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG4733@2|Bacteria,2I2X3@201174|Actinobacteria,4CSIX@84995|Rubrobacteria	84995|Rubrobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,fn3
HFD2_k127_7305940_5	118161.KB235922_gene366	9.179e-126	454.0	COG0652@1|root,COG1361@1|root,COG2133@1|root,COG3291@1|root,COG3506@1|root,COG0652@2|Bacteria,COG1361@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Cu_amine_oxidN1,DUF1349,GSDH,PKD,Pro_isomerase,fn3
HFD2_k127_731833_6	1146883.BLASA_5066	3.024e-31	130.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4ERBQ@85013|Frankiales	201174|Actinobacteria	M	Cell wall hydrolase autolysin	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
HFD2_k127_731833_4	1380356.JNIK01000020_gene1379	1.951e-38	148.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4ET42@85013|Frankiales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HFD2_k127_731833_0	1313172.YM304_42800	6.137e-149	482.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4CMUE@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_731833_8	1313172.YM304_42770	2.278e-07	61.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_731833_3	1313172.YM304_42760	1.77e-57	206.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_731833_2	1380393.JHVP01000013_gene3366	3.6e-60	229.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EX2B@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HFD2_k127_731833_1	1313172.YM304_42740	2.402e-107	359.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4CN2K@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HFD2_k127_731833_5	1313172.YM304_42730	1.934e-35	155.0	2B0G0@1|root,31STG@2|Bacteria,2HGDS@201174|Actinobacteria,4CNCA@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7380556_20	1268303.RHODMAR_1226	1.741e-09	63.0	2CSMT@1|root,32SRG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_7380556_3	526227.Mesil_2806	5.856e-115	375.0	COG1126@1|root,COG1126@2|Bacteria,1WI0Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HFD2_k127_7380556_8	266779.Meso_3148	2.923e-81	282.0	COG0765@1|root,COG0765@2|Bacteria,1N786@1224|Proteobacteria,2U10S@28211|Alphaproteobacteria,43ITH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Polar amino acid ABC transporter	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD2_k127_7380556_11	926560.KE387023_gene3703	8.767e-57	212.0	COG0834@1|root,COG0834@2|Bacteria,1WMI9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HFD2_k127_7380556_4	1313172.YM304_16090	2.407e-105	347.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4CN2G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HFD2_k127_7380556_6	1206732.BAGD01000095_gene4013	6.791e-100	342.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4FWB3@85025|Nocardiaceae	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_7380556_0	1313172.YM304_16080	0.0	1092.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CMSF@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,S1
HFD2_k127_7380556_14	1313172.YM304_16070	4.219e-32	127.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4CNBM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD2_k127_7380556_10	35754.JNYJ01000021_gene379	1.247e-59	215.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4DDRS@85008|Micromonosporales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_7380556_16	1123239.KB898623_gene1718	8.123e-18	96.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,4HF0T@91061|Bacilli	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_7380556_19	1205681.CALW02000030_gene947	5.397e-10	69.0	COG1605@1|root,COG1605@2|Bacteria,1MZTQ@1224|Proteobacteria,2UCMC@28211|Alphaproteobacteria,48U6E@772|Bartonellaceae	28211|Alphaproteobacteria	E	Chorismate mutase type II	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
HFD2_k127_7380556_7	1313172.YM304_39910	3.042e-88	314.0	COG0715@1|root,COG0715@2|Bacteria,2I93G@201174|Actinobacteria	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_7380556_2	1313172.YM304_16060	7.055e-135	436.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CN39@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HFD2_k127_7380556_5	1313172.YM304_15990	1.294e-101	341.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CN62@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD2_k127_7380556_13	1313172.YM304_15980	1.439e-36	147.0	COG0858@1|root,COG0858@2|Bacteria,2HGGX@201174|Actinobacteria,4CNEB@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HFD2_k127_7380556_17	28042.GU90_09365	2.394e-15	81.0	COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria,4E5G9@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HFD2_k127_7380556_9	1313172.YM304_15970	2.435e-68	238.0	COG3917@1|root,COG3917@2|Bacteria,2I2EX@201174|Actinobacteria,4CP5E@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7380556_1	525909.Afer_0638	1.381e-280	892.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CMS2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HFD2_k127_7380556_18	313589.JNB_20328	2.473e-10	66.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4FHW1@85021|Intrasporangiaceae	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HFD2_k127_7380556_15	1313172.YM304_15880	5.354e-25	106.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HFD2_k127_7389114_24	1229780.BN381_250067	6.215e-10	63.0	COG2025@1|root,COG2025@2|Bacteria,2IIKX@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_7389114_15	760192.Halhy_1179	3.595e-40	160.0	COG2329@1|root,COG2329@2|Bacteria,4NQGS@976|Bacteroidetes,1IYGS@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF3291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
HFD2_k127_7389114_11	1313172.YM304_33790	9.888e-68	236.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria,4CNDD@84992|Acidimicrobiia	84992|Acidimicrobiia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_7389114_9	1163617.SCD_n02041	3.172e-114	387.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HFD2_k127_7389114_10	1313172.YM304_41830	8.843e-68	233.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4CN54@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HFD2_k127_7389114_1	1229780.BN381_250079	0.0	1003.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	FAD_oxidored,Oxidored_FMN,Pyr_redox_2
HFD2_k127_7389114_7	1313172.YM304_36290	2.375e-145	473.0	COG0863@1|root,COG0863@2|Bacteria,2I9DJ@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HFD2_k127_7389114_5	1206731.BAGB01000041_gene8421	6.712e-158	514.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4FWHU@85025|Nocardiaceae	201174|Actinobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD2_k127_7389114_4	1313172.YM304_38950	2.278e-165	531.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria	201174|Actinobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HFD2_k127_7389114_23	1298863.AUEP01000011_gene515	2.524e-15	83.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DR64@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HFD2_k127_7389114_22	1206741.BAFX01000003_gene5425	1.355e-20	102.0	COG0664@1|root,COG0664@2|Bacteria,2IGTB@201174|Actinobacteria,4FZMD@85025|Nocardiaceae	201174|Actinobacteria	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_7389114_20	105420.BBPO01000075_gene4615	9.38e-29	121.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria,2NIHG@228398|Streptacidiphilus	201174|Actinobacteria	D	CrcB-like protein, Camphor Resistance (CrcB)	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HFD2_k127_7389114_14	1246448.ANAZ01000008_gene2407	5.734e-42	164.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria,4EK9R@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HFD2_k127_7389114_19	479433.Caci_7364	8.599e-30	128.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HFD2_k127_7389114_8	1313172.YM304_22190	2.555e-116	391.0	COG0038@1|root,COG0038@2|Bacteria,2HGV9@201174|Actinobacteria,4CNW2@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
HFD2_k127_7389114_16	106370.Francci3_2500	3.004e-38	148.0	COG1846@1|root,COG1846@2|Bacteria,2IKZU@201174|Actinobacteria,4ETIV@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HFD2_k127_7389114_0	1313172.YM304_36150	0.0	1030.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CMS6@84992|Acidimicrobiia	84992|Acidimicrobiia	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_7389114_13	1313172.YM304_36130	8.557e-48	175.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	fldA	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HFD2_k127_7389114_12	1313172.YM304_36110	1.995e-67	231.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia	84992|Acidimicrobiia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HFD2_k127_7389114_3	1313172.YM304_36100	2.188e-186	588.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4CMVM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HFD2_k127_7389114_6	1313172.YM304_36090	8.639e-157	503.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CMSK@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HFD2_k127_7389114_21	1313172.YM304_15590	6.997e-28	120.0	COG5340@1|root,COG5340@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
HFD2_k127_7389114_2	1313172.YM304_07240	1.766e-217	685.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4CMQ0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD2_k127_7417449_2	1380390.JIAT01000017_gene5358	1.016e-133	435.0	COG2141@1|root,COG2141@2|Bacteria,2IF10@201174|Actinobacteria,4CRN4@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7417449_4	1313172.YM304_25430	6.715e-113	375.0	COG0402@1|root,COG0402@2|Bacteria,2GKKM@201174|Actinobacteria	201174|Actinobacteria	F	cytosine deaminase	codA	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
HFD2_k127_7417449_7	477641.MODMU_1500	1.572e-87	295.0	COG1028@1|root,COG1028@2|Bacteria,2IJEQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_7417449_6	1380390.JIAT01000017_gene5355	5.193e-104	346.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4CRRY@84995|Rubrobacteria	84995|Rubrobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_7417449_8	1160137.KB907307_gene3170	7.68e-66	237.0	COG0600@1|root,COG0600@2|Bacteria,2IBTW@201174|Actinobacteria,4FYI1@85025|Nocardiaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_7417449_3	477641.MODMU_1491	6.638e-113	380.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria,4EUZ0@85013|Frankiales	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7417449_1	1313172.YM304_01600	1.132e-163	529.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4CN6K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD2_k127_7417449_5	1313172.YM304_25380	5.285e-108	365.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria	201174|Actinobacteria	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HFD2_k127_7417449_0	1313172.YM304_25370	7.262e-205	664.0	COG1233@1|root,COG1233@2|Bacteria,2IE6C@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	crtO	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_7417449_9	656024.FsymDg_2119	2.119e-35	136.0	COG0605@1|root,COG0605@2|Bacteria,2GJV8@201174|Actinobacteria,4EUBT@85013|Frankiales	201174|Actinobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD2_k127_7461663_27	861299.J421_5663	3.351e-07	63.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_7461663_13	1313172.YM304_37810	2.478e-85	298.0	COG1470@1|root,COG1470@2|Bacteria,2H4ZH@201174|Actinobacteria	201174|Actinobacteria	E	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,RicinB_lectin_2
HFD2_k127_7461663_21	263358.VAB18032_29656	6.707e-18	97.0	COG2199@1|root,COG2199@2|Bacteria,2I97W@201174|Actinobacteria,4D904@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_7461663_6	1229780.BN381_60037	1.33e-131	428.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,3UW8S@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Delta-aminolevulinic acid dehydratase	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HFD2_k127_7461663_3	1313172.YM304_37790	1.76e-175	561.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CMTZ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_7461663_10	1313172.YM304_04670	1.78e-92	317.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CN59@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA 2'-O ribose methyltransferase substrate binding	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_7461663_15	1313172.YM304_04660	2.616e-67	233.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CN4V@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HFD2_k127_7461663_16	1313172.YM304_04650	6.545e-63	243.0	COG1211@1|root,COG1211@2|Bacteria,2I767@201174|Actinobacteria	201174|Actinobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD2_k127_7461663_8	1313172.YM304_04640	4.581e-100	330.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K01420,ko:K10914,ko:K21561,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_7461663_24	1451261.AS96_04725	1.806e-11	75.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4FKD7@85023|Microbacteriaceae	201174|Actinobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	proX	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HFD2_k127_7461663_7	1079986.JH164837_gene5649	1.556e-128	418.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the peptidase S33 family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HFD2_k127_7461663_0	1313172.YM304_01580	0.0	1131.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD2_k127_7461663_4	298653.Franean1_4346	6.852e-169	566.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2GM1B@201174|Actinobacteria,4EWC9@85013|Frankiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_7461663_22	298653.Franean1_4345	2.261e-15	87.0	2C2P4@1|root,2ZCV6@2|Bacteria,2HCZ7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7461663_19	1150864.MILUP08_43756	3.317e-25	115.0	2E5KE@1|root,330BK@2|Bacteria,2IKV9@201174|Actinobacteria,4DGMY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7461663_14	397278.JOJN01000018_gene3515	4.711e-74	263.0	COG0577@1|root,COG0577@2|Bacteria,2HY9V@201174|Actinobacteria,4DTYD@85009|Propionibacteriales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HFD2_k127_7461663_11	196162.Noca_3776	6.794e-90	313.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	devC	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7461663_9	593907.Celgi_0134	1.88e-96	329.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4F1UP@85016|Cellulomonadaceae	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7461663_5	1150398.JIBJ01000012_gene2117	2.685e-159	509.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone reductase	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD2_k127_7461663_25	882082.SaccyDRAFT_2462	4.379e-10	64.0	COG3462@1|root,COG3462@2|Bacteria,2GWIQ@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7461663_26	2074.JNYD01000002_gene5610	3.585e-08	59.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HFD2_k127_7461663_2	1313172.YM304_04570	5.572e-226	746.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
HFD2_k127_7461663_1	928724.SacglDRAFT_03430	6.181e-255	809.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXGB@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HFD2_k127_7461663_23	443218.AS9A_2039	2.093e-14	77.0	COG2608@1|root,COG2608@2|Bacteria,2GQK5@201174|Actinobacteria,23BBK@1762|Mycobacteriaceae	201174|Actinobacteria	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
HFD2_k127_7461663_17	414996.IL38_12640	4.659e-29	119.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,409BI@622450|Actinopolysporales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HFD2_k127_7461663_12	338969.Rfer_0608	7.313e-89	297.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,4ACSW@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_7488022_11	909663.KI867150_gene2416	7.696e-25	106.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,42QH3@68525|delta/epsilon subdivisions,2WKXH@28221|Deltaproteobacteria,2MRW2@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7488022_1	1146883.BLASA_1529	9.752e-109	368.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4EUB2@85013|Frankiales	201174|Actinobacteria	J	Amidase	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_7488022_10	269796.Rru_A1945	7.774e-42	169.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,2JSEA@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_7488022_2	398525.KB900701_gene298	1.501e-105	362.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2TYHX@28211|Alphaproteobacteria,3JTNQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_7488022_13	1242864.D187_007392	1.497e-08	66.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD2_k127_7488022_5	1313172.YM304_07300	1.558e-79	281.0	COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria	201174|Actinobacteria	EGP	Drug resistance transporter, bcr cfla subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HFD2_k127_7488022_7	1298867.AUES01000040_gene980	8.543e-71	253.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria,3JX4C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_7488022_8	1121091.AUMP01000024_gene3029	1.408e-67	251.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HDHF@91061|Bacilli	91061|Bacilli	GT	Phosphotransferase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HFD2_k127_7488022_0	2074.JNYD01000001_gene6086	1.895e-164	527.0	COG0620@1|root,COG0620@2|Bacteria,2H8H4@201174|Actinobacteria,4E8PX@85010|Pseudonocardiales	201174|Actinobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD2_k127_7488022_4	463191.SSEG_10556	2.481e-81	289.0	COG0410@1|root,COG0410@2|Bacteria,2IB16@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_7488022_3	463191.SSEG_10555	7.108e-89	315.0	COG0411@1|root,COG0411@2|Bacteria,2I8N9@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_7488022_6	1380390.JIAT01000009_gene1441	4.072e-73	259.0	COG4177@1|root,COG4177@2|Bacteria,2IEMH@201174|Actinobacteria,4CTCB@84995|Rubrobacteria	84995|Rubrobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HFD2_k127_7488022_9	543632.JOJL01000017_gene9957	8.327e-66	236.0	COG0559@1|root,COG0559@2|Bacteria,2GJM0@201174|Actinobacteria,4DKFE@85008|Micromonosporales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_7488022_12	1380390.JIAT01000009_gene1443	2.376e-11	66.0	COG0683@1|root,COG0683@2|Bacteria,2GJ2V@201174|Actinobacteria,4CTNJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_7491500_3	472759.Nhal_2915	1.113e-98	327.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,1WW2S@135613|Chromatiales	135613|Chromatiales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD2_k127_7491500_5	693661.Arcve_0464	5.482e-21	100.0	COG3613@1|root,arCOG02434@2157|Archaea,2XZZI@28890|Euryarchaeota	28890|Euryarchaeota	F	Nucleoside 2-deoxyribosyltransferase like	-	-	2.4.2.6	ko:K08728	ko00240,map00240	-	R02806	RC00063	ko00000,ko00001,ko01000	-	-	-	Nuc_deoxyrib_tr
HFD2_k127_7491500_1	1313172.YM304_02580	2.351e-172	549.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD2_k127_7491500_4	1121363.KB902238_gene959	5.424e-28	129.0	29V0V@1|root,31YP4@2|Bacteria,2I035@201174|Actinobacteria,22QR0@1653|Corynebacteriaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_7491500_2	1313172.YM304_37240	6.225e-134	434.0	COG1409@1|root,COG1409@2|Bacteria,2IDNH@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Pur_ac_phosph_N
HFD2_k127_7491500_0	1313172.YM304_37200	2.417e-175	552.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_7495424_7	1313172.YM304_08260	2.186e-09	63.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CN29@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD2_k127_7495424_1	1313172.YM304_08250	2.251e-95	317.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CMZP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HFD2_k127_7495424_0	1229780.BN381_350018	2.039e-175	569.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,3UX33@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_7495424_5	1048339.KB913029_gene3873	1.899e-60	218.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4ESF8@85013|Frankiales	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_7495424_4	525909.Afer_1924	4.271e-64	232.0	COG0569@1|root,COG0569@2|Bacteria,2HH1S@201174|Actinobacteria,4CP21@84992|Acidimicrobiia	84992|Acidimicrobiia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HFD2_k127_7495424_6	1306174.JODP01000013_gene7771	3.984e-11	72.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7495424_3	1313172.YM304_27130	3.067e-80	279.0	COG5285@1|root,COG5285@2|Bacteria,2IF9U@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_7495424_2	1313172.YM304_08190	8.826e-89	305.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_7563793_10	266779.Meso_3148	3.216e-72	248.0	COG0765@1|root,COG0765@2|Bacteria,1N786@1224|Proteobacteria,2U10S@28211|Alphaproteobacteria,43ITH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Polar amino acid ABC transporter	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD2_k127_7563793_7	526227.Mesil_2806	2.509e-116	379.0	COG1126@1|root,COG1126@2|Bacteria,1WI0Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HFD2_k127_7563793_11	1121271.AUCM01000003_gene1318	1.927e-32	133.0	2CSMT@1|root,32SRG@2|Bacteria,1N0NU@1224|Proteobacteria,2UBXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD2_k127_7563793_12	1089545.KB913037_gene6185	5.497e-17	88.0	COG1309@1|root,COG1309@2|Bacteria,2GKYG@201174|Actinobacteria,4E132@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_7563793_4	1229780.BN381_80295	1.06e-157	505.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HFD2_k127_7563793_5	1313172.YM304_42280	8.603e-130	422.0	COG4638@1|root,COG4638@2|Bacteria,2IC5G@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD2_k127_7563793_0	1313172.YM304_42130	4.117e-213	670.0	COG0402@1|root,COG0402@2|Bacteria,2I9BJ@201174|Actinobacteria,4CN7U@84992|Acidimicrobiia	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_7563793_9	1313172.YM304_42160	3.002e-73	248.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7563793_2	1313172.YM304_42060	3.256e-165	526.0	COG0500@1|root,COG2226@2|Bacteria,2GRM0@201174|Actinobacteria	201174|Actinobacteria	Q	o-methyltransferase	-	-	2.1.1.302	ko:K21377	-	-	-	-	ko00000,ko01000	-	-	-	Dimerisation2,Methyltransf_2
HFD2_k127_7563793_3	1313172.YM304_42070	1.509e-162	524.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4CNGR@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_7563793_8	1313172.YM304_42180	9.245e-100	334.0	COG1079@1|root,COG1079@2|Bacteria,2I97H@201174|Actinobacteria	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_7563793_6	1313172.YM304_42190	9.511e-125	410.0	COG4603@1|root,COG4603@2|Bacteria,2IAAG@201174|Actinobacteria	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_7563793_1	1313172.YM304_42200	1.078e-199	633.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4CP5I@84992|Acidimicrobiia	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_7576636_2	1313172.YM304_02490	2.516e-100	339.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CN0G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HFD2_k127_7576636_12	1313172.YM304_13800	2.983e-50	193.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4CNAH@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HFD2_k127_7576636_18	47839.CCAU010000013_gene4849	2.675e-14	81.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria,23DDH@1762|Mycobacteriaceae	201174|Actinobacteria	HT	Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD2_k127_7576636_11	1192034.CAP_7905	3.368e-61	222.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2YUU1@29|Myxococcales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD2_k127_7576636_5	1121926.AXWO01000004_gene998	3.302e-83	296.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4EY4C@85014|Glycomycetales	201174|Actinobacteria	S	Protein of unknown function DUF111	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD2_k127_7576636_6	1120944.JONS01000046_gene2491	1.355e-78	271.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4D6A7@85005|Actinomycetales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD2_k127_7576636_9	1313172.YM304_02460	3.047e-69	261.0	COG1131@1|root,COG1131@2|Bacteria,2IJGC@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	ccmA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7576636_17	1313172.YM304_02450	3.092e-17	89.0	2DH1Q@1|root,2ZY32@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
HFD2_k127_7576636_0	1313172.YM304_02440	1.084e-219	692.0	COG2146@1|root,COG2220@1|root,COG2146@2|Bacteria,COG2220@2|Bacteria,2GP4N@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K14952	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	Lactamase_B_3,Rieske
HFD2_k127_7576636_22	1463825.JNXC01000020_gene6607	0.0004234	51.0	2C2NP@1|root,334Y5@2|Bacteria,2IDXP@201174|Actinobacteria,4E42Q@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7576636_4	1313172.YM304_02380	4.785e-86	297.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HFD2_k127_7576636_20	6211.A0A068Y4T3	1.978e-11	72.0	KOG1971@1|root,KOG1971@2759|Eukaryota,38DIW@33154|Opisthokonta,3BCUS@33208|Metazoa,3CS3C@33213|Bilateria	33208|Metazoa	O	procollagen-lysine 5-dioxygenase activity	PLOD1	GO:0000003,GO:0000902,GO:0000904,GO:0001666,GO:0001701,GO:0001885,GO:0001886,GO:0002009,GO:0002064,GO:0003006,GO:0003008,GO:0003013,GO:0003018,GO:0003158,GO:0003382,GO:0003674,GO:0003824,GO:0003980,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005791,GO:0005794,GO:0005802,GO:0006011,GO:0006082,GO:0006139,GO:0006464,GO:0006486,GO:0006493,GO:0006520,GO:0006575,GO:0006725,GO:0006793,GO:0006807,GO:0006950,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007295,GO:0007399,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008194,GO:0008198,GO:0008378,GO:0008475,GO:0008544,GO:0008652,GO:0009058,GO:0009059,GO:0009066,GO:0009067,GO:0009100,GO:0009101,GO:0009225,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009987,GO:0010033,GO:0012505,GO:0016020,GO:0016043,GO:0016053,GO:0016491,GO:0016705,GO:0016706,GO:0016740,GO:0016757,GO:0016758,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0019842,GO:0019953,GO:0021915,GO:0022412,GO:0022414,GO:0022607,GO:0030154,GO:0030198,GO:0030199,GO:0030246,GO:0030323,GO:0030324,GO:0030855,GO:0030867,GO:0031012,GO:0031090,GO:0031406,GO:0031418,GO:0031984,GO:0032501,GO:0032502,GO:0032504,GO:0032870,GO:0032963,GO:0032964,GO:0032989,GO:0032991,GO:0033036,GO:0033218,GO:0033823,GO:0034641,GO:0034645,GO:0035150,GO:0035250,GO:0035251,GO:0035295,GO:0035296,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042175,GO:0042221,GO:0042277,GO:0042311,GO:0042398,GO:0042802,GO:0042803,GO:0043009,GO:0043062,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045446,GO:0046394,GO:0046483,GO:0046527,GO:0046872,GO:0046914,GO:0046946,GO:0046947,GO:0046983,GO:0048029,GO:0048037,GO:0048468,GO:0048471,GO:0048477,GO:0048513,GO:0048589,GO:0048609,GO:0048729,GO:0048730,GO:0048731,GO:0048856,GO:0048869,GO:0050211,GO:0050662,GO:0050880,GO:0050896,GO:0051179,GO:0051213,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060425,GO:0060429,GO:0060541,GO:0062023,GO:0065007,GO:0065008,GO:0070085,GO:0070482,GO:0070815,GO:0070831,GO:0070887,GO:0071310,GO:0071495,GO:0071704,GO:0071711,GO:0071840,GO:0090066,GO:0097359,GO:0097435,GO:0097746,GO:0097755,GO:0098588,GO:0098791,GO:0098827,GO:0140096,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	1.14.11.4,2.4.1.50,2.4.1.66	ko:K00473,ko:K13645,ko:K13646,ko:K13647,ko:K15174	ko00310,ko00514,ko04011,map00310,map00514,map04011	-	R03376,R03380,R04491	RC00005,RC00049,RC00397,RC00709	ko00000,ko00001,ko01000,ko01003,ko03021,ko04147	-	-	-	2OG-FeII_Oxy
HFD2_k127_7576636_3	469383.Cwoe_4726	1.095e-98	331.0	COG0008@1|root,COG0008@2|Bacteria,2GKMT@201174|Actinobacteria,4CP7F@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD2_k127_7576636_7	1336235.JAEG01000005_gene3584	3.926e-73	275.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
HFD2_k127_7576636_15	926554.KI912640_gene1327	2.969e-29	126.0	COG1495@1|root,COG1495@2|Bacteria,1WKBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Required for disulfide bond formation in some proteins	-	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HFD2_k127_7576636_14	1313172.YM304_02480	2.823e-32	141.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7576636_8	1122939.ATUD01000006_gene1595	9.296e-71	259.0	COG0179@1|root,COG0684@1|root,COG0179@2|Bacteria,COG0684@2|Bacteria,2GN1K@201174|Actinobacteria,4CPUK@84995|Rubrobacteria	84995|Rubrobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,RraA-like
HFD2_k127_7576636_16	1003200.AXXA_27005	1.017e-25	112.0	COG0251@1|root,COG0251@2|Bacteria,1RB9R@1224|Proteobacteria,2VRZG@28216|Betaproteobacteria,3T48Z@506|Alcaligenaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_7576636_10	1248916.ANFY01000007_gene2525	6.225e-66	233.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TUWC@28211|Alphaproteobacteria,2K2Q1@204457|Sphingomonadales	204457|Sphingomonadales	Q	hydratase	-	-	-	ko:K02509	ko00350,ko01120,map00350,map01120	-	R04132,R06897	RC01615,RC02595	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_7576636_13	2002.JOEQ01000021_gene6742	1.057e-36	145.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria,4EJZ6@85012|Streptosporangiales	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HFD2_k127_7576636_21	1313172.YM304_38360	7.26e-10	69.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,FG-GAP,Flg_new,Laminin_G_3,Lipase_GDSL_2,M60-like_N,PA14,Peptidase_M60
HFD2_k127_7667121_3	1313172.YM304_38180	1.305e-74	260.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CN5H@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HFD2_k127_7667121_1	1313172.YM304_38170	4.424e-116	392.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4CN0P@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HFD2_k127_7667121_8	1313172.YM304_41120	9.731e-38	146.0	COG0745@1|root,COG0745@2|Bacteria	1313172.YM304_41120|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7667121_12	1122611.KB903939_gene622	2.224e-05	55.0	COG1366@1|root,COG1366@2|Bacteria,2I0EP@201174|Actinobacteria,4EQH2@85012|Streptosporangiales	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
HFD2_k127_7667121_6	1237500.ANBA01000020_gene3233	8.426e-62	225.0	COG2203@1|root,COG2203@2|Bacteria,2HGVH@201174|Actinobacteria,4EJDR@85012|Streptosporangiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
HFD2_k127_7667121_7	469383.Cwoe_3147	6.751e-42	163.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
HFD2_k127_7667121_2	1313172.YM304_18790	1.205e-99	332.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria,4CNAF@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_7667121_0	485913.Krac_12078	1.363e-219	713.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Pro-kuma_activ
HFD2_k127_7667121_10	928724.SacglDRAFT_01978	1.297e-13	78.0	COG3173@1|root,COG3173@2|Bacteria,2I35I@201174|Actinobacteria,4E4R5@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	2.1.1.179	ko:K18844,ko:K18845	-	-	-	-	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	APH
HFD2_k127_7667121_9	468556.AQYG01000045_gene1908	7.225e-37	143.0	COG3070@1|root,COG3070@2|Bacteria,2IKKV@201174|Actinobacteria,4GERC@85026|Gordoniaceae	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
HFD2_k127_7667121_11	479433.Caci_4854	5.121e-09	62.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749,ko:K17763,ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko03021	-	-	-	STAS,STAS_2
HFD2_k127_7667121_4	44060.JODL01000027_gene115	1.503e-70	258.0	COG0262@1|root,COG0262@2|Bacteria,2GK32@201174|Actinobacteria	201174|Actinobacteria	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD2_k127_7667121_5	1394178.AWOO02000008_gene3023	4.92e-63	223.0	2F7C9@1|root,33ZTB@2|Bacteria,2H6WW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7707812_7	1054860.KB913030_gene2331	5.702e-08	64.0	COG3764@1|root,COG3764@2|Bacteria,2GNA2@201174|Actinobacteria	201174|Actinobacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HFD2_k127_7707812_4	1313172.YM304_28930	1.022e-45	175.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	ydjA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_7707812_6	1205680.CAKO01000004_gene3614	4.312e-10	69.0	COG5424@1|root,COG5424@2|Bacteria,1PVPF@1224|Proteobacteria,2U38I@28211|Alphaproteobacteria,2JYA4@204441|Rhodospirillales	204441|Rhodospirillales	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HFD2_k127_7707812_3	208444.JNYY01000009_gene3621	1.094e-77	271.0	COG2021@1|root,COG2021@2|Bacteria,2I3NA@201174|Actinobacteria,4DZ1P@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD2_k127_7707812_2	1035308.AQYY01000001_gene1663	2.058e-85	291.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	hhoA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_7707812_5	1035308.AQYY01000001_gene1662	2.834e-35	139.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD2_k127_7707812_0	1003195.SCAT_1080	4.856e-122	398.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
HFD2_k127_7707812_1	1313172.YM304_28830	4.318e-98	324.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CMX2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_77741_0	1385518.N798_09360	6.098e-104	383.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2I3CQ@201174|Actinobacteria,4FK1F@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
HFD2_k127_77741_2	1157634.KB912968_gene6579	1.227e-10	70.0	COG1595@1|root,COG1595@2|Bacteria,2H5T5@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sig46	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_77741_4	1122602.ATXP01000021_gene139	0.000958	45.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_77741_1	298653.Franean1_4224	7.482e-77	268.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria,4ETX9@85013|Frankiales	201174|Actinobacteria	P	PFAM Inositol monophosphatase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HFD2_k127_77741_3	1219045.BV98_001673	0.0004082	44.0	COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,2TW4Z@28211|Alphaproteobacteria,2K0RH@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD2_k127_7910352_29	28072.Nos7524_5216	9.117e-12	74.0	COG1216@1|root,COG1216@2|Bacteria,1G09N@1117|Cyanobacteria,1HUB2@1161|Nostocales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
HFD2_k127_7910352_30	411459.RUMOBE_02806	3.17e-05	56.0	COG2244@1|root,COG2244@2|Bacteria,1TP7R@1239|Firmicutes,24AD0@186801|Clostridia,3XZYN@572511|Blautia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HFD2_k127_7910352_26	1463901.JOIY01000016_gene6548	4.696e-24	115.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
HFD2_k127_7910352_15	1120949.KB903294_gene3659	6.576e-65	235.0	2ART5@1|root,31H4G@2|Bacteria,2I83W@201174|Actinobacteria,4DIX7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7910352_9	1116472.MGMO_204c00060	1.429e-87	301.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,1S5T5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD2_k127_7910352_0	1116472.MGMO_204c00050	2.038e-207	657.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,1RPYU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	homoserine dehydrogenase	strU	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3
HFD2_k127_7910352_13	414684.RC1_3995	2.182e-71	249.0	COG2120@1|root,COG2120@2|Bacteria,1MX2V@1224|Proteobacteria,2TT5F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_7910352_4	298653.Franean1_6561	1.365e-130	426.0	COG0451@1|root,COG0451@2|Bacteria,2GNYX@201174|Actinobacteria,4ETSW@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_7910352_6	1116472.MGMO_204c00040	1.095e-111	367.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,1RNWP@1236|Gammaproteobacteria,1XGFN@135618|Methylococcales	135618|Methylococcales	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
HFD2_k127_7910352_17	765420.OSCT_0015	2.928e-57	205.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
HFD2_k127_7910352_7	1313172.YM304_14490	1.214e-109	368.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	epsO	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
HFD2_k127_7910352_10	1313172.YM304_14500	3.101e-83	296.0	COG1922@1|root,COG1922@2|Bacteria,2IFW3@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
HFD2_k127_7910352_18	1313172.YM304_14510	1.034e-47	184.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16692,ko:K20998	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	CbiA,Wzz
HFD2_k127_7910352_23	1313172.YM304_14530	1.487e-40	165.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	pslE	-	-	ko:K20998	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	AAA_31
HFD2_k127_7910352_3	1313172.YM304_14540	9.346e-133	446.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847,ko:K02849,ko:K21003	ko00540,ko01100,ko02025,map00540,map01100,map02025	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko02000	9.B.67.4,9.B.67.5	GT9	-	Glyco_transf_25,Wzy_C
HFD2_k127_7910352_5	1313172.YM304_14560	5.581e-114	377.0	COG0438@1|root,COG0438@2|Bacteria,2GQ6S@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HFD2_k127_7910352_12	1121272.KB903249_gene1831	4.946e-79	274.0	COG1595@1|root,COG1595@2|Bacteria,2GJ21@201174|Actinobacteria,4D9HP@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	sig20	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_cc,Sigma70_r2
HFD2_k127_7910352_11	1229780.BN381_450018	3.388e-80	289.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,3UXA2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD2_k127_7910352_24	1229780.BN381_80116	1.205e-39	151.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,3UXRV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	JAB/MPN domain	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HFD2_k127_7910352_21	525909.Afer_1754	5.813e-42	167.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4CN4T@84992|Acidimicrobiia	84992|Acidimicrobiia	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HFD2_k127_7910352_20	1313172.YM304_13280	1.431e-42	168.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	Peptidase_M14
HFD2_k127_7910352_25	1283283.ATXA01000005_gene2104	3.698e-35	138.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_7910352_22	710696.Intca_3543	2.455e-41	156.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,4FJCM@85021|Intrasporangiaceae	201174|Actinobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_7910352_19	1114959.SZMC14600_10328	1.742e-43	162.0	COG5207@1|root,COG5207@2|Bacteria,2IKW9@201174|Actinobacteria,4E5S8@85010|Pseudonocardiales	201174|Actinobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HFD2_k127_7910352_2	66869.JNXG01000001_gene3698	5.694e-135	445.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,419QG@629295|Streptomyces griseus group	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7910352_16	298653.Franean1_6971	1.521e-58	210.0	COG3193@1|root,COG3193@2|Bacteria,2IK20@201174|Actinobacteria,4EVGY@85013|Frankiales	201174|Actinobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_7910352_8	1380394.JADL01000004_gene5779	5.244e-99	331.0	COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2U0FP@28211|Alphaproteobacteria,2JQWR@204441|Rhodospirillales	204441|Rhodospirillales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_7910352_28	700598.Niako_0782	1.483e-12	71.0	COG2207@1|root,COG2207@2|Bacteria,4NVDF@976|Bacteroidetes,1IU6I@117747|Sphingobacteriia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7910352_14	1122622.ATWJ01000009_gene3111	1.91e-67	251.0	2CVPW@1|root,32SXZ@2|Bacteria,2ITC5@201174|Actinobacteria,4FIRU@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7910352_31	1229780.BN381_250015	0.0009685	48.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_7910352_1	1229780.BN381_80377	1.637e-160	518.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
HFD2_k127_797486_37	526225.Gobs_0360	3.64e-06	58.0	COG3173@1|root,COG3173@2|Bacteria,2H3VQ@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_797486_8	35754.JNYJ01000037_gene4668	1.476e-130	450.0	COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4DBBC@85008|Micromonosporales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
HFD2_k127_797486_11	1120936.KB907216_gene3737	4.929e-119	409.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4EGRW@85012|Streptosporangiales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HFD2_k127_797486_29	1306174.JODP01000003_gene1783	2.608e-40	164.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
HFD2_k127_797486_20	1155718.KB891853_gene3810	2.963e-60	213.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HFD2_k127_797486_9	1123024.AUII01000036_gene3151	6.568e-126	423.0	COG1275@1|root,COG1275@2|Bacteria,2GK0D@201174|Actinobacteria	201174|Actinobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	SLAC1
HFD2_k127_797486_25	1229780.BN381_100090	5.723e-43	169.0	COG0723@1|root,COG0723@2|Bacteria,2I02M@201174|Actinobacteria	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD2_k127_797486_14	1229780.BN381_100091	1.556e-95	320.0	COG0437@1|root,COG0437@2|Bacteria,2I2DV@201174|Actinobacteria	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11
HFD2_k127_797486_0	1229780.BN381_100092	0.0	1186.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_797486_6	1229780.BN381_100093	7.288e-136	440.0	COG2223@1|root,COG2223@2|Bacteria,2ICXH@201174|Actinobacteria	201174|Actinobacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_797486_21	1179773.BN6_66610	4.678e-60	217.0	COG2141@1|root,COG2141@2|Bacteria,2I29H@201174|Actinobacteria,4E6ZP@85010|Pseudonocardiales	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_797486_12	469371.Tbis_0066	1.521e-106	362.0	COG2059@1|root,COG2059@2|Bacteria,2IB69@201174|Actinobacteria,4EC0D@85010|Pseudonocardiales	201174|Actinobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_797486_23	101510.RHA1_ro05939	1.108e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,2IQE0@201174|Actinobacteria,4G2CY@85025|Nocardiaceae	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_797486_34	1463825.JNXC01000002_gene4505	5.739e-29	123.0	COG0431@1|root,COG0431@2|Bacteria,2GMA7@201174|Actinobacteria,4E63V@85010|Pseudonocardiales	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HFD2_k127_797486_2	1122138.AQUZ01000049_gene2367	4.263e-273	849.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DNX7@85009|Propionibacteriales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_797486_33	1123322.KB904698_gene4698	1.87e-35	156.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HFD2_k127_797486_27	1123504.JQKD01000005_gene4883	1.584e-41	164.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VWVG@28216|Betaproteobacteria,4AGBZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_797486_1	1123229.AUBC01000003_gene2054	1.699e-310	967.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,3JQN2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HFD2_k127_797486_17	1449126.JQKL01000002_gene1587	1.497e-72	268.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HFD2_k127_797486_30	321327.CYA_2734	3.644e-40	169.0	COG2086@1|root,COG2086@2|Bacteria,1GBI7@1117|Cyanobacteria,1H2F0@1129|Synechococcus	1117|Cyanobacteria	C	Electron transfer flavoprotein, beta subunit FixA family protein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_797486_38	929712.KI912613_gene60	1.808e-05	57.0	COG0392@1|root,COG0392@2|Bacteria,2HNWB@201174|Actinobacteria,4CQ5E@84995|Rubrobacteria	84995|Rubrobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD2_k127_797486_3	101510.RHA1_ro06944	1.809e-176	565.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FU1R@85025|Nocardiaceae	201174|Actinobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_797486_19	1229780.BN381_470022	3.891e-67	238.0	COG0730@1|root,COG0730@2|Bacteria,2HGFU@201174|Actinobacteria,3UXNM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HFD2_k127_797486_35	1229780.BN381_130242	2.156e-26	113.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,3UWY5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
HFD2_k127_797486_18	335543.Sfum_1521	1.382e-67	238.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WSRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_797486_31	390989.JOEG01000009_gene1044	4.399e-40	156.0	COG1802@1|root,COG1802@2|Bacteria,2H1S8@201174|Actinobacteria,4DM6D@85008|Micromonosporales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_797486_16	1121033.AUCF01000032_gene2622	2.338e-88	314.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2JPDU@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_797486_7	1116369.KB890024_gene228	1.611e-135	441.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2U1HV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HFD2_k127_797486_10	1116369.KB890024_gene229	4.974e-122	412.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_797486_15	1122132.AQYH01000007_gene1997	1.305e-90	322.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria,4BMGF@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_797486_13	1116369.KB890024_gene231	1.023e-95	323.0	COG0601@1|root,COG0601@2|Bacteria,1MW3U@1224|Proteobacteria,2TUR2@28211|Alphaproteobacteria,43P07@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_797486_4	1116369.KB890024_gene232	9.052e-160	520.0	COG0747@1|root,COG0747@2|Bacteria,1PHCN@1224|Proteobacteria,2TV1F@28211|Alphaproteobacteria,43PJE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_797486_24	326424.FRAAL6172	3.706e-43	170.0	COG1802@1|root,COG1802@2|Bacteria,2IDZ6@201174|Actinobacteria,4ET86@85013|Frankiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_797486_28	479434.Sthe_3439	3.099e-41	164.0	COG1028@1|root,COG1028@2|Bacteria,2G8II@200795|Chloroflexi,27XKN@189775|Thermomicrobia	200795|Chloroflexi	IQ	Dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_797486_5	1429046.RR21198_3070	4.11e-143	470.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria,4FW58@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD2_k127_797486_26	1380394.JADL01000010_gene4275	1.253e-41	166.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,2U7XA@28211|Alphaproteobacteria,2JU6J@204441|Rhodospirillales	204441|Rhodospirillales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_797486_32	1121127.JAFA01000015_gene6297	1.452e-39	162.0	COG2423@1|root,COG2423@2|Bacteria,1RAMV@1224|Proteobacteria,2VJ8R@28216|Betaproteobacteria,1KI4D@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD2_k127_797486_36	1179773.BN6_38110	8.747e-12	77.0	COG0477@1|root,COG2814@2|Bacteria,2GK8C@201174|Actinobacteria,4DYDU@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.65	-	-	MFS_1,Sugar_tr
HFD2_k127_797486_22	1068978.AMETH_6042	1.43e-57	209.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria	201174|Actinobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_7977966_8	1313172.YM304_19410	3.55e-59	215.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4CN0Q@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_7977966_3	1313172.YM304_19420	6.625e-145	478.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CNID@84992|Acidimicrobiia	84992|Acidimicrobiia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	-	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7977966_2	1313172.YM304_19430	4.121e-150	483.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CMYF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD2_k127_7977966_4	1313172.YM304_19440	8.81e-128	438.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CN07@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_7977966_5	1313172.YM304_19450	5.394e-118	395.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4CN6S@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_7977966_6	1313172.YM304_19460	4.48e-108	361.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CNB3@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD2_k127_7977966_0	1313172.YM304_19470	2.959e-203	652.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4CMTG@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7977966_7	1313172.YM304_19480	1.347e-91	332.0	COG0812@1|root,COG0812@2|Bacteria,2HG0Y@201174|Actinobacteria,4CMXR@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD2_k127_7977966_11	1313172.YM304_19490	1.076e-49	195.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
HFD2_k127_7977966_1	1313172.YM304_19500	7.174e-183	577.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CMR8@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD2_k127_7977966_9	1313172.YM304_19520	2.662e-57	217.0	COG0325@1|root,COG0325@2|Bacteria,2HGAF@201174|Actinobacteria,4CN9H@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Alanine racemase, N-terminal domain	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HFD2_k127_7977966_10	1313172.YM304_19530	3.847e-52	192.0	COG1799@1|root,COG1799@2|Bacteria,2HGHD@201174|Actinobacteria,4CNES@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
HFD2_k127_7977966_12	1313172.YM304_19540	5.213e-14	74.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
HFD2_k127_7995482_12	1120950.KB892821_gene689	1.202e-95	317.0	COG0346@1|root,COG0346@2|Bacteria,2GMTB@201174|Actinobacteria,4DQN4@85009|Propionibacteriales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7995482_26	1121946.AUAX01000004_gene955	1.675e-49	188.0	COG3173@1|root,COG3173@2|Bacteria,2GKUE@201174|Actinobacteria,4DFUR@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_7995482_30	106370.Francci3_3407	6.642e-39	160.0	COG1503@1|root,COG1503@2|Bacteria,2GNN3@201174|Actinobacteria,4EVI4@85013|Frankiales	201174|Actinobacteria	J	translation release factor activity	-	GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
HFD2_k127_7995482_18	479432.Sros_7044	4.845e-85	306.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria,4EHF8@85012|Streptosporangiales	201174|Actinobacteria	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD2_k127_7995482_31	1313172.YM304_32820	1.341e-29	122.0	2CK2C@1|root,2ZY21@2|Bacteria,2HE72@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7995482_10	1313172.YM304_32840	5.636e-108	359.0	COG1468@1|root,COG1468@2|Bacteria,2HE3R@201174|Actinobacteria,4CP30@84992|Acidimicrobiia	84992|Acidimicrobiia	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HFD2_k127_7995482_43	1283287.KB822578_gene2482	0.0005888	50.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,4DRAD@85009|Propionibacteriales	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD2_k127_7995482_3	479434.Sthe_2440	1.096e-164	542.0	COG1505@1|root,COG1505@2|Bacteria,2GBNH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_7995482_8	1394178.AWOO02000093_gene8076	1.739e-122	409.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4EGUG@85012|Streptosporangiales	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
HFD2_k127_7995482_42	43354.JOIJ01000005_gene2241	0.0002423	53.0	COG4932@1|root,COG4932@2|Bacteria,2H7EZ@201174|Actinobacteria,4DZM7@85010|Pseudonocardiales	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7995482_14	526225.Gobs_0036	1.433e-90	315.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4ESG4@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_7995482_2	1313172.YM304_32970	1.895e-180	570.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4CMT9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Protein of unknown function (DUF933)	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD2_k127_7995482_34	1120936.KB907217_gene3505	2.216e-22	106.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4EHAG@85012|Streptosporangiales	201174|Actinobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_7995482_35	390989.JOEG01000004_gene3965	6.543e-19	89.0	COG3620@1|root,COG3620@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07467	-	-	-	-	ko00000	-	-	-	HTH_3,HTH_31
HFD2_k127_7995482_39	640132.Srot_0016	6.894e-06	55.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
HFD2_k127_7995482_7	591158.SSMG_01854	8.636e-152	499.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD2_k127_7995482_32	365046.Rta_21330	4.739e-29	120.0	COG2329@1|root,COG2329@2|Bacteria,1QTY7@1224|Proteobacteria,2WGHG@28216|Betaproteobacteria,4AJJR@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_7995482_11	1048339.KB913029_gene2111	1.531e-96	323.0	COG1396@1|root,COG1396@2|Bacteria,2GK1R@201174|Actinobacteria,4EV5Y@85013|Frankiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HFD2_k127_7995482_36	760192.Halhy_1163	2.648e-18	96.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_7995482_6	246196.MSMEI_0644	5.807e-158	512.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,23EUD@1762|Mycobacteriaceae	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_7995482_9	1429916.X566_16325	1.148e-116	391.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,3JWEQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_7995482_23	1313172.YM304_41750	1.991e-55	203.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HFD2_k127_7995482_29	1313172.YM304_32980	7.028e-41	154.0	COG1430@1|root,COG1430@2|Bacteria,2IKSE@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD2_k127_7995482_17	1313172.YM304_32990	1.142e-88	300.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4CNAK@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD2_k127_7995482_13	1313172.YM304_33000	1.573e-95	321.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4CN1K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD2_k127_7995482_1	1313172.YM304_33020	1.687e-255	795.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4CMP6@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
HFD2_k127_7995482_16	1313172.YM304_33030	9.262e-90	322.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CN2X@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD2_k127_7995482_15	1313172.YM304_33050	5.726e-90	320.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD2_k127_7995482_19	1313172.YM304_33060	3.887e-81	287.0	COG1947@1|root,COG1947@2|Bacteria,2HG8Y@201174|Actinobacteria,4CN6Y@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD2_k127_7995482_41	1132441.KI519454_gene297	8.835e-05	54.0	COG3409@1|root,COG4249@1|root,COG3409@2|Bacteria,COG4249@2|Bacteria,2IB3R@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_C14
HFD2_k127_7995482_24	1229780.BN381_60056	1.05e-53	197.0	COG1670@1|root,COG1670@2|Bacteria,2IS6V@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_7995482_20	1313172.YM304_06560	5.596e-78	275.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
HFD2_k127_7995482_33	55952.BU52_05125	7.652e-27	120.0	COG2045@1|root,COG2045@2|Bacteria,2GXP6@201174|Actinobacteria	201174|Actinobacteria	H	2-phosphosulpholactate phosphatase	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HFD2_k127_7995482_28	1463917.JODC01000042_gene2575	4.034e-48	190.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7995482_5	1313172.YM304_33080	6.595e-163	521.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4CMZA@84992|Acidimicrobiia	84992|Acidimicrobiia	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HFD2_k127_7995482_4	1313172.YM304_33090	3.807e-164	526.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CMVQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD2_k127_7995482_27	1313172.YM304_33100	8.434e-49	182.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4CNB1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	rplY	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD2_k127_7995482_22	1313172.YM304_33110	3.679e-67	234.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4CN75@84992|Acidimicrobiia	84992|Acidimicrobiia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD2_k127_7995482_25	1123023.JIAI01000001_gene6964	1.146e-49	188.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4E0A8@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_7995482_0	469371.Tbis_3135	4.31e-317	1007.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4DXZU@85010|Pseudonocardiales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD2_k127_7995482_21	1313172.YM304_33140	3.659e-76	261.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
HFD2_k127_8028024_5	1313172.YM304_42220	3.656e-86	300.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_8028024_11	1385520.N802_12465	7.143e-16	85.0	2A3IB@1|root,30S19@2|Bacteria,2H6TD@201174|Actinobacteria,4FJCD@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8028024_9	1385518.N798_01345	3.672e-45	179.0	2F7D1@1|root,33ZU2@2|Bacteria,2ITDT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8028024_8	1122138.AQUZ01000036_gene5466	1.49e-47	181.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_8028024_0	246196.MSMEI_2406	1.423e-269	846.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,23687@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD2_k127_8028024_7	1313172.YM304_41590	1.531e-73	253.0	COG0218@1|root,COG0218@2|Bacteria	2|Bacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HFD2_k127_8028024_3	266117.Rxyl_2783	4.88e-106	376.0	COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
HFD2_k127_8028024_1	1313172.YM304_39140	3.924e-219	736.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	Autotransporter,CHU_C,He_PIG,Lactonase,Laminin_G_3
HFD2_k127_8028024_6	1313172.YM304_39090	1.877e-75	279.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,LRR_5,Transglut_core
HFD2_k127_8028024_4	1313172.YM304_39080	4.769e-90	310.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4CP1F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_8028024_2	1313172.YM304_39070	1.551e-141	455.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_8028024_10	749414.SBI_02218	2.423e-44	183.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
HFD2_k127_8069472_8	358823.DF19_32420	1.542e-48	177.0	COG0666@1|root,COG0666@2|Bacteria,2I9A2@201174|Actinobacteria	201174|Actinobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
HFD2_k127_8069472_4	2074.JNYD01000016_gene4127	8.245e-92	311.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4DZ4E@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_8069472_3	292459.STH518	7.327e-123	417.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_8069472_7	523841.HFX_2326	3.795e-54	207.0	COG4826@1|root,arCOG04933@2157|Archaea,2XV8M@28890|Euryarchaeota,23UA2@183963|Halobacteria	183963|Halobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HFD2_k127_8069472_9	66429.JOFL01000011_gene2519	7.287e-46	178.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_8069472_0	935840.JAEQ01000007_gene3881	1.534e-173	552.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,43H8Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_8069472_2	1410619.SRDD_43130	2.019e-142	478.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,3ZZS6@613|Serratia	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	ADH_N,ADH_zinc_N
HFD2_k127_8069472_5	1246445.ANAY01000003_gene2980	1.774e-61	226.0	COG2175@1|root,COG2175@2|Bacteria,2I53F@201174|Actinobacteria	201174|Actinobacteria	Q	Protein of unknown function (DUF971)	-	-	1.14.11.1	ko:K00471	ko00310,map00310	-	R02397	RC00709	ko00000,ko00001,ko01000	-	-	-	DUF971,TauD
HFD2_k127_8069472_10	335541.Swol_2109	2.615e-08	65.0	COG0697@1|root,COG0697@2|Bacteria,1TR1G@1239|Firmicutes,24DN8@186801|Clostridia,42K8Y@68298|Syntrophomonadaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_8069472_1	44060.JODL01000002_gene2071	2.999e-161	519.0	COG5285@1|root,COG5285@2|Bacteria,2GNTX@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HFD2_k127_8069472_6	1229780.BN381_110063	4.311e-61	232.0	COG3000@1|root,COG3000@2|Bacteria,2GMF0@201174|Actinobacteria,3UXB6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_8078642_16	367299.JOEE01000007_gene82	1.777e-34	143.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4FF16@85021|Intrasporangiaceae	201174|Actinobacteria	KT	PspC domain	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
HFD2_k127_8078642_20	1048339.KB913029_gene2814	6.431e-18	99.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4EW85@85013|Frankiales	201174|Actinobacteria	KT	PFAM PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
HFD2_k127_8078642_8	1968.JOEV01000004_gene2829	2.274e-73	255.0	COG4291@1|root,COG4291@2|Bacteria,2GIW8@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
HFD2_k127_8078642_2	1108045.GORHZ_247_00400	5.115e-141	459.0	COG2072@1|root,COG2072@2|Bacteria,2GM3S@201174|Actinobacteria,4GDPG@85026|Gordoniaceae	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
HFD2_k127_8078642_9	35754.JNYJ01000027_gene6174	7.872e-71	247.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria,4DAAX@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_8078642_5	404589.Anae109_4239	1.361e-100	342.0	COG0654@1|root,COG0654@2|Bacteria,1R03K@1224|Proteobacteria,43CQQ@68525|delta/epsilon subdivisions,2X7Y6@28221|Deltaproteobacteria,2Z1K0@29|Myxococcales	28221|Deltaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HFD2_k127_8078642_4	1380386.JIAW01000027_gene7088	4.778e-103	349.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
HFD2_k127_8078642_14	1121381.JNIV01000078_gene2132	1.545e-40	164.0	COG0251@1|root,COG0251@2|Bacteria,1WKNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_8078642_18	1033802.SSPSH_001498	3.88e-24	116.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SC2U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	ycdT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032879,GO:0042710,GO:0044010,GO:0044464,GO:0044764,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0051704,GO:0052621,GO:0065007,GO:0071944,GO:0090605,GO:0090609	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF,MASE4
HFD2_k127_8078642_7	43354.JOIJ01000001_gene104	4.27e-91	316.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria,4DX5Y@85010|Pseudonocardiales	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_8078642_1	1121877.JQKF01000007_gene973	3.019e-156	517.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CMT1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD2_k127_8078642_15	1313172.YM304_42610	2.604e-40	164.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CNBU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD2_k127_8078642_17	1313172.YM304_42620	5.754e-31	132.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CN8W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD2_k127_8078642_10	1313172.YM304_42630	4.049e-55	201.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4CN4R@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD2_k127_8078642_13	1313172.YM304_42640	1.983e-42	159.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4CNDH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD2_k127_8078642_11	1313172.YM304_42670	1.835e-47	173.0	2CQNK@1|root,332VM@2|Bacteria,2HGHQ@201174|Actinobacteria,4CNEW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
HFD2_k127_8078642_12	1313172.YM304_42680	4.05e-43	166.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_8078642_3	345341.KUTG_00976	7.712e-129	449.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DYN9@85010|Pseudonocardiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
HFD2_k127_8078642_0	1229780.BN381_100149	1.039e-177	572.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,3UW9X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HFD2_k127_8078642_6	1313172.YM304_28170	1.912e-98	332.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4CMXH@84992|Acidimicrobiia	84992|Acidimicrobiia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_8078642_22	1121877.JQKF01000017_gene201	5.688e-15	83.0	COG0454@1|root,COG0456@2|Bacteria,2HGG5@201174|Actinobacteria,4CNDG@84992|Acidimicrobiia	84992|Acidimicrobiia	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_8095045_16	1313172.YM304_38500	5.325e-37	145.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
HFD2_k127_8095045_17	1313172.YM304_38490	5.563e-37	147.0	COG0526@1|root,COG0526@2|Bacteria,2HGGP@201174|Actinobacteria,4CNDV@84992|Acidimicrobiia	84992|Acidimicrobiia	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HFD2_k127_8095045_12	1313172.YM304_38480	3.598e-53	207.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
HFD2_k127_8095045_9	1313172.YM304_38590	2.711e-69	248.0	COG4195@1|root,COG4195@2|Bacteria,2GU51@201174|Actinobacteria	201174|Actinobacteria	C	Replication protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
HFD2_k127_8095045_7	1313172.YM304_38620	2.002e-74	267.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
HFD2_k127_8095045_1	1313172.YM304_38630	5.009e-182	578.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CMQR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Seryl-tRNA synthetase N-terminal domain	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD2_k127_8095045_8	1229780.BN381_450049	7.513e-70	263.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,3UX8B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8095045_10	1229780.BN381_450050	3.3e-69	242.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,3UXEV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HFD2_k127_8095045_5	1313172.YM304_38640	2.793e-102	346.0	COG3336@1|root,COG3336@2|Bacteria,2HG9Q@201174|Actinobacteria,4CN83@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
HFD2_k127_8095045_19	1313172.YM304_38650	4.452e-27	113.0	2A8HP@1|root,30XJU@2|Bacteria,2HB16@201174|Actinobacteria	201174|Actinobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD2_k127_8095045_6	1313172.YM304_38660	8.33e-89	301.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4CNAV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
HFD2_k127_8095045_0	1313172.YM304_38670	5e-324	1001.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_8095045_2	1313172.YM304_38680	4.461e-152	491.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4CN92@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
HFD2_k127_8095045_11	1313172.YM304_38690	2.181e-54	205.0	2FBCP@1|root,343IH@2|Bacteria,2H8EE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8095045_13	1313172.YM304_38700	6.119e-53	194.0	COG1845@1|root,COG1845@2|Bacteria,2HDD0@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_8095045_3	1313172.YM304_38710	1.013e-135	451.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
HFD2_k127_8095045_4	1313172.YM304_38720	4.039e-121	399.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4CMQ7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HFD2_k127_8095045_15	1313172.YM304_38150	5.893e-38	153.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4CN8E@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATP-dependent Clp protease adaptor protein ClpS	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD2_k127_8095045_14	1313172.YM304_33950	3.203e-51	185.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_8198735_9	1122138.AQUZ01000008_gene3768	5.121e-39	145.0	2A0U6@1|root,30NYZ@2|Bacteria,2H2K1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YecM
HFD2_k127_8198735_11	985255.APHJ01000039_gene230	4.796e-11	67.0	2CJ4Q@1|root,32S97@2|Bacteria,4NRIP@976|Bacteroidetes,1I2ZM@117743|Flavobacteriia	976|Bacteroidetes	S	Ethyl tert-butyl ether degradation EthD	-	-	-	-	-	-	-	-	-	-	-	-	EthD
HFD2_k127_8198735_5	1123023.JIAI01000002_gene5557	3.182e-89	302.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_8198735_10	1303692.SFUL_1821	8.345e-31	136.0	2DIKZ@1|root,32UB9@2|Bacteria,2IFAU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8198735_14	543632.JOJL01000030_gene3436	2.799e-06	53.0	2F7YJ@1|root,340CE@2|Bacteria,2IIZF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8198735_15	1179773.BN6_66390	7.785e-06	58.0	2F7YJ@1|root,340CE@2|Bacteria,2IIZF@201174|Actinobacteria,4E3M2@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8198735_16	909613.UO65_1806	6.152e-05	53.0	2ER35@1|root,33INS@2|Bacteria,2IR7B@201174|Actinobacteria,4E4B7@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8198735_12	479431.Namu_0432	1.08e-06	58.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HFD2_k127_8198735_1	1229780.BN381_250102	1.753e-197	622.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX7N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_8198735_3	479433.Caci_5206	2.999e-96	345.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_8198735_7	1144275.COCOR_05547	1.916e-60	224.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales	28221|Deltaproteobacteria	EGP	of the major facilitator superfamily	agmP	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HFD2_k127_8198735_8	345341.KUTG_00776	6.058e-59	216.0	COG0583@1|root,COG0583@2|Bacteria,2IE46@201174|Actinobacteria,4E1G7@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_8198735_0	1313172.YM304_34860	7.714e-221	692.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4CMTW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HFD2_k127_8198735_6	1313172.YM304_35090	4.707e-80	295.0	COG0007@1|root,COG0007@2|Bacteria,2GK3B@201174|Actinobacteria,4CMZM@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HFD2_k127_8198735_2	1246995.AFR_39690	1.303e-119	406.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4DAUT@85008|Micromonosporales	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
HFD2_k127_8198735_4	469371.Tbis_3149	9.062e-95	314.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4DXTN@85010|Pseudonocardiales	201174|Actinobacteria	EH	TIGRFAM sulfate adenylyltransferase, small subunit	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD2_k127_8220958_8	1313172.YM304_10420	7.941e-24	101.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD2_k127_8220958_6	1313172.YM304_10460	2.208e-65	235.0	28TNP@1|root,2ZFW6@2|Bacteria,2HAX0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8220958_2	1313172.YM304_10470	6.929e-137	443.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CMPQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_8220958_5	1313172.YM304_10480	2.26e-89	306.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CN5W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Methyltransferase small domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HFD2_k127_8220958_0	471852.Tcur_1129	4.501e-232	737.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria,4EFI8@85012|Streptosporangiales	201174|Actinobacteria	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	pepX	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
HFD2_k127_8220958_4	1297865.APJD01000007_gene2359	8.425e-103	345.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TTZZ@28211|Alphaproteobacteria,3JVH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_17025	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_8220958_3	1313172.YM304_10510	1.08e-118	389.0	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria	201174|Actinobacteria	F	nucleoside hydrolase	rihB	-	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	-	R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HFD2_k127_8220958_1	1313172.YM304_10530	1.527e-176	565.0	COG0183@1|root,COG0183@2|Bacteria,2I3PP@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
HFD2_k127_8223231_28	1120948.KB903218_gene2183	3.876e-08	55.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4E2Y1@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_8223231_0	1313172.YM304_12280	1.376e-295	919.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4CMS4@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HFD2_k127_8223231_25	526225.Gobs_3893	5.206e-16	93.0	COG2197@1|root,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria,4EXDN@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_8223231_26	420324.KI912037_gene2397	2.474e-14	88.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,1QWKB@1224|Proteobacteria,2TX0H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE,Guanylate_cyc,Hydrolase_4
HFD2_k127_8223231_5	525909.Afer_0472	9.565e-148	488.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4CNKK@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_8223231_2	1313172.YM304_10900	7.62e-211	663.0	COG0312@1|root,COG0312@2|Bacteria,2HGNU@201174|Actinobacteria,4CNQT@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_8223231_14	1313172.YM304_10960	1.46e-74	259.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HFD2_k127_8223231_9	1313172.YM304_10970	3.669e-104	345.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD2_k127_8223231_24	1313172.YM304_11000	1.352e-21	98.0	COG2331@1|root,COG2331@2|Bacteria,2HGEB@201174|Actinobacteria,4CP29@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8223231_8	1313172.YM304_11010	3.921e-109	360.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4CMZE@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_8223231_15	1313172.YM304_11020	7.424e-61	229.0	COG3554@1|root,COG3554@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
HFD2_k127_8223231_6	1313172.YM304_11030	1.182e-137	459.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CMP8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD2_k127_8223231_4	1313172.YM304_11040	1.25e-153	494.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4CMV8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HFD2_k127_8223231_7	1313172.YM304_11060	3.442e-135	437.0	2DB7V@1|root,2Z7NX@2|Bacteria,2I9CJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8223231_12	1313172.YM304_11080	4.562e-86	288.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CMYS@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HFD2_k127_8223231_11	994479.GL877882_gene6885	1.933e-87	297.0	COG1028@1|root,COG1028@2|Bacteria,2GJ9X@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_8223231_1	1313172.YM304_13290	1.029e-222	703.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_8223231_22	614083.AWQR01000056_gene3581	4.725e-32	133.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VSZ8@28216|Betaproteobacteria,4ADFB@80864|Comamonadaceae	28216|Betaproteobacteria	M	Beta-Ig-H3 fasciclin	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HFD2_k127_8223231_29	1121887.AUDK01000037_gene808	5.348e-05	53.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,1HWZ3@117743|Flavobacteriia,2NT3U@237|Flavobacterium	976|Bacteroidetes	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HFD2_k127_8223231_19	35754.JNYJ01000036_gene3691	8.978e-34	136.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4DDDF@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_8223231_17	1313172.YM304_02770	9.029e-49	183.0	COG0500@1|root,COG2226@2|Bacteria,2IGKC@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_8223231_21	1121019.AUMN01000001_gene721	1.068e-32	132.0	COG1670@1|root,COG1670@2|Bacteria,2H4AD@201174|Actinobacteria	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8223231_27	68199.JNZO01000013_gene3968	3.758e-12	79.0	COG4922@1|root,COG4922@2|Bacteria,2IA0H@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HFD2_k127_8223231_10	685727.REQ_35050	1.247e-100	346.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4FY3T@85025|Nocardiaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	yogA	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_8223231_3	1150599.MPHLEI_15156	2.534e-172	557.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,232P7@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Activates fatty acids by binding to coenzyme A	fadD36	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K12429,ko:K18662	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_8223231_13	685727.REQ_09990	4.985e-81	292.0	COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,4FXFB@85025|Nocardiaceae	201174|Actinobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_8223231_16	525904.Tter_0396	2.361e-54	210.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_8223231_18	1028801.RG1141_PA01870	4.47e-41	157.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BBPD@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_8260049_9	1313172.YM304_08800	8.183e-06	49.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4CN26@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD2_k127_8260049_1	864702.OsccyDRAFT_1879	9.317e-109	368.0	COG0438@1|root,COG0438@2|Bacteria,1G0TD@1117|Cyanobacteria,1H8K5@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K03867	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_8260049_2	1313172.YM304_08770	4.781e-83	286.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4CNBD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD2_k127_8260049_0	1230476.C207_05478	1.821e-111	376.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,3JS65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD2_k127_8260049_6	269800.Tfu_2745	6.495e-38	149.0	COG1392@1|root,COG1392@2|Bacteria,2GJME@201174|Actinobacteria,4EGZ9@85012|Streptosporangiales	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD2_k127_8260049_4	1313172.YM304_06830	1.69e-57	207.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LMWPc
HFD2_k127_8260049_3	471853.Bcav_2258	6.402e-58	217.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	MA20_27720	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_8260049_7	1274.HX89_00345	1.797e-33	132.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,1ZX0G@145357|Dermacoccaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HFD2_k127_8260049_5	47839.CCAU010000001_gene3026	1.527e-45	168.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria,238NS@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_8285037_3	1218075.BAYA01000006_gene2212	1.066e-22	100.0	COG0583@1|root,COG0583@2|Bacteria,1R818@1224|Proteobacteria,2WEGI@28216|Betaproteobacteria,1KHSY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_8285037_0	1121106.JQKB01000017_gene4848	1.513e-153	494.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2JXBR@204441|Rhodospirillales	204441|Rhodospirillales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_8285037_4	330084.JNYZ01000005_gene1150	2.448e-15	85.0	COG2267@1|root,COG2267@2|Bacteria,2IBJN@201174|Actinobacteria,4EF72@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_8285037_2	298655.KI912266_gene4936	2.171e-27	122.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_8285037_1	1380390.JIAT01000009_gene1443	3.823e-102	349.0	COG0683@1|root,COG0683@2|Bacteria,2GJ2V@201174|Actinobacteria,4CTNJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_8389893_14	1380390.JIAT01000001_gene5018	1.53e-67	237.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CRGQ@84995|Rubrobacteria	84995|Rubrobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8389893_17	710111.FraQA3DRAFT_3068	1.066e-32	139.0	COG1309@1|root,COG1309@2|Bacteria,2IP7V@201174|Actinobacteria,4EX8Z@85013|Frankiales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HFD2_k127_8389893_20	1112204.GPOL_c48660	1.448e-09	60.0	2EK8X@1|root,33DZ6@2|Bacteria,2HXF8@201174|Actinobacteria,4GFIT@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8389893_10	298655.KI912266_gene874	4.015e-87	317.0	COG0577@1|root,COG0577@2|Bacteria,2GN4X@201174|Actinobacteria	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_8389893_12	1123319.AUBE01000016_gene5878	1.409e-71	248.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8389893_15	1108045.GORHZ_159_00350	6.313e-66	239.0	2DKWS@1|root,30N64@2|Bacteria,2IQR3@201174|Actinobacteria,4GEQE@85026|Gordoniaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
HFD2_k127_8389893_2	1123024.AUII01000006_gene4646	2.861e-129	430.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4E1U7@85010|Pseudonocardiales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6,2.5.1.66	ko:K01652,ko:K12673	ko00290,ko00331,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00331,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570,M00674	R00006,R00014,R00226,R03050,R04672,R04673,R05465,R08648	RC00027,RC00106,RC00215,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_8389893_13	113395.AXAI01000002_gene5169	1.369e-67	235.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
HFD2_k127_8389893_6	1123024.AUII01000006_gene4644	2.539e-108	362.0	COG0654@1|root,COG0654@2|Bacteria,2GNA8@201174|Actinobacteria,4E77N@85010|Pseudonocardiales	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.10	ko:K19189	ko00760,ko01120,map00760,map01120	-	R04130	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8
HFD2_k127_8389893_3	1146883.BLASA_1458	3.401e-124	409.0	COG0715@1|root,COG0715@2|Bacteria,2GN9B@201174|Actinobacteria,4EWIV@85013|Frankiales	201174|Actinobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
HFD2_k127_8389893_11	2074.JNYD01000019_gene2605	1.882e-74	258.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_8389893_18	1380356.JNIK01000014_gene3478	2.242e-32	131.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria,4EW4I@85013|Frankiales	201174|Actinobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD2_k127_8389893_1	28444.JODQ01000001_gene2425	9.521e-132	445.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_8389893_9	1380356.JNIK01000014_gene3474	1.845e-89	303.0	COG1136@1|root,COG1136@2|Bacteria,2IDE8@201174|Actinobacteria,4EX5W@85013|Frankiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8389893_19	298655.KI912267_gene7142	2.18e-21	97.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,Response_reg
HFD2_k127_8389893_4	436229.JOEH01000006_gene2937	7.118e-121	397.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
HFD2_k127_8389893_7	1385518.N798_16405	3.692e-102	351.0	COG0664@1|root,COG0664@2|Bacteria,2ID3H@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD2_k127_8389893_8	1380356.JNIK01000014_gene3480	2.131e-90	310.0	COG1235@1|root,COG1235@2|Bacteria,2IJCH@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_8389893_0	649638.Trad_1102	5.286e-163	527.0	COG1233@1|root,COG1233@2|Bacteria,1WM3K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HFD2_k127_8389893_16	102129.Lepto7375DRAFT_8031	5.396e-47	173.0	2ANY6@1|root,31DZ3@2|Bacteria,1G7AH@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF4280)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4280
HFD2_k127_8389893_5	479431.Namu_1911	2.195e-109	389.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2I348@201174|Actinobacteria,4EUJ7@85013|Frankiales	201174|Actinobacteria	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
HFD2_k127_8389920_7	1179773.BN6_12450	2.952e-41	156.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4DXD2@85010|Pseudonocardiales	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_8389920_9	106370.Francci3_3334	1.499e-10	71.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
HFD2_k127_8389920_8	749927.AMED_4319	8.613e-32	130.0	2DWDF@1|root,33ZT1@2|Bacteria,2GU9G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8389920_3	1150864.MILUP08_44806	9.341e-63	223.0	COG0346@1|root,COG0346@2|Bacteria,2HV14@201174|Actinobacteria,4DGGW@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8389920_0	1313172.YM304_15010	8.674e-221	695.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4CMZT@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_8389920_1	1229780.BN381_10099	2.014e-156	502.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,3UX4H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
HFD2_k127_8389920_4	1313172.YM304_29040	3.722e-57	211.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4CNC2@84992|Acidimicrobiia	84992|Acidimicrobiia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_8389920_5	1246474.ANBE01000017_gene4476	1.092e-44	181.0	COG1231@1|root,COG1231@2|Bacteria,2GMV0@201174|Actinobacteria,4EFGX@85012|Streptosporangiales	201174|Actinobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD2_k127_8389920_2	1313172.YM304_14970	8.658e-99	330.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CN9Z@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HFD2_k127_8389920_6	1382306.JNIM01000001_gene1297	2.408e-42	162.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi	200795|Chloroflexi	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HFD2_k127_8506826_2	1996.JOFO01000004_gene3577	3.02e-35	143.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4EIAM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_8506826_6	106370.Francci3_4502	7.482e-16	83.0	COG2905@1|root,COG2905@2|Bacteria,2GVP5@201174|Actinobacteria,4EWMQ@85013|Frankiales	201174|Actinobacteria	T	CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF1918
HFD2_k127_8506826_1	350058.Mvan_1412	3.414e-79	279.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,232QT@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HFD2_k127_8506826_4	56780.SYN_02193	1.211e-26	123.0	COG1503@1|root,COG1503@2|Bacteria,1MXX2@1224|Proteobacteria,42U2M@68525|delta/epsilon subdivisions,2WQS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8506826_5	404589.Anae109_2663	2.834e-18	97.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	chiS	-	2.7.13.3	ko:K07711,ko:K19694	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,GGDEF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
HFD2_k127_8506826_0	744979.R2A130_2496	1.935e-157	507.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD2_k127_8506826_3	1041146.ATZB01000011_gene846	7.505e-31	125.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria,4B80F@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_8567559_29	1313172.YM304_23460	2.131e-09	61.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CN0A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_8567559_14	1313172.YM304_23450	3.651e-92	310.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria	201174|Actinobacteria	KT	Phage shock protein A	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HFD2_k127_8567559_11	1313172.YM304_23440	1.941e-122	402.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4CMY3@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HFD2_k127_8567559_4	1313172.YM304_23430	2.775e-200	637.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4CMVB@84992|Acidimicrobiia	84992|Acidimicrobiia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HFD2_k127_8567559_9	1313172.YM304_23420	1.34e-143	464.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4CMVC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HFD2_k127_8567559_7	1313172.YM304_00800	3.306e-170	544.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_8567559_24	1313172.YM304_18470	6.321e-33	135.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HFD2_k127_8567559_21	1313172.YM304_18460	1.535e-42	157.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4CN9R@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HFD2_k127_8567559_0	1313172.YM304_18440	1.599e-237	749.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4CMPW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribonuclease E/G family	-	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
HFD2_k127_8567559_10	1313172.YM304_18400	5.024e-135	440.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_8567559_1	1313172.YM304_18390	4.387e-220	707.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CMYJ@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_8567559_23	1313172.YM304_18380	6.516e-38	149.0	2EQHK@1|root,33I3K@2|Bacteria,2HGHC@201174|Actinobacteria,4CNEQ@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD2_k127_8567559_28	1111135.HMPREF1248_0709	1.52e-13	82.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria,4CUZG@84998|Coriobacteriia	84998|Coriobacteriia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD2_k127_8567559_5	1313172.YM304_18360	2.486e-199	623.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD2_k127_8567559_18	1313172.YM304_18350	1.996e-67	233.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4CN6F@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HFD2_k127_8567559_6	1313172.YM304_18330	1.447e-180	574.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CNAR@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HFD2_k127_8567559_2	105420.BBPO01000038_gene397	6.424e-206	647.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,2NG8A@228398|Streptacidiphilus	201174|Actinobacteria	O	ClpX C4-type zinc finger	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD2_k127_8567559_13	1313172.YM304_18310	1.86e-106	349.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_8567559_8	1313172.YM304_18300	2.746e-157	509.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4CN55@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
HFD2_k127_8567559_15	35754.JNYJ01000031_gene7037	7.718e-83	292.0	COG0520@1|root,COG0520@2|Bacteria,2GKAF@201174|Actinobacteria,4DANB@85008|Micromonosporales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_8567559_3	1380393.JHVP01000002_gene1923	1.156e-200	656.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HFD2_k127_8567559_17	502025.Hoch_1680	3.116e-74	262.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,4344K@68525|delta/epsilon subdivisions,2X57D@28221|Deltaproteobacteria,2Z07Z@29|Myxococcales	28221|Deltaproteobacteria	P	phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_8567559_30	1121428.DESHY_60023___1	1.154e-07	60.0	COG1708@1|root,COG1708@2|Bacteria,1VM1R@1239|Firmicutes,24UG9@186801|Clostridia	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HFD2_k127_8567559_19	56110.Oscil6304_5139	9.393e-53	194.0	COG4974@1|root,COG4974@2|Bacteria,1G7AU@1117|Cyanobacteria,1HHKG@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
HFD2_k127_8567559_22	196162.Noca_1553	5.902e-42	162.0	COG0671@1|root,COG0671@2|Bacteria,2GNBT@201174|Actinobacteria,4DUJH@85009|Propionibacteriales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K06153,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_8567559_12	298654.FraEuI1c_6741	2.138e-112	376.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EUI2@85013|Frankiales	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_8567559_20	543632.JOJL01000013_gene9434	1.869e-46	181.0	COG0726@1|root,COG0726@2|Bacteria,2GNFA@201174|Actinobacteria,4DIKH@85008|Micromonosporales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD2_k127_8567559_16	318424.EU78_28035	4.606e-82	281.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,238Q9@1762|Mycobacteriaceae	201174|Actinobacteria	P	Zinc permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HFD2_k127_8567559_26	365528.KB891244_gene6413	8.996e-26	110.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_8567559_27	1184609.KILIM_067_00050	2.725e-16	91.0	COG4932@1|root,COG4932@2|Bacteria,2IT7X@201174|Actinobacteria,4F7TP@85018|Dermatophilaceae	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8605906_15	1120948.KB903243_gene2400	3.692e-40	150.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_8605906_11	351607.Acel_0232	5.062e-72	255.0	COG3511@1|root,COG3511@2|Bacteria,2II4P@201174|Actinobacteria,4ET75@85013|Frankiales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
HFD2_k127_8605906_13	935866.JAER01000007_gene447	6.653e-52	191.0	COG4832@1|root,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria,4DQBQ@85009|Propionibacteriales	201174|Actinobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HFD2_k127_8605906_9	1137269.AZWL01000003_gene1487	7e-103	340.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8605906_2	1048339.KB913029_gene2528	8.196e-176	582.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_8605906_16	931627.MycrhDRAFT_0086	1.509e-24	107.0	2CK29@1|root,33KY0@2|Bacteria,2IPTN@201174|Actinobacteria,23AIB@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8605906_3	390989.JOEG01000006_gene802	5.641e-152	487.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4DCGK@85008|Micromonosporales	201174|Actinobacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_8605906_18	471856.Jden_0727	3.878e-16	81.0	COG0640@1|root,COG0640@2|Bacteria,2GQU5@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HFD2_k127_8605906_1	68170.KL590535_gene3741	2.776e-191	607.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4E527@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
HFD2_k127_8605906_14	1906.SFRA_26795	1.463e-42	157.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria	201174|Actinobacteria	P	PFAM DsrC family protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HFD2_k127_8605906_10	1125971.ASJB01000062_gene4443	1.284e-77	263.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EABZ@85010|Pseudonocardiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HFD2_k127_8605906_12	1122239.AULS01000012_gene1118	5.181e-67	239.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4FP0C@85023|Microbacteriaceae	201174|Actinobacteria	EG	EamA-like transporter family	cyeA	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_8605906_7	543728.Vapar_3549	1.832e-123	436.0	COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
HFD2_k127_8605906_17	543728.Vapar_3546	4.324e-24	106.0	2AGAH@1|root,316G1@2|Bacteria,1N2FZ@1224|Proteobacteria,2WDAY@28216|Betaproteobacteria,4AIKB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD2_k127_8605906_0	1283283.ATXA01000024_gene208	5.951e-193	609.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_8605906_5	1192868.CAIU01000033_gene4142	3.071e-143	477.0	COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,2TT1V@28211|Alphaproteobacteria,43J4H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	vanA	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_8605906_4	710687.KI912270_gene3892	7.596e-145	475.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,236IX@1762|Mycobacteriaceae	201174|Actinobacteria	M	Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_8605906_8	1449069.JMLO01000006_gene1186	1.285e-117	415.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FU1D@85025|Nocardiaceae	201174|Actinobacteria	M	ABC transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HFD2_k127_8605906_6	1380347.JNII01000007_gene31	3.004e-139	455.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ESBI@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HFD2_k127_8605906_20	494419.ALPM01000063_gene2240	9.202e-05	51.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,1W9SI@1268|Micrococcaceae	201174|Actinobacteria	OU	NfeD-like C-terminal, partner-binding	nfeD	-	-	-	-	-	-	-	-	-	-	-	NfeD
HFD2_k127_8605906_19	1313172.YM304_02420	5.733e-13	82.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4CMZ4@84992|Acidimicrobiia	84992|Acidimicrobiia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_8621696_3	710696.Intca_0370	3.469e-50	185.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4FFUZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_8621696_1	710696.Intca_0371	5.618e-82	279.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria,4FJTH@85021|Intrasporangiaceae	201174|Actinobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_8621696_2	931627.MycrhDRAFT_4143	3.709e-54	197.0	COG0346@1|root,COG0346@2|Bacteria,2GQZ9@201174|Actinobacteria,239D6@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_8621696_0	1229780.BN381_10316	2.757e-171	554.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,3UWHF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_8621696_4	1312959.KI914676_gene3327	7.365e-39	154.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HFD2_k127_8704843_6	1313172.YM304_37760	1.911e-29	119.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_8704843_3	36809.MAB_4210	1.224e-78	273.0	COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria,232BI@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the NUDIX hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_8704843_5	1313172.YM304_38230	2.156e-51	188.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CN99@84992|Acidimicrobiia	84992|Acidimicrobiia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD2_k127_8704843_1	1313172.YM304_38220	1.49e-141	462.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HFD2_k127_8704843_0	1313172.YM304_38210	3.08e-211	672.0	COG3276@1|root,COG3276@2|Bacteria,2I7V8@201174|Actinobacteria	201174|Actinobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,SelB-wing_3
HFD2_k127_8704843_4	1089544.KB912942_gene1783	4.354e-76	265.0	COG1073@1|root,COG1073@2|Bacteria,2IFI1@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_8704843_2	1313172.YM304_38190	9.1e-129	426.0	COG1030@1|root,COG1030@2|Bacteria,2IATM@201174|Actinobacteria	201174|Actinobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HFD2_k127_907378_8	1313172.YM304_28210	9.48e-06	50.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CN3M@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F420-0:Gamma-glutamyl ligase	fbiB	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HFD2_k127_907378_1	1179773.BN6_80520	3.379e-164	522.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4E09A@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_907378_6	1313172.YM304_28270	6.727e-58	207.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria	201174|Actinobacteria	O	PFAM globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_907378_3	1313172.YM304_28300	1.513e-121	395.0	COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_907378_5	1313172.YM304_28310	2.855e-89	305.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CN4Q@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
HFD2_k127_907378_4	1313172.YM304_28320	1.587e-121	395.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CMPM@84992|Acidimicrobiia	84992|Acidimicrobiia	D	ATPases associated with a variety of cellular activities	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HFD2_k127_907378_2	1313172.YM304_28330	2.785e-162	532.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4CMPD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_907378_0	1313172.YM304_28340	1.045e-286	890.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4CMVS@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD2_k127_916132_8	1313172.YM304_27750	5.872e-25	120.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4352
HFD2_k127_916132_10	1283299.AUKG01000003_gene529	1.029e-08	61.0	COG0583@1|root,COG0583@2|Bacteria,2GMDN@201174|Actinobacteria,4CTQX@84995|Rubrobacteria	84995|Rubrobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_916132_3	1449347.JQLN01000007_gene1838	3.909e-67	246.0	COG1018@1|root,COG1018@2|Bacteria,2HE37@201174|Actinobacteria,2M269@2063|Kitasatospora	201174|Actinobacteria	C	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
HFD2_k127_916132_9	649831.L083_2047	1.589e-18	94.0	COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria,4DG77@85008|Micromonosporales	201174|Actinobacteria	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HFD2_k127_916132_6	465541.ATCJ01000001_gene567	2.111e-50	194.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD2_k127_916132_5	1313172.YM304_13310	7.809e-55	194.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
HFD2_k127_916132_7	525909.Afer_0695	6.653e-35	137.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4CNCN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD2_k127_916132_4	1229780.BN381_450029	1.816e-57	213.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,3UWS5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HFD2_k127_916132_0	1313172.YM304_00590	0.0	1276.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CMVU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HFD2_k127_916132_1	1313172.YM304_13330	2.033e-194	616.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4CMQ4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD2_k127_916132_2	1313172.YM304_13340	5.82e-69	248.0	COG1434@1|root,COG1434@2|Bacteria,2I2NF@201174|Actinobacteria	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HFD2_k127_94212_8	1313172.YM304_18510	3.648e-94	314.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CMTA@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HFD2_k127_94212_19	1313172.YM304_18500	4.181e-29	117.0	COG0227@1|root,COG0227@2|Bacteria,2HH3N@201174|Actinobacteria,4CP3S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD2_k127_94212_20	1313172.YM304_18490	2.71e-25	106.0	COG1278@1|root,COG1278@2|Bacteria,2HC2C@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	-
HFD2_k127_94212_1	1313172.YM304_18480	0.0	1023.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4CMPT@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HFD2_k127_94212_21	1229780.BN381_10335	3.952e-25	113.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_94212_7	1313172.YM304_03860	3.515e-95	319.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
HFD2_k127_94212_15	1333998.M2A_1085	3.43e-48	185.0	COG0406@1|root,COG0406@2|Bacteria,1MYD7@1224|Proteobacteria,2TVST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_94212_6	1313172.YM304_23390	2.431e-105	362.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria	201174|Actinobacteria	S	PFAM LmbE family protein	rifO	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HFD2_k127_94212_3	1313172.YM304_23380	2.148e-184	586.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4CMVD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HFD2_k127_94212_10	309801.trd_0412	5.075e-81	285.0	COG2141@1|root,COG2141@2|Bacteria,2GB6V@200795|Chloroflexi,27XHN@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_94212_14	1229780.BN381_10324	1.733e-56	220.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,3UWRM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HFD2_k127_94212_11	1313172.YM304_23350	3.086e-75	261.0	COG3428@1|root,COG3428@2|Bacteria,2HGDA@201174|Actinobacteria,4CNBH@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
HFD2_k127_94212_4	1313172.YM304_23340	7.701e-129	434.0	COG0210@1|root,COG0349@1|root,COG0210@2|Bacteria,COG0349@2|Bacteria,2GKRW@201174|Actinobacteria,4CNM0@84992|Acidimicrobiia	84992|Acidimicrobiia	L	UvrD-like helicase C-terminal domain	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
HFD2_k127_94212_9	1121927.GOHSU_08_00400	9.265e-86	291.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4GC2H@85026|Gordoniaceae	201174|Actinobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD2_k127_94212_5	1313172.YM304_23320	4.203e-107	363.0	COG0539@1|root,COG0539@2|Bacteria,2I7V9@201174|Actinobacteria	201174|Actinobacteria	J	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	HC2,RNase_Zc3h12a
HFD2_k127_94212_12	1313172.YM304_23310	5.124e-75	275.0	COG1011@1|root,COG1011@2|Bacteria,2IN1K@201174|Actinobacteria	201174|Actinobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD2_k127_94212_22	1122182.KB903813_gene2526	1.685e-10	68.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,4DFR6@85008|Micromonosporales	201174|Actinobacteria	S	Fic/DOC family	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
HFD2_k127_94212_13	1313172.YM304_34960	1.193e-73	263.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HFD2_k127_94212_2	290400.Jann_3814	2.529e-214	687.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD2_k127_94212_16	1298863.AUEP01000005_gene2634	2.707e-44	169.0	2E3HM@1|root,32YG7@2|Bacteria,2IQSQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_94212_17	1120949.KB903316_gene62	1.377e-41	157.0	2DX9S@1|root,3441J@2|Bacteria,2IT0X@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD2_k127_94212_0	1313172.YM304_23290	0.0	1470.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CMWS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HFD2_k127_950217_2	1297865.APJD01000006_gene4753	3.221e-184	581.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,3JRID@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	MA20_04980	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
HFD2_k127_950217_12	500153.JOEK01000001_gene3629	1.824e-70	252.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD2_k127_950217_3	287.DR97_6303	2.193e-174	555.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1YFH7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Dehydrogenase E1 component	bkdA1	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoDH_E1alpha_N
HFD2_k127_950217_1	296591.Bpro_0274	2.29e-184	590.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACZ7@80864|Comamonadaceae	28216|Betaproteobacteria	C	Transketolase, C-terminal domain	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_950217_4	95619.PM1_0222950	2.324e-134	444.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RMJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	bkdB	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_950217_16	1463934.JOCF01000012_gene5400	3.213e-46	175.0	COG1670@1|root,COG1670@2|Bacteria,2I90W@201174|Actinobacteria	201174|Actinobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_950217_11	1313172.YM304_15440	2.24e-71	249.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD2_k127_950217_19	1499967.BAYZ01000104_gene3692	1.999e-40	166.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_950217_13	1313172.YM304_23240	1.594e-62	220.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
HFD2_k127_950217_14	1313172.YM304_23230	6.415e-54	199.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
HFD2_k127_950217_9	1313172.YM304_23220	5.128e-89	307.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HFD2_k127_950217_7	1313172.YM304_23000	7.512e-104	344.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4CMZI@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD2_k127_950217_27	1229780.BN381_330044	1.413e-13	81.0	2E3EP@1|root,31HCP@2|Bacteria,2HM0W@201174|Actinobacteria,3UX08@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_950217_23	1313172.YM304_18780	2.402e-28	119.0	COG0792@1|root,COG0792@2|Bacteria	2|Bacteria	L	nuclease activity	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HFD2_k127_950217_21	1463821.JOGR01000003_gene743	9.518e-33	129.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4EYPV@85014|Glycomycetales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
HFD2_k127_950217_15	1313172.YM304_18770	6.626e-53	188.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CN2N@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HFD2_k127_950217_5	1313172.YM304_18760	2.363e-114	373.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4CMZ9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD2_k127_950217_24	1380370.JIBA01000015_gene367	1.499e-24	117.0	COG3502@1|root,COG3502@2|Bacteria,2I1CH@201174|Actinobacteria,4FHKP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
HFD2_k127_950217_18	644283.Micau_1064	4.201e-42	165.0	2A18G@1|root,30PEU@2|Bacteria,2IGED@201174|Actinobacteria,4DD94@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_950217_17	1313172.YM304_18750	3.624e-43	164.0	COG0806@1|root,COG0806@2|Bacteria,2HGD9@201174|Actinobacteria,4CNBG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	RimM
HFD2_k127_950217_25	1313172.YM304_18740	1.059e-23	106.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	CP_0960	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HFD2_k127_950217_20	1313172.YM304_18730	2.92e-33	130.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CNAD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S16	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD2_k127_950217_0	1313172.YM304_18720	2.384e-222	698.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4CMPN@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HFD2_k127_950217_26	1120959.ATXF01000010_gene157	3.203e-20	107.0	28PF4@1|root,2ZC6F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_950217_6	1229780.BN381_330032	9.017e-110	366.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,3UWGZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HFD2_k127_950217_10	1343740.M271_43680	1.218e-88	314.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_950217_8	1120949.KB903350_gene8124	3.714e-95	320.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4DC77@85008|Micromonosporales	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_954188_12	1379270.AUXF01000001_gene2577	6.66e-19	87.0	COG1960@1|root,COG1960@2|Bacteria,1ZUH3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_954188_5	318424.EU78_25530	1.755e-70	243.0	COG0662@1|root,COG0662@2|Bacteria,2I41N@201174|Actinobacteria,2380V@1762|Mycobacteriaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_954188_13	596151.DesfrDRAFT_1371	5.657e-14	79.0	2F2Z4@1|root,2ZW38@2|Bacteria,1Q0DJ@1224|Proteobacteria,436IR@68525|delta/epsilon subdivisions,2X157@28221|Deltaproteobacteria,2ME98@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_954188_11	1032480.MLP_33830	2.005e-21	96.0	2DREV@1|root,33BF4@2|Bacteria,2ISW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_954188_8	1032480.MLP_33840	4.04e-34	147.0	COG1848@1|root,COG1848@2|Bacteria,2HMSG@201174|Actinobacteria,4DVFP@85009|Propionibacteriales	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_954188_1	1385521.N803_14020	0.0	1204.0	28JBD@1|root,2Z964@2|Bacteria,2H0C3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_954188_2	1385521.N803_14025	0.0	1147.0	2DB7D@1|root,2Z7KR@2|Bacteria,2GKFW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_954188_14	543632.JOJL01000008_gene5951	5.596e-11	66.0	2EEUI@1|root,30871@2|Bacteria,2IS0D@201174|Actinobacteria,4DJBA@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_954188_7	1137268.AZXF01000015_gene807	2.26e-35	143.0	COG1309@1|root,COG1309@2|Bacteria,2IMJ7@201174|Actinobacteria,4EP4T@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_954188_3	298655.KI912266_gene2210	1.023e-187	617.0	COG2909@1|root,COG2909@2|Bacteria,2GM03@201174|Actinobacteria,4ETTY@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HFD2_k127_954188_10	1121946.AUAX01000005_gene5583	4.714e-25	116.0	COG1017@1|root,COG1017@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	fhbA	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Globin,NAD_binding_1
HFD2_k127_954188_9	1040989.AWZU01000037_gene7291	7.071e-34	142.0	COG1017@1|root,COG1017@2|Bacteria,1QVJP@1224|Proteobacteria,2U5M6@28211|Alphaproteobacteria,3JY65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the globin family	-	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	Globin
HFD2_k127_954188_4	1429046.RR21198_4934	6.745e-112	379.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4FWDN@85025|Nocardiaceae	201174|Actinobacteria	P	alkaline phosphatase	phoD	-	3.1.3.1	ko:K01077,ko:K01113	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	PhoD,PhoD_N
HFD2_k127_954188_0	1131814.JAFO01000001_gene3315	0.0	3103.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3EYBF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HFD2_k127_954188_6	219305.MCAG_04760	1.108e-43	162.0	COG1502@1|root,COG1502@2|Bacteria,2GN2V@201174|Actinobacteria,4DANQ@85008|Micromonosporales	201174|Actinobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2
HFD2_k127_96064_17	1030157.AFMP01000026_gene1027	7.149e-30	127.0	COG2141@1|root,COG2141@2|Bacteria,1R7GC@1224|Proteobacteria,2U0DW@28211|Alphaproteobacteria,2K2TE@204457|Sphingomonadales	204457|Sphingomonadales	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_96064_16	1382306.JNIM01000001_gene2242	2.816e-40	167.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_96064_13	365528.KB891263_gene557	2.517e-76	267.0	COG3327@1|root,COG3327@2|Bacteria,2GNME@201174|Actinobacteria,4EU5Y@85013|Frankiales	201174|Actinobacteria	K	PaaX-like protein	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
HFD2_k127_96064_20	408672.NBCG_03247	9.471e-09	64.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4DS17@85009|Propionibacteriales	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB,RHH_1
HFD2_k127_96064_19	1122182.KB903839_gene1105	1.739e-16	89.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4DE6C@85008|Micromonosporales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HFD2_k127_96064_1	1394178.AWOO02000016_gene6866	2.918e-206	658.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG41@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_96064_0	330214.NIDE0352	1.31e-208	678.0	COG0308@1|root,COG0308@2|Bacteria,3J0Y4@40117|Nitrospirae	40117|Nitrospirae	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HFD2_k127_96064_5	1313172.YM304_11110	4.723e-151	484.0	COG0524@1|root,COG0524@2|Bacteria,2HG91@201174|Actinobacteria,4CN70@84992|Acidimicrobiia	84992|Acidimicrobiia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD2_k127_96064_2	1313172.YM304_11120	1.987e-202	649.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_96064_14	1313172.YM304_11150	2.676e-74	256.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HFD2_k127_96064_4	1313172.YM304_11140	1.102e-178	568.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
HFD2_k127_96064_6	1313172.YM304_11130	3.09e-125	414.0	COG5285@1|root,COG5285@2|Bacteria,2I96N@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.18	ko:K00477,ko:K18565	ko00332,ko01130,ko04146,map00332,map01130,map04146	-	R10740,R10741,R10742	RC03267,RC03268,RC03269	ko00000,ko00001,ko01000	-	-	-	PhyH
HFD2_k127_96064_15	1313172.YM304_11170	4.821e-56	198.0	COG0780@1|root,COG0780@2|Bacteria,2GS82@201174|Actinobacteria,4CNEJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD2_k127_96064_10	1242864.D187_009165	8.101e-86	297.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	BQ	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
HFD2_k127_96064_7	58123.JOFJ01000019_gene3833	4.611e-114	389.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4EIFS@85012|Streptosporangiales	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_96064_11	2002.JOEQ01000010_gene6227	1.647e-80	290.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4EGW6@85012|Streptosporangiales	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_96064_3	2002.JOEQ01000010_gene6228	1.102e-188	602.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4EGBM@85012|Streptosporangiales	201174|Actinobacteria	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_96064_9	196162.Noca_3541	2.177e-87	301.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4DPNT@85009|Propionibacteriales	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HFD2_k127_96064_12	1313172.YM304_11230	5.469e-77	268.0	COG2845@1|root,COG2845@2|Bacteria,2GU62@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
HFD2_k127_96064_8	1313172.YM304_11280	4.74e-92	306.0	2C2IJ@1|root,33VBE@2|Bacteria,2H4HS@201174|Actinobacteria,4CN8V@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_96064_18	1313172.YM304_33510	3.875e-26	109.0	COG1024@1|root,COG1024@2|Bacteria,2H2G7@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA14	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_989317_5	55952.BU52_22275	3.353e-73	258.0	COG0329@1|root,COG0329@2|Bacteria,2GNI3@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_989317_9	1381751.JAJB01000010_gene2520	7.022e-58	213.0	COG1802@1|root,COG1802@2|Bacteria,2IBT4@201174|Actinobacteria,4F90W@85019|Brevibacteriaceae	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_989317_1	864051.BurJ1DRAFT_2488	1.223e-107	358.0	COG2084@1|root,COG2084@2|Bacteria,1PGX8@1224|Proteobacteria,2W9GF@28216|Betaproteobacteria,1KNSJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_989317_4	1229780.BN381_80233	5.279e-81	291.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
HFD2_k127_989317_10	1122214.AQWH01000008_gene1568	5.678e-54	204.0	COG1172@1|root,COG1172@2|Bacteria,1MX1K@1224|Proteobacteria,2TUYJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_989317_7	1122214.AQWH01000008_gene1566	5.731e-70	256.0	COG1879@1|root,COG1879@2|Bacteria,1N1FF@1224|Proteobacteria,2UDI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_989317_6	1267535.KB906767_gene8	5.494e-70	263.0	COG0457@1|root,COG0457@2|Bacteria,3Y2M9@57723|Acidobacteria,2JMD8@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD2_k127_989317_0	1122214.AQWH01000008_gene1567	1.778e-130	439.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,2PK99@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BPD_transp_2
HFD2_k127_989317_8	1122214.AQWH01000008_gene1567	5.888e-66	239.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,2PK99@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BPD_transp_2
HFD2_k127_989317_12	298653.Franean1_2722	1.039e-09	66.0	2DXX0@1|root,34713@2|Bacteria,2IN81@201174|Actinobacteria,4EWKC@85013|Frankiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HFD2_k127_989317_2	196490.AUEZ01000006_gene5637	3.074e-95	321.0	COG1335@1|root,COG3386@1|root,COG1335@2|Bacteria,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,3JUN4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GQ	SMP-30/Gluconolaconase/LRE-like region	MA20_13995	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Isochorismatase,SGL
HFD2_k127_989317_3	68570.DC74_5625	1.509e-93	316.0	COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_989317_13	1206729.BAFZ01000001_gene84	0.0001564	51.0	2DYD3@1|root,34976@2|Bacteria,2GRQI@201174|Actinobacteria,4G344@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_989317_11	1313172.YM304_35030	7.755e-45	166.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CNIH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
## 3668 queries scanned
## Total time (seconds): 328.72750306129456
## Rate: 11.16 q/s