## Wed Nov 13 02:54:37 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD2_bin.7.fa -m mmseqs --itype genome -o HFD2_bin.7 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD2_bin.7 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD2_k127_1016663_5	864051.BurJ1DRAFT_4795	6.093e-96	315.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,1KJ01@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	basic membrane	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HFD2_k127_1016663_2	397945.Aave_1136	8.854e-129	419.0	COG4638@1|root,COG4638@2|Bacteria,1MXXI@1224|Proteobacteria,2VKJ1@28216|Betaproteobacteria,4AC1J@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K19982	ko00404,ko01130,map00404,map01130	M00790	R11107	RC01333	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD2_k127_1016663_0	1538295.JY96_02600	6.394e-160	527.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,1KKGG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	-	3.5.4.2	ko:K21053	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HFD2_k127_1016663_1	864051.BurJ1DRAFT_4791	2.753e-146	473.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,1KJS0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HFD2_k127_1016663_6	1265502.KB905956_gene150	6.511e-44	175.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,4AIZH@80864|Comamonadaceae	28216|Betaproteobacteria	T	diguanylate cyclase	pleD	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
HFD2_k127_1016663_3	1392838.AWNM01000031_gene20	2.687e-125	419.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,3T3KV@506|Alcaligenaceae	28216|Betaproteobacteria	E	Extracellular solute-binding protein, family 5 middle family protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_1016663_4	864051.BurJ1DRAFT_4790	9.142e-97	322.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,1KK28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Extradiol ring-cleavage dioxygenase, class III	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_1040061_1	1040982.AXAL01000029_gene4285	2.188e-150	481.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,43KUU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
HFD2_k127_1040061_2	292.DM42_7246	5.742e-83	306.0	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1QTZ6@1224|Proteobacteria,2VNTP@28216|Betaproteobacteria,1K147@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,NB-ARC,Trans_reg_C
HFD2_k127_1040061_6	1348663.KCH_01620	2.014e-20	101.0	COG3450@1|root,COG3450@2|Bacteria,2IHPC@201174|Actinobacteria,2M3BE@2063|Kitasatospora	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
HFD2_k127_1040061_4	1370120.AUWR01000078_gene2703	6.977e-36	153.0	COG1414@1|root,COG1414@2|Bacteria,2I3CC@201174|Actinobacteria,2337H@1762|Mycobacteriaceae	201174|Actinobacteria	K	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD2_k127_1040061_5	234267.Acid_0687	3.524e-29	134.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria	2|Bacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
HFD2_k127_1040061_9	1502850.FG91_03217	0.0008146	52.0	COG3629@1|root,COG5616@1|root,COG3629@2|Bacteria,COG5616@2|Bacteria,1NCCW@1224|Proteobacteria,2UGC8@28211|Alphaproteobacteria,2K3I7@204457|Sphingomonadales	204457|Sphingomonadales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HFD2_k127_1040061_3	861299.J421_1728	3.63e-65	242.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.2,3.6.1.27	ko:K09474,ko:K19302	ko00550,ko00740,ko01100,ko02020,map00550,map00740,map01100,map02020	-	R00548,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_1040061_8	543632.JOJL01000039_gene1562	6.929e-05	55.0	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria,4DIHA@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_1040061_0	864051.BurJ1DRAFT_1185	4.755e-178	561.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1KJ80@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_1040061_7	864051.BurJ1DRAFT_0662	4.242e-13	69.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VHN0@28216|Betaproteobacteria,1KITR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CE	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
HFD2_k127_1043378_2	296591.Bpro_4726	3.384e-100	344.0	COG4243@1|root,COG4243@2|Bacteria,1MW9C@1224|Proteobacteria,2VPG2@28216|Betaproteobacteria,4AIG6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Vitamin k epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1043378_4	864073.HFRIS_006543	1.08e-32	147.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2VUA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HFD2_k127_1043378_3	296591.Bpro_4724	4.056e-54	194.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2VU41@28216|Betaproteobacteria,4AEC9@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	nsrR	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
HFD2_k127_1043378_0	859657.RPSI07_3196	0.0	1291.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,1K467@119060|Burkholderiaceae	28216|Betaproteobacteria	P	nitric oxide reductase	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HFD2_k127_1043378_1	1157708.KB907452_gene3996	1.399e-184	585.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,4AD2V@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
HFD2_k127_1043378_5	1111728.ATYS01000014_gene4805	5.236e-22	103.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	4.2.1.156,4.2.1.42,5.1.2.2	ko:K01781,ko:K20023	ko00053,ko00627,ko01120,map00053,map00627,map01120	-	R03791,R04161,R05608	RC00543,RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_1051286_1	1265502.KB905976_gene518	7.485e-219	687.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,2VI3I@28216|Betaproteobacteria,4A9VU@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM Xanthine uracil vitamin C permease	rutG	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
HFD2_k127_1051286_4	395495.Lcho_4202	1.737e-50	184.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2VRED@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_1051286_0	365046.Rta_05640	3.003e-238	748.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,4A9Q4@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_1051286_2	420662.Mpe_A3369	1.289e-105	347.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,1KJR5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Reversible hydration of carbon dioxide	can	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Pro_CA
HFD2_k127_1051286_3	1265502.KB905932_gene1925	9.549e-89	296.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,4ABTR@80864|Comamonadaceae	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HFD2_k127_1076110_2	420662.Mpe_A3646	7.577e-137	439.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,2VP74@28216|Betaproteobacteria,1KJ6C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HFD2_k127_1076110_6	269482.Bcep1808_2032	5.044e-11	71.0	2AFDS@1|root,315DM@2|Bacteria,1PVFU@1224|Proteobacteria,2WDKN@28216|Betaproteobacteria,1KAJ3@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1076110_0	395495.Lcho_0510	1.869e-153	491.0	COG0697@1|root,COG0697@2|Bacteria,1MW7P@1224|Proteobacteria,2VHDI@28216|Betaproteobacteria,1KKBB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	ytfF	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1076110_5	420662.Mpe_A1012	1.964e-82	284.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,2VIHJ@28216|Betaproteobacteria,1KNRG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
HFD2_k127_1076110_1	1463936.JOJI01000061_gene7230	1.04e-146	485.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria	201174|Actinobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_1076110_3	296591.Bpro_3929	3.08e-105	351.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,4AC1Z@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methyltransferase type 11	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_1076110_4	536019.Mesop_1222	3.818e-89	301.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD2_k127_1078856_13	234267.Acid_4911	1.429e-12	68.0	2EX9M@1|root,33QKC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1078856_3	864051.BurJ1DRAFT_2704	5.207e-149	482.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VN0D@28216|Betaproteobacteria,1KKFJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_1078856_10	114615.BRADO2379	2.075e-51	184.0	COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2UET5@28211|Alphaproteobacteria,3JYU1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA
HFD2_k127_1078856_5	288000.BBta_2732	1.468e-110	367.0	COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2TVHU@28211|Alphaproteobacteria,3JTGW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	MA20_10350	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1078856_6	1245469.S58_52480	5.064e-97	325.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2UAU0@28211|Alphaproteobacteria,3K6NH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	pobR	-	-	ko:K18954	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,Cupin_2,HTH_18
HFD2_k127_1078856_2	864051.BurJ1DRAFT_2708	7.707e-221	689.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2VPD5@28216|Betaproteobacteria,1KKCT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HFD2_k127_1078856_11	338969.Rfer_0299	2.366e-42	159.0	COG0633@1|root,COG0633@2|Bacteria,1PTDB@1224|Proteobacteria,2VTTT@28216|Betaproteobacteria,4AJK6@80864|Comamonadaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HFD2_k127_1078856_9	1123257.AUFV01000010_gene3322	1.924e-55	203.0	2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,1S8YX@1236|Gammaproteobacteria,1X7EG@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HFD2_k127_1078856_4	864051.BurJ1DRAFT_4931	9.298e-112	373.0	COG2199@1|root,COG3706@2|Bacteria,1NC00@1224|Proteobacteria,2VQIK@28216|Betaproteobacteria,1KKST@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
HFD2_k127_1078856_0	983917.RGE_29280	0.0	1089.0	COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,2WGQ6@28216|Betaproteobacteria,1KKAI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_1078856_1	338966.Ppro_0419	6.221e-298	933.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,43U1C@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HFD2_k127_1078856_7	296591.Bpro_2641	3.346e-93	322.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,4AACE@80864|Comamonadaceae	28216|Betaproteobacteria	O	protein-L-isoaspartate O-methyltransferase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_1078856_8	296591.Bpro_4739	8.991e-58	218.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,4AHXY@80864|Comamonadaceae	28216|Betaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_1078856_12	296591.Bpro_1634	3.542e-41	154.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HFD2_k127_1095947_5	395495.Lcho_0761	7.644e-18	83.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,1KK0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_1095947_1	864051.BurJ1DRAFT_1701	1.173e-172	548.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,1KJ88@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_1095947_2	864051.BurJ1DRAFT_1700	2.417e-162	517.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1KJNJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_1095947_0	1265502.KB905964_gene1382	6.453e-211	665.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,4A9RX@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM AAA ATPase central domain protein	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HFD2_k127_1095947_3	420662.Mpe_A1121	1.02e-61	215.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,1KKPS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HFD2_k127_1147788_8	864051.BurJ1DRAFT_0835	4.909e-38	144.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2VTTR@28216|Betaproteobacteria,1KIVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Tryptophan halogenase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_1147788_2	420662.Mpe_A3628	5.012e-125	404.0	COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,2VJP1@28216|Betaproteobacteria,1KKGS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Glutamine amido-transferase	yafJ	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HFD2_k127_1147788_7	29581.BW37_04805	4.078e-50	198.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,475K1@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD2_k127_1147788_1	983917.RGE_45890	2.914e-292	920.0	COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria	1224|Proteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_1147788_3	983917.RGE_40030	1.147e-122	402.0	COG3203@1|root,COG3203@2|Bacteria,1R8YD@1224|Proteobacteria,2VNCH@28216|Betaproteobacteria,1KPA0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_1147788_6	1265502.KB905937_gene2600	3.26e-65	232.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VRRI@28216|Betaproteobacteria,4ADXG@80864|Comamonadaceae	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_1147788_0	420662.Mpe_A3626	1.615e-305	961.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KJ3Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	iorB2	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_1147788_4	983917.RGE_19120	8.664e-103	359.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,W_rich_C
HFD2_k127_1147788_5	983917.RGE_45880	2.988e-84	284.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KNF8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
HFD2_k127_1175051_1	452637.Oter_1752	1.669e-259	811.0	COG1501@1|root,COG1501@2|Bacteria,46TKY@74201|Verrucomicrobia,3K9R3@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF5110,Glyco_hydro_31
HFD2_k127_1175051_0	1198452.Jab_2c25550	0.0	1186.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2WAKQ@28216|Betaproteobacteria,477CY@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Domain of unknown function (DUF4982)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD2_k127_1175051_2	1207055.C100_19590	3.848e-200	658.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U0KF@28211|Alphaproteobacteria,2K2GK@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Malectin
HFD2_k127_1175051_3	380358.XALC_1934	2.864e-58	220.0	COG3291@1|root,COG3291@2|Bacteria,1QWZ9@1224|Proteobacteria,1T30T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cellulase N-terminal ig-like domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
HFD2_k127_1203438_6	331869.BAL199_17623	9.966e-55	201.0	COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria,4BQUK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HFD2_k127_1203438_7	864051.BurJ1DRAFT_3415	1.487e-50	192.0	2ANVS@1|root,31DWA@2|Bacteria,1RKIA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1203438_3	1173027.Mic7113_3342	4.12e-92	317.0	COG0457@1|root,COG0457@2|Bacteria,1G42F@1117|Cyanobacteria,1HEPF@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1203438_2	864051.BurJ1DRAFT_3410	4.311e-103	367.0	COG1073@1|root,COG1073@2|Bacteria,1RJ7T@1224|Proteobacteria	1224|Proteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_1203438_5	864051.BurJ1DRAFT_3411	1.187e-57	225.0	COG0586@1|root,COG0586@2|Bacteria,1N958@1224|Proteobacteria	1224|Proteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_1203438_1	864051.BurJ1DRAFT_3412	2.82e-176	574.0	COG0189@1|root,COG0189@2|Bacteria,1R4B7@1224|Proteobacteria	1224|Proteobacteria	HJ	D-alanine--D-alanine ligase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp
HFD2_k127_1203438_0	420662.Mpe_A0032	6.772e-189	602.0	2DBEC@1|root,2Z8RY@2|Bacteria,1MXRI@1224|Proteobacteria,2VP4Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3943)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3943
HFD2_k127_1203438_4	381666.H16_A1822	8.382e-84	291.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3,PAS_4
HFD2_k127_1264938_2	864051.BurJ1DRAFT_3891	4.103e-150	479.0	COG1175@1|root,COG1175@2|Bacteria,1P9M5@1224|Proteobacteria,2VKR9@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HFD2_k127_1264938_0	864051.BurJ1DRAFT_3892	5.597e-263	815.0	COG1653@1|root,COG1653@2|Bacteria,1R0XV@1224|Proteobacteria,2VNJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HFD2_k127_1264938_3	296591.Bpro_3531	2.552e-138	447.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VIVP@28216|Betaproteobacteria,4AA44@80864|Comamonadaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_1264938_1	864051.BurJ1DRAFT_4720	5.351e-186	588.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1KJB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HFD2_k127_1265629_1	983917.RGE_14770	5.155e-180	586.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg
HFD2_k127_1265629_2	420662.Mpe_A1762	1.624e-112	368.0	COG3503@1|root,COG3503@2|Bacteria,1RA1Q@1224|Proteobacteria,2VNUA@28216|Betaproteobacteria,1KKFQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HFD2_k127_1265629_0	864051.BurJ1DRAFT_1697	1.019e-185	589.0	COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2VHU2@28216|Betaproteobacteria,1KJT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_1265629_3	983917.RGE_32950	4.387e-100	330.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria,1KN0J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
HFD2_k127_1265629_4	1265502.KB905940_gene2951	1.339e-65	229.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,4AAVB@80864|Comamonadaceae	28216|Betaproteobacteria	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_1316787_5	1123504.JQKD01000002_gene4029	1.246e-23	101.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,4AJ8R@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1316787_0	1380394.JADL01000009_gene3150	0.0	1031.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HFD2_k127_1316787_1	864051.BurJ1DRAFT_4518	3.123e-214	691.0	COG3227@1|root,COG3227@2|Bacteria,1QXPY@1224|Proteobacteria	1224|Proteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	ko:K01417	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,FTP,PA,Peptidase_M36
HFD2_k127_1316787_3	365044.Pnap_1116	5.931e-95	317.0	COG4221@1|root,COG4221@2|Bacteria,1QXBX@1224|Proteobacteria,2WH93@28216|Betaproteobacteria,4AEPB@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD2_k127_1316787_4	398578.Daci_5387	6.408e-54	196.0	COG0494@1|root,COG0494@2|Bacteria,1R8RB@1224|Proteobacteria,2WH5A@28216|Betaproteobacteria,4AAIU@80864|Comamonadaceae	28216|Betaproteobacteria	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4743,NUDIX
HFD2_k127_1316787_2	983917.RGE_24120	1.605e-123	399.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1KKET@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD2_k127_1319860_6	748247.AZKH_2369	3.583e-07	51.0	COG4654@1|root,COG4654@2|Bacteria,1N457@1224|Proteobacteria,2VVMH@28216|Betaproteobacteria,2KX9J@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD2_k127_1319860_0	983917.RGE_01000	1.735e-210	660.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,1KJWX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD2_k127_1319860_5	887062.HGR_03487	1.118e-41	158.0	COG3556@1|root,COG3556@2|Bacteria,1N3XH@1224|Proteobacteria,2VRQ4@28216|Betaproteobacteria,4AE2D@80864|Comamonadaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2214)	-	-	-	ko:K08983	-	-	-	-	ko00000	-	-	-	DUF2214
HFD2_k127_1319860_4	1458275.AZ34_16265	1.202e-74	257.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2VWNC@28216|Betaproteobacteria,4AFPM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HFD2_k127_1319860_2	864051.BurJ1DRAFT_2810	2.113e-115	388.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,1KITW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	ubiF	-	-	ko:K03184	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R06146,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HFD2_k127_1319860_3	864051.BurJ1DRAFT_0115	8.889e-78	267.0	COG1266@1|root,COG1266@2|Bacteria,1RJZQ@1224|Proteobacteria,2VSUQ@28216|Betaproteobacteria,1KNGN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD2_k127_1319860_1	420662.Mpe_A3732	1.146e-159	509.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,1KK6V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Major facilitator superfamily	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
HFD2_k127_1325355_4	420662.Mpe_A2949	8.097e-49	198.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,1KKV8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD2_k127_1325355_3	1265502.KB905943_gene2726	1.072e-72	247.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,4AE39@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD2_k127_1325355_0	420662.Mpe_A2947	3.785e-183	586.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1KJYX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD2_k127_1325355_2	420662.Mpe_A2946	2.444e-88	321.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,1KKYI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HFD2_k127_1325355_1	365046.Rta_15230	3.243e-151	485.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,4ABFU@80864|Comamonadaceae	28216|Betaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD2_k127_1325355_5	1286631.X805_19850	6.51e-37	149.0	COG4967@1|root,COG4967@2|Bacteria,1RKWI@1224|Proteobacteria,2VT6F@28216|Betaproteobacteria,1KM55@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	type IV pilus modification protein PilV	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD2_k127_1332623_1	864051.BurJ1DRAFT_2059	1.155e-207	649.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,1KJKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
HFD2_k127_1332623_0	983917.RGE_35650	1.143e-256	808.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,1KISV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	GAF domain	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
HFD2_k127_1332623_2	864051.BurJ1DRAFT_3721	6.478e-152	487.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1KJA7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	aldA	-	-	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	-	R00711	RC00047	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD2_k127_1337098_5	864051.BurJ1DRAFT_3342	6.22e-47	172.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
HFD2_k127_1337098_0	1485544.JQKP01000005_gene306	1.15e-110	365.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria,44W7U@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HFD2_k127_1337098_3	864051.BurJ1DRAFT_3340	3.369e-57	209.0	28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,2VUGA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1337098_4	864051.BurJ1DRAFT_3339	8.691e-56	196.0	COG2920@1|root,COG2920@2|Bacteria,1N2HP@1224|Proteobacteria,2VVGF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HFD2_k127_1337098_2	864051.BurJ1DRAFT_3338	1.347e-61	218.0	2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,2VVIY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cas6 Crispr	-	-	-	-	-	-	-	-	-	-	-	-	Cas6
HFD2_k127_1337098_6	864051.BurJ1DRAFT_3337	1.357e-18	87.0	2EMP6@1|root,33FBM@2|Bacteria,1NGBE@1224|Proteobacteria,2VYCB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1337098_1	864051.BurJ1DRAFT_3336	4.031e-73	249.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2VPWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HFD2_k127_1402730_4	420662.Mpe_A1955	5.655e-103	343.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,1KJR8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_1402730_0	267608.RSp0228	3.236e-232	736.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2WH2X@28216|Betaproteobacteria,1KIHC@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Activator of aromatic catabolism	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat,V4R,XylR_N
HFD2_k127_1402730_1	296591.Bpro_0128	1.492e-209	672.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VH71@28216|Betaproteobacteria,4AGVQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	xylC	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_1402730_2	296591.Bpro_0129	3.097e-126	408.0	COG1028@1|root,COG1028@2|Bacteria,1R6NY@1224|Proteobacteria,2VPVH@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	3-alpha-hydroxysteroid dehydrogenase carbonyl reductase oxidoreductase protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_1402730_3	381666.H16_A0577	7.158e-126	426.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,1K3M6@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_1402730_5	296591.Bpro_0130	1.862e-77	267.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VHHF@28216|Betaproteobacteria,4AES6@80864|Comamonadaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
HFD2_k127_1411004_4	663610.JQKO01000016_gene1595	5.334e-35	135.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2U7V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HFD2_k127_1411004_1	93220.LV28_09595	1.407e-99	338.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Methyltransferase	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HFD2_k127_1411004_2	390989.JOEG01000017_gene6236	3.538e-64	228.0	COG0428@1|root,COG0428@2|Bacteria,2GSYE@201174|Actinobacteria,4DDCM@85008|Micromonosporales	201174|Actinobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HFD2_k127_1411004_3	1122604.JONR01000004_gene814	9.748e-63	235.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,1S3X0@1236|Gammaproteobacteria,1X6FP@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD2_k127_1411004_0	1123073.KB899241_gene2320	5.829e-127	414.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,1RSNG@1236|Gammaproteobacteria,1X6B5@135614|Xanthomonadales	135614|Xanthomonadales	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD2_k127_1437578_2	395495.Lcho_1561	4.963e-117	392.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,1KJGF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD2_k127_1437578_0	420662.Mpe_A1256	3.52e-233	727.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,1KJT2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HFD2_k127_1437578_3	595537.Varpa_4877	1.153e-102	338.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,4ACXF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Inhibitor of apoptosis-promoting Bax1	yccA	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HFD2_k127_1437578_5	420662.Mpe_A1258	5.184e-59	208.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,1KKW1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Haem-degrading	glcG	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HFD2_k127_1437578_1	987059.RBXJA2T_09652	1.451e-201	634.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,1KIZC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD2_k127_1437578_4	983917.RGE_33290	1.591e-99	325.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD2_k127_1439642_2	420662.Mpe_A2845	6.138e-142	452.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,1KJSQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD2_k127_1439642_1	987059.RBXJA2T_12397	4.628e-164	532.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1KIY3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD2_k127_1439642_5	1265502.KB905931_gene1667	2.082e-42	158.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VU5B@28216|Betaproteobacteria,4AEZ1@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HFD2_k127_1439642_0	864051.BurJ1DRAFT_3705	5.593e-254	791.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,1KIVQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD2_k127_1439642_6	420662.Mpe_A2848	1.169e-33	131.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,1KMJY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HFD2_k127_1439642_3	1265502.KB905931_gene1664	3.349e-72	270.0	COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,2VRT2@28216|Betaproteobacteria,4AHNG@80864|Comamonadaceae	28216|Betaproteobacteria	H	Nicotinamide mononucleotide transporter	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
HFD2_k127_1439642_4	1538295.JY96_01700	2.601e-62	222.0	COG3172@1|root,COG3172@2|Bacteria,1RI98@1224|Proteobacteria,2VSFE@28216|Betaproteobacteria,1KM5K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
HFD2_k127_1474625_1	614083.AWQR01000028_gene3133	7.646e-113	364.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria,4AAFX@80864|Comamonadaceae	28216|Betaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_1474625_2	1003200.AXXA_09693	7.274e-76	261.0	COG1309@1|root,COG1309@2|Bacteria,1R7QZ@1224|Proteobacteria,2VNS3@28216|Betaproteobacteria,3T71U@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_1474625_3	365046.Rta_00950	9.754e-61	221.0	COG1073@1|root,COG1073@2|Bacteria,1MZUA@1224|Proteobacteria,2VNP3@28216|Betaproteobacteria,4ACVX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4
HFD2_k127_1474625_0	1121937.AUHJ01000002_gene3454	1.53e-158	524.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	O-linked N-acetylglucosamine transferase SPINDLY family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_7,TPR_8
HFD2_k127_1485900_5	1265502.KB905931_gene1615	3.092e-46	168.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4AB5M@80864|Comamonadaceae	28216|Betaproteobacteria	T	TIGRFAM nitrogen regulation protein NR(I)	ntrC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_1485900_1	1265502.KB905931_gene1614	6.656e-178	575.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,4AA8Q@80864|Comamonadaceae	28216|Betaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HFD2_k127_1485900_6	420662.Mpe_A2075	4.319e-44	180.0	2BWQ4@1|root,32QZV@2|Bacteria,1MZQ9@1224|Proteobacteria,2VSNR@28216|Betaproteobacteria,1KM87@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HFD2_k127_1485900_0	1265502.KB905931_gene1612	8.263e-304	936.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,4AAV7@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD2_k127_1485900_2	296591.Bpro_1806	4.461e-120	407.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,4AA7R@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM molybdopterin binding domain	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD2_k127_1485900_3	358220.C380_08485	2.076e-100	335.0	COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria,2VN29@28216|Betaproteobacteria,4AB0N@80864|Comamonadaceae	28216|Betaproteobacteria	E	Etoposide-induced protein 2.4 (EI24)	-	-	-	-	-	-	-	-	-	-	-	-	EI24
HFD2_k127_1485900_4	1538295.JY96_14235	8.43e-71	240.0	COG3391@1|root,COG3391@2|Bacteria,1R78P@1224|Proteobacteria,2VJ7I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1503133_0	338969.Rfer_3920	3.993e-259	814.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_1503133_2	864051.BurJ1DRAFT_4956	1.188e-186	621.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,1KJS3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_1503133_5	614083.AWQR01000045_gene2050	2.912e-74	279.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria,4AACB@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_1503133_1	420662.Mpe_A0077	6.502e-213	673.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2WGRW@28216|Betaproteobacteria,1KK18@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	two-component sensor kinase	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_1503133_4	987059.RBXJA2T_13539	2.137e-125	410.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,1KK1U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	basR_3	-	-	ko:K02483,ko:K07666,ko:K07774	ko02020,ko02024,map02020,map02024	M00453,M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_1503133_3	864051.BurJ1DRAFT_4952	2.357e-136	436.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1KIVV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD2_k127_1509197_18	1463917.JODC01000001_gene508	5.59e-40	159.0	COG2015@1|root,COG2015@2|Bacteria	2|Bacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1509197_13	1095769.CAHF01000022_gene156	1.619e-75	270.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VQ0S@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HFD2_k127_1509197_6	543728.Vapar_5758	2.005e-150	481.0	COG0605@1|root,COG0607@1|root,COG0605@2|Bacteria,COG0607@2|Bacteria,1R4Z3@1224|Proteobacteria,2VN2K@28216|Betaproteobacteria,4ADCX@80864|Comamonadaceae	28216|Betaproteobacteria	P	Superoxide dismutase	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Rhodanese,Sod_Fe_C
HFD2_k127_1509197_10	391038.Bphy_5138	1.598e-86	296.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,1K3UW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Chromate resistance	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HFD2_k127_1509197_5	1158292.JPOE01000002_gene2591	4.912e-158	524.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria,1KJHJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	DMT(Drug metabolite transporter) superfamily permease	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1509197_21	596154.Alide2_4665	1.556e-19	93.0	2EAM8@1|root,334PW@2|Bacteria,1NCDI@1224|Proteobacteria,2VXI3@28216|Betaproteobacteria,4AFSR@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1509197_20	358220.C380_09525	6.496e-21	104.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,4AFIW@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rubA1	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HFD2_k127_1509197_12	358220.C380_09530	2.54e-80	280.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,4AEPM@80864|Comamonadaceae	28216|Betaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD2_k127_1509197_15	864051.BurJ1DRAFT_3552	6.416e-58	221.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,1KM3I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
HFD2_k127_1509197_16	864051.BurJ1DRAFT_3553	3.96e-51	186.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,2VU18@28216|Betaproteobacteria,1KMG6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Domain of unknown function (DUF1924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1924
HFD2_k127_1509197_19	1123255.JHYS01000020_gene2728	2.465e-24	107.0	COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2VWE0@28216|Betaproteobacteria,4AFJM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HFD2_k127_1509197_9	864051.BurJ1DRAFT_3555	8.585e-119	391.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1KJQ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_1509197_2	864051.BurJ1DRAFT_3556	2.243e-175	562.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2VIZI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	phoQ	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
HFD2_k127_1509197_22	290400.Jann_1495	2.926e-16	93.0	2DNMU@1|root,32Y5V@2|Bacteria,1NDWM@1224|Proteobacteria,2UNH9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1509197_8	395495.Lcho_1136	2.136e-125	413.0	COG3005@1|root,COG3005@2|Bacteria,1QZ6I@1224|Proteobacteria,2VPS8@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HFD2_k127_1509197_11	395495.Lcho_1137	2.436e-82	300.0	296YQ@1|root,2ZU7A@2|Bacteria,1RDAE@1224|Proteobacteria,2VS5K@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1509197_1	395495.Lcho_1138	2.479e-183	582.0	COG1018@1|root,COG1018@2|Bacteria,1MV41@1224|Proteobacteria,2VIIV@28216|Betaproteobacteria,1KK8D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	hmp	-	1.14.12.17	ko:K05916,ko:K07006,ko:K21832	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,Globin,NAD_binding_1
HFD2_k127_1509197_17	365046.Rta_11660	1.739e-42	159.0	2EC1S@1|root,3360X@2|Bacteria,1N9VV@1224|Proteobacteria,2VX12@28216|Betaproteobacteria,4AFGI@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1509197_4	2074.JNYD01000010_gene979	5.287e-160	515.0	COG3135@1|root,COG3135@2|Bacteria,2GNQX@201174|Actinobacteria,4DYUB@85010|Pseudonocardiales	201174|Actinobacteria	Q	Benzoate membrane transport protein	benE	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
HFD2_k127_1509197_0	338969.Rfer_2197	0.0	1576.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,4AAEC@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC
HFD2_k127_1509197_3	1163407.UU7_09330	2.586e-166	569.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg,dCache_1
HFD2_k127_1509197_7	196367.JNFG01000030_gene8584	3.392e-131	429.0	COG1879@1|root,COG1879@2|Bacteria,1R8HF@1224|Proteobacteria,2VM7A@28216|Betaproteobacteria,1K4G4@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
HFD2_k127_1509197_14	1458357.BG58_40785	5.906e-64	226.0	COG1279@1|root,COG1279@2|Bacteria,1QXRU@1224|Proteobacteria,2WH6P@28216|Betaproteobacteria,1KIRU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HFD2_k127_1523796_3	395495.Lcho_4299	7.268e-133	424.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,1KJG1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_1523796_1	1286631.X805_24520	3.31e-278	875.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VI73@28216|Betaproteobacteria,1KJVV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CH	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HFD2_k127_1523796_13	1286631.X805_24530	1.649e-23	117.0	2E3JP@1|root,32YI0@2|Bacteria,1N6ZI@1224|Proteobacteria,2VWGY@28216|Betaproteobacteria,1KMSM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2783
HFD2_k127_1523796_5	365044.Pnap_1119	2.309e-109	354.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2VNZN@28216|Betaproteobacteria,4ABGD@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_1523796_2	322710.Avin_50190	2.901e-194	625.0	COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,1RQYW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN746.PP_4620	FAA_hydrolase,FAA_hydrolase_N
HFD2_k127_1523796_0	1265502.KB905938_gene2459	0.0	1244.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,4AA5S@80864|Comamonadaceae	28216|Betaproteobacteria	C	Phosphate acetyl butaryl transferase	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HFD2_k127_1523796_6	1280944.HY17_17275	1.993e-85	306.0	COG2133@1|root,COG3474@1|root,COG2133@2|Bacteria,COG3474@2|Bacteria,1MV2E@1224|Proteobacteria,2UAVE@28211|Alphaproteobacteria,43ZK2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,GSDH
HFD2_k127_1523796_9	667632.KB890165_gene2262	4.26e-68	253.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Globin,HTH_3,HTH_31
HFD2_k127_1523796_7	667632.KB890165_gene2261	3.332e-82	292.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_1523796_4	667632.KB890165_gene2260	2.237e-120	408.0	COG0809@1|root,COG0809@2|Bacteria	2|Bacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD2_k127_1523796_14	1304275.C41B8_03032	1.537e-14	78.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	dksA traR	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD2_k127_1523796_10	166318.Syn8016DRAFT_2839	1.228e-63	223.0	COG0229@1|root,COG0229@2|Bacteria,1G60F@1117|Cyanobacteria,1GZZ9@1129|Synechococcus	1117|Cyanobacteria	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_1523796_8	1395571.TMS3_0111245	7.4e-72	251.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,1T62V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA2	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD2_k127_1523796_12	1005048.CFU_0214	3.591e-35	151.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,2WIH6@28216|Betaproteobacteria,4796W@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
HFD2_k127_1523796_11	861299.J421_1730	1.312e-40	165.0	COG1595@1|root,COG1595@2|Bacteria,1ZUWF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD2_k127_1530288_1	420662.Mpe_A2324	6.095e-188	589.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,1KJGK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_1530288_9	864051.BurJ1DRAFT_2861	8.698e-54	201.0	COG2199@1|root,COG2199@2|Bacteria,1RGJM@1224|Proteobacteria,2VRG5@28216|Betaproteobacteria,1KKYZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_1530288_11	550540.Fbal_2074	3.161e-07	62.0	2AKF7@1|root,31B6Q@2|Bacteria,1N34J@1224|Proteobacteria,1SHID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1530288_3	864051.BurJ1DRAFT_2863	1.849e-141	452.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1KIVR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD2_k127_1530288_4	864051.BurJ1DRAFT_2862	1.766e-133	444.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,1KN58@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	dacB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S13
HFD2_k127_1530288_5	420662.Mpe_A2850	2.015e-117	381.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,1KJ2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HFD2_k127_1530288_8	864051.BurJ1DRAFT_2865	3.258e-86	292.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,1KKUU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_11,TetR_N
HFD2_k127_1530288_6	420662.Mpe_A1044	6.019e-111	380.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,2VJVW@28216|Betaproteobacteria,1KJY9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	nolF	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1530288_0	420662.Mpe_A1043	0.0	1714.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD2_k127_1530288_7	1265502.KB905929_gene2292	1.202e-95	317.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,4AAHT@80864|Comamonadaceae	28216|Betaproteobacteria	O	Methyltransferase type 11	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_1530288_10	864051.BurJ1DRAFT_2869	2.074e-29	133.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,2VU52@28216|Betaproteobacteria,1KM8W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rhodanese-like domain	pspE2	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_1530288_2	420662.Mpe_A1041	1.302e-163	527.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,1KK6Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	TIGRFAM type I secretion outer membrane protein, TolC family	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HFD2_k127_1531224_3	1265502.KB905941_gene2877	3.045e-61	215.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2VJ3C@28216|Betaproteobacteria,4AB9J@80864|Comamonadaceae	28216|Betaproteobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HFD2_k127_1531224_2	395495.Lcho_3826	2.673e-78	268.0	COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,1KKP1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	signal sequence binding	sco1	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1531224_1	420662.Mpe_A3176	5.892e-82	284.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,1KKUG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SURF1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
HFD2_k127_1531224_0	420662.Mpe_A3177	7.258e-159	505.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,1KJDY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c oxidase subunit	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD2_k127_1531224_4	1538295.JY96_05390	1.002e-24	107.0	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,1KMJR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
HFD2_k127_1538558_0	420662.Mpe_A3633	1.679e-173	555.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,1KK2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Fumarylacetoacetate (Faa) hydrolase	mhpD2	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_1538558_2	864051.BurJ1DRAFT_0278	1.525e-51	197.0	2DN7F@1|root,32VYA@2|Bacteria,1QUZI@1224|Proteobacteria,2VUAZ@28216|Betaproteobacteria,1KMCG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HFD2_k127_1538558_3	420662.Mpe_A3630	2.805e-30	122.0	2E6W9@1|root,32SGN@2|Bacteria,1MZMD@1224|Proteobacteria,2VU0A@28216|Betaproteobacteria,1KMHJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3567)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3567
HFD2_k127_1538558_1	420662.Mpe_A0165	1.001e-143	459.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2VK2M@28216|Betaproteobacteria,1KKCB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD2_k127_1544394_1	1265502.KB905931_gene1615	1.697e-152	486.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4AB5M@80864|Comamonadaceae	28216|Betaproteobacteria	T	TIGRFAM nitrogen regulation protein NR(I)	ntrC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_1544394_15	1194165.CAJF01000038_gene3421	3.987e-51	202.0	29YCS@1|root,30K75@2|Bacteria,2IJFN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1544394_3	420662.Mpe_A0977	8.831e-129	434.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VJMJ@28216|Betaproteobacteria,1KJZY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ABC-2 type transporter	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_1544394_2	420662.Mpe_A0978	4.231e-148	501.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VM20@28216|Betaproteobacteria,1KJ9S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	hndI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_1544394_4	322710.Avin_03430	2.582e-128	433.0	28HWK@1|root,2Z82H@2|Bacteria,1MVDT@1224|Proteobacteria,1RQ61@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipoprotein	yaiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009279,GO:0010033,GO:0010243,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031240,GO:0031975,GO:0042221,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:1901652,GO:1901698,GO:1901700	-	-	-	-	-	-	-	-	-	-	DUF1615
HFD2_k127_1544394_14	1123504.JQKD01000016_gene1905	7.007e-53	193.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VVH4@28216|Betaproteobacteria,4AEZV@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_1544394_13	1538295.JY96_06855	2.238e-54	195.0	2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1544394_18	296591.Bpro_0926	1.563e-18	89.0	COG4876@1|root,COG4876@2|Bacteria,1NJCS@1224|Proteobacteria,2VYBB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1544394_19	1349767.GJA_3765	9.082e-11	74.0	COG0671@1|root,COG0671@2|Bacteria,1QV0A@1224|Proteobacteria,2WGP2@28216|Betaproteobacteria,474QC@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_1544394_16	983917.RGE_27730	1.36e-38	146.0	COG1983@1|root,COG1983@2|Bacteria,1N62S@1224|Proteobacteria,2VU5Z@28216|Betaproteobacteria,1KMFS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC,SHOCT
HFD2_k127_1544394_5	1472716.KBK24_0116850	3.227e-125	408.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VIAS@28216|Betaproteobacteria,1JZYA@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HFD2_k127_1544394_7	640512.BC1003_2845	1.958e-87	293.0	COG1335@1|root,COG1335@2|Bacteria,1RBHB@1224|Proteobacteria,2VNM8@28216|Betaproteobacteria,1K0F6@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD2_k127_1544394_12	1395571.TMS3_0106625	3.67e-55	216.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,1SYEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1544394_6	1395571.TMS3_0106625	5.361e-97	327.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,1SYEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1544394_9	1031711.RSPO_c00135	1.521e-71	251.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VI89@28216|Betaproteobacteria,1K84U@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2,GST_N_3
HFD2_k127_1544394_10	266834.SMc00383	4.712e-69	241.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2TS1B@28211|Alphaproteobacteria,4BAM4@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstch1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD2_k127_1544394_0	365044.Pnap_3586	1.538e-196	637.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2VHVQ@28216|Betaproteobacteria,4ACAE@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Peptidoglycan-binding domain 1 protein	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD2_k127_1544394_11	365044.Pnap_3585	1.131e-60	237.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,4AE1P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HFD2_k127_1544394_8	864051.BurJ1DRAFT_1451	1.375e-73	252.0	28HPC@1|root,2Z7XD@2|Bacteria,1REIX@1224|Proteobacteria,2VS60@28216|Betaproteobacteria,1KMBS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HFD2_k127_1544394_17	1265502.KB905931_gene1623	2.696e-32	128.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,4ADWV@80864|Comamonadaceae	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HFD2_k127_1560558_4	420662.Mpe_A0709	9.406e-106	347.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,1KJM4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Amidohydrolase family	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD2_k127_1560558_2	1265502.KB905941_gene2899	9.621e-185	586.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,4ABIN@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_1560558_6	1265502.KB905941_gene2900	4.465e-76	269.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,2VSNM@28216|Betaproteobacteria,4ADHM@80864|Comamonadaceae	28216|Betaproteobacteria	F	phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD2_k127_1560558_7	987059.RBXJA2T_00185	4.854e-52	199.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,1KM0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD2_k127_1560558_5	1265502.KB905941_gene2902	1.552e-96	318.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,4AAUH@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HFD2_k127_1560558_0	420662.Mpe_A0704	2.074e-235	736.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,1KIUG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	DNA photolyase	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HFD2_k127_1560558_3	1265502.KB905941_gene2904	6.778e-123	403.0	COG2199@1|root,COG3706@2|Bacteria,1R6GI@1224|Proteobacteria,2VM5N@28216|Betaproteobacteria,4A9XC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_1560558_1	1265502.KB905941_gene2905	3.013e-217	681.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ABCW@80864|Comamonadaceae	28216|Betaproteobacteria	T	ATP-binding region, ATPase domain protein	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HFD2_k127_1574352_3	864051.BurJ1DRAFT_2070	4.308e-50	188.0	2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,2VRRJ@28216|Betaproteobacteria,1KKVZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1574352_1	864051.BurJ1DRAFT_2068	2.892e-196	626.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,1KJ6I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD2_k127_1574352_2	395495.Lcho_3015	1.991e-186	589.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,1KMB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_1574352_0	1538295.JY96_11055	1.536e-275	883.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2W1GY@28216|Betaproteobacteria,1KPE8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_8,Response_reg
HFD2_k127_1626873_6	987059.RBXJA2T_16237	4.067e-31	123.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,1KMC6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0250 family	ybeD	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HFD2_k127_1626873_4	1265502.KB905959_gene282	1.793e-96	321.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,4ABST@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HFD2_k127_1626873_1	395495.Lcho_0401	1.741e-187	589.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,1KJ50@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HFD2_k127_1626873_2	420662.Mpe_A1033	8.616e-120	392.0	29AFQ@1|root,2ZXFW@2|Bacteria,1RGFB@1224|Proteobacteria,2VQD0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HFD2_k127_1626873_5	987059.RBXJA2T_16222	1.054e-94	317.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,1KKF4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
HFD2_k127_1626873_3	1265502.KB905938_gene2514	1.241e-119	396.0	COG0784@1|root,COG0784@2|Bacteria,1R078@1224|Proteobacteria,2VN9R@28216|Betaproteobacteria,4AIUG@80864|Comamonadaceae	28216|Betaproteobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1626873_0	983917.RGE_44040	2.497e-193	617.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1KJ0W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD2_k127_1626873_7	1265502.KB905938_gene2513	5.607e-17	91.0	2EBNJ@1|root,335NT@2|Bacteria,1N847@1224|Proteobacteria,2VW9H@28216|Betaproteobacteria,4AFB6@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1630976_1	1218076.BAYB01000007_gene1271	2.088e-191	602.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KDJU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinase, N-terminal domain protein	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_1630976_5	190486.XAC4243	3.529e-69	257.0	COG0235@1|root,COG0235@2|Bacteria,1REUS@1224|Proteobacteria	1224|Proteobacteria	G	Aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD2_k127_1630976_0	316273.XCV4348	8.936e-262	824.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1X3C9@135614|Xanthomonadales	135614|Xanthomonadales	H	Glutamate-1-semialdehyde aminotransferase	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_1630976_6	983917.RGE_11190	2.171e-58	209.0	COG0235@1|root,COG0235@2|Bacteria,1RK14@1224|Proteobacteria	1224|Proteobacteria	G	Class ii aldolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1630976_2	983917.RGE_11280	1.722e-104	352.0	COG0477@1|root,COG2814@2|Bacteria,1QKNX@1224|Proteobacteria,2W5QA@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_1630976_3	1198452.Jab_2c30080	2.559e-89	301.0	COG3393@1|root,COG3393@2|Bacteria,1RAAU@1224|Proteobacteria,2WFRU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
HFD2_k127_1630976_4	266117.Rxyl_2457	7.873e-80	276.0	COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_1630976_7	366602.Caul_2973	2.221e-36	146.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_1676487_4	887062.HGR_15679	1.228e-67	241.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VMS6@28216|Betaproteobacteria,4AGMW@80864|Comamonadaceae	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_1676487_3	365046.Rta_17650	2.273e-76	265.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2VJQ7@28216|Betaproteobacteria,4AA1M@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.175	ko:K22185	ko00040,map00040	-	R01429	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD2_k127_1676487_2	983917.RGE_16710	4.209e-107	352.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,1KK7D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
HFD2_k127_1676487_6	420662.Mpe_A0576	3.854e-38	145.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,1KMB2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HFD2_k127_1676487_1	987059.RBXJA2T_00610	4.89e-115	375.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2VIU6@28216|Betaproteobacteria,1KJIU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
HFD2_k127_1676487_7	983917.RGE_16740	1.441e-28	117.0	COG3190@1|root,COG3190@2|Bacteria,1NHJX@1224|Proteobacteria,2W9KI@28216|Betaproteobacteria,1KMGP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar biosynthesis protein, FliO	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
HFD2_k127_1676487_5	420662.Mpe_A0573	1.748e-60	211.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,2VSZ7@28216|Betaproteobacteria,1KKUP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar motor switch protein fliN	fliN	-	-	ko:K02417,ko:K03225	ko02030,ko02040,ko03070,map02030,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	FliMN_C
HFD2_k127_1676487_0	420662.Mpe_A0572	4.2e-134	429.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2VI0A@28216|Betaproteobacteria,1KK5A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar motor switch	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
HFD2_k127_1691091_1	420662.Mpe_A0265	9.517e-171	539.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1KJ17@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
HFD2_k127_1691091_3	420662.Mpe_A2229	4.196e-125	413.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,1KN7P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_1691091_4	1538295.JY96_05340	4.293e-57	202.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,2VQFF@28216|Betaproteobacteria,1KKUR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
HFD2_k127_1691091_2	864051.BurJ1DRAFT_0880	5.631e-128	413.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,1KK20@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HFD2_k127_1691091_0	983917.RGE_44640	1.094e-173	555.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,1KJDF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD2_k127_1691091_5	420662.Mpe_A0273	1.69e-53	195.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,1KM6N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HFD2_k127_1734998_1	748280.NH8B_2256	9.659e-100	354.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,2KQ7Q@206351|Neisseriales	206351|Neisseriales	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_1734998_0	1294143.H681_02090	1.054e-138	453.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HFD2_k127_1734998_4	1265502.KB905929_gene2224	6.532e-20	94.0	2E7T6@1|root,3328B@2|Bacteria,1N8UT@1224|Proteobacteria,2VVWC@28216|Betaproteobacteria,4AG0G@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1734998_2	1265502.KB905952_gene791	3.117e-53	208.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,4AADJ@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139,ko:K18903	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00698,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,1.B.17.3.3,2.A.6.2	-	-	OEP
HFD2_k127_1734998_3	1454004.AW11_00391	2.254e-48	198.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1744013_0	1366050.N234_26220	5.177e-91	325.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2VM8X@28216|Betaproteobacteria,1K2Z9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_1744013_3	1123251.ATWM01000002_gene197	7.022e-50	193.0	COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4FFDR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
HFD2_k127_1744013_1	1205680.CAKO01000026_gene4539	1.198e-61	235.0	COG1396@1|root,COG1396@2|Bacteria,1Q1NG@1224|Proteobacteria,2TVY4@28211|Alphaproteobacteria,2JZIE@204441|Rhodospirillales	204441|Rhodospirillales	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HFD2_k127_1744013_2	859657.RPSI07_3162	2.469e-57	213.0	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2VQXS@28216|Betaproteobacteria,1K1II@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	ttr	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD2_k127_1754623_5	1123377.AUIV01000012_gene700	1.624e-21	106.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	CP_0257	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HFD2_k127_1754623_3	614083.AWQR01000031_gene2686	1.14e-38	147.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2VVJM@28216|Betaproteobacteria,4AEUN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HFD2_k127_1754623_0	1005048.CFU_0081	1.478e-63	220.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,47785@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_1754623_1	748247.AZKH_4441	4.679e-58	204.0	COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,2VSIB@28216|Betaproteobacteria,2KYQ7@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD2_k127_1754623_2	614083.AWQR01000056_gene3579	9.791e-39	151.0	COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2VS8Y@28216|Betaproteobacteria,4AJM5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HFD2_k127_1754623_4	864051.BurJ1DRAFT_1894	1.82e-35	147.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HFD2_k127_1754623_7	358220.C380_11870	6.731e-15	79.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,2W4W2@28216|Betaproteobacteria,4AIAW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HFD2_k127_1754623_6	1038859.AXAU01000020_gene5454	2.336e-21	97.0	2BSBG@1|root,32MD9@2|Bacteria,1R813@1224|Proteobacteria,2U3H4@28211|Alphaproteobacteria,3JWD4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1762484_9	1500897.JQNA01000002_gene4232	1.12e-66	237.0	COG0583@1|root,COG0583@2|Bacteria,1R49T@1224|Proteobacteria,2VK85@28216|Betaproteobacteria,1K4XP@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1762484_13	953739.SVEN_0697	1.835e-24	110.0	COG2329@1|root,COG2329@2|Bacteria,2H53P@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4865
HFD2_k127_1762484_12	404589.Anae109_3113	1.691e-33	133.0	COG1942@1|root,COG1942@2|Bacteria,1RHA5@1224|Proteobacteria,431G6@68525|delta/epsilon subdivisions,2WWH2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
HFD2_k127_1762484_7	211114.JOEF01000001_gene7602	4.505e-91	323.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4DYP8@85010|Pseudonocardiales	201174|Actinobacteria	S	Short-chain alcohol dehydrogenase	-	-	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100	-	R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000	-	-	-	adh_short
HFD2_k127_1762484_10	1150626.PHAMO_270139	8.245e-65	230.0	COG3703@1|root,COG3703@2|Bacteria,1RDNV@1224|Proteobacteria	1224|Proteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	VV2631	-	-	-	-	-	-	-	-	-	-	-	ChaC,GGACT
HFD2_k127_1762484_6	864051.BurJ1DRAFT_3409	7.609e-100	332.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2VH4B@28216|Betaproteobacteria,1KJIG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
HFD2_k127_1762484_2	543728.Vapar_0356	4.875e-135	449.0	COG3181@1|root,COG3181@2|Bacteria,1R5K3@1224|Proteobacteria,2VHGB@28216|Betaproteobacteria,4AD5F@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_1762484_4	864051.BurJ1DRAFT_2763	2.466e-114	374.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,1KKGU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	nagK	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_1762484_1	395495.Lcho_3670	3.059e-176	560.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,1KK11@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Cupin domain	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD2_k127_1762484_3	543728.Vapar_0352	2.18e-123	402.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,4ADKQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1762484_8	667632.KB890198_gene1132	2.746e-75	263.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2VW59@28216|Betaproteobacteria,1KHAS@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N
HFD2_k127_1762484_5	748247.AZKH_p0041	5.155e-105	361.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_1762484_11	395961.Cyan7425_1172	1.675e-60	228.0	COG1733@1|root,COG1733@2|Bacteria,1GBX0@1117|Cyanobacteria	1117|Cyanobacteria	K	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
HFD2_k127_1762484_0	399795.CtesDRAFT_PD2426	1.706e-261	811.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HFD2_k127_1769337_2	1286631.X805_06830	8.085e-95	324.0	COG1470@1|root,COG1858@1|root,COG3291@1|root,COG3391@1|root,COG5563@1|root,COG1470@2|Bacteria,COG1858@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5563@2|Bacteria,1QZSZ@1224|Proteobacteria	1224|Proteobacteria	C	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CCP_MauG,Cytochrom_C,DUF1929,F5_F8_type_C,He_PIG,LVIVD,Laminin_G_3,PKD,Ricin_B_lectin
HFD2_k127_1769337_5	1306990.BARG01000131_gene10375	2.545e-21	107.0	COG3325@1|root,COG3408@1|root,COG3325@2|Bacteria,COG3408@2|Bacteria,2IEEI@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HFD2_k127_1769337_0	420662.Mpe_A3140	1.437e-175	554.0	COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,1KJEZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA
HFD2_k127_1769337_3	1123256.KB907931_gene2865	3.346e-41	159.0	COG1017@1|root,COG1017@2|Bacteria,1QUQ4@1224|Proteobacteria,1SAA1@1236|Gammaproteobacteria,1X8I3@135614|Xanthomonadales	135614|Xanthomonadales	C	Globin	-	-	-	-	-	-	-	-	-	-	-	-	Globin
HFD2_k127_1769337_1	743836.AYNA01000045_gene1234	5.824e-108	386.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U17W@28211|Alphaproteobacteria,37188@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_7,Response_reg
HFD2_k127_1769337_4	1149133.ppKF707_1564	1.285e-33	131.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RXE9@1236|Gammaproteobacteria,1YJ0W@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_1806251_3	420662.Mpe_A1416	3.408e-91	302.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,1KJ1X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_1806251_2	1265502.KB905936_gene2651	6.312e-113	369.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,4AAI5@80864|Comamonadaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD2_k127_1806251_5	420662.Mpe_A1418	5.541e-81	276.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,1KKQA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HFD2_k127_1806251_7	1265502.KB905936_gene2648	8.429e-52	192.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2VSCN@28216|Betaproteobacteria,4AECI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HFD2_k127_1806251_0	420662.Mpe_A1420	4.579e-213	685.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,1KJIS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_1806251_8	420662.Mpe_A1421	1.049e-35	139.0	COG3308@1|root,COG3308@2|Bacteria,1N1EF@1224|Proteobacteria,2VU3C@28216|Betaproteobacteria,1KMGX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
HFD2_k127_1806251_1	420662.Mpe_A1422	6.362e-184	591.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,1KJDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD2_k127_1806251_4	75379.Tint_0808	2.053e-84	296.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,1NWNJ@1224|Proteobacteria,2W2SI@28216|Betaproteobacteria,1KPEV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4
HFD2_k127_1806251_6	864051.BurJ1DRAFT_0841	1.033e-54	194.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,1KKJS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,FSH1
HFD2_k127_181414_7	1458357.BG58_40785	4.748e-27	119.0	COG1279@1|root,COG1279@2|Bacteria,1QXRU@1224|Proteobacteria,2WH6P@28216|Betaproteobacteria,1KIRU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HFD2_k127_181414_5	987059.RBXJA2T_02612	5.517e-55	197.0	COG1522@1|root,COG1522@2|Bacteria,1RI47@1224|Proteobacteria,2VT2Z@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_181414_2	1538295.JY96_12380	2.939e-120	389.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1KJU5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD2_k127_181414_6	395495.Lcho_3900	2e-52	187.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KM27@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HFD2_k127_181414_1	983917.RGE_02870	6.735e-163	523.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,1KJY2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	MltA specific insert domain	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HFD2_k127_181414_4	987059.RBXJA2T_15358	6.04e-76	291.0	COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,2VS5N@28216|Betaproteobacteria,1KNKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21019	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
HFD2_k127_181414_3	420662.Mpe_A3501	3.471e-78	266.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2VQ7U@28216|Betaproteobacteria,1KKR2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
HFD2_k127_181414_0	358220.C380_23050	0.0	1480.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,4AC8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_1826228_3	864051.BurJ1DRAFT_3042	5.781e-101	330.0	COG1795@1|root,COG1795@2|Bacteria,1MWYS@1224|Proteobacteria,2VNIQ@28216|Betaproteobacteria,1KK21@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Formaldehyde-activating enzyme (Fae)	-	-	-	-	-	-	-	-	-	-	-	-	Fae
HFD2_k127_1826228_0	420662.Mpe_A2628	2.315e-252	792.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VHXV@28216|Betaproteobacteria,1KJ4R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
HFD2_k127_1826228_6	543728.Vapar_3061	1.632e-84	290.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae	28216|Betaproteobacteria	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD2_k127_1826228_2	983917.RGE_40460	1.86e-126	419.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KN1P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406,ko:K03776,ko:K05875	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,sCache_2
HFD2_k127_1826228_7	983917.RGE_40470	2.333e-61	218.0	COG0501@1|root,COG0501@2|Bacteria,1N2BV@1224|Proteobacteria,2VVDE@28216|Betaproteobacteria,1KMF6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_1826228_5	420662.Mpe_A3043	4.291e-89	325.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VQ32@28216|Betaproteobacteria,1KK16@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	gacA	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_1826228_1	864051.BurJ1DRAFT_3735	9.765e-185	602.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VNHG@28216|Betaproteobacteria,1KK0T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HATPase_c_2,HisKA_3,LapD_MoxY_N,PAS,PAS_9
HFD2_k127_1826228_4	543728.Vapar_3058	6.372e-97	326.0	COG2021@1|root,COG2021@2|Bacteria,1R0TW@1224|Proteobacteria,2WHWB@28216|Betaproteobacteria,4AK33@80864|Comamonadaceae	28216|Betaproteobacteria	E	Alpha/beta hydrolase family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HFD2_k127_1826855_2	1276756.AUEX01000021_gene3303	7.55e-127	414.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,4ACPS@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1826855_6	1121935.AQXX01000093_gene3401	3.99e-71	245.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,1XJX6@135619|Oceanospirillales	135619|Oceanospirillales	S	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
HFD2_k127_1826855_3	987059.RBXJA2T_12032	1.865e-79	276.0	COG0572@1|root,COG0572@2|Bacteria,1QV2B@1224|Proteobacteria,2VQ8H@28216|Betaproteobacteria,1KKT7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	COG1072 Panthothenate kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,PRK
HFD2_k127_1826855_1	339670.Bamb_4162	2.717e-177	573.0	COG0531@1|root,COG0531@2|Bacteria,1R4PP@1224|Proteobacteria,2VMV2@28216|Betaproteobacteria,1KCZ8@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD2_k127_1826855_0	1207075.PputUW4_01856	1.051e-203	655.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	nfdA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_1826855_5	1206777.B195_21645	9.695e-73	256.0	COG2197@1|root,COG2197@2|Bacteria,1NPE8@1224|Proteobacteria,1TBT6@1236|Gammaproteobacteria,1ZAGR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_1826855_7	420662.Mpe_A1558	5.027e-34	139.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	MA20_05910	-	-	ko:K03668,ko:K09914	-	-	-	-	ko00000	-	-	-	META
HFD2_k127_1826855_4	296591.Bpro_2738	1.855e-73	256.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2WC2E@28216|Betaproteobacteria,4AIRV@80864|Comamonadaceae	28216|Betaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HFD2_k127_1827290_5	420662.Mpe_A3066	2.154e-19	88.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2VJAZ@28216|Betaproteobacteria,1KIXV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
HFD2_k127_1827290_4	420662.Mpe_A3065	1.068e-97	330.0	COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,2VH35@28216|Betaproteobacteria,1KK43@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MNOU	TIGRFAM flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Rod-binding
HFD2_k127_1827290_0	420662.Mpe_A3064	6.449e-219	698.0	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,1KJU1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD2_k127_1827290_3	420662.Mpe_A3063	2.325e-124	409.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,2VM4I@28216|Betaproteobacteria,1KK2H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HFD2_k127_1827290_2	420662.Mpe_A3062	3.143e-164	545.0	COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,2VKZY@28216|Betaproteobacteria,1KJJQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	signal transduction protein containing EAL and modified HD-GYP domains	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
HFD2_k127_1827290_1	983917.RGE_17380	9.619e-171	561.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2VNX9@28216|Betaproteobacteria,1KKC6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_2,PAS_4,PAS_8,PAS_9
HFD2_k127_1843686_8	1265502.KB905931_gene1608	7.059e-39	150.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,4AJZ3@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg
HFD2_k127_1843686_0	864051.BurJ1DRAFT_0325	8.594e-259	807.0	COG2270@1|root,COG2270@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08162,ko:K08226,ko:K16211	-	-	-	-	ko00000,ko02000	2.A.1.2.21,2.A.1.41,2.A.2.6	-	-	MFS_1,PUCC
HFD2_k127_1843686_3	864051.BurJ1DRAFT_2387	2.294e-128	415.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2VK7I@28216|Betaproteobacteria,1KNH7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD2_k127_1843686_2	864051.BurJ1DRAFT_0760	5.571e-136	444.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VH5E@28216|Betaproteobacteria,1KJF6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.132,4.2.1.80	ko:K02509,ko:K18364	ko00350,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00350,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02601,R04132,R05864,R06897	RC00750,RC01615,RC02595,RC02676	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_1843686_7	1100720.ALKN01000033_gene755	8.449e-58	204.0	COG3232@1|root,COG3232@2|Bacteria,1RB8A@1224|Proteobacteria,2VRSE@28216|Betaproteobacteria,4AE9A@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM 5-carboxymethyl-2-hydroxymuconate isomerase	hpaF	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	CHMI
HFD2_k127_1843686_4	257310.BB0735	9.864e-116	389.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VMPC@28216|Betaproteobacteria,3T274@506|Alcaligenaceae	28216|Betaproteobacteria	Q	4-hydroxyphenylacetate degradation bifunctional isomerase decarboxylase	-	-	4.1.1.68	ko:K05921	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04134,R04380	RC01085,RC02669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_1843686_6	292.DM42_3721	8.819e-64	225.0	COG0179@1|root,COG0179@2|Bacteria,1R51B@1224|Proteobacteria,2VSKH@28216|Betaproteobacteria,1K4I7@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	4-hydroxyphenylacetate degradation bifunctional isomerase decarboxylase	hpaG	-	4.1.1.68	ko:K05921	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04134,R04380	RC01085,RC02669	ko00000,ko00001,ko00002,ko01000	-	-	-	CHMI,FAA_hydrolase
HFD2_k127_1843686_1	420662.Mpe_A0871	3.995e-141	456.0	COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,2VHGD@28216|Betaproteobacteria,1KNCM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_1843686_5	296591.Bpro_3430	9.443e-86	294.0	COG0657@1|root,COG0657@2|Bacteria,1MW4D@1224|Proteobacteria,2VIHB@28216|Betaproteobacteria,4A9R0@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HFD2_k127_1843686_9	543728.Vapar_2562	8.217e-08	66.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VHW3@28216|Betaproteobacteria,4AA9A@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	bepF	-	-	ko:K18901	-	M00698	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_1853950_4	1123368.AUIS01000027_gene1331	1.702e-75	269.0	COG3206@1|root,COG3206@2|Bacteria,1QUY4@1224|Proteobacteria	1224|Proteobacteria	M	PFAM lipopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HFD2_k127_1853950_0	365046.Rta_05340	5.807e-136	452.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJ15@28216|Betaproteobacteria,4ACTX@80864|Comamonadaceae	28216|Betaproteobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_1853950_5	365046.Rta_05360	2.173e-53	214.0	COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2VQA3@28216|Betaproteobacteria,4ADJ6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD2_k127_1853950_2	1265502.KB905966_gene1221	3.532e-109	359.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2VHM0@28216|Betaproteobacteria,4ABI5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phenazine biosynthesis protein phzf family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HFD2_k127_1853950_1	1265502.KB905966_gene1221	4.665e-116	385.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2VHM0@28216|Betaproteobacteria,4ABI5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phenazine biosynthesis protein phzf family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HFD2_k127_1853950_3	1265502.KB905966_gene1222	8.421e-104	340.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VHE6@28216|Betaproteobacteria,4A9JE@80864|Comamonadaceae	28216|Betaproteobacteria	EK	PFAM aminotransferase, class I and II	lysN	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HFD2_k127_1853951_1	927677.ALVU02000001_gene4596	6.913e-98	351.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1GAED@1117|Cyanobacteria	1117|Cyanobacteria	C	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_1853951_3	1265502.KB905966_gene1219	4.9e-71	258.0	COG0454@1|root,COG0456@2|Bacteria,1PNX8@1224|Proteobacteria,2VR63@28216|Betaproteobacteria,4ADZB@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_1853951_2	864051.BurJ1DRAFT_0306	4.395e-94	316.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,1KKNF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD2_k127_1853951_4	395495.Lcho_3537	6.515e-50	186.0	COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,2VSGD@28216|Betaproteobacteria,1KM1U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD2_k127_1853951_0	395495.Lcho_0648	2.44e-213	692.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VJBU@28216|Betaproteobacteria,1KJHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Polysaccharide biosynthesis/export protein	kpsD	-	-	-	-	-	-	-	-	-	-	-	Caps_synth_GfcC,Poly_export,SLBB
HFD2_k127_1870964_3	1265502.KB905939_gene2407	1.539e-112	369.0	COG1960@1|root,COG1960@2|Bacteria,1QMQC@1224|Proteobacteria,2VK52@28216|Betaproteobacteria,4AB8K@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_1870964_4	1286093.C266_14362	6.305e-93	312.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJNG@28216|Betaproteobacteria,1K20Y@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_1870964_0	1286631.X805_11580	1.384e-266	851.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,1KKAU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HFD2_k127_1870964_2	1286631.X805_11570	2.748e-143	462.0	COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VJ1Y@28216|Betaproteobacteria,1KKBR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_1870964_1	864051.BurJ1DRAFT_3924	6.135e-201	630.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,1KK5R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_1870964_5	1100720.ALKN01000049_gene514	1.236e-29	119.0	COG0824@1|root,COG0824@2|Bacteria,1RG6B@1224|Proteobacteria,2VTAU@28216|Betaproteobacteria,4ADWM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase-like superfamily	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_1897635_8	1123504.JQKD01000003_gene531	9.515e-53	189.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,4ABST@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HFD2_k127_1897635_9	987059.RBXJA2T_16237	2.449e-40	151.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,1KMC6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0250 family	ybeD	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HFD2_k127_1897635_2	1265502.KB905959_gene279	6.806e-151	482.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,4ACXI@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Amino-transferase class IV	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_1897635_1	987059.RBXJA2T_16247	1.633e-167	535.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,1KJ7B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HFD2_k127_1897635_5	420662.Mpe_A0310	1.385e-82	278.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,1KKMK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Thioesterase
HFD2_k127_1897635_7	1157708.KB907464_gene490	1.122e-54	194.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,4AEGC@80864|Comamonadaceae	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HFD2_k127_1897635_3	1265502.KB905959_gene275	9.499e-127	415.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,4ABFG@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM VanZ family protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HFD2_k127_1897635_6	420662.Mpe_A0307	1.592e-67	234.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,1KKV6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
HFD2_k127_1897635_0	1286631.X805_35880	6.151e-181	571.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,1KJ96@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HFD2_k127_1897635_4	365046.Rta_01980	4.843e-111	368.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VIII@28216|Betaproteobacteria,4ABDN@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_1897635_10	987059.RBXJA2T_16287	2.679e-29	117.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2VSHV@28216|Betaproteobacteria,1KKVR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HFD2_k127_1907241_0	1265502.KB905939_gene2391	7.115e-223	694.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,4ACPE@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_1907241_1	1265502.KB905939_gene2390	8.309e-148	483.0	COG1737@1|root,COG1737@2|Bacteria,1MV3U@1224|Proteobacteria,2VH1T@28216|Betaproteobacteria,4AB7K@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix protein RpiR	hexR	-	-	ko:K19337	-	-	-	-	ko00000,ko03000	-	-	-	HTH_6,SIS
HFD2_k127_1907241_4	338969.Rfer_1872	7.625e-36	150.0	COG2197@1|root,COG2197@2|Bacteria,1NDQC@1224|Proteobacteria,2VRW4@28216|Betaproteobacteria,4AE7N@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_1907241_3	1122604.JONR01000033_gene8	1.87e-41	174.0	COG4319@1|root,COG4319@2|Bacteria,1N361@1224|Proteobacteria,1S9P8@1236|Gammaproteobacteria,1X7TS@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
HFD2_k127_1907241_2	395495.Lcho_4059	9.15e-95	331.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KKRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Pkinase
HFD2_k127_1907241_6	663278.Ethha_2104	7.848e-12	70.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia,3WKK7@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HFD2_k127_1907241_5	1448860.BBJO01000074_gene1888	4.445e-18	96.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,23S8U@183963|Halobacteria	183963|Halobacteria	H	COG1985 Pyrimidine reductase, riboflavin biosynthesis	ribG	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
HFD2_k127_1921819_8	1538295.JY96_16385	4.307e-91	303.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,1KK2A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD2_k127_1921819_7	1265502.KB905934_gene3179	2.207e-93	314.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4ACAI@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HFD2_k127_1921819_4	1265502.KB905934_gene3178	2.372e-119	397.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,4ACGN@80864|Comamonadaceae	28216|Betaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
HFD2_k127_1921819_9	395495.Lcho_0956	2.657e-85	290.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1KKJU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	HAD-hyrolase-like	gph	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_1921819_10	216591.BCAM0605	3.313e-59	213.0	COG1522@1|root,COG1522@2|Bacteria,1MZ9D@1224|Proteobacteria,2VSJ1@28216|Betaproteobacteria,1K775@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_1921819_2	1276756.AUEX01000003_gene817	2.212e-167	532.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHIM@28216|Betaproteobacteria,4ABP6@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Ornithine cyclodeaminase mu-crystallin	arcB	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD2_k127_1921819_6	1366050.N234_12310	7.554e-96	322.0	COG2267@1|root,COG2267@2|Bacteria,1R72P@1224|Proteobacteria,2WH24@28216|Betaproteobacteria,1K5AI@119060|Burkholderiaceae	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_1921819_5	864051.BurJ1DRAFT_1260	5.68e-101	347.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KKDK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	gmr	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,MHYT
HFD2_k127_1921819_11	1100721.ALKO01000017_gene1771	4.224e-46	173.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,4AED8@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Blue (type 1) copper domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,CusF_Ec
HFD2_k127_1921819_13	1198452.Jab_2c04140	3.824e-23	108.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,47524@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	cusF	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
HFD2_k127_1921819_12	399795.CtesDRAFT_PD2385	1.345e-33	134.0	2EJB6@1|root,33D2A@2|Bacteria,1NPTN@1224|Proteobacteria,2VYN7@28216|Betaproteobacteria,4AIED@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_1921819_3	543728.Vapar_6301	6.995e-138	450.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,2VQKM@28216|Betaproteobacteria,4AEPD@80864|Comamonadaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_1921819_1	399795.CtesDRAFT_PD2380	1.051e-212	671.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,4ACXX@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
HFD2_k127_1921819_0	543728.Vapar_6299	0.0	1010.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HFD2_k127_1928115_6	983917.RGE_00570	2.457e-32	129.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,1KKMX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD2_k127_1928115_0	1265502.KB905947_gene1093	0.0	1080.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,4AAPK@80864|Comamonadaceae	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HFD2_k127_1928115_5	420662.Mpe_A3798	4.217e-46	171.0	COG2153@1|root,COG2153@2|Bacteria,1MZHA@1224|Proteobacteria,2VTYH@28216|Betaproteobacteria,1KMFG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Acetyltransferase (GNAT) domain	elaA	-	-	ko:K02348	-	-	-	-	ko00000	-	-	-	Acetyltransf_10
HFD2_k127_1928115_2	420662.Mpe_A3799	4.005e-133	435.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,2VP6Z@28216|Betaproteobacteria,1KIXJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3
HFD2_k127_1928115_3	420662.Mpe_A3800	4.715e-99	351.0	COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,2VPXN@28216|Betaproteobacteria,1KK76@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CP	ATPases associated with a variety of cellular activities	natA	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
HFD2_k127_1928115_1	987059.RBXJA2T_03958	8.084e-153	503.0	COG0596@1|root,COG2267@1|root,COG0596@2|Bacteria,COG2267@2|Bacteria,1R6KU@1224|Proteobacteria,2VMJU@28216|Betaproteobacteria,1KIYK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD2_k127_1928115_4	983917.RGE_00480	2.01e-49	179.0	COG0278@1|root,COG0278@2|Bacteria,1RKVH@1224|Proteobacteria,2VTC6@28216|Betaproteobacteria,1KNS9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HFD2_k127_1964079_1	1265502.KB905938_gene2424	3.471e-175	561.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQ9@28216|Betaproteobacteria,4AAAF@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HFD2_k127_1964079_4	159087.Daro_4007	2.43e-59	214.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,2VN1E@28216|Betaproteobacteria,2KUEP@206389|Rhodocyclales	206389|Rhodocyclales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_1964079_0	864051.BurJ1DRAFT_4851	1.847e-184	586.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HFD2_k127_1964079_3	864051.BurJ1DRAFT_4850	1.693e-157	503.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHHP@28216|Betaproteobacteria,1KIZR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_1964079_2	365044.Pnap_2870	1.793e-174	556.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_1968691_1	864051.BurJ1DRAFT_4795	2.314e-105	346.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,1KJ01@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	basic membrane	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HFD2_k127_1968691_0	1286631.X805_33440	2.177e-165	525.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VHBU@28216|Betaproteobacteria,1KJZ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_1968691_2	987059.RBXJA2T_04098	4.835e-75	254.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VH2R@28216|Betaproteobacteria,1KJQH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_1990291_7	909663.KI867150_gene1799	4.819e-26	115.0	COG1933@1|root,COG1933@2|Bacteria,1R1YB@1224|Proteobacteria	1224|Proteobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
HFD2_k127_1990291_2	1123504.JQKD01000008_gene5415	1.214e-111	366.0	COG4455@1|root,COG4455@2|Bacteria,1MWHI@1224|Proteobacteria,2VKHG@28216|Betaproteobacteria,4AD29@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM virulence protein, SciE type	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
HFD2_k127_1990291_6	1288494.EBAPG3_16500	3.33e-37	154.0	COG3518@1|root,COG3518@2|Bacteria,1RF51@1224|Proteobacteria,2VRQP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM type VI secretion system lysozyme-related protein	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
HFD2_k127_1990291_1	62928.azo3901	8.728e-199	638.0	COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,2VHXS@28216|Betaproteobacteria,2KWBQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Type VI secretion system, TssF	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
HFD2_k127_1990291_5	1288494.EBAPG3_16480	5.049e-91	323.0	COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,2VIIT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	type VI secretion protein	-	-	-	ko:K11895	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssG
HFD2_k127_1990291_0	1157708.KB907455_gene3461	0.0	1393.0	COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2VHSN@28216|Betaproteobacteria,4AAVS@80864|Comamonadaceae	28216|Betaproteobacteria	O	TIGRFAM type VI secretion ATPase, ClpV1 family	clpV	-	-	ko:K11907	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_1990291_4	765911.Thivi_2297	1.806e-98	349.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Rhs Element Vgr Protein	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
HFD2_k127_1990291_8	1408418.JNJH01000099_gene306	3.085e-09	71.0	COG1716@1|root,COG1716@2|Bacteria,1R7XU@1224|Proteobacteria,2UK8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Domain of unknown function (DUF4123)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4123
HFD2_k127_1990291_3	1123504.JQKD01000008_gene5436	6.116e-104	360.0	COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R3R7@1224|Proteobacteria,2VPTI@28216|Betaproteobacteria,4AEAN@80864|Comamonadaceae	28216|Betaproteobacteria	T	FHA domain	-	-	-	ko:K07169,ko:K11913	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko02044	-	-	-	FHA
HFD2_k127_2007493_11	644966.Tmar_1679	8.835e-25	106.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia,3WDNI@538999|Clostridiales incertae sedis	186801|Clostridia	V	daunorubicin resistance ABC transporter membrane protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_2007493_6	251229.Chro_0856	1.426e-69	243.0	COG1131@1|root,COG1131@2|Bacteria,1G1P6@1117|Cyanobacteria,3VHUZ@52604|Pleurocapsales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_2007493_8	338969.Rfer_0916	9.971e-50	182.0	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,4AF2I@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_2007493_7	338969.Rfer_3849	3.261e-61	217.0	COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,4AHJK@80864|Comamonadaceae	28216|Betaproteobacteria	J	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HFD2_k127_2007493_5	296591.Bpro_0930	2.073e-72	250.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,2VNI9@28216|Betaproteobacteria,4AEQI@80864|Comamonadaceae	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_2007493_12	29581.BW37_02163	2.101e-23	109.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,474R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
HFD2_k127_2007493_9	1123354.AUDR01000012_gene1723	2.472e-47	175.0	2DP14@1|root,3303I@2|Bacteria,1NEU1@1224|Proteobacteria,2VWRD@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2007493_10	1232410.KI421426_gene1417	9.784e-30	122.0	COG4274@1|root,COG4274@2|Bacteria,1N83R@1224|Proteobacteria,431NX@68525|delta/epsilon subdivisions,2WWPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_2007493_1	338969.Rfer_0829	5.267e-228	722.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,4AGM6@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HFD2_k127_2007493_0	1265502.KB905931_gene1671	0.0	1274.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,4A9P0@80864|Comamonadaceae	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD2_k127_2007493_2	983917.RGE_15150	1.679e-139	481.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,1KKEW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
HFD2_k127_2007493_4	864051.BurJ1DRAFT_3695	2.264e-108	370.0	COG2267@1|root,COG2267@2|Bacteria,1RFE1@1224|Proteobacteria,2VHIU@28216|Betaproteobacteria,1KJWK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HFD2_k127_2007493_3	420662.Mpe_A2845	3.106e-137	444.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,1KJSQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD2_k127_2013400_3	1286631.X805_27720	6.061e-59	205.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2VMAD@28216|Betaproteobacteria,1KJBD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	SMP-30 Gluconolaconase	-	-	3.1.1.15	ko:K13874,ko:K14274	ko00040,ko00053,ko01100,map00040,map00053,map01100	-	R02427,R02526	RC00537,RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
HFD2_k127_2013400_2	543728.Vapar_0729	2.056e-72	254.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2VQ4B@28216|Betaproteobacteria,4ADII@80864|Comamonadaceae	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD2_k127_2013400_0	983917.RGE_02310	1.586e-260	835.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KJNA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Cytochrome C biogenesis protein transmembrane region	-	-	1.8.1.8	ko:K04084,ko:K08344	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.5	-	-	DsbC,DsbD,Thioredoxin_7
HFD2_k127_2013400_4	420662.Mpe_A0190	1.35e-48	181.0	COG3312@1|root,COG3312@2|Bacteria,1RJ13@1224|Proteobacteria,2VT87@28216|Betaproteobacteria,1KM6R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
HFD2_k127_2013400_1	420662.Mpe_A0191	1.26e-160	509.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1KJR2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD2_k127_2013400_5	420662.Mpe_A0192	1.429e-40	152.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KMBR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD2_k127_2013400_6	420662.Mpe_A0193	4.698e-13	68.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,1KKTM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD2_k127_2034351_0	596154.Alide2_3908	1.919e-186	593.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD2_k127_2034351_5	596154.Alide2_3909	6.514e-103	336.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria,4AGHP@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HFD2_k127_2034351_12	1223521.BBJX01000002_gene2858	4.616e-17	83.0	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2VYHD@28216|Betaproteobacteria,4AIQ5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2034351_8	1223521.BBJX01000002_gene2857	1.647e-62	227.0	COG1612@1|root,COG1612@2|Bacteria,1NDQQ@1224|Proteobacteria,2VWPV@28216|Betaproteobacteria,4AGYI@80864|Comamonadaceae	28216|Betaproteobacteria	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HFD2_k127_2034351_7	452638.Pnec_1248	2.359e-69	250.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,1K5FE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 9	rfaQ	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_2034351_2	983917.RGE_07150	5.007e-124	402.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,1KKH6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_2034351_4	765914.ThisiDRAFT_1164	7.93e-110	375.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8
HFD2_k127_2034351_11	1255043.TVNIR_3350	3.194e-17	96.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_2034351_1	1123255.JHYS01000003_gene2933	1.377e-129	425.0	COG3621@1|root,COG3621@2|Bacteria,1R852@1224|Proteobacteria,2VM84@28216|Betaproteobacteria,4AEPA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_2034351_10	338969.Rfer_0408	8.284e-20	102.0	2E1DK@1|root,32WSU@2|Bacteria,1N3VJ@1224|Proteobacteria,2VV0D@28216|Betaproteobacteria,4AFV5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2034351_3	1159870.KB907784_gene3297	4.478e-111	366.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VM54@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_2034351_13	1500894.JQNN01000001_gene3220	9.558e-17	87.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WHDJ@28216|Betaproteobacteria,4794V@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_4,PAS_8,PAS_9,Response_reg
HFD2_k127_2034351_9	1288494.EBAPG3_12200	3.741e-24	114.0	COG2010@1|root,COG2010@2|Bacteria,1NF1C@1224|Proteobacteria,2VVP1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2034351_6	1175306.GWL_10430	8.507e-92	305.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VM67@28216|Betaproteobacteria,473H3@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Multicopper oxidase	copA_2	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
HFD2_k127_2037231_5	709797.CSIRO_3620	4.098e-50	179.0	COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2TQYY@28211|Alphaproteobacteria,3JSBD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_32450	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_2037231_6	29581.BW37_02604	7.124e-47	172.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2VTXT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_2037231_3	882378.RBRH_02002	2.257e-83	282.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2VMJ1@28216|Betaproteobacteria,1K0YD@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
HFD2_k127_2037231_7	1442599.JAAN01000013_gene3667	2.118e-09	62.0	COG0117@1|root,COG0307@1|root,COG1985@1|root,COG0117@2|Bacteria,COG0307@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1X30V@135614|Xanthomonadales	135614|Xanthomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD2_k127_2037231_0	1157708.KB907450_gene6147	2.84e-294	924.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4ABN8@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_2037231_4	420324.KI911947_gene5496	1.136e-56	213.0	COG2062@1|root,COG2062@2|Bacteria,1RIC8@1224|Proteobacteria,2U9B3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	phosphohistidine phosphatase, SixA	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_2037231_2	1157708.KB907450_gene5273	1.239e-136	441.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_2037231_1	1157708.KB907450_gene5271	2.981e-286	887.0	COG0129@1|root,COG0129@2|Bacteria,1N6EG@1224|Proteobacteria,2VK23@28216|Betaproteobacteria,4AGJX@80864|Comamonadaceae	28216|Betaproteobacteria	EG	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_2041839_3	290397.Adeh_2966	1.677e-104	350.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
HFD2_k127_2041839_7	404589.Anae109_2915	5.803e-69	241.0	COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,43AHK@68525|delta/epsilon subdivisions,2X5XT@28221|Deltaproteobacteria,2YVZ8@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2041839_5	404380.Gbem_3181	1.584e-90	329.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,43TPU@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
HFD2_k127_2041839_6	76114.ebA2022	2.807e-74	264.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,2KW28@206389|Rhodocyclales	206389|Rhodocyclales	L	NADH pyrophosphatase-like rudimentary NUDIX domain	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HFD2_k127_2041839_2	987059.RBXJA2T_03491	1.154e-108	363.0	COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2VMJD@28216|Betaproteobacteria,1KJRQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HFD2_k127_2041839_8	983917.RGE_29340	7.99e-32	127.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1KMII@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Cold shock protein	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_2041839_9	1504672.669787039	1.308e-14	78.0	2CDK0@1|root,32YHE@2|Bacteria,1NAHY@1224|Proteobacteria,2VWGS@28216|Betaproteobacteria,4AFT5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2041839_0	864051.BurJ1DRAFT_4976	9.148e-159	510.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VJSV@28216|Betaproteobacteria,1KKW3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Reductase C-terminal	thcD	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AIF_C,Pyr_redox_2,Reductase_C
HFD2_k127_2041839_1	365046.Rta_07160	9.032e-113	371.0	COG2129@1|root,COG2129@2|Bacteria,1MVNK@1224|Proteobacteria,2VPDN@28216|Betaproteobacteria,4AHDU@80864|Comamonadaceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_2041839_4	543728.Vapar_1652	3.974e-100	340.0	2DB86@1|root,2Z7QD@2|Bacteria,1MX4S@1224|Proteobacteria,2VKPI@28216|Betaproteobacteria,4AGQT@80864|Comamonadaceae	28216|Betaproteobacteria	S	Nucleotidyl transferase of unknown function (DUF2204)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HFD2_k127_2042613_3	395495.Lcho_0595	9.079e-110	374.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,1KJP1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HFD2_k127_2042613_4	420662.Mpe_A0652	9.734e-87	308.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,1KKNU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HFD2_k127_2042613_1	1265502.KB905932_gene1825	6.714e-146	479.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2VHYP@28216|Betaproteobacteria,4AACD@80864|Comamonadaceae	28216|Betaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HFD2_k127_2042613_2	983917.RGE_40990	1.93e-111	364.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,1KIXX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD2_k127_2042613_5	420662.Mpe_A0649	2.308e-50	181.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2VWEY@28216|Betaproteobacteria,1KMG1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
HFD2_k127_2042613_0	983917.RGE_41010	3.134e-161	514.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1KJ5S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD2_k127_2042613_6	1157708.KB907452_gene3547	9.179e-44	160.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,4AAZS@80864|Comamonadaceae	28216|Betaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD2_k127_2044311_4	1003200.AXXA_26210	2.106e-25	104.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5BW@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD3	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_2044311_0	1000565.METUNv1_01456	9.322e-100	332.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haloacid dehalogenase, type II	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HFD2_k127_2044311_6	864051.BurJ1DRAFT_3999	2.7e-10	70.0	295E1@1|root,2ZSRU@2|Bacteria,1P57E@1224|Proteobacteria,2W6KV@28216|Betaproteobacteria,1KP8T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2044311_3	509635.N824_24175	4.603e-30	124.0	2DB76@1|root,2Z7JZ@2|Bacteria,4NQDC@976|Bacteroidetes,1ISNB@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HFD2_k127_2044311_1	864051.BurJ1DRAFT_4309	2.942e-52	193.0	2BYGQ@1|root,32R3D@2|Bacteria,1QEGG@1224|Proteobacteria,2VT4X@28216|Betaproteobacteria,1KMA6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2726)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2726
HFD2_k127_2044311_2	983917.RGE_38610	7.5e-52	188.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSKZ@28216|Betaproteobacteria,1KM38@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	fkpA	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HFD2_k127_2044311_5	1538295.JY96_15095	2.575e-20	94.0	COG1256@1|root,COG1256@2|Bacteria,1NMP9@1224|Proteobacteria,2VVX1@28216|Betaproteobacteria,1KP7K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagella basal body rod protein	-	-	-	-	-	-	-	-	-	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD2_k127_2047177_3	314264.ROS217_05614	6.989e-49	201.0	COG1652@1|root,COG1652@2|Bacteria,1NMFX@1224|Proteobacteria,2UPIZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2047177_2	1342301.JASD01000002_gene3649	2.609e-52	192.0	2AKNA@1|root,31BES@2|Bacteria,1Q79C@1224|Proteobacteria,2VDDY@28211|Alphaproteobacteria,3ZWV6@60136|Sulfitobacter	28211|Alphaproteobacteria	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
HFD2_k127_2047177_1	420662.Mpe_A1809	2.303e-80	273.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2W9FK@28216|Betaproteobacteria,1KKMT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD2_k127_2047177_0	420662.Mpe_A1810	6.045e-249	781.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KK4D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD2_k127_2060418_2	1254432.SCE1572_47095	4.683e-187	586.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria	1224|Proteobacteria	G	Gluconolactonase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_2060418_3	1040986.ATYO01000010_gene3006	6.083e-144	463.0	COG1172@1|root,COG1172@2|Bacteria,1PRXF@1224|Proteobacteria,2TV5I@28211|Alphaproteobacteria,43H1C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_2060418_4	765698.Mesci_3056	8.702e-127	436.0	COG1172@1|root,COG1172@2|Bacteria,1MVKQ@1224|Proteobacteria,2TTT3@28211|Alphaproteobacteria,43JSW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_2060418_0	765698.Mesci_3055	1.414e-242	760.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,43MXA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA1	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HFD2_k127_2060418_1	1057002.KB905370_gene4026	2.664e-188	593.0	COG1879@1|root,COG1879@2|Bacteria,1MUEI@1224|Proteobacteria,2TUSR@28211|Alphaproteobacteria,4B948@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_2060418_5	296591.Bpro_3532	1.056e-82	275.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,4AAUE@80864|Comamonadaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.25,4.2.1.82,4.2.1.9	ko:K01687,ko:K13875,ko:K22186	ko00040,ko00053,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00053,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R02522,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_2082020_2	29581.BW37_03446	3.879e-44	178.0	2CIF8@1|root,32S7X@2|Bacteria,1N0AY@1224|Proteobacteria,2VUKS@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
HFD2_k127_2082020_0	420662.Mpe_A2014	4.465e-151	492.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1KJ6G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HFD2_k127_2082020_1	595537.Varpa_2153	5.493e-79	267.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,4AB7W@80864|Comamonadaceae	28216|Betaproteobacteria	S	transferase hexapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HFD2_k127_2082020_3	1266925.JHVX01000004_gene1140	3.561e-15	76.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,372U6@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01583	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HFD2_k127_2117962_5	1265502.KB905960_gene303	1.73e-24	104.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,4AC4U@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD2_k127_2117962_1	420662.Mpe_A3294	9.694e-123	401.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,1KJK6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_2117962_4	395495.Lcho_0114	8.378e-40	151.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2VVUD@28216|Betaproteobacteria,1KMNK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	TfoX N-terminal domain	tfoX	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
HFD2_k127_2117962_3	983917.RGE_04950	8.372e-82	276.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,1KK6Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	5-formyltetrahydrofolate cyclo-ligase	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD2_k127_2117962_2	983917.RGE_04970	8.603e-84	285.0	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2VR6Y@28216|Betaproteobacteria,1KKWE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	OmpW family	ompW	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HFD2_k127_2117962_0	864051.BurJ1DRAFT_4721	1.825e-150	482.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,1KJJJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HFD2_k127_2117962_6	338969.Rfer_0653	6.816e-16	78.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2VK8J@28216|Betaproteobacteria,4ABGG@80864|Comamonadaceae	28216|Betaproteobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD2_k127_2131616_6	1472716.KBK24_0111665	3.554e-110	359.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VK7N@28216|Betaproteobacteria,1K2DG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_2131616_1	543728.Vapar_3920	7.366e-259	809.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,4ACJV@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_2131616_4	864051.BurJ1DRAFT_3539	6.301e-144	467.0	COG2885@1|root,COG2885@2|Bacteria,1R4ZJ@1224|Proteobacteria,2VHJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_2131616_5	1218084.BBJK01000017_gene1840	9.758e-113	386.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KFC2@119060|Burkholderiaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4384,Pkinase
HFD2_k127_2131616_9	420662.Mpe_A2641	3.292e-75	254.0	COG3313@1|root,COG3313@2|Bacteria,1N711@1224|Proteobacteria,2VW2B@28216|Betaproteobacteria,1KKUM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3717)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289,DUF3717
HFD2_k127_2131616_2	983917.RGE_35160	4.345e-173	566.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2VH2B@28216|Betaproteobacteria,1KJU2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HFD2_k127_2131616_10	1116472.MGMO_55c00010	3.654e-71	256.0	COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria	1224|Proteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_2131616_13	864073.HFRIS_003963	3.038e-59	220.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,2VRDD@28216|Betaproteobacteria,472PX@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HFD2_k127_2131616_8	983917.RGE_18560	5.377e-77	273.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,1KKM0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ebsC	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HFD2_k127_2131616_3	395495.Lcho_2588	3.076e-160	529.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,1KJW3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldo/keto reductase family	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_2131616_11	279714.FuraDRAFT_1484	2.215e-70	262.0	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria,2WEV9@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N_3
HFD2_k127_2131616_14	472759.Nhal_0303	8.876e-57	215.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_2131616_16	631362.Thi970DRAFT_01806	1.01e-08	67.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,1S6FW@1236|Gammaproteobacteria,1WYIC@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2131616_15	1223521.BBJX01000005_gene1937	3.458e-55	198.0	COG2050@1|root,COG2050@2|Bacteria,1RHP8@1224|Proteobacteria,2VY16@28216|Betaproteobacteria,4AFY8@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_2131616_0	1265502.KB905929_gene2205	2.795e-293	919.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,4ACGG@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-binding enzyme	bclA_2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2131616_12	983917.RGE_18510	1.182e-65	241.0	COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,2WGJZ@28216|Betaproteobacteria,1KMVM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_2131616_7	1286631.X805_30790	1.7e-109	370.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIZ7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_216625_0	1288494.EBAPG3_23620	8.288e-209	654.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VNZD@28216|Betaproteobacteria,371WU@32003|Nitrosomonadales	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD2_k127_216625_3	1123392.AQWL01000010_gene2281	9.764e-79	292.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HFD2_k127_216625_2	439235.Dalk_5053	1.771e-83	311.0	COG0842@1|root,COG0842@2|Bacteria,1NG32@1224|Proteobacteria,43APA@68525|delta/epsilon subdivisions,2WMWG@28221|Deltaproteobacteria,2MMUI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HFD2_k127_216625_1	1123392.AQWL01000010_gene2283	1.102e-203	653.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,1KSCB@119069|Hydrogenophilales	119069|Hydrogenophilales	G	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_2172841_5	887062.HGR_13364	6.683e-56	196.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2VMHA@28216|Betaproteobacteria,4ACPB@80864|Comamonadaceae	28216|Betaproteobacteria	G	Periplasmic binding protein domain	xylF	-	-	ko:K10543,ko:K10546	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	Peripla_BP_4
HFD2_k127_2172841_1	864051.BurJ1DRAFT_3366	1.648e-244	763.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,1KKB9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	gguA	-	3.6.3.17	ko:K10441,ko:K10548	ko02010,map02010	M00212,M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.5	-	-	ABC_tran
HFD2_k127_2172841_2	864051.BurJ1DRAFT_3365	5.724e-178	590.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2VKBB@28216|Betaproteobacteria,1KMWU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	gguB	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
HFD2_k127_2172841_3	296591.Bpro_2837	3.284e-166	527.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2VIEI@28216|Betaproteobacteria,4AARS@80864|Comamonadaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.2.1.43,4.3.3.7	ko:K01714,ko:K13876	ko00053,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00053,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R02278,R10147	RC00429,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_2172841_0	1211115.ALIQ01000089_gene4457	3.001e-245	765.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	puuC	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_2172841_4	398578.Daci_5437	2.722e-66	238.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VK1U@28216|Betaproteobacteria,4ACNW@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2177916_3	395495.Lcho_0422	5.166e-40	154.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2VQBX@28216|Betaproteobacteria,1KKNE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_2177916_0	420662.Mpe_A3572	2.61e-309	955.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1KJIN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2177916_2	477184.KYC_15617	4.785e-84	286.0	COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2VP3Y@28216|Betaproteobacteria,3T6K2@506|Alcaligenaceae	28216|Betaproteobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_2177916_1	94624.Bpet3948	3.724e-84	284.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,3T6V0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_2198877_5	1458275.AZ34_13080	1.308e-63	218.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,4AA8E@80864|Comamonadaceae	28216|Betaproteobacteria	C	nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
HFD2_k127_2198877_3	1538295.JY96_01950	3.92e-99	332.0	COG3850@1|root,COG3850@2|Bacteria,1N23T@1224|Proteobacteria,2VQFG@28216|Betaproteobacteria,1KNYY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Type IV pili methyl-accepting chemotaxis transducer N-term	-	-	-	-	-	-	-	-	-	-	-	-	PilJ
HFD2_k127_2198877_4	1504672.669786515	1.129e-66	229.0	COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,4AEC0@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM nitrite reductase NAD(P)H , small subunit	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
HFD2_k127_2198877_0	543728.Vapar_3530	0.0	1364.0	COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,4AB7E@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nasA	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_2198877_1	1265502.KB905931_gene1689	2.909e-115	415.0	COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,2VH2D@28216|Betaproteobacteria,4AB5G@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glycosyl transferase, family	trpD3	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_2198877_2	1265502.KB905931_gene1688	7.369e-106	349.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,4AAU2@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the precorrin methyltransferase family	cobA	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
HFD2_k127_2198877_6	1123504.JQKD01000026_gene4250	1.499e-34	135.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VP54@28216|Betaproteobacteria,4AFR3@80864|Comamonadaceae	28216|Betaproteobacteria	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_2200267_0	420662.Mpe_A3103	0.0	1060.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1KISW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD2_k127_2200267_1	420662.Mpe_A3102	3.27e-288	889.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1KJRX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HFD2_k127_2200267_2	420662.Mpe_A3234	2.86e-254	802.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,1KJS4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HFD2_k127_2200267_3	983917.RGE_08770	1.012e-158	508.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,1KK6R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	TIGRFAM A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HFD2_k127_2200267_4	358220.C380_11485	3.59e-47	172.0	COG1349@1|root,COG1349@2|Bacteria,1MXW2@1224|Proteobacteria,2VJT9@28216|Betaproteobacteria,4AGQ8@80864|Comamonadaceae	28216|Betaproteobacteria	K	DeoR C terminal sensor domain	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
HFD2_k127_2203010_17	1265502.KB905935_gene3045	1.97e-72	246.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,4ABF3@80864|Comamonadaceae	28216|Betaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD2_k127_2203010_10	864051.BurJ1DRAFT_2931	6.496e-124	400.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,1KIUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD2_k127_2203010_12	420662.Mpe_A1974	4.263e-99	348.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,1KJZN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD2_k127_2203010_4	1286631.X805_04500	2.372e-181	574.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,1KJI9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD2_k127_2203010_3	420662.Mpe_A1972	7.389e-191	612.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1KJM6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HFD2_k127_2203010_1	420662.Mpe_A1971	0.0	1198.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1KJ34@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD2_k127_2203010_18	420662.Mpe_A1970	1.323e-66	231.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1KKYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the skp family	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD2_k127_2203010_6	1123504.JQKD01000032_gene4451	2.313e-142	458.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,4AAK8@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HFD2_k127_2203010_19	1100721.ALKO01000003_gene2150	4.269e-66	243.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,4ADIB@80864|Comamonadaceae	28216|Betaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HFD2_k127_2203010_9	1265502.KB905935_gene3036	5.517e-131	422.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,4AB4E@80864|Comamonadaceae	28216|Betaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HFD2_k127_2203010_5	1265502.KB905935_gene3035	1.523e-176	559.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,4A9M3@80864|Comamonadaceae	28216|Betaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HFD2_k127_2203010_16	365046.Rta_17570	9.534e-83	282.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,4AAT9@80864|Comamonadaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HFD2_k127_2203010_15	420662.Mpe_A1965	2.899e-90	307.0	COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,1KK2B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	rRNA methyltransferase	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_2203010_7	1265502.KB905935_gene3032	1.316e-141	458.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,4ABUX@80864|Comamonadaceae	28216|Betaproteobacteria	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	ydiA	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HFD2_k127_2203010_0	1265502.KB905935_gene3031	0.0	1355.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4AA18@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HFD2_k127_2203010_22	745310.G432_03510	6.525e-06	59.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,2K1X1@204457|Sphingomonadales	204457|Sphingomonadales	O	cytochrome c biogenesis	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_11,TPR_14,TPR_16,TPR_2
HFD2_k127_2203010_11	76114.ebA3702	1.631e-109	378.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,2M00Z@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_2203010_14	338969.Rfer_0800	1.351e-95	342.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4A9JG@80864|Comamonadaceae	28216|Betaproteobacteria	U	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD2_k127_2203010_2	748247.AZKH_4141	2.392e-200	633.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,2KUS2@206389|Rhodocyclales	206389|Rhodocyclales	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	FHA,T2SSE
HFD2_k127_2203010_13	338969.Rfer_0798	3.625e-97	332.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,4ADIP@80864|Comamonadaceae	28216|Betaproteobacteria	D	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,Response_reg
HFD2_k127_2203010_20	338969.Rfer_0797	4.088e-46	179.0	COG4961@1|root,COG4961@2|Bacteria,1N2QC@1224|Proteobacteria,2VTND@28216|Betaproteobacteria,4AIEE@80864|Comamonadaceae	28216|Betaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_2203010_21	76114.ebA3710	1.05e-31	141.0	COG4961@1|root,COG4961@2|Bacteria,1N1EM@1224|Proteobacteria,2VUTH@28216|Betaproteobacteria,2KXNN@206389|Rhodocyclales	206389|Rhodocyclales	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HFD2_k127_2203010_8	338969.Rfer_0795	2.32e-134	436.0	COG4961@1|root,COG4961@2|Bacteria,1R58C@1224|Proteobacteria,2VJAX@28216|Betaproteobacteria,4AJWH@80864|Comamonadaceae	28216|Betaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD2_k127_2244449_2	1123504.JQKD01000007_gene3343	1.038e-48	187.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VH58@28216|Betaproteobacteria,4AB0M@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_2244449_1	365046.Rta_27700	9.355e-85	295.0	COG2863@1|root,COG2863@2|Bacteria,1RGTS@1224|Proteobacteria,2VQDM@28216|Betaproteobacteria,4ACPF@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_2244449_3	666681.M301_1589	2.656e-44	180.0	COG4969@1|root,COG4969@2|Bacteria,1N4MN@1224|Proteobacteria,2VVHM@28216|Betaproteobacteria,2KNTC@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Pilin (bacterial filament)	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
HFD2_k127_2244449_0	395495.Lcho_0260	7.627e-145	466.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VIZP@28216|Betaproteobacteria,1KN6I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_2244449_4	864051.BurJ1DRAFT_3989	5.365e-08	56.0	COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,2VHT9@28216|Betaproteobacteria,1KK12@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the TPP enzyme family	gcl	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_2266118_5	420662.Mpe_A2051	3.625e-165	522.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1KJD5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HFD2_k127_2266118_7	983917.RGE_00860	1.528e-89	303.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,1KKPK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the ompA family	yiaD_1	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
HFD2_k127_2266118_0	983917.RGE_14510	9.507e-284	882.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ7I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_2266118_8	987059.RBXJA2T_07948	2.803e-49	182.0	COG1846@1|root,COG1846@2|Bacteria,1N7BV@1224|Proteobacteria,2VU53@28216|Betaproteobacteria,1KM8R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	marR	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_2266118_2	987059.RBXJA2T_07943	8.717e-178	578.0	COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,2VH6M@28216|Betaproteobacteria,1KKE1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_2266118_4	983917.RGE_40830	5.98e-172	561.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,1KJM0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	HlyD membrane-fusion protein of T1SS	emrA	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HFD2_k127_2266118_1	983917.RGE_40820	2.145e-262	816.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,1KIX6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	major facilitator superfamily	emrB	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HFD2_k127_2266118_6	420662.Mpe_A2048	1.207e-140	458.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,1KKI0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HFD2_k127_2266118_3	420662.Mpe_A2047	3.481e-174	559.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1KJGP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_2281095_0	420662.Mpe_A1285	1.042e-242	774.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,1KKD0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD2_k127_2281095_1	420662.Mpe_A2971	1.805e-24	106.0	COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,1KJ2N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	HDOD domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	HDOD,Pkinase
HFD2_k127_2290954_2	987059.RBXJA2T_03359	4.256e-85	287.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,1KJBS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD2_k127_2290954_3	1286631.X805_01130	1.926e-65	239.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1KKK3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HFD2_k127_2290954_0	420662.Mpe_A1573	7.456e-217	679.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,1KJSW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	risS	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
HFD2_k127_2290954_1	1538295.JY96_03260	3.363e-145	462.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,1KK5T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	ompR	-	-	ko:K02483,ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2293100_3	1000565.METUNv1_00486	3.76e-06	54.0	COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,2VIIW@28216|Betaproteobacteria,2KU7C@206389|Rhodocyclales	206389|Rhodocyclales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_2293100_1	420662.Mpe_A1639	2.016e-56	210.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2VSD1@28216|Betaproteobacteria,1KMHA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	MerR, DNA binding	cueR	-	-	ko:K19591,ko:K19592	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
HFD2_k127_2293100_0	420662.Mpe_A1640	0.0	1071.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KJVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HFD2_k127_2293100_2	935863.AWZR01000002_gene1088	2.041e-12	81.0	COG0457@1|root,COG0515@1|root,COG3063@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3063@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X52Q@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
HFD2_k127_2300378_15	1265502.KB905930_gene1546	6.508e-53	186.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,4AA00@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM isocitrate lyase and phosphorylmutase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HFD2_k127_2300378_13	1100720.ALKN01000040_gene2176	2.076e-67	239.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,4AJGK@80864|Comamonadaceae	28216|Betaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD2_k127_2300378_2	864051.BurJ1DRAFT_3583	1.9e-239	755.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1KJP9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Cys Met metabolism	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_2300378_4	543728.Vapar_2230	5.916e-168	531.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VKB5@28216|Betaproteobacteria,4AE4Y@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_2300378_3	196490.AUEZ01000044_gene6948	5.208e-175	558.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,3JRR8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_2300378_7	1380394.JADL01000002_gene1158	4.891e-132	445.0	COG4177@1|root,COG4177@2|Bacteria,1P0DF@1224|Proteobacteria,2TUBF@28211|Alphaproteobacteria,2JUXE@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HFD2_k127_2300378_5	1408164.MOLA814_02202	9.683e-137	442.0	COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2VPMF@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_2300378_10	1380394.JADL01000002_gene1160	6.301e-98	326.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2U1BU@28211|Alphaproteobacteria,2JW92@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_2300378_9	1408164.MOLA814_02200	7.756e-104	344.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VNH8@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_2300378_1	420662.Mpe_A1435	1.591e-318	981.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,1KJ4H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2300378_8	987059.RBXJA2T_13154	1.561e-111	384.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,1KJZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	fadB3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_2300378_16	987059.RBXJA2T_03406	2.122e-38	155.0	COG3137@1|root,COG3137@2|Bacteria,1N6XJ@1224|Proteobacteria,2VWDA@28216|Betaproteobacteria,1KNYK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Protein of unknown function, DUF481	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
HFD2_k127_2300378_12	358220.C380_06655	2.043e-78	286.0	COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,2VIMA@28216|Betaproteobacteria,4AB59@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_2300378_0	266264.Rmet_1146	4.8e-322	990.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,1K2GN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	DAO,ETF_QO,FAD_binding_2,NAD_binding_8
HFD2_k127_2300378_6	1265502.KB905936_gene2621	1.369e-132	436.0	COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,4AC2K@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	gno2	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_2300378_11	420662.Mpe_A1449	2.222e-80	273.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria,1KKKN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0502 family	yceH	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HFD2_k127_2300378_14	1265502.KB905936_gene2620	3.246e-66	229.0	COG0824@1|root,COG0824@2|Bacteria,1MZTU@1224|Proteobacteria,2VSY8@28216|Betaproteobacteria,4AE34@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase superfamily protein	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_2300378_17	395495.Lcho_1821	1.9e-35	139.0	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2WFXY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD2_k127_2316719_0	1265502.KB905943_gene2723	3.537e-160	521.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HFD2_k127_2316719_6	1265502.KB905943_gene2722	5.742e-29	129.0	COG3063@1|root,COG3063@2|Bacteria,1N7DT@1224|Proteobacteria,2VW37@28216|Betaproteobacteria,4AFTV@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2316719_5	395495.Lcho_2940	8.997e-44	170.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,1KM61@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	system-associated acyl-CoA thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HFD2_k127_2316719_1	420662.Mpe_A2954	7.747e-108	356.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1KK10@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HFD2_k127_2316719_4	864051.BurJ1DRAFT_1557	1.311e-54	194.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,1KM2W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HFD2_k127_2316719_3	420662.Mpe_A2956	2.515e-71	250.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria,1KKUN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	TonB C terminal	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HFD2_k127_2316719_2	420662.Mpe_A1385	2.606e-81	271.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1KJ35@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_2366872_2	420662.Mpe_A2756	3.07e-142	455.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,1KJWE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	phosphoesterase, PHP	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HFD2_k127_2366872_5	983917.RGE_21540	7.98e-116	381.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,1KJ0M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HFD2_k127_2366872_6	420662.Mpe_A2757	2.957e-115	374.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,1KKES@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the SUA5 family	yciO	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
HFD2_k127_2366872_3	983917.RGE_16700	1.19e-131	423.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,1KJFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HFD2_k127_2366872_0	420662.Mpe_A2631	0.0	1030.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1KJ7W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HFD2_k127_2366872_4	864051.BurJ1DRAFT_4824	6.055e-126	435.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,1KJQ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_2366872_7	1265502.KB905933_gene2051	1.619e-27	118.0	COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,4AFD9@80864|Comamonadaceae	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD2_k127_2366872_1	864051.BurJ1DRAFT_4822	3.519e-194	610.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,1KJBT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rieske 2Fe-2S	alcE	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_242234_3	983917.RGE_34210	6.056e-85	283.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,1KISX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD2_k127_242234_4	395495.Lcho_2329	1.006e-44	177.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2VU19@28216|Betaproteobacteria,1KMA1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_242234_2	1265502.KB905933_gene1982	7.043e-94	314.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,4ABGB@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HFD2_k127_242234_0	987059.RBXJA2T_18413	2.18e-167	550.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N9SU@1224|Proteobacteria,2VI30@28216|Betaproteobacteria,1KIV1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_242234_1	987059.RBXJA2T_18418	1.069e-128	416.0	COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,1KJE7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	ompR2	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_242234_5	420662.Mpe_A2644	7.972e-35	143.0	COG3678@1|root,COG3678@2|Bacteria,1NBYM@1224|Proteobacteria,2VXG9@28216|Betaproteobacteria,1KMIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
HFD2_k127_2431762_5	395495.Lcho_3807	2.271e-118	399.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,1KKEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
HFD2_k127_2431762_2	395495.Lcho_3806	1.023e-139	482.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,1KJAP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HFD2_k127_2431762_3	395495.Lcho_3805	6.648e-136	441.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,1KJ95@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	sulfate ABC transporter	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
HFD2_k127_2431762_1	420662.Mpe_A0123	4.905e-181	571.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,1KN2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HFD2_k127_2431762_0	420662.Mpe_A0122	6.678e-186	585.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,1KJR9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HFD2_k127_2431762_7	365046.Rta_33400	5.396e-78	271.0	COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,2VQK8@28216|Betaproteobacteria,4ADMB@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD2_k127_2431762_8	420662.Mpe_A0120	2.059e-74	265.0	COG3545@1|root,COG3545@2|Bacteria,1MZB5@1224|Proteobacteria,2VVMJ@28216|Betaproteobacteria,1KNKA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
HFD2_k127_2431762_10	983917.RGE_25370	1.21e-25	109.0	COG3585@1|root,COG3585@2|Bacteria,1N93I@1224|Proteobacteria,2VW0W@28216|Betaproteobacteria,1KNVN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	TOBE domain	ssuF	-	-	-	-	-	-	-	-	-	-	-	TOBE
HFD2_k127_2431762_11	614083.AWQR01000028_gene3171	1.412e-25	113.0	COG0526@1|root,COG0526@2|Bacteria,1N8B0@1224|Proteobacteria,2VW5T@28216|Betaproteobacteria,4AEW1@80864|Comamonadaceae	28216|Betaproteobacteria	CO	PFAM Thioredoxin	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Thioredoxin
HFD2_k127_2431762_6	983917.RGE_25420	3.373e-112	383.0	COG1116@1|root,COG1116@2|Bacteria,1MUKI@1224|Proteobacteria,2VMBI@28216|Betaproteobacteria,1KMW3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system	ssuB	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
HFD2_k127_2431762_4	983917.RGE_25410	9.769e-129	419.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VJ3H@28216|Betaproteobacteria,1KMYN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	ssuC	-	-	ko:K02050,ko:K15554	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	BPD_transp_1
HFD2_k127_2431762_9	983917.RGE_25400	4.536e-39	146.0	COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2VI2J@28216|Betaproteobacteria,1KMXS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Catalyzes the desulfonation of aliphatic sulfonates	ssuD	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
HFD2_k127_2468967_0	1286631.X805_31190	2.334e-96	321.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VQD1@28216|Betaproteobacteria,1KKUH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_2468967_2	342113.DM82_3038	1.019e-66	246.0	COG1664@1|root,COG1664@2|Bacteria,1MUS9@1224|Proteobacteria	1224|Proteobacteria	M	Type ii and iii secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD2_k127_2468967_1	420662.Mpe_A3528	2.95e-82	278.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,1KKH7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD2_k127_2489244_10	983917.RGE_07500	1.364e-12	77.0	COG2906@1|root,COG2906@2|Bacteria	2|Bacteria	P	2 iron, 2 sulfur cluster binding	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
HFD2_k127_2489244_4	1100721.ALKO01000036_gene2757	3.443e-150	484.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria,4AC8S@80864|Comamonadaceae	28216|Betaproteobacteria	S	Fad dependent oxidoreductase	lhgO	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_2489244_5	420662.Mpe_A1468	2.536e-139	458.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,1KK3Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HFD2_k127_2489244_6	420662.Mpe_A1469	8.618e-103	340.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,1KJE1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HFD2_k127_2489244_1	395495.Lcho_1193	1.856e-228	711.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2VHDV@28216|Betaproteobacteria,1KIUX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_2489244_2	543728.Vapar_4884	9.276e-222	699.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHEI@28216|Betaproteobacteria,4AC9Q@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2489244_7	1156919.QWC_25242	9.421e-100	333.0	COG0730@1|root,COG0730@2|Bacteria,1PJR4@1224|Proteobacteria,2VHUT@28216|Betaproteobacteria,3T3J0@506|Alcaligenaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_2489244_9	1504672.669783719	1.191e-18	100.0	COG5652@1|root,COG5652@2|Bacteria,1N9QA@1224|Proteobacteria,2VW74@28216|Betaproteobacteria,4AFP6@80864|Comamonadaceae	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HFD2_k127_2489244_0	1157708.KB907457_gene2662	1.016e-250	784.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMNC@28216|Betaproteobacteria,4AD5V@80864|Comamonadaceae	28216|Betaproteobacteria	H	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD2_k127_2489244_8	1005048.CFU_2018	1.064e-59	211.0	COG5002@1|root,COG5002@2|Bacteria,1RI2X@1224|Proteobacteria,2WGVH@28216|Betaproteobacteria,474ZU@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS
HFD2_k127_2489244_3	296591.Bpro_2801	1.457e-205	640.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHYG@28216|Betaproteobacteria,4AB4X@80864|Comamonadaceae	28216|Betaproteobacteria	C	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD2_k127_2494348_9	1458357.BG58_27170	8.323e-31	121.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,1JZT8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD2_k127_2494348_0	983917.RGE_45100	3.493e-175	552.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,1KJRW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HFD2_k127_2494348_4	1265502.KB905939_gene2341	2.901e-83	284.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,4ADFG@80864|Comamonadaceae	28216|Betaproteobacteria	G	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HFD2_k127_2494348_6	420662.Mpe_A0226	3.373e-54	201.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,1KM2I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	sigma 54 modulation protein ribosomal protein S30EA	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HFD2_k127_2494348_1	864051.BurJ1DRAFT_4636	2.4e-171	543.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2VHH3@28216|Betaproteobacteria,1KKB3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD2_k127_2494348_7	420662.Mpe_A0229	8.806e-54	211.0	COG3631@1|root,COG3631@2|Bacteria,1MZS5@1224|Proteobacteria,2VSD2@28216|Betaproteobacteria,1KM0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
HFD2_k127_2494348_3	420662.Mpe_A0230	3.184e-106	349.0	COG4221@1|root,COG4221@2|Bacteria,1R9DN@1224|Proteobacteria,2WGRS@28216|Betaproteobacteria,1KJCX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_2494348_5	983917.RGE_44950	2.598e-71	265.0	2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,2VRS4@28216|Betaproteobacteria,1KKJ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
HFD2_k127_2494348_2	420662.Mpe_A0232	1.216e-163	533.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,1KK9I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
HFD2_k127_2494348_8	420662.Mpe_A0233	3.962e-50	183.0	COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,1KMBH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HFD2_k127_2510795_2	420662.Mpe_A3737	4.257e-165	523.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,1KJNN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD2_k127_2510795_3	194867.ALBQ01000019_gene3665	1.622e-157	501.0	COG0451@1|root,COG0451@2|Bacteria,1QP8J@1224|Proteobacteria,2U09V@28211|Alphaproteobacteria,2K1VA@204457|Sphingomonadales	204457|Sphingomonadales	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_2510795_7	404380.Gbem_1505	4.151e-89	327.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
HFD2_k127_2510795_10	1349767.GJA_3786	1.019e-19	98.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,2VVST@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
HFD2_k127_2510795_4	1249480.B649_09535	1.675e-112	389.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2YN51@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	receptor	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
HFD2_k127_2510795_5	1123504.JQKD01000018_gene2053	4.205e-106	359.0	28H8Z@1|root,2ZC05@2|Bacteria,1RBDW@1224|Proteobacteria,2VRPB@28216|Betaproteobacteria,4AEA6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HFD2_k127_2510795_11	1157708.KB907466_gene659	2.266e-13	83.0	2CH9M@1|root,332CJ@2|Bacteria,1N7TS@1224|Proteobacteria,2VX3H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2510795_1	1265502.KB905944_gene690	5.028e-168	546.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,4A9KZ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_2510795_0	1538295.JY96_14995	8.422e-289	890.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,1KJHE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Has an organic peroxide-dependent peroxidase activity	katA2	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
HFD2_k127_2510795_8	983917.RGE_00910	9.91e-88	293.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2VHJI@28216|Betaproteobacteria,1KK3I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HFD2_k127_2510795_9	1245471.PCA10_34820	1.031e-75	285.0	COG0693@1|root,COG0693@2|Bacteria,1MYS4@1224|Proteobacteria,1RZUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DJ-1 PfpI family protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HFD2_k127_2510795_6	404589.Anae109_0505	8.834e-97	321.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_2568999_4	395495.Lcho_1843	1.174e-121	392.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,1KIY7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	alkK	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_2568999_0	1100721.ALKO01000003_gene2411	3.616e-222	699.0	COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,4AAZP@80864|Comamonadaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_2568999_2	420662.Mpe_A1771	1.19e-158	506.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJAM@28216|Betaproteobacteria,1KJNC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_2568999_1	1100720.ALKN01000045_gene83	1.515e-210	660.0	COG4177@1|root,COG4177@2|Bacteria,1MY3V@1224|Proteobacteria,2VJIE@28216|Betaproteobacteria,4A9KX@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_2568999_3	1265502.KB905940_gene3001	2.353e-132	425.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VIKW@28216|Betaproteobacteria,4ACDN@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_2568999_5	864051.BurJ1DRAFT_2270	1.509e-43	173.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VINK@28216|Betaproteobacteria,1KJAD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_257994_7	1366050.N234_15900	2.624e-41	169.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,1K063@119060|Burkholderiaceae	28216|Betaproteobacteria	T	domain protein	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	DUF2222,EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9
HFD2_k127_257994_0	864051.BurJ1DRAFT_2680	0.0	1373.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,1KITN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Orn Lys Arg decarboxylase	adi	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
HFD2_k127_257994_6	1223521.BBJX01000004_gene2469	1.977e-41	158.0	COG1585@1|root,COG1585@2|Bacteria,1N474@1224|Proteobacteria,2VWDX@28216|Betaproteobacteria,4AEIX@80864|Comamonadaceae	28216|Betaproteobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HFD2_k127_257994_2	1265502.KB905930_gene1517	1.935e-144	473.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,4AA2E@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Band 7 protein	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HFD2_k127_257994_1	365044.Pnap_1228	4.047e-208	666.0	COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,4AA9C@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Sulfatase	-	-	2.7.8.43	ko:K03760	ko01503,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DUF1705,Sulfatase
HFD2_k127_257994_5	358220.C380_22615	7.597e-76	267.0	COG3907@1|root,COG3907@2|Bacteria,1MU4M@1224|Proteobacteria,2VQKI@28216|Betaproteobacteria,4ADPN@80864|Comamonadaceae	28216|Betaproteobacteria	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD2_k127_257994_4	358220.C380_22610	5.003e-89	307.0	COG0745@1|root,COG0745@2|Bacteria,1NV31@1224|Proteobacteria,2VJ12@28216|Betaproteobacteria,4AAH5@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_257994_3	358220.C380_22605	5.197e-125	415.0	COG0642@1|root,COG0642@2|Bacteria,1R4WN@1224|Proteobacteria,2VJA6@28216|Betaproteobacteria,4ABR2@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HisKA
HFD2_k127_2608695_1	1470591.BW41_03312	9.136e-275	861.0	COG0265@1|root,COG0265@2|Bacteria,1N924@1224|Proteobacteria	1224|Proteobacteria	O	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HFD2_k127_2608695_0	1282362.AEAC466_10855	5.709e-276	866.0	COG1874@1|root,COG1874@2|Bacteria,1MUVR@1224|Proteobacteria,2TTC5@28211|Alphaproteobacteria,2KJ50@204458|Caulobacterales	204458|Caulobacterales	G	Beta-galactosidase trimerisation domain	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
HFD2_k127_2608695_5	452637.Oter_3284	1.057e-14	80.0	COG2909@1|root,COG3710@1|root,COG2909@2|Bacteria,COG3710@2|Bacteria,46UY3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_2608695_2	452637.Oter_1756	1.109e-99	344.0	COG1609@1|root,COG1609@2|Bacteria,46UIZ@74201|Verrucomicrobia,3K8BK@414999|Opitutae	414999|Opitutae	K	Periplasmic binding protein domain	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD2_k127_2608695_4	194867.ALBQ01000018_gene2541	7.977e-23	108.0	COG3664@1|root,COG3664@2|Bacteria,1MWYX@1224|Proteobacteria,2U2MC@28211|Alphaproteobacteria,2K19N@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
HFD2_k127_2608695_3	1500894.JQNN01000001_gene774	1.032e-28	120.0	COG2271@1|root,COG2271@2|Bacteria,1QZGJ@1224|Proteobacteria	1224|Proteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HFD2_k127_2632321_2	987059.RBXJA2T_03733	2.014e-222	727.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1KJ09@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77
HFD2_k127_2632321_0	864051.BurJ1DRAFT_1987	3.202e-308	966.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1KKEV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HFD2_k127_2632321_1	987059.RBXJA2T_03723	3.233e-243	757.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,1KKCY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_2632321_3	365044.Pnap_1107	2.548e-217	684.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,4ACAA@80864|Comamonadaceae	28216|Betaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD2_k127_2639164_6	1007105.PT7_2263	4.942e-13	73.0	COG4625@1|root,COG4625@2|Bacteria,1N4H5@1224|Proteobacteria,2VPI3@28216|Betaproteobacteria,3T3F0@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein with a C-terminal OMP (outer membrane protein) domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
HFD2_k127_2639164_4	543728.Vapar_3337	3.294e-121	409.0	COG2084@1|root,COG2084@2|Bacteria,1NS71@1224|Proteobacteria,2VMNQ@28216|Betaproteobacteria,4AHTD@80864|Comamonadaceae	28216|Betaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_2639164_3	1157708.KB907465_gene318	3.339e-124	402.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,4AD9N@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	KR domain	kduD	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_2639164_2	1157708.KB907465_gene317	9.096e-138	444.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VIVP@28216|Betaproteobacteria,4AA44@80864|Comamonadaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_2639164_0	543728.Vapar_3340	1.14e-173	568.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,4AJ6Y@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_2639164_1	1157708.KB907465_gene302	4.015e-169	538.0	COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2VPGY@28216|Betaproteobacteria,4AJ5S@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K06145	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HFD2_k127_2639164_5	1157708.KB907465_gene301	2.277e-76	259.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2VK61@28216|Betaproteobacteria,4ABNM@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase LRE domain protein	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_2651229_1	395495.Lcho_1141	4.875e-156	495.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,2VGZR@28216|Betaproteobacteria,1KJ87@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Permease family	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
HFD2_k127_2651229_0	395495.Lcho_1140	2.195e-236	752.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,1KJED@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Amidohydrolase family	atzB	-	3.5.4.32	ko:K18456	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_1
HFD2_k127_2651229_5	1123504.JQKD01000002_gene3754	1.273e-96	335.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_2651229_4	395495.Lcho_4067	7.441e-114	374.0	COG2770@1|root,COG2770@2|Bacteria,1QZYS@1224|Proteobacteria,2VJTC@28216|Betaproteobacteria,1KJFF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
HFD2_k127_2651229_7	1123504.JQKD01000002_gene3752	6.66e-56	209.0	2BWWN@1|root,32XHS@2|Bacteria,1N289@1224|Proteobacteria,2VU35@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_2651229_3	1123504.JQKD01000027_gene4105	1.99e-121	394.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VKWQ@28216|Betaproteobacteria,4AHJP@80864|Comamonadaceae	28216|Betaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD2_k127_2651229_12	1123504.JQKD01000027_gene4104	2.412e-23	111.0	COG1942@1|root,COG1942@2|Bacteria,1N8I6@1224|Proteobacteria,2VW8C@28216|Betaproteobacteria,4AFEI@80864|Comamonadaceae	28216|Betaproteobacteria	G	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HFD2_k127_2651229_11	864051.BurJ1DRAFT_4729	1.904e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,1NXIZ@1224|Proteobacteria,2W3AS@28216|Betaproteobacteria,1KNT9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_2651229_8	543728.Vapar_3633	1.433e-49	184.0	COG0789@1|root,COG0789@2|Bacteria,1N9C6@1224|Proteobacteria,2VW38@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transcriptional regulator, merr family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_2651229_6	1218084.BBJK01000001_gene64	1.207e-75	264.0	COG3832@1|root,COG3832@2|Bacteria,1RD0P@1224|Proteobacteria,2VS78@28216|Betaproteobacteria,1K76G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_2651229_9	543728.Vapar_3634	1.656e-46	172.0	COG3631@1|root,COG3631@2|Bacteria,1RDZR@1224|Proteobacteria,2VXTH@28216|Betaproteobacteria,4AIEP@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HFD2_k127_2651229_2	666681.M301_2174	4.634e-132	427.0	COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,2VTNJ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	SPFH domain Band 7 family	hflC_1	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_2651229_10	1500894.JQNN01000001_gene3127	1.51e-40	156.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria,4768Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HATPase_c,HisKA,Response_reg
HFD2_k127_2656123_2	864051.BurJ1DRAFT_4798	2.033e-108	357.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,1KJQ1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_2656123_0	864051.BurJ1DRAFT_4800	1.286e-209	660.0	COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2VJN1@28216|Betaproteobacteria,1KJPU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Guanine deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD2_k127_2656123_1	420662.Mpe_A0800	4.131e-134	436.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VJ6D@28216|Betaproteobacteria,1KJXD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_265987_1	1286631.X805_22820	4.009e-47	170.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1KJQF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD2_k127_265987_0	987059.RBXJA2T_04468	1.539e-54	193.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,1KM4M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD2_k127_265987_3	1380391.JIAS01000012_gene4259	2.441e-15	92.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria,2JWIY@204441|Rhodospirillales	204441|Rhodospirillales	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD2_k127_265987_2	330214.NIDE0214	5.215e-29	136.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K19231	-	-	-	-	ko00000,ko02000	1.B.12	-	-	ESPR,PATR
HFD2_k127_2670054_4	983917.RGE_30170	9.15e-55	198.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
HFD2_k127_2670054_0	365046.Rta_12270	1.842e-202	636.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VHTW@28216|Betaproteobacteria,4AAJM@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	TIGRFAM Drug resistance transporter Bcr CflA subfamily	bcr	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HFD2_k127_2670054_1	864051.BurJ1DRAFT_4843	1.059e-118	392.0	COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,1KJIB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Eukaryotic-type carbonic anhydrase	ecaA	-	4.2.1.1	ko:K01674	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Carb_anhydrase
HFD2_k127_2670054_3	420662.Mpe_A0531	3.289e-60	217.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,1KKYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Hemolysin III	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HFD2_k127_2670054_2	296591.Bpro_2738	3.19e-103	338.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2WC2E@28216|Betaproteobacteria,4AIRV@80864|Comamonadaceae	28216|Betaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HFD2_k127_2694999_9	864051.BurJ1DRAFT_3510	2.005e-29	119.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,1KM7P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD TolR	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD2_k127_2694999_2	864051.BurJ1DRAFT_3511	6.3e-118	389.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,1KJ4E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HFD2_k127_2694999_10	762376.AXYL_04144	4.591e-19	89.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,3T4SY@506|Alcaligenaceae	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HFD2_k127_2694999_1	1286631.X805_04000	5.233e-118	384.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,1KJA1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HFD2_k127_2694999_3	1265502.KB905930_gene1454	1.159e-115	377.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,4AAQG@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD2_k127_2694999_0	1265502.KB905930_gene1440	1.099e-131	428.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VHU8@28216|Betaproteobacteria,4ABDR@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	fabG3	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD2_k127_2694999_5	395495.Lcho_3231	5.463e-96	334.0	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2VKBS@28216|Betaproteobacteria,1KJ62@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HFD2_k127_2694999_7	29581.BW37_03560	3.759e-58	205.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2VT16@28216|Betaproteobacteria,474QN@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD2_k127_2694999_8	864051.BurJ1DRAFT_1595	1.65e-55	197.0	COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,2VSF4@28216|Betaproteobacteria,1KM48@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD2_k127_2694999_4	1005048.CFU_3174	1.208e-102	343.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,472IN@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	MotA/TolQ/ExbB proton channel family	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HFD2_k127_2694999_6	395495.Lcho_3235	1.203e-62	224.0	COG0810@1|root,COG0810@2|Bacteria,1RJRA@1224|Proteobacteria,2VTFA@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_271048_4	1286093.C266_23021	9.322e-40	148.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1K0VF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD2_k127_271048_0	864051.BurJ1DRAFT_2871	1.997e-156	513.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria,1KKYK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HFD2_k127_271048_2	983917.RGE_34260	1.624e-74	258.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria,1KKX6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K13053,ko:K14160	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	SulA
HFD2_k127_271048_1	331869.BAL199_19923	4.406e-104	347.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,2TY45@28211|Alphaproteobacteria,4BSRG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HFD2_k127_271048_3	395495.Lcho_2653	3.322e-44	180.0	COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,2VTZE@28216|Betaproteobacteria,1KMBC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0225 family	ychJ	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
HFD2_k127_2718676_6	987059.RBXJA2T_07568	6.635e-104	345.0	COG1639@1|root,COG1639@2|Bacteria,1PQZH@1224|Proteobacteria,2VQK4@28216|Betaproteobacteria,1KKZB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	signal transduction protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
HFD2_k127_2718676_1	987059.RBXJA2T_07573	4.913e-234	738.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD2_k127_2718676_5	305700.B447_01381	2.398e-125	421.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,2KUTA@206389|Rhodocyclales	206389|Rhodocyclales	U	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HFD2_k127_2718676_4	1265502.KB905937_gene2542	1.698e-154	497.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_2718676_0	983917.RGE_46830	3.29e-262	836.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1KJMZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	-	-	ko:K02031,ko:K02032,ko:K10823,ko:K13896,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00349,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.21,3.A.1.5.24,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_2718676_2	864051.BurJ1DRAFT_4999	6.074e-168	539.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,1KKHI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_2718676_3	864051.BurJ1DRAFT_4998	7.724e-166	531.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VN7U@28216|Betaproteobacteria,1KJSF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	gsiC_8	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2718676_7	864051.BurJ1DRAFT_4997	4.035e-33	133.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KJPX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_2721133_10	1207063.P24_04300	8.269e-62	231.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2JZD9@204441|Rhodospirillales	204441|Rhodospirillales	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HFD2_k127_2721133_9	251221.35213336	2.025e-103	353.0	COG1718@1|root,COG1718@2|Bacteria,1G3HN@1117|Cyanobacteria	1117|Cyanobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2721133_12	1123073.KB899241_gene2289	1.222e-43	167.0	2CP0Z@1|root,32SI8@2|Bacteria,1RK5X@1224|Proteobacteria,1T6RI@1236|Gammaproteobacteria,1X7ZQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
HFD2_k127_2721133_8	395495.Lcho_2496	6.235e-108	379.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2VJI6@28216|Betaproteobacteria,1KJNV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HFD2_k127_2721133_1	395495.Lcho_2497	2.946e-273	854.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2VHXI@28216|Betaproteobacteria,1KK9X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD2_k127_2721133_13	1276756.AUEX01000007_gene1389	2.171e-34	147.0	2CC0C@1|root,32RUG@2|Bacteria,1MZVQ@1224|Proteobacteria,2VUAQ@28216|Betaproteobacteria,4AEUG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3297)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3297
HFD2_k127_2721133_5	29581.BW37_03744	6.806e-167	559.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,472HS@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
HFD2_k127_2721133_11	697282.Mettu_1650	6.712e-60	228.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1TI9E@1236|Gammaproteobacteria,1XF6R@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
HFD2_k127_2721133_0	443143.GM18_1888	0.0	1119.0	COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,43CB5@68525|delta/epsilon subdivisions,2WU0Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_2721133_4	1380394.JADL01000005_gene5542	8.384e-170	571.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TQRF@28211|Alphaproteobacteria,2JSZU@204441|Rhodospirillales	204441|Rhodospirillales	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HFD2_k127_2721133_3	977880.RALTA_A1656	7.989e-187	591.0	COG3970@1|root,COG3970@2|Bacteria,1MVA2@1224|Proteobacteria,2VIXV@28216|Betaproteobacteria,1K3XI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_2721133_6	395495.Lcho_2507	1.996e-145	499.0	COG0820@1|root,COG0820@2|Bacteria,1Q0HH@1224|Proteobacteria,2VMGJ@28216|Betaproteobacteria,1KJ7U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the radical SAM superfamily. RlmN family	rlmN_2	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD2_k127_2721133_7	420662.Mpe_A1811	8.894e-131	426.0	COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,1KK6I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	-	-	-	-	-	-	-	-	-	ZipA_C
HFD2_k127_2721133_2	420662.Mpe_A1810	1.125e-207	652.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KK4D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD2_k127_2724238_18	420662.Mpe_A0292	7.386e-14	84.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,1KJ3Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	phosphoribosylaminoimidazole-succinocarboxamide synthase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD2_k127_2724238_15	1286631.X805_22330	5.967e-40	164.0	COG0457@1|root,COG0457@2|Bacteria,1RGF8@1224|Proteobacteria,2VS52@28216|Betaproteobacteria,1KKV1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2724238_5	1265502.KB905959_gene263	3.154e-132	429.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,4AA97@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Thioredoxin domain	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD2_k127_2724238_9	1268622.AVS7_03130	3.673e-73	251.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,4ADQH@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HFD2_k127_2724238_2	365046.Rta_36740	1.116e-163	532.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,4AAU4@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HFD2_k127_2724238_6	864051.BurJ1DRAFT_4278	1.136e-121	409.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,1KIY9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	rimN	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HFD2_k127_2724238_11	420662.Mpe_A0298	3.959e-60	221.0	COG3240@1|root,COG3240@2|Bacteria,1RI6H@1224|Proteobacteria,2VTGG@28216|Betaproteobacteria,1KM0N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	lipase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2724238_3	1123504.JQKD01000003_gene653	2.832e-161	536.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,4AARG@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HFD2_k127_2724238_10	987059.RBXJA2T_06325	2.836e-60	234.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2VQR7@28216|Betaproteobacteria,1KM57@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Peptidase M22, glycoprotease	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HFD2_k127_2724238_13	864051.BurJ1DRAFT_4273	6.59e-48	183.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,1KMG3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789,ko:K14742	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HFD2_k127_2724238_7	1286631.X805_35900	5.099e-96	332.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1KK3N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	uracil-DNA glycosylase	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_2724238_0	420662.Mpe_A0304	1.625e-295	935.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KK8G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
HFD2_k127_2724238_1	1286631.X805_14360	3.101e-213	671.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,1KJ21@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
HFD2_k127_2724238_12	420662.Mpe_A0556	5.169e-50	189.0	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,2VR1F@28216|Betaproteobacteria,1KKTB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2724238_17	261292.Nit79A3_3006	5.554e-30	122.0	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,2VR1F@28216|Betaproteobacteria,3737K@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2724238_14	864051.BurJ1DRAFT_4268	1.975e-47	177.0	2C0PG@1|root,330E3@2|Bacteria,1RA6M@1224|Proteobacteria,2VU13@28216|Betaproteobacteria,1KMG8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD2_k127_2724238_4	420662.Mpe_A0554	1.308e-151	497.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,1KJ0F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HFD2_k127_2724238_8	864051.BurJ1DRAFT_4264	6.117e-94	336.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,1KJUW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HFD2_k127_2738439_3	420662.Mpe_A1222	2.407e-156	499.0	COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria	1224|Proteobacteria	I	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HFD2_k127_2738439_8	420662.Mpe_A1223	1.647e-75	273.0	2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,2W1BJ@28216|Betaproteobacteria,1KNAC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738439_2	864051.BurJ1DRAFT_1742	1.663e-188	607.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,2VZB4@28216|Betaproteobacteria,1KN0Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738439_0	420662.Mpe_A1225	0.0	1292.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,2VZ4H@28216|Betaproteobacteria,1KN47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_2738439_9	420662.Mpe_A1226	9.661e-74	259.0	COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,2W9UY@28216|Betaproteobacteria,1KNVB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
HFD2_k127_2738439_12	420662.Mpe_A1227	1.078e-32	139.0	2AHZN@1|root,318CZ@2|Bacteria,1Q06K@1224|Proteobacteria,2W4WA@28216|Betaproteobacteria,1KNW5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738439_7	420662.Mpe_A1228	7.249e-108	359.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,2W1K9@28216|Betaproteobacteria,1KN6K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HFD2_k127_2738439_10	420662.Mpe_A1229	8.043e-59	209.0	COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,2W2ZB@28216|Betaproteobacteria,1KNMZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HFD2_k127_2738439_11	420662.Mpe_A1230	1.638e-57	213.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,2W30E@28216|Betaproteobacteria,1KNKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HFD2_k127_2738439_5	420662.Mpe_A1231	6.154e-129	430.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,2W055@28216|Betaproteobacteria,1KNG4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2738439_1	420662.Mpe_A2141	3.283e-254	790.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1KIW5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_2738439_6	1286631.X805_02570	8.586e-120	394.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VPK7@28216|Betaproteobacteria,1KKX1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	rfaC	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_2738439_4	864051.BurJ1DRAFT_2519	4.612e-134	451.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,1KK38@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	transferase	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
HFD2_k127_2741024_0	358220.C380_06990	2.119e-231	748.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,4ABE6@80864|Comamonadaceae	28216|Betaproteobacteria	S	alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
HFD2_k127_2741024_1	864051.BurJ1DRAFT_4938	3.977e-157	517.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1KKB2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase family M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
HFD2_k127_2741024_2	987059.RBXJA2T_13449	2.031e-76	263.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,1KKXV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HFD2_k127_2741024_3	983917.RGE_46450	1.244e-43	164.0	COG3307@1|root,COG3307@2|Bacteria,1MYWJ@1224|Proteobacteria,2VKHZ@28216|Betaproteobacteria,1KJJW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Virulence factor membrane-bound polymerase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PglL_A,Wzy_C,Wzy_C_2
HFD2_k127_2745590_1	864051.BurJ1DRAFT_4801	5.393e-162	517.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2VI0J@28216|Betaproteobacteria,1KK2T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Xanthine dehydrogenase small subunit	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HFD2_k127_2745590_0	543728.Vapar_3906	0.0	1290.0	COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2VHYR@28216|Betaproteobacteria,4AB6W@80864|Comamonadaceae	28216|Betaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_2745590_2	864051.BurJ1DRAFT_4803	8.83e-89	329.0	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2VKME@28216|Betaproteobacteria,1KJ5R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	TIGRFAM xanthine dehydrogenase accessory protein XdhC	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD2_k127_2745590_3	380703.AHA_3506	1.725e-14	78.0	COG0842@1|root,COG0842@2|Bacteria,1R4QG@1224|Proteobacteria,1RTXK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_2749607_3	864051.BurJ1DRAFT_3442	4.349e-162	514.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,1KJ5F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	May be involved in recombination	rdgC	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
HFD2_k127_2749607_14	314264.ROS217_10827	1.717e-58	234.0	2EZUE@1|root,33SYY@2|Bacteria,1NQS7@1224|Proteobacteria,2UQ75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2749607_22	1342302.JASC01000005_gene612	8.531e-07	61.0	2D2G8@1|root,32TCP@2|Bacteria,1N1QA@1224|Proteobacteria,2UD5P@28211|Alphaproteobacteria,3ZUW0@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2749607_0	264198.Reut_B4875	2.715e-248	789.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VJKJ@28216|Betaproteobacteria,1K04G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD2_k127_2749607_18	864051.BurJ1DRAFT_0284	2.876e-25	111.0	COG3133@1|root,COG3133@2|Bacteria,1NDPC@1224|Proteobacteria,2VX7D@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HFD2_k127_2749607_15	1538295.JY96_06130	5.579e-56	198.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2WGT1@28216|Betaproteobacteria,1KPCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_2749607_12	1380394.JADL01000001_gene2398	6.667e-60	216.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,2U0C2@28211|Alphaproteobacteria,2JSP3@204441|Rhodospirillales	204441|Rhodospirillales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HFD2_k127_2749607_16	987059.RBXJA2T_13059	6.592e-40	153.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1KMDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA1	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD2_k127_2749607_10	1216976.AX27061_1233	1.263e-63	240.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,3T48G@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2749607_9	671143.DAMO_0414	1.438e-66	244.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HFD2_k127_2749607_21	1124983.PFLCHA0_c36550	7.35e-13	78.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
HFD2_k127_2749607_2	1123393.KB891327_gene307	2.216e-188	595.0	COG0745@1|root,COG0745@2|Bacteria,1MX29@1224|Proteobacteria,2VJV7@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2749607_6	1123393.KB891327_gene306	2.658e-120	397.0	COG3823@1|root,COG3823@2|Bacteria,1QVEC@1224|Proteobacteria,2WHF6@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD2_k127_2749607_4	399795.CtesDRAFT_PD0875	2.155e-160	517.0	COG0025@1|root,COG0025@2|Bacteria,1QA7B@1224|Proteobacteria,2VHPR@28216|Betaproteobacteria,4ACQT@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD2_k127_2749607_5	887062.HGR_04398	5.173e-149	484.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2VIWG@28216|Betaproteobacteria,4AAVQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HFD2_k127_2749607_7	296591.Bpro_0177	1.392e-119	393.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2VH1V@28216|Betaproteobacteria,4AAQW@80864|Comamonadaceae	28216|Betaproteobacteria	K	Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_2749607_11	399795.CtesDRAFT_PD2171	3.303e-63	230.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,2VRHY@28216|Betaproteobacteria,4AFE9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HFD2_k127_2749607_13	543728.Vapar_5999	1e-59	212.0	29F9U@1|root,3027G@2|Bacteria,1RFT2@1224|Proteobacteria,2VS6S@28216|Betaproteobacteria,4AE04@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2749607_8	748247.AZKH_p0365	3.555e-96	331.0	COG3134@1|root,COG3134@2|Bacteria,1MY27@1224|Proteobacteria,2VMUB@28216|Betaproteobacteria,2KY8P@206389|Rhodocyclales	206389|Rhodocyclales	S	Beta/gamma crystallins	-	-	-	-	-	-	-	-	-	-	-	-	Crystall,Rick_17kDa_Anti
HFD2_k127_2749607_1	1120999.JONM01000001_gene1496	1.184e-206	651.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VKYV@28216|Betaproteobacteria,2KPY2@206351|Neisseriales	206351|Neisseriales	I	Phospholipase D. Active site motifs.	-	-	2.7.8.5	ko:K00995,ko:K06131	ko00564,ko01100,map00564,map01100	-	R01801,R07390	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD2_k127_2749607_19	765912.Thimo_2483	1.283e-17	87.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,1SCQ6@1236|Gammaproteobacteria,1WZ8U@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD2_k127_2749607_17	1158292.JPOE01000002_gene2581	1.305e-37	142.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria,1KNPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HFD2_k127_2764011_5	1265502.KB905931_gene1740	1.479e-119	397.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2VIR0@28216|Betaproteobacteria,4ACI0@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD2_k127_2764011_9	420662.Mpe_A1502	3.766e-76	259.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2VSQB@28216|Betaproteobacteria,1KKSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
HFD2_k127_2764011_0	983917.RGE_23460	6.425e-278	863.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,1KK6P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Sulfite reductase	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HFD2_k127_2764011_4	1265502.KB905931_gene1743	3.876e-120	391.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2VMUD@28216|Betaproteobacteria,4AB2N@80864|Comamonadaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_2764011_3	864051.BurJ1DRAFT_2213	1.81e-128	419.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,1KK0K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_2764011_8	864051.BurJ1DRAFT_2214	4.498e-78	266.0	COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,1KKR1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TIGRFAM phasin family protein	phaP	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HFD2_k127_2764011_2	420662.Mpe_A1507	2.046e-140	455.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VJ0T@28216|Betaproteobacteria,1KITT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_2764011_10	688245.CtCNB1_1416	5.087e-63	222.0	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2VREZ@28216|Betaproteobacteria,4ADX9@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_2764011_6	983917.RGE_23540	2.304e-111	370.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VKIZ@28216|Betaproteobacteria,1KK4H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_2764011_1	420662.Mpe_A1511	3.75e-151	486.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VMN7@28216|Betaproteobacteria,1KKDP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.215,1.1.1.79,1.1.1.81	ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_2764011_7	395495.Lcho_1988	9.433e-110	357.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KJ3Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_279255_6	987059.RBXJA2T_14361	3.886e-56	197.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,1KKI6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_279255_1	395495.Lcho_3436	1.487e-169	536.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,1KJQG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_279255_3	1265502.KB905934_gene3296	5.847e-146	469.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,4A9RD@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_279255_0	864051.BurJ1DRAFT_1084	0.0	1090.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,1KJ66@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD2_k127_279255_5	395495.Lcho_3433	6.677e-107	380.0	COG0664@1|root,COG0664@2|Bacteria,1MUHT@1224|Proteobacteria,2VI43@28216|Betaproteobacteria,1KJG7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_279255_4	414684.RC1_3881	1.387e-135	470.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TYJ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_279255_2	420662.Mpe_A3141	1.675e-150	481.0	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,2VJKN@28216|Betaproteobacteria,1KKAR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
HFD2_k127_2811275_9	864051.BurJ1DRAFT_1159	3.369e-61	219.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,1KJC0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_2811275_2	983917.RGE_08300	6.728e-129	423.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1KIX8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	ABC transporter	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD2_k127_2811275_4	1265502.KB905932_gene1892	1.29e-109	390.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,4AANT@80864|Comamonadaceae	28216|Betaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD2_k127_2811275_0	420662.Mpe_A3232	4.148e-188	608.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1KJG2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HFD2_k127_2811275_11	864051.BurJ1DRAFT_4449	2.236e-34	145.0	COG3017@1|root,COG3017@2|Bacteria,1N2F2@1224|Proteobacteria,2VUJH@28216|Betaproteobacteria,1KM9Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	-	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
HFD2_k127_2811275_3	864051.BurJ1DRAFT_4450	9.839e-128	415.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,1KJR7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_2811275_1	987059.RBXJA2T_15528	2.842e-180	570.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1KJRH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD2_k127_2811275_5	420662.Mpe_A3228	5.777e-94	317.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,1KK92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD2_k127_2811275_6	595537.Varpa_5000	1.742e-93	314.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,4ABYV@80864|Comamonadaceae	28216|Betaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD2_k127_2811275_12	864051.BurJ1DRAFT_4456	0.0001089	54.0	2AET1@1|root,314PZ@2|Bacteria,1PUH0@1224|Proteobacteria,2WAU0@28216|Betaproteobacteria,1KMR4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2811275_10	358220.C380_04860	3.779e-42	156.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,4AEXM@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	fdx1	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HFD2_k127_2811275_7	395495.Lcho_3502	1.674e-87	291.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,1KKNP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_2811275_8	1286631.X805_39760	1.027e-67	237.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,1KKUF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HFD2_k127_2856312_10	395495.Lcho_0415	9.757e-54	190.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,1KKIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	ko:K11690,ko:K21393	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
HFD2_k127_2856312_9	395495.Lcho_0414	2.032e-74	256.0	COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2WFEZ@28216|Betaproteobacteria,1KM15@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
HFD2_k127_2856312_7	1286631.X805_41260	1.286e-92	309.0	COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,2VH3Y@28216|Betaproteobacteria,1KMW6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_9,TetR_N
HFD2_k127_2856312_5	395495.Lcho_3690	8.393e-121	392.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VMTW@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_2856312_4	365044.Pnap_1653	4.389e-130	436.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VMEE@28216|Betaproteobacteria,4AD94@80864|Comamonadaceae	28216|Betaproteobacteria	E	ABC transporter ATP-binding protein	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_2856312_1	395495.Lcho_3688	6.791e-169	544.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VJN3@28216|Betaproteobacteria,1KNT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_2856312_2	296591.Bpro_1849	1.421e-152	488.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VIDW@28216|Betaproteobacteria,4ABK5@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_2856312_0	395495.Lcho_3686	4.984e-188	594.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VHQ4@28216|Betaproteobacteria	28216|Betaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_2856312_6	395495.Lcho_3684	4.367e-109	359.0	COG1414@1|root,COG1414@2|Bacteria,1N957@1224|Proteobacteria,2VN36@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator IclR	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_2856312_8	196490.AUEZ01000022_gene860	2.463e-75	277.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2VF55@28211|Alphaproteobacteria,3K3QA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_2856312_13	296591.Bpro_4210	2.558e-06	56.0	28X66@1|root,2ZJ4K@2|Bacteria,1P70S@1224|Proteobacteria,2W5IG@28216|Betaproteobacteria,4AIRE@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2856312_11	748247.AZKH_3335	2.791e-51	184.0	COG0251@1|root,COG0251@2|Bacteria,1PF0J@1224|Proteobacteria,2W41K@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD2_k127_2856312_12	748247.AZKH_2709	2.287e-41	157.0	COG4101@1|root,COG4101@2|Bacteria,1RIFZ@1224|Proteobacteria	1224|Proteobacteria	G	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_2856312_3	990285.RGCCGE502_05794	1.739e-149	490.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BBD9@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	two-component response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_2873494_15	1121106.JQKB01000036_gene726	0.0004367	49.0	COG0517@1|root,COG0517@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria,2JX0D@204441|Rhodospirillales	204441|Rhodospirillales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HFD2_k127_2873494_5	1123504.JQKD01000025_gene5825	3.031e-119	391.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,2VK62@28216|Betaproteobacteria,4ABA2@80864|Comamonadaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_2873494_12	266265.Bxe_A3278	2.543e-61	215.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VSAQ@28216|Betaproteobacteria,1KGYN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-Demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HFD2_k127_2873494_7	296591.Bpro_0731	1.163e-107	366.0	COG0684@1|root,COG0684@2|Bacteria,1MUWV@1224|Proteobacteria,2VIJI@28216|Betaproteobacteria,4ACBZ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Pfam:Methyltransf_6	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD2_k127_2873494_9	211165.AJLN01000117_gene2962	3.808e-76	263.0	COG3837@1|root,COG3837@2|Bacteria,1G5P0@1117|Cyanobacteria,1JM8D@1189|Stigonemataceae	1117|Cyanobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_2873494_10	1280941.HY2_00115	1.788e-66	243.0	COG0793@1|root,COG0793@2|Bacteria,1R7I0@1224|Proteobacteria,2U0JI@28211|Alphaproteobacteria,43XH0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Peptidase family S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
HFD2_k127_2873494_11	1397528.Q671_02285	6.21e-62	224.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RPTS@1236|Gammaproteobacteria,1XJCD@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD2_k127_2873494_8	987059.RBXJA2T_04698	1.36e-94	324.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VSS9@28216|Betaproteobacteria,1KND5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	xapA	-	2.4.2.1	ko:K03783,ko:K03815	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD2_k127_2873494_13	983917.RGE_45570	2.055e-53	191.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2VX20@28216|Betaproteobacteria	28216|Betaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD2_k127_2873494_4	983917.RGE_45560	1.512e-137	463.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VJY4@28216|Betaproteobacteria,1KKFM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_2873494_1	987059.RBXJA2T_04713	1.316e-157	511.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VHH7@28216|Betaproteobacteria,1KJEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_2873494_0	987059.RBXJA2T_04718	2.598e-224	722.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,1KKHB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_2873494_2	614083.AWQR01000048_gene3240	1.986e-150	482.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2VIQ8@28216|Betaproteobacteria,4AF8G@80864|Comamonadaceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HFD2_k127_2873494_6	987059.RBXJA2T_04728	1.431e-118	410.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HFD2_k127_2873494_3	987059.RBXJA2T_04733	3.032e-146	471.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2VIQ8@28216|Betaproteobacteria,1KPI2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HFD2_k127_2873494_14	983917.RGE_45480	7.855e-23	97.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2W06E@28216|Betaproteobacteria	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_2889580_18	864051.BurJ1DRAFT_0795	1.853e-14	73.0	COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2VQPA@28216|Betaproteobacteria,1KN88@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_2889580_1	748247.AZKH_0529	7.847e-307	949.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_2889580_7	522306.CAP2UW1_0925	4.675e-121	393.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VNVE@28216|Betaproteobacteria,1KR8I@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HFD2_k127_2889580_13	748247.AZKH_0531	1.579e-35	149.0	COG3029@1|root,COG3029@2|Bacteria,1RD34@1224|Proteobacteria,2VTQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Fumarate reductase subunit C	frdC	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Fumarate_red_C
HFD2_k127_2889580_12	1454004.AW11_01462	1.578e-36	148.0	COG3080@1|root,COG3080@2|Bacteria,1RDZD@1224|Proteobacteria,2VTX9@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane	frdD	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Fumarate_red_D
HFD2_k127_2889580_6	983917.RGE_32290	2.744e-171	543.0	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,2VMD3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD2_k127_2889580_0	983917.RGE_32300	0.0	1129.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2VIMW@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HFD2_k127_2889580_19	1267533.KB906734_gene3710	6.467e-14	77.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Phenol_MetA_deg
HFD2_k127_2889580_14	1089545.KB913037_gene2028	1.91e-29	131.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,2GNCH@201174|Actinobacteria,4E9M5@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain of unknown function (DUF4062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,HEAT_2,NACHT
HFD2_k127_2889580_3	365046.Rta_06070	3.844e-233	733.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,4AB0E@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the UPF0061 (SELO) family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HFD2_k127_2889580_17	1437882.AZRU01000211_gene2496	3.47e-20	100.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RXC9@1236|Gammaproteobacteria,1YDU4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
HFD2_k127_2889580_9	864051.BurJ1DRAFT_0691	3.732e-103	339.0	COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,2VQIP@28216|Betaproteobacteria,1KM4D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
HFD2_k127_2889580_10	765911.Thivi_2529	1.993e-44	165.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S9GR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HFD2_k127_2889580_11	765911.Thivi_2528	2.363e-43	160.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,1S7XN@1236|Gammaproteobacteria,1WYP4@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HFD2_k127_2889580_15	420662.Mpe_A2184	2.134e-29	130.0	29SCQ@1|root,32R95@2|Bacteria,1RIT7@1224|Proteobacteria,2VSUG@28216|Betaproteobacteria,1KM4E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2889580_4	748247.AZKH_2178	1.091e-207	655.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VNSM@28216|Betaproteobacteria,2KXTV@206389|Rhodocyclales	206389|Rhodocyclales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_2889580_2	1095769.CAHF01000022_gene326	8.496e-245	785.0	COG1716@1|root,COG1716@2|Bacteria,1PYDB@1224|Proteobacteria,2VNTS@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HFD2_k127_2889580_5	1095769.CAHF01000022_gene327	1.083e-189	638.0	COG0845@1|root,COG0845@2|Bacteria,1MUB0@1224|Proteobacteria,2VPXM@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HFD2_k127_2889580_8	1169143.KB911039_gene4534	6.6e-119	386.0	COG0760@1|root,COG0760@2|Bacteria,1MXJI@1224|Proteobacteria,2VPYI@28216|Betaproteobacteria,1K4AX@119060|Burkholderiaceae	28216|Betaproteobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Rotamase,SurA_N_3
HFD2_k127_2889580_16	398527.Bphyt_4002	1.205e-27	119.0	COG0664@1|root,COG2274@1|root,COG2905@1|root,COG0664@2|Bacteria,COG2274@2|Bacteria,COG2905@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,1K0FE@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding
HFD2_k127_2895687_1	420662.Mpe_A3682	6.912e-114	370.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,1KK6G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Aminotransferase class I and II	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_2895687_4	402626.Rpic_0572	5.242e-50	181.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,2VU18@28216|Betaproteobacteria,1K873@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Domain of unknown function (DUF1924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1924
HFD2_k127_2895687_5	365044.Pnap_1533	1.191e-44	173.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,4AES2@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
HFD2_k127_2895687_3	395495.Lcho_3010	9.767e-90	306.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,1KKSE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD2_k127_2895687_2	365044.Pnap_1535	6.373e-96	329.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,4ADAK@80864|Comamonadaceae	28216|Betaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_2895687_0	338969.Rfer_0504	1.588e-121	410.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,4A9VC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_2925375_5	1123256.KB907941_gene141	4.643e-82	284.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1X2YV@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_2925375_1	983917.RGE_32080	2.284e-276	862.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,1KJV7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_2925375_2	987059.RBXJA2T_10294	3.295e-198	627.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,1KJWA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2925375_3	983917.RGE_32100	1.039e-163	519.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,1KJGJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_2925375_0	987059.RBXJA2T_10284	0.0	1079.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KJH8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_2925375_4	477184.KYC_06856	1.693e-83	286.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2VHAS@28216|Betaproteobacteria,3T1BE@506|Alcaligenaceae	28216|Betaproteobacteria	V	proteins homologs of microcin C7 resistance protein MccF	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HFD2_k127_2925375_7	983917.RGE_32130	2.132e-75	271.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,1KKJF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	Abhydrolase_1,MafB19-deam,TfoX_C
HFD2_k127_2925375_8	1449049.JONW01000009_gene4333	8.422e-37	154.0	COG1514@1|root,COG1514@2|Bacteria,1RI9Z@1224|Proteobacteria,2UD0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	2',5' RNA ligase	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	2_5_RNA_ligase2,LigT_PEase
HFD2_k127_2925375_6	1158292.JPOE01000005_gene181	5.15e-81	276.0	COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2WF01@28216|Betaproteobacteria,1KN1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	FCD	-	-	-	ko:K11475	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_2934695_2	215803.DB30_8307	3.695e-42	164.0	COG2133@1|root,COG2133@2|Bacteria,1PEJE@1224|Proteobacteria,437VF@68525|delta/epsilon subdivisions,2X352@28221|Deltaproteobacteria,2YUAU@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215,GSDH,Ig_3
HFD2_k127_2934695_0	864051.BurJ1DRAFT_1404	5.24e-322	1052.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,1KIV4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD2_k127_2934695_1	987059.RBXJA2T_08088	6.117e-135	444.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,1KK03@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	surface antigen	tama	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HFD2_k127_2938232_1	420662.Mpe_A1880	9.098e-170	548.0	COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,2VKDN@28216|Betaproteobacteria,1KJZ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	TIGRFAM type I secretion outer membrane protein, TolC family	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP,OmpA
HFD2_k127_2938232_2	864051.BurJ1DRAFT_2236	3.67e-87	297.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,1KKQ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HFD2_k127_2938232_0	1538295.JY96_19260	7.502e-178	575.0	COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,2WGPI@28216|Betaproteobacteria,1KPDK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	LapD/MoxY periplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,LapD_MoxY_N
HFD2_k127_2955247_2	864051.BurJ1DRAFT_0179	1.92e-133	427.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KKER@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp2	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HFD2_k127_2955247_1	75379.Tint_0137	2.54e-146	469.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria,1KIVW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Phosphoribulokinase	cbbP	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HFD2_k127_2955247_0	266265.Bxe_B2448	1.474e-271	868.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,1K3HP@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_2955247_4	266264.Rmet_1514	2.396e-79	274.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria,1KDR9@119060|Burkholderiaceae	28216|Betaproteobacteria	G	haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_2955247_3	159087.Daro_3624	5.064e-83	278.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,2KUPU@206389|Rhodocyclales	206389|Rhodocyclales	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HFD2_k127_2956679_9	1504672.669784341	1.976e-45	169.0	COG3162@1|root,COG3162@2|Bacteria,1MZF3@1224|Proteobacteria,2VTZZ@28216|Betaproteobacteria,4AEQT@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HFD2_k127_2956679_5	365044.Pnap_0479	2.954e-85	290.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,4ACDE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_2956679_10	864051.BurJ1DRAFT_4735	4.834e-17	87.0	COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2VXYJ@28216|Betaproteobacteria,1KMVN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1289)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
HFD2_k127_2956679_7	420662.Mpe_A3353	8.765e-71	256.0	COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,2VQJW@28216|Betaproteobacteria,1KKV3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1289,tRNA_edit
HFD2_k127_2956679_2	1265502.KB905932_gene1910	1.353e-157	501.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VIUW@28216|Betaproteobacteria,4AAG8@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Pyruvate carboxyltransferase	hmgcL	GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_2956679_12	1265502.KB905932_gene1911	9.5e-08	59.0	2EGQ8@1|root,33AGE@2|Bacteria,1NMKQ@1224|Proteobacteria,2VYTB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_2956679_11	864051.BurJ1DRAFT_0130	4.052e-08	54.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VIUD@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_2956679_0	864051.BurJ1DRAFT_4738	3.662e-310	963.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1KJWT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	carboxylase	accA1	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HFD2_k127_2956679_6	864051.BurJ1DRAFT_4739	1.35e-80	274.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,2VRVF@28216|Betaproteobacteria,1KKSB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HFD2_k127_2956679_3	864051.BurJ1DRAFT_4740	6.506e-122	403.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,1KJZJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	4.2.1.18	ko:K13766,ko:K15312	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ECH_1
HFD2_k127_2956679_4	864051.BurJ1DRAFT_4741	1.663e-113	373.0	COG0412@1|root,COG0412@2|Bacteria,1PKGT@1224|Proteobacteria,2VINS@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Peptidase_S9
HFD2_k127_2956679_1	365046.Rta_06620	8.897e-192	604.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ7Q@28216|Betaproteobacteria,4AB7G@80864|Comamonadaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_2956679_8	395495.Lcho_2118	6.316e-57	198.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_2959790_3	1265502.KB905929_gene2187	7.844e-128	418.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2VNX9@28216|Betaproteobacteria,4AF61@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_2,PAS_4,PAS_8,PAS_9
HFD2_k127_2959790_5	1265502.KB905929_gene2188	1.198e-71	249.0	COG0745@1|root,COG0745@2|Bacteria,1RJB3@1224|Proteobacteria,2VRB3@28216|Betaproteobacteria	28216|Betaproteobacteria	T	ANTAR	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HFD2_k127_2959790_4	420662.Mpe_A2859	1.185e-109	384.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,1KJC2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HFD2_k127_2959790_1	1265502.KB905929_gene2190	2.9e-305	981.0	COG0642@1|root,COG4251@1|root,COG5002@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,4AJZ3@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_2959790_0	420662.Mpe_A2857	0.0	1156.0	COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KK2Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,Response_reg
HFD2_k127_2959790_2	983917.RGE_17430	1.388e-183	591.0	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,2VK79@28216|Betaproteobacteria,1KIYC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
HFD2_k127_2966064_0	1265502.KB905931_gene1753	9.799e-265	822.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,4ABCV@80864|Comamonadaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
HFD2_k127_2966064_4	420662.Mpe_A1959	1.205e-51	190.0	COG0810@1|root,COG0810@2|Bacteria,1N46T@1224|Proteobacteria,2VV7R@28216|Betaproteobacteria,1KM9I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	-
HFD2_k127_2966064_3	338969.Rfer_2245	5.871e-91	306.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,4AA4Y@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD2_k127_2966064_2	395495.Lcho_1930	7.958e-120	399.0	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,1KJ73@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_2966064_5	365046.Rta_24460	7.976e-40	150.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,4AEG8@80864|Comamonadaceae	28216|Betaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_2966064_1	420662.Mpe_A1955	1.411e-172	552.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,1KJR8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD2_k127_2983970_5	296591.Bpro_0921	8.669e-35	153.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2VP8A@28216|Betaproteobacteria,4AE12@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hyfI	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HFD2_k127_2983970_1	296591.Bpro_0920	1.733e-246	794.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2VJ0R@28216|Betaproteobacteria,4AC30@80864|Comamonadaceae	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HFD2_k127_2983970_0	1366050.N234_08435	4.144e-285	892.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria,1K2R7@119060|Burkholderiaceae	28216|Betaproteobacteria	CP	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HFD2_k127_2983970_3	296591.Bpro_0918	7.712e-109	371.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,4AC7I@80864|Comamonadaceae	28216|Betaproteobacteria	C	hydrogenase 4 membrane	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD2_k127_2983970_2	296591.Bpro_0917	1.54e-174	550.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2VKBD@28216|Betaproteobacteria,4AB8E@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH dehydrogenase	hyfD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HFD2_k127_2983970_4	296591.Bpro_0916	5.296e-83	276.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,4ACA2@80864|Comamonadaceae	28216|Betaproteobacteria	C	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HFD2_k127_299472_1	1286631.X805_27550	6.309e-127	407.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,1KJGE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HFD2_k127_299472_0	983917.RGE_24570	0.0	1187.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1KJ89@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HFD2_k127_299472_2	420662.Mpe_A1882	4.822e-58	208.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,1KM26@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_299472_3	420662.Mpe_A1881	4.783e-50	182.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2VSDF@28216|Betaproteobacteria,1KM47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	regulatory protein, MerR	ycgE	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD2_k127_299472_5	748280.NH8B_1148	1.097e-07	53.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_299472_4	443143.GM18_1836	2.055e-30	125.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_29996_5	1265502.KB905958_gene244	1.223e-120	410.0	COG1018@1|root,COG1018@2|Bacteria,1MU6E@1224|Proteobacteria,2VK6Y@28216|Betaproteobacteria,4AADQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	ko:K03863	ko00627,ko01120,map00627,map01120	-	R05274	RC00392,RC01533	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_29996_7	1245471.PCA10_25830	1.414e-110	368.0	COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1S4Z1@1236|Gammaproteobacteria,1YID4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	1.14.15.23	ko:K22325	-	-	-	-	ko00000,ko01000	-	-	-	Rieske
HFD2_k127_29996_0	640511.BC1002_4176	0.0	1222.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,1K1UZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_29996_8	948106.AWZT01000083_gene2995	2.334e-98	353.0	COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,2VMQ1@28216|Betaproteobacteria,1KHB5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD2_k127_29996_9	1415630.U771_11460	2.808e-98	331.0	COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1S4Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	1.14.15.23	ko:K22325	-	-	-	-	ko00000,ko01000	-	-	-	Rieske
HFD2_k127_29996_10	1232683.ADIMK_2609	1.49e-97	331.0	KOG3460@1|root,32U3Y@2|Bacteria,1N0XV@1224|Proteobacteria,1SPDM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	EthD
HFD2_k127_29996_2	95619.PM1_0221365	9.974e-193	613.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HFD2_k127_29996_4	160488.PP_3200	1.736e-132	442.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RZNZ@1236|Gammaproteobacteria,1YZGB@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
HFD2_k127_29996_11	1114970.PSF113_0823	1.731e-37	158.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,1RYXJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CH	2-polyprenyl-6-methoxyphenol hydroxylase	-	-	1.14.13.182	ko:K17940	ko00405,ko01130,ko02024,ko02025,map00405,map01130,map02024,map02025	-	R10467	RC00236	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD2_k127_29996_6	1232683.ADIMK_2600	9.243e-111	368.0	COG0583@1|root,COG0583@2|Bacteria,1PEF2@1224|Proteobacteria,1RS7V@1236|Gammaproteobacteria,46CUG@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_29996_1	930166.CD58_17500	4.998e-265	823.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_29996_3	1415630.U771_11505	5.009e-181	569.0	COG0329@1|root,COG0329@2|Bacteria,1NUUM@1224|Proteobacteria	1224|Proteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_3007176_0	85643.Tmz1t_1412	5.911e-270	850.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,2KVS8@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_3007176_9	159087.Daro_2709	6.071e-07	61.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2VWCN@28216|Betaproteobacteria,2KXGA@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD2_k127_3007176_7	1304883.KI912532_gene2657	9.467e-43	170.0	COG1247@1|root,COG1247@2|Bacteria,1QVS0@1224|Proteobacteria,2W2KH@28216|Betaproteobacteria,2KZQ4@206389|Rhodocyclales	206389|Rhodocyclales	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3007176_8	338969.Rfer_0172	3.46e-15	88.0	COG2010@1|root,COG2010@2|Bacteria,1PZ21@1224|Proteobacteria,2W347@28216|Betaproteobacteria,4AI4W@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_3007176_6	296591.Bpro_1469	2.165e-62	223.0	COG1426@1|root,COG1917@1|root,COG1426@2|Bacteria,COG1917@2|Bacteria,1RJSH@1224|Proteobacteria	1224|Proteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
HFD2_k127_3007176_3	296591.Bpro_1468	9.873e-163	523.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_3007176_5	1217718.ALOU01000005_gene1481	8.834e-100	338.0	COG3181@1|root,COG3181@2|Bacteria,1MY36@1224|Proteobacteria,2VJK1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3007176_1	296591.Bpro_1465	3.528e-250	785.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VJWK@28216|Betaproteobacteria,4AAJ1@80864|Comamonadaceae	28216|Betaproteobacteria	J	PFAM Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_3007176_4	1123504.JQKD01000008_gene5366	1.864e-162	537.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,4ACMK@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_3007176_2	365046.Rta_18290	6.647e-186	584.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2VJ6S@28216|Betaproteobacteria,4AA2B@80864|Comamonadaceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7,4.4.1.15,4.4.1.25	ko:K01505,ko:K05396,ko:K17950	ko00270,map00270	-	R00997,R01874,R07634	RC00382,RC00419,RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
HFD2_k127_3014476_7	365046.Rta_23970	9.092e-73	246.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,4ADH8@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM molybdopterin biosynthesis MoaE	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HFD2_k127_3014476_6	1157708.KB907451_gene4826	5.936e-94	319.0	COG0789@1|root,COG0789@2|Bacteria,1MWN0@1224|Proteobacteria,2VM4T@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HFD2_k127_3014476_5	760117.JN27_15810	6.797e-98	334.0	COG0477@1|root,COG2814@2|Bacteria,1QUZN@1224|Proteobacteria,2W244@28216|Betaproteobacteria,475JJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3014476_0	983917.RGE_32530	0.0	1452.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,1KJ9T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_3014476_4	864051.BurJ1DRAFT_2508	4.576e-99	340.0	28NZT@1|root,2ZBWJ@2|Bacteria,1RBSK@1224|Proteobacteria,2VQDC@28216|Betaproteobacteria,1KKKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3014476_1	420662.Mpe_A1551	2.116e-306	947.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,1KJXZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_3014476_10	987059.RBXJA2T_18096	7.737e-62	214.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,1KKXS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD2_k127_3014476_12	983917.RGE_27190	8.971e-32	132.0	COG2965@1|root,COG2965@2|Bacteria,1N98W@1224|Proteobacteria,2VVZ4@28216|Betaproteobacteria,1KMH3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Binds single-stranded DNA at the primosome assembly site (PAS)	priB	-	-	ko:K02686	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SSB
HFD2_k127_3014476_11	420662.Mpe_A1528	1.681e-52	185.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,1KM20@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD2_k127_3014476_8	1265502.KB905930_gene1558	1.891e-65	227.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,4ADGP@80864|Comamonadaceae	28216|Betaproteobacteria	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD2_k127_3014476_2	1265502.KB905930_gene1559	1.193e-257	799.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,4A9KD@80864|Comamonadaceae	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD2_k127_3014476_14	1123060.JONP01000020_gene3230	8.232e-09	58.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQ5R@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_3014476_15	1318628.MARLIPOL_16289	6.321e-07	57.0	2F7U0@1|root,34084@2|Bacteria,1NZJ4@1224|Proteobacteria	1318628.MARLIPOL_16289|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3014476_3	296591.Bpro_3376	2.273e-129	422.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2VRMQ@28216|Betaproteobacteria,4AEQZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	nit2	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_3014476_9	1038859.AXAU01000002_gene613	5.655e-64	239.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2U6NS@28211|Alphaproteobacteria,3JZR9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	AHSA1,Putative_PNPOx
HFD2_k127_3014476_13	640511.BC1002_5569	6.911e-27	111.0	2C1W2@1|root,30WYT@2|Bacteria,1PIQW@1224|Proteobacteria,2W7AG@28216|Betaproteobacteria,1KE75@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD2_k127_3014812_10	296591.Bpro_1244	2.909e-46	175.0	COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,4AE03@80864|Comamonadaceae	28216|Betaproteobacteria	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
HFD2_k127_3014812_4	987059.RBXJA2T_00110	1.219e-98	342.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,1KPE4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Methyltransferase domain	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HFD2_k127_3014812_8	1265502.KB905941_gene2889	1.652e-55	214.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,4ADQI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HFD2_k127_3014812_7	864051.BurJ1DRAFT_4217	1.9e-70	253.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,1KKJI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_3014812_0	1286631.X805_19330	1.536e-136	441.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,1KJ5M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HFD2_k127_3014812_6	864051.BurJ1DRAFT_4219	4.22e-73	249.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,1KKTQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HFD2_k127_3014812_11	987059.RBXJA2T_00140	3.864e-40	151.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,1KM9Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HFD2_k127_3014812_9	1265502.KB905941_gene2895	1.235e-49	180.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,4AEDM@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	glpE	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD2_k127_3014812_1	864051.BurJ1DRAFT_4222	7.86e-128	446.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,1KJZT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HFD2_k127_3014812_3	338969.Rfer_2773	1.68e-102	346.0	COG2206@1|root,COG2206@2|Bacteria,1RGJH@1224|Proteobacteria,2VSRC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
HFD2_k127_3014812_5	420662.Mpe_A0710	3.247e-83	287.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VSJD@28216|Betaproteobacteria,1KKMI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD2_k127_3014812_2	420662.Mpe_A0709	1.511e-115	376.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria,1KJM4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Amidohydrolase family	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD2_k127_3017755_3	987059.RBXJA2T_08083	7.541e-74	261.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,1KJD4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD2_k127_3017755_4	1265502.KB905956_gene150	1.927e-41	168.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,4AIZH@80864|Comamonadaceae	28216|Betaproteobacteria	T	diguanylate cyclase	pleD	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
HFD2_k127_3017755_5	216591.BCAM2666	1.931e-30	130.0	COG0671@1|root,COG0671@2|Bacteria,1N0QJ@1224|Proteobacteria,2VVJG@28216|Betaproteobacteria,1K1X7@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_3017755_1	420662.Mpe_A1092	4.518e-91	304.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VKTD@28216|Betaproteobacteria,1KJ0Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_3017755_0	296591.Bpro_1222	2.066e-168	531.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,4A9TQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HFD2_k127_3017755_2	1265502.KB905954_gene417	4.276e-86	292.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,2VU50@28216|Betaproteobacteria,4AAKY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c class I	cytC2	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_3017755_6	1163617.SCD_n01877	2.976e-11	66.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
HFD2_k127_3025016_6	395495.Lcho_2637	7.035e-23	98.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,1KK9B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_3025016_3	397945.Aave_1338	5.564e-72	249.0	COG0500@1|root,COG0500@2|Bacteria,1QU9M@1224|Proteobacteria,2WGK0@28216|Betaproteobacteria,4ADYH@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
HFD2_k127_3025016_0	1265502.KB905936_gene2714	1.009e-149	477.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,4A9Y6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_3025016_1	864051.BurJ1DRAFT_2836	4.515e-134	439.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,1KJ9Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	NlpB/DapX lipoprotein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
HFD2_k127_3025016_2	420662.Mpe_A2565	2.93e-113	370.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_3025016_5	1265502.KB905931_gene1773	1.982e-42	162.0	2AY9T@1|root,31QC7@2|Bacteria,1RK1R@1224|Proteobacteria,2VT1A@28216|Betaproteobacteria,4AECS@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3025016_4	864051.BurJ1DRAFT_2839	2.747e-46	171.0	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,1KJPQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	ycfD	-	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
HFD2_k127_3066419_2	1005395.CSV86_15635	1.173e-50	188.0	COG1960@1|root,COG1960@2|Bacteria,1QMQC@1224|Proteobacteria,1SKN0@1236|Gammaproteobacteria,1YXGG@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_3066419_3	1144319.PMI16_01086	9.38e-26	121.0	COG1846@1|root,COG1846@2|Bacteria,1N7PQ@1224|Proteobacteria,2VTDX@28216|Betaproteobacteria,4783E@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_3066419_1	365044.Pnap_3704	1.703e-80	291.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria,4ADI9@80864|Comamonadaceae	28216|Betaproteobacteria	U	Haemolysin secretion/activation protein ShlB/FhaC/HecB	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
HFD2_k127_3066419_0	1144342.PMI40_02785	7.936e-130	461.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,476AX@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	TIGRFAM filamentous hemagglutinin family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,Glug,Haemagg_act
HFD2_k127_3066419_4	1218076.BAYB01000002_gene304	8.827e-14	83.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,Peptidase_C14,Sel1,TPR_10,TPR_8
HFD2_k127_3066593_0	1265502.KB905952_gene784	1.729e-186	586.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2VJ2K@28216|Betaproteobacteria,4AAEB@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM homocysteine S-methyltransferase	metHa	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HFD2_k127_3066593_1	614083.AWQR01000033_gene2867	2.479e-163	538.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4ACAD@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	gmr	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,MHYT
HFD2_k127_3066593_2	864051.BurJ1DRAFT_0280	7.975e-143	458.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2VK2M@28216|Betaproteobacteria,1KKCB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD2_k127_3069946_9	1157708.KB907453_gene4100	1.37e-140	449.0	COG0240@1|root,COG0240@2|Bacteria,1MXI9@1224|Proteobacteria,2VW0B@28216|Betaproteobacteria,4AJYR@80864|Comamonadaceae	28216|Betaproteobacteria	C	NAD NADP octopine nopaline dehydrogenase	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	ApbA,NAD_Gly3P_dh_N,Octopine_DH
HFD2_k127_3069946_7	595537.Varpa_1642	1.143e-158	513.0	COG1250@1|root,COG1250@2|Bacteria,1MVVD@1224|Proteobacteria,2WEBM@28216|Betaproteobacteria,4AJQZ@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_3069946_11	1157708.KB907453_gene4102	3.501e-109	373.0	COG0596@1|root,COG0596@2|Bacteria,1R6E2@1224|Proteobacteria,2VXT9@28216|Betaproteobacteria,4AJ8I@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_3069946_10	1157708.KB907453_gene4103	8.563e-115	383.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD2_k127_3069946_13	1157708.KB907453_gene4104	3.916e-58	206.0	COG1846@1|root,COG1846@2|Bacteria,1N2K6@1224|Proteobacteria,2VTAJ@28216|Betaproteobacteria,4AEKH@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_3069946_0	365046.Rta_13910	0.0	1239.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,4AASY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_3069946_4	543728.Vapar_1491	1.29e-221	702.0	COG1014@1|root,COG1014@2|Bacteria,1MV7Q@1224|Proteobacteria,2VMSN@28216|Betaproteobacteria,4ABYN@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HFD2_k127_3069946_8	595537.Varpa_1648	8.441e-149	502.0	COG1018@1|root,COG1018@2|Bacteria,1MU6E@1224|Proteobacteria,2VJ0A@28216|Betaproteobacteria,4A9MN@80864|Comamonadaceae	28216|Betaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_3069946_1	62928.azo1983	7.416e-266	822.0	COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VJ0B@28216|Betaproteobacteria,2KWQ2@206389|Rhodocyclales	206389|Rhodocyclales	C	Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation	-	-	1.14.12.10	ko:K05549	ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220	M00551	R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110	RC00270,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_3069946_12	742159.HMPREF0004_1605	4.124e-67	251.0	COG5517@1|root,COG5517@2|Bacteria,1RAVG@1224|Proteobacteria,2VQKZ@28216|Betaproteobacteria,3T3VK@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Ring hydroxylating subunit beta family protein 3	-	-	1.14.12.25	ko:K16303	ko00622,ko01120,ko01220,map00622,map01120,map01220	M00539	R05247	RC00267	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Ring_hydroxyl_B
HFD2_k127_3069946_2	1216976.AX27061_0986	2.483e-259	808.0	COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VJYZ@28216|Betaproteobacteria,3T38M@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_3069946_5	595537.Varpa_1652	3.681e-214	676.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VM79@28216|Betaproteobacteria,4ADCU@80864|Comamonadaceae	28216|Betaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3069946_3	595537.Varpa_1653	7.027e-236	754.0	COG1028@1|root,COG1545@1|root,COG1028@2|Bacteria,COG1545@2|Bacteria,1QVCC@1224|Proteobacteria,2WHP0@28216|Betaproteobacteria,4ABTV@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc,adh_short
HFD2_k127_3069946_6	1157708.KB907453_gene4113	4.872e-161	510.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2VJXW@28216|Betaproteobacteria,4ADDF@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD2_k127_3069946_14	1157708.KB907453_gene4114	1.07e-21	106.0	COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,2VMWV@28216|Betaproteobacteria,4AAXD@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_3106682_5	864051.BurJ1DRAFT_1976	9.625e-20	97.0	2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,2VW65@28216|Betaproteobacteria,1KMGW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pathogenicity locus	mcrB	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	Cdd1
HFD2_k127_3106682_0	983917.RGE_23970	1.971e-115	384.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,1KJT0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD2_k127_3106682_1	365046.Rta_21980	5.187e-105	361.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,4AAGM@80864|Comamonadaceae	28216|Betaproteobacteria	EJ	PFAM Asparaginase glutaminase	ansB	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HFD2_k127_3106682_2	69328.PVLB_06915	2.506e-56	208.0	COG1764@1|root,COG1764@2|Bacteria,1RD1A@1224|Proteobacteria,1S4IY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Organic Hydroperoxide Resistance Protein	ohr	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_3106682_3	420662.Mpe_A0057	1.848e-52	192.0	COG1846@1|root,COG1846@2|Bacteria,1RH1F@1224|Proteobacteria,2VRNB@28216|Betaproteobacteria,1KM1X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
HFD2_k127_3106682_4	420662.Mpe_A1802	4.158e-39	150.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,1KIZX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD2_k127_3120662_10	1265502.KB905929_gene2217	3.724e-54	196.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria,4AHXI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HFD2_k127_3120662_9	640511.BC1002_5497	2.439e-67	261.0	COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,2VMAM@28216|Betaproteobacteria,1K5Q1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_17,TPR_7,TPR_8
HFD2_k127_3120662_3	391038.Bphy_5208	5.841e-112	371.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2VNNN@28216|Betaproteobacteria,1K24Z@119060|Burkholderiaceae	28216|Betaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD2_k127_3120662_0	1157708.KB907461_gene1549	0.0	1119.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2VIAB@28216|Betaproteobacteria,4ABMF@80864|Comamonadaceae	28216|Betaproteobacteria	L	ATP dependent DNA ligase domain protein	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD2_k127_3120662_4	420662.Mpe_A0426	2.009e-101	345.0	COG1192@1|root,COG1192@2|Bacteria,1N4FM@1224|Proteobacteria,2VNTX@28216|Betaproteobacteria,1KKSN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3120662_6	296591.Bpro_2012	1.272e-92	318.0	COG3181@1|root,COG3181@2|Bacteria,1R63S@1224|Proteobacteria,2VMX5@28216|Betaproteobacteria,4A9SG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HFD2_k127_3120662_8	864051.BurJ1DRAFT_2418	5.349e-75	259.0	COG0725@1|root,COG0725@2|Bacteria,1NY9R@1224|Proteobacteria,2VRYF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD2_k127_3120662_1	864051.BurJ1DRAFT_2417	5.625e-150	480.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VPME@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3120662_7	864051.BurJ1DRAFT_2416	1.131e-86	308.0	COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2VRNN@28216|Betaproteobacteria	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_3120662_2	1100720.ALKN01000040_gene2248	4.71e-134	433.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VMWW@28216|Betaproteobacteria,4ABTA@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD2_k127_3120662_5	864051.BurJ1DRAFT_2414	1.171e-98	334.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3125280_1	626418.bglu_2g12410	2.949e-149	484.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2VMGW@28216|Betaproteobacteria,1K1FS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HFD2_k127_3125280_2	420662.Mpe_A0059	1.393e-46	170.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,1KMF8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HFD2_k127_3125280_0	983917.RGE_43890	1.552e-219	695.0	COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIQR@28216|Betaproteobacteria,1KK02@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,TonB_dep_Rec
HFD2_k127_3130342_1	983917.RGE_43340	1.625e-193	614.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,1KJYM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HFD2_k127_3130342_4	338969.Rfer_3780	5.093e-14	75.0	2DS4B@1|root,33EG1@2|Bacteria,1NJ4Q@1224|Proteobacteria,2VYF7@28216|Betaproteobacteria,4AFXF@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3130342_0	395495.Lcho_0236	0.0	1147.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HFD2_k127_3130342_3	1525715.IX54_00880	2.494e-49	183.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2U98H@28211|Alphaproteobacteria,2PX3I@265|Paracoccus	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt,Response_reg
HFD2_k127_3130342_2	983917.RGE_43320	2.109e-141	468.0	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,1KNCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	LT	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_3138231_1	420662.Mpe_A0483	1.004e-132	429.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2VH1P@28216|Betaproteobacteria,1KKB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD2_k127_3138231_5	420662.Mpe_A0482	5.409e-84	283.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2VQ3U@28216|Betaproteobacteria,1KKN3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD2_k127_3138231_0	987059.RBXJA2T_12157	0.0	1078.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1KIW8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	RNB	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HFD2_k127_3138231_2	864051.BurJ1DRAFT_4247	9.854e-130	419.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,1KJAB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HFD2_k127_3138231_3	1538295.JY96_07890	2.132e-109	360.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,1KKDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HFD2_k127_3138231_4	420662.Mpe_A3202	1.414e-102	341.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,1KJAT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HFD2_k127_3138231_6	395495.Lcho_3983	1.252e-79	272.0	2DBKI@1|root,2Z9TC@2|Bacteria,1N3UD@1224|Proteobacteria,2WH5C@28216|Betaproteobacteria,1KPD2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3138231_9	543728.Vapar_0948	1.641e-50	184.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,4ADYS@80864|Comamonadaceae	28216|Betaproteobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_3138231_8	420662.Mpe_A3206	9.437e-62	216.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,1KKUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HFD2_k127_3138231_7	1538295.JY96_07320	5.651e-73	246.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,1KJKR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Biotin carboxylase	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD2_k127_3139299_3	543728.Vapar_1502	2.353e-225	706.0	COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VV59@28216|Betaproteobacteria,4AGJS@80864|Comamonadaceae	28216|Betaproteobacteria	P	dioxygenase, alpha	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_3139299_13	1157708.KB907453_gene4118	3.99e-51	185.0	COG5517@1|root,COG5517@2|Bacteria,1N9BG@1224|Proteobacteria,2VZ1U@28216|Betaproteobacteria,4AHH7@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM aromatic-ring-hydroxylating dioxygenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Ring_hydroxyl_B
HFD2_k127_3139299_4	1157708.KB907453_gene4119	1.765e-199	631.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2W1MI@28216|Betaproteobacteria,4AH4W@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_3139299_5	543728.Vapar_1505	5.326e-161	516.0	COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VPQC@28216|Betaproteobacteria,4AGUR@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_3139299_0	543728.Vapar_1506	1.466e-282	899.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VPN5@28216|Betaproteobacteria,4AIYN@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HFD2_k127_3139299_6	543728.Vapar_1507	6.541e-110	387.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJNG@28216|Betaproteobacteria,4ADN9@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_3139299_2	543728.Vapar_1508	1.787e-247	777.0	COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VHE3@28216|Betaproteobacteria,4ADC5@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_3139299_7	595537.Varpa_1665	7.333e-102	361.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2VM6S@28216|Betaproteobacteria,4AAUB@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	abmB	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.30	ko:K00019,ko:K07535	ko00072,ko00362,ko00650,ko01100,ko01120,ko01220,map00072,map00362,map00650,map01100,map01120,map01220	M00088,M00540	R01361,R05582	RC00117,RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_3139299_11	543728.Vapar_1511	2.3e-69	248.0	COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,2VT2T@28216|Betaproteobacteria,4AE9M@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_3139299_12	543728.Vapar_1512	1.1e-51	194.0	COG0824@1|root,COG0824@2|Bacteria,1MZPN@1224|Proteobacteria,2VTCV@28216|Betaproteobacteria,4AF29@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HFD2_k127_3139299_1	358220.C380_10385	1.525e-279	876.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD2_k127_3139299_9	1157708.KB907450_gene5213	6.907e-89	301.0	COG4291@1|root,COG4291@2|Bacteria,1RGUF@1224|Proteobacteria,2VQ2N@28216|Betaproteobacteria,4ADNG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
HFD2_k127_3139299_8	864051.BurJ1DRAFT_4593	4.253e-93	328.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,1KN2R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_3139299_10	864051.BurJ1DRAFT_4592	4.073e-79	274.0	COG0745@1|root,COG0745@2|Bacteria,1R8UQ@1224|Proteobacteria,2VQE1@28216|Betaproteobacteria,1KMZZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_3153091_1	1265502.KB905944_gene694	7.994e-124	404.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2VHM4@28216|Betaproteobacteria,4AB3D@80864|Comamonadaceae	28216|Betaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HFD2_k127_3153091_5	1448139.AI20_04440	3.56e-32	134.0	COG3832@1|root,COG3832@2|Bacteria,1NKFS@1224|Proteobacteria	1224|Proteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_3153091_0	1265502.KB905944_gene695	8.976e-203	637.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,4AAPD@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	frc_13	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HFD2_k127_3153091_4	76114.ebA2730	5.203e-51	186.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2VRGX@28216|Betaproteobacteria,2KWZ5@206389|Rhodocyclales	206389|Rhodocyclales	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_3153091_6	1123354.AUDR01000015_gene402	3.026e-28	130.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,2WA7N@28216|Betaproteobacteria,1KTDR@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HFD2_k127_3153091_3	864051.BurJ1DRAFT_0120	6.32e-114	373.0	COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,2VIYU@28216|Betaproteobacteria,1KJAU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HFD2_k127_3153091_2	420662.Mpe_A3732	1.731e-117	384.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,1KK6V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Major facilitator superfamily	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
HFD2_k127_3156625_7	365046.Rta_31160	4.271e-30	119.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,4AB70@80864|Comamonadaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD2_k127_3156625_1	365046.Rta_31160	1.073e-171	541.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,4AB70@80864|Comamonadaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD2_k127_3156625_6	1144342.PMI40_04762	2.617e-67	233.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,474CZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	NUDIX domain	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HFD2_k127_3156625_5	864051.BurJ1DRAFT_1307	1.547e-124	404.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,1KJGQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_3156625_4	296591.Bpro_0868	1.807e-126	416.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,4A9Z3@80864|Comamonadaceae	28216|Betaproteobacteria	I	phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD2_k127_3156625_0	543728.Vapar_1003	4.016e-204	642.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,4ABQF@80864|Comamonadaceae	28216|Betaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HFD2_k127_3156625_2	983917.RGE_11060	2.107e-168	538.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2VHKS@28216|Betaproteobacteria,1KKH0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_3156625_3	983917.RGE_11090	1.725e-167	537.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2VJ3Q@28216|Betaproteobacteria,1KK9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA ligase N terminus	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD2_k127_3177996_2	1157708.KB907455_gene3372	3.774e-139	451.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4AD33@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular liganD-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_3177996_5	543728.Vapar_0042	2.748e-90	304.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VI89@28216|Betaproteobacteria,4AB74@80864|Comamonadaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
HFD2_k127_3177996_1	983917.RGE_00470	6.34e-172	556.0	COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,2VPNK@28216|Betaproteobacteria,1KNFX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
HFD2_k127_3177996_3	1100721.ALKO01000027_gene366	9.802e-116	388.0	COG0697@1|root,COG0697@2|Bacteria,1PB22@1224|Proteobacteria,2VYG5@28216|Betaproteobacteria,4AHYC@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3177996_6	864051.BurJ1DRAFT_4481	3.167e-90	310.0	28M4Y@1|root,2ZAIT@2|Bacteria,1R7JR@1224|Proteobacteria,2VM7F@28216|Betaproteobacteria,1KKXQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3177996_7	864051.BurJ1DRAFT_0965	1.754e-18	91.0	2DRFI@1|root,33BHX@2|Bacteria,1NMIT@1224|Proteobacteria,2VY9W@28216|Betaproteobacteria,1KNZD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3177996_4	987059.RBXJA2T_13389	2.438e-102	344.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria,1KK3H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD2_k127_3177996_0	987059.RBXJA2T_13384	5.934e-245	783.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KJIC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_3178884_2	420662.Mpe_A0491	1.505e-165	524.0	COG1028@1|root,COG3320@1|root,COG1028@2|Bacteria,COG3320@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria,1KMYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HFD2_k127_3178884_6	864051.BurJ1DRAFT_1205	6.346e-56	200.0	COG3937@1|root,COG3937@2|Bacteria,1RIXG@1224|Proteobacteria,2VT1J@28216|Betaproteobacteria,1KM36@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Poly(hydroxyalcanoate) granule associated protein (phasin)	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HFD2_k127_3178884_4	420662.Mpe_A0487	1.484e-75	274.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,2VUM5@28216|Betaproteobacteria,1KKMY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SNARE associated Golgi protein	yqaA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_3178884_1	420662.Mpe_A0486	3.328e-166	538.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,1KJF9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HFD2_k127_3178884_7	1265502.KB905949_gene974	2.866e-30	129.0	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,2VVQK@28216|Betaproteobacteria,4AEZK@80864|Comamonadaceae	28216|Betaproteobacteria	KL	Belongs to the transcriptional regulatory Fis family	fis	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
HFD2_k127_3178884_0	1265502.KB905949_gene973	2.948e-275	859.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,4AC6F@80864|Comamonadaceae	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD2_k127_3178884_3	864051.BurJ1DRAFT_1198	6.852e-106	347.0	COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2VQ8G@28216|Betaproteobacteria,1KJA5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HFD2_k127_3178884_5	420662.Mpe_A0483	1.707e-63	227.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2VH1P@28216|Betaproteobacteria,1KKB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD2_k127_3249771_2	864051.BurJ1DRAFT_2480	4.861e-110	362.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,1KKI3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_3249771_4	1265502.KB905935_gene3091	6.363e-74	261.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,4ADK4@80864|Comamonadaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HFD2_k127_3249771_5	1265502.KB905930_gene1575	1.23e-30	129.0	2E4HY@1|root,32ZD1@2|Bacteria,1N74N@1224|Proteobacteria,2VWI1@28216|Betaproteobacteria,4AI9G@80864|Comamonadaceae	28216|Betaproteobacteria	S	Late competence development protein ComFB	-	-	-	-	-	-	-	-	-	-	-	-	ComFB
HFD2_k127_3249771_1	420662.Mpe_A1553	7.176e-131	424.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,1KIX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HFD2_k127_3249771_0	987059.RBXJA2T_19626	2.944e-199	626.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,1KKGD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HFD2_k127_3249771_3	395495.Lcho_2013	1.142e-107	365.0	COG2018@1|root,COG2018@2|Bacteria	2|Bacteria	K	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_3312775_0	1157708.KB907450_gene5252	1.144e-298	927.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,4AAUE@80864|Comamonadaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD4	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_3312775_6	864051.BurJ1DRAFT_1621	2.198e-57	208.0	COG0406@1|root,COG0406@2|Bacteria,1N83T@1224|Proteobacteria,2VY3M@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_3312775_5	535289.Dtpsy_3452	9.194e-59	235.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,2VR0I@28216|Betaproteobacteria,4AFQ2@80864|Comamonadaceae	28216|Betaproteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3312775_3	1265502.KB905972_gene1341	7.304e-84	290.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VR7D@28216|Betaproteobacteria,4AJE8@80864|Comamonadaceae	28216|Betaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3312775_2	1265502.KB905972_gene1340	3.768e-92	317.0	COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,2VR0I@28216|Betaproteobacteria,4AFQ2@80864|Comamonadaceae	28216|Betaproteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3312775_4	1268622.AVS7_02467	2.079e-83	284.0	COG0500@1|root,COG0500@2|Bacteria,1QVCU@1224|Proteobacteria,2VP24@28216|Betaproteobacteria,4AB80@80864|Comamonadaceae	28216|Betaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3312775_1	420662.Mpe_A3082	1.225e-178	570.0	COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2VM8I@28216|Betaproteobacteria,1KKG5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HFD2_k127_3312775_7	983917.RGE_17140	1.682e-31	123.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,1KJQK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_3346632_4	1265502.KB905929_gene2201	1.782e-31	124.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,4AB7Q@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_3346632_3	420662.Mpe_A0549	1.429e-34	137.0	2ETEI@1|root,33KYE@2|Bacteria,1NJKD@1224|Proteobacteria,2W43N@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3346632_5	420662.Mpe_A0596	3.994e-21	100.0	2E56W@1|root,33I8C@2|Bacteria,1NIND@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3346632_2	420662.Mpe_A3347	1.35e-54	202.0	COG0847@1|root,COG0847@2|Bacteria,1RCPS@1224|Proteobacteria,2WEVE@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_3346632_0	1265502.KB905948_gene1003	2.225e-213	680.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae	28216|Betaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HFD2_k127_3346632_1	887062.HGR_04119	4.13e-148	471.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,4AA9Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP_1	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HFD2_k127_3380868_1	983917.RGE_24770	3.036e-197	627.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KK5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_3380868_9	983917.RGE_25030	1.159e-35	142.0	COG2261@1|root,COG2261@2|Bacteria,1N8B3@1224|Proteobacteria,2VWCP@28216|Betaproteobacteria,1KNX3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_3380868_0	397945.Aave_1900	1.127e-228	760.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VIZX@28216|Betaproteobacteria,4AH4S@80864|Comamonadaceae	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_3380868_7	292415.Tbd_0733	1.191e-38	153.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2VT7Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_3380868_5	595537.Varpa_3024	1.102e-58	214.0	COG1376@1|root,COG1376@2|Bacteria,1R7VK@1224|Proteobacteria,2VRX0@28216|Betaproteobacteria,4AE5A@80864|Comamonadaceae	28216|Betaproteobacteria	S	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3380868_2	1366050.N234_24165	5.842e-192	611.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VKWZ@28216|Betaproteobacteria,1K08R@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Dehydrogenase	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD2_k127_3380868_4	983917.RGE_25130	3.833e-88	314.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2VHC0@28216|Betaproteobacteria,1KJE6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AI-2E family transporter	yhhT	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_3380868_8	402626.Rpic_3773	3.454e-36	158.0	COG0671@1|root,COG0671@2|Bacteria,1PFTN@1224|Proteobacteria,2WBYE@28216|Betaproteobacteria,1KDXW@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD2_k127_3380868_6	1095769.CAHF01000006_gene1995	2.269e-55	217.0	COG3233@1|root,COG3233@2|Bacteria,1RG07@1224|Proteobacteria,2VS98@28216|Betaproteobacteria,47759@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HFD2_k127_3380868_3	983917.RGE_24800	1.33e-97	342.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2VHUZ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_3386522_4	987059.RBXJA2T_07363	6.166e-53	197.0	COG4580@1|root,COG4580@2|Bacteria,1MX77@1224|Proteobacteria,2VKXK@28216|Betaproteobacteria,1KNSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Maltoporin (phage lambda and maltose receptor)	lamB	-	-	ko:K02024	-	-	-	-	ko00000,ko02000	1.B.3.1.1	-	-	LamB
HFD2_k127_3386522_1	983917.RGE_02560	2.848e-89	306.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,1KK56@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HFD2_k127_3386522_5	1120973.AQXL01000105_gene2562	8.478e-33	138.0	COG4221@1|root,COG4221@2|Bacteria,1V9C1@1239|Firmicutes,4ISDS@91061|Bacilli	91061|Bacilli	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_3386522_0	983917.RGE_02550	1.661e-208	666.0	COG0837@1|root,COG1737@1|root,COG0837@2|Bacteria,COG1737@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,1KK56@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
HFD2_k127_3386522_2	983917.RGE_02430	2.909e-85	289.0	29SCQ@1|root,30DHC@2|Bacteria,1RGDC@1224|Proteobacteria,2VSB9@28216|Betaproteobacteria,1KKY4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3386522_3	1265502.KB905966_gene1224	2.052e-56	199.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VH8F@28216|Betaproteobacteria,4ACD0@80864|Comamonadaceae	28216|Betaproteobacteria	K	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD2_k127_3407238_0	864051.BurJ1DRAFT_2700	8.358e-211	666.0	COG1073@1|root,COG1073@2|Bacteria,1QTY2@1224|Proteobacteria,2VK86@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Tannase and feruloyl esterase	-	-	3.1.1.102	ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	Tannase
HFD2_k127_3407238_2	1265502.KB905939_gene2401	4.323e-43	162.0	COG1846@1|root,COG1846@2|Bacteria,1N7PQ@1224|Proteobacteria,2VTDX@28216|Betaproteobacteria,4ADXM@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_3407238_1	395495.Lcho_0314	9.272e-202	635.0	COG0807@1|root,COG0807@2|Bacteria,1MWUM@1224|Proteobacteria,2VJRX@28216|Betaproteobacteria,1KJRK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Protein of unknown function (DUF1688)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1688
HFD2_k127_3421491_9	1123073.KB899242_gene1461	1.095e-12	67.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1XA61@135614|Xanthomonadales	135614|Xanthomonadales	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
HFD2_k127_3421491_1	522306.CAP2UW1_2481	1.17e-184	611.0	COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HFD2_k127_3421491_8	95619.PM1_0201790	8.931e-41	168.0	2B3X8@1|root,31WM6@2|Bacteria,1RFUV@1224|Proteobacteria,1RNAH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3999)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3999
HFD2_k127_3421491_7	1265502.KB905952_gene806	6.947e-43	177.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,2VKBX@28216|Betaproteobacteria,4ACSP@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_3421491_10	1219031.BBJR01000034_gene2344	2.317e-09	66.0	COG1704@1|root,COG1704@2|Bacteria,1NB23@1224|Proteobacteria,2VWMF@28216|Betaproteobacteria,4AFDX@80864|Comamonadaceae	28216|Betaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD2_k127_3421491_4	95619.PM1_0202515	3.398e-72	251.0	COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,1S4WX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_3421491_5	983917.RGE_38270	8.89e-49	193.0	COG0640@1|root,COG0640@2|Bacteria,1MWCW@1224|Proteobacteria,2VP44@28216|Betaproteobacteria,1KMA8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HFD2_k127_3421491_2	1538295.JY96_15735	7.768e-117	381.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,1KITI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HFD2_k127_3421491_0	395495.Lcho_4007	3.302e-210	662.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,1KK40@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_3421491_3	1265502.KB905952_gene802	2.426e-109	366.0	COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2VI9B@28216|Betaproteobacteria,4AC5C@80864|Comamonadaceae	28216|Betaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HFD2_k127_3421491_6	864051.BurJ1DRAFT_0218	7.927e-44	178.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,2VMMY@28216|Betaproteobacteria,1KKHK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	frk	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_3423373_7	987059.RBXJA2T_03369	1.007e-54	193.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2VKZJ@28216|Betaproteobacteria,1KJH3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	phosphoserine phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
HFD2_k127_3423373_1	864051.BurJ1DRAFT_2886	2.628e-269	833.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,1KN36@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_3423373_6	365044.Pnap_2372	5.222e-78	265.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2VR2C@28216|Betaproteobacteria,4AE4U@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	rraA	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
HFD2_k127_3423373_5	1123504.JQKD01000029_gene4184	3.982e-78	265.0	COG1522@1|root,COG1522@2|Bacteria,1RI5D@1224|Proteobacteria,2VM6M@28216|Betaproteobacteria,4ADG0@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_3423373_3	1265502.KB905978_gene488	4.104e-138	448.0	COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,2VPGS@28216|Betaproteobacteria,4AAX1@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
HFD2_k127_3423373_0	864051.BurJ1DRAFT_2532	3.232e-299	947.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1KJSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD2_k127_3423373_2	365044.Pnap_2216	7.111e-185	588.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2VHHN@28216|Betaproteobacteria,4AADR@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_3423373_4	395495.Lcho_2013	1.994e-90	309.0	COG2018@1|root,COG2018@2|Bacteria	2|Bacteria	K	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	-
HFD2_k127_3464382_0	420662.Mpe_A2692	2.639e-230	728.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,1KKEE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD2_k127_3464382_5	1265502.KB905929_gene2308	7.117e-80	272.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2VPZP@28216|Betaproteobacteria,4AA91@80864|Comamonadaceae	28216|Betaproteobacteria	P	Iron-storage protein	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_3464382_1	1265502.KB905941_gene2928	8.735e-164	530.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,4AAMX@80864|Comamonadaceae	28216|Betaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD2_k127_3464382_8	497321.C664_02970	7.07e-36	141.0	COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,2VRJ4@28216|Betaproteobacteria,2KX0N@206389|Rhodocyclales	206389|Rhodocyclales	O	Peptidyl-prolyl cis-trans	fkpB	-	5.2.1.8	ko:K03774	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD2_k127_3464382_4	1265502.KB905941_gene2930	2.555e-94	324.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,4ABDV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD2_k127_3464382_6	1265502.KB905941_gene2931	4.676e-74	269.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,4ADI1@80864|Comamonadaceae	28216|Betaproteobacteria	S	Smr protein MutS2	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
HFD2_k127_3464382_3	1123073.KB899242_gene945	4.364e-101	335.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RYRW@1236|Gammaproteobacteria,1X4IY@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_3464382_7	420662.Mpe_A2697	9.66e-57	201.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VSUJ@28216|Betaproteobacteria,1KM1R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial-like globin	yjbI	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_3464382_2	983917.RGE_35400	5.608e-111	364.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2VRTK@28216|Betaproteobacteria,1KIZN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
HFD2_k127_354200_6	381666.H16_A1814	1.832e-91	304.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2VIKT@28216|Betaproteobacteria,1K1GE@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	bdhA	GO:0000003,GO:0000166,GO:0001568,GO:0001676,GO:0001944,GO:0003674,GO:0003824,GO:0004888,GO:0004930,GO:0004953,GO:0004954,GO:0004955,GO:0004957,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007186,GO:0007275,GO:0007276,GO:0007292,GO:0007565,GO:0007567,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009653,GO:0009719,GO:0009987,GO:0010033,GO:0016053,GO:0016404,GO:0016491,GO:0016614,GO:0016616,GO:0019372,GO:0019752,GO:0019953,GO:0022414,GO:0023052,GO:0030728,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0033559,GO:0035239,GO:0035295,GO:0036094,GO:0038023,GO:0042221,GO:0042759,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0045786,GO:0046394,GO:0046456,GO:0046983,GO:0048037,GO:0048514,GO:0048519,GO:0048523,GO:0048609,GO:0048731,GO:0048844,GO:0048856,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051287,GO:0051704,GO:0051716,GO:0051726,GO:0055114,GO:0060089,GO:0060840,GO:0065007,GO:0070013,GO:0070403,GO:0070493,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0072330,GO:0072358,GO:0072359,GO:0097070,GO:0097159,GO:1901265,GO:1901363,GO:1901568,GO:1901570,GO:1901576,GO:2001300,GO:2001301	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_354200_2	381666.H16_A1815	6.592e-172	550.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1K5DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_354200_8	864051.BurJ1DRAFT_0515	2.682e-66	234.0	COG3235@1|root,COG3235@2|Bacteria,1RDMZ@1224|Proteobacteria,2WFSM@28216|Betaproteobacteria,1KKWZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_354200_13	395495.Lcho_2052	1.089e-16	81.0	2EGH0@1|root,33A93@2|Bacteria,1NHBI@1224|Proteobacteria,2VY3R@28216|Betaproteobacteria,1KMU8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3149
HFD2_k127_354200_5	395495.Lcho_3552	5.021e-100	331.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VR0H@28216|Betaproteobacteria,1KN6E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HFD2_k127_354200_10	1458427.BAWN01000007_gene500	4.671e-55	198.0	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2VT55@28216|Betaproteobacteria,4AEYR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD2_k127_354200_1	395495.Lcho_3784	1.844e-260	807.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria,1KK69@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Mo-co oxidoreductase dimerisation domain	soxC	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
HFD2_k127_354200_3	395495.Lcho_3783	1.452e-141	456.0	COG3258@1|root,COG4654@1|root,COG3258@2|Bacteria,COG4654@2|Bacteria,1QTYW@1224|Proteobacteria,2VIQV@28216|Betaproteobacteria,1KJUZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_354200_9	395495.Lcho_3782	2.193e-56	211.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,1KKVX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HFD2_k127_354200_11	1268622.AVS7_01211	7.972e-49	185.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,4AEQV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HFD2_k127_354200_4	420662.Mpe_A2434	2.836e-135	443.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,1KJFD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
HFD2_k127_354200_7	864051.BurJ1DRAFT_3451	4.36e-83	295.0	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,1KMCY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD2_k127_354200_0	864051.BurJ1DRAFT_3353	4.757e-319	988.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1KK3V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	soxB	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
HFD2_k127_354200_12	864051.BurJ1DRAFT_3354	9.467e-48	195.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria,1KMNA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
HFD2_k127_3545417_0	196367.JNFG01000015_gene3814	5.709e-168	531.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VMQJ@28216|Betaproteobacteria,1KGQZ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_3545417_4	67352.JODS01000017_gene2964	0.0001802	55.0	COG0515@1|root,COG4403@1|root,COG0515@2|Bacteria,COG4403@2|Bacteria,2GMRN@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like,Pkinase
HFD2_k127_3545417_2	1121374.KB891576_gene654	1.673e-13	82.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	serine threonine protein phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
HFD2_k127_3545417_3	479435.Kfla_0064	4.232e-06	59.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4DQIX@85009|Propionibacteriales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HFD2_k127_3545417_1	1122243.KB903771_gene1649	7.816e-20	100.0	2CKU6@1|root,33T7R@2|Bacteria,1NTGB@1224|Proteobacteria,1SKKC@1236|Gammaproteobacteria,3NR2Z@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_357182_11	395495.Lcho_0900	4.589e-36	139.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2VU7G@28216|Betaproteobacteria,1KNX6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HFD2_k127_357182_9	1133850.SHJG_3119	1.927e-67	242.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HFD2_k127_357182_3	338969.Rfer_0825	5.668e-180	573.0	COG0277@1|root,COG0277@2|Bacteria,1N4UQ@1224|Proteobacteria,2W1U4@28216|Betaproteobacteria,4AHE1@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HFD2_k127_357182_0	338969.Rfer_0826	8.251e-187	594.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VSBW@28216|Betaproteobacteria,4AGV6@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD2_k127_357182_8	622637.KE124774_gene1697	1.33e-82	285.0	COG3378@1|root,COG3378@2|Bacteria	2|Bacteria	KL	Phage plasmid primase P4 family	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,P22_AR_N,PriCT_1,Prim-Pol
HFD2_k127_357182_14	296591.Bpro_0409	7.096e-17	86.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,2VSGR@28216|Betaproteobacteria	28216|Betaproteobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HFD2_k127_357182_1	1316936.K678_05006	1.738e-183	586.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD2_k127_357182_10	748247.AZKH_2793	1.365e-57	214.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Nicotinamidase	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD2_k127_357182_4	322710.Avin_46230	4.421e-158	512.0	COG1488@1|root,COG1488@2|Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
HFD2_k127_357182_12	556268.OFAG_01368	2.252e-35	141.0	COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,474TC@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_357182_13	472759.Nhal_1647	1.057e-17	91.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HFD2_k127_357182_7	338969.Rfer_0391	1.36e-112	375.0	COG2187@1|root,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria,4AA57@80864|Comamonadaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HFD2_k127_357182_6	338969.Rfer_0392	3.704e-126	413.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,4ABG6@80864|Comamonadaceae	1224|Proteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HFD2_k127_357182_2	595537.Varpa_2594	6.782e-183	586.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,4AAKM@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_357182_5	983917.RGE_11160	1.521e-126	413.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KPHU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_3577923_1	1123393.KB891317_gene2463	4.538e-148	476.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KRKH@119069|Hydrogenophilales	119069|Hydrogenophilales	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
HFD2_k127_3577923_2	420662.Mpe_A2248	2.497e-133	449.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,1KJUV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21344	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HFD2_k127_3577923_0	1538295.JY96_16340	1.176e-157	506.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,1KJJF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
HFD2_k127_3577923_5	1276756.AUEX01000020_gene3410	1.66e-25	108.0	COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,4AEWA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Lipopolysaccharide assembly protein A domain	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
HFD2_k127_3577923_4	864051.BurJ1DRAFT_1777	2.81e-49	183.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,1KM2X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD2_k127_3577923_3	987059.RBXJA2T_16502	8.666e-53	187.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,1KIV0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_3581393_5	395495.Lcho_0542	3.018e-65	225.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VQ4C@28216|Betaproteobacteria,1KK77@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	slmA	-	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
HFD2_k127_3581393_1	864051.BurJ1DRAFT_1216	9.957e-81	278.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2VRFD@28216|Betaproteobacteria,1KKYR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HFD2_k127_3581393_0	987059.RBXJA2T_06895	4.134e-152	484.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,1KJNB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF815)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HFD2_k127_3581393_2	983917.RGE_10350	3.141e-75	254.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,1KKVF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
HFD2_k127_3581393_4	420662.Mpe_A0837	2.031e-69	243.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,1KKTY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HFD2_k127_3581393_7	420662.Mpe_A0838	7.447e-49	177.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,1KM5H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HFD2_k127_3581393_8	420662.Mpe_A0839	8.528e-45	171.0	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,1KM72@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3581393_6	987059.RBXJA2T_06920	1.81e-54	201.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,1KM2P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hitA	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
HFD2_k127_3581393_10	420662.Mpe_A0841	1.338e-30	122.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1KMNQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_3581393_3	420662.Mpe_A0842	1.609e-69	240.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,1KKZA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD2_k127_3581393_9	420662.Mpe_A0843	6.25e-41	158.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,1KJ6N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD2_k127_3582169_6	365044.Pnap_1306	3.18e-09	58.0	2D78S@1|root,32TNJ@2|Bacteria,1N0VB@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4864)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4864
HFD2_k127_3582169_5	983917.RGE_02010	3.078e-64	243.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KKRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Pkinase
HFD2_k127_3582169_4	365044.Pnap_2219	4.296e-67	232.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,2VRJ6@28216|Betaproteobacteria,4ADMN@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM CreA family protein	creA	-	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
HFD2_k127_3582169_2	288000.BBta_0931	1.837e-139	451.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TR3G@28211|Alphaproteobacteria,3JQX6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	MA20_21005	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_3582169_0	1156919.QWC_30696	1.73e-246	764.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2VJR9@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	rspA	-	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_3582169_1	543728.Vapar_2884	3.417e-209	661.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2VIIB@28216|Betaproteobacteria,4AADU@80864|Comamonadaceae	28216|Betaproteobacteria	G	Mannitol dehydrogenase Rossmann domain	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
HFD2_k127_3582169_3	1175306.GWL_09500	1.998e-83	304.0	COG0524@1|root,COG0524@2|Bacteria,1MV6I@1224|Proteobacteria,2VM9T@28216|Betaproteobacteria,475VK@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD2_k127_3610192_2	420662.Mpe_A2128	2.325e-223	694.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,1KK2I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD2_k127_3610192_1	535289.Dtpsy_1658	4.405e-239	750.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,4A9KI@80864|Comamonadaceae	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	1.8.1.4,2.3.1.12	ko:K00382,ko:K00627	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R02569,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_3610192_0	420662.Mpe_A2126	7.825e-311	960.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1KIY6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
HFD2_k127_3611310_5	420662.Mpe_A1898	9.565e-152	482.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,1KITC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_3611310_3	1458275.AZ34_01840	4.306e-194	614.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2VIFN@28216|Betaproteobacteria,4AC96@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD binding domain	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
HFD2_k127_3611310_6	1458275.AZ34_01845	8.241e-121	400.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VQGX@28216|Betaproteobacteria,4ADSX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HFD2_k127_3611310_0	395495.Lcho_1739	6.137e-266	822.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2VJHJ@28216|Betaproteobacteria,1KJKE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	glutamine synthetase	puuA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_3611310_1	887062.HGR_13494	9.647e-254	788.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VHST@28216|Betaproteobacteria,4ABXH@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_3611310_2	420662.Mpe_A1903	2.18e-207	648.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KIYX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_8
HFD2_k127_3611310_4	420662.Mpe_A1904	5.722e-188	593.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,1KJFE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K11076	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	ABC_tran,TOBE_2
HFD2_k127_3611310_7	420662.Mpe_A1905	4.928e-41	170.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KJGM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	transport system permease	potH	-	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
HFD2_k127_3615680_5	452637.Oter_0345	1.91e-120	394.0	COG2382@1|root,COG2382@2|Bacteria,46UMK@74201|Verrucomicrobia,3K8H2@414999|Opitutae	2|Bacteria	P	Belongs to the glycosyl hydrolase 13 family	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	CBM_48,Esterase
HFD2_k127_3615680_0	1121098.HMPREF1534_02233	1.073e-267	853.0	COG3250@1|root,COG3250@2|Bacteria,4NHRH@976|Bacteroidetes,2FR35@200643|Bacteroidia,4APEU@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 2, sugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD2_k127_3615680_8	1349767.GJA_3920	4.076e-59	215.0	COG3279@1|root,COG3279@2|Bacteria,1R9Q4@1224|Proteobacteria,2WEES@28216|Betaproteobacteria,473Y1@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD2_k127_3615680_11	864051.BurJ1DRAFT_0130	1.078e-06	61.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VIUD@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_3615680_9	29581.BW37_05389	4.032e-47	183.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VRIK@28216|Betaproteobacteria,4727E@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HFD2_k127_3615680_10	102129.Lepto7375DRAFT_8056	1.796e-11	74.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185,HTH_18,HTH_AraC
HFD2_k127_3615680_12	931626.Awo_c03910	8.486e-06	56.0	COG2207@1|root,COG2207@2|Bacteria,1TQKE@1239|Firmicutes,24A8P@186801|Clostridia,25VTA@186806|Eubacteriaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,HTH_18
HFD2_k127_3615680_6	1502852.FG94_03796	3.388e-106	364.0	COG1940@1|root,COG1940@2|Bacteria,1NFM0@1224|Proteobacteria,2WG1U@28216|Betaproteobacteria	28216|Betaproteobacteria	GK	PFAM ROK family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
HFD2_k127_3615680_2	159450.NH14_02630	1.128e-197	632.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VI4Z@28216|Betaproteobacteria,1K2VE@119060|Burkholderiaceae	28216|Betaproteobacteria	G	xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_3615680_1	883126.HMPREF9710_04936	9.986e-233	732.0	COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria	1224|Proteobacteria	G	Glycoside Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_35,Glyco_hydro_42
HFD2_k127_3615680_3	794903.OPIT5_19665	2.526e-197	624.0	COG2723@1|root,COG2723@2|Bacteria,46T76@74201|Verrucomicrobia,3K95S@414999|Opitutae	414999|Opitutae	G	Glycosyl hydrolase family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HFD2_k127_3615680_4	452637.Oter_2315	4.974e-140	472.0	COG2211@1|root,COG2211@2|Bacteria,46UFW@74201|Verrucomicrobia	74201|Verrucomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
HFD2_k127_3615680_7	498211.CJA_3007	1.468e-93	327.0	COG3507@1|root,COG3507@2|Bacteria,1MWY2@1224|Proteobacteria,1RR93@1236|Gammaproteobacteria,1FI4J@10|Cellvibrio	1236|Gammaproteobacteria	G	Glycosyl hydrolases family 43	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
HFD2_k127_3620827_6	402626.Rpic_4096	2.19e-96	322.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,1K1PG@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056,ko:K10441	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HFD2_k127_3620827_2	402626.Rpic_4097	6.774e-129	429.0	COG4158@1|root,COG4158@2|Bacteria,1QTYQ@1224|Proteobacteria,2VKCV@28216|Betaproteobacteria,1K1PE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_3620827_3	402626.Rpic_4098	8.774e-112	389.0	COG1172@1|root,COG1172@2|Bacteria,1MW9Z@1224|Proteobacteria,2VIYS@28216|Betaproteobacteria,1K10U@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	yjfF	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_3620827_4	1002340.AFCF01000024_gene1194	3.072e-107	355.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,34ECM@302485|Phaeobacter	28211|Alphaproteobacteria	IQ	KR domain	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_3620827_11	1458275.AZ34_01010	3.297e-08	67.0	2DU0K@1|root,33NF4@2|Bacteria,1NGYY@1224|Proteobacteria,2VYUJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3620827_0	338969.Rfer_0064	5.813e-305	944.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4A9RM@80864|Comamonadaceae	28216|Betaproteobacteria	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HFD2_k127_3620827_9	338969.Rfer_0063	4.06e-26	109.0	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HFD2_k127_3620827_10	1123261.AXDW01000006_gene2449	1.419e-13	78.0	2E4Z6@1|root,32ZSW@2|Bacteria,1N6U2@1224|Proteobacteria,1T8X1@1236|Gammaproteobacteria,1XBCG@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3620827_8	318996.AXAZ01000037_gene1363	8.794e-27	124.0	COG1477@1|root,COG1477@2|Bacteria,1RIPS@1224|Proteobacteria,2V46K@28211|Alphaproteobacteria,3JT81@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD2_k127_3620827_7	1538295.JY96_14070	5.738e-56	202.0	COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria,2VTI7@28216|Betaproteobacteria,1KNRW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HFD2_k127_3620827_1	1538295.JY96_14065	1.576e-152	494.0	COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,2VKY3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
HFD2_k127_3620827_5	1198452.Jab_2c05000	3.245e-104	344.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome C peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD2_k127_3624740_4	395495.Lcho_3909	3.74e-78	263.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1KIXR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HFD2_k127_3624740_6	420662.Mpe_A0014	3.244e-47	174.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,2VSDZ@28216|Betaproteobacteria,1KP5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SURF4 family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD2_k127_3624740_1	983917.RGE_02450	3.202e-201	635.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1KJH9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_3624740_0	864051.BurJ1DRAFT_0296	2.035e-273	855.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,1KJ0G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD2_k127_3624740_3	32042.PstZobell_12661	5.346e-88	303.0	COG0515@1|root,COG0515@2|Bacteria,1R4X3@1224|Proteobacteria,1RSH9@1236|Gammaproteobacteria,1Z0MM@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3624740_7	395493.BegalDRAFT_3487	8.952e-08	63.0	2D1A4@1|root,32TA7@2|Bacteria,1N5RI@1224|Proteobacteria,1SFU2@1236|Gammaproteobacteria,462U8@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3624740_2	1454004.AW11_03034	3.991e-172	554.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2VJUV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD2_k127_3624740_5	1169143.KB911040_gene3074	1.872e-72	248.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1K0QF@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_3626615_4	1286631.X805_08920	6.429e-88	292.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIA6@28216|Betaproteobacteria,1KKA9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD2	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_3626615_6	1038862.KB893840_gene1149	1.548e-65	233.0	COG0596@1|root,COG0596@2|Bacteria,1NZXA@1224|Proteobacteria,2TRDX@28211|Alphaproteobacteria,3JXVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD2_k127_3626615_1	987059.RBXJA2T_01550	1.836e-296	927.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VHTT@28216|Betaproteobacteria,1KKFT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Prolyl oligopeptidase	f1pep1	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_3626615_7	864051.BurJ1DRAFT_3846	4.03e-27	112.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2VW02@28216|Betaproteobacteria,1KMIR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
HFD2_k127_3626615_5	864051.BurJ1DRAFT_3841	9.249e-74	255.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,1KM34@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YaeQ	yaeQ	-	-	-	-	-	-	-	-	-	-	-	YaeQ
HFD2_k127_3626615_2	543728.Vapar_4955	1.028e-173	556.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria,4AAC9@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_3626615_0	987059.RBXJA2T_01565	1.768e-303	944.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VIE8@28216|Betaproteobacteria,1KMZ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HFD2_k127_3626615_3	1265502.KB905943_gene2755	6.046e-143	469.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria,4AJWE@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_7,PAS_8,PAS_9,PilJ,Response_reg
HFD2_k127_3636547_9	864051.BurJ1DRAFT_1159	3.739e-75	254.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,1KJC0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_3636547_10	864051.BurJ1DRAFT_1160	6.128e-63	228.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1KKU2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	MlaD protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD2_k127_3636547_8	1286631.X805_18800	1.621e-76	272.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1KM03@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HFD2_k127_3636547_6	395495.Lcho_3390	6.574e-88	295.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,1KKN9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	toluene tolerance	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD2_k127_3636547_12	420662.Mpe_A3096	1.656e-25	109.0	COG3113@1|root,COG3113@2|Bacteria,1N9WV@1224|Proteobacteria,2VW67@28216|Betaproteobacteria,1KMSY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
HFD2_k127_3636547_5	420662.Mpe_A0437	1.44e-91	312.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1KKD6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HFD2_k127_3636547_1	420662.Mpe_A0436	7.136e-167	529.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,1KJC7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HFD2_k127_3636547_11	864051.BurJ1DRAFT_4398	5.321e-35	136.0	2E4XG@1|root,32ZRD@2|Bacteria,1N79W@1224|Proteobacteria,2VWJP@28216|Betaproteobacteria,1KMGN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	tryptophan synthase subunit beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3636547_4	395495.Lcho_0394	7.859e-93	309.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,1KJQ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_3636547_3	1265502.KB905945_gene634	2.154e-93	316.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,4AAS4@80864|Comamonadaceae	28216|Betaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HFD2_k127_3636547_14	1003200.AXXA_27165	3.1e-05	53.0	COG3157@1|root,COG3157@2|Bacteria,1R3V8@1224|Proteobacteria,2VP81@28216|Betaproteobacteria	28216|Betaproteobacteria	S	type VI secretion system effector, Hcp1 family	hcp1	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD2_k127_3636547_13	381666.H16_A0654	7.101e-08	63.0	COG3157@1|root,COG3157@2|Bacteria,1RC6P@1224|Proteobacteria,2VQKT@28216|Betaproteobacteria,1K6SP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	type VI secretion system effector	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD2_k127_3636547_2	1265502.KB905945_gene633	1.305e-121	396.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2WH63@28216|Betaproteobacteria,4AJVY@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_3636547_0	864051.BurJ1DRAFT_4394	1.272e-272	865.0	COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,1KJVX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HFD2_k127_3636547_7	1265502.KB905945_gene632	4.19e-84	303.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HFD2_k127_3650839_4	1157708.KB907452_gene4002	1.415e-37	143.0	COG1396@1|root,COG1396@2|Bacteria,1Q1NG@1224|Proteobacteria,2VSBV@28216|Betaproteobacteria,4AFB0@80864|Comamonadaceae	28216|Betaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HFD2_k127_3650839_1	864069.MicloDRAFT_00035210	1.036e-66	237.0	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2U9H8@28211|Alphaproteobacteria,1JV5V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	ttr	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD2_k127_3650839_3	420662.Mpe_A3706	1.137e-57	211.0	COG2998@1|root,COG2998@2|Bacteria,1NN3J@1224|Proteobacteria,2VZ0S@28216|Betaproteobacteria,1KP60@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	abc-type tungstate transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3650839_0	1265502.KB905951_gene816	2.428e-78	266.0	COG2258@1|root,COG2258@2|Bacteria,1RAPM@1224|Proteobacteria,2VQFZ@28216|Betaproteobacteria,4AEN5@80864|Comamonadaceae	28216|Betaproteobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HFD2_k127_3650839_2	420662.Mpe_A0662	1.931e-61	218.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,2VR7C@28216|Betaproteobacteria,1KM1Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Lysin motif	ygaU	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
HFD2_k127_3650839_5	983917.RGE_01020	8.549e-28	114.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2VHM4@28216|Betaproteobacteria,1KJEC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HFD2_k127_3713788_1	864051.BurJ1DRAFT_2942	1.021e-279	869.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1KJ8G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD2_k127_3713788_5	987059.RBXJA2T_17986	2.155e-154	502.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,1KJCE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
HFD2_k127_3713788_3	864051.BurJ1DRAFT_2940	2.375e-164	533.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VMR0@28216|Betaproteobacteria,1KNUX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD2_k127_3713788_0	1532557.JL37_00535	1.443e-301	941.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T1N0@506|Alcaligenaceae	28216|Betaproteobacteria	S	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HFD2_k127_3713788_2	864051.BurJ1DRAFT_2937	6.065e-173	554.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,1KIW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_3713788_4	987059.RBXJA2T_17996	4.65e-160	531.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2VJN4@28216|Betaproteobacteria,1KK89@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_3713788_7	983917.RGE_27390	9.093e-133	426.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,1KJMP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD2_k127_3713788_6	987059.RBXJA2T_18006	6.675e-149	477.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,1KJ30@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HFD2_k127_3713788_8	395495.Lcho_2848	1.49e-64	222.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,1KJU7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD2_k127_3726546_1	887062.HGR_01457	1.176e-168	533.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,4AAKI@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HFD2_k127_3726546_5	1265502.KB905930_gene1466	2.085e-08	64.0	COG3197@1|root,COG3197@2|Bacteria,1PUR2@1224|Proteobacteria,2VXMN@28216|Betaproteobacteria,4AG10@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM cytochrome oxidase maturation protein, cbb3-type	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
HFD2_k127_3726546_0	983917.RGE_31950	2.482e-257	813.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,1KJDU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HFD2_k127_3726546_3	1286631.X805_32600	1.729e-55	198.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,1KM2Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD2_k127_3726546_2	614083.AWQR01000031_gene2589	6.458e-114	369.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,4AAFF@80864|Comamonadaceae	28216|Betaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1,3.1.11.6	ko:K03601,ko:K04564	ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD2_k127_3726546_4	420662.Mpe_A2482	2.153e-16	81.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,1KJGW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD2_k127_3736759_5	1123504.JQKD01000002_gene4029	2.636e-88	306.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,4AJ8R@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_3736759_6	296591.Bpro_4690	4.742e-75	258.0	COG4341@1|root,COG4341@2|Bacteria,1N0MY@1224|Proteobacteria,2VRAB@28216|Betaproteobacteria,4ADQP@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM phosphonate degradation operons associated HDIG domain protein	-	-	1.13.11.78	ko:K21196	ko00440,map00440	-	R10722	RC03261	ko00000,ko00001,ko01000	-	-	-	HD
HFD2_k127_3736759_0	864051.BurJ1DRAFT_4436	2.538e-266	829.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2VJWM@28216|Betaproteobacteria,1KKIB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Na+/Pi-cotransporter	nptA	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
HFD2_k127_3736759_1	296591.Bpro_4691	2.608e-244	760.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,4A9PZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_3736759_2	296591.Bpro_4692	2.428e-200	646.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2VM3U@28216|Betaproteobacteria,4ABJX@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
HFD2_k127_3736759_4	296591.Bpro_4693	1.032e-107	355.0	COG1802@1|root,COG1802@2|Bacteria,1MY8X@1224|Proteobacteria,2VRYQ@28216|Betaproteobacteria,4AETD@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_3736759_3	296591.Bpro_4694	2.237e-194	610.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2VKTZ@28216|Betaproteobacteria,4AB2I@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD2_k127_3736759_7	296591.Bpro_4695	3.967e-55	212.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,4ABPI@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	cysA2	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HFD2_k127_3745091_3	420662.Mpe_A1168	3.026e-238	749.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria,1KKFK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Single cache domain 3	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
HFD2_k127_3745091_4	395495.Lcho_3735	7.924e-224	701.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KJH0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD2_k127_3745091_6	987059.RBXJA2T_17464	1.594e-119	392.0	COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2VMWX@28216|Betaproteobacteria,1KJR6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_3745091_2	388051.AUFE01000015_gene5956	2.87e-287	890.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,1K5P1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HFD2_k127_3745091_0	375286.mma_0403	0.0	1546.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,472B9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HFD2_k127_3745091_5	395495.Lcho_1822	9.118e-165	525.0	COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,1KK19@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PBP superfamily domain	-	-	-	ko:K07219	-	-	-	-	ko00000	-	-	-	HTH_1,PBP_like
HFD2_k127_3745091_11	1538295.JY96_20400	1.118e-46	171.0	2ATZM@1|root,31JJE@2|Bacteria,1RIFX@1224|Proteobacteria,2VSS3@28216|Betaproteobacteria,1KM95@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3745091_10	535289.Dtpsy_1914	2.697e-81	293.0	2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
HFD2_k127_3745091_8	864051.BurJ1DRAFT_3979	3.069e-96	323.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria	1224|Proteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3745091_9	864051.BurJ1DRAFT_1333	4.307e-85	289.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,1KKJ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_3745091_7	395495.Lcho_3733	1.382e-97	324.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2VJ39@28216|Betaproteobacteria,1KKHR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Nitrate reductase delta subunit	torD	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HFD2_k127_3745091_1	395495.Lcho_3732	0.0	1057.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,1KJCC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
HFD2_k127_3772641_9	298654.FraEuI1c_4557	3.133e-65	230.0	2DMP1@1|root,32SS8@2|Bacteria,2IMQ1@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0311 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
HFD2_k127_3772641_12	420662.Mpe_A3525	1.626e-20	103.0	2C5P4@1|root,31S8A@2|Bacteria,1QPRA@1224|Proteobacteria,2W9WA@28216|Betaproteobacteria,1KP25@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3772641_2	395495.Lcho_1065	1.432e-148	476.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2VSX2@28216|Betaproteobacteria,1KMKV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_3772641_11	395495.Lcho_3856	8.213e-38	156.0	COG2329@1|root,COG2329@2|Bacteria,1N078@1224|Proteobacteria,2VSX8@28216|Betaproteobacteria,1KPCC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD2_k127_3772641_8	1123504.JQKD01000042_gene4657	5.835e-104	345.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VHGT@28216|Betaproteobacteria,4ACSD@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_3772641_7	1123504.JQKD01000042_gene4658	4.196e-107	352.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKUM@28216|Betaproteobacteria,4ABGV@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_3772641_5	1157708.KB907451_gene4615	2.86e-120	406.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,4AA2K@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_3772641_3	1123504.JQKD01000042_gene4660	3.48e-146	468.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_3772641_1	395495.Lcho_3653	3.7e-172	548.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,1KM2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_3772641_10	1223521.BBJX01000013_gene422	2.763e-44	166.0	COG0589@1|root,COG0589@2|Bacteria,1N674@1224|Proteobacteria,2VTHJ@28216|Betaproteobacteria,4AEMR@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_3772641_0	864051.BurJ1DRAFT_4434	4.946e-178	559.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VJXA@28216|Betaproteobacteria,1KK4P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD2_k127_3772641_4	1265502.KB905939_gene2403	8.393e-121	392.0	COG1024@1|root,COG1024@2|Bacteria,1MWYZ@1224|Proteobacteria,2VJYU@28216|Betaproteobacteria,4AB6X@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.155	ko:K20036	ko00920,map00920	-	R10936	RC00004,RC03306,RC03307	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_3772641_6	864051.BurJ1DRAFT_3926	4.745e-112	369.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,1KJUM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	AMP-binding enzyme	fcs	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
HFD2_k127_3785335_10	987059.RBXJA2T_07055	1.857e-23	116.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria	28216|Betaproteobacteria	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HFD2_k127_3785335_5	420662.Mpe_A2735	6.408e-130	417.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,1KIZW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD2_k127_3785335_9	420662.Mpe_A2736	4.876e-68	236.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,1KM1S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HFD2_k127_3785335_7	543728.Vapar_6138	4.206e-123	402.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2VMB9@28216|Betaproteobacteria,4AB9S@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM intradiol ring-cleavage dioxygenase	-	-	1.13.11.37	ko:K04098	ko00361,ko00362,ko01100,ko01120,map00361,map00362,map01100,map01120	-	R03891,R04061	RC00388,RC01016	ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
HFD2_k127_3785335_2	1157708.KB907457_gene2603	2.964e-166	533.0	COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2WFAR@28216|Betaproteobacteria	1224|Proteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_3785335_4	1157708.KB907457_gene2604	6.665e-143	458.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2WEN9@28216|Betaproteobacteria,4AJR4@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_3785335_8	543728.Vapar_6135	6.511e-104	354.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria	1224|Proteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_3785335_6	1157708.KB907457_gene2606	2.206e-123	399.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2VJQ8@28216|Betaproteobacteria	1224|Proteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_3785335_0	1157708.KB907457_gene2607	3.87e-251	777.0	COG0683@1|root,COG0683@2|Bacteria,1N0MT@1224|Proteobacteria	1224|Proteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6,TAT_signal
HFD2_k127_3785335_3	595537.Varpa_5097	7.677e-144	470.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VM53@28216|Betaproteobacteria,4ACE5@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HFD2_k127_3785335_1	543728.Vapar_6130	6.369e-172	542.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4AB55@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.39,1.2.1.8	ko:K00130,ko:K00146	ko00260,ko00360,ko00643,ko01100,ko01120,map00260,map00360,map00643,map01100,map01120	M00555	R02536,R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_3793310_3	983917.RGE_12460	1.306e-91	302.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,1KIWD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_3793310_5	365046.Rta_28150	1.124e-07	53.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,4AAWB@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_3793310_1	864051.BurJ1DRAFT_2093	8.126e-266	822.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,1KJII@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD2_k127_3793310_4	1265502.KB905929_gene2263	2.129e-22	113.0	COG2938@1|root,COG2938@2|Bacteria,1N2AS@1224|Proteobacteria,2VVYR@28216|Betaproteobacteria,4AFH3@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HFD2_k127_3793310_2	1265502.KB905929_gene2262	1.215e-148	471.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4AB1W@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
HFD2_k127_3793310_0	420662.Mpe_A2168	1.17e-286	883.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD2_k127_3813686_6	1265502.KB905931_gene1770	5.96e-75	265.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,4ADGK@80864|Comamonadaceae	28216|Betaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD2_k127_3813686_1	420662.Mpe_A2571	2.627e-189	606.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,1KJ4Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD2_k127_3813686_2	864051.BurJ1DRAFT_2844	5.702e-164	523.0	COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,2VKGI@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HFD2_k127_3813686_7	614083.AWQR01000028_gene3170	6.5e-45	169.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2VWK8@28216|Betaproteobacteria,4AF4Q@80864|Comamonadaceae	28216|Betaproteobacteria	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_3813686_5	29581.BW37_04691	1.732e-110	377.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,473AH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HFD2_k127_3813686_3	420662.Mpe_A3162	2.666e-133	437.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,1KKRF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD2_k127_3813686_0	420662.Mpe_A3163	5.87e-206	645.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,1KK9H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HFD2_k127_3813686_4	1123504.JQKD01000057_gene3213	4.859e-121	394.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,4A9QR@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HFD2_k127_3838151_0	1205680.CAKO01000038_gene1920	6.485e-97	326.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,2JU60@204441|Rhodospirillales	204441|Rhodospirillales	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_3838151_4	272560.BPSL1130	3.999e-50	188.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2VK3C@28216|Betaproteobacteria,1K098@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3838151_6	272560.BPSL1130	9.872e-17	84.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2VK3C@28216|Betaproteobacteria,1K098@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_3838151_1	859657.RPSI07_3255	1.556e-62	218.0	COG2128@1|root,COG2128@2|Bacteria,1RG5H@1224|Proteobacteria,2VR8S@28216|Betaproteobacteria,1K7V4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_3838151_5	1358423.N180_18650	6.314e-22	109.0	COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1IU8K@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HFD2_k127_3838151_2	883126.HMPREF9710_01266	4.179e-61	233.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VQ5C@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD2_k127_3838151_3	883126.HMPREF9710_01267	4.446e-57	212.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2TM,His_kinase
HFD2_k127_3844918_0	395495.Lcho_4267	7.989e-286	891.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KK3U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_3844918_2	395495.Lcho_4266	2.149e-138	479.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,1KKJ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD2_k127_3844918_4	864051.BurJ1DRAFT_2528	1.07e-84	285.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,1KKM7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HFD2_k127_3844918_1	420662.Mpe_A1614	1.976e-262	814.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,1KK6U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HFD2_k127_3844918_3	365046.Rta_19080	3.337e-112	366.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2VHNW@28216|Betaproteobacteria,4AAB6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Cys Met metabolism pyridoxal-phosphate-dependent	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_3865360_1	543728.Vapar_3077	2.002e-216	681.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,4A9TI@80864|Comamonadaceae	28216|Betaproteobacteria	KQ	GAF modulated sigma54 specific transcriptional regulator, Fis family	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
HFD2_k127_3865360_10	543728.Vapar_3078	1.301e-55	203.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HFD2_k127_3865360_8	983917.RGE_40280	2.574e-90	305.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2VJ22@28216|Betaproteobacteria,1KKHU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Formaldehyde-activating enzyme (Fae)	fae	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
HFD2_k127_3865360_7	543728.Vapar_3080	3.311e-100	343.0	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2VQ7E@28216|Betaproteobacteria	28216|Betaproteobacteria	H	triphosphoribosyl-dephospho-CoA	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HFD2_k127_3865360_3	983917.RGE_40260	9.367e-146	470.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2VJZS@28216|Betaproteobacteria,1KK4S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	rimK	-	-	-	-	-	-	-	-	-	-	-	RimK
HFD2_k127_3865360_2	543728.Vapar_3082	2.567e-148	478.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2VMCD@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
HFD2_k127_3865360_6	543728.Vapar_3083	2.356e-108	365.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,2VQI8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
HFD2_k127_3865360_4	983917.RGE_40230	1.996e-144	463.0	COG1748@1|root,COG1748@2|Bacteria,1QZYP@1224|Proteobacteria,2WHQB@28216|Betaproteobacteria,1KJPC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
HFD2_k127_3865360_5	543728.Vapar_3085	4.085e-113	375.0	COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,2VMEM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Beta-ribofuranosylaminobenzene 5-phosphate synthase	mptG	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD2_k127_3865360_9	983917.RGE_40210	6.971e-67	233.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2VRX8@28216|Betaproteobacteria,1KMDT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD2_k127_3865360_0	420662.Mpe_A2936	1.918e-269	834.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,1KKD7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD2_k127_3873543_9	998674.ATTE01000001_gene3930	1.019e-55	196.0	COG2207@1|root,COG2207@2|Bacteria,1NDY5@1224|Proteobacteria,1RRPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
HFD2_k127_3873543_8	172088.AUGA01000002_gene5973	1.501e-60	233.0	2AI77@1|root,318MJ@2|Bacteria,1MXJB@1224|Proteobacteria,2TW9U@28211|Alphaproteobacteria,3JUTF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3873543_0	319003.Bra1253DRAFT_04419	8.119e-264	819.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,2TQRB@28211|Alphaproteobacteria,3JURQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
HFD2_k127_3873543_1	395495.Lcho_1477	7.871e-204	644.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,1KMWV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c oxidase accessory protein CcoG	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HFD2_k127_3873543_3	296591.Bpro_4727	1.619e-180	573.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,4ACDU@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM NnrS family protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HFD2_k127_3873543_11	1123487.KB892865_gene1505	1.54e-24	121.0	COG3152@1|root,COG3152@2|Bacteria	2|Bacteria	L	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
HFD2_k127_3873543_5	983917.RGE_14460	2.631e-136	436.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,1KJRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD2_k127_3873543_4	395495.Lcho_1725	7.5e-177	563.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,1KN30@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HFD2_k127_3873543_6	395495.Lcho_1726	5.596e-134	433.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,2VJNY@28216|Betaproteobacteria,1KN1C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD2_k127_3873543_2	864051.BurJ1DRAFT_3487	3.959e-197	619.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,1KK9A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HFD2_k127_3873543_7	1122604.JONR01000009_gene2466	7.656e-89	306.0	COG1566@1|root,COG1566@2|Bacteria,1MXZV@1224|Proteobacteria,1S2IJ@1236|Gammaproteobacteria,1X764@135614|Xanthomonadales	135614|Xanthomonadales	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HFD2_k127_3873543_10	1123392.AQWL01000010_gene2283	4.961e-46	186.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,1KSCB@119069|Hydrogenophilales	119069|Hydrogenophilales	G	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD2_k127_3897515_9	987059.RBXJA2T_07643	5.56e-38	143.0	COG4114@1|root,COG4114@2|Bacteria,1QZYT@1224|Proteobacteria,2WHQG@28216|Betaproteobacteria,1KK2K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn
HFD2_k127_3897515_1	983917.RGE_46760	9.131e-210	659.0	COG4114@1|root,COG4114@2|Bacteria,1QZYT@1224|Proteobacteria,2WHQG@28216|Betaproteobacteria,1KK2K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn
HFD2_k127_3897515_4	1286631.X805_00200	1.359e-122	402.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,1KK3K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_3897515_7	395495.Lcho_4099	4.091e-80	274.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VRBJ@28216|Betaproteobacteria,1KKWN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_3897515_10	864051.BurJ1DRAFT_4985	2.987e-36	146.0	COG2197@1|root,COG2197@2|Bacteria,1N324@1224|Proteobacteria,2VUTR@28216|Betaproteobacteria,1KMGG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_3897515_11	1123367.C666_06080	1.28e-21	100.0	COG2863@1|root,COG2863@2|Bacteria,1NGJ1@1224|Proteobacteria,2VVR2@28216|Betaproteobacteria,2KX1J@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD2_k127_3897515_2	987059.RBXJA2T_03663	3.202e-176	570.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,1KIYZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	soxF	-	1.8.2.1,1.8.5.4	ko:K05301,ko:K17218	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528,R10152	RC00168,RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
HFD2_k127_3897515_3	983917.RGE_46730	1.614e-127	434.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,1KJAC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	exodeoxyribonuclease III	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD2_k127_3897515_5	864051.BurJ1DRAFT_4966	5.583e-96	347.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,1KK74@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD2_k127_3897515_8	987059.RBXJA2T_07668	8.662e-73	252.0	28NWD@1|root,2ZBU8@2|Bacteria,1RGNH@1224|Proteobacteria,2VRUN@28216|Betaproteobacteria,1KKWS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HFD2_k127_3897515_0	983917.RGE_46700	1.255e-241	762.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,1KJ6W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD2_k127_3897515_6	864051.BurJ1DRAFT_4962	2.348e-89	295.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1KJ1C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_392157_0	365044.Pnap_1696	4.383e-130	420.0	COG3181@1|root,COG3181@2|Bacteria,1R4FP@1224|Proteobacteria,2VMF5@28216|Betaproteobacteria,4ADU7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_392157_1	864051.BurJ1DRAFT_2520	7.244e-54	196.0	2F27V@1|root,33V61@2|Bacteria,1NVDD@1224|Proteobacteria,2W1VV@28216|Betaproteobacteria,1KNJN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_392157_2	420662.Mpe_A3500	5.226e-49	178.0	COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,2VUPP@28216|Betaproteobacteria,1KMDF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1304)	-	-	-	ko:K08987	-	-	-	-	ko00000	-	-	-	DUF1304
HFD2_k127_3955456_15	864051.BurJ1DRAFT_4844	3.545e-33	131.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haloacid dehalogenase, type II	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HFD2_k127_3955456_18	395963.Bind_1221	4.884e-06	52.0	COG1278@1|root,COG1278@2|Bacteria,1Q55R@1224|Proteobacteria,2UE94@28211|Alphaproteobacteria,3NBPK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HFD2_k127_3955456_19	1388763.O165_023955	1.072e-05	57.0	2EGJ5@1|root,33ABC@2|Bacteria,1NI51@1224|Proteobacteria,1SH35@1236|Gammaproteobacteria,1YVMU@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1161
HFD2_k127_3955456_10	1122603.ATVI01000005_gene3817	1.443e-96	329.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria,1X3MS@135614|Xanthomonadales	135614|Xanthomonadales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD2_k127_3955456_17	420662.Mpe_B0047	5.871e-07	56.0	2EHXM@1|root,33BP4@2|Bacteria,1NGZB@1224|Proteobacteria,2VXZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3606)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3606
HFD2_k127_3955456_11	757424.Hsero_2874	9.972e-92	325.0	COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,2VKYU@28216|Betaproteobacteria,478PQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	TOBE domain	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
HFD2_k127_3955456_3	243233.MCA1380	2.037e-124	419.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1XDT6@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HFD2_k127_3955456_8	395495.Lcho_1357	3.982e-106	347.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,1KJMI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TIGRFAM molybdate ABC transporter	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HFD2_k127_3955456_9	395495.Lcho_1356	3.206e-97	324.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,1KKKB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD2_k127_3955456_0	338969.Rfer_0228	2.306e-278	862.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,4ACAF@80864|Comamonadaceae	28216|Betaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_3955456_5	595537.Varpa_2577	3.04e-109	378.0	COG3181@1|root,COG3181@2|Bacteria,1R4FY@1224|Proteobacteria,2W0CX@28216|Betaproteobacteria,4AH9C@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3955456_6	1286631.X805_24410	4.776e-109	379.0	COG3181@1|root,COG3181@2|Bacteria,1NBZ9@1224|Proteobacteria,2VH6P@28216|Betaproteobacteria,1KNE1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3955456_13	1366050.N234_09415	4.262e-69	248.0	COG3203@1|root,COG3203@2|Bacteria,1NU8T@1224|Proteobacteria,2W1M3@28216|Betaproteobacteria,1KCEQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_3955456_7	296591.Bpro_4324	3.306e-108	358.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2VM81@28216|Betaproteobacteria,4AGC0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD2_k127_3955456_4	614083.AWQR01000028_gene3145	4.336e-116	383.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_3955456_12	1231391.AMZF01000009_gene1777	8.773e-71	259.0	COG0583@1|root,COG0583@2|Bacteria,1Q531@1224|Proteobacteria,2VJXU@28216|Betaproteobacteria,3T8N4@506|Alcaligenaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K16516	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_3955456_14	1500257.JQNM01000003_gene5384	5.029e-51	182.0	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,4BEJV@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_3955456_1	748247.AZKH_4417	2.617e-258	825.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2W8YU@28216|Betaproteobacteria,2KXXB@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
HFD2_k127_3955456_16	326427.Cagg_1060	1.047e-19	98.0	2DRD4@1|root,33B9X@2|Bacteria,2G9Z1@200795|Chloroflexi,377FH@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_3955456_2	1380370.JIBA01000003_gene2760	2.513e-222	707.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4FE2Y@85021|Intrasporangiaceae	201174|Actinobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,PPC,Peptidase_S8
HFD2_k127_4027544_2	420662.Mpe_A0017	2.824e-59	215.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VTUB@28216|Betaproteobacteria,1KMHV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4027544_5	296591.Bpro_0893	3.765e-06	60.0	COG5393@1|root,COG5393@2|Bacteria,1NDFU@1224|Proteobacteria,2VX3I@28216|Betaproteobacteria,4AFUV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD2_k127_4027544_3	395494.Galf_2212	3.941e-11	67.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,44WIE@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HFD2_k127_4027544_4	1496688.ER33_10310	1.597e-09	67.0	COG0412@1|root,COG0412@2|Bacteria,1G1CY@1117|Cyanobacteria	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD2_k127_4027544_0	1122604.JONR01000009_gene2307	3.995e-188	593.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1X358@135614|Xanthomonadales	135614|Xanthomonadales	CE	Catalyzes the formation of 2-oxoglutarate from isocitrate	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_4027544_1	983917.RGE_20380	3.49e-155	502.0	COG0457@1|root,COG0457@2|Bacteria,1NR0V@1224|Proteobacteria,2VZBN@28216|Betaproteobacteria,1KMZN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_403130_9	1121861.KB899919_gene2786	2.293e-35	140.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JUZE@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD2_k127_403130_5	395495.Lcho_2991	4.822e-134	468.0	2EFKN@1|root,339CX@2|Bacteria,1N8ST@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_403130_0	395495.Lcho_2991	9.116e-208	659.0	2EFKN@1|root,339CX@2|Bacteria,1N8ST@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_403130_2	1123257.AUFV01000005_gene1307	1.237e-162	517.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,1RQ2R@1236|Gammaproteobacteria,1X41X@135614|Xanthomonadales	135614|Xanthomonadales	M	3-beta hydroxysteroid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_403130_6	1123257.AUFV01000005_gene1301	5.37e-115	402.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria,1X353@135614|Xanthomonadales	135614|Xanthomonadales	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
HFD2_k127_403130_3	1123257.AUFV01000005_gene1302	1.383e-151	511.0	2C4HX@1|root,2Z9XP@2|Bacteria,1MY22@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_403130_4	1123257.AUFV01000005_gene1303	2.971e-149	491.0	COG1262@1|root,COG1262@2|Bacteria,1R59H@1224|Proteobacteria	1224|Proteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HFD2_k127_403130_7	1123256.KB907931_gene2751	8.702e-82	282.0	2DBS0@1|root,2ZANT@2|Bacteria,1R8Y3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_403130_8	404589.Anae109_3662	6.381e-65	226.0	COG3832@1|root,COG3832@2|Bacteria,1RJ9N@1224|Proteobacteria,431P8@68525|delta/epsilon subdivisions,2WWA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_403130_1	983917.RGE_08500	1.032e-178	570.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VIJ1@28216|Betaproteobacteria,1KKIM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_4055034_1	1118235.CAJH01000023_gene1661	2.187e-106	379.0	COG0457@1|root,COG0515@1|root,COG3063@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3063@2|Bacteria,1MVEU@1224|Proteobacteria,1S0IU@1236|Gammaproteobacteria,1X52Q@135614|Xanthomonadales	135614|Xanthomonadales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12,TPR_8
HFD2_k127_4055034_4	1538295.JY96_11890	1.56e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,1N3BR@1224|Proteobacteria,2VV6Y@28216|Betaproteobacteria,1KM9X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HFD2_k127_4055034_0	1380394.JADL01000012_gene1057	3.188e-169	548.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2JVMP@204441|Rhodospirillales	204441|Rhodospirillales	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_4055034_2	640081.Dsui_3229	7.284e-88	300.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KUAT@206389|Rhodocyclales	206389|Rhodocyclales	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HFD2_k127_4055034_3	1000565.METUNv1_01859	1.577e-59	214.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales	206389|Rhodocyclales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
HFD2_k127_407270_2	1500894.JQNN01000001_gene3133	6.13e-231	728.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2VJ1D@28216|Betaproteobacteria,4724C@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	bglX	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HFD2_k127_407270_1	401053.AciPR4_2656	8.648e-276	896.0	COG3669@1|root,COG3669@2|Bacteria,3Y37T@57723|Acidobacteria,2JKVF@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,F5_F8_type_C
HFD2_k127_407270_0	1198452.Jab_2c25550	0.0	1101.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2WAKQ@28216|Betaproteobacteria,477CY@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Domain of unknown function (DUF4982)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HFD2_k127_4075097_3	864051.BurJ1DRAFT_2945	2.917e-105	343.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,1KJ42@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD2_k127_4075097_1	420662.Mpe_A1986	7.009e-170	549.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1KKAN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HFD2_k127_4075097_4	420662.Mpe_A1987	2.011e-19	89.0	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria,1KMRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HFD2_k127_4075097_2	983917.RGE_27480	7.876e-150	481.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,1KJ28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HFD2_k127_4075097_0	987059.RBXJA2T_17951	4.46e-175	559.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,1KJG9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
HFD2_k127_4075097_5	420662.Mpe_A1990	0.0005538	45.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,1KJBX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD2_k127_4088888_3	395495.Lcho_3710	4.339e-42	175.0	COG3409@1|root,COG3409@2|Bacteria,1N4WW@1224|Proteobacteria,2VH9D@28216|Betaproteobacteria,1KJ52@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,PG_binding_1
HFD2_k127_4088888_4	420324.KI911952_gene3300	1.194e-21	108.0	COG0457@1|root,COG0457@2|Bacteria,1N6TJ@1224|Proteobacteria,2UG5W@28211|Alphaproteobacteria,1JYPC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HFD2_k127_4088888_2	420662.Mpe_A3093	1.138e-61	220.0	COG1011@1|root,COG1011@2|Bacteria,1Q69Z@1224|Proteobacteria,2VQKJ@28216|Betaproteobacteria,1KM50@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_4088888_0	1265502.KB905939_gene2393	1.675e-287	906.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,4AAGQ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD2_k127_4088888_1	1286631.X805_18860	9.332e-157	501.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,1KJG4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_4095047_1	420662.Mpe_A0003	1.997e-123	398.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1KJTT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD2_k127_4095047_2	1265502.KB905952_gene791	1.754e-118	410.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,4AADJ@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139,ko:K18903	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00698,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,1.B.17.3.3,2.A.6.2	-	-	OEP
HFD2_k127_4095047_0	864051.BurJ1DRAFT_4556	0.0	1507.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ2M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	AcrB/AcrD/AcrF family	acrD	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_4095047_3	1265502.KB905952_gene789	3.916e-117	393.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,4AAYK@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585,ko:K18145	ko01501,ko01503,map01501,map01503	M00646,M00647,M00649,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,2.A.6.2.40,8.A.1,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_4095047_4	1116472.MGMO_66c00500	2.186e-09	63.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,1T670@1236|Gammaproteobacteria,1XGE6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
HFD2_k127_4098584_1	1265502.KB905961_gene350	8.523e-139	458.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,4A9VK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HFD2_k127_4098584_0	987059.RBXJA2T_00754	0.0	1463.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1KJT4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD2_k127_4098584_2	1458275.AZ34_09560	1.977e-72	259.0	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,4AC93@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4103412_1	1177154.Y5S_01713	1.922e-128	423.0	COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales	135619|Oceanospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD2_k127_4103412_7	1177154.Y5S_01712	1.422e-37	161.0	COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103412_10	1177154.Y5S_01711	1.686e-19	93.0	2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4103412_6	1177154.Y5S_01710	1.085e-53	196.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,1XJSI@135619|Oceanospirillales	135619|Oceanospirillales	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HFD2_k127_4103412_8	1177154.Y5S_01709	4.396e-37	145.0	COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,1XQ15@135619|Oceanospirillales	135619|Oceanospirillales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HFD2_k127_4103412_9	1279017.AQYJ01000026_gene60	3.935e-25	111.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	biopolymer transport protein	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HFD2_k127_4103412_4	1177154.Y5S_01707	3.093e-77	278.0	COG0810@1|root,COG0810@2|Bacteria,1RJ7J@1224|Proteobacteria,1S817@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HFD2_k127_4103412_0	420662.Mpe_A2999	6.556e-157	505.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,1KIVT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	HemY protein N-terminus	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_12
HFD2_k127_4103412_3	987059.RBXJA2T_17569	1.403e-105	359.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,1KJM7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	HemX, putative uroporphyrinogen-III C-methyltransferase	hemX	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,HemX
HFD2_k127_4103412_5	420662.Mpe_A3001	3.715e-72	254.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,1KKSG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HFD2_k127_4103412_2	864051.BurJ1DRAFT_1371	2.294e-128	415.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,1KK8R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD2_k127_4120961_1	543728.Vapar_0857	4.168e-66	248.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VJXE@28216|Betaproteobacteria,4AB6I@80864|Comamonadaceae	28216|Betaproteobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HFD2_k127_4120961_0	864051.BurJ1DRAFT_0877	2.738e-188	591.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1KJF0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD2_k127_4120961_3	365044.Pnap_1111	4.939e-33	145.0	COG3631@1|root,COG3631@2|Bacteria,1RI6F@1224|Proteobacteria,2WEA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HFD2_k127_4120961_2	395495.Lcho_4061	1.74e-49	181.0	COG0346@1|root,COG0346@2|Bacteria,1RABQ@1224|Proteobacteria,2VS4J@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_4131768_5	983917.RGE_02680	3.978e-76	276.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,DUF3372,PUD
HFD2_k127_4131768_11	983917.RGE_02680	2.872e-23	109.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,DUF3372,PUD
HFD2_k127_4131768_4	395495.Lcho_0068	7.831e-79	281.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VRRI@28216|Betaproteobacteria,1KNI7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	iorA2	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_4131768_7	438753.AZC_3274	1.403e-49	204.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3EYE0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_4131768_0	395495.Lcho_0067	5.648e-296	915.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KNAW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_4131768_10	395495.Lcho_0066	1.555e-34	154.0	COG2010@1|root,COG2010@2|Bacteria,1RIV2@1224|Proteobacteria,2VUIV@28216|Betaproteobacteria,1KNW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD2_k127_4131768_8	395495.Lcho_0065	1.413e-49	180.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2WFPD@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HFD2_k127_4131768_9	395495.Lcho_0064	1.799e-35	145.0	COG5501@1|root,COG5501@2|Bacteria,1N03V@1224|Proteobacteria,2VT2P@28216|Betaproteobacteria,1KMUQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur oxidation protein SoxZ	-	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HFD2_k127_4131768_3	1297570.MESS4_610036	7.364e-93	317.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2TTDW@28211|Alphaproteobacteria,43IAF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	C-type diheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c that then channels them into the respiratory electron transport chain. Some electrons may be used for reductive CO(2) fixation	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
HFD2_k127_4131768_1	864051.BurJ1DRAFT_4157	1.084e-232	726.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,1KJVF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD2_k127_4131768_2	983917.RGE_20370	3.461e-185	606.0	COG1572@1|root,COG1572@2|Bacteria,1NR2F@1224|Proteobacteria,2VZSX@28216|Betaproteobacteria,1KNGJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
HFD2_k127_4131768_6	983917.RGE_20380	6.429e-51	190.0	COG0457@1|root,COG0457@2|Bacteria,1NR0V@1224|Proteobacteria,2VZBN@28216|Betaproteobacteria,1KMZN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4135413_2	420662.Mpe_A2185	3.479e-130	421.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,1KJ8T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_4135413_0	1095769.CAHF01000022_gene253	0.0	1013.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_4135413_1	1286631.X805_23280	1.709e-134	430.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,1KKIR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Domain of unknown function (DUF3362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HFD2_k127_4153894_7	1265502.KB905962_gene356	2.173e-46	171.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,4A9ZR@80864|Comamonadaceae	28216|Betaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD2_k127_4153894_3	983917.RGE_45300	3.725e-150	486.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,1KJ74@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
HFD2_k127_4153894_0	987059.RBXJA2T_02907	6.857e-286	902.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KJYE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
HFD2_k127_4153894_4	987059.RBXJA2T_02912	2.198e-144	466.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,1KJBW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HFD2_k127_4153894_6	159087.Daro_0536	1.404e-47	174.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,2KWTZ@206389|Rhodocyclales	206389|Rhodocyclales	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HFD2_k127_4153894_2	1286631.X805_08820	4.321e-179	569.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,1KJUS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD2_k127_4153894_1	420662.Mpe_A3563	2.342e-223	698.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,1KJ7R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4153894_5	420662.Mpe_A3564	5.3e-100	365.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KK13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_4153894_8	1265502.KB905955_gene474	3.871e-12	68.0	COG0745@1|root,COG0745@2|Bacteria,1N2T7@1224|Proteobacteria,2VSUA@28216|Betaproteobacteria,4AIKH@80864|Comamonadaceae	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_4169691_5	1276756.AUEX01000020_gene3383	9.016e-63	218.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,4ABCV@80864|Comamonadaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
HFD2_k127_4169691_1	864051.BurJ1DRAFT_2308	1.324e-128	422.0	COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,1KJGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
HFD2_k127_4169691_3	987059.RBXJA2T_00445	1.387e-94	337.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,1KJ5K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD2_k127_4169691_4	983917.RGE_16190	1.037e-91	312.0	2BUI6@1|root,32PUF@2|Bacteria,1PJFC@1224|Proteobacteria,2VSBG@28216|Betaproteobacteria,1KMUS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3445)	-	-	1.14.13.238	ko:K22342	-	-	-	-	ko00000,ko01000	-	-	-	DUF3445
HFD2_k127_4169691_0	1265502.KB905931_gene1750	4.793e-190	614.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,4AA02@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	-	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
HFD2_k127_4169691_7	1123504.JQKD01000031_gene4575	1.116e-06	53.0	2EGJB@1|root,33ABH@2|Bacteria,1NI1G@1224|Proteobacteria,2VXT5@28216|Betaproteobacteria,4AFVV@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4169691_2	1265502.KB905931_gene1722	4.243e-108	355.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,4AC1S@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HFD2_k127_4169691_6	1286631.X805_10850	1.231e-08	59.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1KK3B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD2_k127_4215187_6	1157708.KB907458_gene1779	9.671e-82	278.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,4A9Z2@80864|Comamonadaceae	28216|Betaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
HFD2_k127_4215187_5	1286631.X805_11270	5.17e-86	290.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,1KIX3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
HFD2_k127_4215187_3	395495.Lcho_0585	2.474e-119	398.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VH2U@28216|Betaproteobacteria,1KJRE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HFD2_k127_4215187_8	1357275.AVEL02000087_gene935	8.406e-26	108.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,1S80Z@1236|Gammaproteobacteria,1Z6YE@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_4215187_1	987059.RBXJA2T_07958	5.687e-145	473.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,1KKE2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	OU	peptidase S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD2_k127_4215187_7	1286631.X805_15250	2.547e-44	167.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,1KMA9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD2_k127_4215187_4	1265502.KB905932_gene1818	3.221e-93	321.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,4ABA7@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	ppaX	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD2_k127_4215187_2	1265502.KB905932_gene1819	1.781e-133	461.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,4AA5K@80864|Comamonadaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_4215187_0	420662.Mpe_A0656	4.988e-266	823.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,1KJ6P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD2_k127_4247800_1	864051.BurJ1DRAFT_0737	3.455e-140	451.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2VHMJ@28216|Betaproteobacteria,1KK2S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HFD2_k127_4247800_5	1538295.JY96_06595	2.031e-64	229.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria,1KKZU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Response regulator receiver	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD2_k127_4247800_3	420662.Mpe_A2875	1.211e-99	331.0	COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,2VN5G@28216|Betaproteobacteria,1KKA6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NT	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)	cheZ	-	-	ko:K03414	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheZ
HFD2_k127_4247800_8	338966.Ppro_0402	9.179e-08	63.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HFD2_k127_4247800_6	640511.BC1002_5538	2.719e-50	197.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HFD2_k127_4247800_0	420662.Mpe_A0040	1.606e-155	509.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HFD2_k127_4247800_7	443143.GM18_2200	1.674e-18	101.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,43VBT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
HFD2_k127_4247800_2	864051.BurJ1DRAFT_4071	6.877e-138	449.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2VIH0@28216|Betaproteobacteria,1KIWM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
HFD2_k127_4247800_4	420662.Mpe_A3078	1.947e-91	307.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,1KJHC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
HFD2_k127_4278113_0	864051.BurJ1DRAFT_0243	0.0	1102.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,1KJAJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_4278113_7	420662.Mpe_A0258	1.052e-41	162.0	COG1586@1|root,COG1586@2|Bacteria,1QWFT@1224|Proteobacteria,2VTEG@28216|Betaproteobacteria,1KMJU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
HFD2_k127_4278113_6	864051.BurJ1DRAFT_0241	1.671e-84	293.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,1KKK8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	JM	Nucleotidyl transferase	rmlA	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HFD2_k127_4278113_9	1265502.KB905952_gene794	4.3e-10	71.0	2BX29@1|root,331BX@2|Bacteria,1NCJ1@1224|Proteobacteria,2VXBK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4278113_3	420662.Mpe_A0254	1.341e-190	619.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VIVH@28216|Betaproteobacteria,1KJKC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HFD2_k127_4278113_4	420662.Mpe_A0250	2.932e-180	584.0	COG1232@1|root,COG1232@2|Bacteria,1QX5M@1224|Proteobacteria,2WHD4@28216|Betaproteobacteria,1KK6Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_4278113_1	864051.BurJ1DRAFT_0202	5.536e-249	777.0	COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,1KJ98@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HFD2_k127_4278113_8	420662.Mpe_A0248	2.746e-27	115.0	2EGTE@1|root,33AJI@2|Bacteria,1N5DW@1224|Proteobacteria,2VUCZ@28216|Betaproteobacteria,1KMN4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
HFD2_k127_4278113_2	420662.Mpe_A0247	1.93e-204	649.0	COG1379@1|root,COG1379@2|Bacteria,1MVED@1224|Proteobacteria,2VJM0@28216|Betaproteobacteria,1KJW4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
HFD2_k127_4278113_5	420662.Mpe_A0246	3.254e-128	413.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,1KJEH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,HTH_17,SHOCT
HFD2_k127_42824_8	94624.Bpet4483	1.496e-112	373.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,2VH6E@28216|Betaproteobacteria,3T22F@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_42824_11	365044.Pnap_3439	3.251e-80	274.0	COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,2VIHS@28216|Betaproteobacteria,4ABKW@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	entA	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_42824_4	595537.Varpa_1806	7.325e-156	499.0	COG3181@1|root,COG3181@2|Bacteria,1MXC0@1224|Proteobacteria,2VKN6@28216|Betaproteobacteria,4A9T4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_42824_3	543728.Vapar_5676	3.941e-161	529.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2VH30@28216|Betaproteobacteria,4AD2X@80864|Comamonadaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_42824_7	94624.Bpet4484	2.311e-131	426.0	COG0583@1|root,COG0583@2|Bacteria,1R4QT@1224|Proteobacteria,2WG6V@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	ko:K21645	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_42824_6	864051.BurJ1DRAFT_4904	2.141e-132	428.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,1KJCS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	PBP superfamily domain	tupB	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HFD2_k127_42824_1	1157708.KB907450_gene5138	1.301e-178	568.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,4ADNV@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_42824_0	296591.Bpro_1509	1.637e-184	589.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,4AJ6S@80864|Comamonadaceae	28216|Betaproteobacteria	C	Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_42824_14	365044.Pnap_0054	6.534e-17	92.0	2EMQY@1|root,33FDF@2|Bacteria,1NPR7@1224|Proteobacteria,2VYZM@28216|Betaproteobacteria,4AIQD@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_42824_2	1198452.Jab_2c30170	6.101e-178	573.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,2VNV5@28216|Betaproteobacteria,475N7@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Substrate binding domain of ABC-type glycine betaine transport system	opuBC	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HFD2_k127_42824_10	1265502.KB905932_gene1916	2.023e-100	330.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,4AJTE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
HFD2_k127_42824_12	1265502.KB905932_gene1915	9.661e-59	208.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2VRMK@28216|Betaproteobacteria,4AEPK@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD2_k127_42824_13	1054213.HMPREF9946_02315	1.994e-48	181.0	COG2318@1|root,COG2318@2|Bacteria,1R974@1224|Proteobacteria,2U4ZA@28211|Alphaproteobacteria,2JWDS@204441|Rhodospirillales	204441|Rhodospirillales	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HFD2_k127_42824_5	543728.Vapar_4725	8.894e-142	457.0	COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,2VISE@28216|Betaproteobacteria,4ABDZ@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HFD2_k127_42824_9	395495.Lcho_2118	1.025e-106	349.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KJ65@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_4316784_3	420662.Mpe_A2747	1.89e-28	117.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,1KJN6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HFD2_k127_4316784_1	864051.BurJ1DRAFT_1760	2.531e-212	665.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,1KIT6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HFD2_k127_4316784_2	1265502.KB905943_gene2783	5.913e-117	384.0	COG4255@1|root,COG4255@2|Bacteria,1R59K@1224|Proteobacteria,2VKW9@28216|Betaproteobacteria,4AATX@80864|Comamonadaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PhosphMutase
HFD2_k127_4316784_0	1265502.KB905943_gene2782	3.234e-273	863.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,4ABP4@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HFD2_k127_4408591_6	395495.Lcho_1542	9.6e-142	482.0	COG0484@1|root,COG0484@2|Bacteria,1Q629@1224|Proteobacteria,2VJ8G@28216|Betaproteobacteria,1KNFS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD2_k127_4408591_1	395495.Lcho_1541	1.851e-282	878.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2VPQ6@28216|Betaproteobacteria	28216|Betaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HFD2_k127_4408591_11	395495.Lcho_1540	9.263e-75	263.0	COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,2VRX3@28216|Betaproteobacteria	28216|Betaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4408591_15	1286631.X805_07280	1.378e-38	156.0	COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2VNCP@28216|Betaproteobacteria,1KKBD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_4408591_16	1157708.KB907456_gene2236	6.039e-36	150.0	COG1247@1|root,COG1247@2|Bacteria,1QVS0@1224|Proteobacteria,2W2KH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_4408591_18	543728.Vapar_0446	0.000778	46.0	2DWUK@1|root,341YV@2|Bacteria,1NYVW@1224|Proteobacteria,2W3QH@28216|Betaproteobacteria,4AI5M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2917)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2917
HFD2_k127_4408591_10	1122604.JONR01000009_gene2440	5.917e-91	311.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RZ74@1236|Gammaproteobacteria,1X6N8@135614|Xanthomonadales	135614|Xanthomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4408591_3	420662.Mpe_A1086	3.937e-213	675.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,1KIVM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC-type Fe3 transport system, permease component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD2_k127_4408591_5	420662.Mpe_A1085	4.869e-175	555.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,1KJ77@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HFD2_k127_4408591_2	420662.Mpe_A1084	4.874e-245	765.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,1KJHF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HFD2_k127_4408591_8	1265502.KB905932_gene1786	5.645e-116	401.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,4AA9H@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD2_k127_4408591_9	543728.Vapar_3817	3.426e-102	340.0	COG2188@1|root,COG2188@2|Bacteria,1R790@1224|Proteobacteria,2VKB7@28216|Betaproteobacteria,4AGM9@80864|Comamonadaceae	28216|Betaproteobacteria	K	UTRA domain	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HFD2_k127_4408591_14	716544.wcw_1759	1.11e-39	158.0	COG0483@1|root,COG0483@2|Bacteria,2JFWI@204428|Chlamydiae	204428|Chlamydiae	G	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_4408591_7	1286631.X805_12670	1.773e-135	436.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,1KJJK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD2_k127_4408591_4	983917.RGE_37670	2.523e-177	560.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,1KIWQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the arginase family	rocF	-	3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7	ko:K01476,ko:K01480,ko:K12255,ko:K18459	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157,R01990	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD2_k127_4408591_13	420662.Mpe_A1079	1.658e-45	171.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VSZM@28216|Betaproteobacteria,1KMPP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HFD2_k127_4408591_0	864051.BurJ1DRAFT_3757	0.0	1220.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,1KJC3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	helicase superfamily c-terminal domain	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HFD2_k127_4408591_12	1095769.CAHF01000021_gene895	2.777e-72	265.0	COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,2VNMR@28216|Betaproteobacteria,473GG@75682|Oxalobacteraceae	28216|Betaproteobacteria	GM	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_3,Epimerase,NAD_binding_10
HFD2_k127_4408591_17	857087.Metme_3771	4.746e-17	84.0	COG3011@1|root,COG3011@2|Bacteria,1N08P@1224|Proteobacteria,1S8S3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HFD2_k127_4408600_7	1265502.KB905930_gene1501	8.615e-44	159.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,4ACDR@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	gstI	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2
HFD2_k127_4408600_4	987059.RBXJA2T_19661	1.743e-64	235.0	COG3597@1|root,COG3597@2|Bacteria,1RKKI@1224|Proteobacteria,2VU6W@28216|Betaproteobacteria,1KMJH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4408600_0	395495.Lcho_2226	0.0	2011.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,1KJBK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HFD2_k127_4408600_5	395495.Lcho_2227	8.766e-47	175.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2VV6T@28216|Betaproteobacteria,1KM93@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_4408600_1	395495.Lcho_2228	7.177e-256	794.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,1KJ7S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
HFD2_k127_4408600_6	1265502.KB905930_gene1497	1.337e-46	171.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,4AEC5@80864|Comamonadaceae	28216|Betaproteobacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	yggX	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HFD2_k127_4408600_3	864051.BurJ1DRAFT_2893	2.797e-168	534.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,1KK62@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	fbpA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD2_k127_4408600_9	864051.BurJ1DRAFT_2894	1.575e-28	117.0	COG2916@1|root,COG2916@2|Bacteria,1N7YA@1224|Proteobacteria,2VW5J@28216|Betaproteobacteria,1KM8S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Histone family protein nucleoid-structuring protein H-NS	-	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
HFD2_k127_4408600_2	983917.RGE_27040	4.283e-226	713.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,1KK4K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HFD2_k127_4408600_8	420662.Mpe_A2491	5.507e-29	125.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1KJFB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_4437289_2	420324.KI912002_gene8463	1.913e-69	250.0	COG0627@1|root,COG0627@2|Bacteria,1MX6W@1224|Proteobacteria,2TSCC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_4437289_4	365044.Pnap_1802	7.312e-57	201.0	COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,2VV4U@28216|Betaproteobacteria,4AF66@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HFD2_k127_4437289_3	358220.C380_08980	6.925e-65	229.0	COG0454@1|root,COG0454@2|Bacteria,1QU5Y@1224|Proteobacteria,2WHF8@28216|Betaproteobacteria,4AJVV@80864|Comamonadaceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_4437289_0	420662.Mpe_A1011	0.0	1350.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1KIV3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Succinyl-CoA ligase like flavodoxin domain	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_4437289_7	626418.bglu_1g10800	1.508e-28	130.0	COG0642@1|root,COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HFD2_k127_4437289_1	420662.Mpe_A3048	5.192e-106	360.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,1KJI4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HFD2_k127_4437289_6	1038858.AXBA01000031_gene2830	2.5e-45	172.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2TQUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HFD2_k127_4464924_4	983917.RGE_34980	9.514e-144	459.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2VJ92@28216|Betaproteobacteria,1KKEU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_4464924_1	983917.RGE_34970	3.131e-195	621.0	COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2VK8I@28216|Betaproteobacteria,1KJ2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_4464924_2	983917.RGE_34960	9.177e-192	602.0	COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,2VICQ@28216|Betaproteobacteria,1KKHZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HFD2_k127_4464924_3	543728.Vapar_4696	5.823e-164	547.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,4AAJ2@80864|Comamonadaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
HFD2_k127_4464924_0	543728.Vapar_4695	6.704e-230	717.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VJIT@28216|Betaproteobacteria,4AC6D@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22,2.6.1.76	ko:K00823,ko:K00836,ko:K07250	ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R04188,R06977	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_447568_1	395495.Lcho_0138	8.955e-157	499.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2VMDW@28216|Betaproteobacteria,1KJYJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10227	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_447568_2	1123504.JQKD01000002_gene3783	1.891e-61	218.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2VKQS@28216|Betaproteobacteria,4AC8E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM NADPH-dependent FMN reductase	azr	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HFD2_k127_447568_3	397945.Aave_3558	1.026e-41	171.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,2VTZW@28216|Betaproteobacteria,4AID8@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF305)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HFD2_k127_447568_0	1003200.AXXA_01110	1.781e-266	837.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,3T57X@506|Alcaligenaceae	28216|Betaproteobacteria	L	Superfamily I DNA and RNA helicases	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_447568_4	58123.JOFJ01000029_gene1152	2.792e-09	70.0	COG0784@1|root,COG0784@2|Bacteria,2GRPA@201174|Actinobacteria	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_4484961_6	420662.Mpe_A2863	2.813e-39	150.0	COG1516@1|root,COG1516@2|Bacteria,1N4VX@1224|Proteobacteria,2VU8N@28216|Betaproteobacteria,1KM8H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar protein FliT	fliT	-	-	ko:K02423	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliT
HFD2_k127_4484961_7	864051.BurJ1DRAFT_1318	4.204e-37	160.0	COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,2VU2S@28216|Betaproteobacteria,1KMEN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
HFD2_k127_4484961_0	395495.Lcho_1011	2.215e-116	390.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,1KK2R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
HFD2_k127_4484961_3	1236959.BAMT01000016_gene2790	4.281e-96	322.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,2KM4H@206350|Nitrosomonadales	206350|Nitrosomonadales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HFD2_k127_4484961_2	1538295.JY96_16630	5.461e-97	323.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,1KKEX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
HFD2_k127_4484961_1	1538295.JY96_16680	1.484e-108	364.0	COG0463@1|root,COG0463@2|Bacteria,1P77I@1224|Proteobacteria,2VPIE@28216|Betaproteobacteria,1KNB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD2_k127_4484961_5	1366050.N234_16655	1.032e-40	159.0	COG0110@1|root,COG0110@2|Bacteria,1MZ7U@1224|Proteobacteria,2VVVZ@28216|Betaproteobacteria,1K3EF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K13006,ko:K19429	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
HFD2_k127_4484961_4	1538295.JY96_06575	2.991e-50	183.0	2AX91@1|root,31P80@2|Bacteria,1N25K@1224|Proteobacteria,2VSYQ@28216|Betaproteobacteria,1KM49@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways	flhD	-	-	ko:K02403	ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlhD
HFD2_k127_4494595_0	983917.RGE_14770	2.861e-83	294.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg
HFD2_k127_4494595_1	1120999.JONM01000007_gene1774	1.067e-56	203.0	COG3832@1|root,COG3832@2|Bacteria,1RA7N@1224|Proteobacteria,2VU3U@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_4494595_5	1120999.JONM01000007_gene1775	2.41e-09	59.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,2VVH0@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_4494595_4	1122604.JONR01000020_gene443	6.126e-15	85.0	COG2128@1|root,COG2128@2|Bacteria,1MWWX@1224|Proteobacteria,1TCE6@1236|Gammaproteobacteria,1XAEQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_4494595_2	1333998.M2A_3176	1.294e-28	119.0	COG1733@1|root,COG1733@2|Bacteria,1N0WG@1224|Proteobacteria,2U9MA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD2_k127_4494595_3	1005048.CFU_2948	2.185e-18	92.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,475ZW@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD2_k127_4500193_1	322710.Avin_07120	2.393e-103	353.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD2_k127_4500193_4	426114.THI_0622	8.647e-28	121.0	2E53B@1|root,32ZWF@2|Bacteria,1N7G8@1224|Proteobacteria,2VVPD@28216|Betaproteobacteria,1KMI8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4500193_0	760117.JN27_01790	9.498e-138	452.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VJ0F@28216|Betaproteobacteria,4732E@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.17.2.1	ko:K18030	ko00760,ko01120,map00760,map01120	M00622	R09473	RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_4500193_3	640511.BC1002_5511	1.89e-63	229.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2W28J@28216|Betaproteobacteria,1KH6E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	2Fe-2S -binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HFD2_k127_4500193_2	113395.AXAI01000002_gene5390	1.095e-87	306.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_4516901_0	1286631.X805_19980	1.505e-314	973.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2VHH2@28216|Betaproteobacteria,1KK1Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_4516901_5	864051.BurJ1DRAFT_1587	2.977e-96	319.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2VQWM@28216|Betaproteobacteria,1KJU8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD2_k127_4516901_7	365046.Rta_11380	2.735e-67	233.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,4AE81@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_4516901_6	279714.FuraDRAFT_2206	3.193e-69	241.0	COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,2VPWT@28216|Betaproteobacteria,2KS1M@206351|Neisseriales	206351|Neisseriales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_4516901_8	420662.Mpe_A2923	3.884e-67	231.0	COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2VT0A@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_4516901_1	420662.Mpe_A2922	3.404e-177	565.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,1KK9B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_4516901_11	745310.G432_00920	8.055e-37	155.0	COG3791@1|root,COG3791@2|Bacteria,1RE8S@1224|Proteobacteria,2U73V@28211|Alphaproteobacteria,2K4NT@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD2_k127_4516901_4	987059.RBXJA2T_14881	1.337e-102	356.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2VM30@28216|Betaproteobacteria,1KK0M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_4516901_3	983917.RGE_34420	3.742e-122	409.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,2VIZ8@28216|Betaproteobacteria,1KJAI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD2_k127_4516901_10	420662.Mpe_A1356	7.075e-40	154.0	COG2913@1|root,COG2913@2|Bacteria,1N0IW@1224|Proteobacteria,2VUU7@28216|Betaproteobacteria,1KMJT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4516901_9	596154.Alide2_3417	6.981e-43	168.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2VUB7@28216|Betaproteobacteria,4AF35@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ArsC family	yffB	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HFD2_k127_4516901_2	395495.Lcho_2110	1.15e-147	478.0	COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2VISN@28216|Betaproteobacteria,1KIUS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation,HEAT
HFD2_k127_4517348_1	365046.Rta_02310	5.276e-179	567.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,4A9UD@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HFD2_k127_4517348_9	420662.Mpe_A0217	2.758e-51	201.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,1KM9B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HFD2_k127_4517348_2	420662.Mpe_A0216	6.63e-168	537.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,1KJ0R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
HFD2_k127_4517348_4	420662.Mpe_A0213	6.073e-123	401.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VIH8@28216|Betaproteobacteria,1KJ19@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	2-hydroxyacid dehydrogenase	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
HFD2_k127_4517348_8	983917.RGE_45200	2.05e-53	201.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,1KM1A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HFD2_k127_4517348_6	420662.Mpe_A0211	2.748e-71	246.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,1KM28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HFD2_k127_4517348_3	864051.BurJ1DRAFT_4658	2.351e-148	475.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,1KJX4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_4517348_10	1158318.ATXC01000001_gene492	3.562e-17	92.0	COG0330@1|root,COG0330@2|Bacteria,2G4WR@200783|Aquificae	200783|Aquificae	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD2_k127_4517348_5	983917.RGE_45230	1.854e-91	317.0	COG4566@1|root,COG4566@2|Bacteria,1RAEP@1224|Proteobacteria,2WEEG@28216|Betaproteobacteria,1KKKF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	dctR	-	-	ko:K11712	ko02020,map02020	-	-	-	ko00000,ko00001,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_4517348_0	1265502.KB905939_gene2329	3.163e-266	842.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,4ABX9@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	dctS	-	2.7.13.3	ko:K11711	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HFD2_k127_4517348_7	983917.RGE_45250	5.583e-63	223.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1KIY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
HFD2_k127_4542227_2	1286631.X805_03010	2.675e-136	439.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,1KJ0S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD2_k127_4542227_0	420662.Mpe_A3382	5.784e-198	627.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2VIRM@28216|Betaproteobacteria,1KMM7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,p450
HFD2_k127_4542227_1	397945.Aave_4178	1.118e-173	559.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,4ABB7@80864|Comamonadaceae	28216|Betaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HFD2_k127_4544853_2	189753.AXAS01000017_gene3168	8.017e-13	68.0	COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,2U6NI@28211|Alphaproteobacteria,3JYFN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_4544853_0	1502852.FG94_03568	5.993e-35	145.0	COG2372@1|root,COG3133@1|root,COG2372@2|Bacteria,COG3133@2|Bacteria,1NZWY@1224|Proteobacteria,2W43X@28216|Betaproteobacteria	28216|Betaproteobacteria	M	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4544853_1	553217.ENHAE0001_1885	1.241e-33	151.0	COG0772@1|root,COG0772@2|Bacteria,1NU9N@1224|Proteobacteria,1SKT0@1236|Gammaproteobacteria,3NR6E@468|Moraxellaceae	1236|Gammaproteobacteria	D	Cell cycle protein	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
HFD2_k127_4552757_1	864051.BurJ1DRAFT_4810	1.226e-215	680.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,1KJF7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD2_k127_4552757_2	420662.Mpe_A3005	2.001e-128	416.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,1KJNT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	dienelactone hydrolase	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD2_k127_4552757_4	864051.BurJ1DRAFT_4817	3.195e-120	392.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,1KK9F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
HFD2_k127_4552757_7	987059.RBXJA2T_00560	1.699e-67	231.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VSW6@28216|Betaproteobacteria,1KKTH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_4552757_6	420662.Mpe_A2636	1.286e-95	335.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1KJDB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD2_k127_4552757_3	1265502.KB905933_gene2048	1.38e-124	406.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,4ABTF@80864|Comamonadaceae	28216|Betaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HFD2_k127_4552757_8	1265502.KB905933_gene2037	3.631e-60	211.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,4ADWN@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD2_k127_4552757_0	1265502.KB905933_gene2036	0.0	1086.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,4A9NH@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HFD2_k127_4552757_9	395495.Lcho_0121	1.003e-50	199.0	COG3109@1|root,COG3109@2|Bacteria,1PS29@1224|Proteobacteria,2VU30@28216|Betaproteobacteria,1KM9F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	ProQ/FINO family	proQ	-	-	ko:K03607	-	-	-	-	ko00000	-	-	-	ProQ
HFD2_k127_4552757_5	1123255.JHYS01000009_gene2342	2.46e-96	322.0	COG1801@1|root,COG1801@2|Bacteria,1N06I@1224|Proteobacteria,2VJZZ@28216|Betaproteobacteria,4AJ47@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_4559137_3	983917.RGE_13170	6.133e-17	87.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,1KIWX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HFD2_k127_4559137_2	864051.BurJ1DRAFT_3125	4.254e-44	173.0	2FEFF@1|root,346F4@2|Bacteria,1NZUX@1224|Proteobacteria,2W4QF@28216|Betaproteobacteria,1KNVR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4559137_1	1265502.KB905931_gene1602	2.569e-128	434.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJBJ@28216|Betaproteobacteria,4AEGS@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD2_k127_4559137_0	395495.Lcho_2651	2.773e-129	418.0	COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VK5Y@28216|Betaproteobacteria,1KJ8U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
HFD2_k127_4573046_3	1286631.X805_26850	1.222e-102	347.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2VIK4@28216|Betaproteobacteria,1KJX1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
HFD2_k127_4573046_5	864051.BurJ1DRAFT_1030	1.932e-44	166.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VTXY@28216|Betaproteobacteria,1KNI3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD2_k127_4573046_4	269482.Bcep1808_6012	3.196e-96	329.0	297UU@1|root,2ZV1D@2|Bacteria,1MXFE@1224|Proteobacteria,2VIEE@28216|Betaproteobacteria,1K5E5@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4573046_0	987059.RBXJA2T_11478	5.228e-123	402.0	28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,2VJQS@28216|Betaproteobacteria,1KJA9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Dinitrogenase reductase ADP-ribosyltransferase (DRAT)	draT	-	2.4.2.37	ko:K05951	-	-	-	-	ko00000,ko01000	-	-	-	DRAT
HFD2_k127_4573046_1	987059.RBXJA2T_11483	3.12e-118	391.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria,1KJKZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ADP-ribosyl-(Dinitrogen reductase) hydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
HFD2_k127_4573046_7	983917.RGE_42830	4.124e-23	101.0	COG2331@1|root,COG2331@2|Bacteria,1N8DC@1224|Proteobacteria,2VWBQ@28216|Betaproteobacteria,1KMIH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD2_k127_4573046_6	395495.Lcho_1417	2.225e-41	166.0	COG0633@1|root,COG0633@2|Bacteria,1PQE9@1224|Proteobacteria,2VUDT@28216|Betaproteobacteria,1KMET@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HFD2_k127_4573046_2	1286631.X805_26690	5.637e-117	379.0	28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,2VM9W@28216|Betaproteobacteria,1KKB0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
HFD2_k127_4585274_2	864051.BurJ1DRAFT_1132	1.915e-116	379.0	COG2038@1|root,COG2038@2|Bacteria,1R4EY@1224|Proteobacteria,2VPTK@28216|Betaproteobacteria,1KJFY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Phosphoribosyltransferase	-	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HFD2_k127_4585274_11	420662.Mpe_A3127	6.2e-35	152.0	2DP58@1|root,32UKC@2|Bacteria,1N8RA@1224|Proteobacteria,2VW6I@28216|Betaproteobacteria,1KMMH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	general secretion pathway protein	gspC	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
HFD2_k127_4585274_7	420662.Mpe_A3128	4.264e-66	240.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,1KKMN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	general secretion pathway protein	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HFD2_k127_4585274_8	420662.Mpe_A3129	5.728e-41	156.0	COG2165@1|root,COG2165@2|Bacteria,1NFU8@1224|Proteobacteria,2WHFI@28216|Betaproteobacteria,1KPD8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HFD2_k127_4585274_9	395495.Lcho_3421	4.965e-40	159.0	COG2165@1|root,COG2165@2|Bacteria,1N0C2@1224|Proteobacteria,2VVJ8@28216|Betaproteobacteria,1KM8V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	general secretion pathway protein	gspI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
HFD2_k127_4585274_6	420662.Mpe_A3131	1.078e-68	239.0	COG4795@1|root,COG4795@2|Bacteria,1RJBJ@1224|Proteobacteria,2WGMU@28216|Betaproteobacteria,1KM0R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Prokaryotic N-terminal methylation motif	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HFD2_k127_4585274_4	420662.Mpe_A3132	1.288e-98	341.0	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria,1KK5C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HFD2_k127_4585274_1	420662.Mpe_A3133	9.7e-128	421.0	COG3297@1|root,COG3297@2|Bacteria,1MX9I@1224|Proteobacteria,2VH8V@28216|Betaproteobacteria,1KJQQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	General secretion pathway	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
HFD2_k127_4585274_10	420662.Mpe_A3134	5.747e-40	158.0	COG3149@1|root,COG3149@2|Bacteria,1N133@1224|Proteobacteria,2VUUD@28216|Betaproteobacteria,1KMCM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM General secretion pathway, M protein	gspM	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
HFD2_k127_4585274_5	420662.Mpe_A3135	9.525e-93	323.0	28IWK@1|root,2Z8UV@2|Bacteria,1P9EC@1224|Proteobacteria,2VJZY@28216|Betaproteobacteria,1KKND@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Type II secretion system (T2SS), protein N	gspN	-	-	ko:K02463	ko05111,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSN
HFD2_k127_4585274_0	864051.BurJ1DRAFT_1122	2.685e-273	875.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1KK85@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	general secretion pathway protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HFD2_k127_4585274_3	864051.BurJ1DRAFT_1121	7.035e-100	328.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KK8F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	TIGRFAM general secretory pathway protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HFD2_k127_4595083_3	398578.Daci_0725	4.045e-41	168.0	2C5G6@1|root,33Q77@2|Bacteria,1PVA5@1224|Proteobacteria,2WB6H@28216|Betaproteobacteria,4AH0P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sel1 repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4595083_1	987059.RBXJA2T_18939	3.224e-86	301.0	COG3203@1|root,COG3203@2|Bacteria,1R5T2@1224|Proteobacteria,2VMH6@28216|Betaproteobacteria,1KPGF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_4595083_2	397945.Aave_3911	5.894e-71	262.0	COG0583@1|root,COG0583@2|Bacteria,1R74J@1224|Proteobacteria,2VNHS@28216|Betaproteobacteria,4AAX6@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4595083_0	1218084.BBJK01000003_gene543	1.211e-127	413.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VKW0@28216|Betaproteobacteria,1K459@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4600756_0	1268622.AVS7_00853	2.677e-252	798.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4ACAD@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	gmr	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,MHYT
HFD2_k127_4600756_1	296591.Bpro_1756	2.355e-159	529.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,4ABSP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HFD2_k127_4600756_2	1265502.KB905943_gene2777	6.64e-133	430.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,4AEPS@80864|Comamonadaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4600756_4	1265502.KB905943_gene2776	5.528e-92	308.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2VK5E@28216|Betaproteobacteria,4AAXC@80864|Comamonadaceae	28216|Betaproteobacteria	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HFD2_k127_4600756_3	420662.Mpe_A0054	3.857e-94	335.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,1KKS0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phospholipase/Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
HFD2_k127_4600756_5	573.JG24_06700	3.719e-75	255.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RPIE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_4605814_0	543728.Vapar_0393	1.912e-210	668.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HFD2_k127_4605814_4	395495.Lcho_0426	7.818e-48	175.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2VSM2@28216|Betaproteobacteria,1KM6D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HFD2_k127_4605814_2	1538295.JY96_10145	2.188e-186	588.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,1KJ4C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD2_k127_4605814_3	395495.Lcho_0428	2.695e-73	250.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,1KKSX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_4605814_1	1265502.KB905937_gene2568	2.124e-193	610.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,4AA3J@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD2_k127_4605814_5	1095769.CAHF01000005_gene1586	2.351e-10	61.0	COG2340@1|root,COG2340@2|Bacteria,1MZ84@1224|Proteobacteria,2VV1E@28216|Betaproteobacteria,477U9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HFD2_k127_4616192_8	522306.CAP2UW1_0893	8.546e-73	264.0	COG1520@1|root,COG4249@1|root,COG1520@2|Bacteria,COG4249@2|Bacteria,1NJ33@1224|Proteobacteria,2VYNA@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HFD2_k127_4616192_13	1120999.JONM01000003_gene2727	7.8e-17	97.0	COG0737@1|root,COG0737@2|Bacteria,1MU11@1224|Proteobacteria,2VJC2@28216|Betaproteobacteria,2KQCH@206351|Neisseriales	206351|Neisseriales	F	5'-nucleotidase, C-terminal domain	cpdB	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HFD2_k127_4616192_12	483219.LILAB_18585	1.661e-26	129.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria	2|Bacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Big_2,CHU_C,RCC1
HFD2_k127_4616192_11	202952.BBLI01000030_gene2218	2.602e-67	263.0	COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NN17@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,VCBS
HFD2_k127_4616192_6	864051.BurJ1DRAFT_2541	1.483e-103	349.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HFD2_k127_4616192_5	987059.RBXJA2T_05273	4.435e-111	365.0	COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,2VIHN@28216|Betaproteobacteria,1KJHN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HFD2_k127_4616192_9	395495.Lcho_0943	2.674e-72	258.0	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1QF7R@1224|Proteobacteria,2VP9G@28216|Betaproteobacteria,1KJUA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0149)	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HFD2_k127_4616192_10	296591.Bpro_1165	1.307e-70	246.0	COG2188@1|root,COG2188@2|Bacteria,1MVFM@1224|Proteobacteria,2VK47@28216|Betaproteobacteria,4AJ6A@80864|Comamonadaceae	28216|Betaproteobacteria	K	UTRA	hutC	-	-	ko:K05836	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HFD2_k127_4616192_0	1265502.KB905970_gene1309	1.078e-179	575.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,4AAID@80864|Comamonadaceae	28216|Betaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD2_k127_4616192_2	688245.CtCNB1_0162	4.026e-125	406.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,4ACPW@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	cmpD_2	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_4616192_3	1211115.ALIQ01000071_gene3808	2.895e-123	399.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	MA20_34185	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_4616192_1	1038859.AXAU01000024_gene4022	1.383e-149	479.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2TTB8@28211|Alphaproteobacteria,3JVA6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	MA20_34190	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD2_k127_4616192_7	1502852.FG94_02952	1.852e-93	333.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2VK2Y@28216|Betaproteobacteria,473YF@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.1.68,3.5.3.8	ko:K01458,ko:K01479	ko00340,ko00630,ko01100,map00340,map00630,map01100	M00045	R00525,R02285	RC00165,RC00221,RC00323,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
HFD2_k127_4616192_4	388051.AUFE01000008_gene1624	4.157e-115	377.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2VK8A@28216|Betaproteobacteria,1JZYP@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Imidazolone-5-propionate hydrolase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD2_k127_4619376_4	358220.C380_03695	3.197e-92	304.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2VIFV@28216|Betaproteobacteria,4ABQ9@80864|Comamonadaceae	28216|Betaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HFD2_k127_4619376_1	864051.BurJ1DRAFT_0496	1.987e-223	702.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,1KK09@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HFD2_k127_4619376_3	987059.RBXJA2T_01765	1.532e-111	368.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2VK1G@28216|Betaproteobacteria,1KJ92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33,6.3.4.15	ko:K01947,ko:K03525	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Pan_kinase
HFD2_k127_4619376_6	395495.Lcho_3840	3.446e-23	109.0	2EGTR@1|root,33AJW@2|Bacteria,1NN4K@1224|Proteobacteria,2VY7S@28216|Betaproteobacteria,1KMR0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4619376_2	358220.C380_01045	1.269e-123	402.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VJ7N@28216|Betaproteobacteria,4AC35@80864|Comamonadaceae	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HFD2_k127_4619376_0	420662.Mpe_A0903	0.0	1914.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1KJWN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HFD2_k127_4619376_7	1458357.BG58_38805	3.073e-22	106.0	COG2010@1|root,COG2010@2|Bacteria,1Q0HB@1224|Proteobacteria,2W5B8@28216|Betaproteobacteria,1KE1E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_4619376_5	1349767.GJA_3247	3.646e-42	164.0	29DRS@1|root,300PM@2|Bacteria,1RF8B@1224|Proteobacteria,2VR3X@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4628959_0	864051.BurJ1DRAFT_2487	2.504e-206	647.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,1KKBU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_4628959_2	296591.Bpro_2634	1.085e-142	456.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,4A9RA@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_4628959_6	1249627.D779_0782	3.938e-09	64.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_4628959_4	987059.RBXJA2T_12212	9.427e-63	222.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,1KKZC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Cell wall-associated	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
HFD2_k127_4628959_1	1265502.KB905935_gene3084	2.345e-185	599.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4AB8M@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HFD2_k127_4628959_5	1265502.KB905935_gene3087	1.865e-41	175.0	COG1670@1|root,COG1670@2|Bacteria,1QW54@1224|Proteobacteria,2WHT5@28216|Betaproteobacteria	28216|Betaproteobacteria	J	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD2_k127_4628959_3	388051.AUFE01000003_gene715	1.159e-119	407.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_4637080_3	266834.SM_b20931	7.237e-28	116.0	COG1879@1|root,COG1879@2|Bacteria,1R6D7@1224|Proteobacteria,2U3VS@28211|Alphaproteobacteria,4B7HY@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	sugar ABC transporter substrate-binding protein	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_4637080_0	596153.Alide_2164	1.701e-242	756.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,4AA30@80864|Comamonadaceae	28216|Betaproteobacteria	J	ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD2_k127_4637080_1	987059.RBXJA2T_06340	4.593e-71	253.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,1KKU4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD2_k127_4637080_2	987059.RBXJA2T_00260	7.04e-66	231.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,1KKWH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD2_k127_4645095_2	420662.Mpe_A1525	3.529e-238	742.0	COG3064@1|root,COG4147@1|root,COG3064@2|Bacteria,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,1KJ8P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP_1	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HFD2_k127_4645095_15	1265502.KB905935_gene3028	1.005e-41	154.0	COG4327@1|root,COG4327@2|Bacteria,1NQBY@1224|Proteobacteria,2VV4C@28216|Betaproteobacteria,4AFHH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
HFD2_k127_4645095_13	1265502.KB905935_gene3029	8.407e-71	247.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,4AEDK@80864|Comamonadaceae	28216|Betaproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HFD2_k127_4645095_19	1265502.KB905935_gene3030	1.285e-21	99.0	2E807@1|root,332EI@2|Bacteria,1NAEI@1224|Proteobacteria,2VVPC@28216|Betaproteobacteria,4AFD7@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4645095_17	420662.Mpe_A3573	1.262e-27	121.0	COG3266@1|root,COG3266@2|Bacteria,1N9M2@1224|Proteobacteria,2VXAE@28216|Betaproteobacteria,1KMIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4645095_1	887062.HGR_04119	9.485e-242	767.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,4AA9Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP_1	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HFD2_k127_4645095_20	983917.RGE_36760	9.679e-17	86.0	COG4327@1|root,COG4327@2|Bacteria,1PTW9@1224|Proteobacteria,2WAMT@28216|Betaproteobacteria,1KMJ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
HFD2_k127_4645095_4	983917.RGE_18490	5.745e-202	631.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,1KJTM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD2_k127_4645095_14	1286631.X805_30830	6.572e-70	258.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VQN2@28216|Betaproteobacteria,1KKP7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD2_k127_4645095_0	1265502.KB905929_gene2199	0.0	1367.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,4ABDB@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HFD2_k127_4645095_6	1286631.X805_30850	2.723e-189	601.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KJW8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HFD2_k127_4645095_12	864051.BurJ1DRAFT_3748	5.022e-87	292.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2VJR8@28216|Betaproteobacteria,1KMNR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD2_k127_4645095_3	395495.Lcho_1277	2.036e-222	706.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2VHFM@28216|Betaproteobacteria,1KP9M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HFD2_k127_4645095_9	395495.Lcho_1274	2.744e-166	529.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2VIBF@28216|Betaproteobacteria,1KM5Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	yejB	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HFD2_k127_4645095_10	1458275.AZ34_10060	1.06e-144	482.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2VHVN@28216|Betaproteobacteria,4AAK4@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	dppC2	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HFD2_k127_4645095_8	395495.Lcho_1272	2.051e-174	575.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1KJMZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	-	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HFD2_k127_4645095_18	391613.RTM1035_01440	1.007e-21	95.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,46NJU@74030|Roseovarius	28211|Alphaproteobacteria	P	Oligopeptide dipeptide uptake family ABC transporter, ATP-binding protein	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HFD2_k127_4645095_11	859657.RPSI07_mp0829	3.403e-144	484.0	COG3533@1|root,COG4733@1|root,COG3533@2|Bacteria,COG4733@2|Bacteria,1NJBA@1224|Proteobacteria,2VNM3@28216|Betaproteobacteria,1K271@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Laminin_G_3
HFD2_k127_4645095_5	1120999.JONM01000027_gene479	6.448e-193	623.0	28WH1@1|root,2ZIH5@2|Bacteria,1R9QX@1224|Proteobacteria,2VP58@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4645095_7	1123487.KB892835_gene3508	1.416e-177	579.0	COG3391@1|root,COG5520@1|root,COG3391@2|Bacteria,COG5520@2|Bacteria,1PHND@1224|Proteobacteria,2W42A@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl hydrolase family 30 TIM-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_30
HFD2_k127_4645095_16	1282362.AEAC466_07745	9.66e-32	125.0	COG4447@1|root,COG4447@2|Bacteria,1MVMU@1224|Proteobacteria,2U98D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4645095_21	426117.M446_2791	1.183e-11	78.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JU2Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_8,Trans_reg_C
HFD2_k127_4651817_1	1100720.ALKN01000026_gene1697	1.115e-174	550.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,4AGKN@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_4651817_0	420662.Mpe_A2558	0.0	1186.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,1KJHR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD2_k127_4651817_4	987059.RBXJA2T_05208	6.339e-61	225.0	2EAQM@1|root,334SV@2|Bacteria,1N39W@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4651817_2	987059.RBXJA2T_05213	5.739e-114	392.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VJK2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19,TPR_8
HFD2_k127_4651817_5	987059.RBXJA2T_05218	1.069e-56	211.0	2EDW0@1|root,32VXH@2|Bacteria,1Q0AC@1224|Proteobacteria,2W51V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4651817_3	1198452.Jab_1c13900	3.039e-71	255.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2VN0T@28216|Betaproteobacteria,477CK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	methyltransferase (Contains TPR repeat)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_1,TPR_10,TPR_11,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
HFD2_k127_4651817_7	864051.BurJ1DRAFT_2809	3.87e-37	149.0	COG1495@1|root,COG1495@2|Bacteria,1N0J6@1224|Proteobacteria,2VTZK@28216|Betaproteobacteria,1KMCI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	bond formation protein DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HFD2_k127_4651817_6	1286631.X805_16480	5.559e-43	158.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,1KKJT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	tdcF2	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HFD2_k127_466206_1	1265502.KB905929_gene2270	7.055e-132	431.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,4ACIR@80864|Comamonadaceae	28216|Betaproteobacteria	NU	pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
HFD2_k127_466206_2	864051.BurJ1DRAFT_3940	5.309e-121	394.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,1KJ1J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD2_k127_466206_4	420662.Mpe_A2158	9.412e-100	339.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,1KK51@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HFD2_k127_466206_0	420662.Mpe_A2157	1.805e-235	732.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,1KITB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_466206_3	420662.Mpe_A2156	2.233e-118	406.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1KJQR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HFD2_k127_466206_5	1538295.JY96_18090	8.72e-97	319.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,1KIW6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_4740839_1	1229205.BUPH_01042	6.041e-190	600.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,1K42C@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	mdeA_1	-	2.5.1.48,2.5.1.49	ko:K01739,ko:K01740	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_4740839_2	1538295.JY96_09820	6.134e-98	325.0	COG0745@1|root,COG0745@2|Bacteria,1MZQA@1224|Proteobacteria,2VQYI@28216|Betaproteobacteria,1KKPV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_4740839_0	420662.Mpe_A0810	0.0	1223.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KJBE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_4740839_3	987059.RBXJA2T_04303	1.241e-51	186.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,1KK28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Extradiol ring-cleavage dioxygenase, class III	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_4740839_4	864051.BurJ1DRAFT_4790	2.129e-38	148.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,1KK28@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Extradiol ring-cleavage dioxygenase, class III	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HFD2_k127_4783891_3	1276756.AUEX01000001_gene1021	1.101e-71	249.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,4AAYK@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_4783891_2	1265502.KB905962_gene372	7.671e-99	331.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2VMPA@28216|Betaproteobacteria,4A9Y1@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
HFD2_k127_4783891_0	1265502.KB905962_gene373	6.025e-209	654.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,4AAW1@80864|Comamonadaceae	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_4783891_4	983917.RGE_45050	1.001e-68	241.0	COG0784@1|root,COG0784@2|Bacteria,1RGD3@1224|Proteobacteria,2VUMK@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
HFD2_k127_4783891_1	395495.Lcho_3216	1.848e-153	505.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1KISZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K03776,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS,PAS_3,PAS_8,TarH,sCache_2
HFD2_k127_4786512_4	420662.Mpe_A0755	3.489e-152	489.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VH58@28216|Betaproteobacteria,1KJTY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM cytochrome c class I	-	-	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C
HFD2_k127_4786512_11	196367.JNFG01000041_gene7817	4.794e-113	379.0	COG0642@1|root,COG2205@2|Bacteria,1QV0D@1224|Proteobacteria,2WGP7@28216|Betaproteobacteria,1K67P@119060|Burkholderiaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,MEDS
HFD2_k127_4786512_19	883126.HMPREF9710_01169	2.065e-36	141.0	COG2261@1|root,COG2261@2|Bacteria,1N8B3@1224|Proteobacteria,2VWCP@28216|Betaproteobacteria,4754M@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD2_k127_4786512_20	1333523.L593_08855	1.122e-34	143.0	arCOG12705@1|root,arCOG12705@2157|Archaea,2Y5BC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4786512_14	296591.Bpro_1419	2.962e-93	314.0	COG1802@1|root,COG1802@2|Bacteria,1RCFJ@1224|Proteobacteria,2VIZT@28216|Betaproteobacteria,4AAZI@80864|Comamonadaceae	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_4786512_2	296591.Bpro_1420	1.355e-227	711.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VJ87@28216|Betaproteobacteria,4ABTN@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	dctA	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
HFD2_k127_4786512_15	296591.Bpro_2859	5.107e-93	314.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2VTNF@28216|Betaproteobacteria,4AF7C@80864|Comamonadaceae	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
HFD2_k127_4786512_18	1205680.CAKO01000029_gene5260	1.317e-41	157.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18
HFD2_k127_4786512_10	1038859.AXAU01000002_gene732	1.126e-117	387.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria,3JXD9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4786512_7	1265502.KB905946_gene1140	9.203e-144	464.0	COG2207@1|root,COG2207@2|Bacteria,1QUXX@1224|Proteobacteria,2WEJR@28216|Betaproteobacteria,4AA07@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HFD2_k127_4786512_3	1100720.ALKN01000040_gene2167	1.901e-210	693.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2VPWN@28216|Betaproteobacteria,4AC19@80864|Comamonadaceae	28216|Betaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_4786512_5	614083.AWQR01000007_gene375	8.541e-146	466.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2VHAJ@28216|Betaproteobacteria,4AB5H@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_4786512_6	887062.HGR_05324	1.18e-145	482.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2VNRM@28216|Betaproteobacteria,4AAJ7@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_4786512_9	1458427.BAWN01000007_gene494	3.187e-126	410.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2VP5B@28216|Betaproteobacteria,4AAZV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_4786512_8	1458275.AZ34_07635	9.588e-127	423.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VM1A@28216|Betaproteobacteria,4ACV1@80864|Comamonadaceae	28216|Betaproteobacteria	E	AAA domain	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_4786512_1	614083.AWQR01000007_gene379	4.123e-285	879.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VH71@28216|Betaproteobacteria,4ABR0@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_4786512_0	1282360.ABAC460_12980	0.0	1140.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,2U1U0@28211|Alphaproteobacteria,2KI71@204458|Caulobacterales	204458|Caulobacterales	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF5110,Glyco_hydro_31
HFD2_k127_4786512_24	1242864.D187_007904	9.319e-12	66.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YXF2@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_4786512_16	378806.STAUR_3819	1.648e-90	321.0	COG2755@1|root,COG2755@2|Bacteria,1P614@1224|Proteobacteria	1224|Proteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,DUF1080,Lipase_GDSL_2
HFD2_k127_4786512_23	1034769.KB910518_gene2222	4.927e-16	92.0	COG3507@1|root,COG3507@2|Bacteria,1TT53@1239|Firmicutes,4IPIB@91061|Bacilli,26VUU@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HFD2_k127_4786512_17	1177154.Y5S_02811	5.231e-56	205.0	COG4430@1|root,COG4430@2|Bacteria	2|Bacteria	F	Bacteriocin-protection, YdeI or OmpD-Associated	csaA	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	DUF1905,OmdA,tRNA_bind
HFD2_k127_4786512_13	420662.Mpe_A1310	5.834e-100	334.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria,1KNHQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD2_k127_4786512_12	159087.Daro_1389	4.896e-113	376.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2VMW2@28216|Betaproteobacteria,2KVZH@206389|Rhodocyclales	206389|Rhodocyclales	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD2_k127_4794515_1	395495.Lcho_1549	5.714e-262	818.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1KIYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD2_k127_4794515_12	420662.Mpe_A1212	2.641e-64	228.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1KKY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HFD2_k127_4794515_13	1163617.SCD_n02737	3.084e-09	68.0	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,2VY2T@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
HFD2_k127_4794515_5	420662.Mpe_A1213	1.06e-127	412.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,1KJXE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HFD2_k127_4794515_8	420662.Mpe_A1214	4.485e-85	287.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,1KKKI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HFD2_k127_4794515_11	420662.Mpe_A1215	1.97e-64	232.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,1KKZJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HFD2_k127_4794515_7	864051.BurJ1DRAFT_0154	9.503e-106	356.0	COG0625@1|root,COG0625@2|Bacteria,1NF66@1224|Proteobacteria,2VH33@28216|Betaproteobacteria,1KKBM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
HFD2_k127_4794515_4	864051.BurJ1DRAFT_0153	2.706e-186	593.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VJII@28216|Betaproteobacteria,1KJ4Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	PHB de-polymerase C-terminus	phaZ2	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HFD2_k127_4794515_0	987059.RBXJA2T_12837	0.0	1539.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC3	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD2_k127_4794515_6	987059.RBXJA2T_12832	1.429e-123	407.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,2VJVW@28216|Betaproteobacteria,1KJY9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	nolF	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD2_k127_4794515_3	1265502.KB905936_gene2640	8.116e-202	633.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,4AADA@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD2_k127_4794515_9	420662.Mpe_A1423	4.314e-79	269.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,1KKNW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_4794515_2	688245.CtCNB1_3246	2.44e-242	754.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,4AB52@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD2_k127_4794515_10	864051.BurJ1DRAFT_0841	8.65e-73	266.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,1KKJS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,FSH1
HFD2_k127_4812499_10	864051.BurJ1DRAFT_3442	6.251e-10	62.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,2VHD8@28216|Betaproteobacteria,1KJ5F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	May be involved in recombination	rdgC	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
HFD2_k127_4812499_8	395495.Lcho_0795	8.304e-52	184.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,2VSTW@28216|Betaproteobacteria,1KMGF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Rieske-like [2Fe-2S] domain	nagAb	-	-	ko:K05710,ko:K14578,ko:K14750	ko00360,ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00360,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220	M00534,M00545,M00638	R02968,R05422,R05423,R05424,R05425,R05426,R05427,R05440,R06782,R06783,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233	RC00091,RC00098,RC00157,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HFD2_k127_4812499_7	864051.BurJ1DRAFT_3283	2.811e-90	319.0	COG5517@1|root,COG5517@2|Bacteria,1RB82@1224|Proteobacteria,2VQ3X@28216|Betaproteobacteria,1KKVE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	SnoaL-like domain	nagH	-	1.14.12.1,1.14.13.172	ko:K16320,ko:K18243	ko00626,ko00627,ko01120,map00626,map00627,map01120	M00637,M00638	R00823,R00825,R07709,R07710	RC00192,RC00490	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Ring_hydroxyl_B,SnoaL_4
HFD2_k127_4812499_0	864051.BurJ1DRAFT_3284	3.507e-271	839.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,1KJMX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	nagG	-	1.14.12.1,1.14.13.172	ko:K16319,ko:K18242	ko00626,ko00627,ko01120,map00626,map00627,map01120	M00637,M00638	R00823,R00825,R07709,R07710	RC00192,RC00490	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HFD2_k127_4812499_1	395495.Lcho_0800	5.471e-189	594.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,2VIEW@28216|Betaproteobacteria,1KPMI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain	nagAa	-	1.17.1.1,1.18.1.7	ko:K00523,ko:K14581	ko00520,ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00520,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220	M00534,M00638	R02968,R03391,R03392,R05422,R05423,R05424,R05425,R05426,R05427,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233	RC00091,RC00098,RC00157,RC00230,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_4812499_2	395495.Lcho_0801	3.009e-168	531.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,1KM6C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_4812499_4	1286631.X805_34020	2.649e-154	507.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VI23@28216|Betaproteobacteria,1KMWM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_4812499_5	864051.BurJ1DRAFT_2027	7.895e-107	355.0	COG3618@1|root,COG3618@2|Bacteria,1R5V9@1224|Proteobacteria,2VSBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_4812499_3	864051.BurJ1DRAFT_2028	8.524e-161	517.0	COG3181@1|root,COG3181@2|Bacteria,1R81N@1224|Proteobacteria,2VMV6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_4812499_6	296591.Bpro_3370	6.123e-91	304.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VRYG@28216|Betaproteobacteria,4AEB8@80864|Comamonadaceae	28216|Betaproteobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HFD2_k127_4812499_9	388051.AUFE01000132_gene4943	1.183e-28	115.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2VP8A@28216|Betaproteobacteria,1K712@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hyfI	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HFD2_k127_4914461_7	983917.RGE_27610	1.182e-156	517.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,1KIXP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_4914461_11	420662.Mpe_A2002	2.234e-96	321.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1KK1G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD2_k127_4914461_9	987059.RBXJA2T_08048	1.894e-129	422.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,1KJ8M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_4914461_10	420662.Mpe_A2004	2.478e-101	349.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KK72@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HFD2_k127_4914461_1	420662.Mpe_A2005	9.969e-305	946.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,1KJVW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KL	HELICc2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HFD2_k127_4914461_12	420662.Mpe_A2006	5.576e-22	97.0	COG5481@1|root,COG5481@2|Bacteria,1NAQ6@1224|Proteobacteria,2VW3I@28216|Betaproteobacteria,1KMK5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HFD2_k127_4914461_8	420662.Mpe_A2007	2.081e-135	434.0	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,2VK9S@28216|Betaproteobacteria,1KJPH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HFD2_k127_4914461_13	1458275.AZ34_09180	8.393e-07	62.0	2DRUG@1|root,33D45@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4914461_4	1265502.KB905935_gene3076	1.507e-201	631.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,4AAAE@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM AFG1-family ATPase	yhcM	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HFD2_k127_4914461_2	420662.Mpe_A2010	5.474e-270	836.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1KJ4Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dehydrogenase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD2_k127_4914461_3	983917.RGE_27740	4.043e-219	686.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,1KIX4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_4914461_0	420662.Mpe_A2013	0.0	1785.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1KJXP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HFD2_k127_4914461_6	358220.C380_17270	1.495e-160	529.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2VH48@28216|Betaproteobacteria,4ABSG@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HFD2_k127_4914461_5	420662.Mpe_A1298	1.307e-189	597.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1KITG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_492874_1	987059.RBXJA2T_17841	1.544e-180	575.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KJ33@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HFD2_k127_492874_2	595537.Varpa_1057	1.448e-96	320.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2VI65@28216|Betaproteobacteria,4AB1X@80864|Comamonadaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	gst8	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_C_4,GST_N_3
HFD2_k127_492874_0	1380355.JNIJ01000018_gene4436	0.0	1379.0	COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JR6P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,CHASE3,DUF4118,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9
HFD2_k127_492874_3	1437824.BN940_07686	5.725e-05	48.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2W1GY@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,Response_reg
HFD2_k127_4941236_2	153721.MYP_4226	3.204e-63	221.0	COG0288@1|root,COG0659@1|root,COG0288@2|Bacteria,COG0659@2|Bacteria,4NEJT@976|Bacteroidetes,47MBG@768503|Cytophagia	976|Bacteroidetes	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HFD2_k127_4941236_0	381666.H16_A1811	1.019e-102	344.0	2DR3S@1|root,33A1K@2|Bacteria,1QYKB@1224|Proteobacteria	1224|Proteobacteria	S	Sulphur transport	-	-	-	ko:K07112,ko:K19168	-	-	-	-	ko00000,ko02048	-	-	-	Sulf_transp
HFD2_k127_4941236_1	1288826.MSNKSG1_16116	6.019e-91	305.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RQAV@1236|Gammaproteobacteria,4669J@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	walR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_4941236_3	381666.H16_A1819	9.96e-57	220.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,2VHKW@28216|Betaproteobacteria,1JZRD@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_4943719_7	999611.KI421505_gene4121	4.666e-49	187.0	2DT1R@1|root,33IA4@2|Bacteria,1NI27@1224|Proteobacteria,2US4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
HFD2_k127_4943719_6	314264.ROS217_05614	3.594e-52	212.0	COG1652@1|root,COG1652@2|Bacteria,1NMFX@1224|Proteobacteria,2UPIZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4943719_1	420662.Mpe_A1807	6.28e-204	655.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,1KJJX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Aminotransferase	dapC	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_4943719_4	420662.Mpe_A1806	1.571e-149	476.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2VHUX@28216|Betaproteobacteria,1KJWR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HFD2_k127_4943719_2	420662.Mpe_A1805	1.113e-196	619.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,1KJ3V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	twitching motility protein	pilT2	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD2_k127_4943719_3	1538295.JY96_01570	3.717e-172	580.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,1KJN0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_4943719_5	420662.Mpe_A1803	3.983e-121	415.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,1KK6C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
HFD2_k127_4943719_0	987059.RBXJA2T_08385	3.644e-232	725.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,1KIZX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD2_k127_4962509_2	1286631.X805_18280	6.987e-170	538.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_4962509_4	395495.Lcho_3978	9.483e-88	309.0	COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,2VRCD@28216|Betaproteobacteria,1KKK4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0227)	yqiA	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	UPF0227
HFD2_k127_4962509_5	420662.Mpe_A0469	2.319e-22	97.0	2EMEQ@1|root,33F3I@2|Bacteria,1NGX3@1224|Proteobacteria,2VY0E@28216|Betaproteobacteria,1KMUE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_4962509_3	395495.Lcho_0528	8.945e-156	504.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,1KIUC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HFD2_k127_4962509_0	420662.Mpe_A0467	7.161e-216	679.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1KJ9W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD2_k127_4962509_1	420662.Mpe_A0466	2.816e-204	637.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1KJVQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HFD2_k127_4988529_4	887062.HGR_05701	1.45e-62	217.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,4A9UC@80864|Comamonadaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HFD2_k127_4988529_0	358220.C380_13150	1.248e-206	661.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,4AAMJ@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_4988529_5	85643.Tmz1t_0524	3.241e-30	137.0	COG3090@1|root,COG3090@2|Bacteria,1RKD5@1224|Proteobacteria,2VTRF@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter subunit DctQ family protein 5	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_4988529_3	296591.Bpro_1777	1.189e-118	403.0	COG1638@1|root,COG1638@2|Bacteria,1MVYB@1224|Proteobacteria,2VIQ9@28216|Betaproteobacteria,4AA41@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP dicarboxylate transporter- DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_4988529_1	296591.Bpro_1776	4.254e-121	394.0	COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,2VJUJ@28216|Betaproteobacteria,4AA6P@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the D-glutamate cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1445
HFD2_k127_4988529_2	296591.Bpro_1775	2.518e-119	391.0	COG0583@1|root,COG0583@2|Bacteria,1QU1H@1224|Proteobacteria,2VIC7@28216|Betaproteobacteria,4AE7Q@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5009041_7	1265502.KB905940_gene2999	2.003e-138	440.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,4AAYN@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase NAD-binding	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD2_k127_5009041_4	1265502.KB905940_gene2998	7.399e-223	699.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4AA4T@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_5009041_1	1286631.X805_35780	4.925e-315	974.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VH3R@28216|Betaproteobacteria,1KJXM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Acetyl-CoA dehydrogenase C-terminal like	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_5009041_13	358220.C380_13355	4.43e-06	59.0	2EVGE@1|root,33NWT@2|Bacteria,1NGBG@1224|Proteobacteria,2VZ1Y@28216|Betaproteobacteria,4AFTJ@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5009041_3	420662.Mpe_A1779	1.114e-249	787.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,2VP2M@28216|Betaproteobacteria,1KNAR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
HFD2_k127_5009041_9	983917.RGE_24420	2.496e-119	417.0	COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VH22@28216|Betaproteobacteria,1KKCH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	gno1	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_5009041_11	1286631.X805_35800	5.039e-52	187.0	COG2050@1|root,COG2050@2|Bacteria,1MYG1@1224|Proteobacteria,2VTQD@28216|Betaproteobacteria,1KM5T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_5009041_5	1265502.KB905940_gene2992	1.946e-173	550.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VIE7@28216|Betaproteobacteria,4AAQT@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HFD2_k127_5009041_2	1265502.KB905940_gene2991	7.835e-250	781.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VHMA@28216|Betaproteobacteria,4A9UE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HFD2_k127_5009041_10	420662.Mpe_A1783	2.892e-91	331.0	COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,2VJ3I@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HFD2_k127_5009041_8	420662.Mpe_A1784	3.383e-137	464.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2WGHU@28216|Betaproteobacteria,1KJIZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_5009041_12	864051.BurJ1DRAFT_4401	8.04e-52	200.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2VSC6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HFD2_k127_5009041_6	420662.Mpe_A1785	7.647e-172	563.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VIGJ@28216|Betaproteobacteria,1KJQP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HFD2_k127_5009041_0	420662.Mpe_A1792	0.0	1204.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,1KJ5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Likely ribonuclease with RNase H fold.	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HFD2_k127_5071235_7	1300345.LF41_3143	1.925e-47	174.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HFD2_k127_5071235_6	1121939.L861_01760	1.161e-51	197.0	COG2128@1|root,COG2128@2|Bacteria,1NDTM@1224|Proteobacteria	1224|Proteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_5071235_1	1122599.AUGR01000005_gene1973	9.53e-197	625.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,1XK8Z@135619|Oceanospirillales	135619|Oceanospirillales	E	Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HFD2_k127_5071235_0	1192124.LIG30_3324	3.932e-233	747.0	28HYV@1|root,2Z846@2|Bacteria,1MXJ9@1224|Proteobacteria,2W79W@28216|Betaproteobacteria,1KE5U@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5071235_2	314231.FP2506_16859	2.798e-166	532.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD2_k127_5071235_5	1267534.KB906754_gene3701	1.016e-92	326.0	COG0671@1|root,COG0671@2|Bacteria,3Y8DY@57723|Acidobacteria	2|Bacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,PAP2
HFD2_k127_5071235_3	1323663.AROI01000002_gene1024	4.641e-153	492.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HFD2_k127_5071235_4	59538.XP_005964232.1	3.109e-110	362.0	KOG2610@1|root,KOG2610@2759|Eukaryota,39173@33154|Opisthokonta,3B960@33208|Metazoa,3CUUJ@33213|Bilateria,4833V@7711|Chordata,48X8K@7742|Vertebrata,3JE2C@40674|Mammalia,4J4MA@91561|Cetartiodactyla	33208|Metazoa	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5082366_12	1123320.KB889741_gene5243	6.263e-35	148.0	COG1028@1|root,COG1028@2|Bacteria,2IB1P@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_5082366_17	1415780.JPOG01000001_gene3389	3.295e-17	93.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1X30Y@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5082366_13	595537.Varpa_2260	3.487e-34	151.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,4AFCW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_5082366_2	1003200.AXXA_22890	7.681e-222	696.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2VN35@28216|Betaproteobacteria,3T70Y@506|Alcaligenaceae	28216|Betaproteobacteria	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5082366_5	1349767.GJA_2686	7.471e-64	228.0	COG3832@1|root,COG3832@2|Bacteria,1RDMX@1224|Proteobacteria,2VRWE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_5082366_6	663610.JQKO01000003_gene1509	2.076e-56	200.0	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2U5A4@28211|Alphaproteobacteria,3NCWV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HFD2_k127_5082366_7	1198452.Jab_2c15100	1.389e-52	194.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD2_k127_5082366_15	1510531.JQJJ01000009_gene1122	1.47e-27	121.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3JYB5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD2_k127_5082366_4	614083.AWQR01000014_gene2430	3.035e-77	269.0	COG1192@1|root,COG1192@2|Bacteria,1R5SX@1224|Proteobacteria,2VPMM@28216|Betaproteobacteria,4ACKR@80864|Comamonadaceae	28216|Betaproteobacteria	D	ATPase MipZ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA
HFD2_k127_5082366_16	1123368.AUIS01000028_gene1299	1.453e-19	101.0	COG2771@1|root,COG2771@2|Bacteria,1P52Q@1224|Proteobacteria,1SU2B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD2_k127_5082366_1	543728.Vapar_1694	1.847e-251	784.0	COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,2VI62@28216|Betaproteobacteria,4AD2I@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD2_k127_5082366_9	522306.CAP2UW1_2739	1.752e-50	186.0	COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,2VU7D@28216|Betaproteobacteria,1KQW0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HFD2_k127_5082366_0	864051.BurJ1DRAFT_2085	2.817e-271	840.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHZI@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD2_k127_5082366_11	864051.BurJ1DRAFT_2084	7.328e-37	144.0	2E6D9@1|root,3310W@2|Bacteria,1N9Y9@1224|Proteobacteria,2VWRF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HFD2_k127_5082366_3	864051.BurJ1DRAFT_2083	1.098e-169	538.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,1KKBI@119065|unclassified Burkholderiales	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_15805	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_5082366_14	1502852.FG94_02794	2.372e-33	146.0	COG5662@1|root,COG5662@2|Bacteria,1PX19@1224|Proteobacteria,2WCJ6@28216|Betaproteobacteria,477RB@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5082366_8	1502852.FG94_02793	9.014e-51	190.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2WF6R@28216|Betaproteobacteria,478XE@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5093483_2	296591.Bpro_2205	1.025e-78	269.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VR36@28216|Betaproteobacteria,4AEK9@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_5093483_4	1268622.AVS7_03394	9.796e-40	162.0	COG3203@1|root,COG3203@2|Bacteria,1R5T2@1224|Proteobacteria,2VMH6@28216|Betaproteobacteria,4ACZH@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM porin Gram-negative type	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_5093483_5	420662.Mpe_A2233	3.317e-36	146.0	COG3672@1|root,COG3672@2|Bacteria	2|Bacteria	O	Periplasmic Protein	MA20_31720	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HFD2_k127_5093483_6	864051.BurJ1DRAFT_4398	6.039e-28	121.0	2E4XG@1|root,32ZRD@2|Bacteria,1N79W@1224|Proteobacteria,2VWJP@28216|Betaproteobacteria,1KMGN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	tryptophan synthase subunit beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5093483_0	1268622.AVS7_03843	8.23e-140	452.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4AA2A@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_5093483_3	358220.C380_22185	2.239e-69	254.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,2VMJB@28216|Betaproteobacteria,4AH28@80864|Comamonadaceae	28216|Betaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD2_k127_5093483_1	1223521.BBJX01000001_gene1018	6.14e-100	340.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2VN5V@28216|Betaproteobacteria,4AB62@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5093483_7	1156919.QWC_13762	1.65e-23	102.0	COG1437@1|root,COG1437@2|Bacteria,1RJYE@1224|Proteobacteria,2VT6N@28216|Betaproteobacteria,3T7NJ@506|Alcaligenaceae	28216|Betaproteobacteria	F	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CYTH
HFD2_k127_509373_11	420662.Mpe_A2088	1.329e-101	337.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KJN7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HFD2_k127_509373_9	1198452.Jab_1c22300	4.655e-142	467.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,475U7@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
HFD2_k127_509373_15	765911.Thivi_1320	1.972e-61	222.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,1T3XH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Pfam Response regulator receiver	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Response_reg
HFD2_k127_509373_0	395495.Lcho_2900	8.019e-318	979.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1KIX7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HFD2_k127_509373_12	349163.Acry_1699	2.838e-82	297.0	COG3210@1|root,COG3210@2|Bacteria,1R8FI@1224|Proteobacteria,2U2G1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_509373_1	1265502.KB905932_gene1856	4.338e-285	903.0	COG2186@1|root,COG2186@2|Bacteria,1QZYM@1224|Proteobacteria,2VI66@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
HFD2_k127_509373_2	420662.Mpe_A2217	2.069e-276	885.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VIVH@28216|Betaproteobacteria,1KJKC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
HFD2_k127_509373_4	420662.Mpe_A2216	1.57e-191	612.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1KMR3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_509373_6	864051.BurJ1DRAFT_3738	3.529e-176	569.0	COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,1KKCI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD2_k127_509373_16	398579.Spea_3950	6.36e-33	142.0	2B9C3@1|root,322PT@2|Bacteria,1NTUZ@1224|Proteobacteria,1SMH9@1236|Gammaproteobacteria,2QBH3@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_509373_10	987059.RBXJA2T_11987	4.639e-114	372.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1KPKI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	qseB	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_509373_7	987059.RBXJA2T_11992	3.825e-160	527.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,1KPCK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	qseC	-	2.7.13.3	ko:K02484,ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_509373_13	1523503.JPMY01000036_gene1493	1.187e-71	245.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,1S69N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_509373_14	215803.DB30_8197	1.731e-61	222.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,43AIC@68525|delta/epsilon subdivisions,2X9TN@28221|Deltaproteobacteria,2YV16@29|Myxococcales	28221|Deltaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_509373_5	948106.AWZT01000018_gene4737	3.815e-189	600.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2VKYD@28216|Betaproteobacteria,1K58P@119060|Burkholderiaceae	28216|Betaproteobacteria	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_509373_3	395495.Lcho_0274	7.571e-214	697.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1KIXK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_509373_17	1121127.JAFA01000041_gene4347	9.148e-15	87.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,2VVVI@28216|Betaproteobacteria,1K41M@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD2_k127_509373_8	1265502.KB905934_gene3237	1.064e-151	482.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,4ACUT@80864|Comamonadaceae	28216|Betaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HFD2_k127_5139496_5	1265502.KB905969_gene1230	2.009e-28	126.0	2C73B@1|root,330Z7@2|Bacteria,1N4FW@1224|Proteobacteria,2W6GV@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5139496_6	1100721.ALKO01000003_gene1979	2.057e-25	112.0	2EHAV@1|root,33B2Q@2|Bacteria,1NN39@1224|Proteobacteria,2VYPQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5139496_1	395495.Lcho_3019	1.676e-83	292.0	2BXSN@1|root,32R1X@2|Bacteria,1MYVK@1224|Proteobacteria,2VYN9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF4243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4243
HFD2_k127_5139496_2	1211115.ALIQ01000190_gene914	8.029e-73	262.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,3NBUK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5139496_7	1134474.O59_002808	4.507e-15	86.0	2BY18@1|root,331KN@2|Bacteria,1N85J@1224|Proteobacteria,1SFND@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5139496_0	395495.Lcho_1848	2.756e-184	593.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2VMTR@28216|Betaproteobacteria,1KK4F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Murein transglycosylase	mltB_1	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
HFD2_k127_5139496_3	864051.BurJ1DRAFT_1876	2.731e-46	179.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VSFR@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HFD2_k127_5139496_4	159087.Daro_2711	5.868e-42	157.0	COG0810@1|root,COG1193@1|root,COG3064@1|root,COG0810@2|Bacteria,COG1193@2|Bacteria,COG3064@2|Bacteria,1REKC@1224|Proteobacteria,2VRYT@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
HFD2_k127_5150278_0	987059.RBXJA2T_07623	1.614e-256	799.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KJPX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_5150278_1	864051.BurJ1DRAFT_4996	2.134e-237	752.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KKIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_5150278_2	987059.RBXJA2T_07628	2.661e-229	744.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KKIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD2_k127_5150278_3	1265502.KB905974_gene579	2.46e-96	322.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,4ABH0@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_5200287_4	543913.D521_0543	2.001e-39	151.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,1KR0V@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
HFD2_k127_5200287_3	1123393.KB891316_gene2078	5.375e-54	202.0	COG4313@1|root,COG4313@2|Bacteria,1R5Z9@1224|Proteobacteria,2VKTG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD2_k127_5200287_2	864051.BurJ1DRAFT_4500	4.918e-93	308.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,1KJKB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HFD2_k127_5200287_1	864051.BurJ1DRAFT_4499	6.276e-108	355.0	COG2197@1|root,COG2197@2|Bacteria,1RGXD@1224|Proteobacteria,2WEGP@28216|Betaproteobacteria,1KIYQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_5200287_0	420662.Mpe_A3238	6.257e-195	623.0	COG4585@1|root,COG4585@2|Bacteria,1R1TC@1224|Proteobacteria,2VHUA@28216|Betaproteobacteria,1KIW1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA_3
HFD2_k127_522888_3	420662.Mpe_A3516	5.219e-36	138.0	COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2VKX4@28216|Betaproteobacteria,1KJ03@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD2	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
HFD2_k127_522888_0	1265502.KB905951_gene826	1.205e-89	299.0	COG1309@1|root,COG1309@2|Bacteria,1P4J2@1224|Proteobacteria,2VHWF@28216|Betaproteobacteria,4ABFR@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_522888_2	395495.Lcho_0944	7.546e-52	187.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,1KM2Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_522888_4	159450.NH14_00955	9.417e-35	143.0	COG2885@1|root,COG2885@2|Bacteria,1PE9J@1224|Proteobacteria,2VU1Y@28216|Betaproteobacteria,1KDE8@119060|Burkholderiaceae	28216|Betaproteobacteria	N	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_522888_1	768670.Calni_0859	5.59e-70	267.0	COG1520@1|root,COG3391@1|root,COG4249@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_NS,Peptidase_C14,WD40
HFD2_k127_526916_6	1235457.C404_24965	8.058e-85	286.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,1K3GI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	4-Hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HFD2_k127_526916_7	296591.Bpro_4212	8.69e-78	262.0	COG1522@1|root,COG1522@2|Bacteria,1QSAH@1224|Proteobacteria,2WFK0@28216|Betaproteobacteria,4AANS@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_526916_4	338969.Rfer_4086	2.361e-101	337.0	COG1639@1|root,COG1639@2|Bacteria,1R4ZN@1224|Proteobacteria,2VQ1P@28216|Betaproteobacteria,4ADH3@80864|Comamonadaceae	28216|Betaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
HFD2_k127_526916_1	420662.Mpe_A3687	2.363e-147	488.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2VI0Z@28216|Betaproteobacteria,1KKQQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_526916_5	543728.Vapar_5134	5.227e-93	330.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,4AD1K@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_526916_10	1444310.JANV01000035_gene532	9.615e-59	226.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,1ZCC8@1386|Bacillus	91061|Bacilli	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
HFD2_k127_526916_0	864051.BurJ1DRAFT_1799	1.708e-152	492.0	COG0604@1|root,COG0604@2|Bacteria,1QUNT@1224|Proteobacteria,2VM3W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Protein of unknown function (DUF2855)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2855
HFD2_k127_526916_3	864051.BurJ1DRAFT_0484	6.095e-112	368.0	COG0656@1|root,COG0656@2|Bacteria,1MUH2@1224|Proteobacteria,2VJNQ@28216|Betaproteobacteria,1KMZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Aldo/keto reductase family	-	-	1.1.1.21	ko:K00011	ko00040,ko00051,ko00052,ko00561,ko00790,ko01100,map00040,map00051,map00052,map00561,map00790,map01100	-	R01036,R01041,R01093,R01095,R01431,R01758,R01759,R01787,R02531,R02577,R04285,R11764	RC00099,RC00108,RC00133,RC00205,RC00670	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_526916_9	864051.BurJ1DRAFT_0483	1.807e-61	239.0	2CI4X@1|root,33KFB@2|Bacteria,1NMX9@1224|Proteobacteria,2VXT3@28216|Betaproteobacteria,1KMSX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_526916_8	264198.Reut_A1800	1.783e-76	274.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1K1VT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
HFD2_k127_526916_2	296591.Bpro_0635	5.913e-131	420.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,4ACI6@80864|Comamonadaceae	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
HFD2_k127_526916_11	596153.Alide_1353	1.471e-11	65.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2WG03@28216|Betaproteobacteria,4AJU8@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD2_k127_5283110_0	1286631.X805_18840	6.333e-161	509.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,1KJDH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_5283110_1	264198.Reut_A0370	1.023e-84	303.0	2ECI6@1|root,32W6D@2|Bacteria,1N4WJ@1224|Proteobacteria,2VVDB@28216|Betaproteobacteria,1K5V4@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5283110_3	667632.KB890165_gene2564	1.887e-48	188.0	COG2199@1|root,COG3706@2|Bacteria,1NEHB@1224|Proteobacteria,2W2SA@28216|Betaproteobacteria	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_5283110_2	713586.KB900536_gene2437	9.573e-71	251.0	COG0642@1|root,COG0784@1|root,COG3614@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg
HFD2_k127_5329413_6	232721.Ajs_0445	7.125e-40	155.0	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,2VUY4@28216|Betaproteobacteria,4AE71@80864|Comamonadaceae	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_5329413_1	1265502.KB905946_gene1147	1.506e-183	588.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,4AAG9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HFD2_k127_5329413_7	395495.Lcho_0249	8.915e-36	141.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VT97@28216|Betaproteobacteria,1KM75@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5329413_8	85643.Tmz1t_4011	7.68e-18	89.0	COG1145@1|root,COG1145@2|Bacteria,1N09Y@1224|Proteobacteria,2VSKG@28216|Betaproteobacteria,2KWRK@206389|Rhodocyclales	206389|Rhodocyclales	C	ferredoxin-type protein napF	-	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4_7,Fer4_9
HFD2_k127_5329413_4	864051.BurJ1DRAFT_0536	6.043e-110	358.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VMSB@28216|Betaproteobacteria,1KPBQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM NapC NirT cytochrome c	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
HFD2_k127_5329413_5	395495.Lcho_1340	5.637e-68	235.0	COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2VTPE@28216|Betaproteobacteria,1KNJ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
HFD2_k127_5329413_2	395495.Lcho_1341	4.88e-142	469.0	COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJYI@28216|Betaproteobacteria,1KMXQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM ferredoxin-type protein, NapH MauN family	napH	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4_10,Fer4_5,Fer4_6,Fer4_7,Fer4_9
HFD2_k127_5329413_3	864051.BurJ1DRAFT_0539	3.927e-128	415.0	COG0437@1|root,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,2VKT4@28216|Betaproteobacteria,1KMXN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM MauM NapG family ferredoxin-type protein	napG	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_3,Fer4_4,Fer4_7
HFD2_k127_5329413_0	864051.BurJ1DRAFT_0540	6.929e-221	686.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KN24@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC	napA	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_5347357_6	1238190.AMQY01000011_gene2041	1.345e-26	110.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1XK0T@135619|Oceanospirillales	135619|Oceanospirillales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
HFD2_k127_5347357_0	1538295.JY96_15250	8.425e-224	707.0	COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VH5V@28216|Betaproteobacteria,1KN1F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	NMT1-like family	ssuA1	-	-	ko:K15553	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.2	-	-	NMT1,NMT1_2
HFD2_k127_5347357_4	1538295.JY96_15245	9.477e-108	359.0	COG0600@1|root,COG0600@2|Bacteria,1MV2D@1224|Proteobacteria,2VI6N@28216|Betaproteobacteria,1KNT4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD2_k127_5347357_2	1538295.JY96_15240	1.564e-121	411.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,1KNA5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD2_k127_5347357_7	1198452.Jab_1c14650	4.7e-15	87.0	COG3536@1|root,COG3536@2|Bacteria,1NICI@1224|Proteobacteria,2VYG4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HFD2_k127_5347357_1	522306.CAP2UW1_2717	9.788e-125	406.0	COG0543@1|root,COG0543@2|Bacteria,1QTSK@1224|Proteobacteria,2VH0M@28216|Betaproteobacteria,1KR9F@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Oxidoreductase NAD-binding domain	fpr	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
HFD2_k127_5347357_3	398578.Daci_1990	7.529e-110	365.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2VPD9@28216|Betaproteobacteria,4ADRD@80864|Comamonadaceae	28216|Betaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HFD2_k127_5347357_5	859657.RPSI07_1923	9.094e-53	189.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2VHXT@28216|Betaproteobacteria,1K3UK@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_5355957_6	1379270.AUXF01000004_gene2919	1.892e-90	326.0	COG0515@1|root,COG0515@2|Bacteria,1ZUF3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_5355957_10	1176165.CAJD01000022_gene1769	0.0002643	43.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4FARV@85019|Brevibacteriaceae	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD2_k127_5355957_4	420662.Mpe_A1349	8.461e-103	343.0	COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,2VJPP@28216|Betaproteobacteria,1KJ41@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ThiF family	moeB	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
HFD2_k127_5355957_2	1265502.KB905929_gene2242	4.663e-152	488.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,4ABCJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD2_k127_5355957_5	420662.Mpe_A1348	3.898e-93	316.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,1KK9M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
HFD2_k127_5355957_9	420662.Mpe_A1347	1.913e-54	197.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,1KM0B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD2_k127_5355957_1	420662.Mpe_A1346	5.845e-201	637.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,1KJYN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD2_k127_5355957_7	1286631.X805_10360	1.735e-83	288.0	COG1216@1|root,COG1216@2|Bacteria,1QU2Q@1224|Proteobacteria,2WGZN@28216|Betaproteobacteria,1KPMW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HFD2_k127_5355957_0	864051.BurJ1DRAFT_1999	6.43e-237	745.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ0P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD2_k127_5355957_3	338969.Rfer_2083	1.613e-121	423.0	2C9BY@1|root,32IIJ@2|Bacteria,1MYQZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5355957_8	266264.Rmet_0758	1.345e-78	283.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,1JZUC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_5362011_0	420662.Mpe_A3070	7.269e-159	507.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,1KKBK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
HFD2_k127_5362011_2	420662.Mpe_A3069	1.517e-109	358.0	COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,2VISC@28216|Betaproteobacteria,1KIXM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar basal-body rod protein FlgF	flgF	-	-	ko:K02391	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD2_k127_5362011_5	1120949.KB903316_gene62	3.436e-32	132.0	2DX9S@1|root,3441J@2|Bacteria,2IT0X@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD2_k127_5362011_1	420662.Mpe_A3068	1.003e-126	413.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2VH7A@28216|Betaproteobacteria,1KJ3E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	flagellar basal-body rod protein	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HFD2_k127_5362011_3	420662.Mpe_A3067	2.644e-81	289.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2VRIC@28216|Betaproteobacteria,1KJYH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
HFD2_k127_5362011_4	1265502.KB905929_gene2182	1.643e-74	253.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2VJAZ@28216|Betaproteobacteria,4AAPV@80864|Comamonadaceae	28216|Betaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
HFD2_k127_5362295_21	864051.BurJ1DRAFT_1299	1.706e-48	183.0	COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,1KMEJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
HFD2_k127_5362295_2	420662.Mpe_A1065	1.548e-227	711.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VH0H@28216|Betaproteobacteria,1KJF1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	TIGRFAM Undecaprenyl-phosphate glucose phosphotransferase	wcaJ	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
HFD2_k127_5362295_17	420662.Mpe_A1064	8.657e-82	287.0	COG5338@1|root,COG5338@2|Bacteria,1RG4R@1224|Proteobacteria,2VRGR@28216|Betaproteobacteria,1KM08@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5362295_6	1265502.KB905942_gene2811	1.173e-156	500.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,4ACP5@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD2_k127_5362295_3	864051.BurJ1DRAFT_1295	4.528e-217	689.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,1KIYW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD2_k127_5362295_5	76114.ebA1639	6.072e-173	572.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUD6@206389|Rhodocyclales	206389|Rhodocyclales	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD2_k127_5362295_1	497321.C664_14629	2.485e-230	717.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,2KUVI@206389|Rhodocyclales	206389|Rhodocyclales	M	UDP binding domain	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD2_k127_5362295_14	1095769.CAHF01000011_gene2019	1.401e-95	319.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria,472EY@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the glycosyltransferase 26 family	tagA	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,STAS_2
HFD2_k127_5362295_8	864051.BurJ1DRAFT_1284	6.391e-139	468.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2VKTV@28216|Betaproteobacteria,1KJ7H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_5362295_11	983917.RGE_10810	2.115e-113	379.0	COG0438@1|root,COG0438@2|Bacteria,1PBQ3@1224|Proteobacteria,2VM7R@28216|Betaproteobacteria,1KMWJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD2_k127_5362295_0	983917.RGE_10820	2.627e-262	831.0	COG3693@1|root,COG3693@2|Bacteria,1QXZM@1224|Proteobacteria	1224|Proteobacteria	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_cc
HFD2_k127_5362295_10	1121033.AUCF01000004_gene4964	3.018e-120	414.0	COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria,2V6ZD@28211|Alphaproteobacteria,2JRTZ@204441|Rhodospirillales	204441|Rhodospirillales	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
HFD2_k127_5362295_24	1121033.AUCF01000004_gene4962	6.164e-20	98.0	COG3474@1|root,COG3474@2|Bacteria,1RGSY@1224|Proteobacteria,2U84R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD2_k127_5362295_22	1408418.JNJH01000004_gene1929	5.236e-45	177.0	COG1835@1|root,COG1835@2|Bacteria,1R2GK@1224|Proteobacteria,2TZK4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HFD2_k127_5362295_13	983917.RGE_10790	2.489e-101	344.0	2CFSE@1|root,33P87@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5362295_9	983917.RGE_10780	4.303e-131	442.0	COG3664@1|root,COG3664@2|Bacteria,1MX9Q@1224|Proteobacteria,2W20Q@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5362295_15	498848.TaqDRAFT_3465	1.96e-85	303.0	COG0438@1|root,COG0438@2|Bacteria,1WIBN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyltransferase Family 4	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_5362295_23	395495.Lcho_2343	1.745e-35	157.0	COG0438@1|root,COG0438@2|Bacteria,1PFR8@1224|Proteobacteria,2W932@28216|Betaproteobacteria,1KP8S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5362295_16	420662.Mpe_A0730	2.278e-84	299.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2VU4H@28216|Betaproteobacteria,1KMSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328,ko:K16694	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.6	-	-	Polysacc_synt_3,Polysacc_synt_C
HFD2_k127_5362295_7	864051.BurJ1DRAFT_1271	6.988e-154	491.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2VK2N@28216|Betaproteobacteria,1KIT7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD2_k127_5362295_18	1123393.KB891316_gene1093	9.352e-81	274.0	COG2227@1|root,COG2227@2|Bacteria,1R2PD@1224|Proteobacteria,2VT6X@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD2_k127_5362295_4	1538295.JY96_15605	7.813e-204	652.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,1KJP0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HFD2_k127_5362295_20	983917.RGE_10740	1.601e-63	236.0	2DKYH@1|root,30WKQ@2|Bacteria,1RCXC@1224|Proteobacteria,2VR6P@28216|Betaproteobacteria,1KM2S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485
HFD2_k127_5362295_12	983917.RGE_10730	5.477e-109	363.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria,1KJHI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HFD2_k127_5362295_19	864051.BurJ1DRAFT_1267	1.024e-69	239.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VN0C@28216|Betaproteobacteria,1KJ2W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CbiA,GNVR,Wzz
HFD2_k127_5383497_5	103733.JNYO01000039_gene4484	9.549e-30	133.0	COG2885@1|root,COG2885@2|Bacteria,2IBAR@201174|Actinobacteria,4E6AA@85010|Pseudonocardiales	201174|Actinobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5383497_4	258533.BN977_05187	2.577e-65	255.0	2C8BF@1|root,33QMI@2|Bacteria,2IH1Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5383497_1	543728.Vapar_3345	7.567e-200	626.0	COG1879@1|root,COG1879@2|Bacteria,1MUJU@1224|Proteobacteria,2VJED@28216|Betaproteobacteria,4AGNK@80864|Comamonadaceae	28216|Betaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_5383497_2	1157708.KB907465_gene299	1.351e-183	581.0	COG1172@1|root,COG1172@2|Bacteria,1MVXA@1224|Proteobacteria,2VMXY@28216|Betaproteobacteria,4AHAW@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HFD2_k127_5383497_0	595537.Varpa_2274	1.314e-236	744.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VK2Z@28216|Betaproteobacteria,4AGHD@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM ABC transporter related	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HFD2_k127_5383497_3	595537.Varpa_2275	2.318e-98	323.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2VK61@28216|Betaproteobacteria,4ABNM@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase LRE domain protein	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_5395212_4	1163407.UU7_09330	0.0001233	46.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg,dCache_1
HFD2_k127_5395212_1	983917.RGE_04900	5.316e-122	399.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KJ0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HFD2_k127_5395212_0	420662.Mpe_A3295	1.576e-264	833.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,1KJ7Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lytic transglycosylase catalytic	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
HFD2_k127_5395212_2	1265502.KB905960_gene303	3.781e-53	194.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,4AC4U@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD2_k127_5395212_3	365044.Pnap_0529	3.062e-13	70.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,4AARE@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5448743_9	983917.RGE_00530	3.124e-76	260.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,1KKKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	regulatory protein Crp	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_5448743_12	338969.Rfer_0021	6.623e-25	106.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,4AFBH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HFD2_k127_5448743_5	83406.HDN1F_07040	3.34e-94	314.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,1JANE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein family UPF0016	HA62_23750	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HFD2_k127_5448743_15	457429.ABJI02000676_gene2003	0.0001007	50.0	2B33I@1|root,2ZJBV@2|Bacteria,2GW38@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5448743_14	9593.ENSGGOP00000017139	1.91e-09	70.0	KOG1565@1|root,KOG1565@2759|Eukaryota,38HNS@33154|Opisthokonta,3BHFC@33208|Metazoa,3D46K@33213|Bilateria,485QT@7711|Chordata,49107@7742|Vertebrata,3J1S8@40674|Mammalia,35B2H@314146|Euarchontoglires,4MCGV@9443|Primates,4MS1Z@9604|Hominidae	33208|Metazoa	OW	Matrix metallopeptidase 12	MMP12	GO:0000122,GO:0001047,GO:0001067,GO:0001666,GO:0001817,GO:0001819,GO:0001959,GO:0001960,GO:0001961,GO:0002009,GO:0002011,GO:0002682,GO:0002683,GO:0002684,GO:0002697,GO:0002791,GO:0002793,GO:0002831,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005488,GO:0005509,GO:0005518,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0006508,GO:0006606,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006928,GO:0006950,GO:0008104,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0008270,GO:0008284,GO:0009056,GO:0009605,GO:0009607,GO:0009611,GO:0009615,GO:0009628,GO:0009653,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0014070,GO:0015031,GO:0015833,GO:0016043,GO:0016477,GO:0016787,GO:0017038,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0022411,GO:0022617,GO:0023051,GO:0023056,GO:0023057,GO:0030198,GO:0030334,GO:0030574,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031347,GO:0031348,GO:0031349,GO:0032101,GO:0032479,GO:0032481,GO:0032502,GO:0032647,GO:0032727,GO:0032879,GO:0032880,GO:0032963,GO:0033036,GO:0033365,GO:0034504,GO:0034613,GO:0035313,GO:0036293,GO:0040011,GO:0040012,GO:0042060,GO:0042127,GO:0042221,GO:0042493,GO:0042886,GO:0043062,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043565,GO:0043900,GO:0044212,GO:0044238,GO:0044319,GO:0044421,GO:0044424,GO:0044464,GO:0044877,GO:0045088,GO:0045089,GO:0045184,GO:0045824,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046872,GO:0046907,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048729,GO:0048856,GO:0048870,GO:0050678,GO:0050679,GO:0050688,GO:0050691,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051169,GO:0051170,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051254,GO:0051270,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051707,GO:0060054,GO:0060255,GO:0060338,GO:0060339,GO:0060340,GO:0060429,GO:0060759,GO:0060760,GO:0060761,GO:0065007,GO:0070011,GO:0070201,GO:0070482,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0080090,GO:0080134,GO:0090087,GO:0090504,GO:0090505,GO:0097159,GO:0098586,GO:0140096,GO:1901163,GO:1901363,GO:1901564,GO:1902679,GO:1902680,GO:1902739,GO:1902741,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1903532,GO:1904951,GO:2000026,GO:2000112,GO:2000113,GO:2000145,GO:2000241,GO:2001141	3.4.24.17,3.4.24.22,3.4.24.34,3.4.24.65,3.4.24.7,3.4.24.80	ko:K01388,ko:K01394,ko:K01396,ko:K01402,ko:K01413,ko:K07763,ko:K07994,ko:K07999	ko03320,ko04657,ko04668,ko04912,ko04926,ko05200,ko05202,ko05215,ko05219,ko05323,map03320,map04657,map04668,map04912,map04926,map05200,map05202,map05215,map05219,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04516	-	-	-	Hemopexin,PG_binding_1,Peptidase_M10
HFD2_k127_5448743_4	663610.JQKO01000001_gene736	6.292e-149	478.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,3NA6C@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5448743_0	420662.Mpe_A2061	4.826e-296	940.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,1KK4U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase	phbC2	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HFD2_k127_5448743_3	1123504.JQKD01000015_gene961	7.968e-152	519.0	COG1541@1|root,COG1541@2|Bacteria,1P22K@1224|Proteobacteria,2WGC2@28216|Betaproteobacteria,4ACC7@80864|Comamonadaceae	28216|Betaproteobacteria	H	coenzyme F390 synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HFD2_k127_5448743_7	395495.Lcho_0901	3.533e-88	295.0	COG2197@1|root,COG2197@2|Bacteria,1RENN@1224|Proteobacteria,2VR4J@28216|Betaproteobacteria,1KM8B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_5448743_2	420662.Mpe_A2066	7.728e-164	530.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria,1KJYZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HFD2_k127_5448743_11	864051.BurJ1DRAFT_4022	2.084e-25	114.0	COG4565@1|root,COG4565@2|Bacteria	2|Bacteria	KT	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,HTH_8,PAS_4,Response_reg,Sigma54_activat,SpoIIE
HFD2_k127_5448743_6	864051.BurJ1DRAFT_4023	2.078e-90	327.0	COG2972@1|root,COG3290@1|root,COG4585@1|root,COG2972@2|Bacteria,COG3290@2|Bacteria,COG4585@2|Bacteria,1R43J@1224|Proteobacteria,2VPEB@28216|Betaproteobacteria,1KMD2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	histidine kinase dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K02486	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HFD2_k127_5448743_10	338969.Rfer_3850	4.07e-37	145.0	COG2905@1|root,COG2905@2|Bacteria,1QVY2@1224|Proteobacteria,2VT7K@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD2_k127_5448743_1	365044.Pnap_0389	1.785e-261	818.0	COG0459@1|root,COG0459@2|Bacteria,1NRHG@1224|Proteobacteria,2W0NW@28216|Betaproteobacteria,4AH8I@80864|Comamonadaceae	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	-	-	-	-	-	-	-	-	-	Cpn60_TCP1
HFD2_k127_5448743_8	395495.Lcho_0903	3.588e-86	294.0	COG0664@1|root,COG0664@2|Bacteria,1RIZ0@1224|Proteobacteria,2VSK2@28216|Betaproteobacteria,1KNGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_5448743_13	296591.Bpro_1168	1.926e-23	100.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VTUB@28216|Betaproteobacteria,4AHWC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5467536_8	296591.Bpro_0130	1.133e-123	404.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VHHF@28216|Betaproteobacteria,4AES6@80864|Comamonadaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
HFD2_k127_5467536_2	296591.Bpro_0131	2.926e-219	688.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2VJJ3@28216|Betaproteobacteria,4AAA4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HFD2_k127_5467536_14	296591.Bpro_0132	2.283e-104	366.0	COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,2VMQ1@28216|Betaproteobacteria,4AEMT@80864|Comamonadaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD2_k127_5467536_0	296591.Bpro_0133	0.0	1189.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,4AAUA@80864|Comamonadaceae	28216|Betaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HFD2_k127_5467536_19	595537.Varpa_5622	2.979e-52	199.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VJSB@28216|Betaproteobacteria,4AGR7@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_5467536_1	420662.Mpe_A1248	1.159e-264	835.0	COG4585@1|root,COG4585@2|Bacteria,1R8DN@1224|Proteobacteria,2VPJ9@28216|Betaproteobacteria,1KKHD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD2_k127_5467536_10	864051.BurJ1DRAFT_2442	1.101e-122	396.0	COG2197@1|root,COG2197@2|Bacteria,1Q7GF@1224|Proteobacteria,2VN5C@28216|Betaproteobacteria,1KKI8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_5467536_4	1265502.KB905929_gene2299	7.461e-161	534.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,4A9W7@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5467536_11	987059.RBXJA2T_09622	6.992e-114	400.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,1KJMJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD2_k127_5467536_17	983917.RGE_33350	1.696e-93	329.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,1KK61@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_5467536_13	864051.BurJ1DRAFT_2446	4.267e-111	368.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,1KITX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	DM	peptidase	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
HFD2_k127_5467536_6	420662.Mpe_A1255	1.372e-136	442.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,2VIUT@28216|Betaproteobacteria,1KK1Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	RNA polymerase sigma	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD2_k127_5467536_3	864051.BurJ1DRAFT_2640	2.512e-203	643.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,1KK6J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	gbd1	-	1.1.1.61,1.3.1.32	ko:K00043,ko:K00217	ko00361,ko00362,ko00364,ko00623,ko00650,ko01100,ko01120,ko01200,ko01220,map00361,map00362,map00364,map00623,map00650,map01100,map01120,map01200,map01220	-	R01644,R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00087,RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HFD2_k127_5467536_7	983917.RGE_26140	1.155e-126	413.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VJSB@28216|Betaproteobacteria,1KK3F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_5467536_9	1265502.KB905940_gene2983	5.467e-123	409.0	COG0824@1|root,COG2153@1|root,COG0824@2|Bacteria,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,4A9NN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase superfamily protein	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
HFD2_k127_5467536_12	420662.Mpe_A1864	1.259e-113	379.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,1KJ3H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HFD2_k127_5467536_16	983917.RGE_26110	5.162e-96	323.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1KJWV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HFD2_k127_5467536_5	420662.Mpe_A1861	2.147e-155	513.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1KJYW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD2_k127_5467536_18	395495.Lcho_1878	7.616e-61	215.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2VQ24@28216|Betaproteobacteria,1KKNX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD2_k127_5467536_15	420662.Mpe_A1859	1.754e-99	341.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,1KJ9P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HFD2_k127_5501191_1	1100721.ALKO01000022_gene1917	4.404e-158	504.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2VMEP@28216|Betaproteobacteria,4AAKK@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_5501191_8	296591.Bpro_4497	4.624e-71	246.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,4ADHC@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HFD2_k127_5501191_5	395495.Lcho_3684	3.233e-97	323.0	COG1414@1|root,COG1414@2|Bacteria,1N957@1224|Proteobacteria,2VN36@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator IclR	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_5501191_0	748247.AZKH_p0479	2.342e-249	779.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHKK@28216|Betaproteobacteria,2KW0D@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HFD2_k127_5501191_4	1458357.BG58_31930	2.896e-135	436.0	COG0169@1|root,COG0169@2|Bacteria,1MVW5@1224|Proteobacteria,2VJU3@28216|Betaproteobacteria,1K4DF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Shikimate dehydrogenase substrate binding domain	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N,ThiF
HFD2_k127_5501191_3	296591.Bpro_1853	4.272e-138	444.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VHYD@28216|Betaproteobacteria,4ACG3@80864|Comamonadaceae	28216|Betaproteobacteria	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HFD2_k127_5501191_2	1265502.KB905929_gene2244	1.118e-143	480.0	COG1082@1|root,COG1082@2|Bacteria,1QYE4@1224|Proteobacteria,2VJQ6@28216|Betaproteobacteria,4ABF5@80864|Comamonadaceae	28216|Betaproteobacteria	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HFD2_k127_5501191_7	1040989.AWZU01000001_gene5768	2.994e-81	301.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2TSFB@28211|Alphaproteobacteria,3JRCB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1501)	MA20_05265	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_5501191_6	626418.bglu_2g19220	7.332e-97	334.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJ7P@28216|Betaproteobacteria,1JZP6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_5509771_1	395495.Lcho_3013	3.737e-165	524.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VK5J@28216|Betaproteobacteria,1KJPS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Metallophos
HFD2_k127_5509771_3	1286631.X805_08120	2.325e-13	72.0	2ERQ5@1|root,33J9H@2|Bacteria,1NH00@1224|Proteobacteria,2VYJU@28216|Betaproteobacteria,1KMTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5509771_2	420662.Mpe_A0018	4.576e-115	377.0	COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2VKMF@28216|Betaproteobacteria,1KM4G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Formate/nitrite transporter	-	-	-	ko:K02598,ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.3	-	-	Form_Nir_trans
HFD2_k127_5509771_0	395495.Lcho_3854	8.44e-201	646.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1KITF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_5525756_2	420662.Mpe_A1120	5.835e-129	421.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,1KKCX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD2_k127_5525756_4	365046.Rta_12030	3.348e-85	290.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2VQFX@28216|Betaproteobacteria,4ADV4@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HFD2_k127_5525756_1	395495.Lcho_2528	1.912e-140	469.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MUAK@1224|Proteobacteria,2VIS3@28216|Betaproteobacteria,1KJD7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_5525756_3	395495.Lcho_2529	6.366e-102	335.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VIYR@28216|Betaproteobacteria,1KKCK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_5525756_6	365044.Pnap_2741	2.265e-36	153.0	2DHD4@1|root,32U92@2|Bacteria,1N29H@1224|Proteobacteria,2VU9F@28216|Betaproteobacteria,4AEY8@80864|Comamonadaceae	28216|Betaproteobacteria	S	LTXXQ motif family protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
HFD2_k127_5525756_0	420662.Mpe_A3493	2.434e-216	691.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,1KJC5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HFD2_k127_5525756_5	420662.Mpe_A3492	2.013e-59	224.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,1KIWX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HFD2_k127_5532686_2	983917.RGE_43320	1.731e-228	717.0	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,1KNCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	LT	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_5532686_7	395495.Lcho_2160	4.627e-55	197.0	2E43S@1|root,32Z03@2|Bacteria,1NB33@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5532686_0	983917.RGE_43310	8.893e-306	945.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VHKK@28216|Betaproteobacteria,1KK8A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Transporter	proP_2	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HFD2_k127_5532686_1	697282.Mettu_1728	3.221e-259	826.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1QF35@1224|Proteobacteria,1RXB1@1236|Gammaproteobacteria,1XGWF@135618|Methylococcales	135618|Methylococcales	P	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_5532686_5	338969.Rfer_3395	2.111e-102	376.0	COG0457@1|root,COG2202@1|root,COG5001@1|root,COG0457@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
HFD2_k127_5532686_3	565045.NOR51B_1736	5.329e-217	725.0	COG0642@1|root,COG0834@1|root,COG4251@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC2G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Hpt domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
HFD2_k127_5532686_4	1411685.U062_00014	4.316e-147	477.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1J54J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid desaturase	alkB1	GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
HFD2_k127_5532686_8	864051.BurJ1DRAFT_4848	4.278e-12	76.0	2CM4S@1|root,2ZQGG@2|Bacteria,1PAK6@1224|Proteobacteria,2W5A3@28216|Betaproteobacteria,1KP6X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cysteine-rich CWC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CWC
HFD2_k127_5532686_6	365046.Rta_16200	9.554e-91	301.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,4AA7T@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_5535115_7	1458357.BG58_35205	0.0003543	54.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,2VH67@28216|Betaproteobacteria,1JZQE@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM TatD-related deoxyribonuclease	yjjV	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD2_k127_5535115_5	983917.RGE_21640	6.47e-103	346.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,1KKMS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HFD2_k127_5535115_2	296591.Bpro_3891	9.954e-164	521.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,4AD31@80864|Comamonadaceae	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_5535115_4	296591.Bpro_3892	4.693e-134	435.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_5535115_3	864051.BurJ1DRAFT_3538	1.146e-152	493.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,1KKCR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HFD2_k127_5535115_1	1198452.Jab_1c25590	3.703e-203	645.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2VITU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tat pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD2_k127_5535115_0	1198452.Jab_1c25600	7.737e-207	657.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJD4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD2_k127_5535115_6	864051.BurJ1DRAFT_1761	2.705e-89	297.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,1KJN6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HFD2_k127_5553052_2	395495.Lcho_3608	3.321e-154	497.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,1KIUN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_5553052_5	543728.Vapar_4020	4.111e-108	360.0	COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,2VH2A@28216|Betaproteobacteria,4AAP8@80864|Comamonadaceae	28216|Betaproteobacteria	P	Mg2 transporter protein cora family protein	-	-	-	ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.4	-	-	CorA
HFD2_k127_5553052_3	1538295.JY96_05610	6.447e-134	439.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KMMR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HFD2_k127_5553052_4	983917.RGE_22520	9.397e-109	360.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria,1KN0X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
HFD2_k127_5553052_0	983917.RGE_22530	0.0	1099.0	COG1387@1|root,COG1387@2|Bacteria,1R4SE@1224|Proteobacteria,2WI8C@28216|Betaproteobacteria,1KN4S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5553052_1	1538295.JY96_05600	5.178e-302	950.0	COG0421@1|root,COG0421@2|Bacteria,1QY0T@1224|Proteobacteria,2WH8S@28216|Betaproteobacteria,1KMY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HFD2_k127_556568_2	864051.BurJ1DRAFT_4516	1.319e-168	539.0	COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,1KJWG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_CoxE
HFD2_k127_556568_4	748247.AZKH_p0464	8.816e-75	277.0	COG2014@1|root,COG2014@2|Bacteria,1MV5Z@1224|Proteobacteria,2VPCD@28216|Betaproteobacteria,2KUXD@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative heavy-metal chelation	-	-	-	-	-	-	-	-	-	-	-	-	DUF364,DUF4213
HFD2_k127_556568_5	1157708.KB907457_gene2595	4.501e-55	207.0	COG4321@1|root,COG4321@2|Bacteria,1MZP2@1224|Proteobacteria,2VU7X@28216|Betaproteobacteria,4AF4X@80864|Comamonadaceae	28216|Betaproteobacteria	S	Ribbon-helix-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
HFD2_k127_556568_3	1157708.KB907457_gene2594	5.213e-110	362.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2VM0T@28216|Betaproteobacteria,4ABFI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD2_k127_556568_8	1286631.X805_12230	4.371e-24	109.0	2EBXW@1|root,335X8@2|Bacteria,1NBMB@1224|Proteobacteria,2VWB7@28216|Betaproteobacteria,1KMJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_556568_7	864051.BurJ1DRAFT_0148	4.721e-26	124.0	COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria,2VVYE@28216|Betaproteobacteria,1KMP9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
HFD2_k127_556568_1	395495.Lcho_1818	1.248e-214	674.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WH5F@28216|Betaproteobacteria,1KPCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HFD2_k127_556568_0	1286631.X805_12200	0.0	1123.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,1KJ1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HFD2_k127_556568_6	1286631.X805_12190	1.657e-35	134.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria,1KKF6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K05796	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9
HFD2_k127_557860_7	358220.C380_04205	1.258e-96	317.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,4A9S3@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_557860_4	1265502.KB905932_gene1946	4.498e-116	381.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,4ABP2@80864|Comamonadaceae	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB_2	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD2_k127_557860_2	987059.RBXJA2T_17756	2.868e-136	448.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,1KIUQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD2_k127_557860_5	1265502.KB905932_gene1944	1.262e-115	394.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,4A9QE@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD2_k127_557860_13	637905.SVI_3836	6.061e-05	55.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,2QA09@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function, DUF484	yigA	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HFD2_k127_557860_3	420662.Mpe_A3243	2.082e-134	446.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2VJ5V@28216|Betaproteobacteria,1KJG0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_557860_6	1123392.AQWL01000001_gene1497	5.15e-110	361.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria	1224|Proteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_557860_9	290397.Adeh_2888	2.134e-35	142.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_557860_1	1265502.KB905932_gene1941	1.162e-206	647.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,4AADM@80864|Comamonadaceae	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HFD2_k127_557860_8	983917.RGE_05170	5.02e-72	248.0	COG1522@1|root,COG1522@2|Bacteria,1RD38@1224|Proteobacteria,2VRBA@28216|Betaproteobacteria,1KM51@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_557860_0	420662.Mpe_A0560	0.0	1060.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1KJ3T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HFD2_k127_557860_11	1121396.KB892935_gene3837	1.039e-19	102.0	COG0823@1|root,COG1409@1|root,COG0823@2|Bacteria,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	4.2.2.1	ko:K01727	-	-	-	-	ko00000,ko01000	-	PL8	-	F5_F8_type_C,Metallophos,PA14,SASA
HFD2_k127_5582271_6	543728.Vapar_1235	2.06e-37	144.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2VHQZ@28216|Betaproteobacteria,4A9YX@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM phenylacetic acid catabolic family protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD2_k127_5582271_3	543728.Vapar_1237	1.996e-67	233.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2VRC2@28216|Betaproteobacteria,4AEJU@80864|Comamonadaceae	28216|Betaproteobacteria	Q	phenylacetic acid degradation protein PaaD	paaI	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HFD2_k127_5582271_0	1265502.KB905938_gene2471	4.104e-103	348.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,4AA9M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the BI1 family	yccA	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HFD2_k127_5582271_1	114615.BRADO6189	8.07e-85	295.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VEZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5582271_5	272568.GDI2779	4.271e-48	181.0	COG2128@1|root,COG2128@2|Bacteria,1RBG0@1224|Proteobacteria,2U4DJ@28211|Alphaproteobacteria,2JTG8@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD2_k127_5582271_4	1244869.H261_11354	2.96e-55	213.0	COG0697@1|root,COG0697@2|Bacteria,1P38S@1224|Proteobacteria,2U1BY@28211|Alphaproteobacteria,2JQWZ@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_5582271_2	1144319.PMI16_04252	3.116e-71	241.0	COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria,2VP5W@28216|Betaproteobacteria,476YX@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_5596468_1	296591.Bpro_0021	2.546e-135	440.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,4AA4X@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HFD2_k127_5596468_0	365044.Pnap_1082	9.414e-227	704.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,4AA0K@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 2 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD2_k127_560982_4	983917.RGE_13910	1.795e-37	146.0	COG3184@1|root,COG3184@2|Bacteria,1RM4N@1224|Proteobacteria,2VT19@28216|Betaproteobacteria,1KM59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09924	-	-	-	-	ko00000	-	-	-	DUF2059
HFD2_k127_560982_1	395495.Lcho_0961	2.881e-203	636.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,1KJ05@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HFD2_k127_560982_2	1265502.KB905934_gene3183	3.32e-158	502.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,4AAQ0@80864|Comamonadaceae	28216|Betaproteobacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HFD2_k127_560982_0	987059.RBXJA2T_16507	2.381e-304	946.0	COG0128@1|root,COG0283@1|root,COG0128@2|Bacteria,COG0283@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,1KK6W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
HFD2_k127_560982_3	1265502.KB905934_gene3185	6.274e-141	452.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,4AC0A@80864|Comamonadaceae	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD2_k127_5642803_5	420662.Mpe_A1306	3.697e-12	68.0	2EPDE@1|root,33H00@2|Bacteria,1NIA5@1224|Proteobacteria,2VY7F@28216|Betaproteobacteria,1KMVS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5642803_1	864051.BurJ1DRAFT_2032	1.541e-134	437.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VMBM@28216|Betaproteobacteria,1KPHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953,ko:K18382	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703	RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_5642803_3	1265502.KB905934_gene3247	2.176e-75	273.0	COG0599@1|root,COG2267@1|root,COG0599@2|Bacteria,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2VJEH@28216|Betaproteobacteria,4ADNZ@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM alpha beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_5642803_4	987059.RBXJA2T_13824	1.005e-48	187.0	COG1262@1|root,COG1262@2|Bacteria,1Q227@1224|Proteobacteria,2VSH1@28216|Betaproteobacteria,1KM5M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SapC	-	-	-	-	-	-	-	-	-	-	-	-	SapC
HFD2_k127_5642803_0	864051.BurJ1DRAFT_4479	3.157e-208	655.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,1KJJI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HFD2_k127_5642803_2	864051.BurJ1DRAFT_4478	1.214e-127	412.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,1KJHU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
HFD2_k127_5642803_6	1453503.AU05_11570	7.76e-06	55.0	COG3832@1|root,COG3832@2|Bacteria,1QXZJ@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_5647694_9	338969.Rfer_0795	4.982e-20	93.0	COG4961@1|root,COG4961@2|Bacteria,1R58C@1224|Proteobacteria,2VJAX@28216|Betaproteobacteria,4AJWH@80864|Comamonadaceae	28216|Betaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD2_k127_5647694_11	76114.ebA3712	9.533e-10	63.0	2EFZ7@1|root,339RD@2|Bacteria,1NHET@1224|Proteobacteria,2VXR3@28216|Betaproteobacteria,2KXM7@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5647694_0	76114.ebA3713	3.356e-203	664.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VIVD@28216|Betaproteobacteria,2KV9T@206389|Rhodocyclales	206389|Rhodocyclales	U	Pilus formation protein N terminal region	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Secretin,T2SS-T3SS_pil_N
HFD2_k127_5647694_3	338969.Rfer_0792	5.737e-101	336.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2VMT6@28216|Betaproteobacteria,4ADPX@80864|Comamonadaceae	28216|Betaproteobacteria	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD2_k127_5647694_2	76114.ebA3716	4.002e-147	483.0	COG1239@1|root,COG1239@2|Bacteria,1QTYU@1224|Proteobacteria,2VJ0P@28216|Betaproteobacteria	28216|Betaproteobacteria	H	AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Mg_chelatase
HFD2_k127_5647694_7	29581.BW37_01865	2.403e-29	128.0	COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,2WIFE@28216|Betaproteobacteria,477P5@75682|Oxalobacteraceae	28216|Betaproteobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HFD2_k127_5647694_10	266264.Rmet_0653	1.494e-14	75.0	COG3847@1|root,COG3847@2|Bacteria,1PUR7@1224|Proteobacteria,2VXM6@28216|Betaproteobacteria,1KAXN@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HFD2_k127_5647694_12	338969.Rfer_0788	1.873e-08	62.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HFD2_k127_5647694_8	338969.Rfer_0787	3.803e-20	99.0	COG2197@1|root,COG2197@2|Bacteria,1PAZP@1224|Proteobacteria,2W5YC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_5647694_5	338969.Rfer_0786	6.792e-53	207.0	COG2020@1|root,COG2020@2|Bacteria,1N4VF@1224|Proteobacteria,2WFGX@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD2_k127_5647694_4	748247.AZKH_4120	8.314e-60	217.0	COG2197@1|root,COG2197@2|Bacteria,1RGN8@1224|Proteobacteria,2VRZK@28216|Betaproteobacteria,2KXUZ@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_5647694_6	338969.Rfer_0781	1.873e-50	200.0	COG4585@1|root,COG4585@2|Bacteria,1RBN9@1224|Proteobacteria,2VQ8I@28216|Betaproteobacteria,4AIBI@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD2_k127_5647694_1	266264.Rmet_5795	1.357e-173	557.0	COG1297@1|root,COG1297@2|Bacteria,1NQQP@1224|Proteobacteria	1224|Proteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD2_k127_5661267_7	314230.DSM3645_28082	1.256e-73	254.0	COG2253@1|root,COG2253@2|Bacteria,2J2AA@203682|Planctomycetes	203682|Planctomycetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HFD2_k127_5661267_0	420662.Mpe_A3332	1.583e-239	747.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,1KPM8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD2_k127_5661267_2	1265502.KB905932_gene1899	5.988e-163	558.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,4A9VQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HFD2_k127_5661267_3	1265502.KB905932_gene1898	6.362e-128	434.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,4A9N3@80864|Comamonadaceae	28216|Betaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD2_k127_5661267_1	1265502.KB905932_gene1897	4.458e-230	724.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,4AA94@80864|Comamonadaceae	28216|Betaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HFD2_k127_5661267_4	864051.BurJ1DRAFT_4442	6.241e-127	424.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,1KIT5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Displays ATPase and GTPase activities	yhbJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD2_k127_5661267_6	420662.Mpe_A3337	6.602e-82	280.0	COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,1KKT9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HFD2_k127_5661267_5	614083.AWQR01000015_gene2499	4.461e-85	299.0	COG0494@1|root,COG0494@2|Bacteria,1MWBQ@1224|Proteobacteria,2VQKK@28216|Betaproteobacteria,4AG8B@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_5661267_8	292.DM42_897	2.057e-38	147.0	COG0494@1|root,COG0494@2|Bacteria,1N317@1224|Proteobacteria,2WGF0@28216|Betaproteobacteria,1KDCF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4406
HFD2_k127_5661267_9	614083.AWQR01000015_gene2500	5.319e-36	140.0	COG1349@1|root,COG1349@2|Bacteria,1MXW2@1224|Proteobacteria,2VJT9@28216|Betaproteobacteria,4AGQ8@80864|Comamonadaceae	28216|Betaproteobacteria	K	DeoR C terminal sensor domain	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
HFD2_k127_5669998_4	987059.RBXJA2T_12307	5.679e-93	322.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2VIM5@28216|Betaproteobacteria,1KJWJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HFD2_k127_5669998_6	864051.BurJ1DRAFT_4522	1.89e-45	181.0	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,1KNN8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HFD2_k127_5669998_1	358220.C380_07875	6.32e-155	505.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,4AAKR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_5669998_7	864051.BurJ1DRAFT_1728	1.248e-05	50.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VHXA@28216|Betaproteobacteria,1KJKN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_5669998_2	420662.Mpe_A2022	9.9e-149	477.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,1KK8I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD2_k127_5669998_0	420662.Mpe_A1382	8.245e-310	952.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1KIZQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HFD2_k127_5669998_5	365046.Rta_15930	2.844e-76	263.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,4A9XY@80864|Comamonadaceae	28216|Betaproteobacteria	S	UPF0114 protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
HFD2_k127_5669998_3	1265502.KB905936_gene2683	7.189e-119	385.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,4AARI@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_5682660_1	522306.CAP2UW1_2627	4.117e-173	552.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VINV@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Radical SAM	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD2_k127_5682660_3	292415.Tbd_1586	3.122e-135	445.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,1KS3P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HFD2_k127_5682660_4	296591.Bpro_0929	1.175e-71	247.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD2_k127_5682660_2	296591.Bpro_1403	2.389e-153	494.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2VNMY@28216|Betaproteobacteria,4AGEE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HFD2_k127_5682660_0	338969.Rfer_4054	1.721e-186	590.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,4ACCT@80864|Comamonadaceae	28216|Betaproteobacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD2_k127_5682660_5	864051.BurJ1DRAFT_2912	9.577e-60	212.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2VIYE@28216|Betaproteobacteria,1KJAR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	splB	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD2_k127_5709972_2	1123504.JQKD01000007_gene3362	3.464e-106	350.0	COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,2VHIE@28216|Betaproteobacteria,4AB2F@80864|Comamonadaceae	28216|Betaproteobacteria	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HFD2_k127_5709972_0	614083.AWQR01000030_gene2824	0.0	1026.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_5709972_1	864051.BurJ1DRAFT_0138	2.172e-117	384.0	COG3687@1|root,COG3687@2|Bacteria,1R6G1@1224|Proteobacteria,2WFRN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
HFD2_k127_5709972_4	62928.azo3628	4.431e-20	94.0	2EIXZ@1|root,33CP5@2|Bacteria,1NIK8@1224|Proteobacteria,2VXRQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5709972_5	1265502.KB905930_gene1540	2.976e-19	94.0	2EPRG@1|root,33HBY@2|Bacteria,1NQE6@1224|Proteobacteria,2VXYF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5709972_3	1265502.KB905940_gene3012	3.695e-54	190.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,4AARH@80864|Comamonadaceae	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HFD2_k127_5716305_0	987059.RBXJA2T_07528	5e-324	1009.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1KJA0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HFD2_k127_5716305_2	987059.RBXJA2T_07533	1.307e-158	505.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,1KJ44@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HFD2_k127_5716305_9	420662.Mpe_A3808	3.865e-76	276.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,1KKN6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HFD2_k127_5716305_11	1223521.BBJX01000002_gene2846	1.872e-61	220.0	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,4ADJ4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HFD2_k127_5716305_5	365046.Rta_38130	7.459e-115	387.0	COG4221@1|root,COG4221@2|Bacteria,1QTVZ@1224|Proteobacteria,2WGPF@28216|Betaproteobacteria,4AJYI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_5716305_12	420662.Mpe_A3805	1.403e-48	182.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VRC4@28216|Betaproteobacteria,1KKP8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD2_k127_5716305_7	1265502.KB905951_gene845	3.139e-99	329.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria,4AA09@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM Multiple antibiotic resistance (MarC)-related	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HFD2_k127_5716305_6	1297863.APJF01000029_gene1398	1.409e-111	370.0	COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,2TV4S@28211|Alphaproteobacteria,3JRRM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	MA20_36470	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_5716305_8	709797.CSIRO_3341	3.775e-95	327.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2U1KC@28211|Alphaproteobacteria,3JU5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	yjiJ	-	-	-	-	-	-	-	-	-	-	-	MFS_4
HFD2_k127_5716305_10	883078.HMPREF9695_02185	9.422e-67	249.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2TQSD@28211|Alphaproteobacteria,3JUX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD2_k127_5716305_1	864051.BurJ1DRAFT_5007	5.728e-264	834.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1KJR1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the GMC oxidoreductase family	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD2_k127_5716305_3	1157708.KB907456_gene2260	3.042e-135	436.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,4AB5Q@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD2_k127_5716305_13	420662.Mpe_A2148	6.585e-48	183.0	COG0431@1|root,COG0431@2|Bacteria,1MX40@1224|Proteobacteria,2VQFT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	fmn reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
HFD2_k127_5716305_4	266264.Rmet_1370	2.603e-131	428.0	COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2VH5V@28216|Betaproteobacteria,1K1IU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein	ssuA1	-	-	ko:K15553	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.2	-	-	NMT1,NMT1_2
HFD2_k127_5727656_3	987059.RBXJA2T_19561	5.338e-154	512.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,1KJ3I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_5727656_1	1265502.KB905930_gene1563	2.318e-242	753.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,4A9MU@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM aminotransferase, class I and II	alaA	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_5727656_6	983917.RGE_32610	6.704e-40	151.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,1KM8T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HFD2_k127_5727656_5	395495.Lcho_2028	6.137e-89	295.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,1KK9V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD2_k127_5727656_0	983917.RGE_32630	2.201e-287	889.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,1KJEJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HFD2_k127_5727656_4	420662.Mpe_A1359	8.365e-95	320.0	COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,1KKDG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA ligase	dnaL	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_M,DNA_ligase_OB_2
HFD2_k127_5727656_2	614083.AWQR01000011_gene2319	4.875e-156	495.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,4A9US@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_5729387_2	864051.BurJ1DRAFT_1381	2.461e-89	295.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,1KJ4A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	urea ABC transporter, ATP-binding protein	urtE	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
HFD2_k127_5729387_4	420662.Mpe_A2179	1.084e-76	271.0	COG1653@1|root,COG1653@2|Bacteria,1R5TB@1224|Proteobacteria,2VUUT@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HFD2_k127_5729387_6	118173.KB235914_gene1097	5.003e-46	182.0	COG0683@1|root,COG0683@2|Bacteria,1G4Y1@1117|Cyanobacteria	1117|Cyanobacteria	E	leucine binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5729387_1	1538295.JY96_02765	1.331e-112	386.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,2VHXH@28216|Betaproteobacteria,1KJDP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
HFD2_k127_5729387_5	358220.C380_00200	4.175e-72	257.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2VQN8@28216|Betaproteobacteria,4AE1T@80864|Comamonadaceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD2_k127_5729387_3	378806.STAUR_7858	1.756e-84	284.0	COG1896@1|root,COG1896@2|Bacteria,1MXEZ@1224|Proteobacteria,42SK8@68525|delta/epsilon subdivisions,2WPU3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
HFD2_k127_5729387_0	243365.CV_1441	2.779e-152	485.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,2KQSB@206351|Neisseriales	206351|Neisseriales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD2_k127_5753076_2	1265502.KB905933_gene1984	1.04e-98	334.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,4ACV5@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HFD2_k127_5753076_7	1123256.KB907925_gene1293	1.033e-42	158.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,1T07B@1236|Gammaproteobacteria,1X8T2@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1255
HFD2_k127_5753076_6	987059.RBXJA2T_16742	1.974e-45	171.0	COG3915@1|root,COG3915@2|Bacteria,1RHJS@1224|Proteobacteria,2VRRX@28216|Betaproteobacteria,1KKU8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD2_k127_5753076_1	864051.BurJ1DRAFT_3850	1.801e-172	574.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJDC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,Response_reg
HFD2_k127_5753076_0	1265502.KB905964_gene1385	2.11e-187	591.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,4AA6J@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD2_k127_5753076_3	420662.Mpe_A3039	1.247e-75	256.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,1KKT8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0234 family	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HFD2_k127_5753076_5	420662.Mpe_A3040	4.984e-60	214.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,1KM5G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HFD2_k127_5753076_4	1195246.AGRI_10071	1e-68	248.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RQHM@1236|Gammaproteobacteria,467Q9@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Alpha amylase, catalytic domain	-	-	3.2.1.133,3.2.1.135,3.2.1.20,3.2.1.54	ko:K01187,ko:K01208,ko:K21575	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R02112,R03122,R06087,R06088,R11262	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Alpha-amylase_N,Cyc-maltodext_C,Cyc-maltodext_N,Malt_amylase_C
HFD2_k127_5806508_6	987059.RBXJA2T_10434	6.455e-14	73.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,1KK7T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_5806508_3	864051.BurJ1DRAFT_3460	4.706e-51	192.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,1KM4H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD2_k127_5806508_5	983917.RGE_31720	4.37e-31	127.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1KMN9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	'Cold-shock' DNA-binding domain	cspD	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_5806508_0	365046.Rta_21850	1.425e-255	790.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,4ABW5@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	icd	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_5806508_4	983917.RGE_31840	7.718e-48	195.0	COG2836@1|root,COG2836@2|Bacteria,1PN2Q@1224|Proteobacteria,2VNU4@28216|Betaproteobacteria,1KM8Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HFD2_k127_5806508_1	1265502.KB905930_gene1475	6.519e-215	676.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,4ABSD@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD2_k127_5806508_2	864051.BurJ1DRAFT_3496	6.387e-82	276.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,1KJZH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_5829950_4	365046.Rta_16450	5.337e-166	543.0	COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,4AC9X@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HFD2_k127_5829950_13	395495.Lcho_2662	8.552e-77	281.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2VMI0@28216|Betaproteobacteria,1KJJN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD2_k127_5829950_11	395495.Lcho_2663	6.896e-101	352.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,1KIZD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HFD2_k127_5829950_12	420662.Mpe_A2307	6.442e-89	329.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1KK88@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
HFD2_k127_5829950_3	1286631.X805_28590	3.204e-200	640.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,1KJFR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	outer membrane cobalamin receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HFD2_k127_5829950_2	269482.Bcep1808_2978	2.29e-228	741.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,1K25C@119060|Burkholderiaceae	28216|Betaproteobacteria	M	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_5829950_7	987059.RBXJA2T_14926	6.393e-156	503.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,1KJQ7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	mechanosensitive ion channel	aefA	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD2_k127_5829950_8	864051.BurJ1DRAFT_1020	1.366e-145	469.0	COG3181@1|root,COG3181@2|Bacteria,1N00G@1224|Proteobacteria,2VN46@28216|Betaproteobacteria,1KJ3Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_5829950_5	864051.BurJ1DRAFT_2797	3.128e-160	510.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,1KJ7N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	BQ	histone deacetylase	hdaH	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_5829950_6	420662.Mpe_A1245	1.567e-159	506.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,1KJ4M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD2_k127_5829950_10	420662.Mpe_A1244	8.921e-114	378.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,1KKHQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD2_k127_5829950_0	864051.BurJ1DRAFT_2800	7.171e-268	845.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,1KJX0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HFD2_k127_5829950_9	420662.Mpe_A1242	6.603e-140	453.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,1KK54@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
HFD2_k127_5829950_1	296591.Bpro_2149	9.416e-231	727.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,4ACBD@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	rosB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HFD2_k127_5839832_2	864051.BurJ1DRAFT_4536	4.552e-234	762.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KNF8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
HFD2_k127_5839832_1	864051.BurJ1DRAFT_4536	2.013e-237	766.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KNF8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg
HFD2_k127_5839832_7	420662.Mpe_A3625	1.569e-123	424.0	COG0284@1|root,COG0284@2|Bacteria,1MWH5@1224|Proteobacteria,2VHAB@28216|Betaproteobacteria,1KKBC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HFD2_k127_5839832_0	420662.Mpe_A3624	7.195e-242	753.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1KJIE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
HFD2_k127_5839832_4	987059.RBXJA2T_04633	3.923e-171	543.0	COG1744@1|root,COG1744@2|Bacteria,1MVU5@1224|Proteobacteria,2VKZI@28216|Betaproteobacteria,1KKIH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	basic membrane	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
HFD2_k127_5839832_3	864051.BurJ1DRAFT_1729	7.328e-217	688.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,1KIYS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_5839832_5	987059.RBXJA2T_04653	1.007e-157	505.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VHXA@28216|Betaproteobacteria,1KJKN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_5839832_6	983917.RGE_45780	1.154e-151	501.0	COG1079@1|root,COG1079@2|Bacteria,1NAYV@1224|Proteobacteria,2VJ78@28216|Betaproteobacteria,1KKEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HFD2_k127_5839832_8	1538295.JY96_15350	6.376e-33	130.0	2DPTK@1|root,333BS@2|Bacteria,1QVH8@1224|Proteobacteria,2VWD4@28216|Betaproteobacteria,1KP2T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HFD2_k127_5839832_9	1121028.ARQE01000003_gene778	6.474e-20	93.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,2PKF0@255475|Aurantimonadaceae	28211|Alphaproteobacteria	F	Pyrimidine nucleoside phosphorylase C-terminal domain	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD2_k127_5846140_1	420662.Mpe_A3516	6.232e-168	537.0	COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2VKX4@28216|Betaproteobacteria,1KJ03@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	PhoD-like phosphatase, N-terminal domain	phoD2	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
HFD2_k127_5846140_4	522306.CAP2UW1_1845	1.926e-23	100.0	COG5010@1|root,COG5010@2|Bacteria,1R0QI@1224|Proteobacteria,2VX62@28216|Betaproteobacteria,1KR08@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5846140_6	522306.CAP2UW1_1845	5.243e-12	72.0	COG5010@1|root,COG5010@2|Bacteria,1R0QI@1224|Proteobacteria,2VX62@28216|Betaproteobacteria,1KR08@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5846140_2	1000565.METUNv1_03385	3.093e-54	202.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2VJ7E@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_5846140_3	1349767.GJA_5388	5.532e-41	169.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_5846140_0	420662.Mpe_A2203	1.121e-185	593.0	COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2VHDP@28216|Betaproteobacteria,1KJ55@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	MreB/Mbl protein	yegD	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
HFD2_k127_5846140_5	365044.Pnap_1536	3.002e-23	100.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,4A9VC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_5874793_8	1265502.KB905932_gene1928	2.068e-58	205.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2VSPA@28216|Betaproteobacteria,4ADZT@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcription regulator MerR DNA binding	zntR	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
HFD2_k127_5874793_1	395495.Lcho_4200	5.102e-175	554.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,1KJ2U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5874793_5	420662.Mpe_A3371	4.053e-95	318.0	COG1802@1|root,COG1802@2|Bacteria,1R96W@1224|Proteobacteria,2VQJC@28216|Betaproteobacteria,1KKQU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_5874793_4	420662.Mpe_A3372	8.302e-148	489.0	COG1177@1|root,COG1177@2|Bacteria,1MV84@1224|Proteobacteria,2VJIR@28216|Betaproteobacteria,1KK6X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_5874793_3	420662.Mpe_A3373	2.78e-158	502.0	COG1176@1|root,COG1176@2|Bacteria,1MW13@1224|Proteobacteria,2VKAG@28216|Betaproteobacteria,1KJJ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HFD2_k127_5874793_0	420662.Mpe_A3374	5.317e-250	795.0	COG0687@1|root,COG0687@2|Bacteria,1MW93@1224|Proteobacteria,2VID1@28216|Betaproteobacteria,1KJB0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HFD2_k127_5874793_2	420662.Mpe_A3375	3.34e-173	549.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VMG0@28216|Betaproteobacteria,1KJJB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TOBE domain	-	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
HFD2_k127_5874793_7	395495.Lcho_0210	4.131e-84	303.0	COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2VIW8@28216|Betaproteobacteria,1KKFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Asp/Glu/Hydantoin racemase	hyuE	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HFD2_k127_5874793_6	1265502.KB905934_gene3278	4.476e-89	295.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2VNC5@28216|Betaproteobacteria,4A9K3@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HFD2_k127_5882705_3	1286631.X805_28180	4.449e-10	60.0	COG3021@1|root,COG3021@2|Bacteria,1NJVF@1224|Proteobacteria,2W177@28216|Betaproteobacteria,1KN3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_5882705_0	420662.Mpe_A1360	2.367e-230	721.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,2VINN@28216|Betaproteobacteria,1KJ9N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Exonuclease C-terminal	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
HFD2_k127_5882705_2	107636.JQNK01000002_gene173	1.283e-11	68.0	COG0491@1|root,COG0491@2|Bacteria,1R6GR@1224|Proteobacteria,2U3IN@28211|Alphaproteobacteria,36ZA7@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_5882705_1	987059.RBXJA2T_09959	1.212e-24	106.0	2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,2VRRJ@28216|Betaproteobacteria,1KKVZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5908085_8	864051.BurJ1DRAFT_2606	4.794e-12	68.0	COG3913@1|root,COG3913@2|Bacteria	2|Bacteria	T	Uncharacterized protein conserved in bacteria (DUF2094)	-	-	-	ko:K11890	ko02025,map02025	-	-	-	ko00000,ko00001,ko02044	-	-	-	DUF2094
HFD2_k127_5908085_0	864051.BurJ1DRAFT_2607	0.0	1240.0	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2VJ0M@28216|Betaproteobacteria,1KK2W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	type VI secretion protein	icmF	-	-	-	-	-	-	-	-	-	-	-	IcmF-related,IcmF_C,ImcF-related_N
HFD2_k127_5908085_3	864051.BurJ1DRAFT_2608	4.702e-113	376.0	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2VMB4@28216|Betaproteobacteria	28216|Betaproteobacteria	N	TIGRFAM type IV VI secretion system protein, DotU family	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
HFD2_k127_5908085_1	864051.BurJ1DRAFT_2609	1.372e-167	537.0	COG3521@1|root,COG4249@1|root,COG3521@2|Bacteria,COG4249@2|Bacteria,1PFRD@1224|Proteobacteria,2WANK@28216|Betaproteobacteria,1KMT8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113	-	-	-	ko:K11906	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS-SciN
HFD2_k127_5908085_2	864051.BurJ1DRAFT_2610	6.563e-120	395.0	COG4249@1|root,COG4249@2|Bacteria,1R3WZ@1224|Proteobacteria,2VSB5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD2_k127_5908085_5	864051.BurJ1DRAFT_2611	7.294e-75	256.0	2ES5B@1|root,33JQ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_5908085_4	864051.BurJ1DRAFT_2612	1.123e-92	308.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2VW3D@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_5908085_7	1123504.JQKD01000034_gene2746	9.908e-19	90.0	2E7T6@1|root,3328B@2|Bacteria,1N8UT@1224|Proteobacteria,2VVWC@28216|Betaproteobacteria,4AG0G@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5908085_6	62928.azo3774	1.069e-65	248.0	COG0515@1|root,COG0515@2|Bacteria,1P64D@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	pkn9	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_5908085_9	1472716.KBK24_0106805	8.687e-11	68.0	2AGQQ@1|root,316YG@2|Bacteria,1PY68@1224|Proteobacteria,2WDF9@28216|Betaproteobacteria,1KA72@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_590844_6	864051.BurJ1DRAFT_0416	8.358e-26	110.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,1KJHE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Has an organic peroxide-dependent peroxidase activity	katE	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel,DJ-1_PfpI
HFD2_k127_590844_4	864051.BurJ1DRAFT_3571	9.364e-72	257.0	COG2214@1|root,COG2214@2|Bacteria,1RDYT@1224|Proteobacteria,2VMYD@28216|Betaproteobacteria,1KMQ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_590844_0	1157708.KB907451_gene4539	1.028e-171	557.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,4AAIW@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD2_k127_590844_1	395495.Lcho_0175	3.467e-122	418.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KJNR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_590844_3	1232410.KI421424_gene1698	1.249e-95	335.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_590844_2	1232410.KI421424_gene1697	2.627e-110	369.0	COG1410@1|root,COG1410@2|Bacteria,1NSVT@1224|Proteobacteria	1224|Proteobacteria	E	Pterin binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_bind
HFD2_k127_590844_5	1232410.KI421424_gene1696	6.667e-31	124.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,43TR4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HFD2_k127_5963751_5	864051.BurJ1DRAFT_0757	8.13e-170	535.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1KKF2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	hpaE	-	1.2.1.32,1.2.1.60,1.2.1.85	ko:K00151,ko:K10217	ko00350,ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00350,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00533,M00569	R02762,R03889,R04418,R05353	RC00218,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_5963751_6	864051.BurJ1DRAFT_0758	5.919e-166	530.0	COG3384@1|root,COG3384@2|Bacteria,1MWNC@1224|Proteobacteria,2VK29@28216|Betaproteobacteria	28216|Betaproteobacteria	S	3,4-dihydroxyphenylacetate 2,3-dioxygenase	hpaD	-	1.13.11.15	ko:K00455	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R03303	RC00643	ko00000,ko00001,ko00002,ko01000	-	-	-	LigB
HFD2_k127_5963751_11	748247.AZKH_4047	6.296e-117	396.0	COG1108@1|root,COG1108@2|Bacteria,1PM37@1224|Proteobacteria,2VM6C@28216|Betaproteobacteria,2KY4A@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HFD2_k127_5963751_8	748247.AZKH_4048	9.753e-153	503.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,2VHKN@28216|Betaproteobacteria,2KVG9@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
HFD2_k127_5963751_4	748247.AZKH_4049	2.995e-203	645.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria,2KUH1@206389|Rhodocyclales	206389|Rhodocyclales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5963751_18	864051.BurJ1DRAFT_0037	4.214e-10	66.0	2EKHK@1|root,33E7J@2|Bacteria,1NK5D@1224|Proteobacteria,2VXVC@28216|Betaproteobacteria,1KMV6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5963751_13	864051.BurJ1DRAFT_0038	9.24e-81	276.0	COG2771@1|root,COG2771@2|Bacteria,1R05Y@1224|Proteobacteria,2WF1E@28216|Betaproteobacteria,1KKYH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Autoinducer binding domain	-	-	-	ko:K07782	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
HFD2_k127_5963751_7	1163617.SCD_n01992	1.708e-154	503.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_5963751_17	357808.RoseRS_4624	2.76e-32	133.0	COG1324@1|root,COG1324@2|Bacteria,2GAUD@200795|Chloroflexi,377VA@32061|Chloroflexia	32061|Chloroflexia	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD2_k127_5963751_15	596154.Alide2_2878	2.586e-38	153.0	2BJY7@1|root,32EAU@2|Bacteria,1RM1I@1224|Proteobacteria,2VTP4@28216|Betaproteobacteria,4AF7I@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_5963751_0	395495.Lcho_2036	0.0	1028.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KKDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD2_k127_5963751_10	338969.Rfer_2147	6.516e-149	481.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,4AAH8@80864|Comamonadaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_5963751_16	543913.D521_0624	7.941e-37	159.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_5963751_1	1123368.AUIS01000003_gene1787	8.83e-285	900.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NCC6@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD2_k127_5963751_14	395495.Lcho_2512	1.572e-77	266.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,2VQ4Q@28216|Betaproteobacteria,1KKNZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD2_k127_5963751_3	420662.Mpe_A2526	1.407e-223	709.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1KJAV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_5963751_12	215803.DB30_0841	2.367e-99	359.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HFD2_k127_5963751_9	864051.BurJ1DRAFT_4668	4.24e-150	506.0	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,2VPSC@28216|Betaproteobacteria,1KMH2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_5963751_2	85643.Tmz1t_2824	1.353e-259	837.0	COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,2VMYV@28216|Betaproteobacteria,2KYY0@206389|Rhodocyclales	206389|Rhodocyclales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HFD2_k127_596804_8	794903.OPIT5_02955	1.954e-32	141.0	COG0745@1|root,COG0745@2|Bacteria,46UGY@74201|Verrucomicrobia,3K7XC@414999|Opitutae	414999|Opitutae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07663	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_596804_3	420662.Mpe_A0450	5.079e-165	526.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1KJNM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_596804_2	420662.Mpe_A0134	2.218e-183	580.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,1KJ6M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD2_k127_596804_0	987059.RBXJA2T_16942	3.181e-295	920.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,1KJN8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD2_k127_596804_5	864051.BurJ1DRAFT_0554	1.477e-71	249.0	COG3318@1|root,COG3318@2|Bacteria,1QF7R@1224|Proteobacteria,2VP9G@28216|Betaproteobacteria,1KJUA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0149)	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HFD2_k127_596804_1	864051.BurJ1DRAFT_0555	1.022e-287	889.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,1KK5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA_2	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_596804_4	264730.PSPPH_2735	5.278e-102	347.0	2EZWV@1|root,33T15@2|Bacteria,1NQXM@1224|Proteobacteria,1SK4I@1236|Gammaproteobacteria,1Z8FC@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HFD2_k127_596804_6	264730.PSPPH_2734	5.427e-47	175.0	COG4731@1|root,COG4731@2|Bacteria,1N4UZ@1224|Proteobacteria,1T0W9@1236|Gammaproteobacteria,1Z8ST@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HFD2_k127_596804_7	1538295.JY96_11870	1.089e-33	132.0	COG3616@1|root,COG3616@2|Bacteria,1MXV3@1224|Proteobacteria,2VIPE@28216|Betaproteobacteria,1KN8H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HFD2_k127_5969638_3	234267.Acid_2430	2.182e-42	171.0	COG4941@1|root,COG4941@2|Bacteria,3Y42G@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
HFD2_k127_5969638_4	1144275.COCOR_00143	1.275e-26	116.0	COG3795@1|root,COG3795@2|Bacteria,1NJ4J@1224|Proteobacteria	1224|Proteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD2_k127_5969638_0	1123504.JQKD01000029_gene4191	1.476e-135	439.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VHV1@28216|Betaproteobacteria,4ABAB@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_5969638_5	987059.RBXJA2T_19391	8.388e-23	105.0	COG2823@1|root,COG2823@2|Bacteria,1NIM8@1224|Proteobacteria,2VX5E@28216|Betaproteobacteria,1KNVY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_5969638_2	1268622.AVS7_04552	1.35e-67	240.0	COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,2VKK9@28216|Betaproteobacteria,4AABS@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD2_k127_5969638_1	365044.Pnap_1790	1.087e-121	398.0	COG1463@1|root,COG1463@2|Bacteria,1R565@1224|Proteobacteria,2VK63@28216|Betaproteobacteria,4AA5X@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD2_k127_5969638_6	1198452.Jab_2c16890	1.311e-07	61.0	29DRS@1|root,300PM@2|Bacteria,1RF8B@1224|Proteobacteria,2VR3X@28216|Betaproteobacteria,475VG@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_602126_4	1266925.JHVX01000001_gene2742	6.198e-49	179.0	2BIJA@1|root,32CS2@2|Bacteria,1RHJT@1224|Proteobacteria,2VT9T@28216|Betaproteobacteria,373T5@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,VPEP
HFD2_k127_602126_6	1123504.JQKD01000023_gene208	4.465e-43	158.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,4ABUC@80864|Comamonadaceae	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HFD2_k127_602126_3	1265502.KB905938_gene2445	8.128e-91	307.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,4ABUC@80864|Comamonadaceae	28216|Betaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HFD2_k127_602126_1	1265502.KB905938_gene2444	7.193e-116	375.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,4AA2J@80864|Comamonadaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD2_k127_602126_2	864051.BurJ1DRAFT_4464	8.972e-105	362.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,1KJTJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HFD2_k127_602126_0	1286631.X805_28430	4.94e-176	562.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,1KK22@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_602126_5	1504672.669784117	5.913e-47	169.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,4ABD8@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HFD2_k127_6118680_5	420662.Mpe_A0780	3.612e-26	108.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,1KJ02@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD2_k127_6118680_4	420662.Mpe_A0779	4.982e-49	178.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,2VUG8@28216|Betaproteobacteria,1KMCQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
HFD2_k127_6118680_3	420662.Mpe_A0778	2.352e-93	315.0	COG1802@1|root,COG1802@2|Bacteria,1R96W@1224|Proteobacteria,2VIQU@28216|Betaproteobacteria,1KJ1M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_6118680_0	1120999.JONM01000021_gene118	1.877e-173	573.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2VJQR@28216|Betaproteobacteria,2KRPQ@206351|Neisseriales	206351|Neisseriales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD2_k127_6118680_2	296591.Bpro_0157	1.201e-149	480.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VNHK@28216|Betaproteobacteria,4AGFZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_6118680_1	365044.Pnap_0354	1.216e-166	533.0	COG0624@1|root,COG3195@1|root,COG0624@2|Bacteria,COG3195@2|Bacteria,1MVUX@1224|Proteobacteria,2VIGB@28216|Betaproteobacteria,4AB68@80864|Comamonadaceae	28216|Betaproteobacteria	E	Amidase, hydantoinase carbamoylase family	uraD	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,OHCU_decarbox,Peptidase_M20,Peptidase_M28
HFD2_k127_6149433_0	1288494.EBAPG3_13360	1.589e-285	893.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,372U6@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01583	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HFD2_k127_6149433_7	983917.RGE_14930	2.394e-105	347.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2VIX0@28216|Betaproteobacteria,1KK4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
HFD2_k127_6149433_1	987059.RBXJA2T_12357	2.884e-175	562.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,1KN3N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HFD2_k127_6149433_3	420662.Mpe_A0131	1.394e-131	432.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,2VJ9K@28216|Betaproteobacteria,1KK0H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	ET	Ligated ion channel L-glutamate- and glycine-binding site	-	-	-	ko:K02030,ko:K10036	ko02010,map02010	M00227,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.2	-	-	SBP_bac_3
HFD2_k127_6149433_4	983917.RGE_14900	3.376e-121	395.0	COG0765@1|root,COG0765@2|Bacteria,1P3W6@1224|Proteobacteria,2VKIE@28216|Betaproteobacteria,1KJTD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD2_k127_6149433_5	1265502.KB905931_gene1656	4.498e-117	385.0	COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VMU4@28216|Betaproteobacteria,4ACEH@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM porin Gram-negative type	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_6149433_8	1265502.KB905931_gene1657	7.661e-83	280.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,2VMIW@28216|Betaproteobacteria,4ABCK@80864|Comamonadaceae	28216|Betaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HFD2_k127_6149433_2	983917.RGE_34540	3.554e-175	582.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KMS8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
HFD2_k127_6149433_10	1538295.JY96_09290	6.3e-08	60.0	COG0662@1|root,COG0662@2|Bacteria,1N40H@1224|Proteobacteria,2VWGU@28216|Betaproteobacteria,1KP6U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Auxin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Auxin_BP,Cupin_2
HFD2_k127_6149433_11	75379.Tint_0709	2.989e-05	55.0	28ME7@1|root,2ZARX@2|Bacteria,1R90X@1224|Proteobacteria,2VNB6@28216|Betaproteobacteria,1KM2D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_6149433_9	358220.C380_02835	1.526e-59	225.0	28ME7@1|root,2ZARX@2|Bacteria,1R90X@1224|Proteobacteria,2VNB6@28216|Betaproteobacteria,4AA7V@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_6149433_6	365044.Pnap_3156	1.191e-108	363.0	COG2010@1|root,COG2010@2|Bacteria,1NEUK@1224|Proteobacteria,2W1CP@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_615351_2	987059.RBXJA2T_19561	2.937e-156	495.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,1KJ3I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HFD2_k127_615351_0	420662.Mpe_A1542	3.915e-243	765.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,1KK4V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HFD2_k127_615351_1	266264.Rmet_1964	4.169e-162	542.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,1JZXP@119060|Burkholderiaceae	28216|Betaproteobacteria	H	MoeA domain protein domain I and II	moeA1	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD2_k127_615351_3	395495.Lcho_2021	2.77e-26	115.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,1KMNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD2_k127_6158870_5	1157708.KB907450_gene6176	1.586e-47	187.0	COG1566@1|root,COG1566@2|Bacteria,1MXZV@1224|Proteobacteria,2VJEY@28216|Betaproteobacteria,4AG6X@80864|Comamonadaceae	28216|Betaproteobacteria	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_6158870_2	1157708.KB907450_gene6175	1.438e-130	432.0	COG1538@1|root,COG1538@2|Bacteria,1N23P@1224|Proteobacteria,2VK1N@28216|Betaproteobacteria,4AGH7@80864|Comamonadaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_6158870_3	395495.Lcho_3654	5.735e-130	419.0	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2VKPD@28216|Betaproteobacteria,1KK35@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_6158870_0	395495.Lcho_3655	4.18e-289	896.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,1KKG3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_6158870_4	388051.AUFE01000002_gene431	1.478e-78	266.0	COG1012@1|root,COG1012@2|Bacteria,1QYJ1@1224|Proteobacteria,2WHFK@28216|Betaproteobacteria,1KINX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Domain of unknown function (DUF4863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4863
HFD2_k127_6158870_1	426114.THI_0469	1.381e-143	460.0	COG0703@1|root,COG0703@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,1KIZ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK_2	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,SKI
HFD2_k127_6161964_4	864051.BurJ1DRAFT_4936	6.82e-13	68.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2VSPC@28216|Betaproteobacteria,1KMDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HFD2_k127_6161964_2	864051.BurJ1DRAFT_4933	3.033e-129	418.0	COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2VMAE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD2_k127_6161964_3	420662.Mpe_A0100	1.449e-85	291.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2VKX5@28216|Betaproteobacteria,1KN0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_6161964_1	983917.RGE_00320	3.385e-170	543.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KIYX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_8
HFD2_k127_6161964_0	864051.BurJ1DRAFT_4930	4.662e-216	674.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1KJMG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_6164612_0	760117.JN27_01800	3.458e-189	599.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2W0KT@28216|Betaproteobacteria,476SR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_6164612_3	477184.KYC_24592	1.021e-64	227.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2VSCM@28216|Betaproteobacteria,3T4M8@506|Alcaligenaceae	28216|Betaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_6164612_2	1123504.JQKD01000002_gene3754	4.389e-106	355.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_6164612_1	1123504.JQKD01000002_gene3753	1.558e-122	406.0	COG2770@1|root,COG2770@2|Bacteria,1QZYS@1224|Proteobacteria,2VJTC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
HFD2_k127_6164612_4	1123504.JQKD01000002_gene3752	1.964e-29	122.0	2BWWN@1|root,32XHS@2|Bacteria,1N289@1224|Proteobacteria,2VU35@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_6168603_1	395495.Lcho_1553	6.908e-146	470.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PD5J@1224|Proteobacteria,2W9PK@28216|Betaproteobacteria,1KMZ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
HFD2_k127_6168603_9	864051.BurJ1DRAFT_0330	1.964e-21	100.0	COG2916@1|root,COG2916@2|Bacteria,1NB7Y@1224|Proteobacteria,2VVZE@28216|Betaproteobacteria,1KMPR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	H-NS histone family	-	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
HFD2_k127_6168603_7	118166.JH976537_gene3495	1.178e-53	191.0	COG0346@1|root,COG0346@2|Bacteria,1G9WA@1117|Cyanobacteria,1HGM9@1150|Oscillatoriales	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_6168603_4	1041142.ATTP01000015_gene6864	7.418e-117	396.0	COG2931@1|root,COG2931@2|Bacteria,1QYJ2@1224|Proteobacteria,2TY04@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HFD2_k127_6168603_3	1095769.CAHF01000011_gene2062	1.681e-117	396.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VJGK@28216|Betaproteobacteria,473SZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
HFD2_k127_6168603_0	1458357.BG58_35310	1.371e-153	515.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WHDJ@28216|Betaproteobacteria,1KIMS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_4,PAS_8,PAS_9,Response_reg
HFD2_k127_6168603_2	748247.AZKH_4185	2.393e-141	458.0	COG2866@1|root,COG2866@2|Bacteria,1NW73@1224|Proteobacteria,2VJH0@28216|Betaproteobacteria,2KY5D@206389|Rhodocyclales	206389|Rhodocyclales	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_6168603_6	1123261.AXDW01000009_gene146	1.011e-67	252.0	COG2267@1|root,COG2267@2|Bacteria,1RBM5@1224|Proteobacteria,1S64F@1236|Gammaproteobacteria,1X78C@135614|Xanthomonadales	135614|Xanthomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_6168603_12	1240350.AMZE01000030_gene2018	0.0001146	49.0	COG3251@1|root,COG3251@2|Bacteria,1NH51@1224|Proteobacteria,1SZRC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antibiotic synthesis protein MbtH	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
HFD2_k127_6168603_5	886293.Sinac_1023	1.557e-92	343.0	COG2133@1|root,COG2133@2|Bacteria,2J14W@203682|Planctomycetes	203682|Planctomycetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	CBM60,Calx-beta,DUF4347,GSDH,Lectin_legB
HFD2_k127_6168603_10	1219076.N646_4225	1.852e-17	98.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1R3YZ@1224|Proteobacteria,1RY6I@1236|Gammaproteobacteria,1XTSH@135623|Vibrionales	135623|Vibrionales	G	protein contain chitin-binding domain type 3	-	-	3.2.1.14,3.2.1.202	ko:K01183,ko:K21606	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	CBM5,GH18	-	CBM_5_12_2,ChiC,Glyco_hydro_18
HFD2_k127_6168603_11	1121007.AUML01000014_gene2925	1.338e-11	79.0	COG3258@1|root,COG3979@1|root,COG5295@1|root,COG3258@2|Bacteria,COG3979@2|Bacteria,COG5295@2|Bacteria,4NM24@976|Bacteroidetes,1I2FB@117743|Flavobacteriia	976|Bacteroidetes	G	Chitinase class I	-	-	3.2.1.14	ko:K20547	ko00520,ko01100,ko04016,map00520,map01100,map04016	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	CBM18,GH19	-	Glyco_hydro_19
HFD2_k127_6168603_8	1123320.KB889698_gene9323	1.644e-27	132.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
HFD2_k127_6168652_5	204669.Acid345_2450	1.714e-08	68.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Collagen,fn3
HFD2_k127_6168652_1	886293.Sinac_1023	7.441e-99	347.0	COG2133@1|root,COG2133@2|Bacteria,2J14W@203682|Planctomycetes	203682|Planctomycetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	CBM60,Calx-beta,DUF4347,GSDH,Lectin_legB
HFD2_k127_6168652_0	420662.Mpe_A0127	7.318e-149	477.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,1KIZ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator	cbl	-	-	ko:K13634,ko:K13635	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6168652_4	1123073.KB899242_gene1161	2.42e-20	98.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,1S48U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_6168652_2	626418.bglu_2g15360	3.199e-72	256.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria,1K25X@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_6168652_3	269482.Bcep1808_5636	1.666e-50	199.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,2VHKW@28216|Betaproteobacteria,1JZRD@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_6169187_12	296591.Bpro_3380	6.191e-77	261.0	COG0410@1|root,COG0410@2|Bacteria,1MUFR@1224|Proteobacteria,2VM45@28216|Betaproteobacteria,4ABIA@80864|Comamonadaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_6169187_15	926554.KI912664_gene1577	7.181e-28	127.0	29XYR@1|root,30JRD@2|Bacteria,1WNBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
HFD2_k127_6169187_17	479433.Caci_7346	2.134e-15	87.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_6169187_2	1265502.KB905948_gene1024	1.748e-199	649.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,4A9N6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD2_k127_6169187_14	857087.Metme_3234	1.854e-32	141.0	COG2815@1|root,COG2815@2|Bacteria,1PGWR@1224|Proteobacteria,1SSGV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HFD2_k127_6169187_9	1163409.UUA_16148	8.284e-112	389.0	28I8G@1|root,2Z8BA@2|Bacteria,1MWYF@1224|Proteobacteria,1RTN9@1236|Gammaproteobacteria,1X83I@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6169187_1	864051.BurJ1DRAFT_4513	4.429e-217	689.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1KJ7G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_6169187_7	1031711.RSPO_c01176	2.712e-157	507.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,1K086@119060|Burkholderiaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, B subunit	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD2_k127_6169187_8	983917.RGE_44360	6.161e-153	499.0	COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,2VK22@28216|Betaproteobacteria,1KK1A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Domain of unknown function (DUF3391)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
HFD2_k127_6169187_0	864051.BurJ1DRAFT_4511	5.353e-220	714.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJDR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,SBP_bac_3
HFD2_k127_6169187_5	1265502.KB905948_gene978	3.707e-174	559.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,4AA3P@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	mmaA3	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD2_k127_6169187_13	420662.Mpe_A0332	1.17e-37	149.0	2E54A@1|root,32ZX9@2|Bacteria,1N8HJ@1224|Proteobacteria,2VVW9@28216|Betaproteobacteria,1KMNY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
HFD2_k127_6169187_10	1265502.KB905948_gene980	1.362e-107	352.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,4ADIA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	bbsI	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD2_k127_6169187_11	420662.Mpe_A0330	4.422e-86	301.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,1KKM9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	phosphoglycerate mutase	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD2_k127_6169187_6	420662.Mpe_A0329	7.564e-159	509.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2VIUU@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Alanine racemase	-	-	4.1.2.42	ko:K19967	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
HFD2_k127_6169187_4	1265502.KB905948_gene982	1.83e-176	558.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2VJ4E@28216|Betaproteobacteria,4ABMB@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase,YhhN
HFD2_k127_6169187_3	1157708.KB907457_gene2752	5.694e-194	615.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,4A9VT@80864|Comamonadaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HFD2_k127_6192875_0	1265502.KB905974_gene579	9.183e-205	646.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,4ABH0@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD2_k127_6192875_4	1265502.KB905969_gene1240	2.266e-56	199.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,4ADZP@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Thioredoxin domain	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HFD2_k127_6192875_1	420662.Mpe_A3697	1.546e-76	264.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,1KKWU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD2_k127_6192875_2	864051.BurJ1DRAFT_4989	4.677e-58	209.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,1KMKJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_6192875_3	864051.BurJ1DRAFT_4988	6.166e-57	209.0	COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria,1KMGD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	transmembrane transcriptional regulator (Anti-sigma factor)	prtR	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_6194001_2	477184.KYC_01879	4.182e-117	384.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,2WH6C@28216|Betaproteobacteria,3T8W3@506|Alcaligenaceae	28216|Betaproteobacteria	U	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD2_k127_6194001_4	1265502.KB905962_gene360	2.563e-94	319.0	COG0583@1|root,COG0583@2|Bacteria,1R74J@1224|Proteobacteria,2VNHS@28216|Betaproteobacteria,4AAX6@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6194001_6	1123487.KB892842_gene4150	2.552e-63	220.0	COG0446@1|root,COG0446@2|Bacteria,1QU0H@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HFD2_k127_6194001_3	1304878.AUGD01000022_gene3716	1.104e-103	347.0	COG4188@1|root,COG4188@2|Bacteria,1R9J5@1224|Proteobacteria,2UDCI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HFD2_k127_6194001_1	1500301.JQMF01000010_gene2182	5.925e-127	447.0	COG2021@1|root,COG2021@2|Bacteria,1QIH6@1224|Proteobacteria,2TW9Y@28211|Alphaproteobacteria,4BFE2@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD2_k127_6194001_0	1038860.AXAP01000005_gene8085	1.056e-262	835.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JWWK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HFD2_k127_6194001_5	644076.SCH4B_0781	4.413e-72	252.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,4NB3Z@97050|Ruegeria	28211|Alphaproteobacteria	C	Isoquinoline 1-oxidoreductase	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_6194001_7	223283.PSPTO_4068	7.427e-17	81.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RXXK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2207 AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HFD2_k127_6222092_1	420662.Mpe_A1387	4.592e-126	409.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1KIZ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_6222092_2	420662.Mpe_A1388	2.116e-118	388.0	COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2VM8Y@28216|Betaproteobacteria,1KM4T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	ilvR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6222092_0	420662.Mpe_A1389	2.245e-151	481.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,1KJNZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HFD2_k127_6222092_3	420662.Mpe_A2256	2.15e-101	334.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,1KK0B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD2_k127_6224433_0	395495.Lcho_1773	5.233e-156	514.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,1KJ2I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Subtilase family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,Peptidase_S8
HFD2_k127_6224433_2	1123487.KB892835_gene3313	2.858e-84	301.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,2M02Y@206389|Rhodocyclales	28216|Betaproteobacteria	O	Subtilase family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,Peptidase_S8
HFD2_k127_6224433_4	395495.Lcho_0226	4.479e-42	173.0	2DD05@1|root,2ZG0C@2|Bacteria,1RC2B@1224|Proteobacteria,2VQ0R@28216|Betaproteobacteria,1KM8Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6224433_1	983917.RGE_44740	4.904e-92	312.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2VNXD@28216|Betaproteobacteria,1KKV9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HFD2_k127_6224433_3	420662.Mpe_A0264	9.152e-82	276.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1KKW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD2_k127_6224433_5	1265502.KB905952_gene801	4.192e-23	104.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,4AAE2@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA topoisomerase, type IA, central domain protein	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
HFD2_k127_6230112_12	1265502.KB905939_gene2356	1.138e-72	248.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,4AC6Q@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD2_k127_6230112_9	1265502.KB905939_gene2357	9.342e-108	372.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,4AARP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
HFD2_k127_6230112_4	1265502.KB905939_gene2358	7.016e-190	603.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae	28216|Betaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
HFD2_k127_6230112_10	987059.RBXJA2T_02702	2.561e-103	345.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,1KJT9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HFD2_k127_6230112_6	420662.Mpe_A0239	3.06e-167	539.0	COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,1KJG3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6230112_11	864051.BurJ1DRAFT_4625	2.516e-82	282.0	COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria,2VQGV@28216|Betaproteobacteria,1KN5R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HFD2_k127_6230112_13	983917.RGE_13740	1.127e-70	243.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,1KKZY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	aut	-	2.7.7.70	ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_6230112_8	987059.RBXJA2T_02692	3.845e-109	377.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,1KJMA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6230112_14	420662.Mpe_A0241	3.64e-47	177.0	2E0TN@1|root,32WBB@2|Bacteria,1N02C@1224|Proteobacteria,2VUQU@28216|Betaproteobacteria,1KMEF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_6230112_1	864051.BurJ1DRAFT_4622	0.0	1322.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,1KJYU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HFD2_k127_6230112_0	864051.BurJ1DRAFT_4621	0.0	1487.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,1KJV8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HFD2_k127_6230112_7	864051.BurJ1DRAFT_4620	2.779e-114	396.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,1KJD9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	opaA	-	3.5.5.1	ko:K01501,ko:K11206	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD2_k127_6230112_5	1223521.BBJX01000007_gene1432	5.357e-181	573.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,4ACNH@80864|Comamonadaceae	28216|Betaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_6230112_3	595537.Varpa_2456	4.617e-313	968.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HFD2_k127_6230112_2	1123073.KB899242_gene1461	5.889e-314	969.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1XA61@135614|Xanthomonadales	135614|Xanthomonadales	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
HFD2_k127_6236375_1	338969.Rfer_3280	2.518e-160	539.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,2VJ0R@28216|Betaproteobacteria,4AC30@80864|Comamonadaceae	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HFD2_k127_6236375_0	338969.Rfer_3279	2.995e-189	613.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria,4ADDM@80864|Comamonadaceae	1224|Proteobacteria	C	Proton-conducting membrane transporter	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Proton_antipo_M,Proton_antipo_N
HFD2_k127_6236375_3	338969.Rfer_3278	2.018e-54	212.0	295Z9@1|root,2ZTA1@2|Bacteria,1P4NQ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD2_k127_6236375_2	338969.Rfer_3277	2.223e-112	376.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2VKBD@28216|Betaproteobacteria,4AB8E@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HFD2_k127_6236375_4	338969.Rfer_3276	2.828e-49	177.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,4ACA2@80864|Comamonadaceae	1224|Proteobacteria	C	Proton-conducting membrane transporter	ehrA-1	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HFD2_k127_6237214_5	1071679.BG57_23385	1.785e-18	91.0	COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,2WF99@28216|Betaproteobacteria,1KHZQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	-	-	-	-	-	-	-	-	-	T6SS_HCP
HFD2_k127_6237214_0	1123504.JQKD01000008_gene5439	3.615e-274	848.0	COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,2VKCP@28216|Betaproteobacteria,4A9SR@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM type VI secretion protein, EvpB VC_A0108 family	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
HFD2_k127_6237214_1	62928.azo3895	1.274e-85	286.0	COG3516@1|root,COG3516@2|Bacteria,1RAZQ@1224|Proteobacteria,2VQ4P@28216|Betaproteobacteria,2KZTV@206389|Rhodocyclales	206389|Rhodocyclales	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
HFD2_k127_6237214_3	62928.azo3894	6.938e-62	226.0	COG3515@1|root,COG3515@2|Bacteria,1NK35@1224|Proteobacteria,2VQ1C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM type VI secretion-associated protein, ImpA family	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N
HFD2_k127_6237214_2	375286.mma_1617	1.948e-70	260.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria,476B4@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
HFD2_k127_6237214_4	1349767.GJA_1456	2.028e-50	189.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2VJ6Y@28216|Betaproteobacteria,476AX@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	TIGRFAM filamentous hemagglutinin family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,Glug,Haemagg_act
HFD2_k127_6243880_0	1163617.SCD_n02428	0.0	1583.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
HFD2_k127_6243880_4	420662.Mpe_A1916	1.164e-175	561.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,1KIVF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HFD2_k127_6243880_6	420662.Mpe_A1915	1.242e-116	387.0	COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,2VJ2A@28216|Betaproteobacteria,1KK3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6243880_2	887062.HGR_13454	1.133e-213	670.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VJ0X@28216|Betaproteobacteria,4AD3I@80864|Comamonadaceae	28216|Betaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_6243880_1	887062.HGR_13464	1.894e-267	829.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4AB55@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	puuC	-	1.2.1.54,1.2.1.8,1.2.1.99	ko:K00130,ko:K09472,ko:K12254	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00136,M00555	R02549,R02565,R02566,R03177,R07417,R07418	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_6243880_3	864051.BurJ1DRAFT_2658	4.701e-187	611.0	COG3637@1|root,COG3637@2|Bacteria,1N1WQ@1224|Proteobacteria,2VMY3@28216|Betaproteobacteria,1KJWH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	DUF3138
HFD2_k127_6243880_5	420662.Mpe_A1906	5.105e-130	422.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VHYY@28216|Betaproteobacteria,1KJVC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	transport system permease	potI	-	-	ko:K11074	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
HFD2_k127_6243880_7	420662.Mpe_A1905	1.371e-21	93.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KJGM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	transport system permease	potH	-	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
HFD2_k127_6254775_4	420662.Mpe_A0164	2.687e-167	534.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2VTTR@28216|Betaproteobacteria,1KIVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Tryptophan halogenase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HFD2_k127_6254775_8	448385.sce0907	2.087e-97	344.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,43E8K@68525|delta/epsilon subdivisions,2X9BJ@28221|Deltaproteobacteria,2YXFG@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HFD2_k127_6254775_13	1157708.KB907450_gene6145	1.563e-45	171.0	COG0346@1|root,COG0346@2|Bacteria,1RDNZ@1224|Proteobacteria,2WE8D@28216|Betaproteobacteria,4AJN9@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_6254775_10	1254432.SCE1572_06490	2.044e-65	237.0	COG0122@1|root,COG0350@1|root,COG0122@2|Bacteria,COG0350@2|Bacteria,1MVF7@1224|Proteobacteria,43ARM@68525|delta/epsilon subdivisions,2X65K@28221|Deltaproteobacteria,2Z392@29|Myxococcales	28221|Deltaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,HhH-GPD
HFD2_k127_6254775_0	987059.RBXJA2T_00704	0.0	1205.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJMS@28216|Betaproteobacteria,1KJVP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HFD2_k127_6254775_7	987059.RBXJA2T_00709	2.824e-115	374.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2VI7A@28216|Betaproteobacteria,1KJI8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	dhlB	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HFD2_k127_6254775_3	864051.BurJ1DRAFT_0829	5.155e-168	531.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,1KKCM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator	dmlR2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6254775_14	420662.Mpe_A0155	1.256e-23	117.0	2E4IS@1|root,32ZDU@2|Bacteria,1N7N3@1224|Proteobacteria,2VVSI@28216|Betaproteobacteria,1KMJV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	psiF repeat	psiF	-	-	-	-	-	-	-	-	-	-	-	PsiF_repeat
HFD2_k127_6254775_2	1538295.JY96_12895	1.379e-202	670.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,1KJ5A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
HFD2_k127_6254775_1	420662.Mpe_A0153	1.319e-268	867.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,1KJQ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HFD2_k127_6254775_12	420662.Mpe_A0152	1.071e-56	219.0	COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,1KKS6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Sporulation related domain	ftsN	-	-	-	-	-	-	-	-	-	-	-	SPOR
HFD2_k127_6254775_9	864051.BurJ1DRAFT_0824	2.062e-73	259.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,1KKVA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin
HFD2_k127_6254775_11	987059.RBXJA2T_13249	3.507e-60	216.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VSI4@28216|Betaproteobacteria,1KM9V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HFD2_k127_6254775_6	395495.Lcho_4226	2.633e-120	421.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,1KJJM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_6254775_5	420662.Mpe_A0148	1.43e-136	447.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,1KJHW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD2_k127_6254821_5	1458275.AZ34_15430	1.03e-128	411.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,4A9S3@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD2_k127_6254821_13	748247.AZKH_2093	9.48e-96	342.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_9,Response_reg
HFD2_k127_6254821_14	768671.ThimaDRAFT_3149	2.03e-21	105.0	COG3221@1|root,COG3221@2|Bacteria,1N5FI@1224|Proteobacteria,1SSUB@1236|Gammaproteobacteria,1X1UA@135613|Chromatiales	135613|Chromatiales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
HFD2_k127_6254821_9	395495.Lcho_0583	9.128e-108	358.0	COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,1KK9R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_6254821_3	1268622.AVS7_03091	8.914e-156	502.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2VJY9@28216|Betaproteobacteria,4AAK3@80864|Comamonadaceae	28216|Betaproteobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
HFD2_k127_6254821_15	381666.H16_A0654	4.977e-15	82.0	COG3157@1|root,COG3157@2|Bacteria,1RC6P@1224|Proteobacteria,2VQKT@28216|Betaproteobacteria,1K6SP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	type VI secretion system effector	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD2_k127_6254821_6	864051.BurJ1DRAFT_4716	1.449e-125	426.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2VMDP@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
HFD2_k127_6254821_8	864051.BurJ1DRAFT_4718	5.619e-110	363.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2VI3C@28216|Betaproteobacteria,1KNA0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HFD2_k127_6254821_10	296591.Bpro_1491	1.494e-107	380.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VN5A@28216|Betaproteobacteria,4AC1W@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_6254821_2	595537.Varpa_5382	4.284e-160	510.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,4AASB@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.410	ko:K22025	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HFD2_k127_6254821_7	358220.C380_05275	9.018e-124	404.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,4ABCT@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the hyi family	hyi	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HFD2_k127_6254821_12	279714.FuraDRAFT_3526	1.975e-102	338.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2VMN4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Class II aldolase	fucA	-	4.1.1.104,4.1.2.17	ko:K01628,ko:K22130	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD2_k127_6254821_11	595537.Varpa_5383	6.157e-105	346.0	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,2VZB1@28216|Betaproteobacteria,4ACMQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_6254821_1	595537.Varpa_5384	1.239e-185	599.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4ADBU@80864|Comamonadaceae	28216|Betaproteobacteria	P	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_6254821_0	595537.Varpa_5385	1.173e-231	743.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VJYY@28216|Betaproteobacteria,4ACCN@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_6254821_4	864051.BurJ1DRAFT_0686	2.453e-145	468.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,1KKBG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HFD2_k127_6263963_0	1157708.KB907473_gene1252	6.67e-267	824.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,4A9QR@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HFD2_k127_6263963_4	1223521.BBJX01000014_gene292	3.957e-114	397.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2VIIF@28216|Betaproteobacteria,4A9UA@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_6263963_7	420662.Mpe_A1608	5.953e-11	75.0	COG2104@1|root,COG2104@2|Bacteria,1PQBC@1224|Proteobacteria,2W9MX@28216|Betaproteobacteria,1KMRE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD2_k127_6263963_2	420662.Mpe_A1607	7.619e-134	436.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,1KIVS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HFD2_k127_6263963_1	420662.Mpe_A1606	5.828e-189	621.0	COG0351@1|root,COG0352@1|root,COG0351@2|Bacteria,COG0352@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,1KIVC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Thiamine monophosphate synthase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,TMP-TENI
HFD2_k127_6263963_5	365046.Rta_23250	2.766e-94	328.0	COG0265@1|root,COG0265@2|Bacteria,1N58P@1224|Proteobacteria,2VS6N@28216|Betaproteobacteria,4AHSM@80864|Comamonadaceae	28216|Betaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_6263963_6	983917.RGE_34900	4.421e-69	241.0	COG1670@1|root,COG1670@2|Bacteria,1RH19@1224|Proteobacteria,2WH71@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HFD2_k127_6263963_3	420662.Mpe_A2323	1.12e-129	417.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1KJ90@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD2_k127_6283932_5	1121035.AUCH01000008_gene1041	7.469e-11	64.0	COG3011@1|root,COG3011@2|Bacteria,1N6AW@1224|Proteobacteria,2VXY1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HFD2_k127_6283932_4	1121015.N789_11940	6.729e-68	235.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1X78I@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD2_k127_6283932_1	395495.Lcho_1827	2.859e-111	365.0	2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,1KPCW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
HFD2_k127_6283932_2	1265502.KB905942_gene2799	1.043e-107	376.0	COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HFD2_k127_6283932_0	987059.RBXJA2T_15133	4.906e-138	465.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2VJES@28216|Betaproteobacteria	28216|Betaproteobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HFD2_k127_6283932_6	469383.Cwoe_3360	7.983e-08	64.0	COG2132@1|root,COG3386@1|root,COG2132@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	1.7.2.1	ko:K00368,ko:K07004	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	ASH,Copper-bind,Cu-oxidase_2,Cu-oxidase_3,DUF3739,Haemagg_act,MRJP,SGL
HFD2_k127_6283932_3	983917.RGE_11090	2.615e-83	280.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2VJ3Q@28216|Betaproteobacteria,1KK9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA ligase N terminus	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD2_k127_6314571_6	420662.Mpe_A2100	1.494e-122	400.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HFD2_k127_6314571_4	420662.Mpe_A2099	2.757e-131	431.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,1KIV2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_6314571_7	1538295.JY96_02980	8.298e-120	407.0	28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,2VI32@28216|Betaproteobacteria,1KIXD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TIGRFAM TIGR03790 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6314571_5	395495.Lcho_2550	1.377e-126	432.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,1KJUT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Flavin containing amine oxidoreductase	hpnE	-	1.17.8.1	ko:K21677	-	-	-	-	ko00000,ko01000	-	-	-	Amino_oxidase
HFD2_k127_6314571_2	395495.Lcho_2549	3.864e-151	485.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,1KIZ1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	PFAM Squalene phytoene synthase	hpnD	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_6314571_8	420662.Mpe_A1288	2.436e-107	356.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,1KITY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnC	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HFD2_k127_6314571_3	420662.Mpe_A1289	3.843e-134	440.0	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1KK79@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_6314571_0	1265502.KB905935_gene3121	0.0	1592.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,4AC02@80864|Comamonadaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD2_k127_6314571_1	1265502.KB905935_gene3120	6.2e-217	680.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,4AAXB@80864|Comamonadaceae	28216|Betaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD2_k127_633438_3	1538295.JY96_06015	3.046e-191	605.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,1KJTH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HFD2_k127_633438_17	398578.Daci_2264	7.574e-16	89.0	2DNMK@1|root,32Y4Z@2|Bacteria,1NETN@1224|Proteobacteria,2VW6U@28216|Betaproteobacteria,4AFM4@80864|Comamonadaceae	28216|Betaproteobacteria	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
HFD2_k127_633438_14	864051.BurJ1DRAFT_3782	3.627e-29	129.0	COG5395@1|root,COG5395@2|Bacteria,1N0CF@1224|Proteobacteria,2VSEW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
HFD2_k127_633438_7	196367.JNFG01000198_gene2360	2.343e-91	326.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2VKFT@28216|Betaproteobacteria,1K0JH@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	lytT	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD2_k127_633438_6	864051.BurJ1DRAFT_3783	5.357e-101	350.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VRIK@28216|Betaproteobacteria,1KM69@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HFD2_k127_633438_12	196367.JNFG01000198_gene2363	2.974e-41	159.0	2E50M@1|root,32ZU3@2|Bacteria,1N7SP@1224|Proteobacteria,2VTYV@28216|Betaproteobacteria,1K83Z@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_633438_15	870187.Thini_3922	7.119e-21	98.0	COG1917@1|root,COG1917@2|Bacteria,1NDV4@1224|Proteobacteria,1SU3C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HFD2_k127_633438_13	864051.BurJ1DRAFT_0405	2.697e-32	138.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,1KMJJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_633438_11	1288494.EBAPG3_22700	3.603e-53	205.0	COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,2VSQW@28216|Betaproteobacteria,373UF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
HFD2_k127_633438_2	296591.Bpro_2152	1.588e-199	643.0	COG2866@1|root,COG2866@2|Bacteria,1QHMD@1224|Proteobacteria,2VJZ0@28216|Betaproteobacteria,4ABZZ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD2_k127_633438_18	1286632.P278_08430	9.348e-12	72.0	2DPHC@1|root,32UM4@2|Bacteria,4NT51@976|Bacteroidetes,1I4TT@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_633438_0	864051.BurJ1DRAFT_3780	1.06e-272	846.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,1KJ6Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HFD2_k127_633438_5	987059.RBXJA2T_00235	2.753e-129	416.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2VIA5@28216|Betaproteobacteria,1KKC7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD2_k127_633438_1	1265502.KB905929_gene2231	6.207e-224	703.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,4A9X8@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD2_k127_633438_10	614083.AWQR01000018_gene1782	6.719e-62	237.0	COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,2VT33@28216|Betaproteobacteria,4AEK7@80864|Comamonadaceae	28216|Betaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HFD2_k127_633438_4	420662.Mpe_A1339	1.224e-166	529.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,1KJMH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HFD2_k127_633438_19	395495.Lcho_3806	8.512e-06	58.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,1KJAP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HFD2_k127_633438_8	983917.RGE_38510	6.539e-70	244.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,1KM1Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD2_k127_633438_9	596153.Alide_2152	1.564e-63	222.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,4ADH1@80864|Comamonadaceae	28216|Betaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HFD2_k127_6369547_4	420662.Mpe_A0569	5.133e-27	116.0	COG2882@1|root,COG2882@2|Bacteria,1NARI@1224|Proteobacteria,2VWFF@28216|Betaproteobacteria,1KMPS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	flagellar export protein FliJ	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
HFD2_k127_6369547_0	983917.RGE_16800	2.591e-237	753.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2VHQ5@28216|Betaproteobacteria,1KIVI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD2_k127_6369547_2	1265502.KB905929_gene2148	2.202e-64	229.0	COG1317@1|root,COG1317@2|Bacteria,1NMQE@1224|Proteobacteria,2VSQ0@28216|Betaproteobacteria,4AEPN@80864|Comamonadaceae	28216|Betaproteobacteria	N	flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
HFD2_k127_6369547_1	864051.BurJ1DRAFT_0259	1.775e-167	540.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,1KK1Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	flagellar motor switch protein	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
HFD2_k127_6369547_3	983917.RGE_16830	1.817e-49	181.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2VI9M@28216|Betaproteobacteria,1KJ2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
HFD2_k127_6378947_5	397945.Aave_3018	1.368e-73	249.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,4AAVB@80864|Comamonadaceae	28216|Betaproteobacteria	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD2_k127_6378947_4	395495.Lcho_1904	5.789e-99	329.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2VNKF@28216|Betaproteobacteria,1KKPR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD2_k127_6378947_3	983917.RGE_32780	2.821e-115	377.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2VKM0@28216|Betaproteobacteria,1KJAF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HFD2_k127_6378947_12	1265502.KB905940_gene2953	2.03e-13	76.0	2EPZS@1|root,33HK8@2|Bacteria,1NHFB@1224|Proteobacteria,2VY6T@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6378947_7	748247.AZKH_3332	4.871e-57	213.0	COG2059@1|root,COG2059@2|Bacteria,1RAZW@1224|Proteobacteria,2VQ9R@28216|Betaproteobacteria,2KW68@206389|Rhodocyclales	206389|Rhodocyclales	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_6378947_9	760117.JN27_04875	8.687e-52	206.0	COG2059@1|root,COG2059@2|Bacteria,1MZHQ@1224|Proteobacteria,2VQS5@28216|Betaproteobacteria,47430@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD2_k127_6378947_2	1265502.KB905940_gene2954	1.914e-144	484.0	COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,2VITW@28216|Betaproteobacteria,4AD7H@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.65	-	-	MFS_1
HFD2_k127_6378947_1	864051.BurJ1DRAFT_1971	2.015e-187	590.0	COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2VHIZ@28216|Betaproteobacteria,1KJI5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_6378947_6	420662.Mpe_A1821	1.509e-57	205.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2VS54@28216|Betaproteobacteria,1KM4Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HFD2_k127_6378947_8	316055.RPE_0702	9.45e-53	192.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2TVFG@28211|Alphaproteobacteria,3JS2P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	LysE type translocator	MA20_22020	-	-	-	-	-	-	-	-	-	-	-	LysE
HFD2_k127_6378947_13	864051.BurJ1DRAFT_1973	4.902e-10	69.0	2FKW3@1|root,34CGE@2|Bacteria,1P9MH@1224|Proteobacteria,2W6E9@28216|Betaproteobacteria,1KP7E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6378947_11	864051.BurJ1DRAFT_1974	2.739e-15	91.0	29042@1|root,2ZMU1@2|Bacteria,1PABH@1224|Proteobacteria,2W5HD@28216|Betaproteobacteria,1KP4K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6378947_0	1265502.KB905940_gene2956	0.0	1053.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,4AB5A@80864|Comamonadaceae	28216|Betaproteobacteria	S	peptidase S45, penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD2_k127_6378947_10	864051.BurJ1DRAFT_1976	9.215e-26	107.0	2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,2VW65@28216|Betaproteobacteria,1KMGW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pathogenicity locus	mcrB	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	Cdd1
HFD2_k127_6381617_3	1265502.KB905931_gene1739	7.002e-187	587.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2VJH9@28216|Betaproteobacteria,4AAPF@80864|Comamonadaceae	28216|Betaproteobacteria	EH	PFAM phosphoadenosine phosphosulfate reductase	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD2_k127_6381617_1	1265502.KB905931_gene1738	1.726e-224	702.0	COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,4A9K7@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU,GTP_EFTU_D2
HFD2_k127_6381617_4	1265502.KB905931_gene1737	2.372e-103	341.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,4AAU2@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
HFD2_k127_6381617_5	1538295.JY96_20515	1.794e-60	211.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1KM2U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_10,Fer4_4
HFD2_k127_6381617_2	420662.Mpe_A1496	2.326e-210	657.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,1KJ6X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Ferredoxin--NADP reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HFD2_k127_6381617_0	1265502.KB905931_gene1734	8.727e-243	771.0	COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,2VH0X@28216|Betaproteobacteria,4AEMG@80864|Comamonadaceae	28216|Betaproteobacteria	P	TonB dependent receptor	fatA1	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_6411846_10	365046.Rta_31300	3e-70	240.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4ABN3@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	ugpC	-	3.6.3.20	ko:K05816,ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
HFD2_k127_6411846_7	987059.RBXJA2T_07025	6.508e-140	449.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,1KMFN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
HFD2_k127_6411846_5	338969.Rfer_1286	4.507e-150	480.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VH0I@28216|Betaproteobacteria,4ACEG@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ugpA	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HFD2_k127_6411846_2	1268622.AVS7_03015	1.81e-250	782.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2VH0F@28216|Betaproteobacteria,4AA3S@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM extracellular solute-binding protein family 1	ugpB	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HFD2_k127_6411846_0	1265502.KB905942_gene2844	0.0	2197.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,4A9NT@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
HFD2_k127_6411846_4	983917.RGE_11710	5.776e-175	556.0	COG0075@1|root,COG0075@2|Bacteria,1PM38@1224|Proteobacteria,2VHNM@28216|Betaproteobacteria,1KJ8J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD2_k127_6411846_1	1286631.X805_30320	1.716e-268	854.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,1KN13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD2_k127_6411846_6	1278073.MYSTI_04407	2.067e-147	505.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_6411846_3	296591.Bpro_2812	1.658e-176	557.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHND@28216|Betaproteobacteria,4ADJK@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_6411846_9	296591.Bpro_2813	7.486e-130	457.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VHX8@28216|Betaproteobacteria,4AD2R@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppC	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_6411846_8	1157708.KB907455_gene3335	7.523e-139	464.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4AA2A@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K12371	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_6412142_2	864051.BurJ1DRAFT_1252	3.25e-132	426.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1KKEZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816,ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
HFD2_k127_6412142_3	987059.RBXJA2T_07015	2.992e-106	359.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2VKF6@28216|Betaproteobacteria,1KJVZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_6412142_5	1347087.CBYO010000009_gene1421	8.573e-51	188.0	COG1670@1|root,COG1670@2|Bacteria,1V26J@1239|Firmicutes,4HG0M@91061|Bacilli	91061|Bacilli	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_6412142_1	983917.RGE_10580	5.386e-187	595.0	COG0477@1|root,COG2814@2|Bacteria,1R3YS@1224|Proteobacteria,2VQBS@28216|Betaproteobacteria,1KNDV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6412142_6	522306.CAP2UW1_1126	8.992e-46	176.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,2VTPY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6412142_0	1286631.X805_38880	9.16e-199	630.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KJ4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD2_k127_6412142_4	987059.RBXJA2T_06995	7.499e-74	249.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KITH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD2_k127_6417517_6	864051.BurJ1DRAFT_4285	6.002e-12	65.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,1KKHC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HFD2_k127_6417517_4	420662.Mpe_A0280	6.112e-70	245.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,2VRJF@28216|Betaproteobacteria,1KKTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
HFD2_k127_6417517_1	1265502.KB905960_gene309	3.2e-143	463.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,4A9WF@80864|Comamonadaceae	28216|Betaproteobacteria	LU	DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD2_k127_6417517_0	1538295.JY96_13385	1.783e-163	526.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,1KJD1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD2_k127_6417517_3	420662.Mpe_A0283	2.258e-81	275.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,1KKJ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD2_k127_6417517_2	358220.C380_23005	2.014e-135	437.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,4AC2V@80864|Comamonadaceae	28216|Betaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD2_k127_6417517_5	1538295.JY96_13370	1.223e-46	171.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,1KJAQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD2_k127_6459435_22	395495.Lcho_3605	4.366e-50	181.0	COG0001@1|root,COG0001@2|Bacteria,1QVPQ@1224|Proteobacteria,2WHQE@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_6459435_10	395495.Lcho_3604	3.202e-142	457.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VH0R@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Phosphatidylserine decarboxylase	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD2_k127_6459435_19	864051.BurJ1DRAFT_1407	1.828e-75	272.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VUP7@28216|Betaproteobacteria,1KNNZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	TIGRFAM diguanylate cyclase	-	-	2.7.7.65	ko:K13069,ko:K21085	ko02026,map02026	-	R08057	-	ko00000,ko00001,ko01000	-	-	-	CHASE7,GGDEF,HAMP
HFD2_k127_6459435_5	1387312.BAUS01000002_gene816	3.025e-217	692.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KNHX@206350|Nitrosomonadales	206350|Nitrosomonadales	P	K+ potassium transporter	-	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HFD2_k127_6459435_8	543728.Vapar_3587	4.627e-165	526.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,4ACUI@80864|Comamonadaceae	28216|Betaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD2_k127_6459435_14	614083.AWQR01000047_gene3297	1.118e-104	344.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,4AAVM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_6459435_0	420662.Mpe_A2503	0.0	1105.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2VH62@28216|Betaproteobacteria,1KKH3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HFD2_k127_6459435_18	365044.Pnap_3602	1.275e-76	261.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2VQ72@28216|Betaproteobacteria,4ADFT@80864|Comamonadaceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HFD2_k127_6459435_1	420662.Mpe_A2506	0.0	1058.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2VH26@28216|Betaproteobacteria,1KKG4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HFD2_k127_6459435_2	365044.Pnap_3604	1.395e-284	886.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2VI68@28216|Betaproteobacteria,4ACPU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HFD2_k127_6459435_21	1211114.ALIP01000094_gene1207	1.494e-52	189.0	COG0789@1|root,COG0789@2|Bacteria,1RH2U@1224|Proteobacteria,1S6M0@1236|Gammaproteobacteria,1X746@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	soxR	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind
HFD2_k127_6459435_11	243365.CV_3243	1.436e-118	396.0	COG0477@1|root,COG2814@2|Bacteria,1MX1Q@1224|Proteobacteria,2VP0J@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6459435_13	316067.Geob_3759	1.678e-116	383.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HFD2_k127_6459435_3	395495.Lcho_1674	4.263e-232	727.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,1KJ9U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HFD2_k127_6459435_9	1265502.KB905930_gene1489	3.357e-143	467.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,4AA87@80864|Comamonadaceae	28216|Betaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HFD2_k127_6459435_7	1265502.KB905930_gene1488	5.453e-188	591.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,4AA05@80864|Comamonadaceae	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HFD2_k127_6459435_12	864051.BurJ1DRAFT_2100	9.766e-118	386.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1KJ78@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	endonuclease III	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD2_k127_6459435_4	1265502.KB905930_gene1486	8.302e-231	723.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,4ABUH@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HFD2_k127_6459435_23	365046.Rta_15390	2.211e-43	168.0	COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,4AB2J@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8
HFD2_k127_6459435_20	1538295.JY96_20660	3.837e-74	264.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,1KKPY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD2_k127_6459435_17	1538295.JY96_20655	3.957e-79	267.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KKMR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HFD2_k127_6459435_16	420662.Mpe_A2459	9.201e-96	329.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,2VQRP@28216|Betaproteobacteria,1KKK0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
HFD2_k127_6459435_15	1265502.KB905930_gene1481	6.974e-96	334.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria,4ACNB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the MtfA family	mtfA	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
HFD2_k127_6459435_6	420662.Mpe_A2461	4.418e-199	622.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,1KK7T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD2_k127_650990_5	1286631.X805_31530	6.967e-34	134.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,1KM46@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HFD2_k127_650990_4	420662.Mpe_A1013	3.505e-95	317.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,2VN1E@28216|Betaproteobacteria,1KJZK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_650990_0	420662.Mpe_A1014	0.0	1255.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase	icmF	-	5.4.99.2,5.4.99.64	ko:K01847,ko:K20906	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HFD2_k127_650990_3	1123504.JQKD01000029_gene4178	8.259e-131	436.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,4AA9Q@80864|Comamonadaceae	28216|Betaproteobacteria	E	LAO AO transport system ATPase	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD2_k127_650990_1	338969.Rfer_2803	1.956e-317	974.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,4AAS7@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD2_k127_650990_2	987059.RBXJA2T_03391	1.23e-194	610.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1KJ3N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HFD2_k127_6532921_5	864051.BurJ1DRAFT_3503	2.071e-78	263.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,1KK0W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HFD2_k127_6532921_3	983917.RGE_31920	6.075e-112	363.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1KJRV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome C oxidase	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HFD2_k127_6532921_7	983917.RGE_31910	9.319e-12	66.0	COG4736@1|root,COG4736@2|Bacteria,1PUF6@1224|Proteobacteria,2VXME@28216|Betaproteobacteria,1KMUA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Cbb3-type cytochrome oxidase	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HFD2_k127_6532921_1	983917.RGE_31900	4.487e-137	443.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,1KJR0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HFD2_k127_6532921_0	1265502.KB905930_gene1471	3.827e-231	725.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HFD2_k127_6532921_6	395495.Lcho_2773	2.903e-20	98.0	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,2VU0U@28216|Betaproteobacteria,1KMSH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6532921_2	864051.BurJ1DRAFT_3496	4.028e-125	405.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,1KJZH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_6532921_4	983917.RGE_31850	3.17e-101	338.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1KJPR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD2_k127_656323_2	1286631.X805_05220	5.306e-88	294.0	COG3509@1|root,COG3509@2|Bacteria,1QW8F@1224|Proteobacteria,2WI78@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HFD2_k127_656323_4	991905.SL003B_1296	3.042e-49	179.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2U5SV@28211|Alphaproteobacteria,4BSBP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	MA20_29855	-	-	ko:K09021	ko00240,ko01100,map00240,map01100	-	R09982	RC02768	ko00000,ko00001	-	-	-	Ribonuc_L-PSP
HFD2_k127_656323_6	261292.Nit79A3_0363	1.22e-24	114.0	2EE49@1|root,337YY@2|Bacteria,1NE01@1224|Proteobacteria,2WGY9@28216|Betaproteobacteria,3736S@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HFD2_k127_656323_7	318161.Sden_1464	6.344e-18	94.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,2QE2W@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_656323_1	864051.BurJ1DRAFT_1722	1.123e-117	383.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2VKM0@28216|Betaproteobacteria,1KJJU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HFD2_k127_656323_0	136993.KB900626_gene661	8.177e-215	676.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,36XST@31993|Methylocystaceae	28211|Alphaproteobacteria	M	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HFD2_k127_656323_5	864051.BurJ1DRAFT_1723	1.221e-38	146.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VXHZ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM ATP synthase, F0	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_C
HFD2_k127_656323_8	864051.BurJ1DRAFT_4704	2.976e-05	46.0	COG3181@1|root,COG3181@2|Bacteria,1NEU9@1224|Proteobacteria,2VHYX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_656323_3	864051.BurJ1DRAFT_4704	1.252e-82	280.0	COG3181@1|root,COG3181@2|Bacteria,1NEU9@1224|Proteobacteria,2VHYX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_6573829_2	864051.BurJ1DRAFT_3328	2.853e-85	283.0	COG0446@1|root,COG0446@2|Bacteria,1QSG7@1224|Proteobacteria,2W9DB@28216|Betaproteobacteria,1KKDR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_6573829_4	395495.Lcho_3745	4.028e-32	127.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria,1KMH1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HFD2_k127_6573829_1	864051.BurJ1DRAFT_0223	3.044e-102	343.0	COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2VKP1@28216|Betaproteobacteria,1KJCH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
HFD2_k127_6573829_5	864051.BurJ1DRAFT_4921	9.725e-27	124.0	COG1937@1|root,COG1937@2|Bacteria,1PUF5@1224|Proteobacteria,2VVJA@28216|Betaproteobacteria,1KMC3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
HFD2_k127_6573829_6	420662.Mpe_A0095	5.133e-24	104.0	2END2@1|root,33G0J@2|Bacteria,1NIFI@1224|Proteobacteria,2VVU7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6573829_3	864051.BurJ1DRAFT_3789	2.32e-41	167.0	COG2343@1|root,COG2343@2|Bacteria,1N1K4@1224|Proteobacteria,2VU8K@28216|Betaproteobacteria,1KME9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HFD2_k127_6573829_0	395495.Lcho_1775	3.498e-119	393.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,1KK0E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Helix-turn-helix type 11	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HFD2_k127_6586380_7	983917.RGE_29120	2.83e-23	110.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KJ43@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_6586380_8	395495.Lcho_2593	1.558e-17	93.0	29DVA@1|root,300T7@2|Bacteria,1PRFT@1224|Proteobacteria,2W9WB@28216|Betaproteobacteria,1KP2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6586380_5	1286631.X805_40440	9.418e-42	158.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria,1KMAD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase III, chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HFD2_k127_6586380_0	420662.Mpe_A1942	6.254e-219	691.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,1KJV6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD2_k127_6586380_1	983917.RGE_29150	3.415e-149	480.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,1KJUE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Permease, YjgP YjgQ	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD2_k127_6586380_3	987059.RBXJA2T_03768	6.229e-70	269.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,1KJB9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Permease, YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD2_k127_6586380_4	420662.Mpe_A1944	6.295e-66	227.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,1KJB9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Permease, YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD2_k127_6586380_6	987059.RBXJA2T_03773	3.944e-36	146.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,1KMFU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CbiX	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HFD2_k127_6586380_2	1265502.KB905930_gene1510	3.969e-115	381.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,4A9K9@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6598147_4	987059.RBXJA2T_17926	2.595e-13	70.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,1KKMF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HFD2_k127_6598147_2	420662.Mpe_A1993	6.943e-153	494.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,1KK5S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HFD2_k127_6598147_0	1265502.KB905935_gene3060	6.172e-240	747.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,4ACK5@80864|Comamonadaceae	28216|Betaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD2_k127_6598147_3	420662.Mpe_A1991	2.642e-42	156.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,1KM9R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HFD2_k127_6598147_1	983917.RGE_27500	1.398e-167	533.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,1KJBX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD2_k127_66171_0	864051.BurJ1DRAFT_4285	0.0	1024.0	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,2VNCR@28216|Betaproteobacteria,1KKHC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HFD2_k127_66171_3	420662.Mpe_A0278	1.282e-161	514.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,1KJQZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD2_k127_66171_1	420662.Mpe_A0277	0.0	1002.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KJEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
HFD2_k127_66171_5	1265502.KB905960_gene314	2.847e-43	163.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,4AEH1@80864|Comamonadaceae	28216|Betaproteobacteria	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD2_k127_66171_4	644801.Psest_0886	1.011e-152	495.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1Z41B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HFD2_k127_66171_6	1182590.BN5_02457	1.893e-42	166.0	COG1359@1|root,COG1359@2|Bacteria,1N1AN@1224|Proteobacteria,1S750@1236|Gammaproteobacteria,1YK4U@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_66171_7	296591.Bpro_0909	1.069e-19	97.0	COG3905@1|root,COG3905@2|Bacteria,1N7D2@1224|Proteobacteria,2VW4A@28216|Betaproteobacteria	28216|Betaproteobacteria	K	copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HFD2_k127_66171_2	338969.Rfer_3276	2.333e-250	786.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,4ACA2@80864|Comamonadaceae	1224|Proteobacteria	C	Proton-conducting membrane transporter	ehrA-1	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HFD2_k127_6621672_0	1265502.KB905940_gene3012	0.0	2159.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,4AARH@80864|Comamonadaceae	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HFD2_k127_6621672_2	864051.BurJ1DRAFT_2256	2.669e-158	500.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,1KJMF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Methionine aminopeptidase	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD2_k127_6621672_1	1265502.KB905940_gene3014	2.567e-203	656.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,4AA9J@80864|Comamonadaceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
HFD2_k127_6682243_4	1472716.KBK24_0123230	2.483e-14	76.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VICR@28216|Betaproteobacteria,1K078@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM Dimethylmenaquinone methyltransferase	ligK	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HFD2_k127_6682243_0	196367.JNFG01000199_gene3350	4.349e-208	648.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,1K13V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.46,4.2.1.83	ko:K10220,ko:K14333	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R04478	RC00390,RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_6682243_3	358220.C380_22730	2.308e-89	301.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2VJ7W@28216|Betaproteobacteria,4ADRM@80864|Comamonadaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD2_k127_6682243_2	864051.BurJ1DRAFT_2568	1.056e-107	374.0	COG0583@1|root,COG0583@2|Bacteria,1MXR1@1224|Proteobacteria,2VHKB@28216|Betaproteobacteria,1KJPG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K19338	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6682243_1	1538295.JY96_16330	1.114e-121	416.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,1KJU4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD2_k127_6704833_10	864051.BurJ1DRAFT_1016	1.351e-52	186.0	2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,2VQYS@28216|Betaproteobacteria,1KKN1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Nitrogen fixation protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF269
HFD2_k127_6704833_13	864051.BurJ1DRAFT_1015	5.135e-23	99.0	COG5420@1|root,COG5420@2|Bacteria,1N74Y@1224|Proteobacteria,2VVVF@28216|Betaproteobacteria,1KMK9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Rop-like	-	-	-	-	-	-	-	-	-	-	-	-	Rop-like
HFD2_k127_6704833_8	864051.BurJ1DRAFT_1014	1.437e-54	195.0	COG1143@1|root,COG1143@2|Bacteria,1N1SG@1224|Proteobacteria,2VT6Z@28216|Betaproteobacteria,1KM7V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	fdxB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
HFD2_k127_6704833_9	983917.RGE_43010	7.169e-53	195.0	2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,2VUB3@28216|Betaproteobacteria,1KMBK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NifQ	nifQ	-	-	ko:K15790	-	-	-	-	ko00000	-	-	-	NifQ
HFD2_k127_6704833_1	395495.Lcho_1360	1.041e-223	698.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1KJQM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_6704833_5	395495.Lcho_1361	3.06e-73	249.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1KKKU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_6704833_6	1286631.X805_34980	1.924e-61	222.0	COG0316@1|root,COG0316@2|Bacteria,1RFUG@1224|Proteobacteria,2VRJB@28216|Betaproteobacteria,1KKSM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
HFD2_k127_6704833_11	395495.Lcho_1363	2.104e-51	183.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSSY@28216|Betaproteobacteria,1KM8A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD2_k127_6704833_0	1286631.X805_34960	7.223e-289	898.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,1KJI3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
HFD2_k127_6704833_7	864051.BurJ1DRAFT_1005	3.78e-59	208.0	COG0633@1|root,COG0633@2|Bacteria,1RJHP@1224|Proteobacteria,2VSHP@28216|Betaproteobacteria,1KM2C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Ferredoxin, 2Fe-2S type, ISC system	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HFD2_k127_6704833_3	864051.BurJ1DRAFT_1004	8.07e-172	546.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VIRD@28216|Betaproteobacteria,1KJ3D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	nifV	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
HFD2_k127_6704833_12	864051.BurJ1DRAFT_1003	2.69e-40	167.0	2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria,1KM6Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	May protect the nitrogenase Fe-Mo protein from oxidative damage	nifW	-	-	ko:K02595	-	-	-	-	ko00000	-	-	-	NifW
HFD2_k127_6704833_4	987059.RBXJA2T_04438	9.262e-166	532.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VN3Q@28216|Betaproteobacteria,1KK3Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Electron transfer flavoprotein	fixA	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD2_k127_6704833_2	864051.BurJ1DRAFT_1001	1.394e-207	649.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VJWA@28216|Betaproteobacteria,1KJHZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	fixB	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD2_k127_6719268_0	543728.Vapar_6248	2.342e-153	490.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,4A9TI@80864|Comamonadaceae	28216|Betaproteobacteria	KQ	GAF modulated sigma54 specific transcriptional regulator, Fis family	acoR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
HFD2_k127_6719268_3	864051.BurJ1DRAFT_1105	6.826e-86	305.0	COG0811@1|root,COG0811@2|Bacteria,1PPAP@1224|Proteobacteria,2VUN4@28216|Betaproteobacteria,1KMAW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HFD2_k127_6719268_1	864051.BurJ1DRAFT_1104	5.143e-107	355.0	28NA5@1|root,2ZBDZ@2|Bacteria,1MXY5@1224|Proteobacteria,2VMFN@28216|Betaproteobacteria,1KKFX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6719268_4	864051.BurJ1DRAFT_1103	1.413e-71	256.0	2E53F@1|root,32ZWJ@2|Bacteria,1N6KB@1224|Proteobacteria,2VRMT@28216|Betaproteobacteria,1KM01@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6719268_2	395495.Lcho_1800	5.418e-88	306.0	2CWJC@1|root,32SZT@2|Bacteria,1N5QU@1224|Proteobacteria,2VPCS@28216|Betaproteobacteria,1KKF9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6719268_6	420662.Mpe_A2525	7.128e-51	186.0	COG2010@1|root,COG2010@2|Bacteria,1RG8M@1224|Proteobacteria,2VS50@28216|Betaproteobacteria,1KKX0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_6719268_5	1254432.SCE1572_00510	7.275e-59	213.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42PYD@68525|delta/epsilon subdivisions,2X02K@28221|Deltaproteobacteria,2Z0PX@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
HFD2_k127_6739634_3	864051.BurJ1DRAFT_4476	4.175e-71	243.0	COG0457@1|root,COG0457@2|Bacteria,1R3PT@1224|Proteobacteria,2VN88@28216|Betaproteobacteria,1KKRT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6739634_2	420662.Mpe_A0825	2.56e-115	374.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,2VIDN@28216|Betaproteobacteria,1KKHE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HFD2_k127_6739634_0	983917.RGE_08530	5.332e-154	491.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1KJUB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ABC transporter	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6739634_1	1286631.X805_28380	4.756e-127	427.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,1KJBM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD2_k127_6752491_2	864051.BurJ1DRAFT_1806	5.084e-86	286.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,2VNPT@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the xylose isomerase family	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_6752491_0	1458275.AZ34_10220	7.211e-191	608.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VI4Z@28216|Betaproteobacteria,4ADAA@80864|Comamonadaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HFD2_k127_6752491_1	864051.BurJ1DRAFT_1807	8.518e-167	530.0	COG1879@1|root,COG1879@2|Bacteria,1NZGQ@1224|Proteobacteria,2VJKK@28216|Betaproteobacteria,1KN3V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
HFD2_k127_6752491_5	543728.Vapar_1636	8.183e-35	139.0	COG0810@1|root,COG0810@2|Bacteria,1RFAG@1224|Proteobacteria,2VRH3@28216|Betaproteobacteria,4AHP2@80864|Comamonadaceae	28216|Betaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
HFD2_k127_6752491_4	420662.Mpe_A3047	3.673e-73	251.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,1KKU6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD2_k127_6752491_3	864051.BurJ1DRAFT_3868	9.4e-81	287.0	28NPW@1|root,2ZBPM@2|Bacteria,1RAMG@1224|Proteobacteria,2VQIF@28216|Betaproteobacteria,1KNPY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6752545_3	1157708.KB907450_gene5265	2.314e-101	339.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_6752545_0	543728.Vapar_3215	2.404e-259	806.0	COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2VPPG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD2_k127_6752545_2	543728.Vapar_3214	1.772e-101	359.0	COG1414@1|root,COG1414@2|Bacteria,1MXRJ@1224|Proteobacteria,2VNTJ@28216|Betaproteobacteria,4ADV0@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, IclR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD2_k127_6752545_1	543728.Vapar_3213	2.9e-222	696.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2VISW@28216|Betaproteobacteria,4AHQJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HFD2_k127_6752545_4	1286093.C266_24393	9.681e-61	231.0	COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,2VSAS@28216|Betaproteobacteria,1KBB8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HFD2_k127_675394_3	420662.Mpe_A2047	4.674e-122	402.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1KJGP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_675394_6	1523503.JPMY01000028_gene264	4.012e-57	213.0	COG2207@1|root,COG2207@2|Bacteria,1QTZF@1224|Proteobacteria,1T1IZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HFD2_k127_675394_1	1538295.JY96_03620	1.626e-124	403.0	COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,2VH72@28216|Betaproteobacteria,1KJ9R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_675394_4	864051.BurJ1DRAFT_1489	1.53e-84	285.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,1KJEF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_675394_2	420662.Mpe_A2034	1.238e-122	411.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1KJN5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD2_k127_675394_0	614083.AWQR01000030_gene2779	2.177e-131	447.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VJ74@28216|Betaproteobacteria,4AB8F@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K07552,ko:K18552	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.3	-	-	MFS_1
HFD2_k127_675394_7	1538295.JY96_15015	1.53e-33	134.0	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,2VWT7@28216|Betaproteobacteria,1KMAS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_675394_5	76114.ebA1117	4.841e-63	224.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria,2KXU7@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
HFD2_k127_6760472_5	864051.BurJ1DRAFT_2075	8.943e-93	308.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2WHW4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6760472_7	614083.AWQR01000010_gene1587	9.527e-42	161.0	COG1651@1|root,COG1651@2|Bacteria,1NEFD@1224|Proteobacteria,2VTW6@28216|Betaproteobacteria,4AEEZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Thioredoxin-like domain	dsbG	-	-	ko:K03805	-	-	-	-	ko00000,ko03110	-	-	-	Thioredoxin_2
HFD2_k127_6760472_8	420662.Mpe_A1032	2.23e-41	160.0	2CEXV@1|root,32S0S@2|Bacteria,1MZKB@1224|Proteobacteria,2VU8J@28216|Betaproteobacteria,1KMC0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Type II secretion system protein B	gspB	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	T2SSB
HFD2_k127_6760472_0	420662.Mpe_A1031	9.949e-199	634.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,1KJ25@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Type II secretory pathway, component ExeA	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HFD2_k127_6760472_2	864051.BurJ1DRAFT_2427	5e-127	413.0	COG0834@1|root,COG0834@2|Bacteria,1MVT6@1224|Proteobacteria,2VH1B@28216|Betaproteobacteria,1KK6T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030,ko:K10022	ko02010,map02010	M00235,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.11	-	-	SBP_bac_3
HFD2_k127_6760472_3	395495.Lcho_3210	3.775e-102	339.0	COG0765@1|root,COG0765@2|Bacteria,1MX2Y@1224|Proteobacteria,2VNP0@28216|Betaproteobacteria,1KKF0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD2_k127_6760472_4	887062.HGR_07841	1.003e-95	318.0	COG0765@1|root,COG0765@2|Bacteria,1MVB6@1224|Proteobacteria,2VKX0@28216|Betaproteobacteria,4AB2D@80864|Comamonadaceae	28216|Betaproteobacteria	P	Polar amino acid ABC transporter, inner membrane	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD2_k127_6760472_1	395495.Lcho_3208	1.415e-130	420.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VJ04@28216|Betaproteobacteria,1KPEF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HFD2_k127_6760472_6	1538295.JY96_14060	2.018e-58	211.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria,1KPB6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HFD2_k127_6784682_4	983917.RGE_24300	6.491e-60	207.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,1KM43@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD2_k127_6784682_2	420662.Mpe_A1766	2.369e-99	333.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,1KKPT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HFD2_k127_6784682_5	1265502.KB905940_gene3009	2.497e-31	124.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,4AEZC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HFD2_k127_6784682_0	420662.Mpe_A1764	3.544e-112	369.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,1KJ83@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	peptidylprolyl isomerase	cbf2	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
HFD2_k127_6784682_1	420662.Mpe_A1816	1.502e-108	362.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,1KIVG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	ATPases associated with a variety of cellular activities	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6784682_3	864051.BurJ1DRAFT_2260	5.877e-87	299.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2VRIQ@28216|Betaproteobacteria,1KKPU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HFD2_k127_6794659_1	864051.BurJ1DRAFT_3653	3.546e-320	1007.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria	28216|Betaproteobacteria	C	indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
HFD2_k127_6794659_10	1265502.KB905954_gene436	1.007e-87	323.0	COG0583@1|root,COG0583@2|Bacteria,1PISE@1224|Proteobacteria,2VKB4@28216|Betaproteobacteria,4ACJE@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6794659_6	1265502.KB905974_gene580	1.756e-163	543.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2VKQ7@28216|Betaproteobacteria,4ACCM@80864|Comamonadaceae	28216|Betaproteobacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HFD2_k127_6794659_8	215803.DB30_1490	2.015e-148	488.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3367,DUF5122,HemolysinCabind,NPCBM
HFD2_k127_6794659_3	983917.RGE_08500	1.288e-227	712.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VIJ1@28216|Betaproteobacteria,1KKIM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_6794659_13	864051.BurJ1DRAFT_1189	3.045e-41	154.0	COG4281@1|root,COG4281@2|Bacteria,1MZPP@1224|Proteobacteria,2VUK0@28216|Betaproteobacteria,1KM9E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	acyl-coA-binding protein	acb	-	-	-	-	-	-	-	-	-	-	-	ACBP
HFD2_k127_6794659_12	864051.BurJ1DRAFT_1182	7.216e-45	164.0	2EGJT@1|root,33ABY@2|Bacteria,1NGI4@1224|Proteobacteria,2VX3Y@28216|Betaproteobacteria,1KMI2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HFD2_k127_6794659_7	420662.Mpe_A3087	2.95e-153	496.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,1KKFH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
HFD2_k127_6794659_0	420662.Mpe_A3090	0.0	1164.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,1KJMR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_6794659_4	595537.Varpa_3898	8.91e-171	578.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ABZ4@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_6794659_9	864051.BurJ1DRAFT_1179	8.325e-140	471.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,1KMCB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_6794659_2	983917.RGE_08450	5.343e-231	719.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,1KJJ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_6794659_5	864051.BurJ1DRAFT_1177	1.115e-164	539.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,2VHWB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
HFD2_k127_6794659_11	864051.BurJ1DRAFT_1704	8.07e-67	231.0	COG3409@1|root,COG3409@2|Bacteria,1N4WW@1224|Proteobacteria,2VH9D@28216|Betaproteobacteria,1KJ52@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,PG_binding_1
HFD2_k127_6796304_3	395495.Lcho_0978	6.791e-140	454.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,1KK15@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_6796304_0	1265502.KB905934_gene3193	0.0	1774.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,4ABU6@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD2_k127_6796304_1	1504672.669786338	9.618e-202	636.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,4AB40@80864|Comamonadaceae	28216|Betaproteobacteria	S	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HFD2_k127_6796304_7	420662.Mpe_A2884	2.036e-106	349.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2VKFZ@28216|Betaproteobacteria,1KJYA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
HFD2_k127_6796304_9	1123504.JQKD01000007_gene3306	1.183e-59	214.0	COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,2VTFR@28216|Betaproteobacteria,4ADH2@80864|Comamonadaceae	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HFD2_k127_6796304_8	864051.BurJ1DRAFT_4727	2.382e-80	277.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VK49@28216|Betaproteobacteria,1KPIW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavodoxin domain	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HFD2_k127_6796304_6	420662.Mpe_A2889	4.179e-112	366.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,1KJM5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the pirin family	yhhW_2	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD2_k127_6796304_2	864051.BurJ1DRAFT_3084	4.536e-142	458.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2VJTZ@28216|Betaproteobacteria,1KIT3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	transcriptional regulator	allS_2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6796304_5	1265502.KB905934_gene3197	1.25e-125	425.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,4ABA9@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HFD2_k127_6796304_10	1538295.JY96_20235	5.283e-54	206.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,1KM2Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Peptidyl-prolyl cis-trans	fkpA	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD2_k127_6796304_4	522306.CAP2UW1_0900	2.562e-136	438.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2VMU5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HFD2_k127_6848466_3	1304877.KI519399_gene3573	2.984e-64	222.0	COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,2TT1V@28211|Alphaproteobacteria,3JSR9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	MA20_45025	-	-	-	-	-	-	-	-	-	-	-	PaO,Rieske
HFD2_k127_6848466_2	1123504.JQKD01000025_gene5827	1.378e-87	304.0	COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2VJQW@28216|Betaproteobacteria,4A9JY@80864|Comamonadaceae	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	ko:K11475	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_6848466_1	296591.Bpro_3385	3.823e-115	380.0	COG1018@1|root,COG1018@2|Bacteria,1MU6E@1224|Proteobacteria,2VKIJ@28216|Betaproteobacteria,4A9WY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_6848466_0	358220.C380_22770	3.713e-178	566.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2VJRG@28216|Betaproteobacteria,4AAG7@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular liganD-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_6863492_5	1163409.UUA_01350	1.285e-172	550.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria,1X4QM@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_6863492_11	395495.Lcho_1225	6.564e-132	427.0	COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2VJMU@28216|Betaproteobacteria,1KK0N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	eamA1	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6863492_12	983917.RGE_21750	4.316e-127	426.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2VHU1@28216|Betaproteobacteria,1KKE5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_6863492_14	420662.Mpe_A3051	8.038e-116	389.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VHP3@28216|Betaproteobacteria,1KKA2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_6863492_20	420662.Mpe_A3050	3.969e-35	153.0	2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,2VV11@28216|Betaproteobacteria,1KMDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HFD2_k127_6863492_6	420662.Mpe_A3049	4.238e-170	538.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1KJRU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	alcohol dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD2_k127_6863492_13	414684.RC1_1686	1.346e-125	427.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2U2JX@28211|Alphaproteobacteria,2JRBY@204441|Rhodospirillales	204441|Rhodospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_6863492_0	450851.PHZ_c1067	0.0	1251.0	COG0308@1|root,COG1277@1|root,COG0308@2|Bacteria,COG1277@2|Bacteria,1PTWJ@1224|Proteobacteria,2U237@28211|Alphaproteobacteria,2KG1X@204458|Caulobacterales	204458|Caulobacterales	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HFD2_k127_6863492_17	420662.Mpe_A3342	5.76e-78	268.0	COG4372@1|root,COG4372@2|Bacteria,1RKIE@1224|Proteobacteria,2VSID@28216|Betaproteobacteria,1KNHZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6863492_9	1380394.JADL01000013_gene720	2.143e-153	490.0	COG2376@1|root,COG2376@2|Bacteria,1MVSR@1224|Proteobacteria,2TTK3@28211|Alphaproteobacteria,2JRKQ@204441|Rhodospirillales	204441|Rhodospirillales	G	Dak1 domain	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1,Dak2
HFD2_k127_6863492_18	1245469.S58_43170	4.021e-48	192.0	COG1461@1|root,COG1461@2|Bacteria,1MXIB@1224|Proteobacteria,2U5YZ@28211|Alphaproteobacteria,3JVDA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Dak2	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
HFD2_k127_6863492_10	1380394.JADL01000013_gene726	4.045e-133	439.0	COG3842@1|root,COG3842@2|Bacteria,1QYZ3@1224|Proteobacteria,2TT89@28211|Alphaproteobacteria,2JQ49@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
HFD2_k127_6863492_8	114615.BRADO4616	5.702e-156	500.0	COG3842@1|root,COG3842@2|Bacteria,1MVS0@1224|Proteobacteria,2TRG2@28211|Alphaproteobacteria,3JS8C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_6863492_21	114615.BRADO4617	2.496e-14	85.0	2EEPX@1|root,338HM@2|Bacteria,1NFDJ@1224|Proteobacteria,2UINA@28211|Alphaproteobacteria,3K67F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6863492_7	1380394.JADL01000013_gene729	1.41e-162	516.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TU85@28211|Alphaproteobacteria,2JZFS@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD2_k127_6863492_4	1380394.JADL01000013_gene730	1.031e-174	551.0	COG1175@1|root,COG1175@2|Bacteria,1NAZ3@1224|Proteobacteria,2U2JJ@28211|Alphaproteobacteria,2JRGQ@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD2_k127_6863492_2	114615.BRADO4620	6.149e-239	763.0	COG1653@1|root,COG1653@2|Bacteria,1N8AS@1224|Proteobacteria,2U19M@28211|Alphaproteobacteria,3JTTK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_6863492_15	296591.Bpro_0698	5.242e-115	380.0	COG1879@1|root,COG1879@2|Bacteria,1NZGQ@1224|Proteobacteria,2VJKK@28216|Betaproteobacteria,4ABXS@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein LacI	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
HFD2_k127_6863492_3	864051.BurJ1DRAFT_1800	6.931e-234	731.0	COG0671@1|root,COG0671@2|Bacteria,1MWK1@1224|Proteobacteria	1224|Proteobacteria	I	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,PAP2
HFD2_k127_6863492_1	864051.BurJ1DRAFT_1801	2.161e-280	884.0	COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria,2VXUA@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HFD2_k127_6863492_16	1242864.D187_001890	1.461e-105	353.0	COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,42R26@68525|delta/epsilon subdivisions,2WN48@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
HFD2_k127_6863492_19	1242864.D187_001891	8.379e-36	137.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,430ZH@68525|delta/epsilon subdivisions,2X9DE@28221|Deltaproteobacteria,2YUXW@29|Myxococcales	1224|Proteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
HFD2_k127_6900609_1	395495.Lcho_1774	3.523e-82	286.0	2B2UT@1|root,31VFB@2|Bacteria,1RKIH@1224|Proteobacteria,2VTT5@28216|Betaproteobacteria,1KM7U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6900609_2	29581.BW37_00727	1.098e-66	234.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,2VQEV@28216|Betaproteobacteria,474XX@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Domain of unknown function (DUF1956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
HFD2_k127_6900609_0	983917.RGE_29750	7.545e-143	476.0	COG1538@1|root,COG1538@2|Bacteria,1P0S2@1224|Proteobacteria,2VH06@28216|Betaproteobacteria,1KNCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Outer membrane efflux protein	tolC2	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_6911331_4	1205753.A989_16188	5.994e-121	420.0	COG3408@1|root,COG3408@2|Bacteria,1QU1Q@1224|Proteobacteria,1RRX2@1236|Gammaproteobacteria,1X4YN@135614|Xanthomonadales	135614|Xanthomonadales	G	coagulation factor 5 8 type	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,F5_F8_type_C,GDE_C
HFD2_k127_6911331_5	1163409.UUA_16078	1.759e-106	369.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1S4G6@1236|Gammaproteobacteria,1X3NS@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HFD2_k127_6911331_2	1300345.LF41_890	7.773e-136	441.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1S6CY@1236|Gammaproteobacteria,1X3CM@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type sugar transport systems, permease components	lacF	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HFD2_k127_6911331_3	935863.AWZR01000003_gene2774	5.352e-135	443.0	COG1653@1|root,COG1653@2|Bacteria,1MX59@1224|Proteobacteria,1RZSI@1236|Gammaproteobacteria,1X356@135614|Xanthomonadales	135614|Xanthomonadales	G	ABC transporter substrate-binding protein	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_6911331_1	215803.DB30_8576	2.943e-182	584.0	COG5368@1|root,COG5368@2|Bacteria,1NX2K@1224|Proteobacteria	1224|Proteobacteria	N	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
HFD2_k127_6911331_0	935863.AWZR01000003_gene2776	1.09e-284	906.0	COG1629@1|root,COG4771@2|Bacteria,1PSM0@1224|Proteobacteria,1T0NW@1236|Gammaproteobacteria,1X3X1@135614|Xanthomonadales	135614|Xanthomonadales	P	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HFD2_k127_6911331_6	1121022.ABENE_14920	4.388e-21	92.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,2TSRN@28211|Alphaproteobacteria,2KI1U@204458|Caulobacterales	204458|Caulobacterales	G	Beta-glucosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HFD2_k127_6913501_8	1005048.CFU_2015	2.22e-37	141.0	COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,472QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HFD2_k127_6913501_4	864051.BurJ1DRAFT_3666	1.548e-125	408.0	COG2823@1|root,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,2VK5B@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
HFD2_k127_6913501_0	864051.BurJ1DRAFT_3667	1.294e-294	908.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KNDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD2_k127_6913501_7	864051.BurJ1DRAFT_3668	2.734e-67	235.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,1KNWV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HFD2_k127_6913501_1	864051.BurJ1DRAFT_3669	1.253e-184	583.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,1KN7P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_6913501_3	296591.Bpro_2790	7.333e-149	476.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,4ACPS@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6913501_9	375286.mma_0407	1.971e-19	93.0	2EN08@1|root,33FNF@2|Bacteria,1NN71@1224|Proteobacteria,2VXVQ@28216|Betaproteobacteria,474V6@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6913501_5	864051.BurJ1DRAFT_3658	2.879e-107	359.0	COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria,2VQEI@28216|Betaproteobacteria,1KN9D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HFD2_k127_6913501_2	204773.HEAR0346	1.229e-167	533.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4734F@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD2_k127_6913501_6	420662.Mpe_A0867	4.284e-83	280.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,1KKNB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18903	-	M00698	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17.3.3	-	-	OEP
HFD2_k127_6923803_4	420662.Mpe_A0501	6.753e-60	212.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VQ4C@28216|Betaproteobacteria,1KK77@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	slmA	-	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
HFD2_k127_6923803_3	1286631.X805_15470	4.896e-85	287.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2VNRS@28216|Betaproteobacteria,1KKKT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	ssm	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HFD2_k127_6923803_2	614083.AWQR01000033_gene2882	1.644e-130	425.0	COG0697@1|root,COG0697@2|Bacteria,1N64S@1224|Proteobacteria,2VV0M@28216|Betaproteobacteria,4AF53@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
HFD2_k127_6923803_1	1265502.KB905938_gene2482	8.042e-171	540.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,4AC27@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD2_k127_6923803_0	358220.C380_03070	2.228e-236	733.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria,4AB29@80864|Comamonadaceae	28216|Betaproteobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HFD2_k127_6956870_3	987059.RBXJA2T_01715	2.629e-48	177.0	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2VMJE@28216|Betaproteobacteria,1KKQM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_6956870_0	279714.FuraDRAFT_1503	2.158e-80	279.0	COG0583@1|root,COG0583@2|Bacteria,1MVD8@1224|Proteobacteria,2VP85@28216|Betaproteobacteria	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6956870_1	580332.Slit_1984	5.268e-76	270.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,2VNIB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD2_k127_6956870_2	864051.BurJ1DRAFT_3127	5.642e-64	236.0	COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VK5Y@28216|Betaproteobacteria,1KJ8U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
HFD2_k127_6982735_1	1276756.AUEX01000009_gene1825	5.199e-123	396.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VH77@28216|Betaproteobacteria,4AAT7@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	-	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD2_k127_6982735_3	1123504.JQKD01000041_gene2868	1.692e-112	372.0	COG0583@1|root,COG0583@2|Bacteria,1PJYV@1224|Proteobacteria,2VKXY@28216|Betaproteobacteria,4ADAP@80864|Comamonadaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_6982735_4	1265502.KB905944_gene698	6.524e-88	296.0	COG2910@1|root,COG2910@2|Bacteria,1MV9B@1224|Proteobacteria,2VQXF@28216|Betaproteobacteria,4ADJW@80864|Comamonadaceae	28216|Betaproteobacteria	S	NAD-dependent epimerase dehydratase	-	-	-	ko:K07118	-	-	-	-	ko00000	-	-	-	NAD_binding_10
HFD2_k127_6982735_8	983917.RGE_36550	2.988e-13	75.0	2EIWR@1|root,335ZV@2|Bacteria,1NBRA@1224|Proteobacteria,2VW72@28216|Betaproteobacteria,1KMRF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_6982735_7	1538295.JY96_01920	5.31e-32	128.0	COG5649@1|root,COG5649@2|Bacteria,1N9MN@1224|Proteobacteria,2VX32@28216|Betaproteobacteria,1KMMK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD2_k127_6982735_0	864051.BurJ1DRAFT_1337	2.332e-141	453.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,1KJJ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD2_k127_6982735_2	983917.RGE_36560	2.095e-121	390.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,1KKA3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HFD2_k127_6982735_5	1265502.KB905961_gene337	2.575e-63	243.0	COG4539@1|root,COG4539@2|Bacteria,1RHUB@1224|Proteobacteria,2VTDF@28216|Betaproteobacteria,4AJFJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HFD2_k127_6982735_6	983917.RGE_36590	2.831e-55	196.0	COG0778@1|root,COG0778@2|Bacteria,1PSBB@1224|Proteobacteria,2VSYM@28216|Betaproteobacteria,1KPBD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD2_k127_7030843_0	314278.NB231_00330	3.521e-130	443.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HFD2_k127_7030843_1	296591.Bpro_0928	2.292e-107	357.0	COG2404@1|root,COG2404@2|Bacteria,1QWB5@1224|Proteobacteria,2VK0T@28216|Betaproteobacteria,4ACE9@80864|Comamonadaceae	28216|Betaproteobacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7030843_2	1336243.JAEA01000007_gene663	3.549e-60	230.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,1JTD3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
HFD2_k127_7042936_5	983917.RGE_02020	3.304e-43	172.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria,1KJ2J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	FIST_C	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HFD2_k127_7042936_0	864051.BurJ1DRAFT_4539	6.082e-82	282.0	2EDY7@1|root,30V4M@2|Bacteria,1RGIS@1224|Proteobacteria,2VQT2@28216|Betaproteobacteria,1KKZ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7042936_4	983917.RGE_12730	3.636e-53	201.0	COG0457@1|root,COG0457@2|Bacteria,1P0WK@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_8
HFD2_k127_7042936_1	580332.Slit_1241	6.393e-78	273.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2VQAJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM GumN family protein	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HFD2_k127_7042936_2	1265502.KB905930_gene1500	6.653e-77	263.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2VR9W@28216|Betaproteobacteria,4AE4J@80864|Comamonadaceae	28216|Betaproteobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_7042936_3	420662.Mpe_A3633	3.912e-69	235.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,1KK2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Fumarylacetoacetate (Faa) hydrolase	mhpD2	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_7063106_1	864051.BurJ1DRAFT_0193	2.788e-83	284.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,1KJZV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD2_k127_7063106_2	864051.BurJ1DRAFT_0194	3.093e-68	237.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,1KM5E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HFD2_k127_7063106_0	983917.RGE_34540	5.051e-148	501.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KMS8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
HFD2_k127_7063106_3	536019.Mesop_1222	2.795e-42	157.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD2_k127_7072436_5	1211114.ALIP01000084_gene1680	1.306e-25	105.0	COG2942@1|root,COG2942@2|Bacteria,1MX1J@1224|Proteobacteria,1RSCF@1236|Gammaproteobacteria,1X4TE@135614|Xanthomonadales	135614|Xanthomonadales	G	N-acylglucosamine 2-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim
HFD2_k127_7072436_0	420662.Mpe_A1428	1.012e-197	627.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,2VJRT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_7072436_1	420662.Mpe_A1427	3.852e-161	544.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,2VNXI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HFD2_k127_7072436_4	420662.Mpe_A1209	3.362e-52	188.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,1KM3E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HFD2_k127_7072436_2	395495.Lcho_1550	1.874e-82	279.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1KKN4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Periplasmic protein thiol	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HFD2_k127_7072436_3	395495.Lcho_1549	2.468e-73	250.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1KIYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD2_k127_7079468_2	296591.Bpro_1119	4.677e-163	527.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,4A9R9@80864|Comamonadaceae	28216|Betaproteobacteria	T	Signal transduction histidine kinase	yfhK	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_7079468_3	395495.Lcho_3377	1.797e-24	113.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2VWKS@28216|Betaproteobacteria,1KMK0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_7079468_1	983917.RGE_11790	5.272e-227	719.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,1KJZ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
HFD2_k127_7079468_0	395495.Lcho_3379	5.066e-231	730.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2W0T5@28216|Betaproteobacteria,1KN9S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KQ	GAF domain	-	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,Sigma54_activat
HFD2_k127_7080012_0	395495.Lcho_1675	2.927e-230	716.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,1KIWD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD2_k127_7080012_5	1429851.X548_20515	1.807e-08	57.0	COG5510@1|root,COG5510@2|Bacteria,1QE7S@1224|Proteobacteria,1TAQG@1236|Gammaproteobacteria,1X8WV@135614|Xanthomonadales	135614|Xanthomonadales	S	Entericidin	-	-	-	-	-	-	-	-	-	-	-	-	Entericidin
HFD2_k127_7080012_4	420662.Mpe_A2163	6.526e-124	400.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,1KK7A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD2_k127_7080012_2	1265502.KB905929_gene2268	1.296e-198	623.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,4AAYY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD2_k127_7080012_1	1458275.AZ34_06865	2.642e-223	696.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,4AAJE@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD2_k127_7080012_3	420662.Mpe_A2160	4.327e-125	417.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,1KJ0A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
HFD2_k127_7083838_0	1336243.JAEA01000001_gene1992	1.547e-189	616.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,1JU0Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	dppA	-	-	ko:K12368	ko02010,ko02030,map02010,map02030	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_7083838_3	864051.BurJ1DRAFT_0694	1.537e-156	499.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria,1KM3D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD2_k127_7083838_1	864051.BurJ1DRAFT_0696	3.629e-181	593.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,1KK7N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	hop	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HFD2_k127_7083838_2	426117.M446_1694	9.645e-158	508.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,1JTX6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	dppF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	-	ko:K12372	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_7083838_4	1504672.669787118	6.187e-155	510.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4AA2A@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K12371	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_7083838_5	595537.Varpa_0422	9.292e-145	464.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VHX8@28216|Betaproteobacteria,4AD2R@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppC	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_7083838_6	1504672.669787120	6.629e-123	396.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHND@28216|Betaproteobacteria,4ADJK@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD2_k127_7093316_0	1408164.MOLA814_00505	1.637e-289	900.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1KQ8E@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7093316_6	864051.BurJ1DRAFT_0172	3.932e-12	70.0	2CIC8@1|root,33JK4@2|Bacteria,1NH5Z@1224|Proteobacteria,2VYDU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7093316_1	365044.Pnap_0392	2.289e-273	852.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,4ABKM@80864|Comamonadaceae	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD2_k127_7093316_3	1390370.O203_13345	1.961e-82	291.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1S32F@1236|Gammaproteobacteria,1YE6Z@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HFD2_k127_7093316_5	330214.NIDE1073	2.302e-52	186.0	COG3813@1|root,COG3813@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	MA20_39405	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
HFD2_k127_7093316_4	983917.RGE_29310	5.69e-63	224.0	2E8G8@1|root,332UI@2|Bacteria,1N7XZ@1224|Proteobacteria,2W3AB@28216|Betaproteobacteria,1KNT8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HFD2_k127_7093316_2	93220.LV28_13020	1.052e-108	356.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1K23R@119060|Burkholderiaceae	28216|Betaproteobacteria	H	2-dehydropantoate 2-reductase	panE2	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD2_k127_7109115_6	644801.Psest_2218	1.373e-102	337.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1Z12Q@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD2_k127_7109115_4	338969.Rfer_0385	4.809e-138	460.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2VN6N@28216|Betaproteobacteria,4AEZ2@80864|Comamonadaceae	28216|Betaproteobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD2_k127_7109115_11	1366050.N234_08605	1.151e-23	104.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2VWCN@28216|Betaproteobacteria,1KA3Y@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD2_k127_7109115_2	977880.RALTA_A1126	1.887e-205	665.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2VIW2@28216|Betaproteobacteria,1K4B8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	fad dependent oxidoreductase	ethA	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,NAD_binding_8,Pyr_redox_2,Thi4
HFD2_k127_7109115_10	983917.RGE_23560	5.628e-64	250.0	COG1877@1|root,COG1877@2|Bacteria,1PFWC@1224|Proteobacteria,2VXSM@28216|Betaproteobacteria,1KMU2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HFD2_k127_7109115_1	1538295.JY96_08420	0.0	1143.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2VIAZ@28216|Betaproteobacteria,1KPJ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HFD2_k127_7109115_3	420662.Mpe_A1216	2.926e-142	460.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,1KM0J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HFD2_k127_7109115_0	420662.Mpe_A1217	0.0	1415.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,2W0AD@28216|Betaproteobacteria,1KMY4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7109115_8	420662.Mpe_A1218	6.067e-71	274.0	2ESGA@1|root,33K10@2|Bacteria,1NNJA@1224|Proteobacteria,2W3CW@28216|Betaproteobacteria,1KNRV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7109115_5	420662.Mpe_A1219	2.083e-114	387.0	COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,2W17I@28216|Betaproteobacteria,1KN07@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
HFD2_k127_7109115_7	420662.Mpe_A1220	2.452e-87	293.0	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,2W2BF@28216|Betaproteobacteria,1KNIB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7109115_9	420662.Mpe_A1221	1.216e-67	233.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2WF1B@28216|Betaproteobacteria,1KPKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7109115_12	396588.Tgr7_0546	1.553e-15	83.0	2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,1X1RV@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
HFD2_k127_7110847_2	641524.ADICYQ_4182	1.885e-80	289.0	2DVXG@1|root,33XK4@2|Bacteria	2|Bacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7110847_3	748280.NH8B_3146	1.219e-58	207.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,2KT2V@206351|Neisseriales	206351|Neisseriales	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HFD2_k127_7110847_1	261292.Nit79A3_3260	1.411e-95	352.0	COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,2VJ0W@28216|Betaproteobacteria,372GC@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HFD2_k127_7110847_0	1123368.AUIS01000016_gene2551	9.558e-188	620.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2NCBG@225057|Acidithiobacillales	1236|Gammaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HFD2_k127_7110847_4	1485544.JQKP01000001_gene952	4.761e-27	121.0	2BGQG@1|root,32APG@2|Bacteria,1PXFZ@1224|Proteobacteria,2WCW7@28216|Betaproteobacteria,44WJ8@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7114_4	987059.RBXJA2T_12487	4.951e-99	324.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1KK2Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HFD2_k127_7114_3	864051.BurJ1DRAFT_3687	2.44e-100	332.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,1KJPI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	molybdenum cofactor	mogA	-	2.7.7.75	ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HFD2_k127_7114_5	1265502.KB905931_gene1676	7.446e-54	196.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,4ADKX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the UPF0307 family	yjgA	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
HFD2_k127_7114_0	1265502.KB905931_gene1677	3.984e-232	725.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,4ABC3@80864|Comamonadaceae	28216|Betaproteobacteria	S	peptidase U62, modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD2_k127_7114_1	864051.BurJ1DRAFT_3684	2.802e-205	642.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,1KIWC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_7114_2	395495.Lcho_1780	1.904e-147	474.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VHHD@28216|Betaproteobacteria,1KJ5Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP dicarboxylate transporter, DctM subunit	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	DctM
HFD2_k127_7116292_5	983917.RGE_07580	4.64e-35	136.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,1KKPH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD2_k127_7116292_4	1265502.KB905945_gene612	4.602e-80	273.0	COG0454@1|root,COG0456@2|Bacteria,1QUZC@1224|Proteobacteria,2WGMV@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_3
HFD2_k127_7116292_3	864051.BurJ1DRAFT_1063	1.571e-86	294.0	2C9ES@1|root,32HUV@2|Bacteria,1RKUI@1224|Proteobacteria,2VSTQ@28216|Betaproteobacteria,1KM4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2726)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2726
HFD2_k127_7116292_2	864051.BurJ1DRAFT_1062	1.867e-129	422.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,1KK3E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HFD2_k127_7116292_0	987059.RBXJA2T_14451	0.0	1048.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,1KJN9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HFD2_k127_7116292_1	983917.RGE_02680	1.596e-211	664.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_48,DUF3372,PUD
HFD2_k127_7135738_7	1095769.CAHF01000013_gene3387	1.429e-43	161.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,2VIDQ@28216|Betaproteobacteria,473XX@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	coxM	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
HFD2_k127_7135738_6	204773.HEAR1486	7.854e-51	193.0	2B3U0@1|root,31WHT@2|Bacteria,1RIS2@1224|Proteobacteria,2VSJF@28216|Betaproteobacteria,474B6@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7135738_5	395495.Lcho_4312	8.551e-78	263.0	29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,2VT0U@28216|Betaproteobacteria,1KM7K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HFD2_k127_7135738_4	1265502.KB905958_gene239	5.073e-106	357.0	COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,2VIH3@28216|Betaproteobacteria,4A9PF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HFD2_k127_7135738_0	864051.BurJ1DRAFT_0185	0.0	1049.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,1KJRB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_7135738_8	1265502.KB905958_gene237	6.038e-43	177.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
HFD2_k127_7135738_3	983917.RGE_02710	1.326e-118	400.0	COG3279@1|root,COG3279@2|Bacteria,1R9Q4@1224|Proteobacteria,2WEES@28216|Betaproteobacteria,1KN7W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD2_k127_7135738_1	987059.RBXJA2T_01165	3.172e-156	508.0	COG2972@1|root,COG2972@2|Bacteria,1R5R0@1224|Proteobacteria,2VM7Q@28216|Betaproteobacteria,1KN1G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HFD2_k127_7135738_2	864051.BurJ1DRAFT_1528	3.611e-134	432.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,1KKH9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_7148501_13	296591.Bpro_2035	5.109e-103	340.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,4AAYK@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD2_k127_7148501_0	358220.C380_02070	0.0	1659.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAP6@80864|Comamonadaceae	28216|Betaproteobacteria	V	Transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD2_k127_7148501_7	987059.RBXJA2T_02377	1.15e-154	537.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KK2E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HFD2_k127_7148501_11	987059.RBXJA2T_04773	8.329e-110	372.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2VKXI@28216|Betaproteobacteria,1KM7G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD2_k127_7148501_12	1121015.N789_13075	5.752e-106	351.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,1RRJP@1236|Gammaproteobacteria,1X60E@135614|Xanthomonadales	135614|Xanthomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HFD2_k127_7148501_2	864051.BurJ1DRAFT_4671	2.165e-254	797.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2VIT5@28216|Betaproteobacteria,1KKBA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_7148501_1	395495.Lcho_3847	3.233e-281	872.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria,1KIZA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	fad dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,Pyr_redox_2
HFD2_k127_7148501_9	1265502.KB905962_gene360	2.406e-127	416.0	COG0583@1|root,COG0583@2|Bacteria,1R74J@1224|Proteobacteria,2VNHS@28216|Betaproteobacteria,4AAX6@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_7148501_3	420662.Mpe_A3556	5.736e-252	782.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1KIWT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HFD2_k127_7148501_14	1144307.PMI04_01731	1.375e-89	303.0	COG0639@1|root,COG0639@2|Bacteria,1N4BG@1224|Proteobacteria,2TR4D@28211|Alphaproteobacteria,2K4R8@204457|Sphingomonadales	204457|Sphingomonadales	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD2_k127_7148501_23	886293.Sinac_1598	5.568e-10	69.0	2FDPG@1|root,345QM@2|Bacteria,2J3XF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7148501_20	1265502.KB905955_gene459	6.574e-39	149.0	2ASHY@1|root,31HYC@2|Bacteria,1RIM4@1224|Proteobacteria,2VSD6@28216|Betaproteobacteria,4AEK4@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7148501_4	1265502.KB905955_gene458	5.564e-186	585.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,4A9UB@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD2_k127_7148501_22	395495.Lcho_1302	5.224e-30	119.0	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,1KMKD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HFD2_k127_7148501_8	1286631.X805_40790	1.684e-136	443.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1KKPX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	rfaF	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD2_k127_7148501_10	983917.RGE_01620	7.244e-114	389.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_7,PAS_8,PilJ,Response_reg
HFD2_k127_7148501_21	1479235.KK366039_gene1507	2.315e-31	127.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XNJI@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9,Response_reg
HFD2_k127_7148501_19	1265502.KB905955_gene454	6.22e-49	180.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2VJ7E@28216|Betaproteobacteria,4ADA6@80864|Comamonadaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_7148501_24	420662.Mpe_A3548	1.228e-09	69.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2VSFF@28216|Betaproteobacteria,1KM8C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HFD2_k127_7148501_17	420662.Mpe_A3547	9.103e-76	259.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,1KMJJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HFD2_k127_7148501_5	395495.Lcho_1303	2.975e-166	526.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,1KJBU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_6,Formyl_trans_N
HFD2_k127_7148501_18	296591.Bpro_0333	1.082e-50	183.0	COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,4AE1B@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD2_k127_7148501_6	1265502.KB905955_gene450	3.786e-156	497.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,4AAFQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	hydrolase of the alpha	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HFD2_k127_7148501_16	1265502.KB905955_gene449	5.5e-80	271.0	2CDFS@1|root,32RXQ@2|Bacteria,1N09V@1224|Proteobacteria,2VR7P@28216|Betaproteobacteria,4AE2J@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2946)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2944
HFD2_k127_7148501_15	358220.C380_02060	2.194e-89	304.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,4ADS8@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_7148501_25	1229205.BUPH_03798	0.0006291	42.0	COG0582@1|root,COG0582@2|Bacteria,1QY45@1224|Proteobacteria,2WHB8@28216|Betaproteobacteria,1K75C@119060|Burkholderiaceae	28216|Betaproteobacteria	L	viral genome integration into host DNA	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD2_k127_7171161_1	365044.Pnap_1316	1.319e-77	265.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria,4AE0D@80864|Comamonadaceae	28216|Betaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HFD2_k127_7171161_0	983917.RGE_37700	0.0	1899.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria	28216|Betaproteobacteria	G	carbohydrate binding	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HFD2_k127_71776_1	864051.BurJ1DRAFT_0681	1.967e-174	552.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KJI0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HFD2_k127_71776_2	395495.Lcho_1441	2.539e-117	385.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,1KKVY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Uroporphyrin-III C-methyltransferase	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HFD2_k127_71776_3	1265502.KB905943_gene2771	4.373e-115	390.0	COG2199@1|root,COG3706@2|Bacteria,1R9NB@1224|Proteobacteria,2VSWC@28216|Betaproteobacteria,4AJP6@80864|Comamonadaceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP
HFD2_k127_71776_4	243231.GSU2316	1.08e-56	224.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HFD2_k127_71776_0	365046.Rta_19460	4.134e-216	680.0	COG0745@1|root,COG0784@1|root,COG0840@1|root,COG2199@1|root,COG2203@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG2203@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,4A9XJ@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
HFD2_k127_7181877_4	596153.Alide_3614	1.157e-83	282.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HFD2_k127_7181877_11	864051.BurJ1DRAFT_0130	0.0002749	50.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VIUD@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD2_k127_7181877_1	1223521.BBJX01000002_gene2866	1.293e-265	842.0	COG0543@1|root,COG1018@1|root,COG1290@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,COG1290@2|Bacteria,1MV72@1224|Proteobacteria,2VI6M@28216|Betaproteobacteria,4AGTD@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_7181877_5	987059.RBXJA2T_18939	3.199e-64	239.0	COG3203@1|root,COG3203@2|Bacteria,1R5T2@1224|Proteobacteria,2VMH6@28216|Betaproteobacteria,1KPGF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD2_k127_7181877_8	59538.XP_005965322.1	9.465e-34	135.0	COG3474@1|root,KOG3453@2759|Eukaryota	2759|Eukaryota	C	electron transfer activity	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD2_k127_7181877_2	1005048.CFU_1840	2.681e-133	432.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,475EI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD2_k127_7181877_9	1144319.PMI16_00807	1.69e-21	108.0	COG1622@1|root,COG1622@2|Bacteria,1NEC9@1224|Proteobacteria,2VWA0@28216|Betaproteobacteria,477JR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cupredoxin-like domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HFD2_k127_7181877_7	543728.Vapar_4005	1.698e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,1PT8E@1224|Proteobacteria,2W1XX@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_7181877_6	543728.Vapar_4006	2.667e-49	196.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2VSSM@28216|Betaproteobacteria	28216|Betaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD2_k127_7181877_3	395495.Lcho_1454	3.074e-90	306.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,1KKH6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_7181877_0	983917.RGE_06660	1.69e-281	868.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KJHT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HFD2_k127_7189299_6	420662.Mpe_A3197	4.64e-56	196.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7189299_0	864051.BurJ1DRAFT_4242	4.468e-226	708.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1KJX3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_7189299_2	983917.RGE_42130	1.716e-148	476.0	COG0351@1|root,COG0351@2|Bacteria,1QUEP@1224|Proteobacteria,2WEGK@28216|Betaproteobacteria,1KKCE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HFD2_k127_7189299_7	864051.BurJ1DRAFT_4240	4.405e-34	130.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KMIY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HFD2_k127_7189299_4	365044.Pnap_3354	1.51e-65	225.0	COG2199@1|root,COG3706@2|Bacteria,1QYJ0@1224|Proteobacteria,2WHFH@28216|Betaproteobacteria,4AJW3@80864|Comamonadaceae	28216|Betaproteobacteria	T	Response regulator receiver domain	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HFD2_k127_7189299_3	1265502.KB905941_gene2908	7.741e-66	225.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,4AE26@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator, receiver	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HFD2_k127_7189299_5	1265502.KB905941_gene2907	1.891e-61	218.0	COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,4ADYW@80864|Comamonadaceae	28216|Betaproteobacteria	NT	PFAM CheW domain protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HFD2_k127_7189299_1	1265502.KB905941_gene2906	8.275e-203	648.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,4ABIH@80864|Comamonadaceae	28216|Betaproteobacteria	NT	PFAM chemotaxis sensory transducer	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
HFD2_k127_7191325_2	365046.Rta_32660	1.566e-125	406.0	COG0624@1|root,COG3195@1|root,COG0624@2|Bacteria,COG3195@2|Bacteria,1MVUX@1224|Proteobacteria,2VIGB@28216|Betaproteobacteria,4AB68@80864|Comamonadaceae	28216|Betaproteobacteria	E	Amidase, hydantoinase carbamoylase family	uraD	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,OHCU_decarbox,Peptidase_M20,Peptidase_M28
HFD2_k127_7191325_0	365046.Rta_32670	1.57e-210	674.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VK9D@28216|Betaproteobacteria,4A9VN@80864|Comamonadaceae	28216|Betaproteobacteria	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD2_k127_7191325_1	1500894.JQNN01000001_gene4352	4.27e-181	591.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2VK1F@28216|Betaproteobacteria,4742X@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HFD2_k127_7191325_3	1286631.X805_10580	1.759e-54	197.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2VIMG@28216|Betaproteobacteria,1KJXF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD2_k127_7197725_13	1538295.JY96_10625	8.817e-47	173.0	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2VMB4@28216|Betaproteobacteria,1KK8Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	TIGRFAM type IV VI secretion system protein, DotU family	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
HFD2_k127_7197725_0	543728.Vapar_0516	0.0	1077.0	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2VJ0M@28216|Betaproteobacteria,4AAAS@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM type VI secretion protein IcmF	icmF	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
HFD2_k127_7197725_14	62928.azo3889	1.462e-40	161.0	COG3913@1|root,COG3913@2|Bacteria,1N01G@1224|Proteobacteria,2VUP0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM type VI secretion-associated protein, BMA_A0400 family	-	-	-	ko:K11890	ko02025,map02025	-	-	-	ko00000,ko00001,ko02044	-	-	-	DUF2094
HFD2_k127_7197725_5	1218084.BBJK01000017_gene1840	2.228e-159	523.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KFC2@119060|Burkholderiaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4384,Pkinase
HFD2_k127_7197725_7	530564.Psta_1804	1.325e-145	485.0	COG3516@1|root,COG3517@1|root,COG3516@2|Bacteria,COG3517@2|Bacteria,2J2YH@203682|Planctomycetes	203682|Planctomycetes	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	-	-	-	-	-	-	-	-	-	T6SS_VipA,VipB
HFD2_k127_7197725_16	75379.Tint_0377	2.46e-17	93.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2VXRV@28216|Betaproteobacteria,1KMRT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HFD2_k127_7197725_9	983917.RGE_42650	3.926e-128	413.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,1KIT2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
HFD2_k127_7197725_11	987059.RBXJA2T_11573	6.335e-68	236.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,1KKZP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HFD2_k127_7197725_8	420662.Mpe_A0507	1.217e-139	447.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,1KIZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD2_k127_7197725_2	420662.Mpe_A0508	2.149e-209	656.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,1KJSN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD2_k127_7197725_1	987059.RBXJA2T_11588	8.748e-313	965.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KJB3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_7197725_17	224911.27350827	1.434e-05	48.0	2F0SV@1|root,33TUX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7197725_6	1265502.KB905938_gene2494	5.031e-147	475.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,4A9VJ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD2_k127_7197725_12	1538295.JY96_15195	1.235e-51	187.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,1KM31@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HFD2_k127_7197725_15	1538295.JY96_15200	9.54e-40	149.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,1KMAC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HFD2_k127_7197725_18	204669.Acid345_1029	0.0001351	46.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria,2JJER@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
HFD2_k127_7197725_3	1265502.KB905938_gene2497	9.556e-196	614.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,4AA8G@80864|Comamonadaceae	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HFD2_k127_7197725_4	864051.BurJ1DRAFT_4378	6.443e-191	612.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,1KK4B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HFD2_k127_7197725_10	420662.Mpe_A0516	2.45e-109	356.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,1KJR3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HFD2_k127_7204594_2	1265502.KB905946_gene1157	5.544e-168	555.0	COG4799@1|root,COG4799@2|Bacteria,1NSRV@1224|Proteobacteria,2WI01@28216|Betaproteobacteria,4AK46@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,Carboxyl_trans
HFD2_k127_7204594_6	1192868.CAIU01000013_gene1840	1.691e-113	375.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,43HPH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_7204594_7	887898.HMPREF0551_2224	1.041e-92	313.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VIII@28216|Betaproteobacteria,1K5V6@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_7204594_9	983917.RGE_01880	9.988e-66	243.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,2WA5F@28216|Betaproteobacteria,1KP8K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_7204594_3	1100721.ALKO01000016_gene1432	5.028e-147	481.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VMNH@28216|Betaproteobacteria,4ABTU@80864|Comamonadaceae	28216|Betaproteobacteria	BQ	Histone deacetylase superfamily	aphA1	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD2_k127_7204594_8	395495.Lcho_3630	1.574e-66	250.0	COG1597@1|root,COG1597@2|Bacteria,1PRCT@1224|Proteobacteria,2W9VB@28216|Betaproteobacteria,1KNXF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD2_k127_7204594_1	1157708.KB907450_gene5295	1.612e-207	651.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,4A9ZE@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD dependent oxidoreductase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
HFD2_k127_7204594_0	62928.azo0116	3.191e-279	865.0	COG0775@1|root,COG0775@2|Bacteria,1MUMQ@1224|Proteobacteria,2VKRE@28216|Betaproteobacteria,2KXRE@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations	amn	-	3.2.2.4	ko:K01241	ko00230,map00230	-	R00182	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	AMNp_N,PNP_UDP_1
HFD2_k127_7204594_4	1276756.AUEX01000026_gene250	8.911e-143	468.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria,4AAFT@80864|Comamonadaceae	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD2_k127_7204594_5	365044.Pnap_3548	1.553e-128	441.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,4AB0C@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HFD2_k127_7241896_3	596153.Alide_3135	2.75e-22	98.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,4AC48@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD2_k127_7241896_1	420662.Mpe_A2937	2.269e-104	349.0	COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,1KJ11@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD2_k127_7241896_0	1265502.KB905943_gene2746	3.234e-241	748.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,4AABM@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD2_k127_7241896_2	864051.BurJ1DRAFT_1572	8.257e-73	248.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,1KKSD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD2_k127_7241896_4	420662.Mpe_A2940	7.855e-07	53.0	COG4970@1|root,COG4970@2|Bacteria,1N43I@1224|Proteobacteria,2VUQM@28216|Betaproteobacteria,1KMEB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
HFD2_k127_7256298_2	215803.DB30_8572	2.58e-185	621.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HFD2_k127_7256298_0	983917.RGE_15990	4.471e-267	859.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2VMAU@28216|Betaproteobacteria,1KMHE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD2_k127_7256298_5	1278073.MYSTI_07412	2.706e-102	349.0	COG4340@1|root,COG4340@2|Bacteria,1R9YQ@1224|Proteobacteria,43853@68525|delta/epsilon subdivisions,2X3F2@28221|Deltaproteobacteria,2YVSZ@29|Myxococcales	28221|Deltaproteobacteria	S	2OG-Fe dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-Fe_Oxy_2
HFD2_k127_7256298_9	983917.RGE_14220	1.533e-43	175.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2VTR4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HFD2_k127_7256298_11	864051.BurJ1DRAFT_1228	3.222e-28	123.0	COG3637@1|root,COG3637@2|Bacteria,1PGX7@1224|Proteobacteria,2W99A@28216|Betaproteobacteria,1KNXD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl
HFD2_k127_7256298_1	397945.Aave_2779	2.306e-189	594.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,4AASZ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
HFD2_k127_7256298_4	420662.Mpe_A2190	1.655e-148	485.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VHXM@28216|Betaproteobacteria,1KJSV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Luciferase family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD2_k127_7256298_8	1117647.M5M_15035	3.762e-58	226.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RZRN@1236|Gammaproteobacteria,1JB5Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,TPR_12,TPR_7
HFD2_k127_7256298_6	614083.AWQR01000005_gene1149	1.612e-81	277.0	COG4101@1|root,COG4101@2|Bacteria,1RB8W@1224|Proteobacteria,2VPF8@28216|Betaproteobacteria,4AD0E@80864|Comamonadaceae	28216|Betaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD2_k127_7256298_10	1265502.KB905929_gene2210	1.216e-36	138.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,4AFG6@80864|Comamonadaceae	28216|Betaproteobacteria	K	'Cold-shock' DNA-binding domain	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD2_k127_7256298_3	1265502.KB905929_gene2208	2.152e-175	560.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VJHE@28216|Betaproteobacteria,4ACC4@80864|Comamonadaceae	28216|Betaproteobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HFD2_k127_7256298_7	987059.RBXJA2T_01570	2.263e-77	277.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3852@2|Bacteria,1NRP8@1224|Proteobacteria,2VJNX@28216|Betaproteobacteria,1KJ6Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_3,PAS_7,PAS_8,PAS_9,PilJ,Response_reg
HFD2_k127_7279057_8	631362.Thi970DRAFT_00956	1.173e-07	66.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S	-	-	-	ko:K00184,ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	5.A.3	-	-	Fer4_11,Fer4_4,Fer4_7
HFD2_k127_7279057_0	864051.BurJ1DRAFT_3313	0.0	1733.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,1KKFR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD2_k127_7279057_3	864051.BurJ1DRAFT_3320	4.235e-103	349.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,1KK5B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	narX	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
HFD2_k127_7279057_5	864051.BurJ1DRAFT_3321	5.558e-95	321.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,1KM2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, luxR family	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_7279057_4	864051.BurJ1DRAFT_3322	8.427e-103	344.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,1KKVY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Uroporphyrin-III C-methyltransferase	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HFD2_k127_7279057_7	1163617.SCD_n02705	2.852e-21	99.0	COG0316@1|root,COG0316@2|Bacteria,1N8ZN@1224|Proteobacteria,2W5FR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulphur cluster biosynthesis	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD2_k127_7279057_6	187272.Mlg_0997	3.537e-47	174.0	COG2920@1|root,COG2920@2|Bacteria,1MWK9@1224|Proteobacteria,1RYE1@1236|Gammaproteobacteria,1WWZ5@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HFD2_k127_7279057_1	864051.BurJ1DRAFT_3323	2.138e-190	606.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,1KKQX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HFD2_k127_7279057_2	864051.BurJ1DRAFT_3324	9.549e-159	505.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HFD2_k127_7279416_3	194867.ALBQ01000021_gene1902	4.955e-05	49.0	COG2755@1|root,COG2755@2|Bacteria,1NQY8@1224|Proteobacteria,2UPSQ@28211|Alphaproteobacteria,2K8UK@204457|Sphingomonadales	204457|Sphingomonadales	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7279416_2	365044.Pnap_0042	8.042e-52	185.0	COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,2VSI0@28216|Betaproteobacteria,4AJC0@80864|Comamonadaceae	28216|Betaproteobacteria	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
HFD2_k127_7279416_0	883126.HMPREF9710_04469	6.71e-128	430.0	COG2755@1|root,COG2755@2|Bacteria,1RDF0@1224|Proteobacteria	1224|Proteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD2_k127_7279416_1	715226.ABI_28740	3.501e-113	370.0	COG0657@1|root,COG0657@2|Bacteria,1QDQP@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
HFD2_k127_7292684_0	983917.RGE_41580	7.626e-195	612.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,1KJZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD2_k127_7292684_1	395495.Lcho_0289	7.303e-183	597.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2VMEP@28216|Betaproteobacteria,1KITQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	bplA	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_7292684_3	983917.RGE_41560	7.2e-89	316.0	COG0110@1|root,COG0110@2|Bacteria,1MZV9@1224|Proteobacteria,2VN51@28216|Betaproteobacteria,1KKI2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	bplB	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep
HFD2_k127_7292684_2	864051.BurJ1DRAFT_4122	1.523e-139	447.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1KK9Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	wlbC	-	2.6.1.98	ko:K13017	ko00520,map00520	-	R10141	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HFD2_k127_7311144_0	1265502.KB905933_gene2029	0.0	1008.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4A9M6@80864|Comamonadaceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD2_k127_7311144_6	420662.Mpe_A1159	3.415e-105	362.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,1KKHH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CYTH	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHAD,CYTH
HFD2_k127_7311144_8	1268622.AVS7_00401	6.526e-49	177.0	COG3861@1|root,COG3861@2|Bacteria,1MZM2@1224|Proteobacteria,2WHRM@28216|Betaproteobacteria,4AF98@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HFD2_k127_7311144_2	1245471.PCA10_26390	6.817e-162	527.0	COG4977@1|root,COG4977@2|Bacteria,1QV1S@1224|Proteobacteria,1T40U@1236|Gammaproteobacteria,1YM0K@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD2_k127_7311144_9	1301098.PKB_2129	4.5e-42	165.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_7311144_5	365044.Pnap_1026	2.323e-124	429.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,4AC1Z@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methyltransferase type 11	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD2_k127_7311144_7	234267.Acid_5193	6.748e-82	282.0	COG0500@1|root,COG2226@2|Bacteria,3Y5GM@57723|Acidobacteria	57723|Acidobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD2_k127_7311144_4	1095769.CAHF01000023_gene504	3.858e-128	412.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHZJ@28216|Betaproteobacteria,475TP@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N
HFD2_k127_7311144_11	864051.BurJ1DRAFT_0274	4.355e-19	101.0	2E9SN@1|root,32ZFH@2|Bacteria,1N8MD@1224|Proteobacteria,2VW4H@28216|Betaproteobacteria,1KMQ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3460
HFD2_k127_7311144_3	983917.RGE_36790	5.595e-140	451.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,1KJBJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD2_k127_7311144_10	1519464.HY22_00860	2.46e-22	101.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_7311144_1	1265502.KB905954_gene428	5.419e-164	524.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,4ADJN@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_7324809_7	1223521.BBJX01000011_gene17	8.409e-21	93.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,2VTZ4@28216|Betaproteobacteria,4AEXE@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD2_k127_7324809_1	420662.Mpe_A1238	4.542e-193	609.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,1KKCF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HFD2_k127_7324809_2	543728.Vapar_1230	1.852e-191	606.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,4ACT4@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_7324809_6	391735.Veis_3950	2.288e-75	259.0	COG1309@1|root,COG1309@2|Bacteria,1QYD4@1224|Proteobacteria,2VMMD@28216|Betaproteobacteria,4ADMH@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	paaR	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD2_k127_7324809_0	395495.Lcho_2403	1.126e-238	757.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1KJ6S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HFD2_k127_7324809_5	1157708.KB907452_gene3752	5.508e-104	346.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2VHE9@28216|Betaproteobacteria,4ACR5@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_7324809_4	378806.STAUR_0597	9.718e-121	407.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2YU2A@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HFD2_k127_7324809_3	397945.Aave_2098	1.243e-182	573.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VP54@28216|Betaproteobacteria,4AFR3@80864|Comamonadaceae	28216|Betaproteobacteria	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HFD2_k127_7339006_9	113395.AXAI01000010_gene2086	2.09e-53	194.0	COG1075@1|root,COG1075@2|Bacteria,1NPX1@1224|Proteobacteria	1224|Proteobacteria	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_2
HFD2_k127_7339006_5	1265502.KB905938_gene2431	1.934e-139	466.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2VKCZ@28216|Betaproteobacteria,4AC2B@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_7339006_3	365046.Rta_15670	4.771e-159	526.0	COG4177@1|root,COG4177@2|Bacteria,1MZDJ@1224|Proteobacteria,2VJSE@28216|Betaproteobacteria,4AAFD@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_7339006_4	358220.C380_16385	4.55e-150	493.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2VJCG@28216|Betaproteobacteria,4AC0G@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD2_k127_7339006_7	864051.BurJ1DRAFT_4862	3.067e-114	374.0	COG0410@1|root,COG0410@2|Bacteria,1MW9R@1224|Proteobacteria,2VNG7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD2_k127_7339006_6	1265502.KB905938_gene2427	7.429e-117	381.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VI76@28216|Betaproteobacteria,4ABC1@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_7339006_0	1265502.KB905938_gene2426	6.589e-225	707.0	COG3469@1|root,COG3509@1|root,COG3469@2|Bacteria,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,4ACW5@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Fibronectin type III domain protein	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	Esterase_phd,fn3
HFD2_k127_7339006_1	358220.C380_16405	7.332e-220	688.0	COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2VJMT@28216|Betaproteobacteria,4AC97@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_7339006_8	596154.Alide2_3074	1.144e-94	338.0	COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,4AA5G@80864|Comamonadaceae	28216|Betaproteobacteria	M	lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT,Sel1
HFD2_k127_7339006_2	1265502.KB905938_gene2424	2.411e-200	632.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQ9@28216|Betaproteobacteria,4AAAF@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HFD2_k127_7348661_6	983917.RGE_40570	2.266e-58	222.0	COG0526@1|root,COG0526@2|Bacteria,1MYEY@1224|Proteobacteria,2VSNJ@28216|Betaproteobacteria,1KM0S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7348661_1	420662.Mpe_A2188	8.698e-116	394.0	COG5501@1|root,COG5501@2|Bacteria,1R6CY@1224|Proteobacteria,2VNHC@28216|Betaproteobacteria,1KJVY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
HFD2_k127_7348661_2	420662.Mpe_A2189	1.307e-105	351.0	COG0491@1|root,COG0491@2|Bacteria,1RDXA@1224|Proteobacteria,2VSBH@28216|Betaproteobacteria,1KKKX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_7348661_5	543728.Vapar_3046	1.05e-70	259.0	COG3832@1|root,COG3832@2|Bacteria,1PUKN@1224|Proteobacteria,2WBSR@28216|Betaproteobacteria,4AI9B@80864|Comamonadaceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HFD2_k127_7348661_0	543728.Vapar_3045	5.586e-127	429.0	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2VPSR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HFD2_k127_7348661_3	497321.C664_00585	1.429e-94	332.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2VNJJ@28216|Betaproteobacteria,2KW2T@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur oxidation protein SoxZ	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
HFD2_k127_7348661_7	983917.RGE_40620	1.577e-41	155.0	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2VX9I@28216|Betaproteobacteria,1KMEU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7348661_4	983917.RGE_40630	1.597e-71	247.0	2C1VZ@1|root,32R98@2|Bacteria,1RJ8X@1224|Proteobacteria,2VRVA@28216|Betaproteobacteria,1KM3C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7388614_7	543728.Vapar_4353	8.883e-107	352.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,4AAVR@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD2_k127_7388614_4	1357272.AVEO02000199_gene179	1.366e-126	436.0	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,1RWSA@1236|Gammaproteobacteria,1Z8TU@136849|Pseudomonas syringae group	1224|Proteobacteria	K	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD2_k127_7388614_12	1366050.N234_09545	4.346e-53	206.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2VZFU@28216|Betaproteobacteria,1K6PV@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_7388614_10	756067.MicvaDRAFT_3593	1.148e-58	220.0	COG3271@1|root,COG3271@2|Bacteria,1G37M@1117|Cyanobacteria,1H999@1150|Oscillatoriales	1117|Cyanobacteria	S	Phytochelatin synthase	-	-	-	-	-	-	-	-	-	-	-	-	Phytochelatin
HFD2_k127_7388614_2	983917.RGE_00230	7.38e-156	509.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VKKF@28216|Betaproteobacteria,1KJTI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD2_k127_7388614_6	296591.Bpro_2213	8.861e-120	396.0	COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2VQDT@28216|Betaproteobacteria,4AJFR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD2_k127_7388614_3	296591.Bpro_2212	4.97e-153	490.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2VHN7@28216|Betaproteobacteria,4ADVE@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.122	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	M00114	R07675,R08926	RC00066,RC00161	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
HFD2_k127_7388614_8	296591.Bpro_2210	4.579e-106	348.0	COG1802@1|root,COG1802@2|Bacteria,1RAW8@1224|Proteobacteria,2VQSV@28216|Betaproteobacteria,4ADJD@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_7388614_5	296591.Bpro_2209	2.705e-121	402.0	COG0329@1|root,COG0329@2|Bacteria,1P6EY@1224|Proteobacteria,2WGBG@28216|Betaproteobacteria,4AE8T@80864|Comamonadaceae	28216|Betaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD2_k127_7388614_1	614083.AWQR01000028_gene3166	1.785e-179	566.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2VPDF@28216|Betaproteobacteria,4ACHB@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_7388614_11	296591.Bpro_2207	3.562e-58	207.0	COG3090@1|root,COG3090@2|Bacteria,1RE57@1224|Proteobacteria,2VRYN@28216|Betaproteobacteria,4ADZ5@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_7388614_0	296591.Bpro_2206	1.343e-193	653.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4AA1X@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_7388614_9	296591.Bpro_2205	3.519e-70	263.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VR36@28216|Betaproteobacteria,4AEK9@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_7400024_0	595537.Varpa_5188	2.185e-221	694.0	COG2223@1|root,COG2223@2|Bacteria,1MVFQ@1224|Proteobacteria,2WGVG@28216|Betaproteobacteria,4AJD6@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HFD2_k127_7400024_1	1380350.JIAP01000003_gene4884	9.684e-91	305.0	COG1028@1|root,COG1028@2|Bacteria,1R6C1@1224|Proteobacteria,2U69X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7400024_2	582744.Msip34_2721	8.958e-62	224.0	COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2VTNU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
HFD2_k127_7442537_0	420662.Mpe_A2317	0.0	1062.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,1KK4A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	-	1.18.1.1,1.7.1.15	ko:K00362,ko:K05297	ko00071,ko00910,ko01120,map00071,map00910,map01120	M00530	R00787,R02000	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
HFD2_k127_7442537_1	543728.Vapar_3527	1.994e-250	786.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,2VH5K@28216|Betaproteobacteria,4AB2G@80864|Comamonadaceae	28216|Betaproteobacteria	KLT	protein phosphatase 2C domain protein	prkC2	-	2.7.11.1,3.1.3.16	ko:K01090,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PP2C_2,Pkinase,TPR_16,TPR_19,TPR_8
HFD2_k127_7442537_2	395495.Lcho_2676	2.068e-229	717.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KKE8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Major Facilitator Superfamily	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HFD2_k127_7442537_4	420662.Mpe_A2314	1.167e-91	321.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2VSMR@28216|Betaproteobacteria,1KJB1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,PilJ
HFD2_k127_7442537_3	864051.BurJ1DRAFT_3671	1.336e-96	328.0	COG2199@1|root,COG2199@2|Bacteria,1R1VQ@1224|Proteobacteria,2VPRA@28216|Betaproteobacteria,1KKEC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4
HFD2_k127_7442537_5	365044.Pnap_2371	1.229e-07	53.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,4ABTB@80864|Comamonadaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_7472258_6	395495.Lcho_1628	4.764e-64	222.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,1KJ8X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.3.8.7,1.5.5.2	ko:K00249,ko:K00294,ko:K13821	ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051	RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HFD2_k127_7472258_2	1286631.X805_08020	1.472e-108	358.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,1KJS2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HFD2_k127_7472258_7	395495.Lcho_2391	4.474e-62	219.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_7472258_0	983917.RGE_00870	4.618e-238	746.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1KKAP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.2,1.4.1.3	ko:K00260,ko:K00261	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD2_k127_7472258_8	397945.Aave_2599	1.912e-53	195.0	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,2WFV2@28216|Betaproteobacteria,4AJHJ@80864|Comamonadaceae	1224|Proteobacteria	P	PFAM superoxide dismutase, copper zinc binding	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HFD2_k127_7472258_1	395495.Lcho_3020	5.699e-112	365.0	COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2VQ9U@28216|Betaproteobacteria,1KKKQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_7472258_4	1033802.SSPSH_000968	7.778e-102	346.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_7472258_3	118166.JH976537_gene1662	2.176e-103	355.0	COG1123@1|root,COG4172@2|Bacteria,1GQP8@1117|Cyanobacteria,1HHYC@1150|Oscillatoriales	1117|Cyanobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HFD2_k127_7472258_5	1380387.JADM01000004_gene2810	5.12e-99	325.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1RMMR@1236|Gammaproteobacteria,1XIPC@135619|Oceanospirillales	135619|Oceanospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD2_k127_7487313_2	1218075.BAYA01000001_gene285	1.078e-66	228.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1K1SD@119060|Burkholderiaceae	28216|Betaproteobacteria	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HFD2_k127_7487313_1	983917.RGE_15180	4.06e-99	346.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2VI2D@28216|Betaproteobacteria,1KKBY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD2_k127_7487313_0	983917.RGE_15170	1.707e-151	502.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,1KJ4K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD2_k127_7487313_3	98439.AJLL01000098_gene1920	3.654e-50	189.0	COG4627@1|root,COG4627@2|Bacteria,1GKUS@1117|Cyanobacteria,1JMS3@1189|Stigonemataceae	1117|Cyanobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_7487313_4	983917.RGE_18440	2.701e-48	195.0	COG0642@1|root,COG2205@2|Bacteria,1RJWS@1224|Proteobacteria,2VSF7@28216|Betaproteobacteria,1KNIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HFD2_k127_7487313_6	596152.DesU5LDRAFT_1030	7.479e-31	140.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X189@28221|Deltaproteobacteria,2MEGD@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
HFD2_k127_7487313_5	1336243.JAEA01000007_gene863	2.093e-40	165.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,1JZGQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7507989_1	864051.BurJ1DRAFT_1264	2.583e-109	365.0	COG0760@1|root,COG0760@2|Bacteria,1R4EF@1224|Proteobacteria,2VK6Z@28216|Betaproteobacteria,1KITZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2,SurA_N_2,SurA_N_3
HFD2_k127_7507989_2	420662.Mpe_A2734	6.311e-104	348.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VIY9@28216|Betaproteobacteria,1KK25@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Polysaccharide biosynthesis/export protein	epsE	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD2_k127_7507989_0	864051.BurJ1DRAFT_1266	1.121e-150	490.0	COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2VHPS@28216|Betaproteobacteria,1KJ4B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Chain length determinant protein	gumC	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HFD2_k127_7507989_3	864051.BurJ1DRAFT_1267	3.349e-54	195.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,2VN0C@28216|Betaproteobacteria,1KJ2W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CbiA,GNVR,Wzz
HFD2_k127_7536379_5	68260.JOAY01000017_gene3450	3.138e-20	96.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	sigI	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD2_k127_7536379_3	234267.Acid_2804	1.885e-75	273.0	COG4299@1|root,COG4299@2|Bacteria,3Y2J9@57723|Acidobacteria	57723|Acidobacteria	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
HFD2_k127_7536379_0	543728.Vapar_3420	1.221e-261	818.0	COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria,4AH24@80864|Comamonadaceae	28216|Betaproteobacteria	P	Magnesium transport protein CorA	-	-	-	-	-	-	-	-	-	-	-	-	CorA
HFD2_k127_7536379_6	1286631.X805_17160	4.68e-12	70.0	2ESCC@1|root,33JX5@2|Bacteria,1NNFP@1224|Proteobacteria,2VXRI@28216|Betaproteobacteria,1KP2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7536379_1	1265502.KB905932_gene1903	2.501e-200	638.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,4ABG9@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
HFD2_k127_7536379_4	1223521.BBJX01000004_gene2308	1.903e-32	131.0	COG3133@1|root,COG3133@2|Bacteria,1N18D@1224|Proteobacteria,2VU4M@28216|Betaproteobacteria,4AF8T@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM 17 kDa surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HFD2_k127_7536379_2	614083.AWQR01000036_gene1297	1.948e-89	297.0	COG4799@1|root,COG4799@2|Bacteria,1NSRV@1224|Proteobacteria,2WI01@28216|Betaproteobacteria,4AK46@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,Carboxyl_trans
HFD2_k127_7540612_2	1163617.SCD_n00714	4.532e-60	211.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,2VPWE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7540612_1	987059.RBXJA2T_14916	1.265e-183	608.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VJ7D@28216|Betaproteobacteria,1KMS8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
HFD2_k127_7540612_0	987059.RBXJA2T_04463	1.547e-280	871.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VKXT@28216|Betaproteobacteria,1KJ5Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	nifA	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HFD2_k127_7552083_9	1265502.KB905949_gene943	1.715e-70	240.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,4ACEU@80864|Comamonadaceae	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HFD2_k127_7552083_0	420662.Mpe_A3167	4e-323	1020.0	COG0745@1|root,COG3447@1|root,COG3614@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3447@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGMG@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,MASE1,PAS,PAS_9,Response_reg
HFD2_k127_7552083_1	420662.Mpe_A3166	3.634e-209	653.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1KJJG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD2_k127_7552083_5	420662.Mpe_A0588	5.471e-118	405.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHUJ@28216|Betaproteobacteria,1KJGY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HFD2_k127_7552083_10	452637.Oter_0998	1.393e-54	203.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_7552083_6	420662.Mpe_A0589	1.45e-112	403.0	COG3217@1|root,COG3217@2|Bacteria,1MXN2@1224|Proteobacteria,2VI15@28216|Betaproteobacteria,1KIU1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	MOSC N-terminal beta barrel domain	ycbX	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HFD2_k127_7552083_2	420662.Mpe_A0590	2.019e-197	645.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,1KN49@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HFD2_k127_7552083_4	1286631.X805_35530	2.278e-145	469.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,1KJQI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family	ubiF	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,SE
HFD2_k127_7552083_7	1286631.X805_35520	7.48e-94	313.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1KJWI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
HFD2_k127_7552083_8	987059.RBXJA2T_15448	9.226e-90	300.0	COG0740@1|root,COG0740@2|Bacteria,1RBNX@1224|Proteobacteria,2VKY1@28216|Betaproteobacteria,1KPHF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD2_k127_7552083_3	420662.Mpe_A2574	6.777e-161	518.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1KKXW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	cioB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HFD2_k127_7552083_11	420662.Mpe_A2573	6.364e-33	130.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,1KJDA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HFD2_k127_7595855_8	1163617.SCD_n02428	1.646e-31	126.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	SMART alpha amylase, catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
HFD2_k127_7595855_6	1163617.SCD_n02429	1.831e-86	297.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HFD2_k127_7595855_5	987059.RBXJA2T_08685	7.769e-109	359.0	COG2267@1|root,COG2267@2|Bacteria,1R41P@1224|Proteobacteria,2VNV3@28216|Betaproteobacteria,1KNAN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD2_k127_7595855_3	864051.BurJ1DRAFT_2669	2.163e-115	377.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
HFD2_k127_7595855_1	864051.BurJ1DRAFT_2670	9.108e-149	490.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria,1KN20@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HFD2_k127_7595855_4	987059.RBXJA2T_19271	3.268e-114	375.0	COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2VJS5@28216|Betaproteobacteria,1KJ5V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD2_k127_7595855_0	420662.Mpe_A1918	0.0	1098.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1KJBB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD2_k127_7595855_2	1286631.X805_12520	1.129e-122	400.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,1KK3D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HFD2_k127_7595855_7	864051.BurJ1DRAFT_2674	5.918e-62	214.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,1KKVV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HFD2_k127_7595855_9	1458427.BAWN01000035_gene1966	6.057e-17	80.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4ABQS@80864|Comamonadaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HFD2_k127_7630570_0	1157708.KB907469_gene16	0.0	1555.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VN0R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_7655690_1	2002.JOEQ01000012_gene5766	4.276e-86	292.0	COG1028@1|root,COG1028@2|Bacteria,2IB1P@201174|Actinobacteria,4EP0W@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD2_k127_7655690_4	859657.RPSI07_0138	1.886e-57	202.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria,1K8EP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM glutathione-dependent formaldehyde-activating GFA	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD2_k127_7655690_6	983917.RGE_40770	4.703e-18	92.0	2ERQY@1|root,33JA6@2|Bacteria,1QUWX@1224|Proteobacteria,2WGWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7655690_0	420662.Mpe_A0140	3.993e-287	898.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2WGER@28216|Betaproteobacteria,1KME7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HFD2_k127_7655690_2	420662.Mpe_A0141	3.059e-85	291.0	2DBRJ@1|root,2ZAMD@2|Bacteria,1R498@1224|Proteobacteria,2VMV1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HFD2_k127_7655690_3	420662.Mpe_A0142	5.148e-60	212.0	2DK2X@1|root,3089T@2|Bacteria,1RF89@1224|Proteobacteria,2VR56@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_767861_8	864051.BurJ1DRAFT_1240	1.624e-51	189.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KITH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD2_k127_767861_2	420662.Mpe_A2745	2.573e-134	439.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,1KIZM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	peptidase	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD2_k127_767861_10	1265502.KB905938_gene2472	4.073e-27	113.0	COG4701@1|root,COG4701@2|Bacteria,1N5G9@1224|Proteobacteria,2VU6Y@28216|Betaproteobacteria,4AEVQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HFD2_k127_767861_7	395495.Lcho_0934	6.002e-62	217.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,1KKTI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HFD2_k127_767861_4	987059.RBXJA2T_06980	2.077e-123	398.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,1KKCU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HFD2_k127_767861_3	420662.Mpe_A0851	6.267e-124	424.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,1KJS7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HFD2_k127_767861_0	358220.C380_04505	2.672e-261	810.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4AAVH@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD2_k127_767861_5	391735.Veis_3935	5.725e-111	360.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HFD2_k127_767861_6	338969.Rfer_2428	5.718e-66	236.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,4ADW1@80864|Comamonadaceae	28216|Betaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HFD2_k127_767861_1	1265502.KB905938_gene2463	1.595e-209	684.0	COG3170@1|root,COG3170@2|Bacteria,1QV1N@1224|Proteobacteria,2WGRZ@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HFD2_k127_767861_9	1265502.KB905938_gene2462	1.028e-49	178.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,4ABB1@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HFD2_k127_7736809_5	864051.BurJ1DRAFT_1585	1.19e-80	273.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2VQKU@28216|Betaproteobacteria,1KKY0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
HFD2_k127_7736809_7	395495.Lcho_2921	6.316e-69	241.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VRAE@28216|Betaproteobacteria,1KKXP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD2_k127_7736809_4	398578.Daci_3944	1.033e-113	370.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,4AAQ9@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,PNP_phzG_C,Putative_PNPOx
HFD2_k127_7736809_6	420662.Mpe_A2934	4.411e-80	271.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2VR6F@28216|Betaproteobacteria,1KKV2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD2_k127_7736809_3	1095769.CAHF01000011_gene2142	2.843e-173	567.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,472S7@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	TonB dependent receptor	yncD	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_7736809_0	1123487.KB892867_gene954	1.041e-268	844.0	COG3533@1|root,COG4733@1|root,COG3533@2|Bacteria,COG4733@2|Bacteria,1NJBA@1224|Proteobacteria,2VNM3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Laminin_G_3
HFD2_k127_7736809_2	887062.HGR_12217	6.558e-196	651.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2VHDC@28216|Betaproteobacteria,4A9RK@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 2	opgH	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
HFD2_k127_7736809_1	292415.Tbd_1311	1.291e-212	673.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2VJBC@28216|Betaproteobacteria,1KRYY@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Periplasmic glucan biosynthesis protein, MdoG	-	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HFD2_k127_7770292_5	85643.Tmz1t_2389	5.858e-112	376.0	COG0642@1|root,COG0642@2|Bacteria,1QTVA@1224|Proteobacteria,2VJU7@28216|Betaproteobacteria,2KZYW@206389|Rhodocyclales	206389|Rhodocyclales	T	Member of a two-component regulatory system	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA
HFD2_k127_7770292_7	94624.Bpet2441	1.149e-87	299.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VQ03@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
HFD2_k127_7770292_10	983917.RGE_26350	1.477e-13	76.0	2C5IZ@1|root,33B4P@2|Bacteria,1NPIC@1224|Proteobacteria,2VVUV@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycine zipper 2TM domain	osmB	-	-	ko:K04062	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
HFD2_k127_7770292_4	1217718.ALOU01000076_gene3960	1.001e-137	448.0	COG4188@1|root,COG4188@2|Bacteria,1MW2N@1224|Proteobacteria,2VSKA@28216|Betaproteobacteria,1K3U9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Hydrolase_4,PAF-AH_p_II
HFD2_k127_7770292_6	1157708.KB907451_gene4601	2.439e-108	362.0	COG2207@1|root,COG2207@2|Bacteria,1P4M5@1224|Proteobacteria,2VY3J@28216|Betaproteobacteria	28216|Betaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HFD2_k127_7770292_9	987059.RBXJA2T_18969	8.776e-27	117.0	2C7M1@1|root,33I9V@2|Bacteria,1NNVG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
HFD2_k127_7770292_3	1265502.KB905955_gene483	5.636e-151	492.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2VPBZ@28216|Betaproteobacteria,4ABR3@80864|Comamonadaceae	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7770292_1	1265502.KB905955_gene482	3.519e-211	664.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VKAQ@28216|Betaproteobacteria,4ABTJ@80864|Comamonadaceae	28216|Betaproteobacteria	J	PFAM Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD2_k127_7770292_2	864051.BurJ1DRAFT_1515	2.562e-181	593.0	COG1629@1|root,COG4771@2|Bacteria,1QWIP@1224|Proteobacteria,2VKD5@28216|Betaproteobacteria,1KKH8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD2_k127_7770292_0	1265502.KB905955_gene481	1.279e-224	705.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VKA4@28216|Betaproteobacteria,4AC1M@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD2_k127_7770292_8	395495.Lcho_0031	9.402e-30	138.0	COG0810@1|root,COG0810@2|Bacteria,1P1KD@1224|Proteobacteria	1224|Proteobacteria	C	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7776797_0	375286.mma_0871	2.699e-140	465.0	COG0477@1|root,COG2814@2|Bacteria,1PE5A@1224|Proteobacteria,2VHTJ@28216|Betaproteobacteria,473JI@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	emrB_1	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD2_k127_7776797_5	1242864.D187_004417	6.245e-97	349.0	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,433UM@68525|delta/epsilon subdivisions,2XA3W@28221|Deltaproteobacteria,2YWAZ@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_7776797_7	1242864.D187_004418	9.419e-74	255.0	COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,438FQ@68525|delta/epsilon subdivisions,2X3QQ@28221|Deltaproteobacteria,2YWV7@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HFD2_k127_7776797_2	1254432.SCE1572_40920	3.674e-108	370.0	COG3576@1|root,COG3576@2|Bacteria,1QTUS@1224|Proteobacteria,43CW1@68525|delta/epsilon subdivisions,2X841@28221|Deltaproteobacteria,2YY4N@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD2_k127_7776797_1	977880.RALTA_A0022	3.819e-118	384.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VMAS@28216|Betaproteobacteria,1K1PJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD2_k127_7776797_8	395495.Lcho_4035	1.002e-50	188.0	COG3133@1|root,COG3133@2|Bacteria,1RJXC@1224|Proteobacteria,2VTKS@28216|Betaproteobacteria,1KKT0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	outer membrane lipoprotein	slyB	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
HFD2_k127_7776797_4	420662.Mpe_A0423	5.703e-100	347.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,1KIUW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD2_k127_7776797_3	420662.Mpe_A0420	6.962e-102	336.0	COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,2VKE3@28216|Betaproteobacteria,1KJ4I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	regulatory	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_7776797_6	1265502.KB905945_gene650	1.115e-80	269.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,4AB4R@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_7893427_1	864051.BurJ1DRAFT_4426	1.391e-223	696.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,1KIV5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD2_k127_7893427_2	983917.RGE_09520	7.728e-222	698.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,1KKFN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD2_k127_7893427_3	1265502.KB905949_gene961	3.355e-198	639.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,4ABEI@80864|Comamonadaceae	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD2_k127_7893427_4	365046.Rta_09700	1.643e-171	548.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,4AB8T@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD2_k127_7893427_0	1265502.KB905949_gene963	3.131e-241	771.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,4AA6E@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7893427_5	358220.C380_03760	9.179e-109	356.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,4AANC@80864|Comamonadaceae	28216|Betaproteobacteria	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD2_k127_7906501_7	397945.Aave_0816	2.613e-10	61.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,4AA27@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7906501_6	864051.BurJ1DRAFT_4428	1.066e-12	81.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,1KJT6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD2_k127_7906501_0	420662.Mpe_A0456	2.101e-286	895.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,1KJCM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_7906501_5	420662.Mpe_A0455	1.344e-24	110.0	COG3116@1|root,COG3116@2|Bacteria,1N95M@1224|Proteobacteria,2VVTP@28216|Betaproteobacteria,1KMIW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
HFD2_k127_7906501_1	864051.BurJ1DRAFT_4431	8.712e-141	454.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,1KJKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD2_k127_7906501_3	1538295.JY96_08045	4.069e-56	199.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2VRGP@28216|Betaproteobacteria,1KKYX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD2_k127_7906501_4	399795.CtesDRAFT_PD2379	1.351e-30	124.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HFD2_k127_7906501_2	365046.Rta_02050	1.117e-99	337.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,4AHNN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
HFD2_k127_7906501_8	1005395.CSV86_14841	0.0008146	43.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,1S2EW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HFD2_k127_7910974_2	1049564.TevJSym_ak00260	1.043e-145	476.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
HFD2_k127_7910974_0	381666.H16_A1621	4.783e-307	960.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HFD2_k127_7910974_3	1366050.N234_10790	3.393e-90	310.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria,1K39I@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD2_k127_7910974_1	1366046.HIMB11_02643	6.861e-182	578.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2V7UQ@28211|Alphaproteobacteria,3ZI5M@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	CH	Phenol hydroxylase, C-terminal dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Phe_hydrox_dim
HFD2_k127_7919911_9	420662.Mpe_A2702	2.914e-39	146.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,1KJEP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HFD2_k127_7919911_6	338969.Rfer_0119	1.417e-118	390.0	COG0583@1|root,COG0583@2|Bacteria,1R9IH@1224|Proteobacteria,2VZW5@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD2_k127_7919911_1	1286631.X805_31360	3.731e-196	618.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1KKAT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD2_k127_7919911_8	420662.Mpe_A2704	2.228e-93	310.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2VQ1Z@28216|Betaproteobacteria,1KKJK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD2_k127_7919911_5	420662.Mpe_A2705	4.898e-119	402.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,1KJ3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HFD2_k127_7919911_2	864051.BurJ1DRAFT_1664	2.842e-166	526.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,1KIYH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	phosphatase	pphA	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HFD2_k127_7919911_0	864051.BurJ1DRAFT_1663	3.017e-203	634.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,1KJQ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Serine threonine protein kinase	spkD	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HFD2_k127_7919911_4	983917.RGE_35510	1.775e-125	409.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,1KJSS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HFD2_k127_7919911_7	420662.Mpe_A2715	3.236e-105	344.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria,1KJ6J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HFD2_k127_7919911_10	983917.RGE_35670	7.953e-31	133.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2VVUH@28216|Betaproteobacteria,1KM8K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD2_k127_7919911_3	420662.Mpe_A2721	2.387e-160	510.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,1KJBQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_7925476_1	1265502.KB905945_gene650	4.636e-208	649.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,4AB4R@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HFD2_k127_7925476_3	1265502.KB905945_gene649	4.56e-53	206.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VS9I@28216|Betaproteobacteria,4AED0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HFD2_k127_7925476_0	1265502.KB905945_gene648	0.0	1380.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,4AAU6@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD2_k127_7925476_2	420662.Mpe_A0416	1.566e-162	543.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1KJKX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_7939753_1	420662.Mpe_A1125	1.411e-146	466.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,1KK0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_7939753_3	987059.RBXJA2T_09242	2.386e-129	416.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,1KJ0T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD2_k127_7939753_7	1123367.C666_16855	1.349e-05	52.0	COG0810@1|root,COG0810@2|Bacteria,1RJRA@1224|Proteobacteria,2VTFA@28216|Betaproteobacteria,2KYPW@206389|Rhodocyclales	206389|Rhodocyclales	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD2_k127_7939753_2	864051.BurJ1DRAFT_1705	2.152e-143	461.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,1KN0D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_7939753_0	1265502.KB905954_gene438	9.273e-180	585.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,4AAHK@80864|Comamonadaceae	28216|Betaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	ascD	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_7939753_4	1265502.KB905954_gene439	1.112e-127	427.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,4A9TJ@80864|Comamonadaceae	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	yeeZ	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N
HFD2_k127_7939753_5	420662.Mpe_A1129	1.275e-107	361.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2VPCV@28216|Betaproteobacteria,1KKFB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD2_k127_7939753_6	420662.Mpe_A1130	5.608e-84	281.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,1KKR5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Eukaryotic integral membrane protein (DUF1751)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD2_k127_7945426_17	522306.CAP2UW1_0900	1.044e-23	102.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2VMU5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HFD2_k127_7945426_12	983917.RGE_28620	2.423e-50	183.0	COG2197@1|root,COG2197@2|Bacteria,1NDQC@1224|Proteobacteria,2VRW4@28216|Betaproteobacteria,1KNSS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD2_k127_7945426_6	983917.RGE_10170	2.266e-111	362.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VHQ0@28216|Betaproteobacteria,1KJCT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	vsrD	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_7945426_4	987059.RBXJA2T_19396	7.244e-132	434.0	COG4585@1|root,COG5278@1|root,COG4585@2|Bacteria,COG5278@2|Bacteria,1MWPN@1224|Proteobacteria,2VJR2@28216|Betaproteobacteria,1KJV4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	CHASE3 domain	vsrA	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	CHASE3,HATPase_c,HisKA_3
HFD2_k127_7945426_19	420662.Mpe_A2904	8.376e-18	83.0	COG5487@1|root,COG5487@2|Bacteria,1PCW0@1224|Proteobacteria,2W9NB@28216|Betaproteobacteria,1KMU7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HFD2_k127_7945426_18	338969.Rfer_1876	4.336e-21	97.0	2ENJP@1|root,33G72@2|Bacteria,1NH5X@1224|Proteobacteria,2VY1D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7945426_10	543728.Vapar_4114	6.459e-82	280.0	COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,2VQHR@28216|Betaproteobacteria,4ADG1@80864|Comamonadaceae	28216|Betaproteobacteria	P	Ferritin, Dps family protein	bfr3	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD2_k127_7945426_14	338969.Rfer_4004	2.291e-35	139.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,2VUHT@28216|Betaproteobacteria,4AF5X@80864|Comamonadaceae	28216|Betaproteobacteria	S	SMART Transport-associated and nodulation region	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HFD2_k127_7945426_16	420662.Mpe_A2910	4.257e-29	119.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2VW2V@28216|Betaproteobacteria,1KNXM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HFD2_k127_7945426_13	402626.Rpic_3776	8.77e-42	171.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2VHC0@28216|Betaproteobacteria,1K4TN@119060|Burkholderiaceae	28216|Betaproteobacteria	T	AI-2E family transporter	yhhT	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_7945426_2	983917.RGE_13590	2.078e-190	621.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KK83@119065|unclassified Burkholderiales	28216|Betaproteobacteria	JKL	Belongs to the DEAD box helicase family	rhlE1	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HFD2_k127_7945426_5	864051.BurJ1DRAFT_2251	2.113e-118	386.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,1KKMW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HFD2_k127_7945426_15	864051.BurJ1DRAFT_2250	1.308e-30	121.0	2DNMC@1|root,32Y3R@2|Bacteria,1N8DI@1224|Proteobacteria,2VVNN@28216|Betaproteobacteria,1KMH0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2788
HFD2_k127_7945426_11	397945.Aave_1814	6.196e-66	246.0	COG1284@1|root,COG1284@2|Bacteria,1RDIV@1224|Proteobacteria,2VQSX@28216|Betaproteobacteria,4AE2N@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	YitT_membrane
HFD2_k127_7945426_3	1538295.JY96_19310	2.956e-140	448.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1KIVJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_7945426_1	420662.Mpe_A1869	9.013e-212	673.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1KJB6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_7945426_0	864051.BurJ1DRAFT_2247	6.526e-264	823.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,1KJB7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Poly(R)-hydroxyalkanoic acid synthase, class I	phbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
HFD2_k127_7945426_20	1286631.X805_01570	2.559e-17	85.0	2E3TT@1|root,32YR7@2|Bacteria,1N9R9@1224|Proteobacteria,2VW0P@28216|Betaproteobacteria,1KMJK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_7945426_9	864051.BurJ1DRAFT_2245	7.057e-89	299.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,1KKKZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HFD2_k127_7945426_7	864051.BurJ1DRAFT_2244	1.197e-105	357.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,1KJCG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	maleylacetoacetate isomerase	maiA	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
HFD2_k127_7945426_8	535289.Dtpsy_1677	5.204e-92	306.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,4AA1W@80864|Comamonadaceae	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HFD2_k127_7968008_1	1547437.LL06_03315	7.265e-241	762.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2TUA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
HFD2_k127_7968008_4	568706.BN118_2180	4.51e-163	522.0	COG0477@1|root,COG2814@2|Bacteria,1MUXC@1224|Proteobacteria,2VHYW@28216|Betaproteobacteria,3T3F2@506|Alcaligenaceae	28216|Betaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_7968008_5	760117.JN27_15060	8.452e-155	512.0	COG2072@1|root,COG2072@2|Bacteria,1QW8X@1224|Proteobacteria	1224|Proteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_3
HFD2_k127_7968008_11	926560.KE387027_gene410	3.746e-21	109.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	ywlB	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,C_GCAxxG_C_C
HFD2_k127_7968008_12	926567.TheveDRAFT_0341	1.303e-14	83.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD2_k127_7968008_3	395495.Lcho_3118	3.854e-194	611.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KJEN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium Bile acid symporter family	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD2_k127_7968008_7	395495.Lcho_3119	2.494e-91	301.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VPZB@28216|Betaproteobacteria,1KK59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HFD2_k127_7968008_8	395495.Lcho_3120	7.807e-85	285.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2VQPS@28216|Betaproteobacteria,1KKRE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	cadI	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD2_k127_7968008_10	864051.BurJ1DRAFT_0994	1.872e-46	169.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,1KMEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HFD2_k127_7968008_0	1157708.KB907462_gene900	0.0	1187.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HFD2_k127_7968008_9	29581.BW37_05073	4.332e-50	192.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2VT0Q@28216|Betaproteobacteria,47495@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD2_k127_7968008_6	420662.Mpe_A2067	3.638e-108	362.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,1KJCW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_7968008_2	395495.Lcho_4267	6.444e-207	666.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KK3U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD2_k127_7978055_5	1144275.COCOR_07583	1.136e-14	79.0	COG2764@1|root,COG2764@2|Bacteria,1RF2S@1224|Proteobacteria	1224|Proteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD2_k127_7978055_0	420662.Mpe_A2969	0.0	1078.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KJJ6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HFD2_k127_7978055_1	1123504.JQKD01000015_gene895	7.831e-218	683.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,4AAMJ@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	siaT_7	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_7978055_3	358220.C380_13685	3.51e-65	231.0	COG3090@1|root,COG3090@2|Bacteria,1N01Z@1224|Proteobacteria,2VRI7@28216|Betaproteobacteria,4ADWU@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_7978055_2	543728.Vapar_1609	4.493e-161	522.0	COG1638@1|root,COG1638@2|Bacteria,1MVYB@1224|Proteobacteria,2VIQ9@28216|Betaproteobacteria,4AA41@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP dicarboxylate transporter- DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_7978055_4	296591.Bpro_1771	7.477e-40	167.0	COG1794@1|root,COG1794@2|Bacteria,1MW3C@1224|Proteobacteria,2VSWN@28216|Betaproteobacteria,4AF9H@80864|Comamonadaceae	28216|Betaproteobacteria	M	racemase activity, acting on amino acids and derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_79981_2	1265502.KB905934_gene3223	1.811e-233	743.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,4A9Z5@80864|Comamonadaceae	28216|Betaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HFD2_k127_79981_13	1265502.KB905934_gene3224	7.021e-83	293.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae	28216|Betaproteobacteria	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD2_k127_79981_15	420662.Mpe_A3022	8.65e-77	279.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,1KKNJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Belongs to the DnaA family	hda	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
HFD2_k127_79981_11	420662.Mpe_A3023	1.899e-126	444.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,1KJUH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AI-2E family transporter	perM	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD2_k127_79981_10	420662.Mpe_A3024	3.122e-127	412.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,2VMIR@28216|Betaproteobacteria,1KKIU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HFD2_k127_79981_3	983917.RGE_13360	1.979e-221	698.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,1KK6B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD2_k127_79981_19	864051.BurJ1DRAFT_3108	7.658e-42	160.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,1KMD3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD2_k127_79981_20	864051.BurJ1DRAFT_3109	1.847e-41	157.0	COG0454@1|root,COG0456@2|Bacteria,1N7JM@1224|Proteobacteria,2VU1F@28216|Betaproteobacteria,1KM0F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Protein of unknown function (DUF3579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3579
HFD2_k127_79981_4	420662.Mpe_A3029	3.326e-219	688.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1KJFK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	acetylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD2_k127_79981_8	864051.BurJ1DRAFT_3111	3.155e-184	579.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,1KJGX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_79981_16	316055.RPE_3933	1.991e-75	261.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,2TSFT@28211|Alphaproteobacteria,3JSJA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HFD2_k127_79981_5	420662.Mpe_A3032	2.131e-210	664.0	COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2VM52@28216|Betaproteobacteria,1KIY5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,Usp
HFD2_k127_79981_18	1265502.KB905930_gene1453	5.676e-51	190.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2VSJ7@28216|Betaproteobacteria,4AE78@80864|Comamonadaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	abmE	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD2_k127_79981_1	504728.K649_11955	1.163e-245	787.0	COG0365@1|root,COG0365@2|Bacteria,1WNGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD2_k127_79981_7	859657.RPSI07_mp0052	4.475e-187	592.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2VIAN@28216|Betaproteobacteria,1K1BS@119060|Burkholderiaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	abmD	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_79981_9	1502852.FG94_01158	5.565e-129	432.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2VHSP@28216|Betaproteobacteria,475ZF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	abmC	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD2_k127_79981_17	504728.K649_11970	3.888e-52	194.0	COG1846@1|root,COG1846@2|Bacteria,1WMZ0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HFD2_k127_79981_0	267608.RSp0032	0.0	1256.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K008@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA	abmA	-	1.14.13.40,1.3.1.34	ko:K00219,ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HFD2_k127_79981_12	1286631.X805_15880	1.404e-99	328.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,2VHG4@28216|Betaproteobacteria,1KKD8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation	kynB	GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HFD2_k127_79981_6	1265502.KB905934_gene3236	2.966e-189	600.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2VIP0@28216|Betaproteobacteria,4AAXE@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HFD2_k127_79981_14	365046.Rta_27930	2.574e-81	275.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,4ACUT@80864|Comamonadaceae	28216|Betaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HFD2_k127_8013126_1	864051.BurJ1DRAFT_4900	1.231e-157	501.0	COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,2VIQ3@28216|Betaproteobacteria,1KJEU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	gudD	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_8013126_2	1286631.X805_36070	6.998e-149	477.0	COG3181@1|root,COG3181@2|Bacteria,1NP0J@1224|Proteobacteria,2VHTG@28216|Betaproteobacteria,1KJ1V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8013126_0	742159.HMPREF0004_3332	1.155e-180	571.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2VK61@28216|Betaproteobacteria,3T6ZJ@506|Alcaligenaceae	28216|Betaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	gnl	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD2_k127_8013126_4	1265502.KB905946_gene1169	6.912e-91	311.0	COG2186@1|root,COG2186@2|Bacteria,1R68P@1224|Proteobacteria,2VK2A@28216|Betaproteobacteria,4ADHU@80864|Comamonadaceae	28216|Betaproteobacteria	K	regulatory protein GntR HTH	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD2_k127_8013126_3	864051.BurJ1DRAFT_2438	7.993e-132	425.0	COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2VI2W@28216|Betaproteobacteria,1KK81@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Male sterility protein	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD2_k127_8013126_5	1458275.AZ34_14030	1.438e-20	93.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VKC6@28216|Betaproteobacteria,4AC8C@80864|Comamonadaceae	28216|Betaproteobacteria	G	TRAP dicarboxylate transporter	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HFD2_k127_8029418_8	420662.Mpe_A2261	3.015e-72	244.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1KKKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD2_k127_8029418_1	420662.Mpe_A2262	1.369e-240	747.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1KIUB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD2_k127_8029418_5	420662.Mpe_A2263	1.482e-101	333.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,1KK06@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HFD2_k127_8029418_10	987059.RBXJA2T_12592	7.46e-52	197.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,1KM3K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	ptpA	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HFD2_k127_8029418_0	1265502.KB905931_gene1709	0.0	1184.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,4AACI@80864|Comamonadaceae	28216|Betaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD2_k127_8029418_3	1265502.KB905931_gene1708	1.964e-199	627.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,4A9MF@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM aminotransferase, class I and II	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD2_k127_8029418_2	864051.BurJ1DRAFT_3641	1.251e-233	728.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2VIP8@28216|Betaproteobacteria,1KJ8R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Polyhydroxyalkanoate depolymerase, intracellular	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HFD2_k127_8029418_7	987059.RBXJA2T_12572	1.355e-93	316.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,1KKQJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
HFD2_k127_8029418_6	535289.Dtpsy_2517	9.071e-101	333.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2VIRB@28216|Betaproteobacteria,4AA3R@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD2_k127_8029418_12	420662.Mpe_A3340	3.197e-18	93.0	COG2203@1|root,COG2203@2|Bacteria,1NQAR@1224|Proteobacteria,2VYVY@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF
HFD2_k127_8029418_13	398578.Daci_2789	3.651e-16	92.0	2E3H4@1|root,32YFT@2|Bacteria,1N8PU@1224|Proteobacteria,2VVRT@28216|Betaproteobacteria,4AFD1@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ZapB
HFD2_k127_8029418_11	420662.Mpe_A2311	2.832e-37	143.0	COG3027@1|root,COG3027@2|Bacteria,1PTHR@1224|Proteobacteria,2VTX2@28216|Betaproteobacteria,1KME5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HFD2_k127_8029418_9	999541.bgla_1g31520	8.475e-68	235.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,1K4HB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD2_k127_8029418_4	1265502.KB905931_gene1697	6.388e-110	370.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,4ABTB@80864|Comamonadaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_8029474_2	864051.BurJ1DRAFT_4960	1.553e-117	378.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,1KJW1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD2_k127_8029474_1	987059.RBXJA2T_07693	6.393e-118	386.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1KJT7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD2_k127_8029474_3	420662.Mpe_A0081	9.205e-78	277.0	COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,1KKT1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Rod shape-determining protein mreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD2_k127_8029474_0	338969.Rfer_3920	1.59e-227	715.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD2_k127_8030995_4	987059.RBXJA2T_17449	1.32e-62	217.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,1KJH1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD2_k127_8030995_3	883126.HMPREF9710_04670	8.816e-100	338.0	COG3866@1|root,COG4677@1|root,COG3866@2|Bacteria,COG4677@2|Bacteria,1QPFF@1224|Proteobacteria,2VYRZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Pectate lyase	-	-	4.2.2.2	ko:K01728	ko00040,ko02024,map00040,map02024	-	R02361,R06240	RC00049,RC00705	ko00000,ko00001,ko01000	-	-	-	Pec_lyase_C
HFD2_k127_8030995_2	859657.RPSI07_mp0109	6.023e-153	492.0	COG2730@1|root,COG2730@2|Bacteria,1MV2T@1224|Proteobacteria,2VMFF@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	egl	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
HFD2_k127_8030995_1	543728.Vapar_4075	3.15e-192	604.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,4AA3H@80864|Comamonadaceae	28216|Betaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HFD2_k127_8030995_5	1538295.JY96_12255	1.082e-23	113.0	COG4249@1|root,COG4249@2|Bacteria,1PGX5@1224|Proteobacteria,2VUJ9@28216|Betaproteobacteria,1KP4B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8030995_0	864051.BurJ1DRAFT_4978	3.768e-248	807.0	COG2837@1|root,COG2837@2|Bacteria,1MXKF@1224|Proteobacteria,2VU6I@28216|Betaproteobacteria,1KNVU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Dyp-type peroxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Dyp_perox
HFD2_k127_8052977_6	1268622.AVS7_01668	1.158e-156	497.0	COG0395@1|root,COG0395@2|Bacteria,1MVRG@1224|Proteobacteria,2VKRQ@28216|Betaproteobacteria,4ABMW@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17323	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
HFD2_k127_8052977_5	1157708.KB907456_gene2480	1.375e-160	527.0	COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,2VINB@28216|Betaproteobacteria,4AA9E@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17322	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	BPD_transp_1
HFD2_k127_8052977_2	1265502.KB905968_gene1263	8.531e-173	549.0	COG3839@1|root,COG3839@2|Bacteria,1MU7W@1224|Proteobacteria,2VJWQ@28216|Betaproteobacteria,4ABWX@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K17325	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	ABC_tran,TOBE_2
HFD2_k127_8052977_3	1265502.KB905968_gene1264	1.237e-164	545.0	COG3839@1|root,COG3839@2|Bacteria,1MX8G@1224|Proteobacteria,2VKPS@28216|Betaproteobacteria,4AA8A@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K17324	ko02010,map02010	M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.35	-	-	ABC_tran,TOBE_2
HFD2_k127_8052977_1	1265502.KB905968_gene1265	1.1e-234	739.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,4AA35@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD dependent oxidoreductase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HFD2_k127_8052977_7	1265502.KB905968_gene1266	2.811e-132	425.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2VHRN@28216|Betaproteobacteria,4A9TT@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein DeoR	glpR	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
HFD2_k127_8052977_0	864051.BurJ1DRAFT_4569	3.988e-245	778.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,1KITK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD2_k127_8052977_4	1120705.FG95_02069	8.403e-162	533.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,2U3IV@28211|Alphaproteobacteria,2K1NC@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD2_k127_8052977_10	543728.Vapar_1826	7.523e-38	148.0	COG3324@1|root,COG3324@2|Bacteria,1N7Q5@1224|Proteobacteria,2VW31@28216|Betaproteobacteria,4AF4E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD2_k127_8052977_9	1123504.JQKD01000025_gene5907	3.248e-87	299.0	COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,2VP6N@28216|Betaproteobacteria,4ACSU@80864|Comamonadaceae	28216|Betaproteobacteria	K	Helix-turn-helix type 11 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HFD2_k127_8052977_8	257310.BB4471	1.368e-107	353.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,3T2GH@506|Alcaligenaceae	28216|Betaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_8068674_5	1267535.KB906767_gene3650	1.281e-19	89.0	COG0076@1|root,COG0076@2|Bacteria,3Y365@57723|Acidobacteria,2JP4F@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HFD2_k127_8068674_4	296591.Bpro_0100	3.572e-20	96.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VY9Z@28216|Betaproteobacteria,4AFU1@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM zinc finger, DksA TraR C4-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD2_k127_8068674_0	68219.JNXI01000054_gene182	0.0	1059.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria	201174|Actinobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HFD2_k127_8068674_3	1054860.KB913030_gene6037	1.671e-20	103.0	29132@1|root,2ZNQK@2|Bacteria,2IRWX@201174|Actinobacteria	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD2_k127_8068674_2	983917.RGE_46070	1.624e-86	290.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2VNUN@28216|Betaproteobacteria,1KKKC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD2_k127_8068674_1	338969.Rfer_0843	3.85e-220	684.0	COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,2VH6E@28216|Betaproteobacteria,4AA3B@80864|Comamonadaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.81	ko:K22209	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_8089646_2	1380394.JADL01000007_gene4685	2.431e-114	376.0	COG2378@1|root,COG2378@2|Bacteria,1PXCX@1224|Proteobacteria,2TTKZ@28211|Alphaproteobacteria,2JVC2@204441|Rhodospirillales	204441|Rhodospirillales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HFD2_k127_8089646_5	1234364.AMSF01000025_gene3620	5.097e-53	207.0	COG1359@1|root,COG1359@2|Bacteria,1REMS@1224|Proteobacteria,1TI3B@1236|Gammaproteobacteria,1X7PQ@135614|Xanthomonadales	135614|Xanthomonadales	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD2_k127_8089646_4	614083.AWQR01000025_gene3749	1.269e-56	225.0	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,4ADKC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HFD2_k127_8089646_1	420662.Mpe_A1369	1.678e-125	410.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2VHTU@28216|Betaproteobacteria,1KJK3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF808)	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
HFD2_k127_8089646_7	398525.KB900701_gene7229	1.815e-22	112.0	COG4995@1|root,COG4995@2|Bacteria,1R6PK@1224|Proteobacteria,2U09I@28211|Alphaproteobacteria,3JWPV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HFD2_k127_8089646_9	1267534.KB906757_gene842	2.712e-10	73.0	COG0457@1|root,COG0457@2|Bacteria	1267534.KB906757_gene842|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8089646_8	983917.RGE_38630	5.639e-21	94.0	2E7T6@1|root,3328B@2|Bacteria,1N8UT@1224|Proteobacteria,2VVWC@28216|Betaproteobacteria,1KMKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8089646_0	1408164.MOLA814_00047	1.818e-195	622.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1KPQ3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_8089646_6	1123277.KB893195_gene5768	8.648e-31	131.0	COG0702@1|root,COG0702@2|Bacteria,4NMI5@976|Bacteroidetes,47R0K@768503|Cytophagia	976|Bacteroidetes	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HFD2_k127_8089646_3	62928.azo0660	6.268e-70	238.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales	206389|Rhodocyclales	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
HFD2_k127_8101587_3	498211.CJA_0422	1.377e-74	255.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1FHRD@10|Cellvibrio	1236|Gammaproteobacteria	S	Phosphatidylethanolamine-binding protein	ybcL	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD2_k127_8101587_6	305700.B447_00730	3.534e-33	132.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,2VVVU@28216|Betaproteobacteria,2KZ7R@206389|Rhodocyclales	206389|Rhodocyclales	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HFD2_k127_8101587_5	864051.BurJ1DRAFT_3348	2.968e-33	130.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HFD2_k127_8101587_2	864051.BurJ1DRAFT_3347	1.614e-86	287.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2VS0Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HFD2_k127_8101587_1	864051.BurJ1DRAFT_3346	1.288e-168	537.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1KNC0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD2_k127_8101587_4	765912.Thimo_3548	3.794e-71	259.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8101587_9	1123393.KB891331_gene2946	7.428e-16	84.0	2BW2S@1|root,32QYV@2|Bacteria,1RI5M@1224|Proteobacteria,2VX7W@28216|Betaproteobacteria,1KT27@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8101587_10	864051.BurJ1DRAFT_3344	3.264e-13	80.0	2DRY7@1|root,33DN9@2|Bacteria,1NJPX@1224|Proteobacteria,2VYHU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8101587_7	864051.BurJ1DRAFT_3343	6.786e-32	136.0	COG1974@1|root,COG1974@2|Bacteria,1QUQ8@1224|Proteobacteria,2VWS0@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
HFD2_k127_8101587_0	864051.BurJ1DRAFT_3342	2.836e-206	651.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
HFD2_k127_8101587_8	580332.Slit_1692	6.897e-28	113.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria,44W7U@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HFD2_k127_8103834_3	987059.RBXJA2T_05188	5.884e-35	133.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,1KIZE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HFD2_k127_8103834_2	596153.Alide_4209	1.978e-71	249.0	28M8G@1|root,2ZAMM@2|Bacteria,1MVBT@1224|Proteobacteria,2VRKU@28216|Betaproteobacteria,4AF7E@80864|Comamonadaceae	28216|Betaproteobacteria	S	RES domain	-	-	-	-	-	-	-	-	-	-	-	-	RES
HFD2_k127_8103834_4	596153.Alide_4208	3.875e-30	139.0	COG5642@1|root,COG5642@2|Bacteria,1N2DF@1224|Proteobacteria,2VUY5@28216|Betaproteobacteria,4AFQT@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HFD2_k127_8103834_1	395495.Lcho_1613	6.579e-136	438.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1KJ1G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD2_k127_8103834_0	395495.Lcho_3031	4.43e-149	480.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VK3H@28216|Betaproteobacteria,1KIWB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Amidase	atzF	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
HFD2_k127_8130193_3	543728.Vapar_2124	5.413e-85	290.0	COG3181@1|root,COG3181@2|Bacteria,1MWSC@1224|Proteobacteria,2VZGI@28216|Betaproteobacteria,4AH6N@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8130193_1	864051.BurJ1DRAFT_0619	6.777e-115	377.0	COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,2VNFR@28216|Betaproteobacteria,1KNBE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
HFD2_k127_8130193_2	864051.BurJ1DRAFT_0615	9.116e-114	371.0	COG1994@1|root,COG1994@2|Bacteria,1PM1Q@1224|Proteobacteria,2VM3E@28216|Betaproteobacteria,1KKDC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8130193_4	1353531.AZNX01000003_gene2649	4.645e-66	231.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,4BJQ0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HFD2_k127_8130193_0	864051.BurJ1DRAFT_4619	7.596e-146	492.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2W9V4@28216|Betaproteobacteria,1KMME@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Malate/L-lactate dehydrogenase	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
HFD2_k127_8130193_5	29581.BW37_02284	4.596e-46	171.0	COG1765@1|root,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2VTHB@28216|Betaproteobacteria,4779N@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HFD2_k127_8130193_6	420662.Mpe_A2192	1.787e-27	115.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria,1KKAD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	import inner membrane translocase subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HFD2_k127_8132784_0	864051.BurJ1DRAFT_4413	0.0	2147.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD2_k127_8132784_1	1101195.Meth11DRAFT_0831	1.189e-207	689.0	COG1572@1|root,COG1858@1|root,COG3103@1|root,COG3210@1|root,COG3391@1|root,COG3979@1|root,COG5295@1|root,COG1572@2|Bacteria,COG1858@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3979@2|Bacteria,COG4991@2|Bacteria,COG5295@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,2KNCT@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Di-haem cytochrome c peroxidase	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
HFD2_k127_8138602_5	864051.BurJ1DRAFT_0218	2.725e-67	233.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,2VMMY@28216|Betaproteobacteria,1KKHK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	frk	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HFD2_k127_8138602_0	864051.BurJ1DRAFT_0217	1.809e-180	569.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2VJFU@28216|Betaproteobacteria,1KK9G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439,ko:K10552	ko02010,ko02030,map02010,map02030	M00212,M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.7	-	-	Peripla_BP_4
HFD2_k127_8138602_1	395495.Lcho_2222	2.948e-160	520.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2VJ3R@28216|Betaproteobacteria,1KKBV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K10553	ko02010,map02010	M00212,M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.7	-	-	BPD_transp_2
HFD2_k127_8138602_4	395495.Lcho_2223	4.794e-134	448.0	COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,2VID6@28216|Betaproteobacteria,1KJQC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	ATPases associated with a variety of cellular activities	rbsA	-	-	ko:K10554	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	ABC_tran
HFD2_k127_8138602_6	864051.BurJ1DRAFT_0214	2.953e-52	201.0	COG4154@1|root,COG4154@2|Bacteria,1RJ03@1224|Proteobacteria,2VRIG@28216|Betaproteobacteria,1KKTG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the RbsD FucU family	-	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
HFD2_k127_8138602_2	29581.BW37_00756	4.792e-156	511.0	COG1940@1|root,COG1940@2|Bacteria,1MVGQ@1224|Proteobacteria,2VHF5@28216|Betaproteobacteria,4768B@75682|Oxalobacteraceae	28216|Betaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
HFD2_k127_8138602_3	864051.BurJ1DRAFT_0207	1.177e-137	450.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VKV7@28216|Betaproteobacteria,1KJ0Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CH	UbiH UbiF VisC COQ6 family	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HFD2_k127_8145838_2	864051.BurJ1DRAFT_2239	3.142e-72	267.0	COG1361@1|root,COG2304@1|root,COG2931@1|root,COG2982@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF4347,He_PIG,HemolysinCabind,VWA_2
HFD2_k127_8145838_3	1538295.JY96_20245	1.078e-14	88.0	COG2304@1|root,COG2730@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2730@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2
HFD2_k127_8145838_1	395495.Lcho_2093	6.896e-186	622.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,1KJGG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HFD2_k127_8145838_0	864051.BurJ1DRAFT_2241	0.0	1028.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,1KITV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	TIGRFAM type I secretion system ATPase	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HFD2_k127_8148192_13	864051.BurJ1DRAFT_3891	6.879e-24	100.0	COG1175@1|root,COG1175@2|Bacteria,1P9M5@1224|Proteobacteria,2VKR9@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HFD2_k127_8148192_5	1157708.KB907453_gene4337	2.787e-157	501.0	COG0395@1|root,COG0395@2|Bacteria,1QW7F@1224|Proteobacteria,2VNE8@28216|Betaproteobacteria,4AD43@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HFD2_k127_8148192_2	296591.Bpro_3526	1.61e-182	576.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4A9W1@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_8148192_12	1206729.BAFZ01000054_gene3063	7.76e-52	188.0	COG3265@1|root,COG3265@2|Bacteria,2GMW2@201174|Actinobacteria,4G1F4@85025|Nocardiaceae	201174|Actinobacteria	G	Gluconokinase	gntK	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
HFD2_k127_8148192_6	864051.BurJ1DRAFT_3887	2.482e-113	379.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	kduD	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_8148192_11	1458275.AZ34_05530	1.771e-54	193.0	2AN43@1|root,31D1U@2|Bacteria,1RICI@1224|Proteobacteria,2VT3P@28216|Betaproteobacteria,4AE91@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8148192_7	365046.Rta_11500	3.672e-113	370.0	COG2186@1|root,COG2186@2|Bacteria,1MV83@1224|Proteobacteria,2VHMI@28216|Betaproteobacteria,4AB8D@80864|Comamonadaceae	28216|Betaproteobacteria	K	regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_8148192_10	196367.JNFG01000201_gene2810	9.976e-79	296.0	COG3897@1|root,COG3897@2|Bacteria,1MUWA@1224|Proteobacteria,2VQPT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16,Methyltransf_23
HFD2_k127_8148192_0	864051.BurJ1DRAFT_2679	5.149e-240	749.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VJ87@28216|Betaproteobacteria,1KK2D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate	dctA	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
HFD2_k127_8148192_3	1348657.M622_07775	9.676e-179	572.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VKYV@28216|Betaproteobacteria,2KV04@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HFD2_k127_8148192_4	1500894.JQNN01000001_gene3041	5.099e-170	554.0	COG4529@1|root,COG4529@2|Bacteria,1R7T8@1224|Proteobacteria,2W2X9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	FAD-NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8148192_9	1051646.VITU9109_09237	4.744e-108	375.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,1S3AB@1236|Gammaproteobacteria,1XW9M@135623|Vibrionales	135623|Vibrionales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
HFD2_k127_8148192_8	1265502.KB905934_gene3277	4.702e-113	376.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VI4C@28216|Betaproteobacteria,4ABPE@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HFD2_k127_8148192_1	1380391.JIAS01000001_gene2611	2.808e-228	713.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,2JVSY@204441|Rhodospirillales	204441|Rhodospirillales	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD2_k127_8159073_3	983917.RGE_21710	3.291e-139	444.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KJP2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD2_k127_8159073_5	640511.BC1002_4297	1.132e-132	435.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2VI1A@28216|Betaproteobacteria,1K12V@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
HFD2_k127_8159073_1	748247.AZKH_0191	2.94e-237	743.0	COG0477@1|root,COG1359@1|root,COG0477@2|Bacteria,COG1359@2|Bacteria,1MXZ3@1224|Proteobacteria,2VH3E@28216|Betaproteobacteria,2KZWH@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD2_k127_8159073_2	1265502.KB905961_gene327	1.173e-168	539.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2VIAD@28216|Betaproteobacteria,4A9Z7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
HFD2_k127_8159073_4	388051.AUFE01000005_gene1083	2.973e-137	444.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM3I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8159073_0	595537.Varpa_1349	6.811e-274	850.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,4AB1S@80864|Comamonadaceae	28216|Betaproteobacteria	E	gamma-glutamyltransferase	ggt1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD2_k127_8159073_6	983917.RGE_28570	1.738e-17	92.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,1KMEP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HFD2_k127_8188879_5	987059.RBXJA2T_09782	8.96e-85	288.0	COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria,1KKRA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Pkinase
HFD2_k127_8188879_1	983917.RGE_33010	5.74e-199	624.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1KKDQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD2_k127_8188879_0	420662.Mpe_A2534	4.458e-227	719.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,1KJYI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
HFD2_k127_8188879_6	395495.Lcho_1975	3.105e-53	189.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,1KM4W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HFD2_k127_8188879_4	420662.Mpe_A2532	1.935e-93	312.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2VJVJ@28216|Betaproteobacteria,1KJ29@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HFD2_k127_8188879_2	420662.Mpe_A2530	2.546e-188	618.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,1KJ2P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	lytic transglycosylase	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HFD2_k127_8188879_3	864051.BurJ1DRAFT_2479	5.105e-114	376.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,1KJIT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HFD2_k127_8188879_7	296591.Bpro_2280	3.352e-25	106.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,4ACT7@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD2_k127_8208659_1	864051.BurJ1DRAFT_1529	9.515e-108	356.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2VJ4X@28216|Betaproteobacteria,1KJ6E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_8208659_0	864051.BurJ1DRAFT_1530	2.488e-215	674.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2VHEX@28216|Betaproteobacteria,1KKBZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_8208659_5	864051.BurJ1DRAFT_1531	1.826e-50	186.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2W2SU@28216|Betaproteobacteria,1KNNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_8208659_2	1286631.X805_02120	1.703e-79	269.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,1KKJR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_8208659_4	395495.Lcho_0458	5.101e-66	241.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2VQHC@28216|Betaproteobacteria,1KKZG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_8208659_3	987059.RBXJA2T_15338	2.343e-75	264.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,1KKPZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome B561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HFD2_k127_8208659_6	358220.C380_23050	8.557e-21	92.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,4AC8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_8222940_9	887062.HGR_10345	3.035e-33	134.0	COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2VQ3C@28216|Betaproteobacteria,4AF28@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD2_k127_8222940_5	1538295.JY96_17200	1.123e-98	337.0	COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,2VMS5@28216|Betaproteobacteria,1KKXB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF898)	-	-	-	-	-	-	-	-	-	-	-	-	DUF898
HFD2_k127_8222940_4	983917.RGE_45430	1.058e-104	343.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,1KJKI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase	yibF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD2_k127_8222940_10	864051.BurJ1DRAFT_4701	3.469e-20	107.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
HFD2_k127_8222940_0	420662.Mpe_A3620	2.019e-280	893.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VKQG@28216|Betaproteobacteria,1KIXH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the glutamate synthase family	glt	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
HFD2_k127_8222940_7	1268622.AVS7_01985	1.94e-74	267.0	COG0683@1|root,COG0683@2|Bacteria,1NRM9@1224|Proteobacteria,2W0E0@28216|Betaproteobacteria,4AGF0@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular liganD-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD2_k127_8222940_2	358220.C380_22215	5.097e-131	442.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2VIJK@28216|Betaproteobacteria,4ABT2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD2_k127_8222940_1	296591.Bpro_3454	1.56e-150	502.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,4AE7I@80864|Comamonadaceae	28216|Betaproteobacteria	V	PFAM ABC-2 type transporter	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD2_k127_8222940_3	1244869.H261_01701	1.791e-126	420.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2JYV7@204441|Rhodospirillales	204441|Rhodospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD2_k127_8222940_6	1121127.JAFA01000004_gene1216	4.012e-79	277.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2VNQ2@28216|Betaproteobacteria,1K0P5@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD2_k127_8222940_8	296591.Bpro_3451	2.611e-34	140.0	COG1309@1|root,COG1309@2|Bacteria,1NDUF@1224|Proteobacteria,2VXMY@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD2_k127_8228756_1	1265502.KB905931_gene1647	1.738e-162	519.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,4A9M7@80864|Comamonadaceae	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD2_k127_8228756_3	338969.Rfer_2755	2.373e-87	304.0	COG2206@1|root,COG2206@2|Bacteria,1MWDU@1224|Proteobacteria,2VIAF@28216|Betaproteobacteria,4AEGU@80864|Comamonadaceae	28216|Betaproteobacteria	T	phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
HFD2_k127_8228756_2	983917.RGE_14780	8.308e-103	347.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,1KJ7C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HFD2_k127_8228756_0	1379270.AUXF01000001_gene1943	1.896e-169	544.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
HFD2_k127_8228756_4	1095769.CAHF01000022_gene349	5.1e-83	278.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VPP7@28216|Betaproteobacteria,4724Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HFD2_k127_8233834_4	76114.ebA1117	4.635e-78	271.0	COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria,2KXU7@206389|Rhodocyclales	206389|Rhodocyclales	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
HFD2_k127_8233834_0	420662.Mpe_A1814	2.25e-161	516.0	COG2850@1|root,COG2850@2|Bacteria,1RDTN@1224|Proteobacteria,2VW2Z@28216|Betaproteobacteria,1KP2S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	JmjC domain, hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
HFD2_k127_8233834_2	29581.BW37_02554	4.48e-108	361.0	COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,473DK@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_8233834_1	420662.Mpe_A2032	3.023e-109	360.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2VJF9@28216|Betaproteobacteria,1KJZE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD2_k127_8233834_3	1265502.KB905931_gene1647	3.756e-91	303.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,4A9M7@80864|Comamonadaceae	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD2_k127_8268537_0	1157708.KB907450_gene6512	7.918e-103	348.0	COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VM24@28216|Betaproteobacteria,4ABN5@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.55	ko:K10674	ko00260,ko01120,map00260,map01120	-	R08050	RC00661	ko00000,ko00001,ko01000	-	-	-	PhyH
HFD2_k127_8268537_2	365046.Rta_12720	3.643e-82	279.0	COG1802@1|root,COG1802@2|Bacteria,1MY2M@1224|Proteobacteria,2VK5T@28216|Betaproteobacteria,4ADUT@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_8268537_3	420662.Mpe_A0531	7.773e-59	215.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,1KKYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Hemolysin III	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HFD2_k127_8268537_4	1123504.JQKD01000002_gene3971	7.963e-17	83.0	2E7T6@1|root,3328B@2|Bacteria,1N8UT@1224|Proteobacteria,2VVWC@28216|Betaproteobacteria,4AG0G@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8268537_1	460265.Mnod_3029	2.467e-91	320.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U17W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_7,Response_reg
HFD2_k127_8278450_0	987059.RBXJA2T_16677	0.0	1043.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1KJY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD2_k127_8278450_4	395495.Lcho_1237	2.347e-169	538.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,1KIYV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HFD2_k127_8278450_7	1286631.X805_35150	9.344e-129	423.0	COG3284@1|root,COG3284@2|Bacteria,1Q5BU@1224|Proteobacteria,2VJEK@28216|Betaproteobacteria,1KK9K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8
HFD2_k127_8278450_1	1286631.X805_35160	3.012e-306	970.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,1KNF6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HFD2_k127_8278450_10	1286631.X805_35170	3.545e-34	145.0	COG2010@1|root,COG2010@2|Bacteria,1RDPD@1224|Proteobacteria,2VYFE@28216|Betaproteobacteria,1KP82@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD2_k127_8278450_9	987059.RBXJA2T_16692	1.305e-108	359.0	COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,2VIXH@28216|Betaproteobacteria,1KJ40@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD2_k127_8278450_3	358220.C380_06625	1.03e-180	578.0	COG1075@1|root,COG1075@2|Bacteria,1MWM9@1224|Proteobacteria,2VN20@28216|Betaproteobacteria,4ACT5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_2
HFD2_k127_8278450_6	1156919.QWC_03453	6.954e-129	420.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2VHM1@28216|Betaproteobacteria	28216|Betaproteobacteria	EQ	PFAM peptidase S58, DmpA	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HFD2_k127_8278450_5	983917.RGE_14070	7.247e-167	537.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,1KJJR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_8278450_2	365046.Rta_31740	3.505e-223	697.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,4A9NJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD2_k127_8278450_11	983917.RGE_10050	2.809e-33	148.0	2DQCN@1|root,32UNU@2|Bacteria,1N0Q0@1224|Proteobacteria,2VUZ3@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8278450_8	1458275.AZ34_05950	2.725e-121	393.0	COG3181@1|root,COG3181@2|Bacteria,1N00G@1224|Proteobacteria,2VN46@28216|Betaproteobacteria,4ADS3@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8279303_1	1265502.KB905937_gene2541	7.308e-138	451.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2W1GY@28216|Betaproteobacteria,4AK4Y@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_8279303_3	443598.AUFA01000007_gene4605	7.96e-98	331.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,2V9KT@28211|Alphaproteobacteria,3JU43@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD2_k127_8279303_2	864051.BurJ1DRAFT_3848	6.249e-112	388.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KKRR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Pkinase
HFD2_k127_8279303_4	1458275.AZ34_14365	1.271e-48	196.0	COG0847@1|root,COG0847@2|Bacteria,1RHD8@1224|Proteobacteria,2VSET@28216|Betaproteobacteria,4AHY1@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8279303_0	1124983.PFLCHA0_c15110	5.853e-198	627.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YMFS@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	IQ	Long-chain fatty acid--CoA ligase	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD2_k127_8280270_3	1123504.JQKD01000013_gene1021	1.576e-84	282.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,2VQI0@28216|Betaproteobacteria,4AE5G@80864|Comamonadaceae	28216|Betaproteobacteria	L	TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HFD2_k127_8280270_1	395495.Lcho_3569	3.253e-201	634.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2VKK1@28216|Betaproteobacteria,1KJ3K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM phenylacetate-CoA oxygenase reductase, PaaK subunit	paaE	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD2_k127_8280270_2	1123504.JQKD01000013_gene1019	1.53e-84	285.0	COG1309@1|root,COG1309@2|Bacteria,1QYD4@1224|Proteobacteria,2VMMD@28216|Betaproteobacteria,4ADMH@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	paaR	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD2_k127_8280270_0	543728.Vapar_1226	0.0	1155.0	COG1012@1|root,COG2030@1|root,COG1012@2|Bacteria,COG2030@2|Bacteria,1MWD4@1224|Proteobacteria,2VH7K@28216|Betaproteobacteria,4AGME@80864|Comamonadaceae	28216|Betaproteobacteria	CI	MaoC like domain	paaN	-	1.2.1.91,3.3.2.12	ko:K02618	ko00360,ko01120,map00360,map01120	-	R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000	-	-	-	Aldedh,MaoC_dehydratas
HFD2_k127_8280270_4	1286631.X805_25030	6.454e-59	209.0	COG1522@1|root,COG1522@2|Bacteria,1RJ7F@1224|Proteobacteria,2VTCR@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
HFD2_k127_8280270_5	595537.Varpa_1088	8.512e-39	149.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,4AC8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HFD2_k127_8306660_2	1157708.KB907457_gene2609	1.244e-115	379.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,4AB55@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.39,1.2.1.8	ko:K00130,ko:K00146	ko00260,ko00360,ko00643,ko01100,ko01120,map00260,map00360,map00643,map01100,map01120	M00555	R02536,R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD2_k127_8306660_0	1157708.KB907457_gene2610	1.054e-189	594.0	28IZD@1|root,2Z8WU@2|Bacteria,1NEGQ@1224|Proteobacteria,2VNRH@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8306660_4	543728.Vapar_6128	1.231e-80	271.0	28PSM@1|root,2ZCE4@2|Bacteria,1RBR6@1224|Proteobacteria,2VQIJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8306660_1	543728.Vapar_6127	1.42e-127	415.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ7S@28216|Betaproteobacteria,4AI4F@80864|Comamonadaceae	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_8306660_5	748247.AZKH_4465	3.615e-34	145.0	COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8306660_3	666685.R2APBS1_0263	2.639e-112	394.0	COG2203@1|root,COG3576@1|root,COG2203@2|Bacteria,COG3576@2|Bacteria,1PP8V@1224|Proteobacteria,1RYJ4@1236|Gammaproteobacteria,1XA21@135614|Xanthomonadales	135614|Xanthomonadales	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
HFD2_k127_8319049_11	715226.ABI_16360	5.488e-62	220.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,2KH7Z@204458|Caulobacterales	204458|Caulobacterales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD2_k127_8319049_8	864051.BurJ1DRAFT_2118	2.78e-100	338.0	COG1917@1|root,COG1917@2|Bacteria,1MUY3@1224|Proteobacteria,2VQRV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	1.13.11.41	ko:K05913	ko00363,ko01120,map00363,map01120	-	R01305	RC00415,RC01565	ko00000,ko00001,ko01000	-	-	-	Cupin_7
HFD2_k127_8319049_6	864051.BurJ1DRAFT_2117	3.537e-110	377.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28	ko:K00034,ko:K00046,ko:K00059,ko:K00216	ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212	M00083,M00572	R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD2_k127_8319049_0	1265502.KB905970_gene1301	6.448e-227	724.0	COG3386@1|root,COG3386@2|Bacteria,1NIN4@1224|Proteobacteria,2VWDJ@28216|Betaproteobacteria,4AFEK@80864|Comamonadaceae	28216|Betaproteobacteria	G	Major royal jelly protein	-	-	-	-	-	-	-	-	-	-	-	-	MRJP
HFD2_k127_8319049_5	1265502.KB905970_gene1300	7.921e-120	403.0	COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2VKA3@28216|Betaproteobacteria,4ACV6@80864|Comamonadaceae	28216|Betaproteobacteria	G	pfkB family carbohydrate kinase	kdgK	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HFD2_k127_8319049_7	365046.Rta_11240	1.859e-101	350.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VXA0@28216|Betaproteobacteria,4AFEJ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Pfam:Methyltransf_6	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HFD2_k127_8319049_4	365046.Rta_11230	1.005e-145	485.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2WHKK@28216|Betaproteobacteria,4AEQ6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_8319049_3	365046.Rta_11220	7.184e-164	542.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,4AGXE@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_8319049_1	365046.Rta_11210	2.429e-213	670.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4ACPD@80864|Comamonadaceae	28216|Betaproteobacteria	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_8319049_10	365046.Rta_11200	8.07e-67	231.0	COG3090@1|root,COG3090@2|Bacteria,1RAZ5@1224|Proteobacteria,2VQ8J@28216|Betaproteobacteria,4ADJZ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_8319049_9	1265502.KB905970_gene1294	5.555e-83	281.0	COG1802@1|root,COG1802@2|Bacteria,1MW2A@1224|Proteobacteria,2WEVT@28216|Betaproteobacteria,4AFS1@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_8319049_2	420662.Mpe_A1578	2.795e-213	668.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,1KIXB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_8328982_0	1000565.METUNv1_00046	2.404e-157	512.0	COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales	206389|Rhodocyclales	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT
HFD2_k127_8328982_2	84531.JMTZ01000079_gene2184	7.419e-71	247.0	COG1670@1|root,COG1670@2|Bacteria,1RKKE@1224|Proteobacteria,1S47R@1236|Gammaproteobacteria,1X7VY@135614|Xanthomonadales	135614|Xanthomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD2_k127_8328982_1	420662.Mpe_A1486	9.644e-115	381.0	COG4249@1|root,COG4249@2|Bacteria,1R45G@1224|Proteobacteria,2WEWV@28216|Betaproteobacteria,1KJ4W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HFD2_k127_8328982_4	497321.C664_08143	6.311e-60	215.0	COG0457@1|root,COG0457@2|Bacteria,1R48M@1224|Proteobacteria,2VJUM@28216|Betaproteobacteria,2KYRV@206389|Rhodocyclales	206389|Rhodocyclales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8328982_3	864051.BurJ1DRAFT_3534	1.302e-60	228.0	2BVVW@1|root,32175@2|Bacteria,1QZ0X@1224|Proteobacteria,2VSMJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HFD2_k127_8328982_5	420662.Mpe_A3528	1.432e-32	129.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,1KKH7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD2_k127_8348442_26	358220.C380_02385	3.706e-07	56.0	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,2VUY4@28216|Betaproteobacteria,4AE71@80864|Comamonadaceae	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_8348442_23	1442599.JAAN01000005_gene928	3.884e-33	136.0	COG3094@1|root,COG3094@2|Bacteria,1QB3J@1224|Proteobacteria,1T6ME@1236|Gammaproteobacteria,1X7S1@135614|Xanthomonadales	135614|Xanthomonadales	S	Invasion gene expression up-regulator, SirB	-	-	-	-	-	-	-	-	-	-	-	-	SirB
HFD2_k127_8348442_15	1123504.JQKD01000060_gene2927	8.517e-85	286.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,4AENF@80864|Comamonadaceae	28216|Betaproteobacteria	T	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD2_k127_8348442_20	272943.RSP_4029	4.587e-51	194.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria	1224|Proteobacteria	G	Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)	-	-	2.7.1.184,2.7.1.3	ko:K00846,ko:K18478	ko00051,ko01100,ko01120,map00051,map01100,map01120	-	R00866,R03819,R10970	RC00002,RC00017,RC00608	ko00000,ko00001,ko01000,ko04147	-	-	-	PfkB,Rieske
HFD2_k127_8348442_5	1265502.KB905954_gene442	1.993e-172	544.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,4AC80@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD2_k127_8348442_16	983917.RGE_34000	1.048e-84	286.0	COG2816@1|root,COG2816@2|Bacteria,1REUJ@1224|Proteobacteria,2VRF4@28216|Betaproteobacteria,1KKP4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Nudix N-terminal	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,Nudix_N_2
HFD2_k127_8348442_24	232721.Ajs_2898	3.524e-31	123.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,4AEUE@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	sirA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HFD2_k127_8348442_6	983917.RGE_33980	4.917e-172	541.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,1KJ5H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD2_k127_8348442_12	395495.Lcho_3627	3.56e-97	328.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,2VK9F@28216|Betaproteobacteria,1KJYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD2_k127_8348442_0	983917.RGE_33960	0.0	1518.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1KJN2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HFD2_k127_8348442_11	987059.RBXJA2T_09302	2.945e-101	348.0	COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,2VKBJ@28216|Betaproteobacteria,1KN7U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	PDZ,PDZ_2,Peptidase_S41
HFD2_k127_8348442_17	987059.RBXJA2T_04328	1.305e-83	284.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,1KK5T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	ompR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_8348442_19	983917.RGE_18290	1.078e-56	216.0	COG1653@1|root,COG1653@2|Bacteria,1R5TB@1224|Proteobacteria,2VXNU@28216|Betaproteobacteria,1KN77@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HFD2_k127_8348442_8	983917.RGE_19120	2.716e-137	470.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,W_rich_C
HFD2_k127_8348442_21	983917.RGE_19120	1.785e-47	197.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,W_rich_C
HFD2_k127_8348442_3	864051.BurJ1DRAFT_1719	2.709e-180	566.0	COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,2VJMM@28216|Betaproteobacteria,1KIUP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaC	-	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
HFD2_k127_8348442_2	420662.Mpe_A1763	7.921e-196	628.0	COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2VI2I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Major facilitator Superfamily	hsrA	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
HFD2_k127_8348442_10	395495.Lcho_2766	5.302e-108	388.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2VH3I@28216|Betaproteobacteria,1KJ59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HFD2_k127_8348442_1	864051.BurJ1DRAFT_1721	0.0	1253.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1KJ39@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD2_k127_8348442_22	1276756.AUEX01000001_gene879	2.998e-46	179.0	COG3713@1|root,COG3713@2|Bacteria,1PUKH@1224|Proteobacteria,2WAUU@28216|Betaproteobacteria,4AHGK@80864|Comamonadaceae	28216|Betaproteobacteria	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
HFD2_k127_8348442_13	887062.HGR_04358	1.671e-91	306.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,4AJRM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_8348442_14	887062.HGR_04363	7.809e-87	306.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,4A9VC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_8348442_18	1276756.AUEX01000001_gene958	1.036e-69	245.0	COG3394@1|root,COG3394@2|Bacteria,1MX3P@1224|Proteobacteria,2VSK0@28216|Betaproteobacteria,4AF6E@80864|Comamonadaceae	28216|Betaproteobacteria	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HFD2_k127_8348442_7	596154.Alide2_3510	9.556e-145	480.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,4ACZ5@80864|Comamonadaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD2_k127_8348442_9	1276756.AUEX01000001_gene961	1.824e-132	431.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,4AB91@80864|Comamonadaceae	28216|Betaproteobacteria	M	glycosyl transferase family 2	gtrB	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HFD2_k127_8348442_4	795666.MW7_3257	2.022e-177	565.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2VK6I@28216|Betaproteobacteria,1JZZH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD2_k127_8348442_25	864051.BurJ1DRAFT_2414	7.569e-18	83.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8355983_0	543728.Vapar_0219	1.036e-234	729.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,4AB9B@80864|Comamonadaceae	28216|Betaproteobacteria	P	ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD2_k127_8355983_2	420662.Mpe_A3509	2.402e-48	180.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2W2SU@28216|Betaproteobacteria,1KNNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD2_k127_8355983_1	420662.Mpe_A0173	7.191e-167	526.0	COG0189@1|root,COG0189@2|Bacteria,1QVU3@1224|Proteobacteria,2WH5E@28216|Betaproteobacteria,1KIV9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	HJ	Glutamate-cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
HFD2_k127_8362262_3	296591.Bpro_2754	2.618e-83	280.0	COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,2VNZS@28216|Betaproteobacteria,4ABT8@80864|Comamonadaceae	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD2_k127_8362262_0	398578.Daci_3052	3.47e-222	694.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,4ADCR@80864|Comamonadaceae	28216|Betaproteobacteria	E	Aminotransferase class-V	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD2_k127_8362262_1	595537.Varpa_3161	1.543e-162	538.0	COG3181@1|root,COG3181@2|Bacteria,1PZK3@1224|Proteobacteria,2VJ65@28216|Betaproteobacteria,4ABJ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_8362262_2	395495.Lcho_3441	7.274e-160	507.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,1KKCG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	AMP-binding enzyme	paaK_2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HFD2_k127_8362513_3	420662.Mpe_A1171	5.185e-68	231.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,1KKF1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	fdhB	-	-	ko:K00124,ko:K07307	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R09501	RC02555,RC02796	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_7
HFD2_k127_8362513_5	395495.Lcho_3726	3.455e-10	64.0	2EIHA@1|root,33C8N@2|Bacteria,1NG9G@1224|Proteobacteria,2VXQQ@28216|Betaproteobacteria,1KMQY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8362513_1	420662.Mpe_A1173	4.047e-160	513.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1KJRA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Formate dehydrogenase gamma subunit	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HFD2_k127_8362513_4	1532557.JL37_19290	2.085e-29	124.0	2CKKR@1|root,332MC@2|Bacteria,1NCAT@1224|Proteobacteria,2VW6M@28216|Betaproteobacteria,3T7T1@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8362513_2	395495.Lcho_3723	4.414e-144	468.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,1KJG6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HFD2_k127_8362513_0	1286631.X805_12150	1.76e-175	560.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,1KJY6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	molybdopterin	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD2_k127_8362513_6	395495.Lcho_1813	1.202e-09	65.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2VNEC@28216|Betaproteobacteria,1KK9T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	3.6.3.55	ko:K05773,ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HFD2_k127_8376811_5	1265502.KB905948_gene992	4.607e-106	346.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,4ACNQ@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_8376811_4	1265502.KB905948_gene991	3.615e-174	561.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,4ABCC@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD2_k127_8376811_2	420662.Mpe_A3116	1.277e-212	670.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,1KJUP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD2_k127_8376811_10	1265502.KB905932_gene1939	2.106e-45	176.0	COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,4AEII@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the frataxin family	cyaY	-	-	ko:K06202	-	-	-	-	ko00000	-	-	-	Frataxin_Cyay
HFD2_k127_8376811_0	420662.Mpe_A3114	0.0	1190.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1KK5W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HFD2_k127_8376811_3	983917.RGE_08170	1.854e-204	640.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,1KJ3J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HFD2_k127_8376811_7	420662.Mpe_A3112	5.669e-80	272.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,1KJKT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Fimbrial assembly	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HFD2_k127_8376811_6	987059.RBXJA2T_01075	1.143e-97	325.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,1KKGW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HFD2_k127_8376811_8	420662.Mpe_A3110	1.915e-76	260.0	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,1KKJA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	pilus assembly protein PilP	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
HFD2_k127_8376811_1	864051.BurJ1DRAFT_1150	4.4e-323	1013.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KJSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HFD2_k127_8376811_9	395495.Lcho_3401	6.282e-74	254.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,1KKVT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HFD2_k127_8376811_11	1286631.X805_18710	5.188e-07	54.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1KK3W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HFD2_k127_8400573_2	1265502.KB905953_gene748	2.776e-125	402.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,4A9Q6@80864|Comamonadaceae	28216|Betaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HFD2_k127_8400573_6	448385.sce4928	1.776e-82	290.0	COG0504@1|root,COG0504@2|Bacteria,1QBV2@1224|Proteobacteria,43A2I@68525|delta/epsilon subdivisions,2X20W@28221|Deltaproteobacteria,2YZU3@29|Myxococcales	28221|Deltaproteobacteria	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HFD2_k127_8400573_4	987059.RBXJA2T_03106	1.857e-99	339.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,1KJPK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	Glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD2_k127_8400573_1	614083.AWQR01000041_gene782	1.434e-141	458.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VIVJ@28216|Betaproteobacteria,4ABMK@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD2_k127_8400573_0	1286631.X805_17060	3.426e-173	567.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1KJ9I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD2_k127_8400573_3	1538295.JY96_12505	5.003e-118	384.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,1KJXI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HFD2_k127_8400573_5	983917.RGE_03120	5.813e-94	326.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2VS3R@28216|Betaproteobacteria,1KPID@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Uracil DNA glycosylase superfamily	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD2_k127_8400573_7	987059.RBXJA2T_03242	2.319e-19	87.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,1KJXX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD2_k127_8401329_5	701347.Entcl_2594	5.485e-10	61.0	COG4136@1|root,COG4136@2|Bacteria,1RA88@1224|Proteobacteria,1S207@1236|Gammaproteobacteria,3X49V@547|Enterobacter	1236|Gammaproteobacteria	S	ATPases associated with a variety of cellular activities	ynjD	-	-	ko:K05779	-	M00192	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HFD2_k127_8401329_3	395495.Lcho_2531	2.26e-71	247.0	COG0558@1|root,COG0558@2|Bacteria,1RD5Y@1224|Proteobacteria,2VSGP@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HFD2_k127_8401329_0	864051.BurJ1DRAFT_1553	0.0	1047.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KJUI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
HFD2_k127_8401329_4	864051.BurJ1DRAFT_1554	2.202e-69	244.0	292MF@1|root,32CTK@2|Bacteria,1RJGD@1224|Proteobacteria,2VSMH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HFD2_k127_8401329_2	864051.BurJ1DRAFT_1555	2.204e-142	460.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1KMR3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_8401329_1	1265502.KB905929_gene2226	7.587e-150	477.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,4AAMH@80864|Comamonadaceae	28216|Betaproteobacteria	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HFD2_k127_84018_5	543728.Vapar_5579	7.291e-115	376.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria	28216|Betaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_84018_2	543728.Vapar_5580	1.106e-287	902.0	COG0784@1|root,COG1414@1|root,COG4191@1|root,COG0784@2|Bacteria,COG1414@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,4ACW0@80864|Comamonadaceae	28216|Betaproteobacteria	T	ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1
HFD2_k127_84018_6	1157708.KB907462_gene924	6.27e-102	338.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,4ABIC@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator crp fnr family	fnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD2_k127_84018_7	1157708.KB907462_gene925	2.826e-22	103.0	COG0078@1|root,COG0078@2|Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.7.2.2	ko:K00611,ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00220,map00230,map00910,map01100,map01110,map01120,map01130,map01200,map01230	M00029,M00844	R00150,R01395,R01398	RC00002,RC00043,RC00096,RC02803,RC02804	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD2_k127_84018_4	395495.Lcho_3663	2.768e-221	717.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,1KKEB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD2_k127_84018_3	395495.Lcho_3661	3.555e-227	758.0	COG0369@1|root,COG1145@1|root,COG0369@2|Bacteria,COG1145@2|Bacteria,1NCKQ@1224|Proteobacteria,2VIZE@28216|Betaproteobacteria,1KKD1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidoreductase NAD-binding domain	boxA	-	1.14.13.208,1.18.1.2,1.19.1.1	ko:K00528,ko:K02641,ko:K15511	ko00195,ko00362,ko01100,map00195,map00362,map01100	-	R09555,R10159	RC01739	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,Fer4,NAD_binding_1
HFD2_k127_84018_1	864051.BurJ1DRAFT_0328	2.757e-308	945.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,1KJY5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HFD2_k127_84018_0	395495.Lcho_3659	2.19e-321	987.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria,1KK86@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD2_k127_8405351_3	864051.BurJ1DRAFT_2770	1.786e-136	439.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2W9GX@28216|Betaproteobacteria,1KNPZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD2_k127_8405351_8	535289.Dtpsy_1914	2.898e-97	332.0	2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
HFD2_k127_8405351_9	1123487.KB892841_gene4304	1.227e-76	265.0	COG2863@1|root,COG2863@2|Bacteria,1RM00@1224|Proteobacteria,2VTQZ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_8405351_2	1163617.SCD_n00335	4.333e-183	582.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8405351_0	420662.Mpe_A0874	0.0	1390.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,1KIU9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE1	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_C,Transketolase_N
HFD2_k127_8405351_5	338969.Rfer_3644	3.668e-126	416.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VMHH@28216|Betaproteobacteria,4ADY8@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
HFD2_k127_8405351_1	864051.BurJ1DRAFT_3964	1.579e-190	601.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2VKXM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD2_k127_8405351_13	296591.Bpro_1360	3.789e-53	196.0	COG1376@1|root,COG1376@2|Bacteria,1NVQI@1224|Proteobacteria,2W2SC@28216|Betaproteobacteria,4AHXR@80864|Comamonadaceae	28216|Betaproteobacteria	S	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8405351_11	314264.ROS217_05524	1.209e-65	248.0	28N3P@1|root,2ZB9B@2|Bacteria,1R92E@1224|Proteobacteria,2U4X5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8405351_10	1040989.AWZU01000016_gene2506	3.208e-73	272.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Thioesterase
HFD2_k127_8405351_4	395495.Lcho_2511	5.489e-130	419.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,1KJ0N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HFD2_k127_8405351_14	338969.Rfer_1810	3.768e-37	161.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VTS2@28216|Betaproteobacteria,4AEQM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD2_k127_8405351_12	1458275.AZ34_14275	1.368e-53	205.0	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,4AE6S@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD2_k127_8405351_7	267608.RSp1365	7.368e-103	345.0	COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,2VI6Y@28216|Betaproteobacteria,1K496@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Phosphate acyltransferases	yihG	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HFD2_k127_8405351_6	1379270.AUXF01000004_gene2919	3.105e-115	405.0	COG0515@1|root,COG0515@2|Bacteria,1ZUF3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HFD2_k127_8450220_1	595537.Varpa_0582	2.607e-66	234.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VT8A@28216|Betaproteobacteria,4AERM@80864|Comamonadaceae	28216|Betaproteobacteria	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2,SpoIIE
HFD2_k127_8450220_2	765911.Thivi_2295	1.87e-53	191.0	2ANY6@1|root,31DZ3@2|Bacteria,1RIZN@1224|Proteobacteria,1S77G@1236|Gammaproteobacteria,1X0TD@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4280)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4280
HFD2_k127_8450220_4	1002339.HMPREF9373_1005	8.177e-13	78.0	COG2885@1|root,COG2885@2|Bacteria,1RDHY@1224|Proteobacteria,1S4P2@1236|Gammaproteobacteria,3NINX@468|Moraxellaceae	1236|Gammaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HFD2_k127_8450220_0	1288494.EBAPG3_6000	4.237e-172	551.0	COG3522@1|root,COG3522@2|Bacteria,1MXKE@1224|Proteobacteria,2VKW8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	type VI secretion protein	-	-	-	ko:K11893	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VasE
HFD2_k127_8450220_3	395495.Lcho_4056	7.116e-38	147.0	COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,2VMB4@28216|Betaproteobacteria,1KK8Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	N	TIGRFAM type IV VI secretion system protein, DotU family	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DotU,OmpA
HFD2_k127_8475114_5	296591.Bpro_1187	1.153e-73	254.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2VU6P@28216|Betaproteobacteria	28216|Betaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8475114_0	338969.Rfer_3759	5.931e-231	721.0	COG0446@1|root,COG0446@2|Bacteria,1PP77@1224|Proteobacteria,2W9FF@28216|Betaproteobacteria,4AA7E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD2_k127_8475114_1	864051.BurJ1DRAFT_3306	1.642e-160	529.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,1KKAX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HFD2_k127_8475114_3	864051.BurJ1DRAFT_3307	7.152e-94	325.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
HFD2_k127_8475114_4	864051.BurJ1DRAFT_3308	1.338e-75	263.0	COG0589@1|root,COG0589@2|Bacteria,1NBKV@1224|Proteobacteria	1224|Proteobacteria	T	PFAM UspA domain protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
HFD2_k127_8475114_7	864051.BurJ1DRAFT_3309	5.585e-35	151.0	2DDIC@1|root,32U1K@2|Bacteria,1NDK2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8475114_2	864051.BurJ1DRAFT_3310	2.447e-143	467.0	COG0730@1|root,COG0730@2|Bacteria,1Q05V@1224|Proteobacteria,2VW5H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_8475114_6	864051.BurJ1DRAFT_3311	1.107e-45	168.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria,1KKQ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
HFD2_k127_8479801_0	203275.BFO_1118	1.909e-147	491.0	COG1502@1|root,COG1502@2|Bacteria,4NVWC@976|Bacteroidetes,2FZM7@200643|Bacteroidia,2318K@171551|Porphyromonadaceae	976|Bacteroidetes	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD2_k127_8479801_4	420662.Mpe_A0045	1.755e-59	233.0	COG2940@1|root,COG2940@2|Bacteria,1RIQT@1224|Proteobacteria,2VT7F@28216|Betaproteobacteria,1KM5N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD2_k127_8479801_2	1123504.JQKD01000053_gene4354	2.959e-102	342.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VIRU@28216|Betaproteobacteria,4AC6I@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Ornithine cyclodeaminase mu-crystallin	-	-	1.5.1.1,4.3.1.12	ko:K01750,ko:K19743	ko00310,ko00330,ko00960,ko01100,ko01110,ko01130,ko01230,map00310,map00330,map00960,map01100,map01110,map01130,map01230	-	R00671,R01246,R01249,R02201,R02203	RC00135,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD2_k127_8479801_3	991905.SL003B_2629	1.134e-66	235.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,4BS0C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
HFD2_k127_8479801_6	358220.C380_00600	1.153e-43	182.0	COG2823@1|root,COG2823@2|Bacteria,1RITC@1224|Proteobacteria,2VSSR@28216|Betaproteobacteria,4AEQX@80864|Comamonadaceae	28216|Betaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_8479801_1	522306.CAP2UW1_3945	7.837e-118	384.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2VMEB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Threonyl alanyl tRNA synthetase SAD	alaS_2	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HFD2_k127_8479801_7	1265502.KB905947_gene1044	5.095e-29	126.0	2EGTR@1|root,33AJW@2|Bacteria,1NN4K@1224|Proteobacteria,2VY7S@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8479801_5	1123504.JQKD01000002_gene3752	1.944e-55	208.0	2BWWN@1|root,32XHS@2|Bacteria,1N289@1224|Proteobacteria,2VU35@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD2_k127_8479801_9	1123504.JQKD01000002_gene3753	5.457e-07	61.0	COG2770@1|root,COG2770@2|Bacteria,1QZYS@1224|Proteobacteria,2VJTC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
HFD2_k127_8505197_8	864051.BurJ1DRAFT_2908	1.6e-57	201.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,1KJVG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD2_k127_8505197_0	864051.BurJ1DRAFT_2907	0.0	1120.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,1KKDN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD2_k127_8505197_4	983917.RGE_27110	2.794e-71	245.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,1KKZ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD2_k127_8505197_9	452662.SJA_C1-25470	1.778e-54	203.0	COG4188@1|root,COG4188@2|Bacteria,1R9J5@1224|Proteobacteria,2U60U@28211|Alphaproteobacteria,2K4C5@204457|Sphingomonadales	204457|Sphingomonadales	S	Platelet-activating factor acetylhydrolase plasma intracellular isoform II	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8505197_5	1265502.KB905930_gene1429	8.546e-66	237.0	COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,2VS5T@28216|Betaproteobacteria,4AJE7@80864|Comamonadaceae	28216|Betaproteobacteria	D	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8505197_7	395495.Lcho_2573	1.229e-61	236.0	2DP5N@1|root,330MP@2|Bacteria,1NEVU@1224|Proteobacteria,2VWCM@28216|Betaproteobacteria,1KMHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8505197_10	983917.RGE_27100	8.767e-46	184.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2VTY8@28216|Betaproteobacteria,1KM5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Ribosome-associated heat shock protein	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HFD2_k127_8505197_1	864051.BurJ1DRAFT_2904	2.403e-189	609.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2WHKM@28216|Betaproteobacteria,1KKH4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Two-component sensor kinase N-terminal	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HFD2_k127_8505197_3	395495.Lcho_2570	1.329e-103	341.0	COG0745@1|root,COG0745@2|Bacteria,1R4GB@1224|Proteobacteria,2VJDU@28216|Betaproteobacteria,1KKIF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07774	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_8505197_2	365044.Pnap_1234	2.165e-170	539.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,4AAYT@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HFD2_k127_8505197_6	395495.Lcho_2568	3.63e-62	218.0	2C1K4@1|root,30F52@2|Bacteria,1REDQ@1224|Proteobacteria,2VRSY@28216|Betaproteobacteria,1KM6V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HFD2_k127_8505197_11	614083.AWQR01000050_gene3490	9.202e-07	58.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AA69@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD2_k127_8551503_8	983917.RGE_06660	3.116e-24	107.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KJHT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HFD2_k127_8551503_0	983917.RGE_06650	6.686e-216	674.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KJZA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Radical SAM	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HFD2_k127_8551503_4	395495.Lcho_1447	1.47e-81	273.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria,1KKV4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	transcriptional regulator AsnC family	nirH	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HFD2_k127_8551503_5	983917.RGE_06630	7.326e-67	235.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,1KNJ1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	overlaps another CDS with the same product name	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HFD2_k127_8551503_3	395495.Lcho_1445	2.955e-130	424.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,1KN1X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	COG1522 Transcriptional regulators	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HFD2_k127_8551503_1	983917.RGE_06610	2.686e-204	647.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,1KK46@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cytochrome D1 heme domain	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
HFD2_k127_8551503_6	983917.RGE_06600	3.252e-41	154.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria,1KMDM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	nirC	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
HFD2_k127_8551503_7	987059.RBXJA2T_16142	1.842e-38	145.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1KNZU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HFD2_k127_8551503_2	864051.BurJ1DRAFT_0681	1.519e-189	592.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KJI0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HFD2_k127_8583643_6	296591.Bpro_4698	3.883e-28	113.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2WFJM@28216|Betaproteobacteria,4AD19@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_8583643_1	296591.Bpro_4700	1.486e-183	580.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,4AD0R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HFD2_k127_8583643_0	296591.Bpro_4702	1.516e-219	710.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VK5V@28216|Betaproteobacteria,4AAPR@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HFD2_k127_8583643_5	296591.Bpro_4703	6.664e-64	228.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,4AAAK@80864|Comamonadaceae	28216|Betaproteobacteria	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD2_k127_8583643_3	626418.bglu_2g03340	1.67e-99	341.0	COG1414@1|root,COG1414@2|Bacteria,1QYTM@1224|Proteobacteria,2VJV9@28216|Betaproteobacteria,1K3W5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	pcaR2	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HFD2_k127_8583643_4	420662.Mpe_A2219	5.388e-93	320.0	COG2199@1|root,COG2199@2|Bacteria,1RAB1@1224|Proteobacteria,2VQSP@28216|Betaproteobacteria,1KKKY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD2_k127_8583643_2	420662.Mpe_A2218	5.376e-100	328.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,2VM49@28216|Betaproteobacteria,1KK9Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HFD2_k127_8591677_2	420662.Mpe_A3748	1.241e-125	408.0	COG0506@1|root,COG0506@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,1KJ8X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.3.8.7,1.5.5.2	ko:K00249,ko:K00294,ko:K13821	ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051	RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HFD2_k127_8591677_5	1265502.KB905976_gene515	1.774e-79	268.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VQBV@28216|Betaproteobacteria,4ADGR@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	lrp	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD2_k127_8591677_3	420662.Mpe_A3759	5.35e-97	322.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1KJYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HFD2_k127_8591677_1	1265502.KB905976_gene513	1.218e-206	659.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,4ACKU@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM Type II secretion system protein E	pilT	-	-	ko:K02669,ko:K12203	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2,3.A.7.10.1,3.A.7.9.1	-	-	T2SSE
HFD2_k127_8591677_0	987059.RBXJA2T_05113	5.164e-221	691.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1KJHY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD2_k127_8591677_6	864051.BurJ1DRAFT_0076	7.102e-69	254.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,1KKUY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HFD2_k127_8591677_4	420662.Mpe_A3765	2.475e-96	318.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,1KIYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD2_k127_8591677_7	395495.Lcho_1639	3.779e-42	156.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,1KMAT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HFD2_k127_8612943_3	1265502.KB905959_gene262	2.149e-137	443.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,4AB7S@80864|Comamonadaceae	28216|Betaproteobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD2_k127_8612943_1	420662.Mpe_A0291	1.291e-193	629.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,1KJFJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HFD2_k127_8612943_4	1454004.AW11_03827	7.469e-71	254.0	COG4585@1|root,COG4585@2|Bacteria,1R9XM@1224|Proteobacteria,2VR1U@28216|Betaproteobacteria,1KQ97@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325
HFD2_k127_8612943_2	535289.Dtpsy_0099	4.322e-156	502.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VKC7@28216|Betaproteobacteria,4ABMY@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
HFD2_k127_8612943_0	1265502.KB905959_gene259	2.318e-257	802.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,4AAKC@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HFD2_k127_8612943_5	1286631.X805_22260	1.169e-21	94.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1KJ7T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HFD2_k127_8627758_2	864051.BurJ1DRAFT_2523	8.424e-70	243.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,1KM6W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
HFD2_k127_8627758_1	420662.Mpe_A1576	2.084e-134	431.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2VH6T@28216|Betaproteobacteria,1KKFF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	bdhA	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HFD2_k127_8627758_0	420662.Mpe_A1577	4.969e-140	449.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,1KJPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM alpha beta hydrolase fold	phaY2	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD2_k127_8627758_3	420662.Mpe_A1578	2.362e-68	239.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,1KIXB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD2_k127_8646977_10	983917.RGE_33100	4.888e-78	261.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,1KJE2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HFD2_k127_8646977_11	420662.Mpe_A1281	7.812e-45	164.0	COG0254@1|root,COG0254@2|Bacteria,1MZ4D@1224|Proteobacteria,2VU3I@28216|Betaproteobacteria,1KMAZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL31 family	rpmE2	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD2_k127_8646977_1	420662.Mpe_A1280	2.35e-206	655.0	COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,1KJCY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	arnT	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8646977_2	420662.Mpe_A1278	6.349e-203	640.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KJ2K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	TIGRFAM phosphate regulon sensor kinase PhoR	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
HFD2_k127_8646977_7	420662.Mpe_A1277	1.473e-124	405.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,1KIU0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_8646977_8	1265502.KB905935_gene3111	1.256e-122	396.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,4AB37@80864|Comamonadaceae	28216|Betaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HFD2_k127_8646977_5	987059.RBXJA2T_09722	8.71e-154	504.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,1KK41@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD2_k127_8646977_6	1265502.KB905935_gene3113	3.157e-140	469.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,4ABXP@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_8646977_4	420662.Mpe_A1273	5.57e-166	538.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,1KJ4T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD2_k127_8646977_3	1286631.X805_04290	1.702e-173	550.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,1KIUZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HFD2_k127_8646977_0	983917.RGE_33210	1.279e-221	694.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1KJ1R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD2_k127_8646977_9	864051.BurJ1DRAFT_2458	6.568e-79	268.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,1KJ9J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD2_k127_8673539_1	1286631.X805_38400	1.422e-270	838.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KJUJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD2_k127_8673539_2	420662.Mpe_A2495	3.779e-172	546.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,1KK2P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD2_k127_8673539_0	420662.Mpe_A2494	0.0	1120.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG5000@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KPF3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD2_k127_8719507_4	395495.Lcho_2710	1.966e-09	58.0	2B0SP@1|root,31T51@2|Bacteria,1RFNM@1224|Proteobacteria,2VV2A@28216|Betaproteobacteria,1KMCH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_8719507_3	340.xcc-b100_2149	1.343e-39	148.0	COG2002@1|root,COG2002@2|Bacteria,1NX4F@1224|Proteobacteria,1T6S4@1236|Gammaproteobacteria,1X81G@135614|Xanthomonadales	135614|Xanthomonadales	K	SpoVT / AbrB like domain	VL23_17280	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HFD2_k127_8719507_2	340.xcc-b100_2150	4.674e-49	183.0	COG1487@1|root,COG1487@2|Bacteria,1RJ2J@1224|Proteobacteria,1S81V@1236|Gammaproteobacteria,1X6TK@135614|Xanthomonadales	135614|Xanthomonadales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD2_k127_8719507_0	395495.Lcho_2711	0.0	1551.0	COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2VHT2@28216|Betaproteobacteria,1KJ93@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the aconitase IPM isomerase family	acnB	-	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
HFD2_k127_8719507_1	395495.Lcho_3700	2.854e-97	332.0	COG3021@1|root,COG3021@2|Bacteria,1NJVF@1224|Proteobacteria,2W177@28216|Betaproteobacteria,1KN3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD2_k127_87444_0	395495.Lcho_1918	4.883e-244	759.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,1KJ53@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
HFD2_k127_87444_4	983917.RGE_23810	3.886e-142	465.0	COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,1KJPD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA	selU	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
HFD2_k127_87444_8	1265502.KB905934_gene3206	4.286e-90	300.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,4A9QS@80864|Comamonadaceae	28216|Betaproteobacteria	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
HFD2_k127_87444_1	864051.BurJ1DRAFT_3089	6.178e-201	635.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,1KJSJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Peptidase M48	htpX_2	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HFD2_k127_87444_5	1265502.KB905934_gene3209	2.885e-122	424.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,4AC0J@80864|Comamonadaceae	28216|Betaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HFD2_k127_87444_3	987059.RBXJA2T_05458	3.881e-154	508.0	COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,1KJDN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HFD2_k127_87444_9	864051.BurJ1DRAFT_3092	1.486e-87	296.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2VREV@28216|Betaproteobacteria,1KKNK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD2_k127_87444_13	420662.Mpe_A1107	1.939e-61	215.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,1KKS7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HFD2_k127_87444_6	1265502.KB905934_gene3217	2.142e-114	374.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,4ABE9@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD2_k127_87444_12	1265502.KB905934_gene3218	8.896e-71	252.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,4ADPE@80864|Comamonadaceae	28216|Betaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HFD2_k127_87444_16	864051.BurJ1DRAFT_3096	5.553e-37	142.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria,1KM8E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD2_k127_87444_10	395495.Lcho_0680	1.731e-74	254.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2VQM1@28216|Betaproteobacteria,1KKW5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HFD2_k127_87444_14	420662.Mpe_A1102	5.584e-59	207.0	COG2314@1|root,COG2314@2|Bacteria,1RD84@1224|Proteobacteria,2VSV6@28216|Betaproteobacteria,1KM5W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HFD2_k127_87444_2	864051.BurJ1DRAFT_3098	1.939e-184	580.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1KJVK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD2_k127_87444_7	420662.Mpe_A3016	3.785e-105	345.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1KK30@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD2_k127_87444_11	1095769.CAHF01000013_gene3343	6.678e-71	246.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,473B3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
HFD2_k127_87444_18	1144319.PMI16_03099	0.0002758	45.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2VSWS@28216|Betaproteobacteria,474CQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HFD2_k127_87444_15	420662.Mpe_A3019	1.391e-57	204.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,1KMF0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HFD2_k127_87444_17	420662.Mpe_A3020	5.708e-10	62.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,1KJCB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HFD2_k127_893043_10	543728.Vapar_2991	2.006e-17	87.0	2DQ9K@1|root,335GG@2|Bacteria,1NAA4@1224|Proteobacteria,2VW5N@28216|Betaproteobacteria,4AFQ9@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM pentapeptide MXKDX repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_893043_5	543728.Vapar_2988	9.772e-129	416.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria,4ACQB@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HFD2_k127_893043_1	1157708.KB907450_gene6089	5.154e-205	661.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,2VHKW@28216|Betaproteobacteria,4ACF9@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD2_k127_893043_9	136993.KB900627_gene447	2.352e-70	254.0	COG2706@1|root,COG2706@2|Bacteria,1NG69@1224|Proteobacteria	1224|Proteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD2_k127_893043_7	1215092.PA6_061_00060	4.095e-80	273.0	COG1309@1|root,COG1309@2|Bacteria,1NCEF@1224|Proteobacteria,1RQ8N@1236|Gammaproteobacteria,1YH55@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HFD2_k127_893043_6	78245.Xaut_2977	9.312e-103	341.0	COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,2U58G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD2_k127_893043_4	1354722.JQLS01000001_gene4807	8.089e-134	432.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,2TVRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
HFD2_k127_893043_2	1354722.JQLS01000001_gene4808	4.459e-164	529.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	MA20_06335	-	4.2.1.156,4.2.1.42,5.1.2.2	ko:K01781,ko:K20023	ko00053,ko00627,ko01120,map00053,map00627,map01120	-	R03791,R04161,R05608	RC00543,RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD2_k127_893043_3	395495.Lcho_1925	3.388e-159	507.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,1KK05@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
HFD2_k127_893043_8	864051.BurJ1DRAFT_3433	6.136e-75	256.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,1KK05@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
HFD2_k127_893043_0	640511.BC1002_5570	2.848e-242	784.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
HFD2_k127_8947_3	358220.C380_10485	3.858e-90	315.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2VMHA@28216|Betaproteobacteria,4ACPB@80864|Comamonadaceae	28216|Betaproteobacteria	G	Periplasmic binding protein domain	xylF	-	-	ko:K10543,ko:K10546	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	Peripla_BP_4
HFD2_k127_8947_1	543728.Vapar_1041	5.067e-115	376.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2VJQ7@28216|Betaproteobacteria,4AA03@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.175	ko:K22185	ko00040,map00040	-	R01429	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD2_k127_8947_0	543728.Vapar_1044	1.49e-168	535.0	COG1879@1|root,COG1879@2|Bacteria,1MXJS@1224|Proteobacteria,2VJJZ@28216|Betaproteobacteria,4ACNX@80864|Comamonadaceae	28216|Betaproteobacteria	G	Periplasmic binding protein LacI transcriptional regulator	ytfQ	-	-	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HFD2_k127_8947_2	1500894.JQNN01000001_gene111	1.702e-94	315.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,473SM@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HFD2_k127_900261_5	420662.Mpe_A0106	1.403e-137	445.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria	1224|Proteobacteria	S	Von willebrand factor, type a	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD2_k127_900261_10	420662.Mpe_A0107	2.352e-22	102.0	2EFG1@1|root,3398R@2|Bacteria,1N86X@1224|Proteobacteria,2VX76@28216|Betaproteobacteria,1KMUI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_900261_0	983917.RGE_46360	1.539e-315	975.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,1KJAS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HFD2_k127_900261_8	864051.BurJ1DRAFT_4924	5.211e-72	248.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,1KKNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD2_k127_900261_3	614083.AWQR01000033_gene2871	5.573e-204	676.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,4AA9F@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
HFD2_k127_900261_6	697282.Mettu_1702	8.981e-137	447.0	COG2182@1|root,COG2182@2|Bacteria,1QZDD@1224|Proteobacteria,1T542@1236|Gammaproteobacteria	1224|Proteobacteria	G	overlaps another CDS with the same product name	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_900261_1	697282.Mettu_1703	6.065e-314	983.0	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1MXVP@1224|Proteobacteria,1RS4C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Receptor	suxA	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD2_k127_900261_7	1095769.CAHF01000010_gene1095	5.463e-75	258.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VRAJ@28216|Betaproteobacteria,474PJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Putative FMN-binding domain	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
HFD2_k127_900261_9	395495.Lcho_0026	1.299e-62	218.0	COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,2WFNG@28216|Betaproteobacteria,1KM7D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD2_k127_900261_2	395495.Lcho_0025	1.367e-208	659.0	COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VHEY@28216|Betaproteobacteria,1KKNQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HFD2_k127_900261_4	358220.C380_02750	1.019e-193	620.0	COG2770@1|root,COG5001@1|root,COG2770@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,4AAUI@80864|Comamonadaceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,dCache_3
HFD2_k127_923343_1	296591.Bpro_4698	5.317e-240	745.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2WFJM@28216|Betaproteobacteria,4AD19@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HFD2_k127_923343_2	296591.Bpro_4697	5.641e-182	576.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VKXZ@28216|Betaproteobacteria,4A9K4@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily	phnW	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
HFD2_k127_923343_0	296591.Bpro_4696	8.92e-265	826.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD2_k127_934149_3	76114.ebA4980	5.656e-63	239.0	COG5403@1|root,COG5403@2|Bacteria,1N0H4@1224|Proteobacteria,2W217@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HFD2_k127_934149_2	1121028.ARQE01000003_gene838	7.792e-98	334.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2TR6B@28211|Alphaproteobacteria,2PIWX@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD2_k127_934149_1	1411123.JQNH01000001_gene922	5.064e-159	512.0	COG1638@1|root,COG1638@2|Bacteria,1MXUZ@1224|Proteobacteria,2TTTA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_17110	-	-	-	-	-	-	-	-	-	-	-	DctP
HFD2_k127_934149_4	1411123.JQNH01000001_gene923	5.284e-52	190.0	COG3090@1|root,COG3090@2|Bacteria,1QXYB@1224|Proteobacteria,2TTWD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HFD2_k127_934149_0	1411123.JQNH01000001_gene924	2.183e-208	664.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD2_k127_934149_5	257310.BB2452	2.367e-13	70.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5RY@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD4	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD2_k127_935278_2	1000565.METUNv1_00482	6.73e-192	602.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2VJE2@28216|Betaproteobacteria,2KV9U@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HFD2_k127_935278_0	420662.Mpe_A3777	3.089e-295	930.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,1KJEV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SpoVR like protein	spoVR2	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HFD2_k127_935278_1	1265502.KB905947_gene1081	4.41e-238	743.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,4AAZB@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	dld	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD2_k127_935278_4	395495.Lcho_0942	1.299e-89	308.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,1KJ9Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cobalamin adenosyltransferase	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HFD2_k127_935278_3	864051.BurJ1DRAFT_0070	6.145e-103	336.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,1KJN3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HFD2_k127_942921_12	420662.Mpe_A0699	4.596e-10	73.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,1KJIV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HFD2_k127_942921_3	987059.RBXJA2T_04283	1.086e-222	702.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,1KJBC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HFD2_k127_942921_2	1286631.X805_11150	1.417e-253	785.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,1KKDM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Urea ABC transporter, urea binding protein	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
HFD2_k127_942921_6	395495.Lcho_0038	4.084e-140	452.0	COG3181@1|root,COG3181@2|Bacteria,1MVQR@1224|Proteobacteria,2VM4Q@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD2_k127_942921_4	395495.Lcho_0037	1.335e-202	653.0	COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2VJB6@28216|Betaproteobacteria,1KK5Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD2_k127_942921_5	395495.Lcho_0036	9.624e-148	482.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VI9E@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD2_k127_942921_8	1265502.KB905946_gene1158	1.15e-96	335.0	COG0583@1|root,COG0583@2|Bacteria,1N3XX@1224|Proteobacteria,2VN21@28216|Betaproteobacteria,4AB5Y@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD2_k127_942921_9	196490.AUEZ01000112_gene62	1.275e-81	286.0	COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,2TVDN@28211|Alphaproteobacteria,3JS6E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD2_k127_942921_7	420662.Mpe_A0671	4.112e-137	443.0	COG2199@1|root,COG2771@1|root,COG2771@2|Bacteria,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,2WH3C@28216|Betaproteobacteria,1KPD5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_942921_0	1265502.KB905932_gene1808	0.0	1499.0	COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria,4ACV5@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_942921_11	543728.Vapar_4240	1.299e-44	186.0	COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,2VSES@28216|Betaproteobacteria,4AEBQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_gamma
HFD2_k127_942921_10	595537.Varpa_4857	1.359e-45	175.0	COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,2VSGJ@28216|Betaproteobacteria,4AEC1@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the urease beta subunit family	ureB	-	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta
HFD2_k127_942921_1	420662.Mpe_A0667	0.0	1016.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,1KK4I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HFD2_k127_949512_3	420662.Mpe_A2129	1.898e-175	555.0	COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,1KK93@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K11711	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
HFD2_k127_949512_6	420662.Mpe_A2130	8.854e-117	396.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,1KIT8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Regulator	fixJ	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD2_k127_949512_5	1265502.KB905931_gene1725	1.702e-141	454.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,4AAPJ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD2_k127_949512_0	1265502.KB905931_gene1724	0.0	1053.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,4AAI1@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HFD2_k127_949512_8	983917.RGE_23600	6.226e-47	177.0	COG0695@1|root,COG0695@2|Bacteria,1N7X3@1224|Proteobacteria,2VVPB@28216|Betaproteobacteria,1KMDR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,Glutaredoxin
HFD2_k127_949512_4	420662.Mpe_A1515	7.449e-143	465.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria,1KKFE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD2_k127_949512_2	420662.Mpe_A1514	2.516e-186	594.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,1KK8Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD2_k127_949512_7	395495.Lcho_1987	1.26e-74	254.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,1KKYN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	2Fe-2S -binding domain	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD2_k127_949512_1	864051.BurJ1DRAFT_2220	4.26e-240	750.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KJ3Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD2_k127_953079_10	1265502.KB905954_gene421	6.176e-69	237.0	2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,4ADZM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1841)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1841
HFD2_k127_953079_5	420662.Mpe_A1099	1.322e-107	357.0	COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2VIZS@28216|Betaproteobacteria,1KKHP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD2_k127_953079_0	864051.BurJ1DRAFT_4872	1.134e-246	799.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1KJ0K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HFD2_k127_953079_8	395495.Lcho_1297	1.342e-82	282.0	COG2249@1|root,COG2249@2|Bacteria,1MXFT@1224|Proteobacteria,2VMX3@28216|Betaproteobacteria,1KPAW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavodoxin-like fold	kefF	-	1.6.5.2	ko:K00355,ko:K11746,ko:K11748	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000,ko02000	2.A.37.1.1,2.A.37.1.2	-	-	Flavodoxin_2
HFD2_k127_953079_7	1265502.KB905954_gene424	9.52e-95	314.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,4ABG3@80864|Comamonadaceae	28216|Betaproteobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HFD2_k127_953079_9	1265502.KB905954_gene425	1.294e-69	249.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,4ADKH@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD2_k127_953079_1	1454004.AW11_01108	6.263e-191	606.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,2VN1P@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
HFD2_k127_953079_3	1454004.AW11_01107	5.647e-134	432.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria	28216|Betaproteobacteria	P	transport	-	-	-	ko:K02025,ko:K10237,ko:K17245	ko02010,map02010	M00204,M00207,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17,3.A.1.1.40	-	-	BPD_transp_1
HFD2_k127_953079_4	1454004.AW11_01106	1.198e-109	377.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10238	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HFD2_k127_953079_2	1454004.AW11_01105	1.154e-147	490.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	malK	-	-	ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD2_k127_953079_6	420662.Mpe_A1151	2.706e-96	324.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,1KJ2T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	epsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD2_k127_953079_11	1265502.KB905954_gene428	1.766e-60	229.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,4ADJN@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD2_k127_99678_4	987059.RBXJA2T_08725	9.062e-118	393.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,1KIZ6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD2_k127_99678_5	1095769.CAHF01000008_gene3610	1.203e-117	410.0	COG0438@1|root,COG1232@1|root,COG0438@2|Bacteria,COG1232@2|Bacteria,1QU2N@1224|Proteobacteria,2VJ9J@28216|Betaproteobacteria,476WG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,Glyco_trans_1_4,NAD_binding_8
HFD2_k127_99678_1	1254432.SCE1572_20185	3.035e-133	442.0	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HFD2_k127_99678_0	983917.RGE_25170	2.479e-182	582.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VMW6@28216|Betaproteobacteria,1KNAG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN2	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD2_k127_99678_11	1157708.KB907455_gene3431	1.464e-06	61.0	2DDAZ@1|root,2ZHD1@2|Bacteria,1P5XM@1224|Proteobacteria,2W5MR@28216|Betaproteobacteria,4AIW5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD2_k127_99678_7	983917.RGE_25060	4.777e-38	159.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Lipocalin family protein	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HFD2_k127_99678_10	987059.RBXJA2T_08705	5.924e-07	61.0	2FJC4@1|root,34B20@2|Bacteria,1P1U3@1224|Proteobacteria	1224|Proteobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD2_k127_99678_2	748247.AZKH_4533	1.548e-130	449.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2VJ6I@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM AsmA family protein	asmA	-	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA
HFD2_k127_99678_6	983917.RGE_28520	9.191e-43	162.0	COG3871@1|root,COG3871@2|Bacteria,1RF7K@1224|Proteobacteria,2VSCF@28216|Betaproteobacteria,1KNZS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
HFD2_k127_99678_8	1458275.AZ34_05150	2.311e-33	143.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,2VUHT@28216|Betaproteobacteria,4AF5X@80864|Comamonadaceae	28216|Betaproteobacteria	S	SMART Transport-associated and nodulation region	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HFD2_k127_99678_3	1218076.BAYB01000018_gene3365	3.265e-129	440.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1K3XS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
## 3941 queries scanned
## Total time (seconds): 204.34398007392883
## Rate: 19.29 q/s