## Wed Nov 13 04:50:39 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD3_bin.13.fa -m mmseqs --itype genome -o HFD3_bin.13 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD3_bin.13 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD3_k127_1011659_8	795666.MW7_2399	1.974e-08	58.0	COG2885@1|root,COG2885@2|Bacteria,1QUVV@1224|Proteobacteria,2WH8W@28216|Betaproteobacteria,1KG6M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HFD3_k127_1011659_3	760568.Desku_0629	1.316e-77	277.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,260E4@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_1011659_6	1210908.HSB1_04450	7.059e-49	191.0	COG0477@1|root,arCOG00130@2157|Archaea,2XV7S@28890|Euryarchaeota,23U27@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1011659_1	314230.DSM3645_08352	1.202e-99	341.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2IWZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3,ABC_tran
HFD3_k127_1011659_0	344747.PM8797T_13690	2.415e-109	362.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2IWZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3,ABC_tran
HFD3_k127_1011659_4	1267534.KB906755_gene4491	1.812e-73	261.0	COG1566@1|root,COG1566@2|Bacteria,3Y53G@57723|Acidobacteria	57723|Acidobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD3_k127_1011659_5	706587.Desti_2416	3.39e-73	256.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2WKKK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	dmeF	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HFD3_k127_1011659_2	1297742.A176_06617	1.705e-89	309.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM MltA domain protein	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HFD3_k127_1011659_7	1128421.JAGA01000002_gene1695	5.1e-15	78.0	COG3824@1|root,COG3824@2|Bacteria,2NPZF@2323|unclassified Bacteria	2|Bacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,Zincin_1
HFD3_k127_1042230_8	1280689.AUJC01000007_gene3267	5.991e-11	66.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,36F6D@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	ssuC_2	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1042230_1	298653.Franean1_4523	1.081e-74	261.0	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_1042230_6	179408.Osc7112_1594	7.216e-21	100.0	COG3665@1|root,COG3665@2|Bacteria,1G0FK@1117|Cyanobacteria,1H9VE@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
HFD3_k127_1042230_7	1944.JOAZ01000033_gene146	1.47e-17	94.0	COG0715@1|root,COG0715@2|Bacteria,2HFTU@201174|Actinobacteria,41CZK@629295|Streptomyces griseus group	2|Bacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1042230_2	1123023.JIAI01000003_gene2637	8.276e-54	198.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1042230_4	639283.Snov_4142	5.529e-25	116.0	COG0715@1|root,COG0715@2|Bacteria,1R4AB@1224|Proteobacteria,2U2A0@28211|Alphaproteobacteria,3F150@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1042230_3	1123023.JIAI01000003_gene2635	4.638e-48	184.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1042230_0	67275.JOAP01000049_gene797	1.639e-92	310.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
HFD3_k127_1042230_5	621372.ACIH01000024_gene4257	8.84e-25	108.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,26TE8@186822|Paenibacillaceae	91061|Bacilli	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612,ko:K16874	ko00365,ko00627,ko01120,ko01220,map00365,map00627,map01120,map01220	-	R01238,R10213	RC00391,RC03086	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_104555_0	351607.Acel_0894	5.93e-106	356.0	COG5276@1|root,COG5276@2|Bacteria,2IH2N@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD3_k127_104555_1	1173263.Syn7502_03004	4.901e-43	170.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_104555_2	743719.PaelaDRAFT_0962	8.274e-17	92.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_105175_2	443152.MDG893_15467	3.758e-61	226.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_105175_1	933262.AXAM01000036_gene2178	1.838e-82	290.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,43B26@68525|delta/epsilon subdivisions,2X6G6@28221|Deltaproteobacteria,2MKC2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_105175_7	266265.Bxe_A2048	4.874e-38	146.0	COG0346@1|root,COG0346@2|Bacteria,1PK3B@1224|Proteobacteria,2W8DQ@28216|Betaproteobacteria,1K798@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_105175_0	221288.JH992901_gene3895	5.835e-133	434.0	COG0715@1|root,COG0715@2|Bacteria,1GFIM@1117|Cyanobacteria	1117|Cyanobacteria	P	Protein of unknown function (DUF3500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3500
HFD3_k127_105175_10	1231391.AMZF01000014_gene2432	3.888e-11	74.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_105175_3	1123060.JONP01000001_gene1641	1.108e-59	216.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria,2JUQX@204441|Rhodospirillales	204441|Rhodospirillales	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD3_k127_105175_11	653045.Strvi_5301	3.906e-10	71.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_105175_4	463191.SSEG_09285	2.651e-59	221.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_105175_9	935836.JAEL01000097_gene3442	9.162e-13	79.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,1ZC0Z@1386|Bacillus	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	ytlA	GO:0003674,GO:0005215	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_105175_6	1037409.BJ6T_87360	1.121e-44	176.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_105175_5	189753.AXAS01000075_gene6004	1.535e-47	183.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_105175_8	189753.AXAS01000011_gene7551	1.723e-23	111.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2URQN@28211|Alphaproteobacteria,3K6JB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
HFD3_k127_1056990_6	1463825.JNXC01000001_gene6151	0.0001669	51.0	COG0697@1|root,COG0697@2|Bacteria,2GMPU@201174|Actinobacteria,4E35E@85010|Pseudonocardiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_1056990_3	671143.DAMO_1223	9.574e-57	202.0	COG2193@1|root,COG2193@2|Bacteria,2NR6S@2323|unclassified Bacteria	2|Bacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD3_k127_1056990_5	1150626.PHAMO_230027	1.148e-05	53.0	2E7EC@1|root,331XC@2|Bacteria,1N9UI@1224|Proteobacteria,2UJ3Q@28211|Alphaproteobacteria,2JU4M@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1056990_2	521000.PROVRETT_08368	7.072e-59	219.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,3Z8NY@586|Providencia	1236|Gammaproteobacteria	EGP	Psort location CytoplasmicMembrane, score 10.00	yajR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_1056990_0	330214.NIDE3131	4.947e-100	336.0	COG0668@1|root,COG0668@2|Bacteria,3J0YK@40117|Nitrospirae	40117|Nitrospirae	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
HFD3_k127_1056990_1	439235.Dalk_4026	2.618e-92	313.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42YUK@68525|delta/epsilon subdivisions,2WTYA@28221|Deltaproteobacteria,2MMJC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HFD3_k127_1056990_4	443152.MDG893_15260	1.178e-42	168.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1066604_11	264732.Moth_0731	4.21e-48	180.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24AHX@186801|Clostridia,42FZR@68295|Thermoanaerobacterales	186801|Clostridia	S	Zn-dependent hydrolases of the	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_1066604_2	671143.DAMO_2098	5.777e-131	426.0	COG0604@1|root,COG0604@2|Bacteria,2NQR7@2323|unclassified Bacteria	2|Bacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_1066604_19	671143.DAMO_2368	5.154e-18	92.0	COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria	2|Bacteria	NPTU	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HFD3_k127_1066604_5	575540.Isop_3073	1.306e-92	312.0	COG1834@1|root,COG1834@2|Bacteria,2IXSX@203682|Planctomycetes	203682|Planctomycetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HFD3_k127_1066604_1	344747.PM8797T_00277	1.905e-140	458.0	COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HFD3_k127_1066604_15	644282.Deba_0317	5.893e-38	153.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HFD3_k127_1066604_18	861299.J421_2404	4.804e-20	96.0	2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1066604_4	880073.Calab_1201	5.102e-94	324.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_1066604_22	396588.Tgr7_3066	1.22e-06	57.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	DnaK suppressor protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD3_k127_1066604_26	861299.J421_3379	0.0001969	49.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
HFD3_k127_1066604_25	700598.Niako_1649	9.527e-05	48.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	1.14.99.57	ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
HFD3_k127_1066604_21	702113.PP1Y_Mpl2143	1.138e-07	59.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria,2K7EE@204457|Sphingomonadales	204457|Sphingomonadales	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD3_k127_1066604_10	443152.MDG893_15295	1.165e-49	191.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1066604_17	1121405.dsmv_0235	6.956e-31	132.0	COG1102@1|root,COG1102@2|Bacteria,1R1X4@1224|Proteobacteria,43DC5@68525|delta/epsilon subdivisions,2X8I5@28221|Deltaproteobacteria,2MPI3@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HFD3_k127_1066604_14	935836.JAEL01000110_gene705	5.419e-40	164.0	COG0477@1|root,COG2814@2|Bacteria,1UIZZ@1239|Firmicutes,4ISYZ@91061|Bacilli,1ZSFR@1386|Bacillus	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1066604_3	1168034.FH5T_10880	4.709e-113	383.0	COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia	976|Bacteroidetes	H	acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_1066604_9	1121106.JQKB01000001_gene3233	4.494e-64	228.0	COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2TV48@28211|Alphaproteobacteria,2JREV@204441|Rhodospirillales	204441|Rhodospirillales	H	Domain of unknown function DUF108	-	-	-	-	-	-	-	-	-	-	-	-	DUF108,NAD_binding_3
HFD3_k127_1066604_13	886293.Sinac_6891	4.078e-40	156.0	COG1999@1|root,COG2322@1|root,COG1999@2|Bacteria,COG2322@2|Bacteria,2IZH2@203682|Planctomycetes	203682|Planctomycetes	S	SCO1/SenC	-	-	-	ko:K07152,ko:K08976	-	-	-	-	ko00000,ko03029	-	-	-	DUF420,SCO1-SenC
HFD3_k127_1066604_12	1201288.M900_0274	6.15e-47	178.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,42RCU@68525|delta/epsilon subdivisions,2MT7P@213481|Bdellovibrionales,2WMXY@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Cytochrome c oxidase, subunit III	coxC	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
HFD3_k127_1066604_16	864702.OsccyDRAFT_1550	2.079e-33	137.0	COG1845@1|root,COG1845@2|Bacteria,1G02A@1117|Cyanobacteria,1H849@1150|Oscillatoriales	1117|Cyanobacteria	C	Heme copper-type cytochrome quinol oxidase subunit 3	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD3_k127_1066604_6	671143.DAMO_1659	3.061e-87	301.0	COG0109@1|root,COG0109@2|Bacteria,2NPBW@2323|unclassified Bacteria	2|Bacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	iJN746.PP_0110,iSB619.SA_RS05465,iSFxv_1172.SFxv_0410,iYO844.BSU12080	UbiA
HFD3_k127_1066604_7	671143.DAMO_1660	3.496e-81	284.0	COG1612@1|root,COG1612@2|Bacteria,2NQ3D@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome oxidase assembly protein	ctaA	-	-	ko:K02259,ko:K03110	ko00190,ko00860,ko01100,ko01110,ko02020,ko02024,ko03060,ko03070,ko04714,map00190,map00860,map01100,map01110,map02020,map02024,map03060,map03070,map04714	M00154,M00335	R07412	RC00769	ko00000,ko00001,ko00002,ko02044,ko03029	3.A.5.1,3.A.5.2,3.A.5.7,3.D.4.4	-	-	COX15-CtaA
HFD3_k127_1066604_0	671143.DAMO_1165	3.736e-208	662.0	COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD3_k127_1066604_8	671143.DAMO_1166	3.006e-78	267.0	COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HFD3_k127_1066604_27	67352.JODS01000003_gene1800	0.0003634	47.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD,FixH
HFD3_k127_1091227_4	269799.Gmet_0860	4.31e-05	55.0	COG3170@1|root,COG3170@2|Bacteria,1NJU0@1224|Proteobacteria,42X5D@68525|delta/epsilon subdivisions,2WSUG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1091227_1	710686.Mycsm_01832	1.074e-47	186.0	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD3_k127_1091227_0	1217718.ALOU01000009_gene1072	3.672e-113	385.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN32@28216|Betaproteobacteria	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_1091227_2	1160137.KB907308_gene6991	1.547e-36	144.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4G4IQ@85025|Nocardiaceae	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
HFD3_k127_1099455_14	237368.SCABRO_03797	9.501e-09	66.0	293PF@1|root,2ZR54@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1099455_17	195250.CM001776_gene190	0.0001541	48.0	2C7M6@1|root,32U5X@2|Bacteria,1G7T2@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1099455_8	32057.KB217478_gene6685	3.335e-39	148.0	arCOG07672@1|root,32Z5Y@2|Bacteria,1G846@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF4258)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
HFD3_k127_1099455_11	1173028.ANKO01000171_gene3849	4.045e-26	108.0	2EF9F@1|root,3392C@2|Bacteria,1GRBP@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1099455_3	929558.SMGD1_1196	2.003e-79	294.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42UA0@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,PD40,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
HFD3_k127_1099455_15	1499967.BAYZ01000182_gene4433	5.787e-07	63.0	297CM@1|root,2ZUK5@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384
HFD3_k127_1099455_6	1121396.KB893001_gene3950	1.735e-44	183.0	COG4995@1|root,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,42XEE@68525|delta/epsilon subdivisions,2WT63@28221|Deltaproteobacteria,2MP6A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,LCAT
HFD3_k127_1099455_10	1156935.QWE_02130	9.907e-28	120.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria,4B8XD@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Lysophospholipase L1 and related esterases	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HFD3_k127_1099455_9	937777.Deipe_0616	4.012e-31	136.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.4,4.1.3.1	ko:K01179,ko:K01637	ko00500,ko00630,ko01100,ko01110,ko01120,ko01200,map00500,map00630,map01100,map01110,map01120,map01200	M00012	R00479,R06200,R11307,R11308	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	GH5,GH9	-	Kelch_1,Laminin_G_3,Malectin,PKD,TIG
HFD3_k127_1099455_12	237368.SCABRO_03646	8.4e-26	114.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_1099455_7	1089553.Tph_c01100	1.897e-41	156.0	COG2402@1|root,COG2402@2|Bacteria,1V8M3@1239|Firmicutes,24MAG@186801|Clostridia,42II4@68295|Thermoanaerobacterales	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD3_k127_1099455_18	1210884.HG799462_gene8494	0.0007204	44.0	COG1595@1|root,COG1595@2|Bacteria,2IZNR@203682|Planctomycetes	203682|Planctomycetes	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_1099455_16	1096546.WYO_5066	2.665e-06	55.0	COG1487@1|root,COG1487@2|Bacteria,1RIJ3@1224|Proteobacteria,2U8XF@28211|Alphaproteobacteria,1JUWA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1099455_2	1254432.SCE1572_11415	3.095e-107	359.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_1099455_13	1126627.BAWE01000002_gene1420	7.271e-09	63.0	2EFUW@1|root,339M2@2|Bacteria,1R8JP@1224|Proteobacteria,2U5Q7@28211|Alphaproteobacteria,3JYA2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_23140	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HFD3_k127_1099455_0	706587.Desti_3265	6.933e-178	571.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_1099455_1	1205680.CAKO01000038_gene1586	3.921e-111	368.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JRXA@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1099455_4	28444.JODQ01000007_gene5917	5.193e-77	266.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4EGTJ@85012|Streptosporangiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
HFD3_k127_1099455_5	1173024.KI912153_gene32	4.239e-66	235.0	COG0600@1|root,COG0600@2|Bacteria,1G0UB@1117|Cyanobacteria	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1114436_7	357808.RoseRS_1250	3.136e-09	63.0	COG3391@1|root,COG4935@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	DUF11,P_proprotein,VCBS
HFD3_k127_1114436_6	1120950.KB892757_gene6462	3.324e-31	132.0	COG3473@1|root,COG3473@2|Bacteria,2HRMA@201174|Actinobacteria,4DSII@85009|Propionibacteriales	201174|Actinobacteria	Q	Catalyzes the conversion of maleate to fumarate	maiA	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_1114436_0	1297863.APJF01000030_gene829	1.908e-189	603.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_1114436_3	94624.Bpet2729	6.498e-56	211.0	COG3181@1|root,COG3181@2|Bacteria,1NRBP@1224|Proteobacteria,2W0AG@28216|Betaproteobacteria,3T6SK@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1114436_2	1449126.JQKL01000016_gene2869	3.456e-62	224.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,268AT@186813|unclassified Clostridiales	186801|Clostridia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_1114436_5	742733.HMPREF9469_01315	1.633e-54	196.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,220IW@1506553|Lachnoclostridium	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_1114436_1	706587.Desti_0681	7.935e-152	512.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	2|Bacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_1114436_4	1210045.ALNP01000003_gene4322	2.183e-55	204.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1,MFS_1_like,Sugar_tr
HFD3_k127_1135309_3	472759.Nhal_3648	1.14e-33	145.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales	135613|Chromatiales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HFD3_k127_1135309_2	933262.AXAM01000042_gene1821	2.871e-54	212.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MJ19@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Bacterial type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HFD3_k127_1135309_0	706587.Desti_3172	1.267e-108	360.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42Q8T@68525|delta/epsilon subdivisions,2WKQE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HFD3_k127_1135309_1	309801.trd_1210	2.519e-72	257.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia	189775|Thermomicrobia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD3_k127_1143081_5	1173028.ANKO01000041_gene3220	3.194e-100	330.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H9JF@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Conserved region in glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD3_k127_1143081_0	1173028.ANKO01000041_gene3223	4.498e-254	790.0	COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria,1H8CN@1150|Oscillatoriales	1117|Cyanobacteria	E	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD	Fer4_20,Pyr_redox_2
HFD3_k127_1143081_2	392499.Swit_0904	1.029e-139	459.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,2K6JZ@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182,ko:K16874	ko00130,ko00365,ko01100,ko01110,ko01120,map00130,map00365,map01100,map01110,map01120	M00117	R04985,R04986,R10213	RC00391,RC03086	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_1143081_9	1033736.CAHK01000055_gene2916	3.064e-09	60.0	2B4KM@1|root,31XCU@2|Bacteria,2HCZQ@201174|Actinobacteria,4FB69@85019|Brevibacteriaceae	201174|Actinobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD3_k127_1143081_8	1693.BMIN_0710	3.054e-13	78.0	COG3576@1|root,COG3576@2|Bacteria,2IJK2@201174|Actinobacteria	201174|Actinobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD3_k127_1143081_6	234267.Acid_7166	3.09e-38	150.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HFD3_k127_1143081_1	1033743.CAES01000091_gene2824	6.728e-180	586.0	COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,4HB8X@91061|Bacilli,26TYG@186822|Paenibacillaceae	91061|Bacilli	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_1143081_3	1238425.J07HQW2_03635	8.189e-115	392.0	COG0146@1|root,arCOG01512@2157|Archaea,2Y8DU@28890|Euryarchaeota,23S12@183963|Halobacteria	183963|Halobacteria	E	N-methylhydantoinase B acetone carboxylase, alpha subunit	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_1143081_4	1445613.JALM01000003_gene5003	3.091e-110	377.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4E0K0@85010|Pseudonocardiales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_B
HFD3_k127_1143081_7	278957.ABEA03000195_gene469	9.483e-36	138.0	COG5531@1|root,COG5531@2|Bacteria,46T1X@74201|Verrucomicrobia,3K8F3@414999|Opitutae	414999|Opitutae	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HFD3_k127_1143859_2	671143.DAMO_1573	1.713e-117	390.0	COG0006@1|root,COG0006@2|Bacteria,2NP8P@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Creatinase_N,Peptidase_M24
HFD3_k127_1143859_12	292459.STH2788	3.392e-09	66.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
HFD3_k127_1143859_8	671143.DAMO_3021	3.347e-62	224.0	COG1496@1|root,COG1496@2|Bacteria,2NPT5@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HFD3_k127_1143859_0	909663.KI867150_gene875	2.418e-194	616.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR1E@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714,ko:K07715	ko02020,ko02024,map02020,map02024	M00500,M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_1143859_11	335543.Sfum_2293	5.112e-12	74.0	COG1196@1|root,COG1196@2|Bacteria,1NQEI@1224|Proteobacteria,42XZI@68525|delta/epsilon subdivisions,2WTDN@28221|Deltaproteobacteria,2MSDB@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1143859_1	1123376.AUIU01000016_gene231	1.964e-132	440.0	COG5002@1|root,COG5002@2|Bacteria,3J10G@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HFD3_k127_1143859_5	1047013.AQSP01000140_gene2513	3.352e-94	325.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD3_k127_1143859_3	357808.RoseRS_2742	2.678e-116	384.0	COG2957@1|root,COG2957@2|Bacteria,2GAHD@200795|Chloroflexi,37657@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD3_k127_1143859_4	886293.Sinac_3542	2.118e-115	382.0	COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes	203682|Planctomycetes	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD3_k127_1143859_9	13035.Dacsa_0686	2.995e-54	199.0	COG0412@1|root,COG0412@2|Bacteria,1G0PH@1117|Cyanobacteria	1117|Cyanobacteria	Q	dienelactone hydrolase	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_1143859_6	1500257.JQNM01000014_gene2928	1.597e-88	300.0	COG0596@1|root,COG0596@2|Bacteria,1NDHC@1224|Proteobacteria,2UPRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_1143859_7	760568.Desku_0203	1.428e-71	250.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,2613S@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HFD3_k127_1143859_10	1177179.A11A3_04179	2.618e-41	158.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1XH5M@135619|Oceanospirillales	135619|Oceanospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_1166341_9	667014.Thein_2162	1.837e-13	75.0	COG1912@1|root,COG1912@2|Bacteria,2GHAQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HFD3_k127_1166341_6	340177.Cag_0622	4.952e-59	208.0	COG2131@1|root,COG2131@2|Bacteria,1FDBV@1090|Chlorobi	1090|Chlorobi	F	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HFD3_k127_1166341_10	161156.JQKW01000001_gene1454	4.076e-11	68.0	COG0636@1|root,COG0636@2|Bacteria,2GHXH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD3_k127_1166341_5	264462.Bd0009	7.814e-61	217.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2MT1Y@213481|Bdellovibrionales,2WKX1@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD3_k127_1166341_0	1200792.AKYF01000009_gene3002	2.445e-163	524.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,26QYR@186822|Paenibacillaceae	91061|Bacilli	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS08395	Aminotran_3
HFD3_k127_1166341_1	443143.GM18_0001	3.801e-152	492.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,43RXU@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD3_k127_1166341_3	443143.GM18_0002	2.073e-110	368.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,43T1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD3_k127_1166341_4	1459636.NTE_01742	1.405e-85	292.0	COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD3_k127_1166341_7	266117.Rxyl_3013	1.483e-57	208.0	COG1028@1|root,COG1028@2|Bacteria	266117.Rxyl_3013|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1166341_2	1500257.JQNM01000014_gene2912	2.932e-137	443.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_1166341_8	1095769.CAHF01000010_gene1092	2.383e-14	84.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_1187048_4	91464.S7335_2676	2.527e-14	78.0	COG1335@1|root,COG1335@2|Bacteria,1GC0R@1117|Cyanobacteria	1117|Cyanobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_1187048_1	1231391.AMZF01000069_gene2125	6.496e-103	349.0	COG2271@1|root,COG2271@2|Bacteria,1QTYR@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1187048_3	204669.Acid345_2380	1.063e-55	213.0	COG0477@1|root,COG0477@2|Bacteria,3Y334@57723|Acidobacteria,2JIV9@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_1187048_2	204669.Acid345_2380	1.276e-56	214.0	COG0477@1|root,COG0477@2|Bacteria,3Y334@57723|Acidobacteria,2JIV9@204432|Acidobacteriia	204432|Acidobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_1187048_0	1123508.JH636442_gene4074	5.957e-173	549.0	COG2055@1|root,COG2055@2|Bacteria,2J36Z@203682|Planctomycetes	203682|Planctomycetes	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HFD3_k127_119224_0	1254432.SCE1572_35840	6.585e-239	747.0	COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,42PCX@68525|delta/epsilon subdivisions,2WJ1P@28221|Deltaproteobacteria,2YXZV@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD3_k127_119224_2	118168.MC7420_6291	2.597e-56	208.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,1HAC9@1150|Oscillatoriales	1117|Cyanobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_119224_1	204669.Acid345_2166	1.82e-223	702.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
HFD3_k127_119224_3	1095769.CAHF01000001_gene3522	1.35e-48	179.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VS9I@28216|Betaproteobacteria,478RQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HFD3_k127_1212375_0	56780.SYN_00908	4.631e-135	441.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2MQ6A@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_1212375_2	378806.STAUR_3856	6.559e-55	198.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2YYUB@29|Myxococcales	28221|Deltaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD3_k127_1212375_3	269799.Gmet_1760	1.938e-44	167.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WQQM@28221|Deltaproteobacteria,43V74@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Pfam:Methyltransf_26	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HFD3_k127_1212375_6	880073.Calab_0448	9.817e-08	57.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_1212375_4	290397.Adeh_3478	1.371e-29	121.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,431E6@68525|delta/epsilon subdivisions,2WWGA@28221|Deltaproteobacteria,2YVXB@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD3_k127_1212375_7	1240349.ANGC01000009_gene2779	0.0001189	54.0	COG0346@1|root,COG0346@2|Bacteria,2GM8H@201174|Actinobacteria,4G5RC@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.25	ko:K16049	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R04597	RC01610	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_1212375_1	398767.Glov_0364	1.085e-99	340.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,42MXP@68525|delta/epsilon subdivisions,2WMI1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD3_k127_1212375_5	1144310.PMI07_006458	9.923e-17	90.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria,2UV2M@28211|Alphaproteobacteria,4BM48@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
HFD3_k127_1220788_14	1304880.JAGB01000003_gene1134	1.015e-30	128.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD3_k127_1220788_12	1278073.MYSTI_03019	4.852e-54	194.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2YVAI@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator, CarD family	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HFD3_k127_1220788_10	717605.Theco_0247	2.297e-55	203.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,26QP8@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HFD3_k127_1220788_7	243231.GSU0536	8.496e-89	303.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
HFD3_k127_1220788_4	1120973.AQXL01000119_gene531	1.386e-122	401.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,279A5@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD3_k127_1220788_13	247490.KSU1_D0452	2.492e-31	137.0	COG0859@1|root,COG0859@2|Bacteria,2J4DC@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HFD3_k127_1220788_15	439235.Dalk_3378	1.11e-27	118.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MKY4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HFD3_k127_1220788_2	671143.DAMO_3115	5.375e-147	480.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD3_k127_1220788_0	335543.Sfum_0290	2.482e-169	559.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,2MSIQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Transglycosylase	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HFD3_k127_1220788_5	1232410.KI421418_gene2370	4.451e-111	368.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,43S66@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Glycoprotease family	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD3_k127_1220788_11	1410668.JNKC01000004_gene103	8.94e-55	205.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,36DEP@31979|Clostridiaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD3_k127_1220788_9	1123261.AXDW01000003_gene1819	1.187e-64	230.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1X3ZV@135614|Xanthomonadales	135614|Xanthomonadales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD3_k127_1220788_16	1128421.JAGA01000003_gene3195	8.993e-16	81.0	COG0477@1|root,COG2814@2|Bacteria,2NQP3@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	entS	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_1,MFS_3
HFD3_k127_1220788_8	1442599.JAAN01000023_gene1789	2.315e-74	257.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1X60Y@135614|Xanthomonadales	135614|Xanthomonadales	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HFD3_k127_1220788_1	671143.DAMO_2372	3.825e-153	499.0	COG0778@1|root,COG0778@2|Bacteria,2NPP2@2323|unclassified Bacteria	2|Bacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD3_k127_1220788_3	290397.Adeh_3448	5.957e-134	437.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP,Thr_dehydrat_C
HFD3_k127_1220788_6	42256.RradSPS_2897	7.973e-93	317.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4CRYS@84995|Rubrobacteria	84995|Rubrobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HFD3_k127_1227326_3	887062.HGR_01934	1.188e-44	168.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,4ABU5@80864|Comamonadaceae	28216|Betaproteobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_1227326_2	1304876.AZVC01000002_gene689	1.835e-62	227.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,1W81A@1268|Micrococcaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HFD3_k127_1227326_4	1449044.JMLE01000018_gene1661	3.1e-11	74.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1227326_0	443152.MDG893_15387	3.745e-139	458.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria,469ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_1227326_1	1038859.AXAU01000004_gene4411	1.851e-119	395.0	COG0654@1|root,COG0654@2|Bacteria,1QW6Y@1224|Proteobacteria,2TWQJ@28211|Alphaproteobacteria,3JS5Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	MA20_40245	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,NAD_binding_8
HFD3_k127_1227326_5	1218352.B597_003925	1.975e-09	69.0	COG0715@1|root,COG0715@2|Bacteria,1N40U@1224|Proteobacteria,1SG8D@1236|Gammaproteobacteria,1Z0AY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_123647_0	935840.JAEQ01000006_gene2527	1.09e-31	126.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2TXP1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_123647_2	1173263.Syn7502_03004	3.198e-20	98.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_123647_1	359.CN09_33115	1.31e-26	120.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2U6AN@28211|Alphaproteobacteria,4BM26@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_123647_3	1122915.AUGY01000118_gene6526	2.131e-08	62.0	COG0715@1|root,COG0715@2|Bacteria,1UZYY@1239|Firmicutes,4HE24@91061|Bacilli,26RHH@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_1259651_0	1124780.ANNU01000008_gene2662	1.764e-147	488.0	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,47MB7@768503|Cytophagia	976|Bacteroidetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_1259651_1	714943.Mucpa_5289	2.815e-84	285.0	COG4181@1|root,COG4181@2|Bacteria,4NEVZ@976|Bacteroidetes,1IP20@117747|Sphingobacteriia	976|Bacteroidetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_1259651_2	1519464.HY22_13075	6.291e-75	257.0	COG2755@1|root,COG2755@2|Bacteria,1FET3@1090|Chlorobi	1090|Chlorobi	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HFD3_k127_1259651_5	706587.Desti_5142	4.735e-35	145.0	COG1102@1|root,COG1102@2|Bacteria,1R82J@1224|Proteobacteria,42M5Z@68525|delta/epsilon subdivisions,2WMEJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HFD3_k127_1259651_4	246197.MXAN_1937	1.213e-50	184.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,42TVP@68525|delta/epsilon subdivisions,2WQ7U@28221|Deltaproteobacteria,2YXIQ@29|Myxococcales	28221|Deltaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HFD3_k127_1259651_6	909663.KI867150_gene2875	2.707e-15	79.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MS1I@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
HFD3_k127_1259651_7	991905.SL003B_1325	4.917e-15	88.0	COG5305@1|root,COG5305@2|Bacteria,1R9UF@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_1259651_3	1254432.SCE1572_33465	1.633e-54	198.0	COG0819@1|root,COG0819@2|Bacteria	2|Bacteria	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	-	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
HFD3_k127_1271378_4	1532558.JL39_10470	2.059e-17	84.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2UFUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_1271378_3	189753.AXAS01000041_gene2541	1.325e-26	115.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,3JXB7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD3_k127_1271378_2	314230.DSM3645_21107	7.128e-72	259.0	COG3659@1|root,COG3659@2|Bacteria,2IXZU@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
HFD3_k127_1271378_0	247490.KSU1_C1443	1.027e-252	783.0	COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1271378_1	247490.KSU1_C1444	1.655e-147	475.0	COG0523@1|root,COG0523@2|Bacteria,2IXBH@203682|Planctomycetes	203682|Planctomycetes	S	PFAM cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HFD3_k127_1291730_1	675635.Psed_5047	4.474e-21	105.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1291730_0	760568.Desku_2918	1.697e-194	633.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2605J@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_1291730_3	1449126.JQKL01000016_gene2868	1.005e-18	102.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,26967@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_1291730_2	1159870.KB907784_gene3088	1.694e-19	90.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,3T350@506|Alcaligenaceae	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_130660_7	575540.Isop_3481	5.046e-31	128.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	atoS	-	2.7.13.3	ko:K02482,ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_8,PAS_9
HFD3_k127_130660_10	552811.Dehly_0295	6.395e-12	70.0	COG4191@1|root,COG4191@2|Bacteria,2GAMF@200795|Chloroflexi,34CRV@301297|Dehalococcoidia	301297|Dehalococcoidia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8
HFD3_k127_130660_11	935557.ATYB01000008_gene4944	2.077e-05	52.0	COG2202@1|root,COG2203@1|root,COG3290@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3290@2|Bacteria,COG3920@2|Bacteria,1QQZ6@1224|Proteobacteria,2U3V1@28211|Alphaproteobacteria,4BFN9@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	exsG	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HWE_HK,PAS_3,PAS_4,PAS_9
HFD3_k127_130660_1	56780.SYN_02218	0.0	1030.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD3_k127_130660_3	1183377.Py04_0863	6.127e-172	552.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HFD3_k127_130660_2	1444711.CCJF01000003_gene91	2.852e-241	756.0	COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae	204428|Chlamydiae	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HFD3_k127_130660_0	765420.OSCT_2615	0.0	1162.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia	32061|Chloroflexia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD3_k127_130660_4	861299.J421_3786	2.05e-125	413.0	COG0282@1|root,COG0282@2|Bacteria,1ZT9P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HFD3_k127_130660_5	56110.Oscil6304_5661	3.348e-47	177.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HFD3_k127_130660_6	272557.APE_0313.1	4.858e-44	166.0	COG1720@1|root,arCOG00761@2157|Archaea,2XQIA@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HFD3_k127_130660_9	1321781.HMPREF1985_01539	1.995e-20	102.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4H33K@909932|Negativicutes	909932|Negativicutes	S	CBS domain	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HFD3_k127_130660_8	330214.NIDE3895	8.736e-29	120.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HFD3_k127_1328744_3	648757.Rvan_0037	1.737e-78	273.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2U2IH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HFD3_k127_1328744_1	316055.RPE_0607	1.599e-87	305.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HFD3_k127_1328744_2	398767.Glov_2399	3.213e-79	277.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD3_k127_1328744_5	909663.KI867150_gene1130	4.634e-65	231.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HFD3_k127_1328744_4	1048834.TC41_1120	4.815e-72	257.0	COG1028@1|root,COG1028@2|Bacteria,1TR8Y@1239|Firmicutes,4HFAC@91061|Bacilli,279AR@186823|Alicyclobacillaceae	91061|Bacilli	IQ	NAD dependent epimerase/dehydratase family	-	-	-	ko:K07535	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05582	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HFD3_k127_1328744_9	694440.JOMF01000006_gene528	3.191e-05	53.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,2N9YE@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	porD-1	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HFD3_k127_1328744_6	1343739.PAP_04325	3.595e-60	231.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,24341@183968|Thermococci	183968|Thermococci	C	oxidoreductase subunit alpha	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HFD3_k127_1328744_8	273116.14325064	2.801e-11	77.0	COG1014@1|root,arCOG01603@2157|Archaea,2XYDT@28890|Euryarchaeota,242E6@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HFD3_k127_1328744_7	555079.Toce_2138	4.048e-54	205.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,42F9H@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Thiamine pyrophosphate	porB	-	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD3_k127_1328744_0	237368.SCABRO_01193	6.143e-129	428.0	COG0674@1|root,COG0674@2|Bacteria,2IXH6@203682|Planctomycetes	203682|Planctomycetes	C	Pyruvate ferredoxin oxidoreductase and related	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD3_k127_139325_1	479434.Sthe_0262	2.382e-71	255.0	COG0402@1|root,COG0402@2|Bacteria,2G8TD@200795|Chloroflexi,27ZAA@189775|Thermomicrobia	189775|Thermomicrobia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_139325_0	1160137.KB907307_gene2603	2.857e-98	342.0	COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4FZAK@85025|Nocardiaceae	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_139325_2	262316.MAP_1627	1.648e-54	204.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,23625@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_139325_6	66429.JOFL01000019_gene1553	3.815e-06	50.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_139325_5	1144310.PMI07_006532	3.163e-10	71.0	COG0715@1|root,COG0715@2|Bacteria,1NS0V@1224|Proteobacteria,2UI8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_139325_4	1212548.B381_14431	4.619e-11	74.0	COG0715@1|root,COG0715@2|Bacteria,1N40U@1224|Proteobacteria,1SG8D@1236|Gammaproteobacteria,1Z0AY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_139325_3	1122915.AUGY01000118_gene6526	1.227e-11	70.0	COG0715@1|root,COG0715@2|Bacteria,1UZYY@1239|Firmicutes,4HE24@91061|Bacilli,26RHH@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_1395731_6	1266909.AUAG01000045_gene248	2.599e-17	83.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_1395731_8	713586.KB900536_gene1206	0.0003462	48.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MerC,Methyltransf_31
HFD3_k127_1395731_0	1173023.KE650771_gene4388	3.178e-246	767.0	COG0277@1|root,COG0277@2|Bacteria,1G207@1117|Cyanobacteria	1117|Cyanobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HFD3_k127_1395731_3	450851.PHZ_c1673	3.968e-86	295.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1395731_1	290397.Adeh_2253	3.8e-219	698.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
HFD3_k127_1395731_5	338963.Pcar_0643	2.077e-47	175.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,43SIE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD3_k127_1395731_4	378806.STAUR_3769	2.802e-48	183.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2YVUS@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD3_k127_1395731_2	269799.Gmet_0366	9.341e-212	671.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria,43U97@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HFD3_k127_1395731_7	1267535.KB906767_gene1053	2.57e-09	61.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD3_k127_141354_7	1122604.JONR01000001_gene1789	2.496e-05	49.0	COG3181@1|root,COG3181@2|Bacteria,1PHJF@1224|Proteobacteria,1SI76@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_141354_2	269799.Gmet_1927	6.143e-67	240.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,42R4J@68525|delta/epsilon subdivisions,2WMXH@28221|Deltaproteobacteria,43UGP@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	DUF1517,Tim44
HFD3_k127_141354_0	1123501.KB902290_gene1571	9.486e-187	604.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_141354_5	1082931.KKY_2644	2.306e-47	184.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_141354_4	1123501.KB902290_gene1570	1.981e-52	200.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_141354_3	1120983.KB894571_gene2468	8.599e-66	238.0	COG1073@1|root,COG1073@2|Bacteria,1PJHR@1224|Proteobacteria,2U2QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_141354_6	1415166.NONO_c26800	5.245e-18	97.0	COG0006@1|root,COG0006@2|Bacteria,2IAJ8@201174|Actinobacteria,4G4XI@85025|Nocardiaceae	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_142961_0	861299.J421_2352	1.621e-135	444.0	COG4102@1|root,COG4102@2|Bacteria,1ZSZ1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HFD3_k127_142961_1	246197.MXAN_6410	4.33e-118	397.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,42YPE@68525|delta/epsilon subdivisions,2WU63@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HFD3_k127_142961_4	1232410.KI421418_gene2171	6.143e-11	70.0	COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria,42XU4@68525|delta/epsilon subdivisions,2WSMH@28221|Deltaproteobacteria,43VU5@69541|Desulfuromonadales	28221|Deltaproteobacteria	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
HFD3_k127_142961_3	1121918.ARWE01000001_gene3290	1.319e-14	81.0	2DQD7@1|root,3361P@2|Bacteria,1NAB8@1224|Proteobacteria,42WKD@68525|delta/epsilon subdivisions,2WRQT@28221|Deltaproteobacteria,43SQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HFD3_k127_142961_5	710686.Mycsm_01053	0.0004458	49.0	COG5662@1|root,COG5662@2|Bacteria,2GNCC@201174|Actinobacteria,234PS@1762|Mycobacteriaceae	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_142961_2	671143.DAMO_2841	2.368e-29	123.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_1435780_5	1057002.KB905370_gene4498	1.106e-09	61.0	COG0517@1|root,COG0517@2|Bacteria,1NCNH@1224|Proteobacteria,2UHM3@28211|Alphaproteobacteria,4BBGV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HFD3_k127_1435780_3	794903.OPIT5_12085	3.945e-38	154.0	COG2169@1|root,COG4936@1|root,COG2169@2|Bacteria,COG4936@2|Bacteria,46UZR@74201|Verrucomicrobia,3K795@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
HFD3_k127_1435780_1	671143.DAMO_1166	6.13e-90	301.0	COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HFD3_k127_1435780_0	671143.DAMO_1165	5.035e-259	808.0	COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD3_k127_1435780_2	671143.DAMO_1164	5.261e-60	213.0	COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria	2|Bacteria	C	cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD3_k127_1442512_4	338966.Ppro_0982	4.581e-51	186.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,43TK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HFD3_k127_1442512_9	1115515.EV102420_02_02040	0.0001781	50.0	COG2165@1|root,COG2165@2|Bacteria,1RDKI@1224|Proteobacteria,1S4ND@1236|Gammaproteobacteria,3XN4R@561|Escherichia	1236|Gammaproteobacteria	NU	Prokaryotic N-terminal methylation motif	ppdA	-	-	ko:K02679	-	-	-	-	ko00000,ko02044	-	-	-	N_methyl
HFD3_k127_1442512_7	56780.SYN_01760	1.042e-07	59.0	COG4967@1|root,COG4967@2|Bacteria,1NI49@1224|Proteobacteria	1224|Proteobacteria	NU	type IV pilus modification protein PilV	pilV	-	-	ko:K02458,ko:K02671	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	N_methyl
HFD3_k127_1442512_8	713586.KB900536_gene2027	4.097e-05	53.0	COG4966@1|root,COG4966@2|Bacteria,1RE89@1224|Proteobacteria,1RPD5@1236|Gammaproteobacteria,1X2H2@135613|Chromatiales	1236|Gammaproteobacteria	NU	Type IV Pilus-assembly protein W	pilW	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
HFD3_k127_1442512_5	330214.NIDE0858	3.858e-28	119.0	COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD3_k127_1442512_2	525146.Ddes_0128	5.468e-62	219.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,2M82V@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD3_k127_1442512_3	706587.Desti_4868	4.827e-52	196.0	COG2812@1|root,COG2812@2|Bacteria,1QVB3@1224|Proteobacteria,42SBC@68525|delta/epsilon subdivisions,2WPCK@28221|Deltaproteobacteria,2MQJA@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase III, delta prime subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HFD3_k127_1442512_0	56780.SYN_00558	1.776e-185	594.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD3_k127_1442512_1	1128398.Curi_c01230	5.776e-83	282.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,268XK@186813|unclassified Clostridiales	186801|Clostridia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD3_k127_1442512_6	102125.Xen7305DRAFT_00032800	4.698e-13	68.0	COG4251@1|root,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,3VHPV@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	aphA	-	2.7.13.3	ko:K11354	ko02020,map02020	M00510	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PHY
HFD3_k127_1456658_3	56780.SYN_00815	2.114e-36	147.0	COG1807@1|root,COG1807@2|Bacteria,1MY0U@1224|Proteobacteria,42QGD@68525|delta/epsilon subdivisions,2WM6Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_1456658_1	1121405.dsmv_1156	2.306e-93	316.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,42PE4@68525|delta/epsilon subdivisions,2WK83@28221|Deltaproteobacteria,2MPWY@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HFD3_k127_1456658_4	1041159.AZUW01000038_gene2715	5.901e-29	133.0	2C1UQ@1|root,33VUD@2|Bacteria,1RM45@1224|Proteobacteria,2UBKR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_1456658_2	472759.Nhal_0611	1.952e-60	223.0	COG0438@1|root,COG0438@2|Bacteria,1MZH2@1224|Proteobacteria,1S9AM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_1456658_0	631362.Thi970DRAFT_01496	2.071e-100	339.0	COG0438@1|root,COG0438@2|Bacteria,1R01U@1224|Proteobacteria,1RREV@1236|Gammaproteobacteria,1WWC3@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HFD3_k127_1473047_6	1499967.BAYZ01000178_gene4647	1.473e-65	232.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03631,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
HFD3_k127_1473047_8	744872.Spica_1603	5.4e-26	108.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD3_k127_1473047_1	596151.DesfrDRAFT_2946	1.742e-146	473.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD3_k127_1473047_4	880072.Desac_0378	1.469e-75	264.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2MQKB@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HFD3_k127_1473047_0	1232410.KI421412_gene109	1.008e-158	511.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,43TD6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HFD3_k127_1473047_2	224324.aq_782	1.452e-125	415.0	COG0141@1|root,COG0141@2|Bacteria,2G3NF@200783|Aquificae	200783|Aquificae	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HFD3_k127_1473047_3	443143.GM18_4152	7.527e-79	267.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,43SWF@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	imidazoleglycerol-phosphate dehydratase activity	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HFD3_k127_1473047_5	748449.Halha_0992	2.298e-73	258.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,3WAQQ@53433|Halanaerobiales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HFD3_k127_1473047_7	118163.Ple7327_2925	7.081e-52	195.0	COG0106@1|root,COG0106@2|Bacteria,1G1S9@1117|Cyanobacteria,3VIJV@52604|Pleurocapsales	1117|Cyanobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HFD3_k127_1554514_4	935840.JAEQ01000004_gene646	1.864e-18	96.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1554514_5	317619.ANKN01000109_gene1353	2.314e-08	57.0	COG1451@1|root,COG1451@2|Bacteria,1G1B3@1117|Cyanobacteria,1MP48@1212|Prochloraceae	1117|Cyanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HFD3_k127_1554514_1	266265.Bxe_A2626	2.163e-105	357.0	COG0006@1|root,COG0006@2|Bacteria,1N9PS@1224|Proteobacteria	1224|Proteobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_1554514_2	189753.AXAS01000041_gene2534	5.346e-88	303.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1554514_0	163908.KB235896_gene3710	9.536e-137	458.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_1554514_3	189753.AXAS01000041_gene2534	2.11e-72	256.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1562977_11	1120949.KB903294_gene4211	4.244e-05	52.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,4D94Q@85008|Micromonosporales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_1562977_10	1231391.AMZF01000020_gene1928	9.116e-34	143.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_1562977_4	1040989.AWZU01000084_gene3851	3.178e-88	301.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,3JRRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
HFD3_k127_1562977_9	997346.HMPREF9374_1261	5.013e-36	153.0	COG0477@1|root,COG2814@2|Bacteria,1TS3C@1239|Firmicutes,4HC3B@91061|Bacilli,27BQQ@186824|Thermoactinomycetaceae	91061|Bacilli	EGP	Nucleoside H+ symporter	ywbF	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HFD3_k127_1562977_7	497964.CfE428DRAFT_0398	3.864e-48	178.0	COG5483@1|root,COG5483@2|Bacteria,46TB0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HFD3_k127_1562977_5	1396418.BATQ01000175_gene2797	3.46e-71	250.0	COG0745@1|root,COG0745@2|Bacteria,46UC4@74201|Verrucomicrobia,2IUBT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD3_k127_1562977_2	1396141.BATP01000022_gene317	1.507e-254	812.0	COG0642@1|root,COG2205@2|Bacteria,46UHY@74201|Verrucomicrobia,2ITGS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HFD3_k127_1562977_6	1278073.MYSTI_00154	2.611e-69	241.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,42SC9@68525|delta/epsilon subdivisions,2WPDZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HFD3_k127_1562977_8	497964.CfE428DRAFT_4927	3.211e-37	142.0	2C1V4@1|root,2ZQKU@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	-
HFD3_k127_1562977_0	1396418.BATQ01000175_gene2802	2.19e-290	906.0	COG2216@1|root,COG2216@2|Bacteria,46SEM@74201|Verrucomicrobia,2ITIQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	-	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HFD3_k127_1562977_1	215803.DB30_3387	1.87e-256	801.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,42NCD@68525|delta/epsilon subdivisions,2WJ03@28221|Deltaproteobacteria,2YWFC@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HFD3_k127_1562977_3	596152.DesU5LDRAFT_0535	9.696e-174	562.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2M85I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD3_k127_1575652_0	153721.MYP_2149	3.994e-89	302.0	COG1368@1|root,COG1368@2|Bacteria,4NIAA@976|Bacteroidetes,47MRX@768503|Cytophagia	976|Bacteroidetes	M	Sulfatase	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
HFD3_k127_1575652_5	319003.Bra1253DRAFT_08264	2.057e-43	176.0	COG1696@1|root,COG1696@2|Bacteria,1R5WP@1224|Proteobacteria,2U7N8@28211|Alphaproteobacteria,3K3CQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1575652_2	333138.LQ50_20135	1.088e-73	254.0	COG1335@1|root,COG1335@2|Bacteria,1VA32@1239|Firmicutes,4HKVT@91061|Bacilli,1ZHJR@1386|Bacillus	91061|Bacilli	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_1575652_4	401526.TcarDRAFT_1875	1.239e-53	210.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4H2KV@909932|Negativicutes	909932|Negativicutes	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_1575652_1	933115.GPDM_10360	7.842e-76	265.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HATR@91061|Bacilli,26EWK@186818|Planococcaceae	91061|Bacilli	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_1575652_3	1094508.Tsac_2555	4.004e-72	254.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,42F60@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HFD3_k127_1581394_8	1160137.KB907308_gene6466	7.587e-17	88.0	COG2141@1|root,COG2141@2|Bacteria,2IFUW@201174|Actinobacteria,4G5C8@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_1581394_2	204669.Acid345_1153	4.223e-46	180.0	COG0860@1|root,COG0860@2|Bacteria,3Y3M0@57723|Acidobacteria,2JI9V@204432|Acidobacteriia	204432|Acidobacteriia	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HFD3_k127_1581394_0	1142394.PSMK_08370	2.318e-81	282.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD3_k127_1581394_9	1267533.KB906736_gene868	3.14e-15	86.0	COG0596@1|root,COG0596@2|Bacteria,3Y4YX@57723|Acidobacteria,2JJKK@204432|Acidobacteriia	204432|Acidobacteriia	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_1581394_6	877455.Metbo_0319	3.161e-28	120.0	COG4032@1|root,arCOG01613@2157|Archaea,2XYBY@28890|Euryarchaeota,23PJE@183925|Methanobacteria	183925|Methanobacteria	S	sulfopyruvate decarboxylase, alpha subunit	comD	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD3_k127_1581394_3	1038860.AXAP01000005_gene8094	1.501e-45	171.0	COG0028@1|root,COG0028@2|Bacteria,1R610@1224|Proteobacteria,2U43S@28211|Alphaproteobacteria,3JTBV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HFD3_k127_1581394_4	1134413.ANNK01000087_gene240	1.772e-44	177.0	COG2223@1|root,COG2223@2|Bacteria,1UJI3@1239|Firmicutes,4IT9X@91061|Bacilli,1ZSAX@1386|Bacillus	91061|Bacilli	P	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1581394_1	1499968.TCA2_4364	7.067e-79	274.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli,26QD0@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_1581394_7	472759.Nhal_0470	1.189e-26	113.0	2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,1SD5T@1236|Gammaproteobacteria,1X269@135613|Chromatiales	135613|Chromatiales	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HFD3_k127_1581394_5	221288.JH992901_gene1253	1.218e-41	158.0	COG3805@1|root,COG3805@2|Bacteria,1G7MF@1117|Cyanobacteria,1JM07@1189|Stigonemataceae	1117|Cyanobacteria	Q	Dopa 4,5-dioxygenase family	-	-	-	ko:K10253	-	-	-	-	ko00000,ko01000	-	-	-	DOPA_dioxygen
HFD3_k127_1599787_3	1210884.HG799464_gene10628	1.214e-26	114.0	COG1595@1|root,COG1595@2|Bacteria,2J08Y@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_1599787_5	56780.SYN_02038	9.529e-13	80.0	COG3170@1|root,COG3170@2|Bacteria,1NHGQ@1224|Proteobacteria,42X64@68525|delta/epsilon subdivisions,2WSMQ@28221|Deltaproteobacteria,2MQPS@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,zf-HC2
HFD3_k127_1599787_4	717606.PaecuDRAFT_1071	4.819e-25	111.0	COG1051@1|root,COG1051@2|Bacteria,1VG8K@1239|Firmicutes,4HPCK@91061|Bacilli,26XWF@186822|Paenibacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
HFD3_k127_1599787_1	502025.Hoch_4484	3.782e-99	334.0	COG5424@1|root,COG5424@2|Bacteria,1Q9R2@1224|Proteobacteria,434J3@68525|delta/epsilon subdivisions,2X8WX@28221|Deltaproteobacteria,2Z0SN@29|Myxococcales	28221|Deltaproteobacteria	H	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
HFD3_k127_1599787_0	1282356.H045_08475	1.075e-187	595.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1YMN5@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	iZ_1308.Z4900	Pyr_redox_2,Pyr_redox_dim
HFD3_k127_1599787_2	1089553.Tph_c19760	9.991e-44	166.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_1605497_2	671143.DAMO_2497	3.399e-26	110.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD3_k127_1605497_6	909663.KI867150_gene1181	8.79e-05	45.0	COG3668@1|root,COG3668@2|Bacteria,1PJWN@1224|Proteobacteria,42TM0@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HFD3_k127_1605497_3	671143.DAMO_2496	6.938e-19	87.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HFD3_k127_1605497_4	1121405.dsmv_1861	2.48e-07	53.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,PTS_EIIA_2
HFD3_k127_1605497_0	1121939.L861_22705	1.877e-42	158.0	2CZ4M@1|root,32T5I@2|Bacteria,1N344@1224|Proteobacteria,1SRM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1605497_5	926550.CLDAP_38520	2.466e-05	51.0	COG1708@1|root,COG1708@2|Bacteria,2G9B2@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HFD3_k127_1605497_1	134676.ACPL_2105	1.273e-26	114.0	COG2271@1|root,COG2271@2|Bacteria,2GIS1@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_1606747_5	383372.Rcas_1973	1.006e-25	121.0	COG2304@1|root,COG2304@2|Bacteria,2GACU@200795|Chloroflexi,375FC@32061|Chloroflexia	32061|Chloroflexia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HFD3_k127_1606747_2	575540.Isop_2743	3.963e-45	175.0	COG1721@1|root,COG1721@2|Bacteria,2IY59@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD3_k127_1606747_0	215803.DB30_7393	2.078e-92	309.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2Z04D@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
HFD3_k127_1606747_6	1227495.C487_06995	4.8e-08	55.0	COG0607@1|root,arCOG06301@1|root,arCOG02021@2157|Archaea,arCOG06301@2157|Archaea,2XW44@28890|Euryarchaeota,23S0R@183963|Halobacteria	183963|Halobacteria	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD3_k127_1606747_7	904296.HMPREF9124_1587	0.0002768	48.0	COG0607@1|root,COG0607@2|Bacteria,1V5BS@1239|Firmicutes,24H9M@186801|Clostridia,2PRXT@265975|Oribacterium	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	ko:K03972	-	-	-	-	ko00000	-	-	-	Rhodanese
HFD3_k127_1606747_1	713587.THITH_08925	6.115e-73	256.0	COG0526@1|root,COG4243@1|root,COG0526@2|Bacteria,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	3.5.1.104	ko:K12057,ko:K22278	-	-	-	-	ko00000,ko01000,ko02044	3.A.7.11.1	-	-	Thioredoxin_4,VKOR
HFD3_k127_1606747_3	497964.CfE428DRAFT_2238	1.519e-37	151.0	COG1999@1|root,COG1999@2|Bacteria,46VZB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD3_k127_1606747_4	420324.KI911972_gene3029	3.024e-31	130.0	COG1999@1|root,COG1999@2|Bacteria,1N6WC@1224|Proteobacteria,2VFHX@28211|Alphaproteobacteria	1224|Proteobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	AhpC-TSA,SCO1-SenC
HFD3_k127_1630875_4	404380.Gbem_1249	8.794e-43	165.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,42WEW@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	cytochrome c	norC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
HFD3_k127_1630875_8	880072.Desac_1083	1.436e-31	128.0	COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WRIB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CBS domain	-	-	-	ko:K04767,ko:K07168,ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
HFD3_k127_1630875_2	926550.CLDAP_14230	2.399e-79	267.0	COG1839@1|root,COG1839@2|Bacteria,2G6BH@200795|Chloroflexi	200795|Chloroflexi	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HFD3_k127_1630875_5	357808.RoseRS_0912	3.303e-41	163.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,377HX@32061|Chloroflexia	32061|Chloroflexia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_1630875_6	309801.trd_1809	1.782e-37	153.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_1630875_7	289376.THEYE_A0363	3.081e-37	146.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_1630875_3	330214.NIDE3875	7.267e-54	203.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,3J0TG@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HFD3_k127_1630875_0	247490.KSU1_D0949	2.262e-142	463.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HFD3_k127_1630875_1	247490.KSU1_D0948	2.857e-115	385.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD3_k127_1630875_9	195250.CM001776_gene1081	3.745e-28	115.0	COG0334@1|root,COG0334@2|Bacteria,1G0WP@1117|Cyanobacteria,1H01S@1129|Synechococcus	1117|Cyanobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	-	-	-	-	-	-	-	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD3_k127_1637341_0	266779.Meso_2926	3.356e-130	432.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_1637341_1	1173263.Syn7502_03004	1.044e-43	172.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1648114_1	1231391.AMZF01000094_gene122	1.038e-170	554.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_1648114_3	446468.Ndas_4520	9.9e-12	72.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	catD	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD3_k127_1648114_0	469383.Cwoe_4084	1.55e-243	766.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	2|Bacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_1648114_2	1123228.AUIH01000063_gene3053	2.183e-139	467.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XJ23@135619|Oceanospirillales	135619|Oceanospirillales	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_1648114_4	998674.ATTE01000001_gene3828	3.152e-10	63.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,1S5V9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_1659369_3	1163617.SCD_n00150	3.291e-58	208.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.265	ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
HFD3_k127_1659369_0	335543.Sfum_2531	4.076e-104	351.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2MRAV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HFD3_k127_1659369_1	63737.Npun_R2053	1.88e-96	329.0	COG1073@1|root,COG1073@2|Bacteria,1GGWP@1117|Cyanobacteria,1HTF4@1161|Nostocales	1117|Cyanobacteria	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
HFD3_k127_1659369_5	1122915.AUGY01000118_gene6536	4.725e-26	120.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1659369_7	1142394.PSMK_30210	6.713e-07	56.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_1659369_6	1236973.JCM9157_2253	3.409e-13	76.0	2ERNT@1|root,33J87@2|Bacteria,1VMAP@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1659369_2	68219.JNXI01000002_gene3959	6.269e-86	294.0	2EYIJ@1|root,33RSC@2|Bacteria,2IPA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1659369_4	234267.Acid_5523	1.36e-51	186.0	COG1651@1|root,COG1651@2|Bacteria,3Y87P@57723|Acidobacteria	2|Bacteria	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
HFD3_k127_1659401_2	1041147.AUFB01000019_gene5557	5.348e-47	177.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TZDF@28211|Alphaproteobacteria,4BP1X@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HFD3_k127_1659401_0	443152.MDG893_15015	1.444e-74	259.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,1RNY1@1236|Gammaproteobacteria,46A35@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	KR domain	-	-	1.1.1.304,1.1.1.76	ko:K03366	ko00650,map00650	-	R02855,R02946,R03707,R09078,R10505	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD3_k127_1659401_7	1437603.BMON_0422	1.734e-07	63.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1659401_4	111781.Lepto7376_3386	7.736e-22	98.0	COG0346@1|root,COG0346@2|Bacteria,1G504@1117|Cyanobacteria,1HAPB@1150|Oscillatoriales	1117|Cyanobacteria	E	Lactoylglutathione lyase	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_1659401_1	671143.DAMO_0383	2.146e-64	233.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD3_k127_1659401_3	391625.PPSIR1_08911	1.449e-37	151.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HFD3_k127_1659401_5	1124780.ANNU01000012_gene3901	6.501e-15	84.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PDZ@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA,PD40
HFD3_k127_1659401_6	1123487.KB892857_gene2508	6.07e-11	66.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,2KV3W@206389|Rhodocyclales	206389|Rhodocyclales	I	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MFS_1
HFD3_k127_1669312_1	909663.KI867150_gene2065	1.834e-34	140.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_1669312_0	1232410.KI421422_gene2004	1.726e-107	363.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,43SB6@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	TolB amino-terminal domain	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD3_k127_1669312_2	1123392.AQWL01000005_gene2943	0.0001232	53.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria,1KSX4@119069|Hydrogenophilales	119069|Hydrogenophilales	M	TonB C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
HFD3_k127_1674331_0	869210.Marky_0826	1.384e-255	797.0	COG0247@1|root,COG0247@2|Bacteria,1WIPC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD3_k127_1674331_3	398767.Glov_3102	7.436e-82	281.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,42M2F@68525|delta/epsilon subdivisions,2WKUG@28221|Deltaproteobacteria,43THQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	regulatory protein IclR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HFD3_k127_1674331_1	330214.NIDE2040	8.964e-159	514.0	COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae	40117|Nitrospirae	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HFD3_k127_1674331_4	358681.BBR47_01720	2.828e-81	274.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae	91061|Bacilli	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	iYO844.BSU00750	GATase
HFD3_k127_1674331_6	456442.Mboo_2033	2.882e-22	101.0	COG0441@1|root,arCOG00401@2157|Archaea,2Y4U7@28890|Euryarchaeota,2NB51@224756|Methanomicrobia	224756|Methanomicrobia	J	Archaea-specific editing domain of threonyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-Thr_ED
HFD3_k127_1674331_8	926550.CLDAP_35480	1.456e-06	57.0	COG3103@1|root,COG3693@1|root,COG3103@2|Bacteria,COG3693@2|Bacteria,COG4991@2|Bacteria,2GBGU@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
HFD3_k127_1674331_2	1120936.KB907221_gene2112	3.751e-91	310.0	COG2159@1|root,COG2159@2|Bacteria,2GN9D@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_1674331_5	357808.RoseRS_2180	1.232e-50	198.0	COG0477@1|root,COG2814@2|Bacteria,2G5SP@200795|Chloroflexi,37808@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K18926	-	M00715	-	-	ko00000,ko00002,ko02000	2.A.1.3.30	-	-	MFS_1
HFD3_k127_1674331_7	101510.RHA1_ro00657	2.07e-19	91.0	COG1359@1|root,COG1359@2|Bacteria,2GSE1@201174|Actinobacteria,4G2S4@85025|Nocardiaceae	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HFD3_k127_1679539_4	675635.Psed_4284	3.256e-37	147.0	COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B	-	-	-	-	-	-	-	-	-	-	-	-	LigB
HFD3_k127_1679539_1	247633.GP2143_12991	2.27e-82	286.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1S0H1@1236|Gammaproteobacteria,1JBTT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Zn-dependent alcohol dehydrogenases	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_1679539_6	1207075.PputUW4_02091	2.84e-13	78.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ANAPC5,Peptidase_C39_2,TPR_16,TPR_19,TPR_2,TPR_8
HFD3_k127_1679539_5	421052.F945_02699	1.134e-32	143.0	COG2223@1|root,COG2223@2|Bacteria,1QU76@1224|Proteobacteria,1T1PJ@1236|Gammaproteobacteria,3NJ64@468|Moraxellaceae	1236|Gammaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1679539_3	1227487.C474_06782	2.281e-45	174.0	COG1028@1|root,arCOG01259@2157|Archaea,2XVZM@28890|Euryarchaeota,23UKP@183963|Halobacteria	183963|Halobacteria	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_1679539_7	1869.MB27_00630	0.0003393	50.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HFD3_k127_1679539_2	243231.GSU2716	3.477e-78	269.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,42QXT@68525|delta/epsilon subdivisions,2WN0R@28221|Deltaproteobacteria,43T0X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HFD3_k127_1679539_0	316058.RPB_4416	3.517e-163	537.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_1680632_3	1499967.BAYZ01000085_gene5179	3.937e-54	202.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_5	886293.Sinac_2265	7.566e-29	126.0	COG2520@1|root,COG2520@2|Bacteria,2J555@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM methyltransferase FkbM family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD3_k127_1680632_8	1370125.AUWT01000029_gene549	7.213e-12	78.0	COG2244@1|root,COG2244@2|Bacteria,2HQKS@201174|Actinobacteria,237HG@1762|Mycobacteriaceae	201174|Actinobacteria	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HFD3_k127_1680632_11	641149.HMPREF9016_00022	3.551e-08	65.0	COG0438@1|root,COG0438@2|Bacteria,1PEZ0@1224|Proteobacteria,2W92V@28216|Betaproteobacteria,2KT86@206351|Neisseriales	206351|Neisseriales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_1	1499967.BAYZ01000085_gene5180	1.056e-106	358.0	COG0438@1|root,COG0438@2|Bacteria,2NRDY@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	tuaC	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K16697	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	iYO844.BSU35590	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_9	1173022.Cri9333_3493	8.274e-11	74.0	COG0438@1|root,COG0438@2|Bacteria,1G0WZ@1117|Cyanobacteria,1HH7R@1150|Oscillatoriales	1117|Cyanobacteria	M	SPTR Glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_12	102232.GLO73106DRAFT_00000930	2.538e-05	57.0	2DNJU@1|root,32XV9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1680632_4	56110.Oscil6304_3545	8.288e-41	166.0	COG0438@1|root,COG0438@2|Bacteria,1G40J@1117|Cyanobacteria,1H9VA@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_0	1499967.BAYZ01000026_gene1631	2.325e-178	580.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_1680632_2	56110.Oscil6304_3546	1.198e-99	340.0	COG0438@1|root,COG0438@2|Bacteria,1G4KT@1117|Cyanobacteria,1HCQM@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
HFD3_k127_1680632_10	1122925.KB895380_gene3997	4.686e-09	68.0	29YR2@1|root,30KKX@2|Bacteria,1U0GK@1239|Firmicutes,4I9UQ@91061|Bacilli,27201@186822|Paenibacillaceae	91061|Bacilli	S	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
HFD3_k127_1680632_7	765911.Thivi_2438	2.091e-22	112.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WWX7@135613|Chromatiales	135613|Chromatiales	U	Type II secretory pathway component ExeA	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HFD3_k127_1680632_6	671143.DAMO_2217	3.485e-27	116.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD3_k127_1684715_0	1217720.ALOX01000137_gene3957	2.135e-86	295.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_1684715_2	1207063.P24_08344	1.595e-66	236.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2UABA@28211|Alphaproteobacteria,2JT45@204441|Rhodospirillales	204441|Rhodospirillales	I	Carboxylesterase family	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3
HFD3_k127_1684715_1	91464.S7335_3632	4.898e-78	270.0	COG0491@1|root,COG0491@2|Bacteria,1G04I@1117|Cyanobacteria,1GYPD@1129|Synechococcus	1117|Cyanobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HFD3_k127_1711568_16	1201290.M902_1513	1.659e-35	136.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2MSUN@213481|Bdellovibrionales,2WJ9X@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD3_k127_1711568_0	443144.GM21_0005	0.0	1058.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD3_k127_1711568_6	1232410.KI421422_gene2029	4.235e-101	339.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,43TUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HFD3_k127_1711568_20	349124.Hhal_1228	5.225e-15	76.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1WZNE@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HFD3_k127_1711568_18	243231.GSU3468	7.224e-20	93.0	COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42VBC@68525|delta/epsilon subdivisions,2WRF0@28221|Deltaproteobacteria,43VN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HFD3_k127_1711568_17	936375.HMPREF1152_1807	2.101e-20	93.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,3WDPC@538999|Clostridiales incertae sedis	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HFD3_k127_1711568_7	443143.GM18_4521	5.897e-100	346.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HFD3_k127_1711568_15	591001.Acfer_2078	4.384e-39	157.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,4H41I@909932|Negativicutes	909932|Negativicutes	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HFD3_k127_1711568_4	671143.DAMO_2468	5.336e-168	536.0	COG0821@1|root,COG0821@2|Bacteria,2NNPV@2323|unclassified Bacteria	2|Bacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430,iJN678.gcpE	GcpE
HFD3_k127_1711568_2	1232410.KI421428_gene1211	1e-231	730.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,43RZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Aminoacyl-tRNA editing domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HFD3_k127_1711568_11	1121918.ARWE01000001_gene2286	4.467e-78	268.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,43S93@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HFD3_k127_1711568_10	479434.Sthe_1496	8.305e-91	307.0	COG0351@1|root,COG0351@2|Bacteria,2G5R7@200795|Chloroflexi,27XQP@189775|Thermomicrobia	189775|Thermomicrobia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HFD3_k127_1711568_1	330214.NIDE2073	1.269e-302	940.0	COG1389@1|root,COG1389@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
HFD3_k127_1711568_3	330214.NIDE2074	1.588e-202	634.0	COG1697@1|root,COG1697@2|Bacteria	2|Bacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DUF2220,DUF3322,TP6A_N
HFD3_k127_1711568_12	489825.LYNGBM3L_10420	2.211e-56	217.0	COG3379@1|root,COG3379@2|Bacteria,1G1KP@1117|Cyanobacteria,1H87X@1150|Oscillatoriales	1117|Cyanobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD3_k127_1711568_19	330214.NIDE2074	2.62e-15	78.0	COG1697@1|root,COG1697@2|Bacteria	2|Bacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DUF2220,DUF3322,TP6A_N
HFD3_k127_1711568_14	56780.SYN_01265	3.583e-46	173.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MRQQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD3_k127_1711568_13	909663.KI867149_gene3360	2.349e-53	192.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MQJI@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD3_k127_1711568_9	56780.SYN_01262	1.322e-93	313.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MQW9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD3_k127_1711568_21	69042.WH5701_04870	4.1e-09	66.0	COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,1G1IK@1117|Cyanobacteria,1GZ3H@1129|Synechococcus	1117|Cyanobacteria	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase,STAS,cNMP_binding
HFD3_k127_1711568_5	56780.SYN_01263	8.305e-131	429.0	COG1127@1|root,COG2199@1|root,COG1127@2|Bacteria,COG2199@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MQX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
HFD3_k127_1711568_8	456442.Mboo_1046	3.078e-96	329.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD3_k127_1714098_3	1394178.AWOO02000064_gene65	6.179e-05	51.0	COG3473@1|root,COG3473@2|Bacteria,2GKP7@201174|Actinobacteria,4EMAU@85012|Streptosporangiales	201174|Actinobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_1714098_0	266117.Rxyl_1199	9.67e-28	119.0	COG2846@1|root,COG2846@2|Bacteria	2|Bacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,Hemerythrin,NnrS
HFD3_k127_1723545_1	1382306.JNIM01000001_gene2428	5.211e-168	531.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD3_k127_1723545_0	485913.Krac_9358	8.522e-241	749.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_1723545_2	1242864.D187_006054	2.211e-87	302.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42RDN@68525|delta/epsilon subdivisions,2WMR0@28221|Deltaproteobacteria,2YUAJ@29|Myxococcales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD3_k127_1723545_4	398580.Dshi_4186	7.562e-76	263.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_1723545_5	1173024.KI912153_gene32	1.55e-71	250.0	COG0600@1|root,COG0600@2|Bacteria,1G0UB@1117|Cyanobacteria	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1723545_6	1173024.KI912153_gene33	5.723e-58	215.0	COG0715@1|root,COG0715@2|Bacteria,1GGUC@1117|Cyanobacteria	1117|Cyanobacteria	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_1723545_7	671143.DAMO_2791	1.316e-27	116.0	COG1193@1|root,COG1193@2|Bacteria,2NRN7@2323|unclassified Bacteria	2|Bacteria	L	Smr domain	mutS2	GO:0000018,GO:0008150,GO:0009892,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HFD3_k127_1723545_3	575540.Isop_2276	7.895e-84	284.0	COG0761@1|root,COG0761@2|Bacteria,2IXK4@203682|Planctomycetes	203682|Planctomycetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD3_k127_1727816_0	573370.DMR_44700	1.012e-208	669.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2M85I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD3_k127_1727816_5	1123368.AUIS01000024_gene953	2.881e-45	177.0	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,PrmA
HFD3_k127_1727816_4	448385.sce4660	7.879e-73	261.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2X6ZP@28221|Deltaproteobacteria,2Z3JZ@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_1727816_6	525904.Tter_0841	4.621e-38	156.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	ocd	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_1727816_3	1318628.MARLIPOL_01155	3.536e-75	261.0	COG0500@1|root,COG2226@2|Bacteria,1QYC9@1224|Proteobacteria,1S4V4@1236|Gammaproteobacteria,46900@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HFD3_k127_1727816_11	1298860.AUEM01000001_gene1759	0.0009014	46.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HFD3_k127_1727816_1	189753.AXAS01000013_gene5867	6.469e-164	525.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,3JSJF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HFD3_k127_1727816_10	1331060.RLDS_01630	4.753e-09	60.0	COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,2U4GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HFD3_k127_1727816_9	1463820.JOGW01000008_gene1433	2.642e-13	81.0	COG0715@1|root,COG0715@2|Bacteria,2I9KK@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1727816_2	1340434.AXVA01000012_gene2953	3.699e-107	364.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,4HBJ1@91061|Bacilli	91061|Bacilli	C	Conserved carboxylase domain	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_1727816_8	671143.DAMO_1892	6.057e-25	105.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HFD3_k127_1727816_7	671143.DAMO_1891	1.256e-37	146.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	ko:K07063	-	-	-	-	ko00000	-	-	-	PIN_3
HFD3_k127_1742478_0	1232410.KI421422_gene2032	7.618e-283	890.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD3_k127_1742478_10	220664.PFL_4422	1.919e-06	58.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1YM3Y@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478	CobS
HFD3_k127_1742478_8	395493.BegalDRAFT_2029	5.541e-37	156.0	COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HFD3_k127_1742478_2	1123072.AUDH01000002_gene2353	6.756e-99	336.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine synthase	MA20_07800	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_1742478_3	760568.Desku_2664	1.575e-86	299.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD3_k127_1742478_4	264198.Reut_A2355	1.588e-44	169.0	COG2059@1|root,COG2059@2|Bacteria,1MZHQ@1224|Proteobacteria,2WFNW@28216|Betaproteobacteria,1KFZS@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_1742478_6	159450.NH14_22120	7.199e-38	157.0	COG2059@1|root,COG2059@2|Bacteria,1RB6A@1224|Proteobacteria,2WFNT@28216|Betaproteobacteria,1KI4A@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_1742478_5	1267535.KB906767_gene3397	7.38e-43	160.0	COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria,2JJVU@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1742478_1	1382359.JIAL01000001_gene657	1.761e-224	698.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD3_k127_1742478_7	1267535.KB906767_gene4247	1.475e-37	142.0	COG3795@1|root,COG3795@2|Bacteria,3Y5F1@57723|Acidobacteria,2JN7W@204432|Acidobacteriia	204432|Acidobacteriia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD3_k127_1742773_4	56780.SYN_00797	1.099e-123	410.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,2MQCJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	MiaB-like tRNA modifying enzyme	mtaB	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HFD3_k127_1742773_6	717231.Flexsi_2108	9.137e-78	268.0	COG1045@1|root,COG1045@2|Bacteria,2GEVH@200930|Deferribacteres	200930|Deferribacteres	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HFD3_k127_1742773_0	269799.Gmet_1879	2.315e-212	671.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,43TBU@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD3_k127_1742773_2	1232410.KI421415_gene3029	1.418e-156	503.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,43U9Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	PFAM aspartate glutamate uridylate kinase	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HFD3_k127_1742773_7	1121423.JONT01000006_gene2409	2.538e-32	132.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised P-loop hydrolase UPF0079	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD3_k127_1742773_3	269799.Gmet_1883	4.213e-128	427.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,43T92@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HFD3_k127_1742773_5	1397528.Q671_16380	2.905e-82	280.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XHGB@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HFD3_k127_1742773_1	1125863.JAFN01000001_gene2159	3.339e-176	565.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD3_k127_1743436_2	1196322.A370_02987	5.028e-17	90.0	COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,24D4Q@186801|Clostridia	186801|Clostridia	P	TIGRFAM ABC transporter, substrate-binding protein, aliphatic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,OmpA
HFD3_k127_1743436_0	935840.JAEQ01000004_gene642	1.359e-204	657.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,43I9H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_1743436_1	935840.JAEQ01000004_gene641	2.713e-84	292.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,43HM4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_1752196_0	105559.Nwat_1493	2.334e-84	297.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales	135613|Chromatiales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
HFD3_k127_1752196_1	1254432.SCE1572_36760	1.483e-29	121.0	COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,42TYD@68525|delta/epsilon subdivisions,2WQSG@28221|Deltaproteobacteria,2Z1C9@29|Myxococcales	28221|Deltaproteobacteria	JK	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HFD3_k127_1752196_2	161528.ED21_26708	1.506e-05	49.0	28Z3Z@1|root,2ZKWE@2|Bacteria,1P6X6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1762349_5	644966.Tmar_R0053	2.261e-18	89.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3WD6Q@538999|Clostridiales incertae sedis	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD3_k127_1762349_0	671143.DAMO_3033	2.54e-142	460.0	COG0407@1|root,COG1587@1|root,COG0407@2|Bacteria,COG1587@2|Bacteria,2NP39@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,4.1.1.37,4.2.1.75	ko:K01599,ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194,R03197,R04972	RC00003,RC00871,RC00872,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	HEM4,Trans_reg_C,URO-D
HFD3_k127_1762349_2	671143.DAMO_3034	1.777e-87	299.0	COG0276@1|root,COG0276@2|Bacteria,2NQ0V@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD3_k127_1762349_1	671143.DAMO_3035	2.374e-131	435.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	hemG	-	1.14.19.9,1.3.3.15,1.3.3.4	ko:K00231,ko:K14266	ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130	M00121,M00789,M00790	R03222,R04178,R09570	RC00885,RC00949	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
HFD3_k127_1762349_3	1205680.CAKO01000007_gene4355	4.09e-87	297.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_1762349_4	1183438.GKIL_0378	1.365e-21	103.0	COG0412@1|root,COG0412@2|Bacteria,1FZX6@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_1762349_6	1424334.W822_11565	1.358e-12	70.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,3T66F@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_1766979_8	1231391.AMZF01000014_gene2432	2.223e-11	75.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1766979_7	1521187.JPIM01000019_gene372	1.951e-55	210.0	COG0477@1|root,COG2814@2|Bacteria,2GBHK@200795|Chloroflexi,376GU@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_1766979_5	292459.STH2818	6.876e-79	278.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HFD3_k127_1766979_4	582744.Msip34_2415	4.536e-81	271.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2W271@28216|Betaproteobacteria,2KMMP@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD3_k127_1766979_2	1340434.AXVA01000012_gene2953	3.202e-112	381.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,4HBJ1@91061|Bacilli	91061|Bacilli	C	Conserved carboxylase domain	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_1766979_6	1278073.MYSTI_02963	5.755e-64	227.0	COG0406@1|root,COG0406@2|Bacteria,1QNKS@1224|Proteobacteria,434AH@68525|delta/epsilon subdivisions,2WYK2@28221|Deltaproteobacteria,2Z1NH@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD3_k127_1766979_1	637389.Acaty_c1284	1.155e-209	662.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,2NCA6@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C
HFD3_k127_1766979_0	1232410.KI421424_gene1679	2.555e-220	692.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43RY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HFD3_k127_1766979_9	42256.RradSPS_1053	6.39e-05	48.0	COG2331@1|root,COG2331@2|Bacteria,2HGE7@201174|Actinobacteria,4CQV7@84995|Rubrobacteria	84995|Rubrobacteria	S	Regulatory protein, FmdB	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD3_k127_1766979_3	247490.KSU1_C1352	7.523e-111	375.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_1771815_0	1144310.PMI07_006194	1.194e-128	429.0	COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,2TRSE@28211|Alphaproteobacteria,4BDNH@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD3_k127_1771815_1	67315.JOBD01000002_gene2635	8.437e-71	250.0	COG2159@1|root,COG2159@2|Bacteria,2GP75@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
HFD3_k127_1771815_4	401526.TcarDRAFT_2525	1.628e-13	81.0	COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,4H5P0@909932|Negativicutes	909932|Negativicutes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_1771815_2	640081.Dsui_2122	6.656e-21	105.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2WEG1@28216|Betaproteobacteria,2KVYA@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_1771815_3	1424334.W822_07390	1.385e-14	85.0	COG0715@1|root,COG0715@2|Bacteria,1MVUJ@1224|Proteobacteria,2W9A2@28216|Betaproteobacteria,3T6BS@506|Alcaligenaceae	28216|Betaproteobacteria	P	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1771815_5	1048834.TC41_1829	4.41e-05	51.0	COG3435@1|root,COG3435@2|Bacteria,1UYG0@1239|Firmicutes,4HCWV@91061|Bacilli	91061|Bacilli	Q	Cupin domain	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD3_k127_1782472_2	113395.AXAI01000026_gene1887	7.077e-55	203.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
HFD3_k127_1782472_3	420324.KI912071_gene8169	1.226e-47	183.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,1JUDJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1782472_6	522772.Dacet_0267	9.212e-05	50.0	COG1484@1|root,COG1484@2|Bacteria,2GFU3@200930|Deferribacteres	2|Bacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HFD3_k127_1782472_1	748658.KB907313_gene2241	3.642e-61	224.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HFD3_k127_1782472_4	269799.Gmet_1587	5.564e-28	116.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42U0Y@68525|delta/epsilon subdivisions,2WR00@28221|Deltaproteobacteria,43V4Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HFD3_k127_1782472_5	868864.Dester_0239	3.964e-20	93.0	COG1550@1|root,COG1550@2|Bacteria,2G47V@200783|Aquificae	200783|Aquificae	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HFD3_k127_1782472_0	1232410.KI421413_gene517	4.483e-140	453.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43RX8@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Translation-initiation factor 2	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HFD3_k127_1786391_2	1201288.M900_0213	4.234e-17	82.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2MTCR@213481|Bdellovibrionales,2WRQ6@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD3_k127_1786391_0	1231391.AMZF01000046_gene961	1.453e-47	184.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_1786391_1	298653.Franean1_3135	2.2e-39	157.0	COG1024@1|root,COG1024@2|Bacteria,2H793@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_1800594_9	1121403.AUCV01000022_gene3529	7.728e-28	124.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria,2MKZK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_1800594_12	1206729.BAFZ01000025_gene541	4.761e-07	55.0	COG1872@1|root,COG1872@2|Bacteria,2GRF6@201174|Actinobacteria,4G34J@85025|Nocardiaceae	201174|Actinobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HFD3_k127_1800594_8	1122915.AUGY01000118_gene6532	1.096e-34	148.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575,ko:K08223	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.35,2.A.1.8	-	-	MFS_1
HFD3_k127_1800594_4	1121918.ARWE01000001_gene633	5.805e-94	325.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,43T5C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD3_k127_1800594_5	1232410.KI421422_gene2079	7.581e-83	282.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,43S4Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD3_k127_1800594_3	309801.trd_1791	6.828e-111	370.0	COG1092@1|root,COG1092@2|Bacteria,2G5YR@200795|Chloroflexi	200795|Chloroflexi	J	SMART PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HFD3_k127_1800594_6	370438.PTH_2609	2.42e-60	212.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,261ZC@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HFD3_k127_1800594_2	671143.DAMO_1612	1.072e-123	404.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K03671,ko:K22345	ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418	-	R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913,iPC815.YPO1374	Pyr_redox_2
HFD3_k127_1800594_7	671143.DAMO_0679	6.706e-54	191.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HFD3_k127_1800594_10	1396141.BATP01000054_gene2891	1.046e-17	89.0	2AX2R@1|root,31P12@2|Bacteria,46WJT@74201|Verrucomicrobia,2IWCE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
HFD3_k127_1800594_1	234267.Acid_7336	3.119e-136	451.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD3_k127_1800594_0	204669.Acid345_1270	1.012e-254	794.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HFD3_k127_1800594_11	204669.Acid345_1269	2.313e-09	58.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD3_k127_1818088_5	69279.BG36_06490	6.295e-45	180.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43J3W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD3_k127_1818088_0	502025.Hoch_0230	1.196e-107	360.0	COG0714@1|root,COG0714@2|Bacteria,1QE6X@1224|Proteobacteria,42ZU7@68525|delta/epsilon subdivisions,2X397@28221|Deltaproteobacteria,2YUWS@29|Myxococcales	28221|Deltaproteobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
HFD3_k127_1818088_4	502025.Hoch_0231	2.631e-66	246.0	COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,42Z19@68525|delta/epsilon subdivisions,2WZHK@28221|Deltaproteobacteria,2Z261@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HFD3_k127_1818088_3	123899.JPQP01000018_gene72	1.008e-72	253.0	COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,2WEIF@28216|Betaproteobacteria,3T2CS@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_1818088_2	1089548.KI783301_gene630	1.858e-77	273.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4HEYX@91061|Bacilli	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_1818088_1	1089548.KI783301_gene629	3.251e-80	274.0	COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,4HCK6@91061|Bacilli	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
HFD3_k127_1827113_2	439235.Dalk_3324	5.479e-132	429.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MID1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH family protein	phoH2	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HFD3_k127_1827113_4	909663.KI867149_gene3216	1.616e-49	180.0	COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD3_k127_1827113_0	338963.Pcar_2408	8.09e-289	911.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,43THC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD3_k127_1827113_8	479434.Sthe_1432	2.084e-16	85.0	COG2137@1|root,COG2137@2|Bacteria,2G6WA@200795|Chloroflexi,27YM4@189775|Thermomicrobia	189775|Thermomicrobia	S	RecX family	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HFD3_k127_1827113_1	404589.Anae109_0456	9.056e-164	522.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YTSX@29|Myxococcales	28221|Deltaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD3_k127_1827113_6	1379698.RBG1_1C00001G1887	6.93e-32	132.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HFD3_k127_1827113_3	671143.DAMO_2618	1.022e-86	304.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2NP0G@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CinA family	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HFD3_k127_1827113_7	879212.DespoDRAFT_03160	7.084e-24	107.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195	PgpA
HFD3_k127_1827113_5	1184267.A11Q_1218	1.205e-39	151.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2MTTF@213481|Bdellovibrionales,2WIYR@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD3_k127_1828726_4	443152.MDG893_15295	2.079e-62	230.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1828726_3	314278.NB231_08798	2e-83	292.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,1RN07@1236|Gammaproteobacteria,1X0B8@135613|Chromatiales	135613|Chromatiales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_2
HFD3_k127_1828726_9	330214.NIDE2776	3.44e-45	171.0	COG0604@1|root,COG0604@2|Bacteria,3J13T@40117|Nitrospirae	40117|Nitrospirae	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_1828726_11	1223521.BBJX01000019_gene609	8.396e-38	147.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,4ACYX@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_1828726_5	566461.SSFG_07829	5.301e-57	211.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_1828726_13	1206731.BAGB01000166_gene850	4.921e-34	136.0	COG2030@1|root,COG2030@2|Bacteria,2IEVN@201174|Actinobacteria	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HFD3_k127_1828726_0	671143.DAMO_3030	3.124e-145	470.0	COG1804@1|root,COG1804@2|Bacteria,2NQGI@2323|unclassified Bacteria	2|Bacteria	C	CoA-transferase family III	caiB	GO:0003674,GO:0003824,GO:0008410,GO:0016740,GO:0016782,GO:0047369	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD3_k127_1828726_18	1121456.ATVA01000013_gene1117	5.604e-07	58.0	COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,42WA7@68525|delta/epsilon subdivisions,2WRWX@28221|Deltaproteobacteria,2MCC2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_1828726_2	1382304.JNIL01000001_gene2406	9.095e-90	317.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli	91061|Bacilli	EH	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_1828726_14	1463857.JOFZ01000007_gene160	9.793e-31	134.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1828726_12	1173263.Syn7502_03004	7.877e-36	149.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1828726_15	1118054.CAGW01000075_gene3261	4.318e-29	130.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1828726_6	485913.Krac_1276	6.733e-57	208.0	COG2159@1|root,COG2159@2|Bacteria,2G8DN@200795|Chloroflexi	200795|Chloroflexi	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_1828726_20	77635.BISU_0634	0.0004721	51.0	COG0715@1|root,COG0715@2|Bacteria,2IHFG@201174|Actinobacteria,4D21Y@85004|Bifidobacteriales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1828726_1	1532557.JL37_16745	3.103e-119	396.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2W1IE@28216|Betaproteobacteria,3T1DH@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_1828726_7	1123261.AXDW01000022_gene232	1.608e-49	188.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,1S0NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_1828726_19	1205680.CAKO01000002_gene2759	1.579e-06	59.0	COG0715@1|root,COG0715@2|Bacteria,1QSRN@1224|Proteobacteria	1224|Proteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1828726_8	562970.Btus_0865	2.065e-47	181.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,27967@186823|Alicyclobacillaceae	91061|Bacilli	M	Male sterility protein	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HFD3_k127_1828726_17	648996.Theam_1728	2.389e-14	84.0	2EHRW@1|root,33BHM@2|Bacteria,2G4NJ@200783|Aquificae	200783|Aquificae	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HFD3_k127_1828726_16	429009.Adeg_0532	4.803e-19	91.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_1848993_9	237368.SCABRO_00651	4.271e-51	186.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
HFD3_k127_1848993_7	330214.NIDE3580	4.119e-98	325.0	COG1028@1|root,COG1028@2|Bacteria	330214.NIDE3580|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
HFD3_k127_1848993_10	671143.DAMO_2130	1.013e-47	175.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HFD3_k127_1848993_2	909663.KI867150_gene247	2.201e-158	511.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MQ96@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HFD3_k127_1848993_0	306281.AJLK01000098_gene3954	8.312e-226	710.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,1JHXE@1189|Stigonemataceae	1117|Cyanobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD3_k127_1848993_8	443152.MDG893_15295	2.616e-53	200.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1848993_3	443152.MDG893_15387	7.599e-148	491.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria,469ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_1848993_1	1476876.JOJO01000036_gene4375	1.792e-208	676.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_1848993_5	240015.ACP_2222	6.865e-131	430.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HFD3_k127_1848993_11	864702.OsccyDRAFT_2543	1.233e-23	107.0	COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria,1HBXB@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_1848993_6	671143.DAMO_0004	4.696e-112	379.0	COG0612@1|root,COG0612@2|Bacteria,2NPE5@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_1848993_4	671143.DAMO_0005	3.635e-143	464.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_1853099_9	290397.Adeh_3327	1.808e-22	98.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,42VH9@68525|delta/epsilon subdivisions,2WT3R@28221|Deltaproteobacteria,2YVNR@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD3_k127_1853099_3	706587.Desti_2694	1.633e-134	437.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
HFD3_k127_1853099_1	671143.DAMO_2859	5.214e-207	653.0	COG0312@1|root,COG0312@2|Bacteria,2NNWH@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD3_k127_1853099_2	330214.NIDE1515	1.125e-170	548.0	COG0312@1|root,COG0312@2|Bacteria,3J0P7@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD3_k127_1853099_10	1293047.CBMA010000052_gene3265	3.05e-19	98.0	COG0697@1|root,arCOG00272@2157|Archaea,2XVSM@28890|Euryarchaeota,23S7J@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_1853099_8	1122915.AUGY01000020_gene6479	6.089e-29	129.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1853099_7	555779.Dthio_PD0504	9.932e-32	126.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338
HFD3_k127_1853099_11	760117.JN27_23175	8.635e-12	67.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,4739T@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_1853099_5	645991.Sgly_3094	2.61e-50	197.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,2610Z@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_1853099_6	1163617.SCD_n02362	1.938e-34	139.0	29V5H@1|root,30GJ5@2|Bacteria,1PHC8@1224|Proteobacteria,2VRT9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3617)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3617
HFD3_k127_1853099_4	986075.CathTA2_3069	5.42e-122	401.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4HAGM@91061|Bacilli	91061|Bacilli	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HFD3_k127_1853099_0	234267.Acid_0587	1.247e-232	736.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,3Y4RT@57723|Acidobacteria	57723|Acidobacteria	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase,MFS_1
HFD3_k127_1858142_8	663610.JQKO01000015_gene1908	5.204e-81	275.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,3N9KG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
HFD3_k127_1858142_11	485913.Krac_12550	1.462e-71	252.0	COG1235@1|root,COG1235@2|Bacteria,2G833@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD3_k127_1858142_13	189753.AXAS01000030_gene7102	5.14e-35	146.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1858142_3	1122917.KB899671_gene4389	1.273e-96	348.0	COG0471@1|root,COG0664@1|root,COG0471@2|Bacteria,COG0664@2|Bacteria,1U26G@1239|Firmicutes,4HEVG@91061|Bacilli	91061|Bacilli	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp,cNMP_binding
HFD3_k127_1858142_14	323848.Nmul_A1698	1.296e-26	113.0	COG0671@1|root,COG0671@2|Bacteria,1MWK1@1224|Proteobacteria,2VQZZ@28216|Betaproteobacteria,372WW@32003|Nitrosomonadales	28216|Betaproteobacteria	I	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD3_k127_1858142_10	1173026.Glo7428_2073	9.638e-79	273.0	COG2931@1|root,COG2931@2|Bacteria,1GB2M@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1858142_0	443143.GM18_1249	1.884e-155	504.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_1858142_9	443143.GM18_1250	4.961e-79	290.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZV@68525|delta/epsilon subdivisions,2WMI3@28221|Deltaproteobacteria,43VZB@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,SBP_bac_3
HFD3_k127_1858142_4	1041146.ATZB01000007_gene2874	1.206e-94	323.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,4B8DR@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C,Haem_bd
HFD3_k127_1858142_16	189753.AXAS01000041_gene2534	2.073e-16	80.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1858142_18	1379270.AUXF01000007_gene972	6.891e-09	64.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	AhpC-TSA,Redoxin
HFD3_k127_1858142_21	1247963.JPHU01000008_gene2890	0.0001752	49.0	COG3409@1|root,COG3409@2|Bacteria,1ND4S@1224|Proteobacteria,2UJRX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD3_k127_1858142_19	323261.Noc_A0011	1.051e-07	57.0	29UFS@1|root,30FSN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1858142_1	706587.Desti_4134	9.635e-151	491.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
HFD3_k127_1858142_7	189753.AXAS01000041_gene2534	3.286e-86	296.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1858142_2	224911.27352026	9.615e-147	484.0	COG1018@1|root,COG2258@1|root,COG1018@2|Bacteria,COG2258@2|Bacteria,1MV41@1224|Proteobacteria,2TQXP@28211|Alphaproteobacteria,3JVF5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Oxidoreductase NAD-binding domain	-	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	3-alpha,FAD_binding_6,Fer2,MOSC,NAD_binding_1,Putative_PNPOx
HFD3_k127_1858142_12	1210884.HG799474_gene15155	6.212e-69	247.0	COG3576@1|root,COG3576@2|Bacteria,2IXAK@203682|Planctomycetes	203682|Planctomycetes	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD3_k127_1858142_15	1502850.FG91_01971	3.061e-21	106.0	COG0655@1|root,COG0655@2|Bacteria,1RDPF@1224|Proteobacteria,2UNC7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HFD3_k127_1858142_6	189753.AXAS01000041_gene2534	1.015e-86	297.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_1858142_20	1499968.TCA2_5335	1.204e-06	51.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HRQH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1858142_5	1242864.D187_005267	1.095e-92	314.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,42SG1@68525|delta/epsilon subdivisions,2WP1E@28221|Deltaproteobacteria,2YUU8@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HFD3_k127_1858142_17	56780.SYN_02280	8.643e-14	79.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,43B7B@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
HFD3_k127_1927891_7	574087.Acear_1443	4.039e-11	65.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HFD3_k127_1927891_5	880072.Desac_1165	2.347e-50	184.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2WP25@28221|Deltaproteobacteria,2MS0D@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD3_k127_1927891_3	330214.NIDE0395	1.755e-90	307.0	COG0223@1|root,COG0223@2|Bacteria,3J0GW@40117|Nitrospirae	40117|Nitrospirae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HFD3_k127_1927891_1	1121468.AUBR01000005_gene33	5.518e-122	406.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42EKD@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HFD3_k127_1927891_4	269799.Gmet_0067	3.697e-76	261.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD3_k127_1927891_2	404589.Anae109_1511	4.694e-102	348.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2Z11I@29|Myxococcales	28221|Deltaproteobacteria	M	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HFD3_k127_1927891_0	290397.Adeh_0789	4.014e-307	957.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2YUIP@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD3_k127_1927891_6	1297742.A176_05580	1.459e-33	131.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2YVP9@29|Myxococcales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD3_k127_1938086_4	913325.N799_02795	1.72e-12	68.0	2CBKC@1|root,32RTJ@2|Bacteria,1N5I0@1224|Proteobacteria,1SACI@1236|Gammaproteobacteria,1X74V@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1938086_1	404380.Gbem_1452	6.001e-118	390.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Acyl-CoA dehydrogenase	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_1938086_0	1380394.JADL01000017_gene522	3.986e-118	391.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,2JPUP@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_1938086_2	485913.Krac_2148	9.858e-64	228.0	COG1028@1|root,COG1028@2|Bacteria,2G8CF@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD3_k127_1938086_3	573370.DMR_29410	1.737e-59	220.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_1939229_6	1303518.CCALI_00699	8.272e-06	57.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HFD3_k127_1939229_3	880072.Desac_2382	5.417e-123	404.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	Sodium calcium exchanger membrane	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HFD3_k127_1939229_5	335543.Sfum_1459	1.87e-30	130.0	COG1226@1|root,32Y28@2|Bacteria,1PVKD@1224|Proteobacteria,4379F@68525|delta/epsilon subdivisions,2X2D3@28221|Deltaproteobacteria,2MSI0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HFD3_k127_1939229_4	485913.Krac_9228	1.066e-66	239.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HFD3_k127_1939229_1	204669.Acid345_0452	1.22e-163	528.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	204432|Acidobacteriia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD3_k127_1939229_0	671143.DAMO_0621	0.0	1157.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HFD3_k127_1939229_2	1121875.KB907549_gene1996	2.023e-151	483.0	COG1063@1|root,COG1063@2|Bacteria,4P3W3@976|Bacteroidetes	976|Bacteroidetes	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HFD3_k127_1946194_5	868864.Dester_1525	2.327e-45	170.0	COG1189@1|root,COG1189@2|Bacteria,2G3MN@200783|Aquificae	200783|Aquificae	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD3_k127_1946194_0	398767.Glov_2235	3.279e-222	714.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HFD3_k127_1946194_3	243231.GSU1765	8.378e-86	294.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,43UK9@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD3_k127_1946194_8	1278073.MYSTI_07029	4.438e-14	81.0	28UXW@1|root,2ZH1P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_1946194_4	1380394.JADL01000002_gene1095	1.383e-82	285.0	COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria,2JRNF@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_1946194_2	266117.Rxyl_0504	2.382e-111	372.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4CSCW@84995|Rubrobacteria	84995|Rubrobacteria	G	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD3_k127_1946194_1	886293.Sinac_7530	2.375e-158	514.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_1946194_9	593117.TGAM_1415	1.363e-10	72.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
HFD3_k127_1946194_7	68570.DC74_988	6.148e-26	114.0	2BCA3@1|root,325V8@2|Bacteria,2HB4V@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD3_k127_1946194_6	313606.M23134_04296	4.186e-26	117.0	28J0S@1|root,2Z8XX@2|Bacteria,4P2J4@976|Bacteroidetes,47X8E@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_195690_13	1415630.U771_13790	3.422e-07	58.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1SYKI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcription factor	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_195690_3	247490.KSU1_B0440	5.392e-58	205.0	2AVTU@1|root,31MME@2|Bacteria,2J2ZG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_195690_12	909663.KI867150_gene2362	1.415e-09	61.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MRP5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD3_k127_195690_8	1123288.SOV_1c07060	2.389e-20	92.0	COG2391@1|root,COG2391@2|Bacteria,1VJEX@1239|Firmicutes,4H6AR@909932|Negativicutes	909932|Negativicutes	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
HFD3_k127_195690_4	395963.Bind_1925	1.067e-39	153.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3NBKA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_195690_0	264198.Reut_A1185	2.988e-292	919.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria,1KGKU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	E1-E2 ATPase	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD3_k127_195690_9	177437.HRM2_39180	4.286e-19	93.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2X5CQ@28221|Deltaproteobacteria,2MJF5@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_195690_2	1121403.AUCV01000032_gene2875	3.128e-78	281.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2WIM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
HFD3_k127_195690_7	1121441.AUCX01000003_gene2974	1.398e-20	104.0	COG1271@1|root,COG1271@2|Bacteria,1QXQF@1224|Proteobacteria,42NKJ@68525|delta/epsilon subdivisions,2WKHM@28221|Deltaproteobacteria,2M95S@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	oxidase subunit	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	-
HFD3_k127_195690_11	1346330.M472_10950	1.724e-14	74.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD3_k127_195690_6	945713.IALB_1656	1.948e-27	118.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD3_k127_195690_14	358681.BBR47_33360	7.434e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,1V6K2@1239|Firmicutes,4HJ55@91061|Bacilli,275HN@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_195690_10	478741.JAFS01000001_gene1968	3.536e-18	90.0	COG0394@1|root,COG0394@2|Bacteria,46V1H@74201|Verrucomicrobia,37GZV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HFD3_k127_195690_5	278963.ATWD01000001_gene2665	5.49e-35	138.0	COG0640@1|root,COG0640@2|Bacteria,3Y7J1@57723|Acidobacteria,2JMRU@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HFD3_k127_195690_16	1210884.HG799462_gene9129	0.0001614	44.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD3_k127_195690_1	357808.RoseRS_1917	1.812e-166	530.0	COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia	32061|Chloroflexia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HFD3_k127_1996736_22	562970.Btus_2323	3.421e-17	87.0	COG0179@1|root,COG0179@2|Bacteria,1TUD1@1239|Firmicutes,4HU05@91061|Bacilli,278VY@186823|Alicyclobacillaceae	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_1996736_10	257310.BB0389	1.05e-46	181.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2VMW1@28216|Betaproteobacteria,3T349@506|Alcaligenaceae	28216|Betaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_1996736_21	1123367.C666_14365	2.351e-17	94.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2WEG1@28216|Betaproteobacteria,2KVYA@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_1996736_3	1118054.CAGW01000061_gene2409	9.62e-118	391.0	COG3135@1|root,COG3135@2|Bacteria,1UFIU@1239|Firmicutes,4HE6P@91061|Bacilli,26TTT@186822|Paenibacillaceae	91061|Bacilli	Q	Benzoate membrane transport protein	-	-	-	ko:K05782	-	-	-	-	ko00000,ko02000	2.A.46.1	-	-	BenE
HFD3_k127_1996736_28	686340.Metal_0931	0.0006958	50.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XFQY@135618|Methylococcales	135618|Methylococcales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD3_k127_1996736_1	1499967.BAYZ01000103_gene3741	9.367e-174	563.0	COG1032@1|root,COG1032@2|Bacteria,2NQ35@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
HFD3_k127_1996736_14	1123368.AUIS01000030_gene1253	5.789e-32	127.0	COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,1SE9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HFD3_k127_1996736_12	70601.3257399	3.62e-41	160.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	28890|Euryarchaeota	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_1996736_4	1123072.AUDH01000002_gene2353	1.095e-111	376.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine synthase	MA20_07800	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_1996736_8	1033734.CAET01000041_gene402	7.374e-55	207.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,1ZHB1@1386|Bacillus	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_1996736_24	743719.PaelaDRAFT_0962	2.306e-15	88.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_1996736_20	1539298.JO41_06005	6.697e-19	91.0	COG5496@1|root,COG5496@2|Bacteria,2J7EU@203691|Spirochaetes	203691|Spirochaetes	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD3_k127_1996736_6	640081.Dsui_2768	8.382e-84	291.0	COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales	206389|Rhodocyclales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HFD3_k127_1996736_0	240015.ACP_0733	2.026e-194	620.0	COG2759@1|root,COG2759@2|Bacteria,3Y338@57723|Acidobacteria,2JMF8@204432|Acidobacteriia	204432|Acidobacteriia	H	Formate--tetrahydrofolate ligase	-	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HFD3_k127_1996736_26	426716.JOAJ01000001_gene844	4.14e-10	71.0	COG0715@1|root,COG0715@2|Bacteria,2HHNY@201174|Actinobacteria,4FZGF@85025|Nocardiaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_1996736_5	1128421.JAGA01000004_gene2558	2.427e-109	368.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_1996736_19	396588.Tgr7_0278	2.602e-21	102.0	COG1833@1|root,COG1833@2|Bacteria,1N8Y1@1224|Proteobacteria,1SDIB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
HFD3_k127_1996736_7	479434.Sthe_0270	7.187e-59	218.0	COG2070@1|root,COG2070@2|Bacteria,2G8J2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HFD3_k127_1996736_9	1500257.JQNM01000014_gene2939	1.21e-52	199.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,2UI7P@28211|Alphaproteobacteria,4BMG3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_1996736_11	1231391.AMZF01000068_gene2179	4.892e-42	169.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_1996736_18	880072.Desac_1068	2.831e-23	101.0	COG2336@1|root,COG2336@2|Bacteria,1N7YN@1224|Proteobacteria,42VFV@68525|delta/epsilon subdivisions,2WRSX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SpoVT / AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HFD3_k127_1996736_13	1496688.ER33_11565	7.271e-40	150.0	COG2337@1|root,COG2337@2|Bacteria,1G6KE@1117|Cyanobacteria,22T6U@167375|Cyanobium	1117|Cyanobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD3_k127_1996736_2	1267533.KB906734_gene3765	3.259e-152	488.0	COG2040@1|root,COG2040@2|Bacteria	2|Bacteria	E	homocysteine	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HFD3_k127_1996736_17	497964.CfE428DRAFT_3349	1.147e-23	102.0	293G7@1|root,2ZQYH@2|Bacteria,46WT2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
HFD3_k127_1996736_27	1499684.CCNP01000025_gene3479	2.09e-07	61.0	COG2865@1|root,COG2865@2|Bacteria,1UZZK@1239|Firmicutes,25CHX@186801|Clostridia,36EY6@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
HFD3_k127_1996736_15	658088.HMPREF0987_00625	5.432e-31	127.0	28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,27M5D@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Glycine/sarcosine/betaine reductase component B subunits	grdE	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
HFD3_k127_200328_7	1112214.AHIS01000051_gene2457	1.661e-05	47.0	COG0500@1|root,COG2226@2|Bacteria,1RFR5@1224|Proteobacteria,2U7RB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD3_k127_200328_0	36331.EPrPI00000017145	1.886e-92	315.0	COG1304@1|root,KOG0538@2759|Eukaryota,1MD1U@121069|Pythiales	121069|Pythiales	C	Peroxisomal (S)-2-hydroxy-acid oxidase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
HFD3_k127_200328_1	583355.Caka_1911	5.008e-51	198.0	COG3267@1|root,COG3267@2|Bacteria,46SXM@74201|Verrucomicrobia,3K91Q@414999|Opitutae	414999|Opitutae	U	Pfam:Arch_ATPase	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
HFD3_k127_200328_4	1121441.AUCX01000007_gene1165	9.691e-11	72.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MHIP@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HFD3_k127_200328_3	1126627.BAWE01000005_gene5813	2.128e-15	89.0	COG0715@1|root,COG0715@2|Bacteria,1RDER@1224|Proteobacteria,2U7WN@28211|Alphaproteobacteria,3K12H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_200328_6	203119.Cthe_2489	2.05e-08	66.0	COG1652@1|root,COG1652@2|Bacteria,1V8VD@1239|Firmicutes,25EET@186801|Clostridia,3WS2M@541000|Ruminococcaceae	186801|Clostridia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HFD3_k127_200328_5	1240349.ANGC01000004_gene1913	2.572e-10	68.0	COG2141@1|root,COG2267@1|root,COG2141@2|Bacteria,COG2267@2|Bacteria,2GKP1@201174|Actinobacteria,4FW3Q@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_200328_2	1547437.LL06_00335	1.614e-30	127.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,43IZ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_2013588_15	1122971.BAME01000013_gene1635	6.18e-07	51.0	COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,2FMM6@200643|Bacteroidia,22VY8@171551|Porphyromonadaceae	976|Bacteroidetes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573,ko:K12585	ko03018,map03018	M00391	-	-	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD3_k127_2013588_1	883078.HMPREF9695_01449	1.572e-173	557.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3JTUJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PBP
HFD3_k127_2013588_7	1038859.AXAU01000002_gene577	2.154e-56	207.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2TSFV@28211|Alphaproteobacteria,3JRG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_2013588_12	1307759.JOMJ01000003_gene2163	2.206e-17	90.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD3_k127_2013588_8	1242864.D187_008877	1.045e-36	149.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD3_k127_2013588_4	479434.Sthe_3388	4.105e-83	280.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2G62W@200795|Chloroflexi,27YXY@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2013588_0	479434.Sthe_3388	0.0	1282.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2G62W@200795|Chloroflexi,27YXY@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2013588_2	1382356.JQMP01000001_gene1252	3.213e-125	406.0	COG0437@1|root,COG0437@2|Bacteria,2G9ZX@200795|Chloroflexi,27Y09@189775|Thermomicrobia	189775|Thermomicrobia	C	4Fe-4S binding domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3
HFD3_k127_2013588_3	479434.Sthe_3390	1.045e-87	299.0	COG3301@1|root,COG3301@2|Bacteria,2GA0G@200795|Chloroflexi,27YBQ@189775|Thermomicrobia	189775|Thermomicrobia	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD3_k127_2013588_6	479434.Sthe_3392	1.243e-65	235.0	COG3058@1|root,COG3058@2|Bacteria,2G9S5@200795|Chloroflexi,27YFM@189775|Thermomicrobia	189775|Thermomicrobia	O	Protein involved in formate dehydrogenase formation	-	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
HFD3_k127_2013588_10	1192034.CAP_3490	1.296e-26	113.0	29EH1@1|root,336FM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2013588_16	1198452.Jab_2c08280	0.0001812	47.0	COG0457@1|root,COG0457@2|Bacteria,1RIHH@1224|Proteobacteria,2VTBB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2
HFD3_k127_2013588_11	290397.Adeh_2583	5.522e-22	101.0	COG1959@1|root,COG1959@2|Bacteria,1Q19C@1224|Proteobacteria,4375I@68525|delta/epsilon subdivisions,2WRDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD3_k127_2013588_5	404589.Anae109_1288	1.093e-74	254.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2Z08H@29|Myxococcales	28221|Deltaproteobacteria	C	Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD3_k127_2013588_9	1382306.JNIM01000001_gene1150	2.383e-35	136.0	COG1146@1|root,COG1146@2|Bacteria,2G75G@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
HFD3_k127_2013588_13	251221.35211934	1.713e-12	70.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria	1117|Cyanobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD3_k127_2016106_4	697282.Mettu_3435	2.5e-05	48.0	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,1S2A0@1236|Gammaproteobacteria,1XGC6@135618|Methylococcales	135618|Methylococcales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_2016106_3	485913.Krac_1243	8.919e-10	62.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ynjA	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
HFD3_k127_2016106_1	1007104.SUS17_2438	6.002e-79	277.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2TYHX@28211|Alphaproteobacteria,2K0ZW@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD3_k127_2016106_0	76114.ebA5622	3.209e-176	584.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_2016106_2	768710.DesyoDRAFT_0395	7.627e-64	229.0	COG1529@1|root,COG1529@2|Bacteria,1UYGE@1239|Firmicutes,24C0D@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	ndhM	-	1.17.1.5	ko:K20448	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C2
HFD3_k127_2017693_0	1510531.JQJJ01000015_gene3001	3.522e-180	573.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JX4Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_2017693_5	1510531.JQJJ01000015_gene3000	1.176e-26	114.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2U5KG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HFD3_k127_2017693_3	94624.Bpet2909	2.625e-85	293.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJ08@28216|Betaproteobacteria,3T5HZ@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2017693_1	396588.Tgr7_1472	2.199e-114	377.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria,1X2QZ@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_2017693_6	1173263.Syn7502_03004	9.62e-23	109.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2017693_4	330214.NIDE3764	7.279e-77	265.0	28PNA@1|root,2ZCB3@2|Bacteria	2|Bacteria	S	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD3_k127_2017693_2	1303518.CCALI_01700	7.472e-106	359.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HFD3_k127_2017693_8	871968.DESME_01970	1.017e-15	88.0	COG2267@1|root,COG2267@2|Bacteria,1V4GY@1239|Firmicutes,25EJZ@186801|Clostridia,261ST@186807|Peptococcaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_2017693_7	518766.Rmar_2009	5.728e-21	97.0	COG1959@1|root,COG1959@2|Bacteria,4NURI@976|Bacteroidetes,1FJGW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD3_k127_2028549_12	767817.Desgi_3875	7.6e-11	69.0	COG4647@1|root,COG4647@2|Bacteria	2|Bacteria	Q	ligase activity	apc2	-	6.4.1.6,6.4.1.8	ko:K10701,ko:K10856	ko00642,ko01120,ko01220,map00642,map01120,map01220	-	R05453	RC00040	ko00000,ko00001,ko01000	-	-	-	Acetone_carb_G
HFD3_k127_2028549_9	1028800.RG540_PA09280	6.271e-25	117.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2028549_11	743719.PaelaDRAFT_0962	4.642e-18	96.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2028549_1	189753.AXAS01000041_gene2534	3.841e-90	307.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_2028549_0	1231190.NA8A_14544	1.758e-101	344.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,43KJI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2028549_8	439235.Dalk_3386	2.427e-35	139.0	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,437V5@68525|delta/epsilon subdivisions,2X34N@28221|Deltaproteobacteria,2MNPW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HFD3_k127_2028549_10	1293048.CBMB010000005_gene2869	2.051e-24	116.0	COG0697@1|root,arCOG00272@2157|Archaea,2XVSM@28890|Euryarchaeota,23S7J@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_2028549_6	671143.DAMO_2973	4.231e-38	149.0	COG1047@1|root,COG1047@2|Bacteria,2NQ0G@2323|unclassified Bacteria	2|Bacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD3_k127_2028549_2	1037409.BJ6T_28900	7.999e-72	258.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_2028549_4	1370121.AUWS01000050_gene1472	1.045e-38	157.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,235A3@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD3_k127_2028549_5	671143.DAMO_2973	3.892e-38	150.0	COG1047@1|root,COG1047@2|Bacteria,2NQ0G@2323|unclassified Bacteria	2|Bacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HFD3_k127_2028549_3	56780.SYN_00042	5.543e-68	239.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42QVM@68525|delta/epsilon subdivisions,2WN3E@28221|Deltaproteobacteria,2MRIY@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sir2 family	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD3_k127_2028549_7	1316936.K678_01186	1.996e-35	141.0	COG3428@1|root,COG3428@2|Bacteria,1N9PB@1224|Proteobacteria,2TUD0@28211|Alphaproteobacteria,2JU7A@204441|Rhodospirillales	204441|Rhodospirillales	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HFD3_k127_2030769_7	1173263.Syn7502_03004	6.702e-11	68.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2030769_8	1232437.KL662057_gene3900	7.41e-11	73.0	COG3301@1|root,COG3301@2|Bacteria,1N6TR@1224|Proteobacteria	1224|Proteobacteria	P	DMSO reductase anchor subunit (DmsC)	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD3_k127_2030769_2	1232410.KI421423_gene1914	2.6e-69	240.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M6H@68525|delta/epsilon subdivisions,2X26P@28221|Deltaproteobacteria,43V6X@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
HFD3_k127_2030769_0	76114.ebA5622	3.246e-185	608.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_2030769_4	443152.MDG893_15295	2.678e-58	218.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2030769_3	1280689.AUJC01000011_gene1596	4.17e-63	235.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
HFD3_k127_2030769_6	240015.ACP_0764	3.981e-37	150.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD3_k127_2030769_1	266117.Rxyl_3133	2.516e-139	460.0	COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,4CS7R@84995|Rubrobacteria	84995|Rubrobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_2030769_5	1123257.AUFV01000008_gene517	6.345e-52	193.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria	1224|Proteobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HFD3_k127_20393_0	338966.Ppro_1172	5.789e-189	612.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,43TQ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HFD3_k127_20393_4	234267.Acid_6504	1.233e-09	72.0	COG2982@1|root,COG2982@2|Bacteria,3Y2J8@57723|Acidobacteria	57723|Acidobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD3_k127_20393_1	1157490.EL26_23155	2.913e-162	519.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,277YV@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	pcaF	-	2.3.1.174,2.3.1.223,2.3.1.9	ko:K00626,ko:K02615	ko00071,ko00072,ko00280,ko00310,ko00360,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00360,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R00829,R01177,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD3_k127_20393_3	1118054.CAGW01000061_gene2433	2.055e-60	217.0	COG1250@1|root,COG1250@2|Bacteria,1TSZI@1239|Firmicutes,4HBK3@91061|Bacilli,26UKH@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
HFD3_k127_20393_2	1120973.AQXL01000095_gene249	1.024e-86	293.0	COG1250@1|root,COG1250@2|Bacteria,1UUAQ@1239|Firmicutes,4HBSJ@91061|Bacilli	91061|Bacilli	I	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
HFD3_k127_2051405_0	1197906.CAJQ02000021_gene4595	1.811e-93	313.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,3JT9R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_2051405_3	1238182.C882_0307	2.374e-45	180.0	COG0642@1|root,COG0840@1|root,COG5002@1|root,COG0840@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales	204441|Rhodospirillales	T	transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,Response_reg
HFD3_k127_2051405_2	443152.MDG893_15085	1.973e-56	211.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2051405_1	1192034.CAP_6251	2.449e-68	245.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	1224|Proteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_2051405_4	1173025.GEI7407_2268	1.992e-09	60.0	COG0457@1|root,COG0457@2|Bacteria,1G5P9@1117|Cyanobacteria,1HB1F@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
HFD3_k127_2056554_2	926561.KB900617_gene1579	1.642e-53	204.0	COG1388@1|root,COG1785@1|root,COG1388@2|Bacteria,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,3WAZT@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
HFD3_k127_2056554_1	671143.DAMO_0834	9.44e-68	237.0	COG1183@1|root,COG1183@2|Bacteria,2NR1K@2323|unclassified Bacteria	2|Bacteria	I	phosphatidylcholine synthase activity	pcs	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24,2.7.8.8	ko:K01004,ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800,R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HFD3_k127_2056554_3	1502851.FG93_03963	1.615e-31	135.0	COG0625@1|root,COG0625@2|Bacteria,1RC4Y@1224|Proteobacteria,2U6JK@28211|Alphaproteobacteria,3JVU5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HFD3_k127_2056554_0	234267.Acid_1455	4.831e-115	393.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria	57723|Acidobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PDZ_2,Peptidase_M28
HFD3_k127_2056554_4	574375.BAGA_00655	1.198e-29	129.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
HFD3_k127_2068911_1	323097.Nham_3287	4.607e-129	440.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VF1V@28211|Alphaproteobacteria,3JQQ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
HFD3_k127_2068911_2	1382306.JNIM01000001_gene2693	7.913e-74	258.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_2068911_0	1408254.T458_21695	5.892e-188	616.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,26S7Z@186822|Paenibacillaceae	91061|Bacilli	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_2068911_3	525904.Tter_2234	5.244e-62	216.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	coxS	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_2068911_5	1056495.Calag_0125	1.358e-15	83.0	arCOG02998@1|root,arCOG02998@2157|Archaea	2157|Archaea	L	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_2068911_4	269482.Bcep1808_6383	3.144e-46	175.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2VV9X@28216|Betaproteobacteria,1K8N9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_2072662_9	420324.KI911972_gene3032	9.124e-15	75.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,1JYYS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
HFD3_k127_2072662_6	1121877.JQKF01000018_gene2547	4.754e-38	154.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4CN1R@84992|Acidimicrobiia	84992|Acidimicrobiia	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2072662_10	1519464.HY22_13865	1.422e-07	54.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD3_k127_2072662_7	986075.CathTA2_1857	7.086e-22	98.0	COG1225@1|root,COG1225@2|Bacteria,1V6MU@1239|Firmicutes,4HK8J@91061|Bacilli	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD3_k127_2072662_11	1201288.M900_2299	6.607e-06	51.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	GST_N_3,Glutaredoxin
HFD3_k127_2072662_1	1191523.MROS_0161	1.466e-159	513.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	lysJ	-	2.6.1.11,2.6.1.17	ko:K00821,ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Peptidase_M20
HFD3_k127_2072662_3	1191523.MROS_0162	4.983e-105	348.0	COG0548@1|root,COG0548@2|Bacteria	2|Bacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	lysZ	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8,3.5.1.16	ko:K00930,ko:K01438,ko:K05828,ko:K05831	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R00669,R02649,R09107,R09776,R09779,R10930,R10933	RC00002,RC00043,RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Peptidase_M20
HFD3_k127_2072662_4	1191523.MROS_0163	5.129e-78	266.0	COG0121@1|root,COG0121@2|Bacteria	2|Bacteria	S	cellular modified histidine biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HFD3_k127_2072662_0	1191523.MROS_0164	1.232e-162	518.0	COG0002@1|root,COG0002@2|Bacteria	2|Bacteria	E	N-acetyl-gamma-glutamyl-phosphate reductase activity	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD3_k127_2072662_2	1191523.MROS_0165	2.887e-140	449.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	lysX	-	6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43	ko:K05827,ko:K05844,ko:K14940,ko:K18310	ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230	M00031	R09401,R09775,R10677,R10678	RC00064,RC00090,RC00141,RC03233	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RimK
HFD3_k127_2072662_8	1128421.JAGA01000001_gene2378	7.081e-15	75.0	2DRHT@1|root,33BTG@2|Bacteria,2NRSJ@2323|unclassified Bacteria	2|Bacteria	S	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
HFD3_k127_2072662_5	1134413.ANNK01000127_gene2529	7.175e-74	255.0	COG0726@1|root,COG0726@2|Bacteria,1VA2Q@1239|Firmicutes,4HEX3@91061|Bacilli,1ZK98@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_2104889_0	1144310.PMI07_001945	2.125e-106	366.0	COG3836@1|root,COG3836@2|Bacteria,1R9U6@1224|Proteobacteria,2TSTY@28211|Alphaproteobacteria,4B7QE@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HFD3_k127_2104889_1	1230476.C207_00196	9.321e-95	321.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria,3JW6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_2104889_3	1121377.KB906419_gene3921	9.679e-09	57.0	COG1804@1|root,COG1804@2|Bacteria,1WIR7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_2104889_4	865937.Gilli_0747	4.306e-06	55.0	2DR29@1|root,339VD@2|Bacteria,4NZEP@976|Bacteroidetes,1I852@117743|Flavobacteriia,2P7SJ@244698|Gillisia	976|Bacteroidetes	S	SPTR Membrane or secreted protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2104889_2	512565.AMIS_57500	2.889e-72	259.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DCJE@85008|Micromonosporales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.20	ko:K07749,ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
HFD3_k127_213110_0	349161.Dred_1504	5.167e-65	237.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,263RX@186807|Peptococcaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_213110_1	1049564.TevJSym_ap00120	3.065e-37	142.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1J6NS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
HFD3_k127_213110_2	1230476.C207_05009	5.577e-10	70.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,3K1ZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2182467_5	1500257.JQNM01000014_gene2912	4.422e-18	88.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2182467_3	479434.Sthe_0539	1.098e-33	136.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,MaoC_dehydratas,OB_aCoA_assoc
HFD3_k127_2182467_0	1304878.AUGD01000017_gene1021	1.426e-92	317.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,3JX5E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N
HFD3_k127_2182467_2	1038860.AXAP01000097_gene5007	1.438e-36	151.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,3K1ZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2182467_4	1283287.KB822577_gene3349	3.834e-22	103.0	COG1335@1|root,COG1335@2|Bacteria,2I9AW@201174|Actinobacteria,4DSIT@85009|Propionibacteriales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_2182467_6	404380.Gbem_2532	1.105e-15	79.0	2DFV1@1|root,2ZT9B@2|Bacteria	2|Bacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
HFD3_k127_2182467_7	404380.Gbem_2532	5.062e-13	70.0	2DFV1@1|root,2ZT9B@2|Bacteria	2|Bacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
HFD3_k127_2182467_1	767817.Desgi_1120	2.005e-53	194.0	COG0437@1|root,COG0437@2|Bacteria,1V5RH@1239|Firmicutes,24IFS@186801|Clostridia,261VT@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
HFD3_k127_2182467_8	1121866.AUGK01000007_gene320	1.028e-09	62.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CX02@84998|Coriobacteriia	84998|Coriobacteriia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_2191531_9	935840.JAEQ01000004_gene646	3.052e-10	68.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2191531_5	1034347.CAHJ01000012_gene2392	9.726e-77	271.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	Redoxin,Thioredoxin_8
HFD3_k127_2191531_8	29540.C481_20731	1.049e-11	68.0	arCOG10135@1|root,arCOG10135@2157|Archaea,2XY9Z@28890|Euryarchaeota,23W2D@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2191531_11	29540.C481_20731	4.038e-06	52.0	arCOG10135@1|root,arCOG10135@2157|Archaea,2XY9Z@28890|Euryarchaeota,23W2D@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2191531_1	880072.Desac_2700	9.92e-151	490.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MQV1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
HFD3_k127_2191531_3	1089548.KI783301_gene2142	6.636e-110	364.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,3WFCF@539002|Bacillales incertae sedis	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD3_k127_2191531_0	316067.Geob_2616	2.299e-171	546.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,43TSR@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD3_k127_2191531_4	933262.AXAM01000033_gene1627	1.012e-101	341.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HFD3_k127_2191531_10	862965.PARA_13270	3.626e-07	54.0	2AWWG@1|root,31NU0@2|Bacteria,1NMXT@1224|Proteobacteria,1SIEV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2191531_6	330214.NIDE3962	1.504e-60	216.0	COG0705@1|root,COG0705@2|Bacteria,3J16E@40117|Nitrospirae	40117|Nitrospirae	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD3_k127_2191531_7	330214.NIDE2971	1.781e-24	109.0	COG3688@1|root,COG3688@2|Bacteria,3J0TU@40117|Nitrospirae	40117|Nitrospirae	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
HFD3_k127_2191531_2	1123371.ATXH01000022_gene959	2.207e-119	390.0	COG0436@1|root,COG0436@2|Bacteria,2GGY5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_220637_1	1144275.COCOR_00573	1.075e-145	475.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2YTUX@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD3_k127_220637_0	861299.J421_1872	2.305e-212	666.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HFD3_k127_2219057_2	195250.CM001776_gene555	1.008e-28	127.0	COG2251@1|root,COG2251@2|Bacteria,1G03D@1117|Cyanobacteria,1GYWA@1129|Synechococcus	1117|Cyanobacteria	S	nuclease (RecB family)	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas4,RNase_H_2
HFD3_k127_2219057_3	1160137.KB907307_gene87	2.687e-16	91.0	COG0715@1|root,COG0715@2|Bacteria,2HHNY@201174|Actinobacteria,4FZGF@85025|Nocardiaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2219057_0	479433.Caci_5825	3.087e-87	305.0	COG1032@1|root,COG1032@2|Bacteria,2GZU1@201174|Actinobacteria	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2219057_1	1356854.N007_14080	1.869e-35	139.0	COG0251@1|root,COG0251@2|Bacteria,1V7H7@1239|Firmicutes,4HJB0@91061|Bacilli	2|Bacteria	J	Endoribonuclease L-PSP	MA20_21375	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD3_k127_2226672_5	1028800.RG540_CH22730	1.951e-21	107.0	COG1840@1|root,COG1840@2|Bacteria,1PGNI@1224|Proteobacteria,2V7J9@28211|Alphaproteobacteria,4B9P8@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11
HFD3_k127_2226672_1	105425.BBPL01000045_gene3219	8.235e-88	308.0	COG1032@1|root,COG1032@2|Bacteria,2GZU1@201174|Actinobacteria,2NI0T@228398|Streptacidiphilus	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2226672_3	926550.CLDAP_28910	8.814e-38	149.0	COG4122@1|root,COG4122@2|Bacteria,2G97D@200795|Chloroflexi	200795|Chloroflexi	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
HFD3_k127_2226672_0	1120983.KB894571_gene2480	1.558e-89	314.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD3_k127_2226672_4	272134.KB731324_gene2628	2.137e-36	144.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	Z012_09115	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD3_k127_2280677_1	485913.Krac_12067	7.376e-21	98.0	COG5349@1|root,COG5349@2|Bacteria,2G7FQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HFD3_k127_2280677_0	243231.GSU2758	0.0	1790.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD3_k127_2280677_2	335543.Sfum_3248	1.126e-12	72.0	2EQZT@1|root,33IJD@2|Bacteria,1NKTX@1224|Proteobacteria,42XNG@68525|delta/epsilon subdivisions,2WTCK@28221|Deltaproteobacteria,2MQPM@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2333021_3	1131269.AQVV01000070_gene1533	1.444e-55	204.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HFD3_k127_2333021_6	335543.Sfum_1262	4.357e-08	63.0	COG1475@1|root,COG1475@2|Bacteria,1RISA@1224|Proteobacteria,42T1I@68525|delta/epsilon subdivisions,2WPDM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	ParB domain protein nuclease	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD3_k127_2333021_1	439235.Dalk_2812	9.008e-83	289.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria,2MHMR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_2333021_4	644966.Tmar_1759	2.84e-38	149.0	COG3427@1|root,COG3427@2|Bacteria,1VA2M@1239|Firmicutes,254US@186801|Clostridia	186801|Clostridia	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HFD3_k127_2333021_7	1226994.AMZB01000137_gene5520	1.435e-05	50.0	COG0810@1|root,COG0810@2|Bacteria,1PDQD@1224|Proteobacteria,1SWSN@1236|Gammaproteobacteria,1YETR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	TonB C terminal	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HFD3_k127_2333021_2	189753.AXAS01000041_gene2534	1.075e-72	257.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_2333021_0	196490.AUEZ01000023_gene7145	8.549e-122	403.0	COG0671@1|root,COG0671@2|Bacteria,1MWK1@1224|Proteobacteria,2U0HJ@28211|Alphaproteobacteria,3JWVD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HFD3_k127_2333021_8	1123054.KB907704_gene1199	3.999e-05	49.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
HFD3_k127_2333021_5	373903.Hore_00200	2.459e-25	112.0	2F7D8@1|root,33ZU9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2348946_2	223283.PSPTO_0155	7.926e-17	82.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1Z85E@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HFD3_k127_2348946_1	1211114.ALIP01000130_gene2193	3.885e-21	104.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1X5FX@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_2348946_0	1379698.RBG1_1C00001G1238	7.433e-50	199.0	COG5000@1|root,COG5000@2|Bacteria,2NQEP@2323|unclassified Bacteria	2|Bacteria	T	COGs COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1
HFD3_k127_2351725_3	1459636.NTE_00100	1.033e-51	188.0	COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HFD3_k127_2351725_5	1123508.JH636444_gene5253	1.323e-43	172.0	COG2423@1|root,COG2423@2|Bacteria,2IXT1@203682|Planctomycetes	203682|Planctomycetes	E	ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_2351725_4	99598.Cal7507_4477	5.692e-46	171.0	COG0625@1|root,COG0625@2|Bacteria,1G4XE@1117|Cyanobacteria,1HM97@1161|Nostocales	1117|Cyanobacteria	O	PFAM Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HFD3_k127_2351725_2	1125863.JAFN01000001_gene1630	2.77e-85	291.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,43AQ5@68525|delta/epsilon subdivisions,2X63Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_2351725_1	1499967.BAYZ01000076_gene838	2.337e-103	350.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_2351725_0	1499967.BAYZ01000028_gene1281	1.131e-143	472.0	COG0747@1|root,COG0747@2|Bacteria,2NR54@2323|unclassified Bacteria	2|Bacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_236509_4	1279017.AQYJ01000024_gene937	3.387e-40	156.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1S97V@1236|Gammaproteobacteria,468E0@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Flavin reductase like domain	-	-	-	ko:K09024	ko00240,ko01100,map00240,map01100	-	R09936	RC02732	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
HFD3_k127_236509_2	1519464.HY22_09445	2.356e-58	212.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD3_k127_236509_3	1121468.AUBR01000016_gene2342	3.456e-47	176.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,42G7Y@68295|Thermoanaerobacterales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD3_k127_236509_5	247490.KSU1_D0201	1.175e-39	153.0	COG0399@1|root,COG0399@2|Bacteria,2J1H7@203682|Planctomycetes	203682|Planctomycetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD3_k127_236509_1	671143.DAMO_1294	4.933e-63	222.0	COG0468@1|root,COG0468@2|Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553,ko:K14160	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD3_k127_236509_0	671143.DAMO_1293	7.694e-149	488.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346,ko:K14161	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
HFD3_k127_236509_6	266835.14027370	3.356e-17	92.0	COG1028@1|root,COG1028@2|Bacteria,1RBAD@1224|Proteobacteria,2U5CK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase Sdr	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_236509_7	671143.DAMO_1295	2.753e-10	61.0	COG4422@1|root,COG4422@2|Bacteria	2|Bacteria	F	Protein of unknown function (DUF5131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
HFD3_k127_2365106_7	1206744.BAGL01000124_gene6549	1.388e-87	317.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_2365106_5	395493.BegalDRAFT_0516	9.684e-123	402.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_2365106_2	1034943.BN1094_03603	1.33e-157	508.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1JCTF@118969|Legionellales	118969|Legionellales	C	Citrate synthase, C-terminal domain	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
HFD3_k127_2365106_0	1131730.BAVI_08331	2.789e-224	703.0	COG2079@1|root,COG2079@2|Bacteria,1TRR8@1239|Firmicutes,4HAUS@91061|Bacilli,1ZCS6@1386|Bacillus	91061|Bacilli	S	2-methylcitrate dehydratase	prpD	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0047547,GO:0071704	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HFD3_k127_2365106_8	882083.SacmaDRAFT_0642	1.856e-86	294.0	COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria,4E0PY@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.32	ko:K20454	ko00760,ko01120,map00760,map01120	-	R01355	RC00286,RC01810	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HFD3_k127_2365106_1	1123371.ATXH01000002_gene346	2.045e-212	695.0	COG0308@1|root,COG0793@1|root,COG3016@1|root,COG0308@2|Bacteria,COG0793@2|Bacteria,COG3016@2|Bacteria,2GH6S@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2,Peptidase_M1
HFD3_k127_2365106_13	436229.JOEH01000011_gene5515	0.0002392	48.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,2NG79@228398|Streptacidiphilus	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_2365106_9	1231190.NA8A_02305	1.046e-76	274.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,43RMY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Mmge prpd family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_2365106_12	935840.JAEQ01000004_gene646	8.775e-17	92.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2365106_4	479434.Sthe_1452	2.811e-137	457.0	COG1053@1|root,COG1053@2|Bacteria,2GA4Y@200795|Chloroflexi,27Z93@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD binding domain	-	-	1.3.99.4	ko:K05898,ko:K13796	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09884	RC00991	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
HFD3_k127_2365106_10	1231391.AMZF01000094_gene98	8.928e-54	203.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_2365106_6	1042377.AFPJ01000008_gene1982	2.747e-113	377.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,465ME@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_2365106_3	1547437.LL06_25225	5.311e-152	492.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TT8I@28211|Alphaproteobacteria,43JYS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aconitase family (aconitate hydratase)	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD3_k127_2365106_11	309801.trd_1692	1.614e-40	155.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi,27Y7V@189775|Thermomicrobia	189775|Thermomicrobia	E	Belongs to the LeuD family	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD3_k127_2371303_2	1123371.ATXH01000001_gene1275	3.933e-44	164.0	COG0330@1|root,COG0330@2|Bacteria,2GHBQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD3_k127_2371303_0	472759.Nhal_1884	1.831e-223	701.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WZYK@135613|Chromatiales	135613|Chromatiales	H	Belongs to the RtcB family	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD3_k127_2371303_1	292415.Tbd_2360	3.833e-51	185.0	COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
HFD3_k127_2383212_10	756883.Halar_1090	1.669e-06	53.0	COG2314@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM2,zf-ribbon_3,zinc_ribbon_2
HFD3_k127_2383212_1	1173026.Glo7428_0087	4.668e-130	424.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_2383212_0	748247.AZKH_1022	1.502e-174	552.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales	206389|Rhodocyclales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HFD3_k127_2383212_9	640081.Dsui_2122	1.23e-08	66.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2WEG1@28216|Betaproteobacteria,2KVYA@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_2383212_8	645991.Sgly_0970	5.748e-13	80.0	COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,24D4Q@186801|Clostridia,262FA@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM ABC transporter, substrate-binding protein, aliphatic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,OmpA
HFD3_k127_2383212_3	77635.BISU_1704	9.644e-55	211.0	COG1878@1|root,COG1878@2|Bacteria,2ICNS@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	ko:K14250	ko00253,ko01057,ko01130,map00253,map01057,map01130	M00778	R09188,R09325,R09326,R09350	RC02459,RC02512,RC02517	ko00000,ko00001,ko00002	-	-	-	Cyclase
HFD3_k127_2383212_5	1118054.CAGW01000010_gene3953	1.668e-47	189.0	COG1878@1|root,COG1878@2|Bacteria,1USBQ@1239|Firmicutes,4HGJW@91061|Bacilli,26SAY@186822|Paenibacillaceae	91061|Bacilli	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD3_k127_2383212_2	378806.STAUR_3903	1.74e-89	316.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6,2.3.3.15	ko:K01652,ko:K03852	ko00290,ko00430,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_2383212_7	479435.Kfla_6159	6.005e-24	115.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,4DN0M@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_2383212_4	378806.STAUR_6060	1.884e-48	184.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WPYW@28221|Deltaproteobacteria,2Z30A@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD3_k127_2387618_7	1509405.GV67_12630	2.305e-17	91.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2387618_8	1121127.JAFA01000004_gene1333	1.616e-16	86.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA,TctB
HFD3_k127_2387618_1	443152.MDG893_15285	1.168e-117	396.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_2387618_5	1144310.PMI07_005585	1.566e-26	122.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2387618_4	1144310.PMI07_005585	1.177e-32	140.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2387618_0	76114.p2A120	3.259e-137	455.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_2387618_3	1382304.JNIL01000001_gene3039	7.007e-40	160.0	COG0329@1|root,COG0329@2|Bacteria,1TPVS@1239|Firmicutes,4HATJ@91061|Bacilli	91061|Bacilli	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_2387618_2	857571.EA1_03250	4.615e-65	231.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,3NKAW@468|Moraxellaceae	1236|Gammaproteobacteria	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HFD3_k127_2387618_6	1356854.N007_12890	8.479e-19	89.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HD58@91061|Bacilli	91061|Bacilli	E	Ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_2390260_2	765913.ThidrDRAFT_0469	3.205e-06	51.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD3_k127_2390260_0	1396418.BATQ01000120_gene3078	4.777e-122	428.0	COG4191@1|root,COG4191@2|Bacteria,46ZJR@74201|Verrucomicrobia,2IV4D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HFD3_k127_2390260_1	1218084.BBJK01000057_gene4401	1.459e-67	240.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2VQH8@28216|Betaproteobacteria,1JZZ5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD3_k127_2390355_12	1266925.JHVX01000013_gene1657	8.248e-17	94.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HFD3_k127_2390355_5	1121448.DGI_1413	1.248e-82	294.0	29D6U@1|root,3004T@2|Bacteria,1R9I1@1224|Proteobacteria,42T9I@68525|delta/epsilon subdivisions,2WPXB@28221|Deltaproteobacteria,2MADE@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2390355_9	391038.Bphy_0646	3.135e-38	148.0	COG4566@1|root,COG4566@2|Bacteria,1MZ8E@1224|Proteobacteria,2VYAI@28216|Betaproteobacteria,1K8D8@119060|Burkholderiaceae	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_2390355_10	1266925.JHVX01000013_gene1657	1.335e-26	116.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HFD3_k127_2390355_6	1502851.FG93_04653	7.315e-81	283.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,3JXB7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD3_k127_2390355_7	1037409.BJ6T_21760	8.368e-70	244.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HFD3_k127_2390355_11	243233.MCA2763	9.006e-19	88.0	2CN1D@1|root,32SG1@2|Bacteria,1N9DS@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
HFD3_k127_2390355_13	1336243.JAEA01000005_gene1347	0.0002075	48.0	COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2UBT7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HFD3_k127_2390355_1	211165.AJLN01000079_gene367	0.0	1202.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,1JJZ1@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD3_k127_2390355_0	395961.Cyan7425_2475	0.0	1211.0	COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,3KFUI@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HFD3_k127_2390355_3	690850.Desaf_2574	1.581e-191	607.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2M7WH@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
HFD3_k127_2390355_8	717785.HYPMC_3624	1.646e-54	195.0	COG2149@1|root,COG2149@2|Bacteria,1RKB3@1224|Proteobacteria,2UEIP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HFD3_k127_2390355_2	1173024.KI912152_gene364	1.39e-292	902.0	COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria,1JJCF@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HFD3_k127_2390355_4	522306.CAP2UW1_0198	1.26e-83	278.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD3_k127_2401382_15	1123242.JH636434_gene4881	0.0004438	47.0	2EKWU@1|root,33EKC@2|Bacteria,2J1EP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2401382_7	1192034.CAP_8932	2.415e-21	96.0	COG3861@1|root,COG3861@2|Bacteria,1QE0P@1224|Proteobacteria,42TDZ@68525|delta/epsilon subdivisions,2WPW5@28221|Deltaproteobacteria,2Z2TG@29|Myxococcales	28221|Deltaproteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2401382_12	1184267.A11Q_363	1.72e-09	60.0	2EMKC@1|root,33F8T@2|Bacteria,1NP5C@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2401382_6	1463895.JODA01000023_gene4126	1.448e-25	111.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD3_k127_2401382_4	272134.KB731324_gene4403	3.512e-83	287.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD3_k127_2401382_11	234267.Acid_2877	5.601e-14	79.0	COG0628@1|root,COG0628@2|Bacteria,3Y6C3@57723|Acidobacteria	2|Bacteria	T	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport,GAF,GAF_2
HFD3_k127_2401382_3	1210884.HG799464_gene11081	1.908e-97	336.0	COG0628@1|root,COG0628@2|Bacteria,2IXF5@203682|Planctomycetes	203682|Planctomycetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD3_k127_2401382_9	635013.TherJR_2008	1.864e-17	87.0	2ERYM@1|root,33JHS@2|Bacteria,1VMJJ@1239|Firmicutes,2530R@186801|Clostridia	186801|Clostridia	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
HFD3_k127_2401382_0	671143.DAMO_0975	1.017e-247	783.0	COG0465@1|root,COG0465@2|Bacteria,2NP22@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD3_k127_2401382_14	861299.J421_3379	7.769e-08	58.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
HFD3_k127_2401382_2	56780.SYN_02631	6.657e-141	463.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,42XYJ@68525|delta/epsilon subdivisions,2WSKT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HFD3_k127_2401382_5	237368.SCABRO_02165	5.772e-37	151.0	COG0589@1|root,COG0589@2|Bacteria,2J12B@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related	-	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
HFD3_k127_2401382_13	909613.UO65_0943	5.049e-08	61.0	COG0664@1|root,COG0664@2|Bacteria,2INMI@201174|Actinobacteria,4EBXN@85010|Pseudonocardiales	201174|Actinobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_2401382_8	635013.TherJR_2008	5.984e-20	95.0	2ERYM@1|root,33JHS@2|Bacteria,1VMJJ@1239|Firmicutes,2530R@186801|Clostridia	186801|Clostridia	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
HFD3_k127_2401382_1	1131814.JAFO01000001_gene3315	2.441e-169	549.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3EYBF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HFD3_k127_2407700_3	395963.Bind_0227	1.907e-06	53.0	COG3577@1|root,COG5010@1|root,COG3577@2|Bacteria,COG5010@2|Bacteria,1R8QA@1224|Proteobacteria,2U3CI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_16,gag-asp_proteas
HFD3_k127_2407700_1	1297742.A176_02040	1.223e-10	71.0	COG0745@1|root,COG0745@2|Bacteria,1NQ8U@1224|Proteobacteria,42QWX@68525|delta/epsilon subdivisions,2WN80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
HFD3_k127_2407700_2	926554.KI912660_gene2430	1.022e-09	68.0	COG2770@1|root,COG2770@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
HFD3_k127_2407700_0	1173263.Syn7502_03004	4.322e-63	231.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2441288_4	1500897.JQNA01000002_gene4353	9.084e-11	73.0	COG0715@1|root,COG0715@2|Bacteria,1R3SJ@1224|Proteobacteria,2VMUC@28216|Betaproteobacteria,1K1MD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Nitrate ABC transporter substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2441288_1	443152.MDG893_15040	9.792e-94	321.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria	1224|Proteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_2441288_3	1231391.AMZF01000020_gene1928	1.061e-40	165.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_2441288_0	1144310.PMI07_004503	9.543e-199	634.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,4B8UI@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase, alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_2441288_2	1265313.HRUBRA_01048	4.22e-62	225.0	COG2267@1|root,COG2267@2|Bacteria,1R79U@1224|Proteobacteria,1S3DE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	phaG	-	-	ko:K18100	ko02024,ko02025,map02024,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT1	-	Abhydrolase_1,Hydrolase_4
HFD3_k127_2453053_0	1384484.AEQU_1275	4.359e-141	477.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CWZW@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_2453053_2	1210908.HSB1_30160	0.0009685	48.0	COG1977@1|root,arCOG00536@2157|Archaea,2XYN8@28890|Euryarchaeota,23WSK@183963|Halobacteria	183963|Halobacteria	H	COG1977 Molybdopterin converting factor, small subunit	samp1	GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD3_k127_2453053_1	481805.EcolC_3954	0.0001228	47.0	COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,1RQ22@1236|Gammaproteobacteria,3XNMB@561|Escherichia	1236|Gammaproteobacteria	P	Polysulphide reductase, NrfD	nrfD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K04015	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_2382,iE2348C_1286.E2348C_4396,iECABU_c1320.ECABU_c46180,iECOK1_1307.ECOK1_4578,iECP_1309.ECP_4306,iECS88_1305.ECS88_4566,iLF82_1304.LF82_1523,iNRG857_1313.NRG857_20400,iUMN146_1321.UM146_20560,iUTI89_1310.UTI89_C4663,ic_1306.c5069	NrfD
HFD3_k127_2473151_16	1173021.ALWA01000021_gene714	8.071e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,1G07G@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
HFD3_k127_2473151_11	595494.Tola_1246	6.551e-87	292.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1S4GN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_2473151_4	398767.Glov_1801	8.77e-149	483.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42PIT@68525|delta/epsilon subdivisions,2WKT1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG4591 ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_2473151_9	177437.HRM2_39210	1.147e-95	321.0	COG2834@1|root,COG2834@2|Bacteria,1R5CY@1224|Proteobacteria,42PWK@68525|delta/epsilon subdivisions,2WKW1@28221|Deltaproteobacteria,2MI9E@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
HFD3_k127_2473151_8	398767.Glov_1799	6.081e-103	353.0	28IZT@1|root,2Z8X3@2|Bacteria,1R4RF@1224|Proteobacteria,42QV2@68525|delta/epsilon subdivisions,2WMYU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2473151_7	795359.TOPB45_1234	2.599e-106	357.0	COG2059@1|root,COG2059@2|Bacteria,2GHF7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_2473151_0	330214.NIDE3866	0.0	1017.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,3J0ZI@40117|Nitrospirae	40117|Nitrospirae	C	ATP-grasp domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD3_k127_2473151_15	272943.RSP_3168	1.596e-09	70.0	COG0715@1|root,COG0715@2|Bacteria,1R60E@1224|Proteobacteria,2U09M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter (Periplasmic binding protein)	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2473151_13	76114.ebA5631	9.622e-50	189.0	COG3301@1|root,COG3301@2|Bacteria,1N6TR@1224|Proteobacteria	1224|Proteobacteria	P	DMSO reductase anchor subunit (DmsC)	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD3_k127_2473151_10	76114.ebA5630	2.961e-89	299.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,2KUFD@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HFD3_k127_2473151_2	76114.ebA5622	1.776e-253	808.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_2473151_5	1348657.M622_05005	1.541e-135	439.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KVJ5@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S dicluster domain	-	-	-	ko:K17048,ko:K17051	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko02000	5.A.3.8,5.A.3.9	-	-	Fer4_11
HFD3_k127_2473151_14	1348657.M622_05065	6.633e-18	92.0	COG3381@1|root,COG3381@2|Bacteria,1RAXF@1224|Proteobacteria,2VY6I@28216|Betaproteobacteria,2KXH2@206389|Rhodocyclales	206389|Rhodocyclales	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HFD3_k127_2473151_1	1348657.M622_05010	1.356e-268	855.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2473151_6	58344.JOEL01000022_gene962	6.024e-132	436.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_2473151_3	1348657.M622_05010	6.001e-236	759.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2473151_12	189426.PODO_11600	2.113e-61	227.0	COG0826@1|root,COG0826@2|Bacteria,1UYPK@1239|Firmicutes,4HW2A@91061|Bacilli,26WVP@186822|Paenibacillaceae	91061|Bacilli	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
HFD3_k127_2477282_2	1121405.dsmv_2768	5.942e-31	130.0	COG1807@1|root,COG1807@2|Bacteria,1MY0U@1224|Proteobacteria,42QGD@68525|delta/epsilon subdivisions,2WM6Q@28221|Deltaproteobacteria,2MJRD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_2477282_4	278963.ATWD01000001_gene3203	1.378e-12	73.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria,2JHPY@204432|Acidobacteriia	204432|Acidobacteriia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD3_k127_2477282_3	1385935.N836_10780	2.179e-13	78.0	COG0625@1|root,COG0625@2|Bacteria,1G1DY@1117|Cyanobacteria,1H9SY@1150|Oscillatoriales	1117|Cyanobacteria	O	Glutathione S-transferase	gst1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD3_k127_2477282_1	330214.NIDE2788	5.326e-38	150.0	2EBKA@1|root,335KQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2477282_5	1312954.KI914891_gene2111	4.992e-08	58.0	COG3339@1|root,COG3339@2|Bacteria,2IMW8@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HFD3_k127_2477282_0	671143.DAMO_2569	7.264e-148	479.0	COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria	2|Bacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HFD3_k127_2499293_1	298654.FraEuI1c_2811	9.442e-09	61.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_2499293_0	1502851.FG93_00182	1.491e-47	192.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
HFD3_k127_250606_2	1041138.KB890221_gene1233	5.787e-24	106.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,4BBTT@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_250606_1	305700.B447_18924	1.308e-58	213.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VKJC@28216|Betaproteobacteria,2KXYU@206389|Rhodocyclales	206389|Rhodocyclales	U	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_250606_0	1123501.KB902290_gene1558	1.506e-122	399.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA	-	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_250606_3	189753.AXAS01000040_gene2109	1.057e-23	113.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,2TRS0@28211|Alphaproteobacteria,3JTSE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2508565_3	335543.Sfum_3075	1.253e-25	116.0	COG0746@1|root,COG0746@2|Bacteria,1PJ8A@1224|Proteobacteria,43A1A@68525|delta/epsilon subdivisions,2X2C8@28221|Deltaproteobacteria,2MQMN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD3_k127_2508565_0	479434.Sthe_3386	1.297e-195	627.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,27XT3@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HFD3_k127_2508565_2	667632.KB890165_gene2521	5.942e-38	155.0	COG2358@1|root,COG2358@2|Bacteria	2|Bacteria	G	TRAP transporter, solute receptor (TAXI family	-	-	3.2.1.52	ko:K01207,ko:K07080	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2491,NMT1_3,Pkinase,TIR_2,TPR_10
HFD3_k127_2508565_4	237368.SCABRO_02862	0.0001298	49.0	2EQ22@1|root,33HNG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2508565_1	243231.GSU0037	1.27e-93	309.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,43SZ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
HFD3_k127_250930_4	880072.Desac_2180	4.048e-12	67.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD3_k127_250930_6	529818.AMSG_10860T0	3.526e-07	53.0	COG1249@1|root,KOG0405@2759|Eukaryota	2759|Eukaryota	C	glutathione-disulfide reductase activity	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD3_k127_250930_1	1122128.AUEE01000016_gene2072	1.491e-70	253.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HBZF@91061|Bacilli,4GY72@90964|Staphylococcaceae	91061|Bacilli	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD3_k127_250930_2	1547437.LL06_19570	9.818e-31	131.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2V8CK@28211|Alphaproteobacteria,43QNT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1989
HFD3_k127_250930_0	335543.Sfum_2336	5.011e-293	906.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HFD3_k127_250930_5	292459.STH3219	1.896e-07	59.0	COG1840@1|root,COG1840@2|Bacteria,1UYVQ@1239|Firmicutes,25C4Y@186801|Clostridia	186801|Clostridia	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_2522362_15	1395571.TMS3_0107680	9.833e-15	81.0	COG0697@1|root,COG0697@2|Bacteria,1R6SK@1224|Proteobacteria	1224|Proteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_2522362_8	1231391.AMZF01000040_gene499	3.27e-85	291.0	COG0410@1|root,COG0410@2|Bacteria,1MUFR@1224|Proteobacteria,2VM45@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HFD3_k127_2522362_6	1472716.KBK24_0119835	3.419e-91	312.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKMU@28216|Betaproteobacteria,1K2J3@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HFD3_k127_2522362_5	1231391.AMZF01000040_gene501	1.28e-112	378.0	COG4177@1|root,COG4177@2|Bacteria,1MYF5@1224|Proteobacteria,2VKGD@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD3_k127_2522362_4	1380394.JADL01000001_gene3040	4.667e-118	386.0	COG0559@1|root,COG0559@2|Bacteria,1NQYP@1224|Proteobacteria,2TSH6@28211|Alphaproteobacteria,2JRU1@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD3_k127_2522362_2	1380394.JADL01000001_gene3041	9.544e-153	494.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2TU2B@28211|Alphaproteobacteria,2JQHQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD3_k127_2522362_0	1244869.H261_05239	3.822e-283	886.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VF1V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1
HFD3_k127_2522362_7	933262.AXAM01000036_gene2178	3.428e-87	305.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,43B26@68525|delta/epsilon subdivisions,2X6G6@28221|Deltaproteobacteria,2MKC2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_2522362_3	449447.MAE_35850	9.164e-152	518.0	COG0664@1|root,COG2274@1|root,COG0664@2|Bacteria,COG2274@2|Bacteria,1FZZ2@1117|Cyanobacteria	1117|Cyanobacteria	V	Type I secretion system ABC transporter, HlyB family	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding
HFD3_k127_2522362_10	1121396.KB892935_gene3861	3.854e-51	198.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_2522362_14	1504672.669784804	2.774e-17	87.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,4ABX0@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD3_k127_2522362_11	1267535.KB906767_gene635	4.174e-38	154.0	COG2968@1|root,COG2968@2|Bacteria,3Y844@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HFD3_k127_2522362_9	1395587.P364_0120485	1.432e-57	207.0	COG0454@1|root,COG0456@2|Bacteria,1VW2R@1239|Firmicutes,4I7IK@91061|Bacilli,26WWV@186822|Paenibacillaceae	91061|Bacilli	K	GNAT family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HFD3_k127_2522362_1	317619.ANKN01000196_gene13	3.861e-159	524.0	COG1020@1|root,COG1020@2|Bacteria,1G3NP@1117|Cyanobacteria	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_2522362_13	1134413.ANNK01000127_gene2529	7.696e-25	106.0	COG0726@1|root,COG0726@2|Bacteria,1VA2Q@1239|Firmicutes,4HEX3@91061|Bacilli,1ZK98@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_2526070_2	1380394.JADL01000002_gene1437	1.789e-63	222.0	2C02K@1|root,32R69@2|Bacteria,1RK2Q@1224|Proteobacteria,2U9PI@28211|Alphaproteobacteria,2JT3N@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2526070_1	443152.MDG893_15307	1.004e-64	235.0	2C1EV@1|root,33RW1@2|Bacteria,1R3AA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2526070_3	604331.AUHY01000001_gene1265	5.509e-52	192.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_2526070_0	311403.Arad_7168	2.451e-104	348.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4B7Q4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD3_k127_2528033_1	247639.MGP2080_11223	2.009e-94	321.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1J4MX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD3_k127_2528033_2	251229.Chro_1416	1.126e-81	277.0	COG3340@1|root,COG3340@2|Bacteria,1G6TI@1117|Cyanobacteria,3VMJQ@52604|Pleurocapsales	1117|Cyanobacteria	E	Peptidase family S51	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S51
HFD3_k127_2528033_0	1007105.PT7_0956	1.141e-131	430.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2W0AM@28216|Betaproteobacteria,3T617@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_2528033_3	395964.KE386496_gene3114	2.829e-50	185.0	COG0500@1|root,COG2226@2|Bacteria,1RKPU@1224|Proteobacteria,2UDN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD3_k127_2547777_3	1237149.C900_02976	4.143e-10	63.0	COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4P1A1@976|Bacteroidetes	976|Bacteroidetes	E	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2547777_2	1144310.PMI07_005447	9.057e-50	190.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2547777_0	797299.HALLA_02515	2.776e-77	273.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAS@28890|Euryarchaeota,23SVB@183963|Halobacteria	183963|Halobacteria	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD3_k127_2547777_1	1121396.KB892935_gene3861	5.485e-61	228.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_2568165_6	706587.Desti_4721	1.889e-16	81.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2568165_7	706587.Desti_4721	5.22e-15	78.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2568165_1	706587.Desti_4722	2.385e-133	445.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HFD3_k127_2568165_4	1170562.Cal6303_1723	1.205e-54	198.0	COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1HMWG@1161|Nostocales	1117|Cyanobacteria	J	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_2568165_8	316067.Geob_3656	2.072e-13	74.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
HFD3_k127_2568165_5	1382356.JQMP01000003_gene2027	9.93e-32	134.0	COG0412@1|root,COG0412@2|Bacteria,2G9WC@200795|Chloroflexi,27Z94@189775|Thermomicrobia	189775|Thermomicrobia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_2568165_2	1480694.DC28_07950	5.418e-71	247.0	COG0066@1|root,COG0066@2|Bacteria,2JACS@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HFD3_k127_2568165_0	321332.CYB_0327	2.615e-212	667.0	COG0065@1|root,COG0065@2|Bacteria,1G1J0@1117|Cyanobacteria,1GZ9E@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD3_k127_2591783_5	742765.HMPREF9457_00743	2.139e-10	70.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,27V2W@189330|Dorea	186801|Clostridia	P	COG COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2591783_1	309801.trd_A0621	1.724e-109	370.0	COG0477@1|root,COG2814@2|Bacteria,2G8FT@200795|Chloroflexi,27Z09@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Sugar (and other) transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	Sugar_tr
HFD3_k127_2591783_4	1157490.EL26_06930	2.193e-58	206.0	COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,4HHKH@91061|Bacilli,27A3N@186823|Alicyclobacillaceae	91061|Bacilli	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HFD3_k127_2591783_0	138119.DSY4783	4.63e-148	498.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2591783_3	138119.DSY4782	1.325e-79	273.0	COG0437@1|root,COG0437@2|Bacteria,1V4KV@1239|Firmicutes,24HGE@186801|Clostridia	2|Bacteria	C	DMSO reductase, iron-sulfur subunit	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4
HFD3_k127_2591783_6	666510.ASAC_0577	1.058e-07	56.0	COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HFD3_k127_2591783_2	266779.Meso_2926	9.314e-108	358.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_2618540_6	1120949.KB903295_gene2308	2.938e-39	169.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,2H0S2@201174|Actinobacteria	2|Bacteria	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE,SIR2_2
HFD3_k127_2618540_12	489825.LYNGBM3L_51240	0.0001597	52.0	COG2242@1|root,COG2242@2|Bacteria,1G48K@1117|Cyanobacteria,1H9X5@1150|Oscillatoriales	1117|Cyanobacteria	H	TIGRFAM methyltransferase FkbM family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD3_k127_2618540_2	253839.SSNG_00450	2.777e-96	326.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria	201174|Actinobacteria	M	epimerase dehydratase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD3_k127_2618540_8	420324.KI912082_gene6896	9.929e-18	92.0	COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,2TUNY@28211|Alphaproteobacteria,1JZ9D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HFD3_k127_2618540_3	1238182.C882_2282	6.434e-83	279.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2JPZG@204441|Rhodospirillales	28211|Alphaproteobacteria	L	Transposase mutator type	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
HFD3_k127_2618540_9	452637.Oter_3749	9.491e-09	58.0	COG3267@1|root,COG3267@2|Bacteria,46SXM@74201|Verrucomicrobia,3K91Q@414999|Opitutae	414999|Opitutae	U	Pfam:Arch_ATPase	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
HFD3_k127_2618540_4	85643.Tmz1t_0174	2.717e-75	262.0	COG1674@1|root,COG1674@2|Bacteria,1RCMG@1224|Proteobacteria	1224|Proteobacteria	D	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2618540_7	313624.NSP_32490	3.318e-39	151.0	COG3675@1|root,COG5373@1|root,COG3675@2|Bacteria,COG5373@2|Bacteria,1GFF5@1117|Cyanobacteria,1HT8J@1161|Nostocales	2|Bacteria	I	Lamin Tail Domain	-	-	2.4.1.21	ko:K00703,ko:K01990,ko:K02519,ko:K11904	ko00500,ko01100,ko01110,ko02026,ko03070,map00500,map01100,map01110,map02026,map03070	M00254,M00334,M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02044,ko03012,ko03029	3.A.1,3.A.23.1	GT5	-	FecR,LRR_5,Lipase_3
HFD3_k127_2618540_11	1114964.L485_14765	2.747e-07	55.0	COG3267@1|root,COG3267@2|Bacteria,1N4AU@1224|Proteobacteria,2VCN0@28211|Alphaproteobacteria,2K2SN@204457|Sphingomonadales	204457|Sphingomonadales	U	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HFD3_k127_2618540_10	215803.DB30_6605	4.243e-08	62.0	COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria	1224|Proteobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HFD3_k127_2618540_5	574375.BAGA_09620	5.06e-73	250.0	COG1961@1|root,COG1961@2|Bacteria,1UZT3@1239|Firmicutes,4HCR8@91061|Bacilli,1ZQD4@1386|Bacillus	91061|Bacilli	L	Resolvase, N terminal domain	binR	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HFD3_k127_2618540_0	1079460.ATTQ01000029_gene4706	6.356e-202	637.0	COG0784@1|root,COG3920@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c,HWE_HK,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
HFD3_k127_2618540_1	366602.Caul_0471	1.486e-128	422.0	COG3920@1|root,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U4H4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_9
HFD3_k127_2646080_2	243231.GSU0942	2.385e-48	179.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,43SF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD3_k127_2646080_1	443143.GM18_2654	8.473e-63	226.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2WNJR@28221|Deltaproteobacteria,43TCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD3_k127_2646080_5	644282.Deba_0726	4.412e-35	138.0	COG2088@1|root,COG2088@2|Bacteria,1N14Y@1224|Proteobacteria,42TGF@68525|delta/epsilon subdivisions,2WQYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
HFD3_k127_2646080_0	1123371.ATXH01000007_gene554	5.462e-132	430.0	COG0462@1|root,COG0462@2|Bacteria,2GGWM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD3_k127_2646080_4	1379281.AVAG01000010_gene1305	3.328e-37	148.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2WQIY@28221|Deltaproteobacteria,2M9S4@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD3_k127_2646080_3	648996.Theam_0298	2.51e-45	168.0	COG0193@1|root,COG0193@2|Bacteria,2G42F@200783|Aquificae	200783|Aquificae	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD3_k127_2659325_3	1131814.JAFO01000001_gene4403	1.591e-45	177.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD3_k127_2659325_6	1144310.PMI07_005439	5.585e-36	148.0	COG0600@1|root,COG0600@2|Bacteria,1PF1W@1224|Proteobacteria,2UQ2K@28211|Alphaproteobacteria,4BJDU@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_2659325_8	311403.Arad_7223	9.257e-30	129.0	COG0600@1|root,COG0600@2|Bacteria,1Q2EA@1224|Proteobacteria,2UQF8@28211|Alphaproteobacteria,4BJE7@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_2659325_5	1380394.JADL01000001_gene3070	2.087e-42	168.0	COG0715@1|root,COG0715@2|Bacteria,1NAXC@1224|Proteobacteria,2U2C2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2659325_2	1437824.BN940_06921	1.252e-93	314.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,3T3UP@506|Alcaligenaceae	28216|Betaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_2659325_1	1123278.KB893417_gene1249	8.548e-105	358.0	COG0154@1|root,COG0154@2|Bacteria,4P0YK@976|Bacteroidetes,47XG7@768503|Cytophagia	976|Bacteroidetes	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD3_k127_2659325_11	1121929.KB898671_gene4138	1.522e-12	79.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli	91061|Bacilli	IQ	Activates fatty acids by binding to coenzyme A	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_2659325_9	1125863.JAFN01000001_gene1221	2.532e-27	128.0	COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HFD3_k127_2659325_13	1266908.AQPB01000054_gene1721	8.862e-06	57.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1T175@1236|Gammaproteobacteria,1X24J@135613|Chromatiales	135613|Chromatiales	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HFD3_k127_2659325_7	234267.Acid_3504	1.328e-31	130.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	petA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HFD3_k127_2659325_0	234267.Acid_3505	1.951e-127	420.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD3_k127_2659325_4	671143.DAMO_0769	1.336e-42	170.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	pcmF	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_2659325_12	1121121.KB894293_gene1272	6.951e-09	67.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1TRC3@1239|Firmicutes,4HADQ@91061|Bacilli,26R5S@186822|Paenibacillaceae	91061|Bacilli	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD3_k127_2659325_10	1121456.ATVA01000015_gene2497	4.041e-16	87.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2X2AA@28221|Deltaproteobacteria,2MF3K@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,FixO
HFD3_k127_2668746_6	671143.DAMO_0095	3.275e-63	231.0	COG1282@1|root,COG1282@2|Bacteria,2NQMF@2323|unclassified Bacteria	2|Bacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HFD3_k127_2668746_9	671143.DAMO_0094	1.018e-29	132.0	COG3288@1|root,COG3288@2|Bacteria,2NRJW@2323|unclassified Bacteria	2|Bacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HFD3_k127_2668746_2	502025.Hoch_1910	6.885e-122	402.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2YUHD@29|Myxococcales	28221|Deltaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HFD3_k127_2668746_3	330214.NIDE3865	1.965e-109	365.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HFD3_k127_2668746_0	1210884.HG799465_gene12283	0.0	1166.0	COG0542@1|root,COG0542@2|Bacteria,2IWYZ@203682|Planctomycetes	203682|Planctomycetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD3_k127_2668746_12	338963.Pcar_1063	9.179e-08	63.0	COG1734@1|root,COG1734@2|Bacteria,1Q48Z@1224|Proteobacteria,43E2S@68525|delta/epsilon subdivisions,2WWWM@28221|Deltaproteobacteria,43VKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD3_k127_2668746_4	1297742.A176_05554	7.53e-80	280.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,439QP@68525|delta/epsilon subdivisions,2X537@28221|Deltaproteobacteria,2Z01T@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix domain	dpbF	-	-	-	-	-	-	-	-	-	-	-	HHH_5,HHH_8
HFD3_k127_2668746_8	338963.Pcar_0274	5.361e-44	167.0	COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,43UM1@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD3_k127_2668746_5	1123368.AUIS01000038_gene38	5.119e-77	263.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,1S3SH@1236|Gammaproteobacteria,2NCU9@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HFD3_k127_2668746_10	1123389.ATXJ01000004_gene1243	1.091e-21	102.0	COG0517@1|root,COG0517@2|Bacteria,1WI6I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HFD3_k127_2668746_11	671143.DAMO_2263	1.952e-12	71.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HFD3_k127_2668746_1	880073.Calab_3404	3.026e-136	447.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667,ko:K07714	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_2668746_7	1304874.JAFY01000002_gene36	2.26e-61	238.0	COG3452@1|root,COG5002@1|root,COG3452@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	phoR_2	-	2.7.13.3	ko:K02484,ko:K11206,ko:K11383	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE,CHASE2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HFD3_k127_2673726_1	338969.Rfer_0691	2.3e-89	313.0	COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2WEWR@28216|Betaproteobacteria,4AJNX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
HFD3_k127_2673726_0	46234.ANA_C11802	1.321e-235	756.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HRM7@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
HFD3_k127_2680881_3	1173022.Cri9333_4380	5.48e-39	152.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD3_k127_2680881_4	1123392.AQWL01000006_gene609	2.396e-08	65.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KSUM@119069|Hydrogenophilales	119069|Hydrogenophilales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD3_k127_2680881_1	228410.NE1238	5.477e-45	168.0	COG2373@1|root,COG2373@2|Bacteria,1Q2SN@1224|Proteobacteria	1224|Proteobacteria	I	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HFD3_k127_2680881_2	518766.Rmar_0504	1.306e-39	149.0	COG1372@1|root,COG1690@1|root,COG1372@2|Bacteria,COG1690@2|Bacteria,4PJG7@976|Bacteroidetes,1FIJQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD3_k127_2680881_0	880073.Calab_3125	1.316e-141	458.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HFD3_k127_2680881_5	591157.SSLG_05761	0.0001622	48.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2684126_0	1123279.ATUS01000001_gene1336	4.953e-130	432.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J7U9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_2684126_1	1123368.AUIS01000011_gene1180	1.294e-32	136.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD3_k127_2687941_2	1499967.BAYZ01000061_gene5954	2.259e-58	207.0	COG1533@1|root,COG1533@2|Bacteria,2NPZ9@2323|unclassified Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HFD3_k127_2687941_1	243231.GSU2923	6.396e-92	309.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,43TAQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HFD3_k127_2687941_0	330214.NIDE0623	1.31e-301	964.0	COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD3_k127_2687941_3	1242864.D187_003792	1.723e-50	192.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,42X9G@68525|delta/epsilon subdivisions,2WSQS@28221|Deltaproteobacteria,2YV88@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HFD3_k127_2694091_3	743720.Psefu_1298	1.698e-16	91.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,1SF34@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,TAT_signal
HFD3_k127_2694091_5	909663.KI867150_gene668	0.0003354	48.0	2ENUW@1|root,33GFZ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
HFD3_k127_2694091_2	1122197.ATWI01000012_gene491	2.925e-23	105.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,468FQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_2694091_0	429009.Adeg_0177	6.938e-192	627.0	COG1067@1|root,COG1674@1|root,COG1067@2|Bacteria,COG1674@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42FSR@68295|Thermoanaerobacterales	186801|Clostridia	O	Endopeptidase La	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
HFD3_k127_2694091_4	1354722.JQLS01000008_gene651	5.064e-10	64.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria,46R0X@74030|Roseovarius	28211|Alphaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	dskA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD3_k127_2694091_1	1173263.Syn7502_03004	4.74e-50	190.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_2695481_16	562970.Btus_1285	7.678e-11	66.0	COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes,4HDDV@91061|Bacilli	91061|Bacilli	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_2695481_18	457396.CSBG_00873	4.603e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,1VD8Q@1239|Firmicutes,24JY7@186801|Clostridia,36K1K@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_2695481_2	387631.Asulf_01856	1.209e-104	363.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota	28890|Euryarchaeota	C	aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HFD3_k127_2695481_1	1336243.JAEA01000010_gene3537	1.686e-122	413.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,1JRKY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	mdlC	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_2695481_4	189426.PODO_11600	3.651e-74	265.0	COG0826@1|root,COG0826@2|Bacteria,1UYPK@1239|Firmicutes,4HW2A@91061|Bacilli,26WVP@186822|Paenibacillaceae	91061|Bacilli	O	Peptidase family U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
HFD3_k127_2695481_7	234267.Acid_7805	1.793e-53	191.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD3_k127_2695481_10	1118054.CAGW01000075_gene3261	4.283e-35	147.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2695481_15	1038859.AXAU01000012_gene4237	3.529e-14	83.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,3JW2Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2695481_11	686340.Metal_3029	2.688e-33	129.0	COG1724@1|root,COG1724@2|Bacteria,1P3W9@1224|Proteobacteria,1SSC4@1236|Gammaproteobacteria,1XGPG@135618|Methylococcales	135618|Methylococcales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD3_k127_2695481_13	32057.KB217478_gene6503	1.6e-22	99.0	COG1598@1|root,COG1598@2|Bacteria,1G9I1@1117|Cyanobacteria,1HPTW@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2695481_17	221359.RS9916_39376	5.335e-08	64.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H438@1129|Synechococcus	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HFD3_k127_2695481_5	350054.Mflv_0673	8.322e-72	255.0	COG0329@1|root,COG0329@2|Bacteria,2HN4J@201174|Actinobacteria,23EW4@1762|Mycobacteriaceae	201174|Actinobacteria	EM	PFAM Dihydrodipicolinate synthetase	-	-	4.1.2.34	ko:K11946,ko:K11949	ko00624,ko01100,ko01120,ko01220,map00624,map01100,map01120,map01220	-	R05648,R07713	RC00924,RC00936	ko00000,ko00001,ko01000	-	-	-	DHDPS
HFD3_k127_2695481_6	314287.GB2207_12012	4.286e-61	228.0	2C4IG@1|root,2Z8DE@2|Bacteria,1P2M2@1224|Proteobacteria,1S011@1236|Gammaproteobacteria,1J5ID@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HFD3_k127_2695481_8	1198232.CYCME_1634	4.476e-48	191.0	COG3419@1|root,COG3419@2|Bacteria	2|Bacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilC	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
HFD3_k127_2695481_0	983545.Glaag_3571	6.733e-179	589.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,469ZG@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HFD3_k127_2695481_9	330214.NIDE1725	1.082e-36	152.0	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD3_k127_2695481_3	1242864.D187_006174	7.167e-76	269.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,437S5@68525|delta/epsilon subdivisions,2X314@28221|Deltaproteobacteria,2YTXI@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HFD3_k127_2695481_12	497321.C664_05256	1.877e-30	135.0	2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria,2VN98@28216|Betaproteobacteria,2KVXJ@206389|Rhodocyclales	206389|Rhodocyclales	S	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HFD3_k127_2695481_14	1198232.CYCME_1634	3.384e-20	104.0	COG3419@1|root,COG3419@2|Bacteria	2|Bacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilC	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
HFD3_k127_2697996_6	296591.Bpro_2056	5.12e-25	110.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
HFD3_k127_2697996_2	555779.Dthio_PD1181	5.625e-83	291.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,42NQX@68525|delta/epsilon subdivisions,2WKDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HFD3_k127_2697996_8	1123368.AUIS01000007_gene2802	3.284e-19	91.0	COG2033@1|root,COG2033@2|Bacteria,1QVWP@1224|Proteobacteria,1SE90@1236|Gammaproteobacteria,2ND47@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Sulphur oxidation protein SoxZ	-	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HFD3_k127_2697996_7	639283.Snov_0971	2.391e-23	106.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,3EZRE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HFD3_k127_2697996_5	1037409.BJ6T_61420	1.58e-44	175.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_2697996_1	1126627.BAWE01000004_gene3002	9.907e-96	351.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HFD3_k127_2697996_0	1173027.Mic7113_4161	7.186e-193	643.0	COG2199@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,Response_reg
HFD3_k127_2697996_4	864702.OsccyDRAFT_2543	1.797e-55	198.0	COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria,1HBXB@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_2697996_3	794903.OPIT5_07185	6.837e-61	218.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,46V2T@74201|Verrucomicrobia,3K9RQ@414999|Opitutae	414999|Opitutae	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
HFD3_k127_2705550_27	1173028.ANKO01000030_gene3279	3.251e-39	149.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HFD3_k127_2705550_14	357808.RoseRS_3898	3.519e-91	313.0	COG0673@1|root,COG0673@2|Bacteria,2G7R0@200795|Chloroflexi,377Y3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD3_k127_2705550_30	237368.SCABRO_03088	8.499e-38	155.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD3_k127_2705550_23	1089551.KE386572_gene4426	3.704e-52	203.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,2U12I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD3_k127_2705550_24	1089551.KE386572_gene4426	3.499e-50	199.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,2U12I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD3_k127_2705550_38	1211777.BN77_p2180049	5.585e-13	79.0	COG0673@1|root,COG0673@2|Bacteria,1QIQ6@1224|Proteobacteria,2U430@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HFD3_k127_2705550_9	1198232.CYCME_1450	5.159e-103	350.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,1RXH8@1236|Gammaproteobacteria,4633T@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_34	908937.Prede_1150	1.123e-19	100.0	2DMX9@1|root,32U7V@2|Bacteria,4NQBF@976|Bacteroidetes,2FR04@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2705550_17	251229.Chro_2374	6.884e-82	280.0	COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
HFD3_k127_2705550_20	1380387.JADM01000018_gene3401	2.544e-68	240.0	COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,1XRUJ@135619|Oceanospirillales	135619|Oceanospirillales	Q	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
HFD3_k127_2705550_12	671143.DAMO_2979	2.638e-94	323.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF616,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2,Glyphos_transf,NTP_transf_5
HFD3_k127_2705550_6	643473.KB235930_gene3513	2.671e-116	394.0	COG3386@1|root,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria,1HMYE@1161|Nostocales	1117|Cyanobacteria	G	SMP-30 Gluconolaconase LRE domain protein	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD3_k127_2705550_29	927677.ALVU02000001_gene3540	3.504e-38	162.0	COG0317@1|root,COG0317@2|Bacteria,1GEK3@1117|Cyanobacteria	1117|Cyanobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
HFD3_k127_2705550_25	927677.ALVU02000001_gene3540	7.185e-47	179.0	COG0317@1|root,COG0317@2|Bacteria,1GEK3@1117|Cyanobacteria	1117|Cyanobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
HFD3_k127_2705550_22	748727.CLJU_c38110	7.836e-59	221.0	COG0726@1|root,COG0726@2|Bacteria,1UF17@1239|Firmicutes,24D13@186801|Clostridia,36HGD@31979|Clostridiaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2705550_15	671143.DAMO_2981	2.003e-89	307.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HFD3_k127_2705550_18	671143.DAMO_2981	4.871e-81	283.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HFD3_k127_2705550_16	671143.DAMO_2980	4.524e-89	300.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_2705550_10	118163.Ple7327_2213	2.035e-102	347.0	COG0438@1|root,COG0438@2|Bacteria,1GIUV@1117|Cyanobacteria,3VKMD@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD3_k127_2705550_31	65393.PCC7424_4247	1.069e-36	152.0	COG1216@1|root,COG1216@2|Bacteria,1G346@1117|Cyanobacteria,3KFQB@43988|Cyanothece	1117|Cyanobacteria	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_2705550_32	667014.Thein_1752	2.821e-31	136.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1,Sulfotransfer_3
HFD3_k127_2705550_7	671143.DAMO_2983	1.799e-115	383.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_33	1030157.AFMP01000004_gene1949	2.826e-28	124.0	2CFS3@1|root,32S2D@2|Bacteria,1N23S@1224|Proteobacteria,2U9XJ@28211|Alphaproteobacteria,2K236@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2705550_8	671143.DAMO_2983	1.676e-112	378.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_3	671143.DAMO_2983	1.867e-119	394.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_2	671143.DAMO_2983	2.89e-120	398.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_37	613026.HRAG_00222	1.606e-13	81.0	COG0535@1|root,COG0535@2|Bacteria,1N99K@1224|Proteobacteria,432A4@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HFD3_k127_2705550_5	671143.DAMO_2983	1.616e-117	388.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_36	570967.JMLV01000004_gene495	9.724e-17	90.0	2DVND@1|root,33WHA@2|Bacteria,1RE84@1224|Proteobacteria,2U817@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2705550_35	1003200.AXXA_13969	3.897e-19	96.0	COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2VZBS@28216|Betaproteobacteria,3T8SH@506|Alcaligenaceae	28216|Betaproteobacteria	M	NAD(P)H-binding	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
HFD3_k127_2705550_13	671143.DAMO_2980	2.989e-94	315.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_2705550_19	932678.THERU_04040	5.35e-78	273.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD3_k127_2705550_26	266117.Rxyl_2350	2.33e-42	165.0	COG4424@1|root,COG4424@2|Bacteria,2GNGY@201174|Actinobacteria	201174|Actinobacteria	S	carbohydrate metabolic process	stf0	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009311,GO:0009987,GO:0016020,GO:0016740,GO:0016782,GO:0017076,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044272,GO:0044281,GO:0044464,GO:0046483,GO:0046505,GO:0046506,GO:0046983,GO:0050427,GO:0050656,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901681	2.8.2.37	ko:K21014	-	-	-	-	ko00000,ko01000	-	-	-	Sulphotransf
HFD3_k127_2705550_21	485917.Phep_3106	5.065e-61	233.0	2DBPQ@1|root,2ZAAD@2|Bacteria,4NJBX@976|Bacteroidetes,1ISIB@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2705550_4	671143.DAMO_2983	6.966e-118	390.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_1	671143.DAMO_2983	3.469e-126	415.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.11,2.4.1.345	ko:K08256,ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292,R11702	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_2705550_0	926569.ANT_26200	1.145e-230	729.0	COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi	200795|Chloroflexi	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_2705550_11	671143.DAMO_2980	5.887e-97	321.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_2706140_2	1038859.AXAU01000025_gene4062	2.129e-11	67.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2TU2B@28211|Alphaproteobacteria,3JQS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_07775	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD3_k127_2706140_3	1535287.JP74_01490	1.304e-08	59.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08580	-	-	-	-	-	-	-	-	-	-	-	Endostatin
HFD3_k127_2706140_1	573064.Mefer_0647	4.388e-15	85.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZE9@28890|Euryarchaeota,23R5U@183939|Methanococci	183939|Methanococci	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_2706140_0	240015.ACP_0475	4.336e-68	245.0	COG3829@1|root,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria,2JHJS@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Sigma54_activat
HFD3_k127_2778078_2	1348657.M622_05010	1.024e-259	829.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2778078_1	1348657.M622_05010	1.093e-260	833.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2778078_0	1348657.M622_05010	8.046e-271	862.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_2778078_3	666510.ASAC_0577	7.431e-10	61.0	COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HFD3_k127_2782754_5	443144.GM21_3745	2.944e-21	94.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD3_k127_2782754_3	671143.DAMO_0075	3.278e-106	354.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HFD3_k127_2782754_1	56780.SYN_02155	1.498e-158	508.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MQ76@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
HFD3_k127_2782754_2	1232410.KI421428_gene1164	1.202e-121	396.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,43SC9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Amino acid kinase family	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HFD3_k127_2782754_0	671143.DAMO_0072	1.766e-194	616.0	COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria	2|Bacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HFD3_k127_2782754_4	1232410.KI421428_gene1166	7.301e-67	230.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,43SFW@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Proteasome subunit	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HFD3_k127_2796060_5	246969.TAM4_600	9.784e-72	247.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota	28890|Euryarchaeota	E	COG3842 ABC-type spermidine putrescine transport systems, ATPase components	-	-	3.6.3.29,3.6.3.30,3.6.3.55	ko:K02010,ko:K02017,ko:K15497	ko02010,map02010	M00189,M00190,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE,TOBE_2
HFD3_k127_2796060_3	105422.BBPM01000113_gene3362	8.634e-103	355.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,2NKS5@228398|Streptacidiphilus	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
HFD3_k127_2796060_9	1231391.AMZF01000003_gene3114	2.547e-21	106.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_2796060_2	671143.DAMO_0649	4.775e-197	634.0	COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K11473,ko:K21834	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,DUF3483,Fer4_8
HFD3_k127_2796060_8	1144310.PMI07_005447	3.289e-53	201.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_2796060_10	1231391.AMZF01000003_gene3114	1.53e-20	103.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_2796060_11	1177594.MIC448_1100027	4.981e-16	89.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2796060_6	643648.Slip_2083	2.928e-68	248.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42KB1@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_2796060_4	671143.DAMO_0647	3.962e-74	262.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfA-5	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD3_k127_2796060_7	552811.Dehly_0968	2.073e-63	226.0	COG2086@1|root,COG2086@2|Bacteria,2G72U@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD3_k127_2796060_1	469383.Cwoe_4084	2.546e-203	648.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	2|Bacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_2796060_0	469383.Cwoe_4085	4.487e-209	671.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_2838948_3	1499684.CCNP01000021_gene2921	7.429e-18	87.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,36WRB@31979|Clostridiaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050,ko:K15554	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	BPD_transp_1
HFD3_k127_2838948_4	765698.Mesci_2875	6.822e-05	54.0	COG0715@1|root,COG0715@2|Bacteria,1MVUJ@1224|Proteobacteria,2U2DS@28211|Alphaproteobacteria,43MG7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2838948_2	1227453.C444_21236	9.685e-79	276.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_2838948_1	323261.Noc_2416	1.535e-81	285.0	COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,1S376@1236|Gammaproteobacteria,1X1QH@135613|Chromatiales	135613|Chromatiales	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HFD3_k127_2838948_0	443143.GM18_1305	1.828e-148	479.0	COG4872@1|root,COG4872@2|Bacteria,1NF4D@1224|Proteobacteria,42XRT@68525|delta/epsilon subdivisions,2WXTA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HFD3_k127_2849479_8	384676.PSEEN2585	2.271e-06	54.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria	1224|Proteobacteria	G	class II Aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD3_k127_2849479_4	1144310.PMI07_005437	3.805e-29	126.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,4BJMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD3_k127_2849479_1	1382356.JQMP01000003_gene1734	3.169e-59	218.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_2849479_0	1134413.ANNK01000086_gene318	1.623e-69	248.0	COG0715@1|root,COG0715@2|Bacteria,1TXP3@1239|Firmicutes,4I6PJ@91061|Bacilli,1ZM9Z@1386|Bacillus	91061|Bacilli	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2849479_2	1530186.JQEY01000017_gene254	7.472e-35	141.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_2849479_6	926560.KE387023_gene2124	4.364e-14	83.0	COG0715@1|root,COG0715@2|Bacteria,1WJPE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2849479_3	997346.HMPREF9374_0830	2.97e-33	138.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,27CII@186824|Thermoactinomycetaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	fadB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD3_k127_2849479_5	706587.Desti_1348	2.731e-18	95.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_2849479_9	1212548.B381_08926	0.0003425	52.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1S3EV@1236|Gammaproteobacteria,1Z0WU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2849479_7	1157638.KB892157_gene1556	4.987e-14	83.0	COG0715@1|root,COG0715@2|Bacteria,2GNMC@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2856244_1	1134413.ANNK01000127_gene2529	1.162e-78	272.0	COG0726@1|root,COG0726@2|Bacteria,1VA2Q@1239|Firmicutes,4HEX3@91061|Bacilli,1ZK98@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_2856244_2	1380394.JADL01000002_gene1445	6.418e-32	137.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_2856244_3	926560.KE387023_gene3325	7.377e-30	132.0	COG1408@1|root,COG1408@2|Bacteria,1WJWG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HFD3_k127_2856244_0	196490.AUEZ01000025_gene2248	2.783e-170	544.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,3JYAZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	1.14.13.1	ko:K00480	ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R05632,R06915,R06936,R06939	RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HFD3_k127_2856244_4	1499967.BAYZ01000184_gene4610	3.499e-09	66.0	COG0642@1|root,COG2205@2|Bacteria,2NQZ3@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD3_k127_2877137_1	1297865.APJD01000026_gene2579	1.085e-83	280.0	2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2TSBD@28211|Alphaproteobacteria,3JT2X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitrile hydratase, alpha chain	nthA	-	4.2.1.84	ko:K01721	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha
HFD3_k127_2877137_0	936455.KI421499_gene2745	3.291e-96	327.0	28I45@1|root,2Z87Q@2|Bacteria,1R432@1224|Proteobacteria,2U3PK@28211|Alphaproteobacteria,3JS7H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	NHase catalyzes the hydration of various nitrile compounds to the corresponding amides	nthB	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
HFD3_k127_2877137_3	1038859.AXAU01000001_gene3289	1.091e-54	194.0	2E3CR@1|root,32YC0@2|Bacteria,1N9Q9@1224|Proteobacteria,2UF5B@28211|Alphaproteobacteria,3JYQP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitrile hydratase beta subunit	MA20_29595	-	-	-	-	-	-	-	-	-	-	-	NHase_beta
HFD3_k127_2877137_4	460265.Mnod_6596	5.347e-32	129.0	COG0454@1|root,COG0456@2|Bacteria,1R8G2@1224|Proteobacteria,2U8TP@28211|Alphaproteobacteria,1JXD6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD3_k127_2877137_2	880073.Calab_3513	2.518e-79	280.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	pip	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Peptidase_S9
HFD3_k127_2911624_1	338963.Pcar_1928	1.685e-170	543.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,43TWM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD3_k127_2911624_16	765912.Thimo_2767	9.116e-21	96.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1WYUA@135613|Chromatiales	135613|Chromatiales	G	Phosphotransferase System	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HFD3_k127_2911624_8	243231.GSU1884	4.915e-91	307.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,43U8A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD3_k127_2911624_13	1125863.JAFN01000001_gene901	2.738e-41	164.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HFD3_k127_2911624_14	1125863.JAFN01000001_gene902	2.018e-22	102.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HFD3_k127_2911624_2	589865.DaAHT2_2206	5.559e-138	454.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD3_k127_2911624_7	1121918.ARWE01000001_gene1888	3.107e-92	309.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,43T7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD3_k127_2911624_18	258594.RPA0048	5.054e-14	79.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,3JTRX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HFD3_k127_2911624_20	1232410.KI421421_gene3585	0.0001459	51.0	COG3117@1|root,COG3117@2|Bacteria,1NJ37@1224|Proteobacteria,42XKQ@68525|delta/epsilon subdivisions,2WSSC@28221|Deltaproteobacteria,43VDN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	lptC	-	-	-	-	-	-	-	-	-	-	-	LptC,OstA
HFD3_k127_2911624_11	795359.TOPB45_0476	4.351e-49	181.0	COG1778@1|root,COG1778@2|Bacteria,2GHR2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase,Hydrolase_3
HFD3_k127_2911624_4	1232410.KI421421_gene3583	6.186e-118	387.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,43S6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	SIS domain	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_1278	CBS,SIS
HFD3_k127_2911624_6	314345.SPV1_09028	1.62e-108	357.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD3_k127_2911624_0	1125863.JAFN01000001_gene910	5.837e-251	784.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
HFD3_k127_2911624_9	926692.AZYG01000040_gene1540	8.856e-81	276.0	COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales	186801|Clostridia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HFD3_k127_2911624_19	32042.PstZobell_01517	1.01e-08	67.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,1RRNG@1236|Gammaproteobacteria,1Z2JM@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2911624_10	1231391.AMZF01000046_gene961	9.238e-52	196.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_2911624_17	1262915.BN574_00676	9.321e-18	93.0	COG4126@1|root,COG4126@2|Bacteria,1V0N4@1239|Firmicutes	1239|Firmicutes	E	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_2911624_12	47839.CCAU010000011_gene5193	6.083e-48	186.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,23625@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_2911624_15	557598.LHK_01006	6.985e-22	104.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VXH1@28216|Betaproteobacteria,2KTE0@206351|Neisseriales	206351|Neisseriales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD3_k127_2911624_5	671143.DAMO_0102	1.04e-110	384.0	COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD3_k127_2911624_3	1232410.KI421428_gene995	2.357e-132	438.0	COG1010@1|root,COG1492@1|root,COG1010@2|Bacteria,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2WJ22@28221|Deltaproteobacteria,43S29@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,Aminotran_1_2,CbiA,GATase_3,TP_methylase
HFD3_k127_2917203_4	56780.SYN_00633	3.44e-27	117.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42RMQ@68525|delta/epsilon subdivisions,2WNRZ@28221|Deltaproteobacteria,2MSK1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Formate dehydrogenase iron-sulfur subunit	fdnH-2	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Form-deh_trans
HFD3_k127_2917203_0	247490.KSU1_C0515	3.948e-144	465.0	COG1063@1|root,COG1063@2|Bacteria,2J2DX@203682|Planctomycetes	203682|Planctomycetes	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_2917203_2	105559.Nwat_0046	3.914e-42	158.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,1S8YK@1236|Gammaproteobacteria,1X28T@135613|Chromatiales	135613|Chromatiales	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD3_k127_2917203_1	1459636.NTE_02180	2.457e-115	377.0	COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
HFD3_k127_2917203_3	517418.Ctha_0715	4.991e-42	167.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_2917203_5	1232410.KI421421_gene3555	2.21e-06	49.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,43SJQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L9, N-terminal domain	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD3_k127_2928124_7	1341151.ASZU01000008_gene1408	8.206e-13	70.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,27AZ9@186824|Thermoactinomycetaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD3_k127_2928124_3	644966.Tmar_2131	5.699e-82	280.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,24HM8@186801|Clostridia,3WDT7@538999|Clostridiales incertae sedis	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_2928124_2	1124780.ANNU01000058_gene886	6.764e-86	291.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,47JUC@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD3_k127_2928124_5	1379698.RBG1_1C00001G0893	3.466e-35	144.0	COG1309@1|root,COG1309@2|Bacteria,2NS0M@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
HFD3_k127_2928124_4	247490.KSU1_C0935	1.136e-53	194.0	COG0450@1|root,COG0450@2|Bacteria,2IZ3M@203682|Planctomycetes	203682|Planctomycetes	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HFD3_k127_2928124_6	1459636.NTE_01426	7.431e-31	131.0	COG1814@1|root,arCOG01096@2157|Archaea,41T13@651137|Thaumarchaeota	651137|Thaumarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HFD3_k127_2928124_1	1379698.RBG1_1C00001G0205	1.29e-100	337.0	COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria	2|Bacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HFD3_k127_2928124_0	1123368.AUIS01000011_gene1180	9.097e-110	364.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD3_k127_2936270_1	443255.SCLAV_5435	8.645e-24	104.0	COG0604@1|root,COG0604@2|Bacteria,2HHQ9@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone reductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HFD3_k127_2936270_2	330214.NIDE1372	2.056e-14	76.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HFD3_k127_2936270_4	525909.Afer_1166	6.635e-09	61.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	relF	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048	-	-	-	PhdYeFM_antitox
HFD3_k127_2936270_0	1267535.KB906767_gene3817	4.308e-49	177.0	COG5611@1|root,COG5611@2|Bacteria	2|Bacteria	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD3_k127_2936270_6	304371.MCP_0721	2.496e-05	49.0	COG2002@1|root,arCOG00815@2157|Archaea	2157|Archaea	K	TIGRFAM transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HFD3_k127_2936270_5	349102.Rsph17025_1926	5.63e-07	61.0	COG0715@1|root,COG0715@2|Bacteria,1N0PZ@1224|Proteobacteria,2U1UN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_2936270_3	491952.Mar181_2011	1.643e-13	78.0	COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,1RZ8H@1236|Gammaproteobacteria,1XN11@135619|Oceanospirillales	135619|Oceanospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2979607_13	1121022.ABENE_11515	6.867e-54	194.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2KGAN@204458|Caulobacterales	204458|Caulobacterales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD3_k127_2979607_0	1463920.JOGB01000064_gene4352	7.92e-188	630.0	COG2931@1|root,COG3291@1|root,COG4409@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	ASH,Big_3_2,F5_F8_type_C,HemolysinCabind,SBBP
HFD3_k127_2979607_2	748449.Halha_0439	3.595e-132	429.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WAI0@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HFD3_k127_2979607_3	555088.DealDRAFT_1732	3.396e-128	418.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HFD3_k127_2979607_9	1307759.JOMJ01000003_gene1221	1.461e-75	265.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,43B4R@68525|delta/epsilon subdivisions,2X5VN@28221|Deltaproteobacteria,2MGWB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_2979607_6	1089553.Tph_c03530	1.961e-87	301.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FXH@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_2979607_12	1219084.AP014508_gene612	2.469e-54	211.0	COG0747@1|root,COG0747@2|Bacteria,2GC3X@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_2979607_7	1370122.JHXQ01000033_gene377	2.399e-84	292.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,4BGVS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF1100,Peptidase_S9
HFD3_k127_2979607_4	261292.Nit79A3_3087	5.792e-115	384.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,2VQZ5@28216|Betaproteobacteria,3720M@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2979607_5	261292.Nit79A3_3087	1.244e-105	357.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,2VQZ5@28216|Betaproteobacteria,3720M@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_2979607_11	443152.MDG893_15015	1.727e-64	229.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,1RNY1@1236|Gammaproteobacteria,46A35@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	KR domain	-	-	1.1.1.304,1.1.1.76	ko:K03366	ko00650,map00650	-	R02855,R02946,R03707,R09078,R10505	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD3_k127_2979607_8	1123060.JONP01000027_gene3502	2.469e-78	272.0	COG0596@1|root,COG0596@2|Bacteria,1N54X@1224|Proteobacteria,2U1C2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD3_k127_2979607_10	928724.SacglDRAFT_01747	2.36e-75	269.0	COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria,4E09H@85010|Pseudonocardiales	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	serA2	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_2979607_14	360911.EAT1b_0261	1.098e-10	68.0	COG1028@1|root,COG1028@2|Bacteria,1TSND@1239|Firmicutes,4HAU2@91061|Bacilli	91061|Bacilli	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_2979607_1	861299.J421_0748	5.215e-152	494.0	COG1505@1|root,COG1505@2|Bacteria,1ZSX7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD3_k127_298839_3	349106.PsycPRwf_0316	6.771e-15	77.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,1SDHP@1236|Gammaproteobacteria,3NSD9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
HFD3_k127_298839_1	1454004.AW11_03982	8.728e-18	91.0	2DZRB@1|root,32VGU@2|Bacteria,1NK4X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_298839_2	1122915.AUGY01000020_gene6479	6.06e-16	86.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_298839_4	1869.MB27_42470	2.815e-05	49.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4DDFQ@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_298839_0	266264.Rmet_4835	2.23e-266	841.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VJKJ@28216|Betaproteobacteria,1K04G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD3_k127_3039638_3	1217718.ALOU01000009_gene1085	5.634e-110	359.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VJEM@28216|Betaproteobacteria,1K31G@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD3_k127_3039638_7	247490.KSU1_B0456	3.163e-61	214.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD3_k127_3039638_0	309807.SRU_0080	8.735e-309	971.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucose isomerase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
HFD3_k127_3039638_2	1382356.JQMP01000003_gene1988	2.514e-128	419.0	COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi,27XH5@189775|Thermomicrobia	189775|Thermomicrobia	C	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD3_k127_3039638_1	357808.RoseRS_2562	4.024e-188	600.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD3_k127_3039638_4	671143.DAMO_0484	7.754e-105	349.0	COG0837@1|root,COG0837@2|Bacteria,2NR7Y@2323|unclassified Bacteria	2|Bacteria	F	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HFD3_k127_3039638_6	247490.KSU1_B0459	1.401e-74	258.0	COG0363@1|root,COG0363@2|Bacteria,2J0I5@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD3_k127_3039638_9	1212548.B381_14431	1.604e-10	73.0	COG0715@1|root,COG0715@2|Bacteria,1N40U@1224|Proteobacteria,1SG8D@1236|Gammaproteobacteria,1Z0AY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_3039638_10	1169143.KB911035_gene2397	2.267e-06	58.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2VSSM@28216|Betaproteobacteria,1K2HQ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_3039638_8	1054860.KB913030_gene4432	4.067e-35	141.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_3039638_5	671143.DAMO_1271	1.086e-89	311.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HFD3_k127_3039638_11	118168.MC7420_2177	1.888e-05	50.0	COG3350@1|root,COG3350@2|Bacteria,1G9KQ@1117|Cyanobacteria,1HG4E@1150|Oscillatoriales	1117|Cyanobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3053877_4	1231391.AMZF01000008_gene1529	2.768e-13	75.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3053877_2	1231391.AMZF01000036_gene2901	2.208e-37	154.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3053877_0	1231391.AMZF01000063_gene1102	6.552e-156	510.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_3053877_1	561175.KB894105_gene943	6.588e-114	377.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EFFE@85012|Streptosporangiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
HFD3_k127_3053877_3	1173263.Syn7502_03004	8.27e-32	137.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_308635_9	1380391.JIAS01000013_gene3476	1.793e-07	57.0	COG3909@1|root,COG3909@2|Bacteria,1N6Z5@1224|Proteobacteria,2VBN2@28211|Alphaproteobacteria,2JUDU@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD3_k127_308635_8	1157490.EL26_03370	1.051e-07	57.0	COG1225@1|root,COG1225@2|Bacteria,1V6MU@1239|Firmicutes,4HK8J@91061|Bacilli,27A0F@186823|Alicyclobacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD3_k127_308635_10	1122621.ATZA01000011_gene414	1.866e-06	52.0	COG1225@1|root,COG1225@2|Bacteria,4NMGU@976|Bacteroidetes,1IS08@117747|Sphingobacteriia	976|Bacteroidetes	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD3_k127_308635_1	1163617.SCD_n00185	2.065e-88	298.0	COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria	28216|Betaproteobacteria	K	transmembrane transcriptional regulator (Anti-sigma factor)	prtR	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_308635_2	1504672.669783772	4.054e-47	175.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,4AE5F@80864|Comamonadaceae	28216|Betaproteobacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	rpoE8	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_308635_0	218284.CCDN010000001_gene1804	2.809e-142	481.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,1ZCMT@1386|Bacillus	91061|Bacilli	S	Penicillin amidase	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HFD3_k127_308635_6	317936.Nos7107_5299	2.232e-28	122.0	COG0625@1|root,COG0625@2|Bacteria,1G4XE@1117|Cyanobacteria,1HJ9S@1161|Nostocales	1117|Cyanobacteria	O	PFAM Glutathione S-transferase, N-terminal	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD3_k127_308635_5	406327.Mevan_1399	1.178e-30	128.0	COG4032@1|root,arCOG01613@2157|Archaea,2XYBY@28890|Euryarchaeota,23QS9@183939|Methanococci	183939|Methanococci	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019295,GO:0019296,GO:0044237,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0050545,GO:0051186,GO:0051188,GO:0071704,GO:1901576	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD3_k127_308635_4	1038860.AXAP01000005_gene8094	2.007e-38	151.0	COG0028@1|root,COG0028@2|Bacteria,1R610@1224|Proteobacteria,2U43S@28211|Alphaproteobacteria,3JTBV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HFD3_k127_308635_3	797210.Halxa_3361	6.791e-45	177.0	COG2141@1|root,arCOG02410@2157|Archaea,2XU72@28890|Euryarchaeota,23S3D@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_308635_7	485913.Krac_2132	1.222e-26	113.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	abmE	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD3_k127_3114054_4	1068980.ARVW01000001_gene860	1.243e-12	70.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria,4E0VD@85010|Pseudonocardiales	201174|Actinobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.50	ko:K12424	-	-	R11608,R11872,R11873	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_3114054_3	1306990.BARG01000042_gene4985	2.745e-31	134.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria	201174|Actinobacteria	Q	beta-lactamase domain protein	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
HFD3_k127_3114054_1	861299.J421_1382	1.501e-39	166.0	COG1228@1|root,COG1228@2|Bacteria,1ZSME@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_3114054_0	1005048.CFU_0645	1.096e-45	172.0	COG4106@1|root,COG4106@2|Bacteria,1QUZE@1224|Proteobacteria,2VSHF@28216|Betaproteobacteria,474Y9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	TPMT
HFD3_k127_3114054_2	1299327.I546_0482	7.8e-33	133.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,234GM@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_3123056_1	338963.Pcar_2900	5.317e-62	219.0	COG0084@1|root,COG0084@2|Bacteria,1R450@1224|Proteobacteria,42WEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD3_k127_3123056_6	935840.JAEQ01000004_gene646	1.789e-26	126.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3123056_4	768704.Desmer_3136	4.157e-58	217.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,26317@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_3123056_3	1207063.P24_04410	1.501e-58	215.0	COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,2JVWG@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_3123056_0	1283283.ATXA01000021_gene2856	3.077e-102	344.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HFD3_k127_3123056_5	330084.JNYZ01000020_gene4708	3.155e-54	205.0	COG1506@1|root,COG1506@2|Bacteria,2I2J3@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Peptidase_S9
HFD3_k127_3123056_2	330214.NIDE0251	1.847e-59	214.0	COG2071@1|root,COG2071@2|Bacteria,3J0PV@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HFD3_k127_3123056_7	1499967.BAYZ01000147_gene728	1.23e-20	94.0	COG0741@1|root,COG4105@1|root,COG0741@2|Bacteria,COG4105@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K06381,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6,TPR_8
HFD3_k127_3136102_7	868595.Desca_0469	2.243e-11	66.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,26269@186807|Peptococcaceae	186801|Clostridia	H	PFAM 5-formyltetrahydrofolate cyclo-ligase	yqgN	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD3_k127_3136102_0	1232410.KI421425_gene1521	1.417e-190	608.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,43SDT@69541|Desulfuromonadales	28221|Deltaproteobacteria	A	Domain of unknown function (DUF3552)	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
HFD3_k127_3136102_2	477974.Daud_1062	9.544e-90	302.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HFD3_k127_3136102_1	525897.Dbac_3373	3.543e-151	488.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2M81M@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HFD3_k127_3136102_3	1382230.ASAP_2763	5.675e-26	108.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3144413_2	251221.35210569	2.822e-96	320.0	COG0573@1|root,COG0573@2|Bacteria,1G1JR@1117|Cyanobacteria	1117|Cyanobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD3_k127_3144413_0	251221.35210568	7.351e-160	509.0	COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria	1117|Cyanobacteria	P	TIGRFAM phosphate binding protein	sphX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
HFD3_k127_3144413_4	706587.Desti_4883	3.398e-88	306.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HFD3_k127_3144413_3	1163617.SCD_n01615	6.94e-94	317.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,2VJNY@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD3_k127_3144413_1	1255043.TVNIR_2412	9.631e-152	493.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WZEX@135613|Chromatiales	135613|Chromatiales	H	DinB superfamily	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
HFD3_k127_3144413_5	525904.Tter_0116	2.345e-65	239.0	COG3525@1|root,COG3525@2|Bacteria,2NPTI@2323|unclassified Bacteria	2|Bacteria	G	beta-N-acetylglucosaminidase	hyl	GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005488,GO:0005515,GO:0005975,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015929,GO:0016231,GO:0016787,GO:0016798,GO:0019538,GO:0030246,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901135,GO:1901564	2.3.1.48,3.2.1.169,3.2.1.35	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	M00076,M00077	R07824,R07825,R09672,R09673,R10905	RC00059,RC00397,RC00451,RC00746	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	GH84	-	F5_F8_type_C,Glyco_hydro_20b,NAGidase
HFD3_k127_3144413_6	335659.S23_39060	5.642e-12	70.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,3JTEW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HFD3_k127_3164700_2	1121428.DESHY_60370___1	6.781e-88	298.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,26160@186807|Peptococcaceae	186801|Clostridia	H	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD3_k127_3164700_3	1536769.P40081_05410	1.681e-53	196.0	COG1335@1|root,COG1335@2|Bacteria,1V2DX@1239|Firmicutes,4HFT9@91061|Bacilli,26V46@186822|Paenibacillaceae	91061|Bacilli	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD3_k127_3164700_1	204669.Acid345_0599	2.89e-123	405.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HFD3_k127_3164700_0	525904.Tter_0334	1.319e-182	590.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NPPN@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD3_k127_3164700_4	1238182.C882_2850	4.575e-19	98.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,2JRR5@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HFD3_k127_3164700_5	1297742.A176_05580	9.775e-11	63.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2YVP9@29|Myxococcales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD3_k127_3176328_0	1499967.BAYZ01000196_gene3073	2.493e-157	507.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HFD3_k127_3176328_4	1156919.QWC_16114	5.028e-29	126.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,3T346@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HFD3_k127_3176328_2	671143.DAMO_0177	5.002e-76	263.0	COG4783@1|root,COG4783@2|Bacteria,2NP4F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD3_k127_3176328_1	323261.Noc_2530	2.478e-78	277.0	COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT,SPOR
HFD3_k127_3176328_3	706587.Desti_3511	3.094e-54	194.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HFD3_k127_3185744_1	1343739.PAP_04900	9.844e-28	122.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	183968|Thermococci	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_3185744_0	1254432.SCE1572_38210	2.407e-47	190.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_3185744_2	68170.KL590487_gene8921	4.947e-21	100.0	2BVHN@1|root,32QW3@2|Bacteria,2IKWS@201174|Actinobacteria,4E5K2@85010|Pseudonocardiales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD3_k127_3187000_2	1041930.Mtc_0756	2.879e-121	401.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HFD3_k127_3187000_7	330214.NIDE3611	8.532e-20	93.0	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
HFD3_k127_3187000_0	323261.Noc_2095	6.439e-308	957.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD3_k127_3187000_8	1123242.JH636435_gene1251	2.788e-19	94.0	COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes	2|Bacteria	T	Universal stress protein	usp-2	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HFD3_k127_3187000_1	880073.Calab_3204	2.185e-133	448.0	COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria	2|Bacteria	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD3_k127_3187000_4	671143.DAMO_1116	1.679e-60	224.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_3187000_6	296591.Bpro_3359	5.637e-33	132.0	COG0527@1|root,COG0527@2|Bacteria,1REUY@1224|Proteobacteria,2VS69@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT,ACT_6
HFD3_k127_3187000_5	1173263.Syn7502_03004	4.495e-33	142.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3187000_3	243233.MCA0498	1.693e-68	239.0	COG4094@1|root,COG4094@2|Bacteria,1RDV6@1224|Proteobacteria,1SAUX@1236|Gammaproteobacteria,1XGC9@135618|Methylococcales	135618|Methylococcales	S	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
HFD3_k127_3187000_9	1094715.CM001373_gene1879	9.592e-08	61.0	COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,1RZXX@1236|Gammaproteobacteria,1JCQQ@118969|Legionellales	118969|Legionellales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,RNase_H_2
HFD3_k127_3192689_10	404589.Anae109_2844	8.516e-25	110.0	2EC6I@1|root,33651@2|Bacteria,1N6AT@1224|Proteobacteria,432YU@68525|delta/epsilon subdivisions,2WXQ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3192689_1	477974.Daud_0866	7.298e-199	641.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD3_k127_3192689_14	321327.CYA_1097	3.222e-06	49.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1GZMN@1129|Synechococcus	1117|Cyanobacteria	G	Alpha amylase, catalytic	-	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HFD3_k127_3192689_2	1173027.Mic7113_2544	3.051e-94	322.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD3_k127_3192689_3	398578.Daci_5074	4.157e-85	297.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HFD3_k127_3192689_11	1123242.JH636435_gene2046	5.46e-22	102.0	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_4,Response_reg
HFD3_k127_3192689_15	247490.KSU1_C0362	0.0003189	45.0	arCOG13241@1|root,2ZEFN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3192689_4	316067.Geob_1640	4.816e-73	251.0	COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD3_k127_3192689_12	1406840.Q763_14925	5.18e-20	94.0	COG0745@1|root,COG0745@2|Bacteria,4NQNT@976|Bacteroidetes,1I3AQ@117743|Flavobacteriia,2NWVA@237|Flavobacterium	976|Bacteroidetes	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_3192689_5	1123392.AQWL01000005_gene2982	1.806e-55	198.0	COG2323@1|root,COG2323@2|Bacteria,1RATW@1224|Proteobacteria,2VTFY@28216|Betaproteobacteria,1KT51@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HFD3_k127_3192689_8	1026882.MAMP_00194	6.828e-38	153.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria,463NP@72273|Thiotrichales	72273|Thiotrichales	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
HFD3_k127_3192689_9	1463841.JOIR01000014_gene1277	4.738e-25	110.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD3_k127_3192689_6	391625.PPSIR1_19949	2.917e-45	181.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
HFD3_k127_3192689_7	247490.KSU1_D0356	1.088e-38	147.0	COG4251@1|root,COG4251@2|Bacteria,2J1P7@203682|Planctomycetes	203682|Planctomycetes	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
HFD3_k127_3192689_0	316067.Geob_3570	9.986e-209	660.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD3_k127_3192689_13	448385.sce7170	1.283e-10	66.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2YZJV@29|Myxococcales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HFD3_k127_3196038_12	246197.MXAN_0378	4.321e-51	186.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2YWVA@29|Myxococcales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HFD3_k127_3196038_21	290317.Cpha266_1949	2.939e-05	48.0	COG3464@1|root,COG3464@2|Bacteria,1FEQP@1090|Chlorobi	1090|Chlorobi	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HFD3_k127_3196038_20	880073.Calab_1795	6.951e-09	56.0	COG3464@1|root,COG3464@2|Bacteria,2NRCT@2323|unclassified Bacteria	2|Bacteria	L	SPTR Transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HFD3_k127_3196038_17	1005058.UMN179_01927	1.104e-13	79.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1Y70J@135625|Pasteurellales	135625|Pasteurellales	M	RTX-III toxin determinant D of Gammaproteobacteria UniRef RepID RTX3D_ACTPL	Z012_10010	-	-	ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HFD3_k127_3196038_8	1125863.JAFN01000001_gene2253	4.051e-73	258.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_3196038_15	1128421.JAGA01000001_gene2387	8.177e-29	127.0	COG4191@1|root,COG4191@2|Bacteria,2NQWP@2323|unclassified Bacteria	2|Bacteria	T	GAF domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HFD3_k127_3196038_22	1218084.BBJK01000096_gene6203	0.0008989	42.0	COG2159@1|root,COG2159@2|Bacteria,1R7NS@1224|Proteobacteria,2WG6X@28216|Betaproteobacteria,1KIAN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HFD3_k127_3196038_13	1440053.JOEI01000005_gene1843	4.984e-45	179.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HFD3_k127_3196038_7	1118054.CAGW01000050_gene1190	3.204e-73	255.0	COG1119@1|root,COG1119@2|Bacteria,1TRR4@1239|Firmicutes,4HB4U@91061|Bacilli,26QE5@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter, ATP-binding protein	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HFD3_k127_3196038_6	913865.DOT_3976	2.795e-78	279.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,2610Z@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3196038_5	1121033.AUCF01000012_gene850	1.54e-88	304.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria,2JSU5@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
HFD3_k127_3196038_11	443144.GM21_3881	5.099e-55	196.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria,43UN0@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HFD3_k127_3196038_10	1131269.AQVV01000039_gene1545	2.16e-56	201.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD3_k127_3196038_2	671143.DAMO_1671	8.214e-131	421.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD3_k127_3196038_4	671143.DAMO_1670	8.57e-96	322.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
HFD3_k127_3196038_1	671143.DAMO_1669	1.512e-219	712.0	COG0845@1|root,COG2010@1|root,COG0845@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,FIVAR,HlyD_3,PA14,RNA_pol_Rpb1_5
HFD3_k127_3196038_9	671143.DAMO_1668	2.252e-71	251.0	COG3794@1|root,COG3794@2|Bacteria,2NR3M@2323|unclassified Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
HFD3_k127_3196038_16	1245475.ANAE01000127_gene606	1.285e-26	118.0	COG0235@1|root,COG0235@2|Bacteria,2IJ2Q@201174|Actinobacteria,4EM7I@85012|Streptosporangiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	ko:K10622	ko00362,ko00622,ko01120,ko01220,map00362,map00622,map01120,map01220	M00539	R02763,R05377	RC00779	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
HFD3_k127_3196038_18	1123368.AUIS01000001_gene2026	1.883e-13	74.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,1STW7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3196038_3	330214.NIDE2455	3.186e-105	357.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	preT	-	1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00528,ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R10159,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3
HFD3_k127_3196038_14	1174528.JH992898_gene3718	2.767e-44	171.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1JIBJ@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_3196038_19	479434.Sthe_1581	1.089e-10	66.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,27XEK@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD3_k127_3196038_0	351607.Acel_1068	0.0	1122.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4ERWG@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD3_k127_3217839_2	1408433.JHXV01000008_gene186	3.398e-53	196.0	COG1215@1|root,COG1215@2|Bacteria,4NJ55@976|Bacteroidetes,1IJK8@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_3217839_3	886293.Sinac_5932	7.024e-28	131.0	2BDT3@1|root,327GV@2|Bacteria,2IZW4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3217839_0	439235.Dalk_1881	5.365e-115	396.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1R092@1224|Proteobacteria,43CRV@68525|delta/epsilon subdivisions,2X7ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_3217839_4	1432055.GLUCORHAEAF1_10375	1.124e-20	94.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria	1224|Proteobacteria	S	Pfam Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HFD3_k127_3217839_1	335543.Sfum_2243	1.458e-59	211.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MQ8C@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HFD3_k127_3217839_5	38654.XP_006027822.1	6.194e-14	77.0	COG0457@1|root,KOG1124@2759|Eukaryota,38F8U@33154|Opisthokonta,3BAQE@33208|Metazoa,3CV5D@33213|Bilateria,4828P@7711|Chordata,4912M@7742|Vertebrata	33208|Metazoa	S	Transmembrane and	TMTC1	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HFD3_k127_3230451_3	246969.TAM4_666	8.263e-31	130.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
HFD3_k127_3230451_1	330214.NIDE3449	7.808e-153	492.0	COG5008@1|root,COG5008@2|Bacteria	2|Bacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD3_k127_3230451_2	330214.NIDE3449	2.535e-148	479.0	COG5008@1|root,COG5008@2|Bacteria	2|Bacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD3_k127_3230451_0	330214.NIDE3448	9.403e-178	562.0	COG2805@1|root,COG2805@2|Bacteria,3J0YS@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HFD3_k127_3230451_4	1536770.R50345_11900	0.0002798	43.0	COG1028@1|root,COG1028@2|Bacteria,1V05R@1239|Firmicutes,4HDCM@91061|Bacilli,26S71@186822|Paenibacillaceae	91061|Bacilli	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	yusR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HFD3_k127_3246395_1	264732.Moth_0731	5.765e-36	147.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24AHX@186801|Clostridia,42FZR@68295|Thermoanaerobacterales	186801|Clostridia	S	Zn-dependent hydrolases of the	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_3246395_3	216596.pRL120671	7.38e-07	61.0	COG0715@1|root,COG0715@2|Bacteria,1R3SJ@1224|Proteobacteria,2VEU8@28211|Alphaproteobacteria,4BATM@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3246395_0	261292.Nit79A3_1589	5.011e-124	411.0	COG2211@1|root,COG2211@2|Bacteria,1NR4C@1224|Proteobacteria,2W1HW@28216|Betaproteobacteria	28216|Betaproteobacteria	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3246395_2	1125863.JAFN01000001_gene1215	3.214e-29	119.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD3_k127_324683_3	1459636.NTE_02626	2.081e-47	180.0	COG2141@1|root,arCOG02410@2157|Archaea	2157|Archaea	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_324683_5	1528106.JRJE01000026_gene55	7.075e-29	120.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria,2JSX2@204441|Rhodospirillales	204441|Rhodospirillales	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD3_k127_324683_1	1220534.B655_0941	1.189e-59	224.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HFD3_k127_324683_6	1282362.AEAC466_11350	1.047e-19	98.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TSFM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
HFD3_k127_324683_0	543913.D521_0540	4.238e-219	689.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_324683_4	316057.RPD_2025	2.35e-41	156.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
HFD3_k127_324683_2	1038859.AXAU01000010_gene1749	1.307e-53	192.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria,3JT2E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_15115	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HFD3_k127_3296409_0	330214.NIDE3359	2.824e-30	128.0	COG2885@1|root,COG2885@2|Bacteria,3J17Q@40117|Nitrospirae	2|Bacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_3307274_2	1190603.AJYD01000028_gene3762	4.673e-06	49.0	COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XT8K@135623|Vibrionales	135623|Vibrionales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Cauli_VI,RNase_H
HFD3_k127_3307274_0	1267533.KB906733_gene2871	4.461e-28	121.0	28QZS@1|root,346UA@2|Bacteria,3Y8H4@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3312262_0	765912.Thimo_1619	0.0	1208.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD3_k127_3312262_2	331678.Cphamn1_1369	3.417e-72	249.0	COG0288@1|root,COG0288@2|Bacteria,1FERE@1090|Chlorobi	1090|Chlorobi	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HFD3_k127_3312262_3	1231391.AMZF01000068_gene2180	1.038e-33	143.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3312262_1	1194972.MVAC_00110	1.959e-86	301.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,237YQ@1762|Mycobacteriaceae	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3317414_7	269799.Gmet_3020	2.547e-51	188.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2WMZE@28221|Deltaproteobacteria,43UMJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HFD3_k127_3317414_11	926556.Echvi_0018	6.075e-24	111.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PDZ@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA,PD40
HFD3_k127_3317414_15	468059.AUHA01000002_gene600	0.0002151	49.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1IQFC@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HFD3_k127_3317414_2	290397.Adeh_2304	1.038e-226	728.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_3317414_8	933115.GPDM_00615	4.714e-42	172.0	COG3573@1|root,COG3573@2|Bacteria,1UY39@1239|Firmicutes,4HBS3@91061|Bacilli,26EBP@186818|Planococcaceae	91061|Bacilli	S	FAD binding domain	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HFD3_k127_3317414_6	1380355.JNIJ01000012_gene1143	1.223e-61	228.0	COG0477@1|root,COG2814@2|Bacteria,1P4XF@1224|Proteobacteria,2U185@28211|Alphaproteobacteria,3JT15@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3317414_14	118166.JH976537_gene228	3.016e-10	65.0	COG1547@1|root,COG1547@2|Bacteria,1G7QG@1117|Cyanobacteria,1HBGH@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HFD3_k127_3317414_1	338963.Pcar_0091	2.49e-301	964.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43SCA@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TRCF	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD3_k127_3317414_9	443143.GM18_0165	2.727e-38	160.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PpiC-type peptidyl-prolyl cis-trans isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HFD3_k127_3317414_5	404380.Gbem_0078	1.927e-98	332.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,43SZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HFD3_k127_3317414_4	667014.Thein_2165	4.614e-162	525.0	COG1109@1|root,COG1109@2|Bacteria,2GHQ7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD3_k127_3317414_0	243231.GSU3325	1.189e-316	998.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,43U3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD3_k127_3317414_3	1382359.JIAL01000001_gene821	2.376e-169	542.0	COG1104@1|root,COG1104@2|Bacteria,3Y3CG@57723|Acidobacteria,2JI55@204432|Acidobacteriia	204432|Acidobacteriia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD3_k127_3317414_10	1201290.M902_1586	3.221e-29	122.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,43ADA@68525|delta/epsilon subdivisions,2MUSB@213481|Bdellovibrionales,2X5SP@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Iron-sulphur cluster biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
HFD3_k127_3317414_13	251221.35211934	9.586e-14	71.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria	1117|Cyanobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD3_k127_3327882_1	909663.KI867150_gene875	1.844e-194	616.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR1E@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714,ko:K07715	ko02020,ko02024,map02020,map02024	M00500,M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_3327882_4	443144.GM21_0541	5.359e-08	57.0	28T91@1|root,2ZFHN@2|Bacteria,1P659@1224|Proteobacteria,433I9@68525|delta/epsilon subdivisions,2WX6G@28221|Deltaproteobacteria,43VY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3327882_2	1173027.Mic7113_0442	3.701e-76	275.0	COG0745@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1G2MH@1117|Cyanobacteria,1H902@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
HFD3_k127_3327882_0	497964.CfE428DRAFT_1952	0.0	2073.0	COG0745@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG3605@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG3605@2|Bacteria,COG5002@2|Bacteria,46Z8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
HFD3_k127_3327882_3	1279015.KB908459_gene2687	3.303e-14	75.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1Y44T@135624|Aeromonadales	135624|Aeromonadales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_3339675_17	1347392.CCEZ01000049_gene1413	9.192e-14	74.0	COG0084@1|root,COG0084@2|Bacteria,1V7QH@1239|Firmicutes,25CNP@186801|Clostridia,36WYE@31979|Clostridiaceae	186801|Clostridia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD3_k127_3339675_0	891968.Anamo_1586	1.068e-256	812.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes	508458|Synergistetes	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
HFD3_k127_3339675_1	891968.Anamo_1584	5.374e-182	576.0	COG0438@1|root,COG0438@2|Bacteria,3TAFG@508458|Synergistetes	508458|Synergistetes	H	PFAM glycosyl transferase group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
HFD3_k127_3339675_10	891968.Anamo_1585	2.926e-62	221.0	COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes	508458|Synergistetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3339675_6	330214.NIDE3401	1.974e-108	362.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	-	-	-	ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HFD3_k127_3339675_8	706587.Desti_1276	7.129e-91	308.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,42S2T@68525|delta/epsilon subdivisions,2WNIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	thuG	-	-	ko:K02026,ko:K10238	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HFD3_k127_3339675_7	706587.Desti_1277	2.134e-100	336.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,42SSV@68525|delta/epsilon subdivisions,2WP8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	thuF	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HFD3_k127_3339675_5	330214.NIDE3398	1.924e-125	415.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	thuE	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
HFD3_k127_3339675_9	330214.NIDE4204	3.365e-65	233.0	COG3769@1|root,COG3769@2|Bacteria	2|Bacteria	S	mannosylglycerate metabolic process	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051	-	R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Hydrolase_3
HFD3_k127_3339675_2	1128421.JAGA01000003_gene2709	2.118e-165	542.0	COG0589@1|root,COG1215@1|root,COG0589@2|Bacteria,COG1215@2|Bacteria,2NNSB@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K09118,ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2,Usp
HFD3_k127_3339675_3	439235.Dalk_2929	3.26e-160	516.0	COG1215@1|root,COG1215@2|Bacteria,1QVA1@1224|Proteobacteria,43BP8@68525|delta/epsilon subdivisions,2X70I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
HFD3_k127_3339675_11	290397.Adeh_3668	1.255e-60	221.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,42UIK@68525|delta/epsilon subdivisions,2X5D2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD3_k127_3339675_15	1123242.JH636435_gene2052	1.224e-42	162.0	COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes	203682|Planctomycetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD3_k127_3339675_16	289376.THEYE_A2098	1.276e-35	143.0	COG2885@1|root,COG2885@2|Bacteria,3J17Q@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_3339675_13	1144310.PMI07_005447	1.206e-47	184.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3339675_4	443152.MDG893_15387	1.671e-138	465.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria,469ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_3339675_14	443152.MDG893_15467	1.446e-43	172.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3339675_12	1144310.PMI07_005447	1.858e-52	199.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3339675_18	1144310.PMI07_001954	0.0007555	45.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3367403_1	1118054.CAGW01000014_gene327	5.097e-10	70.0	COG4126@1|root,COG4126@2|Bacteria,1V0N4@1239|Firmicutes,4HP78@91061|Bacilli	91061|Bacilli	E	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_3367403_0	1191523.MROS_1383	1.519e-128	414.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD3_k127_3374427_5	596154.Alide2_4049	2.931e-07	52.0	COG0318@1|root,COG0318@2|Bacteria,1R6HT@1224|Proteobacteria,2VQR4@28216|Betaproteobacteria,4AH3I@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_3374427_3	180281.CPCC7001_2734	3.283e-15	78.0	2DPNZ@1|root,332U0@2|Bacteria,1GP8W@1117|Cyanobacteria,22TV0@167375|Cyanobium	1117|Cyanobacteria	S	Domain of unknown function (DUF4926)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4926
HFD3_k127_3374427_2	396588.Tgr7_0532	1.616e-34	134.0	COG2161@1|root,COG2161@2|Bacteria,1N8QY@1224|Proteobacteria,1SFWC@1236|Gammaproteobacteria,1X1FU@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD3_k127_3374427_7	1283287.KB822576_gene3895	0.0008264	43.0	COG0596@1|root,COG0596@2|Bacteria,2H1QB@201174|Actinobacteria,4DR46@85009|Propionibacteriales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD3_k127_3374427_6	195253.Syn6312_0833	0.000132	48.0	COG2267@1|root,COG2267@2|Bacteria,1G0CG@1117|Cyanobacteria,1H4C1@1129|Synechococcus	1117|Cyanobacteria	I	Serine aminopeptidase, S33	todF	-	3.7.1.17	ko:K16050	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R09883	RC02018,RC02740	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD3_k127_3374427_4	935848.JAEN01000018_gene349	3.174e-09	68.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,2TRS0@28211|Alphaproteobacteria,2PVJZ@265|Paracoccus	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_3374427_0	1227499.C493_00160	1.878e-56	207.0	COG1116@1|root,arCOG00193@2157|Archaea,2XXDP@28890|Euryarchaeota,23VWW@183963|Halobacteria	183963|Halobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_3374427_1	1202768.JROF01000007_gene2654	2.68e-46	173.0	COG0600@1|root,arCOG00169@2157|Archaea,2XXW6@28890|Euryarchaeota,23WH6@183963|Halobacteria	183963|Halobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_3386619_9	1163617.SCD_n02239	2.176e-14	73.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HFD3_k127_3386619_6	1028307.EAE_04095	5.422e-31	132.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1SYGG@1236|Gammaproteobacteria,3X091@547|Enterobacter	1236|Gammaproteobacteria	C	Catalyzes the reduction of tatronate semialdehyde to D- glycerate	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
HFD3_k127_3386619_0	1454004.AW11_03331	1.071e-143	474.0	COG1226@1|root,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria	1224|Proteobacteria	P	Ion transport 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
HFD3_k127_3386619_7	1122214.AQWH01000003_gene3922	2.013e-20	104.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_3386619_3	189753.AXAS01000041_gene2534	3.426e-81	282.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_3386619_2	1254432.SCE1572_11415	9.446e-113	375.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_3386619_5	1173263.Syn7502_03004	6.642e-33	141.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3386619_8	1028800.RG540_PA09280	1.824e-15	88.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3386619_1	1354722.JQLS01000008_gene1669	1.167e-123	423.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,46PXQ@74030|Roseovarius	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_3386619_4	1267580.AF6_0338	2.079e-33	137.0	COG0388@1|root,COG0388@2|Bacteria,1U0VJ@1239|Firmicutes,4HTZ3@91061|Bacilli	91061|Bacilli	S	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3410312_3	1246484.D479_12598	3.299e-38	153.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HCY5@91061|Bacilli,3NDB9@45667|Halobacillus	91061|Bacilli	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD3_k127_3410312_2	1125973.JNLC01000018_gene2316	1.044e-100	344.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,3K00D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_3410312_1	1125973.JNLC01000018_gene2319	2.961e-104	348.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2U8QU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3410312_0	1125973.JNLC01000018_gene2320	1.214e-206	654.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_3410312_6	1121918.ARWE01000001_gene653	0.0007303	48.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_3410312_4	1380390.JIAT01000014_gene6144	2.264e-28	117.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CPHC@84995|Rubrobacteria	84995|Rubrobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD3_k127_3461443_2	118173.KB235914_gene2444	7.38e-177	583.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HFD3_k127_3461443_1	288000.BBta_7794	1.377e-288	907.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3JTMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD3_k127_3461443_5	1095769.CAHF01000006_gene1884	1.13e-26	114.0	COG0071@1|root,COG0071@2|Bacteria,1N0RH@1224|Proteobacteria,2VVUG@28216|Betaproteobacteria,47820@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HFD3_k127_3461443_0	671143.DAMO_2996	0.0	1028.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HFD3_k127_3461443_4	909613.UO65_0943	2.192e-59	213.0	COG0664@1|root,COG0664@2|Bacteria,2INMI@201174|Actinobacteria,4EBXN@85010|Pseudonocardiales	201174|Actinobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_3461443_3	1121918.ARWE01000001_gene1643	3.575e-118	389.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,42QFN@68525|delta/epsilon subdivisions,2WKUY@28221|Deltaproteobacteria,43UG8@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD3_k127_3484955_2	671143.DAMO_1590	2.01e-46	171.0	COG0755@1|root,COG0755@2|Bacteria,2NPG8@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
HFD3_k127_3484955_3	671143.DAMO_1589	5.251e-33	133.0	COG2332@1|root,COG2332@2|Bacteria	2|Bacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HFD3_k127_3484955_0	635013.TherJR_2282	6.519e-174	567.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,24BV3@186801|Clostridia,26427@186807|Peptococcaceae	186801|Clostridia	O	PFAM Cytochrome C assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD3_k127_3484955_1	671143.DAMO_1587	2.701e-52	191.0	COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin-like	dsbE	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
HFD3_k127_3484955_4	671143.DAMO_1586	2.803e-12	71.0	COG3088@1|root,COG3088@2|Bacteria,2NRBD@2323|unclassified Bacteria	2|Bacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02198,ko:K02200	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmH
HFD3_k127_3510811_6	203119.Cthe_2142	4.923e-52	186.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WHNZ@541000|Ruminococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HFD3_k127_3510811_8	1131269.AQVV01000020_gene2206	2.927e-13	74.0	COG2913@1|root,COG2913@2|Bacteria	2|Bacteria	J	Gram-negative-bacterium-type cell outer membrane assembly	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HFD3_k127_3510811_7	760568.Desku_0316	5.058e-38	164.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,26390@186807|Peptococcaceae	186801|Clostridia	T	Catalyzes the reduction of arsenate As(V) to arsenite As(III)	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HFD3_k127_3510811_2	671143.DAMO_1128	1.798e-107	377.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HFD3_k127_3510811_5	56780.SYN_00981	7.078e-72	249.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657,ko:K07659,ko:K07664,ko:K11329	ko02020,ko02026,map02020,map02026	M00434,M00445,M00450,M00467,M00645,M00646,M00648,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD3_k127_3510811_4	243231.GSU1095	1.782e-83	283.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria,43TYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HFD3_k127_3510811_1	398767.Glov_0621	1.873e-112	371.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,43S92@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD3_k127_3510811_0	243231.GSU1097	3.028e-140	451.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,43RYF@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
HFD3_k127_3510811_3	251221.35210569	3.595e-94	311.0	COG0573@1|root,COG0573@2|Bacteria,1G1JR@1117|Cyanobacteria	1117|Cyanobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD3_k127_3544901_3	887898.HMPREF0551_0308	2.619e-33	130.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,1K3Q4@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	twitching motility protein	pilT	-	-	ko:K02669,ko:K12203	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2,3.A.7.10.1,3.A.7.9.1	-	-	T2SSE
HFD3_k127_3544901_1	68570.DC74_4648	2.161e-55	203.0	COG1028@1|root,COG1028@2|Bacteria,2IDY5@201174|Actinobacteria	201174|Actinobacteria	IQ	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_3544901_0	1380390.JIAT01000009_gene1212	1.08e-144	475.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4CPPX@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10	ko:K00135,ko:K22445	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD3_k127_3544901_2	1194972.MVAC_00110	8.204e-39	154.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,237YQ@1762|Mycobacteriaceae	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3693649_0	856793.MICA_416	1.72e-258	812.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,4BQ2M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
HFD3_k127_3693649_2	856793.MICA_417	1.122e-100	346.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,4BQEN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	MA20_30040	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD3_k127_3693649_3	1500257.JQNM01000007_gene1598	1.472e-19	100.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,4BBDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_3693649_1	675635.Psed_3034	7.042e-112	379.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_3732546_3	1509405.GV67_11100	3.206e-92	313.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,4BCZD@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_3732546_2	1038859.AXAU01000003_gene5873	9.643e-108	366.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,3JXHZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_3732546_4	1380394.JADL01000001_gene2963	4.997e-83	287.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3732546_0	1205680.CAKO01000002_gene3022	1.209e-157	516.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_3732546_1	1121861.KB899913_gene2241	2.77e-109	364.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11	-	-	ABC_tran,TOBE_2
HFD3_k127_3732546_5	313612.L8106_28786	6.83e-46	178.0	COG2755@1|root,COG2755@2|Bacteria,1G8DF@1117|Cyanobacteria,1HFNB@1150|Oscillatoriales	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD3_k127_3732546_6	247490.KSU1_D0617	4.759e-33	139.0	COG1266@1|root,COG1266@2|Bacteria,2J329@203682|Planctomycetes	203682|Planctomycetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HFD3_k127_3747312_7	158189.SpiBuddy_0412	1.907e-06	53.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3747312_4	1231391.AMZF01000046_gene961	2.627e-45	177.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3747312_0	526227.Mesil_1248	3.9e-139	458.0	COG3119@1|root,COG3119@2|Bacteria,1WM9P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	PFAM sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
HFD3_k127_3747312_3	1120949.KB903314_gene304	6.953e-76	268.0	2C1EV@1|root,33RW1@2|Bacteria,2ICZG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3747312_2	795797.C497_16227	1.684e-89	308.0	COG2421@1|root,arCOG01004@2157|Archaea,2XU60@28890|Euryarchaeota,23S6B@183963|Halobacteria	183963|Halobacteria	C	acetamidase formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HFD3_k127_3747312_1	289376.THEYE_A0259	7.85e-90	307.0	COG3829@1|root,COG3829@2|Bacteria,3J0ZQ@40117|Nitrospirae	40117|Nitrospirae	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat
HFD3_k127_3747312_5	1150626.PHAMO_210011	2.659e-24	108.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2JR9I@204441|Rhodospirillales	204441|Rhodospirillales	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD3_k127_3747312_6	991905.SL003B_0706	4.123e-15	78.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
HFD3_k127_3753447_7	1158318.ATXC01000001_gene1391	6.961e-77	264.0	COG0496@1|root,COG0496@2|Bacteria,2G3WU@200783|Aquificae	200783|Aquificae	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD3_k127_3753447_14	754476.Q7A_1890	1.038e-35	139.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,460ZK@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HFD3_k127_3753447_22	204669.Acid345_1281	3.317e-18	86.0	COG0393@1|root,COG0393@2|Bacteria,3Y50H@57723|Acidobacteria,2JJIZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HFD3_k127_3753447_13	368408.Tpen_0524	9.808e-37	147.0	COG0467@1|root,arCOG01171@2157|Archaea,2XRYY@28889|Crenarchaeota	28889|Crenarchaeota	T	Circadian clock protein KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD3_k127_3753447_25	529818.AMSG_03810T0	0.0002803	55.0	COG4886@1|root,KOG0619@2759|Eukaryota	2759|Eukaryota	U	regulation of response to stimulus	-	-	-	ko:K14767,ko:K16175	ko04390,ko04391,ko04530,ko05165,ko05203,map04390,map04391,map04530,map05165,map05203	-	-	-	ko00000,ko00001,ko03009	-	-	-	LRR_6,LRR_8,PDZ,Pkinase_Tyr
HFD3_k127_3753447_12	290397.Adeh_0606	8.483e-45	166.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,4321Z@68525|delta/epsilon subdivisions,2WWZ3@28221|Deltaproteobacteria,2Z0DC@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,Response_reg
HFD3_k127_3753447_10	290397.Adeh_0604	1.607e-47	177.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42THA@68525|delta/epsilon subdivisions,2WNG6@28221|Deltaproteobacteria,2Z32W@29|Myxococcales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HFD3_k127_3753447_1	404589.Anae109_0647	1.799e-163	532.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42Y7C@68525|delta/epsilon subdivisions,2WTJH@28221|Deltaproteobacteria,2YXEJ@29|Myxococcales	28221|Deltaproteobacteria	NT	Chemotaxis protein histidine kinase and related kinases	cheA2	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HFD3_k127_3753447_11	404589.Anae109_0646	4.054e-47	175.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5EQ@28221|Deltaproteobacteria,2Z35B@29|Myxococcales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HFD3_k127_3753447_6	483219.LILAB_28375	5.301e-88	307.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2YX57@29|Myxococcales	28221|Deltaproteobacteria	T	CHASE3 domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal
HFD3_k127_3753447_4	483219.LILAB_28375	5.306e-97	338.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2YX57@29|Myxococcales	28221|Deltaproteobacteria	T	CHASE3 domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal
HFD3_k127_3753447_5	404589.Anae109_0645	5.242e-96	324.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2YX13@29|Myxococcales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR2	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
HFD3_k127_3753447_3	1232410.KI421418_gene2134	7.548e-115	381.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,43S6W@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HFD3_k127_3753447_21	525367.HMPREF0556_11719	1.902e-23	104.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,26KR5@186820|Listeriaceae	91061|Bacilli	NT	Chemotaxis protein CheY	cheY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD3_k127_3753447_19	1122947.FR7_2640	1.812e-26	119.0	COG1406@1|root,COG1406@2|Bacteria,1V46M@1239|Firmicutes,4H54Y@909932|Negativicutes	909932|Negativicutes	N	Chemotaxis phosphatase CheX	-	-	-	-	-	-	-	-	-	-	-	-	CheX
HFD3_k127_3753447_9	266940.Krad_0422	1.534e-66	236.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD3_k127_3753447_0	671143.DAMO_2186	5.764e-169	541.0	COG0148@1|root,COG0148@2|Bacteria,2NNKW@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD3_k127_3753447_24	269799.Gmet_1432	1.214e-12	72.0	COG2919@1|root,COG2919@2|Bacteria,1NM5U@1224|Proteobacteria,42X2K@68525|delta/epsilon subdivisions,2WSPM@28221|Deltaproteobacteria,43VHG@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HFD3_k127_3753447_8	667014.Thein_1148	8.455e-67	236.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD3_k127_3753447_15	986075.CathTA2_3037	2.694e-33	132.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD3_k127_3753447_18	1382306.JNIM01000001_gene3715	3.156e-28	121.0	COG4032@1|root,COG4032@2|Bacteria,2G8KU@200795|Chloroflexi	200795|Chloroflexi	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD3_k127_3753447_20	388467.A19Y_2947	5.642e-25	113.0	COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1G36U@1117|Cyanobacteria,1HFJ5@1150|Oscillatoriales	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
HFD3_k127_3753447_17	1379698.RBG1_1C00001G0547	3e-29	130.0	COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria	2|Bacteria	M	Lipid A biosynthesis	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD3_k127_3753447_16	404589.Anae109_1277	8.411e-31	127.0	COG1959@1|root,COG1959@2|Bacteria,1Q19C@1224|Proteobacteria,4375I@68525|delta/epsilon subdivisions,2WRDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD3_k127_3753447_2	118163.Ple7327_3991	6.164e-155	499.0	COG1104@1|root,COG1104@2|Bacteria,1G0D5@1117|Cyanobacteria,3VIP5@52604|Pleurocapsales	1117|Cyanobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD3_k127_3753447_23	1303518.CCALI_00609	6.205e-18	83.0	COG0719@1|root,COG0719@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
HFD3_k127_3761166_11	941639.BCO26_0244	5.9e-24	104.0	COG0007@1|root,COG0007@2|Bacteria,1TQNH@1239|Firmicutes,4HBB7@91061|Bacilli,1ZBV1@1386|Bacillus	91061|Bacilli	H	Belongs to the precorrin methyltransferase family	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15610	TP_methylase
HFD3_k127_3761166_4	278963.ATWD01000001_gene3712	2.972e-82	283.0	COG1587@1|root,COG2203@1|root,COG1587@2|Bacteria,COG2203@2|Bacteria,3Y68Z@57723|Acidobacteria,2JK7D@204432|Acidobacteriia	204432|Acidobacteriia	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF,GAF_2,HEM4
HFD3_k127_3761166_1	765913.ThidrDRAFT_2798	2.181e-144	463.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1WWQI@135613|Chromatiales	135613|Chromatiales	H	TIGRFAM sulfate adenylyltransferase, small subunit	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD3_k127_3761166_0	498761.HM1_1168	8.344e-273	852.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
HFD3_k127_3761166_12	272134.KB731324_gene3087	4.283e-08	64.0	COG0715@1|root,COG0715@2|Bacteria,1G4RQ@1117|Cyanobacteria,1HEFA@1150|Oscillatoriales	1117|Cyanobacteria	P	COGs COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_3761166_3	1382356.JQMP01000001_gene1198	1.969e-101	351.0	COG0028@1|root,COG0028@2|Bacteria,2GA3W@200795|Chloroflexi,27Z3I@189775|Thermomicrobia	189775|Thermomicrobia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_3761166_9	313606.M23134_08059	1.445e-30	136.0	COG0006@1|root,COG0006@2|Bacteria,4NJI0@976|Bacteroidetes	976|Bacteroidetes	E	xaa-pro dipeptidase K01271	pepQ	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_3761166_7	443152.MDG893_15295	1.932e-52	199.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_3761166_5	512565.AMIS_18720	2.317e-56	205.0	COG0491@1|root,COG0491@2|Bacteria,2GPEX@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_3761166_10	396595.TK90_0224	6.703e-27	112.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1WYTT@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HFD3_k127_3761166_6	306281.AJLK01000105_gene3517	6.648e-54	192.0	COG3791@1|root,COG3791@2|Bacteria,1GAQM@1117|Cyanobacteria,1JKVU@1189|Stigonemataceae	1117|Cyanobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD3_k127_3761166_14	195250.CM001776_gene2132	0.0006973	45.0	298AC@1|root,2ZVFW@2|Bacteria,1GGPS@1117|Cyanobacteria	1117|Cyanobacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD3_k127_3761166_13	32057.KB217483_gene9166	3.09e-07	55.0	2E3CI@1|root,32YBU@2|Bacteria,1GAH6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HFD3_k127_3761166_8	1230476.C207_05739	5.059e-40	151.0	2DP7H@1|root,330V6@2|Bacteria,1R3EB@1224|Proteobacteria,2U01I@28211|Alphaproteobacteria,3JYRG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein (Lin0512_fam)	MA20_27785	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
HFD3_k127_3761166_2	768671.ThimaDRAFT_4428	9.552e-131	426.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HFD3_k127_3767960_7	388051.AUFE01000001_gene2020	6.82e-56	205.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_3767960_5	1207063.P24_18749	1.588e-68	248.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,2JPMC@204441|Rhodospirillales	204441|Rhodospirillales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD3_k127_3767960_4	1283283.ATXA01000021_gene2854	3.184e-88	297.0	COG0235@1|root,COG0235@2|Bacteria,2HGGU@201174|Actinobacteria,4EWNJ@85013|Frankiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_3767960_3	1122915.AUGY01000118_gene6533	6.913e-98	330.0	COG0715@1|root,COG0715@2|Bacteria,1VRJ0@1239|Firmicutes,4HV8W@91061|Bacilli,26U3V@186822|Paenibacillaceae	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3767960_6	671065.MetMK1DRAFT_00016440	6.304e-65	233.0	COG3396@1|root,arCOG04786@2157|Archaea	2157|Archaea	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD3_k127_3767960_2	566461.SSFG_07695	1.777e-108	366.0	COG1541@1|root,COG1541@2|Bacteria,2GP33@201174|Actinobacteria	201174|Actinobacteria	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HFD3_k127_3767960_1	1232410.KI421423_gene1915	1.931e-157	527.0	COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,43V0Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HFD3_k127_3767960_0	388401.RB2150_17917	8.125e-226	731.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3ZI06@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HFD3_k127_3767960_8	1144310.PMI07_005447	6.448e-53	200.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_37706_22	448385.sce7844	5.531e-10	64.0	COG0463@1|root,COG1541@1|root,COG0463@2|Bacteria,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Glycos_transf_2
HFD3_k127_37706_25	1322246.BN4_12062	3.18e-08	64.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HFD3_k127_37706_9	1380390.JIAT01000009_gene1972	3.659e-66	243.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria,4CPQE@84995|Rubrobacteria	84995|Rubrobacteria	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HFD3_k127_37706_6	266117.Rxyl_3164	1.027e-85	293.0	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria,4CQ1N@84995|Rubrobacteria	84995|Rubrobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HFD3_k127_37706_10	1123368.AUIS01000003_gene1752	4.046e-63	222.0	28H8Z@1|root,30SVT@2|Bacteria,1PCCT@1224|Proteobacteria,1SWRM@1236|Gammaproteobacteria,2NDY3@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HFD3_k127_37706_20	1123060.JONP01000017_gene5364	2.333e-14	76.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2UC9K@28211|Alphaproteobacteria,2JY84@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_37706_14	1380355.JNIJ01000011_gene985	2.539e-36	152.0	COG2114@1|root,COG2114@2|Bacteria,1R4VB@1224|Proteobacteria,2TRX8@28211|Alphaproteobacteria,3JWND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HFD3_k127_37706_12	479434.Sthe_0108	2.685e-56	209.0	COG2159@1|root,COG2159@2|Bacteria,2G8UX@200795|Chloroflexi,27Z57@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_37706_16	641524.ADICYQ_3189	1.503e-31	126.0	2E3V1@1|root,32YSA@2|Bacteria,4NV88@976|Bacteroidetes,47S3J@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_37706_11	713586.KB900536_gene627	2.007e-60	211.0	COG0346@1|root,COG0346@2|Bacteria,1RJF9@1224|Proteobacteria,1SAAC@1236|Gammaproteobacteria,1WZ56@135613|Chromatiales	135613|Chromatiales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_37706_4	1348657.M622_07670	2.899e-89	300.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,2WFS6@28216|Betaproteobacteria,2KUWN@206389|Rhodocyclales	206389|Rhodocyclales	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HFD3_k127_37706_2	331869.BAL199_03334	4.439e-113	375.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTMV@28211|Alphaproteobacteria,4BQWG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_37706_15	1005048.CFU_3298	1.391e-32	131.0	COG5580@1|root,COG5580@2|Bacteria,1NMBI@1224|Proteobacteria,2W5GZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD3_k127_37706_1	452637.Oter_0943	3.974e-158	507.0	COG0513@1|root,COG0513@2|Bacteria,46S5M@74201|Verrucomicrobia,3K7N6@414999|Opitutae	414999|Opitutae	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HFD3_k127_37706_3	671143.DAMO_0362	1.704e-109	363.0	COG2837@1|root,COG2837@2|Bacteria	2|Bacteria	P	iron assimilation	dyp	-	-	ko:K07223	-	-	-	-	ko00000	-	-	-	Dyp_perox
HFD3_k127_37706_13	443152.MDG893_15295	7.079e-50	191.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_37706_0	443143.GM18_2405	0.0	1245.0	COG0296@1|root,COG0296@2|Bacteria,1R5YG@1224|Proteobacteria,42S89@68525|delta/epsilon subdivisions,2WNNP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Alpha amylase, C-terminal all-beta domain	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HFD3_k127_37706_21	1217720.ALOX01000011_gene2503	2.584e-13	73.0	COG1502@1|root,COG1502@2|Bacteria,1R4EZ@1224|Proteobacteria,2U0UJ@28211|Alphaproteobacteria,2JXF7@204441|Rhodospirillales	204441|Rhodospirillales	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD3_k127_37706_18	1144325.PMI22_02600	3.749e-29	121.0	COG3686@1|root,COG3686@2|Bacteria,1MZP7@1224|Proteobacteria,1SADS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HFD3_k127_37706_23	1532558.JL39_20250	2.001e-08	59.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HFD3_k127_37706_5	1095769.CAHF01000021_gene943	2.807e-87	292.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2VVC1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD3_k127_37706_24	1227349.C170_10185	2.198e-08	61.0	2DCA4@1|root,2ZDDX@2|Bacteria,1W3V0@1239|Firmicutes,4HZX5@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_37706_7	762376.AXYL_06108	1.056e-69	241.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2VRA6@28216|Betaproteobacteria,3T6CU@506|Alcaligenaceae	28216|Betaproteobacteria	S	Belongs to the LOG family	yvdD_1	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD3_k127_37706_8	522306.CAP2UW1_1340	1.296e-69	242.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HFD3_k127_37706_19	748247.AZKH_0405	4.259e-27	113.0	COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,2WGPE@28216|Betaproteobacteria,2KXA4@206389|Rhodocyclales	206389|Rhodocyclales	G	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
HFD3_k127_37706_26	316056.RPC_1753	0.0004021	47.0	COG2039@1|root,COG2039@2|Bacteria,1MWYG@1224|Proteobacteria,2TU8G@28211|Alphaproteobacteria,3JQYT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	MA20_15835	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
HFD3_k127_3778518_1	945713.IALB_2304	6.601e-49	180.0	2CBKC@1|root,32RTJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3778518_4	1121422.AUMW01000012_gene2937	1.448e-09	60.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,263Z4@186807|Peptococcaceae	186801|Clostridia	C	Acyl-CoA dehydrogenase, N-terminal	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_3778518_0	635013.TherJR_2200	3.443e-62	230.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,2607W@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HFD3_k127_3778518_5	386456.JQKN01000001_gene2361	0.0002018	52.0	arCOG03400@1|root,arCOG03400@2157|Archaea,2XZZ2@28890|Euryarchaeota,23P7G@183925|Methanobacteria	183925|Methanobacteria	S	Nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon,tRNA_anti_2
HFD3_k127_3778518_3	1158318.ATXC01000001_gene581	3.708e-27	117.0	COG1502@1|root,COG1502@2|Bacteria,2G44G@200783|Aquificae	200783|Aquificae	I	SMART phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HFD3_k127_3778518_2	56780.SYN_01765	1.312e-45	182.0	COG1466@1|root,COG1466@2|Bacteria,1RAEB@1224|Proteobacteria,42R0X@68525|delta/epsilon subdivisions,2WMQJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III, delta'	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HFD3_k127_3803715_1	1134912.AJTV01000030_gene2088	4.806e-45	182.0	COG2755@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3291@2|Bacteria,1MYCW@1224|Proteobacteria	1224|Proteobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PA
HFD3_k127_3803715_7	1238186.AOCN01000011_gene1388	5.262e-10	72.0	COG2755@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3291@2|Bacteria,2I8JW@201174|Actinobacteria,4FPT9@85023|Microbacteriaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HFD3_k127_3803715_6	640511.BC1002_4510	1.428e-15	86.0	2EHMJ@1|root,33BDB@2|Bacteria,1RG1S@1224|Proteobacteria,2W287@28216|Betaproteobacteria,1K3X0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
HFD3_k127_3803715_5	1382359.JIAL01000001_gene2542	1.578e-27	118.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria,2JN43@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD3_k127_3803715_2	338963.Pcar_1321	5.508e-40	156.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,43SJX@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF4124)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
HFD3_k127_3803715_3	363253.LI0373	2.605e-39	153.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,2MB0G@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD3_k127_3803715_0	1500894.JQNN01000001_gene3286	1.602e-54	203.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VKYV@28216|Betaproteobacteria,478IY@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Belongs to the phospholipase D family. Cardiolipin synthase subfamily	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD3_k127_3803715_8	404380.Gbem_2013	7.245e-07	51.0	2DQJB@1|root,3377V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3805579_4	1232437.KL661988_gene101	8.532e-11	63.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MHVV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HFD3_k127_3805579_5	1121430.JMLG01000003_gene572	0.0003881	44.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,260JY@186807|Peptococcaceae	186801|Clostridia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HFD3_k127_3805579_0	266779.Meso_2924	1.963e-175	569.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2U2RW@28211|Alphaproteobacteria,43GZZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EH	PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_3805579_3	2045.KR76_02260	3.462e-17	93.0	COG0715@1|root,COG0715@2|Bacteria,2HFTV@201174|Actinobacteria,4DVZY@85009|Propionibacteriales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_3805579_1	631454.N177_0836	1.115e-127	423.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_3805579_2	349102.Rsph17025_2931	9.413e-20	91.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,1FB0J@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_3809036_5	1002809.SSIL_1212	3.931e-09	61.0	COG2128@1|root,COG2128@2|Bacteria,1UVG3@1239|Firmicutes,4HCUC@91061|Bacilli,26EWD@186818|Planococcaceae	91061|Bacilli	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_3809036_4	1033810.HLPCO_002949	6.736e-11	65.0	COG2128@1|root,COG2128@2|Bacteria,2NS09@2323|unclassified Bacteria	2|Bacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_3809036_1	1463821.JOGR01000011_gene2182	2.86e-35	141.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
HFD3_k127_3809036_6	266265.Bxe_C0955	2.639e-05	50.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	1.14.99.57	ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
HFD3_k127_3809036_7	1336245.JAGO01000017_gene1114	0.0001519	53.0	COG0715@1|root,COG0715@2|Bacteria,1QTVG@1224|Proteobacteria,1T3CQ@1236|Gammaproteobacteria,1XKQH@135619|Oceanospirillales	135619|Oceanospirillales	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_3809036_0	1121920.AUAU01000023_gene2399	2.232e-173	549.0	COG0473@1|root,COG0473@2|Bacteria,3Y3YY@57723|Acidobacteria	57723|Acidobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
HFD3_k127_3809036_2	1463821.JOGR01000011_gene2182	8.93e-35	139.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
HFD3_k127_3809036_3	391623.TERMP_00457	2.146e-12	70.0	COG1656@1|root,COG2442@1|root,arCOG04290@2157|Archaea,arCOG07520@2157|Archaea,2Y1HG@28890|Euryarchaeota,244W7@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD3_k127_38095_2	1381123.AYOD01000013_gene2195	4.789e-187	602.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,43I4Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_38095_18	1532558.JL39_17590	4.275e-65	235.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria,4BGNX@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_38095_10	1131269.AQVV01000006_gene529	8.79e-104	346.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	oppB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HFD3_k127_38095_14	1131269.AQVV01000006_gene528	2.48e-75	261.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02034,ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00566	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.2,3.A.1.5.25	-	iAF1260.b1245,iB21_1397.B21_01229,iEC55989_1330.EC55989_1342,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECDH10B_1368.ECDH10B_1307,iECDH1ME8569_1439.ECDH1ME8569_1185,iECD_1391.ECD_01219,iECIAI1_1343.ECIAI1_1264,iECO103_1326.ECO103_1345,iECO111_1330.ECO111_1572,iECO26_1355.ECO26_1756,iECSE_1348.ECSE_1293,iECSP_1301.ECSP_1637,iECUMN_1333.ECUMN_1542,iECW_1372.ECW_m1337,iECs_1301.ECs1745,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcHS_1320.EcHS_A1354,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iJO1366.b1245,iSSON_1240.SSON_1935,iUMNK88_1353.UMNK88_1565,iWFL_1372.ECW_m1337,iY75_1357.Y75_RS06515,iZ_1308.Z2021	BPD_transp_1,OppC_N
HFD3_k127_38095_4	1340493.JNIF01000004_gene702	2.464e-156	510.0	COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria	57723|Acidobacteria	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD3_k127_38095_5	926550.CLDAP_00500	4.841e-156	501.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi	200795|Chloroflexi	HP	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HFD3_k127_38095_17	1121468.AUBR01000014_gene2214	2.05e-67	237.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD3_k127_38095_20	269799.Gmet_1958	1.226e-54	198.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,43US2@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD3_k127_38095_19	338963.Pcar_1299	6.317e-65	231.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,43SVJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD3_k127_38095_6	335543.Sfum_0682	1.068e-135	438.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MQAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD3_k127_38095_16	1485545.JQLW01000009_gene160	2.136e-71	247.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase M50	MA20_27160	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD3_k127_38095_12	96561.Dole_1674	1.458e-84	290.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2MHZH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM tyrosine recombinase XerD	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD3_k127_38095_1	243231.GSU1820	4.516e-218	707.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HFD3_k127_38095_11	96561.Dole_1127	1.601e-92	322.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
HFD3_k127_38095_0	269799.Gmet_1424	8.817e-271	857.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,43TPJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD3_k127_38095_26	1227261.HMPREF0043_00358	8.876e-21	100.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4D3VD@85005|Actinomycetales	201174|Actinobacteria	K	Transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD3_k127_38095_15	1283283.ATXA01000006_gene1854	2.497e-72	255.0	COG3435@1|root,COG3435@2|Bacteria,2GZST@201174|Actinobacteria	201174|Actinobacteria	Q	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_38095_3	246197.MXAN_2289	4.224e-160	518.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,42STW@68525|delta/epsilon subdivisions,2WPBB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD3_k127_38095_25	415426.Hbut_1469	7.975e-23	111.0	COG0624@1|root,arCOG01107@2157|Archaea,2XPWH@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD3_k127_38095_8	158189.SpiBuddy_0414	7.054e-126	423.0	COG1178@1|root,COG1178@2|Bacteria,2J6ND@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_38095_24	525897.Dbac_1842	3.77e-40	162.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria	1224|Proteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_38095_21	525897.Dbac_1842	2.696e-46	184.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria	1224|Proteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_38095_22	316058.RPB_4412	6.728e-46	179.0	COG2141@1|root,COG2141@2|Bacteria,1QGWA@1224|Proteobacteria,2UNBA@28211|Alphaproteobacteria,3K5C8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD3_k127_38095_13	1382306.JNIM01000001_gene1658	1.874e-78	275.0	COG0240@1|root,COG0240@2|Bacteria,2G6HJ@200795|Chloroflexi	200795|Chloroflexi	C	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	-	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
HFD3_k127_38095_7	1382306.JNIM01000001_gene1659	6.5e-126	414.0	COG4948@1|root,COG4948@2|Bacteria,2G704@200795|Chloroflexi	200795|Chloroflexi	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD3_k127_38095_23	756272.Plabr_4336	1.394e-44	165.0	COG0614@1|root,COG0614@2|Bacteria,2J06G@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD3_k127_38095_9	543728.Vapar_6059	1.331e-122	404.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,2VWHW@28216|Betaproteobacteria,4AIJP@80864|Comamonadaceae	28216|Betaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.5.4.44	ko:K15783	ko00260,ko01100,map00260,map01100	-	R09800	RC02661	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_38095_27	1231391.AMZF01000094_gene98	1.079e-14	82.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3822830_2	402777.KB235903_gene588	1.898e-72	254.0	COG2114@1|root,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H988@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768,ko:K03320	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	1.A.11	-	-	DUF3365,Guanylate_cyc,HNOBA,PAS_9
HFD3_k127_3822830_6	519989.ECTPHS_13617	1.46e-07	55.0	COG3311@1|root,COG3311@2|Bacteria,1N72I@1224|Proteobacteria,1SDJ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Excisionase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD3_k127_3822830_0	1121468.AUBR01000023_gene2763	2.183e-208	666.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,42FES@68295|Thermoanaerobacterales	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HFD3_k127_3822830_1	926692.AZYG01000092_gene1703	1.863e-109	368.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,3WB49@53433|Halanaerobiales	186801|Clostridia	H	PFAM MoeA domain protein domain I and II	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HFD3_k127_3822830_7	272569.rrnAC2746	0.0003677	49.0	arCOG02709@1|root,arCOG02709@2157|Archaea,2XXZ2@28890|Euryarchaeota,23W35@183963|Halobacteria	183963|Halobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	glo2	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_3822830_5	387631.Asulf_01856	1.309e-07	57.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota	28890|Euryarchaeota	C	aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HFD3_k127_3822830_3	118166.JH976537_gene516	3.854e-21	102.0	2E5BP@1|root,3303Q@2|Bacteria,1GA0Q@1117|Cyanobacteria,1HG7W@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HFD3_k127_3822830_4	404589.Anae109_3042	1.152e-20	96.0	COG0437@1|root,COG5557@1|root,COG0437@2|Bacteria,COG5557@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,NrfD
HFD3_k127_3832075_1	1380394.JADL01000010_gene4160	3.067e-68	246.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2JZPA@204441|Rhodospirillales	204441|Rhodospirillales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
HFD3_k127_3832075_3	1306990.BARG01000030_gene3383	1.182e-27	126.0	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD3_k127_3832075_0	935840.JAEQ01000023_gene4305	1.688e-200	651.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43J9I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_3832075_2	395965.Msil_3375	6.279e-60	214.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U7NJ@28211|Alphaproteobacteria,3NCF9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_3832075_4	351607.Acel_1472	5.969e-27	124.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3832075_5	1007103.AFHW01000013_gene6162	0.0006973	45.0	COG0477@1|root,COG2814@2|Bacteria,1VSW8@1239|Firmicutes,4HUQC@91061|Bacilli,2773A@186822|Paenibacillaceae	91061|Bacilli	EGP	Belongs to the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_3849044_1	333138.LQ50_20170	3.398e-95	321.0	COG4819@1|root,COG4819@2|Bacteria,1TQ6T@1239|Firmicutes,4HAEM@91061|Bacilli,1ZDKX@1386|Bacillus	91061|Bacilli	E	Ethanolamine utilisation protein EutA	eutA	-	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
HFD3_k127_3849044_2	1120972.AUMH01000002_gene2761	4.994e-88	304.0	2C1EV@1|root,33RW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_3849044_0	1232410.KI421413_gene941	1.335e-134	438.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,43RY0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HFD3_k127_3887196_2	1231391.AMZF01000094_gene98	1.506e-15	82.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3887196_1	1242864.D187_007540	7.539e-28	124.0	COG0451@1|root,COG0451@2|Bacteria,1QX8V@1224|Proteobacteria,43C1V@68525|delta/epsilon subdivisions,2X5FV@28221|Deltaproteobacteria,2YY2H@29|Myxococcales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_3887196_0	1231391.AMZF01000003_gene3114	2.867e-47	183.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3887196_3	583355.Caka_2675	0.0002627	51.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	CP_0991	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HFD3_k127_389013_0	675635.Psed_3034	2.365e-125	417.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_389013_2	348824.LPU83_4145	1.949e-32	128.0	2C19F@1|root,32ZRH@2|Bacteria,1NJ8W@1224|Proteobacteria,2V4D2@28211|Alphaproteobacteria,4BFUV@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_389013_1	572547.Amico_0508	1.096e-32	140.0	COG1099@1|root,COG1099@2|Bacteria,3TC9P@508458|Synergistetes	508458|Synergistetes	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3917708_8	1122915.AUGY01000020_gene6480	1.433e-44	173.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4I4D7@91061|Bacilli,272RG@186822|Paenibacillaceae	1239|Firmicutes	P	Binding-protein-dependent transport system inner membrane component	ssuC	-	-	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
HFD3_k127_3917708_5	1519464.HY22_12475	6.104e-75	267.0	COG2404@1|root,COG2404@2|Bacteria,1FEPM@1090|Chlorobi	1090|Chlorobi	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3917708_1	1382356.JQMP01000003_gene2139	4.495e-141	456.0	COG0686@1|root,COG0686@2|Bacteria,2G68X@200795|Chloroflexi,27YU4@189775|Thermomicrobia	189775|Thermomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD3_k127_3917708_7	177437.HRM2_01080	4.494e-46	169.0	COG2363@1|root,COG2363@2|Bacteria,1PX71@1224|Proteobacteria,434AX@68525|delta/epsilon subdivisions,2X3EE@28221|Deltaproteobacteria,2MP9J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
HFD3_k127_3917708_3	1340434.AXVA01000012_gene2953	1.361e-114	386.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,4HBJ1@91061|Bacilli	91061|Bacilli	C	Conserved carboxylase domain	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_3917708_4	1298860.AUEM01000001_gene1411	1.243e-101	338.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4FRRP@85023|Microbacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_3917708_2	675635.Psed_3034	4.219e-117	395.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_3917708_0	215803.DB30_2329	2.648e-143	486.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1NR2V@1224|Proteobacteria,42YIK@68525|delta/epsilon subdivisions,2WUNG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MV	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_3917708_11	340177.Cag_1039	4.457e-32	132.0	COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi	1090|Chlorobi	M	PFAM OmpA MotB domain protein	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_3917708_12	56780.SYN_03077	8.069e-23	105.0	COG5652@1|root,COG5652@2|Bacteria,1PUUC@1224|Proteobacteria,43F3B@68525|delta/epsilon subdivisions,2X381@28221|Deltaproteobacteria,2MSC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HFD3_k127_3917708_10	331869.BAL199_08898	4.043e-33	143.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3917708_9	1100720.ALKN01000052_gene507	3.628e-44	177.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_3917708_6	1380347.JNII01000009_gene2009	7.146e-71	256.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_3917708_13	1489678.RDMS_03005	7.557e-07	60.0	COG0715@1|root,COG0715@2|Bacteria,1WIC3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC transporter substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_3923276_2	106370.Francci3_0083	4.288e-22	96.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD3_k127_3923276_6	1082933.MEA186_00405	2.171e-10	64.0	COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2TS4X@28211|Alphaproteobacteria,43JVQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_3923276_0	1173021.ALWA01000026_gene2720	1.957e-78	273.0	28JPA@1|root,2Z9FC@2|Bacteria,1G2DB@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3923276_3	671143.DAMO_3115	1.75e-20	94.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD3_k127_3923276_7	1150600.ADIARSV_3090	0.0002323	49.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1IQFC@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HFD3_k127_3923276_4	1121929.KB898662_gene515	2.555e-20	95.0	COG0346@1|root,COG0346@2|Bacteria,1UYR9@1239|Firmicutes	1239|Firmicutes	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759,ko:K08234	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_3923276_1	710686.Mycsm_01832	3.206e-50	191.0	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD3_k127_3923276_5	935557.ATYB01000014_gene2507	6.722e-12	76.0	COG0715@1|root,COG0715@2|Bacteria,1MV9S@1224|Proteobacteria,2TTIU@28211|Alphaproteobacteria,4BB63@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	ssuA	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
HFD3_k127_3923331_8	909663.KI867150_gene1250	1.996e-08	57.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2MR8P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PFAM inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD3_k127_3923331_7	360910.BAV1280	1.201e-08	57.0	COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,2VN1J@28216|Betaproteobacteria,3T7PD@506|Alcaligenaceae	28216|Betaproteobacteria	L	Pfam:DUF3596	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Arm-DNA-bind_2,Phage_int_SAM_3,Phage_integrase
HFD3_k127_3923331_4	351160.RCIX762	1.133e-56	209.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,2NA3A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD3_k127_3923331_1	748247.AZKH_p0041	2.562e-120	392.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD3_k127_3923331_6	1121091.AUMP01000002_gene2194	7.345e-13	79.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	ytlA	GO:0003674,GO:0005215	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_3923331_5	1123504.JQKD01000002_gene3850	6.363e-32	137.0	COG0451@1|root,COG0451@2|Bacteria,1R5DG@1224|Proteobacteria,2VK4B@28216|Betaproteobacteria,4AFHQ@80864|Comamonadaceae	28216|Betaproteobacteria	GM	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_3923331_0	717785.HYPMC_0264	6.381e-123	409.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3923331_3	1415778.JQMM01000001_gene2213	9.255e-62	220.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1J4YB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126,SHOCT
HFD3_k127_3923331_2	234267.Acid_0345	1.247e-84	286.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HFD3_k127_3927013_4	408672.NBCG_01879	9.902e-12	69.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DN8U@85009|Propionibacteriales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
HFD3_k127_3927013_1	1173028.ANKO01000052_gene1669	3.668e-100	334.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,1HA99@1150|Oscillatoriales	1117|Cyanobacteria	E	SMART ATPase, AAA type, core	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
HFD3_k127_3927013_0	1170562.Cal6303_4828	4.396e-164	535.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria,1HJFJ@1161|Nostocales	1117|Cyanobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HFD3_k127_3927013_3	342949.PNA2_1775	7.857e-23	108.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	183968|Thermococci	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_3927013_5	1906.SFRA_14885	7.463e-11	73.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	ssuA_3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_3927013_2	1128421.JAGA01000003_gene2941	7.722e-28	120.0	COG0346@1|root,COG0346@2|Bacteria,2NRR7@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD3_k127_3929170_1	1033802.SSPSH_000980	5.142e-77	272.0	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,1RQQF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides	dho	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD3_k127_3929170_0	491915.Aflv_0216	8.679e-133	434.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H9TQ@91061|Bacilli,21W23@150247|Anoxybacillus	91061|Bacilli	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	-	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HFD3_k127_3929170_2	485913.Krac_0970	8.117e-55	199.0	COG1011@1|root,COG1011@2|Bacteria,2G9RU@200795|Chloroflexi	2|Bacteria	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD3_k127_394115_0	266779.Meso_2926	5.654e-136	448.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_394115_1	426355.Mrad2831_5921	8.139e-11	73.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_3944557_8	1380394.JADL01000004_gene5909	1.399e-85	294.0	COG0346@1|root,COG0346@2|Bacteria,1MX75@1224|Proteobacteria,2TRQS@28211|Alphaproteobacteria,2JVNN@204441|Rhodospirillales	204441|Rhodospirillales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3944557_4	1499967.BAYZ01000176_gene5652	8.57e-106	351.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	ytcB	-	5.1.3.2,5.1.3.6	ko:K01784,ko:K08679	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01385,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD3_k127_3944557_15	891968.Anamo_1477	2.081e-47	180.0	COG0241@1|root,COG0241@2|Bacteria,3TB5N@508458|Synergistetes	508458|Synergistetes	E	1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HFD3_k127_3944557_14	243231.GSU2258	3.838e-48	186.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria,43SX0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HFD3_k127_3944557_9	243231.GSU2259	2.03e-84	295.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,43TBC@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HFD3_k127_3944557_1	56780.SYN_01564	2.629e-189	608.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2MQ69@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD3_k127_3944557_7	472759.Nhal_1230	8.859e-94	320.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales	135613|Chromatiales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HFD3_k127_3944557_6	269799.Gmet_2352	8.008e-95	321.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD3_k127_3944557_11	880072.Desac_2714	3.169e-82	281.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,42P40@68525|delta/epsilon subdivisions,2WK7K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HFD3_k127_3944557_10	1242864.D187_004762	1.832e-83	284.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HFD3_k127_3944557_16	641491.DND132_0624	4.334e-46	171.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2WP3E@28221|Deltaproteobacteria,2MCBA@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HFD3_k127_3944557_5	56780.SYN_01568	1.763e-102	344.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MQC0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HFD3_k127_3944557_18	404589.Anae109_1121	3.263e-16	85.0	COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2YVZ7@29|Myxococcales	28221|Deltaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HFD3_k127_3944557_2	316067.Geob_2097	1.422e-158	530.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,43UEF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD3_k127_3944557_13	56780.SYN_00922	3.609e-73	253.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MQF7@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HFD3_k127_3944557_3	335543.Sfum_3743	6.468e-115	383.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2MQRN@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HFD3_k127_3944557_0	398767.Glov_0757	1.696e-198	629.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD3_k127_3944557_12	869210.Marky_1160	1.73e-81	280.0	COG0685@1|root,COG0685@2|Bacteria,1WI80@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	5,10-methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HFD3_k127_3944557_17	338969.Rfer_3145	5.898e-23	101.0	COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD3_k127_3944557_19	338969.Rfer_3144	2.807e-08	57.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_3950919_0	861299.J421_1876	1.385e-82	278.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HFD3_k127_3950919_1	314285.KT71_01925	7.895e-72	247.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J998@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	SelR domain	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR,TAT_signal
HFD3_k127_3950919_2	1254432.SCE1572_09955	1.003e-53	198.0	28HI5@1|root,2Z7TP@2|Bacteria,1Q2A9@1224|Proteobacteria,437X1@68525|delta/epsilon subdivisions,2X36R@28221|Deltaproteobacteria,2YUJV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3950919_4	472759.Nhal_0811	2.684e-34	136.0	COG4704@1|root,COG4704@2|Bacteria,1N6RE@1224|Proteobacteria,1SGQS@1236|Gammaproteobacteria,1X1KT@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
HFD3_k127_3950919_5	1463885.KL578443_gene1541	3.365e-17	87.0	2FEHJ@1|root,346H3@2|Bacteria,2IQM1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3950919_3	861299.J421_1880	5.305e-50	184.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DM13
HFD3_k127_39588_2	526224.Bmur_0152	1.091e-08	66.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	ssuA	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
HFD3_k127_39588_1	525897.Dbac_1842	3.738e-46	180.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria	1224|Proteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_39588_0	138119.DSY0870	5.305e-95	323.0	COG0596@1|root,COG0596@2|Bacteria,1VVX1@1239|Firmicutes	1239|Firmicutes	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_396016_4	1169161.KB897714_gene6515	5.311e-15	84.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_396016_1	1192034.CAP_0129	9.108e-129	432.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,42SMD@68525|delta/epsilon subdivisions,2WPCI@28221|Deltaproteobacteria,2YW88@29|Myxococcales	28221|Deltaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_396016_3	1173263.Syn7502_03004	8.233e-30	132.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_396016_8	1209984.BN978_03183	0.000876	51.0	COG0715@1|root,COG0715@2|Bacteria,2HT58@201174|Actinobacteria,237V7@1762|Mycobacteriaceae	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_396016_7	1121890.AUDO01000003_gene1723	6.21e-05	48.0	COG0583@1|root,COG0583@2|Bacteria,4NGHS@976|Bacteroidetes,1I0KH@117743|Flavobacteriia,2NTMX@237|Flavobacterium	976|Bacteroidetes	K	Transcriptional regulator	cysL	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD3_k127_396016_0	909663.KI867150_gene31	2.599e-144	472.0	COG0043@1|root,COG0043@2|Bacteria,1Q5FS@1224|Proteobacteria	1224|Proteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_396016_6	1125863.JAFN01000001_gene1353	3.641e-08	59.0	2ENWT@1|root,33GHR@2|Bacteria,1NH7H@1224|Proteobacteria,433DR@68525|delta/epsilon subdivisions,2WXXP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma)	-	-	-	-	-	-	-	-	-	-	-	-	Phenyl_P_gamma
HFD3_k127_396016_2	767817.Desgi_2403	1.276e-87	308.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,261CY@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K00666,ko:K01897,ko:K12507	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_396016_5	47716.JOFH01000004_gene864	5.943e-11	69.0	COG0600@1|root,COG0600@2|Bacteria,2I919@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_3966616_3	1123368.AUIS01000004_gene281	3.621e-23	103.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Iron Permease	efeU_1	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
HFD3_k127_3966616_0	1283300.ATXB01000001_gene433	3.265e-283	888.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1XENN@135618|Methylococcales	135618|Methylococcales	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HFD3_k127_3966616_5	673860.AciM339_0612	0.0005687	47.0	arCOG04939@1|root,arCOG04939@2157|Archaea,2Y76J@28890|Euryarchaeota,3F3H2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	FeoC like transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_3966616_1	330214.NIDE4041	2.422e-71	244.0	COG1592@1|root,COG1592@2|Bacteria,3J0RY@40117|Nitrospirae	40117|Nitrospirae	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HFD3_k127_3966616_2	330214.NIDE4039	9.934e-45	169.0	COG0247@1|root,COG0247@2|Bacteria,3J187@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HFD3_k127_3966616_4	1313265.JNIE01000003_gene1355	1.36e-12	70.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,DUF3501,Fer4_8
HFD3_k127_3969753_13	3641.EOY16574	1.412e-09	61.0	COG0526@1|root,KOG0910@2759|Eukaryota,37U0I@33090|Viridiplantae,3GIAN@35493|Streptophyta	35493|Streptophyta	O	Thioredoxin M-type	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HFD3_k127_3969753_11	1123242.JH636435_gene1758	2.914e-16	80.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_16815	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HFD3_k127_3969753_4	706587.Desti_1031	1.438e-150	486.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585,ko:K07799	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00646,M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6	-	-	HlyD_D23
HFD3_k127_3969753_0	706587.Desti_1032	0.0	1619.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD3_k127_3969753_9	706587.Desti_3800	4.481e-71	246.0	COG1309@1|root,COG1309@2|Bacteria,1NAQF@1224|Proteobacteria,42S96@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD3_k127_3969753_6	1122604.JONR01000015_gene108	3.741e-117	387.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1X5W0@135614|Xanthomonadales	135614|Xanthomonadales	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD3_k127_3969753_1	1449065.JMLL01000010_gene164	7.618e-241	758.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,43IE8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GV	Multidrug ABC transporter ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
HFD3_k127_3969753_3	1122604.JONR01000015_gene110	8.945e-156	504.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3P3@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD3_k127_3969753_2	1122604.JONR01000015_gene111	7.127e-156	501.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,1X52V@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD3_k127_3969753_5	335543.Sfum_0447	1.643e-139	458.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD3_k127_3969753_10	404589.Anae109_3810	3.33e-70	244.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
HFD3_k127_3969753_7	118005.AWNK01000002_gene1737	8.127e-101	334.0	COG0413@1|root,COG0413@2|Bacteria	2|Bacteria	H	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD3_k127_3969753_8	667014.Thein_0298	1.218e-93	314.0	COG0414@1|root,COG0414@2|Bacteria,2GHHM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD3_k127_3969753_12	1101190.ARWB01000001_gene1366	3.113e-16	83.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,36YDT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
HFD3_k127_3970835_4	1038869.AXAN01000048_gene4514	1.448e-15	76.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VZW7@28216|Betaproteobacteria,1K2N1@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamine synthetase	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD3_k127_3970835_1	868864.Dester_0028	2.203e-50	181.0	COG0347@1|root,COG0347@2|Bacteria,2G43N@200783|Aquificae	200783|Aquificae	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD3_k127_3970835_0	76114.ebA5649	2.43e-288	893.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_3970835_2	333138.LQ50_20190	3.843e-30	129.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	araD	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,UPF0066
HFD3_k127_3970835_3	335543.Sfum_0376	2.205e-26	121.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,2MQIP@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD3_k127_3984704_0	883126.HMPREF9710_02598	1.408e-119	404.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD3_k127_3984704_1	485913.Krac_9361	2.175e-116	380.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD3_k127_3994785_8	1380394.JADL01000001_gene2963	1.092e-75	266.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_3994785_18	84531.JMTZ01000025_gene4100	7.408e-13	75.0	2E69S@1|root,330XP@2|Bacteria,1N7XM@1224|Proteobacteria,1SDDI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HFD3_k127_3994785_21	693661.Arcve_0587	7.538e-11	73.0	COG0715@1|root,arCOG01803@2157|Archaea	2157|Archaea	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	Lipoprotein_9,NMT1,NMT1_2,TctC
HFD3_k127_3994785_19	1123023.JIAI01000002_gene4973	2.537e-12	78.0	COG0715@1|root,COG0715@2|Bacteria,2IDBN@201174|Actinobacteria	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_3994785_11	414684.RC1_1514	8.803e-48	184.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,2JVQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_3994785_15	927658.AJUM01000047_gene2790	5.382e-26	120.0	COG1560@1|root,COG1560@2|Bacteria,4NQEF@976|Bacteroidetes,2FXH7@200643|Bacteroidia	976|Bacteroidetes	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD3_k127_3994785_17	113395.AXAI01000014_gene170	1.775e-17	95.0	COG1840@1|root,COG1840@2|Bacteria,1PDYC@1224|Proteobacteria,2TSWW@28211|Alphaproteobacteria,3JX7W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_1,SBP_bac_11,SBP_bac_6
HFD3_k127_3994785_5	395964.KE386496_gene361	4.146e-89	313.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,3NCIH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3994785_7	1120972.AUMH01000002_gene2761	1.308e-76	270.0	2C1EV@1|root,33RW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_3994785_14	1532558.JL39_06940	8.431e-27	124.0	COG1840@1|root,COG1840@2|Bacteria,1PGNJ@1224|Proteobacteria,2V7JA@28211|Alphaproteobacteria,4BDDZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_3994785_16	1532558.JL39_06940	4.839e-24	115.0	COG1840@1|root,COG1840@2|Bacteria,1PGNJ@1224|Proteobacteria,2V7JA@28211|Alphaproteobacteria,4BDDZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_3994785_13	690585.JNNU01000009_gene534	2.876e-29	130.0	COG1840@1|root,COG1840@2|Bacteria,1PGNJ@1224|Proteobacteria,2V7JA@28211|Alphaproteobacteria,4BDDZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_3994785_4	1038858.AXBA01000011_gene1454	5.55e-97	336.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3994785_10	767817.Desgi_3973	8.854e-51	185.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,2627G@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS-like protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_3994785_1	754035.Mesau_02468	3.501e-138	467.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,43H6S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03520	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_3994785_9	767817.Desgi_0753	4.511e-70	252.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_3994785_0	1265310.CCBD010000014_gene3838	9.548e-144	471.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,237YQ@1762|Mycobacteriaceae	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3994785_20	1500301.JQMF01000026_gene2971	3.18e-11	75.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,4BBDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_3994785_6	1194972.MVAC_00110	1.162e-76	275.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,237YQ@1762|Mycobacteriaceae	201174|Actinobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_3994785_3	1097668.BYI23_C003130	4.461e-120	407.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2WBWM@28216|Betaproteobacteria,1K6TM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_3994785_2	1120949.KB903314_gene302	8.477e-126	426.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
HFD3_k127_3994785_12	459495.SPLC1_S080640	1.847e-31	135.0	COG1215@1|root,COG1215@2|Bacteria,1G8C4@1117|Cyanobacteria,1HHUN@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_4003564_4	1089553.Tph_c19760	1.648e-33	139.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_4003564_1	1254432.SCE1572_47310	6.294e-98	330.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD3_k127_4003564_8	1206730.BAGA01000077_gene1036	4.541e-08	63.0	COG3473@1|root,COG3473@2|Bacteria,2GKP7@201174|Actinobacteria,4FU91@85025|Nocardiaceae	201174|Actinobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD3_k127_4003564_7	1123504.JQKD01000005_gene4914	3.453e-08	64.0	COG3473@1|root,COG3473@2|Bacteria,1N3F7@1224|Proteobacteria,2VX2N@28216|Betaproteobacteria,4AJ13@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Catalyzes the conversion of maleate to fumarate	-	-	4.1.1.76,5.2.1.1	ko:K01799,ko:K06033	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_4003564_0	935840.JAEQ01000004_gene650	4.517e-113	375.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2UDPB@28211|Alphaproteobacteria,43J2H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_4003564_2	1173027.Mic7113_2967	1.597e-73	261.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	2|Bacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_4003564_6	717231.Flexsi_0096	2.618e-19	93.0	COG0589@1|root,COG0589@2|Bacteria,2GFI3@200930|Deferribacteres	200930|Deferribacteres	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_4003564_3	1394178.AWOO02000036_gene8905	8.588e-35	139.0	COG5553@1|root,COG5553@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
HFD3_k127_4003564_5	795666.MW7_1558	1.325e-31	130.0	COG2897@1|root,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD3_k127_4005981_3	68194.JNXR01000015_gene7990	8.147e-14	82.0	COG1716@1|root,COG1994@1|root,COG1716@2|Bacteria,COG1994@2|Bacteria,2IBWH@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	AhpC-TSA,FHA,Yop-YscD_cpl,cNMP_binding
HFD3_k127_4005981_2	710696.Intca_0479	3.836e-15	86.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4FFBU@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_4005981_0	272123.Anacy_1312	1.4e-35	141.0	COG0625@1|root,COG0625@2|Bacteria,1G4XE@1117|Cyanobacteria,1HM97@1161|Nostocales	1117|Cyanobacteria	O	PFAM Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HFD3_k127_4022755_3	316067.Geob_3595	3.891e-102	340.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,43TJM@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HFD3_k127_4022755_0	269799.Gmet_1174	1.848e-225	741.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,43T01@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HFD3_k127_4022755_4	290397.Adeh_1905	1.073e-79	271.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales	28221|Deltaproteobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD3_k127_4022755_1	269799.Gmet_3192	5.491e-170	549.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43TM0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD3_k127_4022755_5	1205680.CAKO01000040_gene1081	1.778e-38	150.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_4022755_6	317936.Nos7107_2651	9.152e-35	136.0	COG1669@1|root,COG1669@2|Bacteria,1G8GD@1117|Cyanobacteria,1HNZD@1161|Nostocales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HFD3_k127_4022755_9	1303518.CCALI_01431	1.336e-05	48.0	COG2361@1|root,COG2361@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HFD3_k127_4022755_10	1120973.AQXL01000037_gene601	1.542e-05	50.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07061,ko:K07075	-	-	-	-	ko00000,ko02048	-	-	-	NTP_transf_2
HFD3_k127_4022755_7	1303518.CCALI_00446	2.395e-28	118.0	COG0553@1|root,COG0553@2|Bacteria	2|Bacteria	L	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,SNF2_N
HFD3_k127_4022755_2	1444712.BN1013_02417	3.002e-102	344.0	COG3177@1|root,COG3177@2|Bacteria	2|Bacteria	D	Filamentation induced by cAMP protein fic	fic	-	-	-	-	-	-	-	-	-	-	-	Fic
HFD3_k127_4022755_8	227377.CBU_1788	1.711e-11	66.0	COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,1SPE9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
HFD3_k127_4029691_2	693986.MOC_0225	1.093e-39	164.0	COG0642@1|root,COG2199@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VDSR@28211|Alphaproteobacteria,1JRF8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
HFD3_k127_4029691_0	56780.SYN_00640	4.164e-177	566.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD3_k127_4029691_1	290397.Adeh_4094	2.09e-53	190.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42TKK@68525|delta/epsilon subdivisions,2X5NX@28221|Deltaproteobacteria,2Z0PZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD3_k127_4029691_3	555088.DealDRAFT_2469	4.944e-07	52.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,42KRQ@68298|Syntrophomonadaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD3_k127_4035181_7	1379698.RBG1_1C00001G0806	2.475e-92	309.0	COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_4035181_1	266117.Rxyl_1749	8.665e-156	505.0	COG1012@1|root,COG1012@2|Bacteria,2H1UT@201174|Actinobacteria,4CSB5@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD3_k127_4035181_15	40571.JOEA01000017_gene665	8.492e-08	63.0	COG0346@1|root,COG0346@2|Bacteria,2IIN9@201174|Actinobacteria,4E4EM@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,Glyoxalase
HFD3_k127_4035181_9	443152.MDG893_15467	4.063e-50	192.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4035181_8	985054.JQEZ01000003_gene1509	4.471e-54	207.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_4035181_12	1231391.AMZF01000003_gene3114	6.999e-39	162.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4035181_10	743525.TSC_c11410	3.057e-44	172.0	COG1099@1|root,COG1099@2|Bacteria,1WJGD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4035181_6	661478.OP10G_3558	8.572e-95	319.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
HFD3_k127_4035181_13	469371.Tbis_3122	2.45e-23	107.0	COG0748@1|root,COG0748@2|Bacteria,2HDJB@201174|Actinobacteria,4E4KV@85010|Pseudonocardiales	201174|Actinobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD3_k127_4035181_14	1366050.N234_12150	3.85e-10	70.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K11210	-	-	-	-	ko00000,ko01000	-	-	-	Glyoxalase
HFD3_k127_4035181_0	398525.KB900701_gene7190	8.457e-277	878.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,2TTQP@28211|Alphaproteobacteria,3JU1W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD3_k127_4035181_3	273057.SSO2130	2.204e-128	418.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPVE@28889|Crenarchaeota	28889|Crenarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD3_k127_4035181_2	266117.Rxyl_0920	1.378e-150	486.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HFD3_k127_4035181_5	273057.SSO2128	5.399e-103	348.0	COG1144@1|root,arCOG01604@2157|Archaea,2XRKM@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (PorD-like)	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_21
HFD3_k127_4035181_11	1449126.JQKL01000003_gene1814	3.601e-39	155.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,269C5@186813|unclassified Clostridiales	186801|Clostridia	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HFD3_k127_4035181_4	1120972.AUMH01000002_gene2761	2.077e-113	376.0	2C1EV@1|root,33RW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_4076913_4	99598.Cal7507_0465	1.298e-102	341.0	COG0834@1|root,COG0834@2|Bacteria,1G36J@1117|Cyanobacteria,1HMZA@1161|Nostocales	1117|Cyanobacteria	ET	Amino acid ABC transporter substrate-binding protein, PAAT family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	Ion_trans_2,Lig_chan,SBP_bac_3
HFD3_k127_4076913_3	1192034.CAP_6251	1.291e-108	363.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	1224|Proteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_4076913_5	70601.3257399	6.594e-40	158.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	28890|Euryarchaeota	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_4076913_0	671143.DAMO_0393	2.534e-214	688.0	COG0507@1|root,COG0507@2|Bacteria,2NNQY@2323|unclassified Bacteria	2|Bacteria	L	Helix-hairpin-helix containing domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HFD3_k127_4076913_1	671143.DAMO_2633	1.203e-129	427.0	COG1253@1|root,COG1253@2|Bacteria,2NP04@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699,ko:K06189	-	-	-	-	ko00000,ko02000,ko02042	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21,TerC
HFD3_k127_4076913_6	743299.Acife_1726	8.208e-35	137.0	COG0346@1|root,COG0346@2|Bacteria,1QE9A@1224|Proteobacteria,1SIAS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4076913_2	237368.SCABRO_00778	1.556e-113	376.0	COG0079@1|root,COG0079@2|Bacteria,2IWYA@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_40878_3	526222.Desal_1521	2.402e-59	212.0	COG0765@1|root,COG0765@2|Bacteria,1MVVZ@1224|Proteobacteria,43ADK@68525|delta/epsilon subdivisions,2WNG0@28221|Deltaproteobacteria,2M8YF@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HFD3_k127_40878_4	177437.HRM2_08450	1.003e-58	215.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,43AFA@68525|delta/epsilon subdivisions,2X5V3@28221|Deltaproteobacteria,2MPG7@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
HFD3_k127_40878_1	1121459.AQXE01000011_gene2373	1.073e-105	348.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2M7ZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HFD3_k127_40878_5	671143.DAMO_0142	1.35e-32	132.0	COG2062@1|root,COG2062@2|Bacteria,2NRKX@2323|unclassified Bacteria	2|Bacteria	T	Histidine phosphatase superfamily (branch 1)	sixA	-	3.6.1.55	ko:K03574,ko:K08296	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1
HFD3_k127_40878_0	1380390.JIAT01000009_gene1231	2.994e-206	648.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD3_k127_40878_2	338963.Pcar_2042	4.396e-74	267.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,43S23@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HFD3_k127_4088024_12	234267.Acid_7897	2.372e-36	151.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4088024_14	671143.DAMO_1987	1.233e-23	110.0	COG2259@1|root,COG2259@2|Bacteria,2NQ4C@2323|unclassified Bacteria	2|Bacteria	S	DoxX	ndh	-	1.6.99.3,1.8.5.2	ko:K03885,ko:K16937	ko00190,ko00920,ko01120,map00190,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxD,DoxX,Pyr_redox_2
HFD3_k127_4088024_3	3218.PP1S46_300V6.1	7.88e-96	333.0	COG0667@1|root,2S0PI@2759|Eukaryota,37UGN@33090|Viridiplantae,3GP0T@35493|Streptophyta	35493|Streptophyta	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_4088024_2	661478.OP10G_3558	2.219e-96	325.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
HFD3_k127_4088024_9	1128421.JAGA01000002_gene1306	7.59e-44	165.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD3_k127_4088024_5	323848.Nmul_A2110	5.916e-68	232.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,373GQ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	SelR domain	msrB	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD3_k127_4088024_8	118005.AWNK01000012_gene39	4.23e-54	194.0	COG1666@1|root,COG1666@2|Bacteria	2|Bacteria	S	GTP binding	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HFD3_k127_4088024_16	1042163.BRLA_c039050	1.964e-21	100.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4HD12@91061|Bacilli	91061|Bacilli	S	acetoin utilization protein	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HFD3_k127_4088024_4	329726.AM1_4632	4.144e-71	252.0	COG3735@1|root,COG3735@2|Bacteria,1G6DE@1117|Cyanobacteria	1117|Cyanobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HFD3_k127_4088024_19	31033.ENSTRUP00000040612	5.467e-12	70.0	COG0446@1|root,KOG1336@2759|Eukaryota,38CNG@33154|Opisthokonta,3BH1J@33208|Metazoa,3CTAN@33213|Bilateria,4857Q@7711|Chordata,496S4@7742|Vertebrata,49S39@7898|Actinopterygii	33208|Metazoa	S	apoptosis-inducing factor	AIFM3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005783,GO:0006915,GO:0008150,GO:0008219,GO:0009987,GO:0012501,GO:0012505,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0097194	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
HFD3_k127_4088024_1	392499.Swit_2091	1.663e-116	396.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2U2SV@28211|Alphaproteobacteria,2K9WC@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_4088024_15	768670.Calni_1819	2.617e-23	104.0	COG0517@1|root,COG0517@2|Bacteria,2GEQ8@200930|Deferribacteres	200930|Deferribacteres	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HFD3_k127_4088024_17	1286171.EAL2_c00450	3.974e-14	73.0	COG0695@1|root,COG0695@2|Bacteria,1UF2R@1239|Firmicutes,25NBW@186801|Clostridia,25Z45@186806|Eubacteriaceae	186801|Clostridia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HFD3_k127_4088024_7	690850.Desaf_2413	4.163e-56	207.0	COG1335@1|root,COG1335@2|Bacteria,1REG4@1224|Proteobacteria,42RWA@68525|delta/epsilon subdivisions,2WNB2@28221|Deltaproteobacteria,2MBIG@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_4088024_6	1101190.ARWB01000001_gene117	1.94e-57	211.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,36XKT@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_4088024_11	479434.Sthe_2845	4.979e-40	158.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_4088024_18	1041139.KB902646_gene3338	1.407e-13	81.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,4BBDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_4088024_13	639030.JHVA01000001_gene3069	1.047e-26	115.0	COG1950@1|root,COG1950@2|Bacteria,3Y5FT@57723|Acidobacteria,2JJY4@204432|Acidobacteriia	204432|Acidobacteriia	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HFD3_k127_4088024_0	402881.Plav_2105	1.232e-133	433.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,1JMZZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-I	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HFD3_k127_4088024_10	309801.trd_1809	1.407e-40	162.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_4121151_3	671143.DAMO_2980	2.196e-12	67.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_4121151_0	1340493.JNIF01000003_gene2252	1.335e-112	377.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
HFD3_k127_4121151_1	1261545.MBE-HAL_0633	8.194e-33	137.0	COG0451@1|root,arCOG04704@2157|Archaea,2XU3U@28890|Euryarchaeota,23T3I@183963|Halobacteria	183963|Halobacteria	M	Catalyzes the NAD-dependent oxidation of glucose 6- phosphate to 6-phosphogluconolactone	azf	-	1.1.1.388	ko:K19243	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R10520,R10907	RC00066	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_4121151_2	406552.NJ7G_4277	8.538e-31	130.0	COG0451@1|root,arCOG04704@2157|Archaea,2XU3U@28890|Euryarchaeota,23T3I@183963|Halobacteria	183963|Halobacteria	M	Catalyzes the NAD-dependent oxidation of glucose 6- phosphate to 6-phosphogluconolactone	azf	-	1.1.1.388	ko:K19243	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R10520,R10907	RC00066	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_4121151_6	768672.Desfe_0066	1.611e-05	57.0	COG5650@1|root,arCOG06688@2157|Archaea,2XQA5@28889|Crenarchaeota	28889|Crenarchaeota	S	GPI mannosyltransferase 1 (S. cerevisiae)-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HFD3_k127_4121151_4	1121396.KB893073_gene2960	1.969e-10	72.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,2MK0N@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipid A biosynthesis	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD3_k127_4121151_5	221288.JH992901_gene3390	2.403e-08	64.0	COG1216@1|root,COG1216@2|Bacteria,1GCD3@1117|Cyanobacteria,1JKWV@1189|Stigonemataceae	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HFD3_k127_4134752_1	237368.SCABRO_03159	2.58e-37	158.0	COG3170@1|root,COG3170@2|Bacteria,2J3MN@203682|Planctomycetes	203682|Planctomycetes	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4134752_0	880073.Calab_1818	3.973e-51	192.0	COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HFD3_k127_4152761_6	543632.JOJL01000047_gene3326	1.196e-97	340.0	COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4DJNV@85008|Micromonosporales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_4152761_5	1211114.ALIP01000156_gene3003	3.615e-123	420.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,1X4Z4@135614|Xanthomonadales	135614|Xanthomonadales	M	protein involved in outer membrane biogenesis	asmA	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA
HFD3_k127_4152761_12	1128421.JAGA01000003_gene2880	9.984e-19	97.0	2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria	2|Bacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HFD3_k127_4152761_9	1340493.JNIF01000004_gene143	2.42e-77	265.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD3_k127_4152761_1	234267.Acid_0498	7.512e-281	872.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD3_k127_4152761_3	234267.Acid_0497	9.008e-131	425.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HFD3_k127_4152761_8	886293.Sinac_3660	2.255e-89	304.0	COG1999@1|root,COG1999@2|Bacteria,2IYYD@203682|Planctomycetes	203682|Planctomycetes	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD3_k127_4152761_13	1340493.JNIF01000004_gene147	5.695e-16	84.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4152761_4	1128421.JAGA01000003_gene2874	3.652e-124	409.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4152761_11	204669.Acid345_3000	8.519e-73	252.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_4152761_10	1128421.JAGA01000003_gene2872	1.913e-76	259.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HFD3_k127_4152761_2	1128421.JAGA01000003_gene2871	3.932e-221	692.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HFD3_k127_4152761_0	1128421.JAGA01000003_gene2870	0.0	1213.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmeA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
HFD3_k127_4152761_7	1128421.JAGA01000003_gene2869	1.393e-90	302.0	COG3880@1|root,COG3880@2|Bacteria,2NPCX@2323|unclassified Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrome_C7,GSu_C4xC__C2xCH,UVR
HFD3_k127_4222981_7	1304885.AUEY01000022_gene3406	1.314e-28	116.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MHNG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD3_k127_4222981_5	404589.Anae109_0789	1.758e-46	180.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,42S5S@68525|delta/epsilon subdivisions,2WNSS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Lysin motif	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
HFD3_k127_4222981_3	1123072.AUDH01000002_gene2353	7.286e-98	333.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine synthase	MA20_07800	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_4222981_4	338963.Pcar_1431	1.12e-60	214.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2WP5X@28221|Deltaproteobacteria,43SGN@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoribosyl transferase domain	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HFD3_k127_4222981_6	404589.Anae109_1296	7.69e-46	172.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2WRSP@28221|Deltaproteobacteria,2Z31G@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HFD3_k127_4222981_1	1313301.AUGC01000011_gene1125	1.636e-314	974.0	COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes	976|Bacteroidetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HFD3_k127_4222981_2	243231.GSU2091	1.98e-116	381.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,43UB6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD3_k127_4222981_0	671143.DAMO_1249	0.0	1116.0	COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD3_k127_4225211_12	1231391.AMZF01000046_gene961	2.542e-37	153.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4225211_11	1231391.AMZF01000094_gene98	1.659e-39	160.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4225211_7	1144310.PMI07_005447	8.099e-57	212.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4225211_9	298654.FraEuI1c_2797	2.443e-41	166.0	COG0451@1|root,COG0451@2|Bacteria,2GZ4Z@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_4225211_15	1122915.AUGY01000020_gene6479	1.205e-18	97.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4225211_16	1122915.AUGY01000020_gene6479	1.083e-15	89.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4225211_13	1237149.C900_04906	2.33e-30	124.0	2AFHA@1|root,315HT@2|Bacteria,4NQ5F@976|Bacteroidetes,47VEE@768503|Cytophagia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HFD3_k127_4225211_2	1231391.AMZF01000007_gene1472	1.53e-110	367.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2WF8J@28216|Betaproteobacteria,3T9D4@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_4225211_6	1210884.HG799463_gene10325	3.296e-62	224.0	COG3741@1|root,COG3741@2|Bacteria	2|Bacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4225211_14	1532557.JL37_15780	1.329e-21	104.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,Peptidase_C39_2,TPR_16,TPR_19,TPR_8
HFD3_k127_4225211_4	1231391.AMZF01000003_gene3115	2.911e-87	295.0	COG1028@1|root,COG1028@2|Bacteria,1N3A2@1224|Proteobacteria,2W95G@28216|Betaproteobacteria,3T7RQ@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_4225211_0	479434.Sthe_3255	3.769e-173	555.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,27XWA@189775|Thermomicrobia	200795|Chloroflexi	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD3_k127_4225211_3	520709.F985_00883	3.35e-100	331.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,1S3IM@1236|Gammaproteobacteria,3NST6@468|Moraxellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HFD3_k127_4225211_18	384676.PSEEN2571	5.674e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,1S67S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_4225211_1	1217718.ALOU01000009_gene1072	3.95e-141	458.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN32@28216|Betaproteobacteria	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_4225211_5	202954.BBNK01000005_gene1745	4.248e-66	235.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,1RQQX@1236|Gammaproteobacteria,3NKIM@468|Moraxellaceae	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	hcaA	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	iJN746.PP_3358	ECH_1
HFD3_k127_4225211_8	1231391.AMZF01000069_gene2126	3.006e-55	208.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4225211_10	1231391.AMZF01000094_gene98	6.598e-41	164.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4225211_17	1435356.Y013_22440	1.629e-05	48.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_4228227_0	713586.KB900536_gene1342	6.67e-316	990.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.5.1,1.8.5.3	ko:K00370,ko:K07306,ko:K17050	ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497,R09501	RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.3,5.A.3.8	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HFD3_k127_4228227_3	1125863.JAFN01000001_gene2793	7.416e-87	308.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HFD3_k127_4228227_1	1125863.JAFN01000001_gene2794	4.383e-196	626.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WMNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome b b6 domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD3_k127_4228227_4	1125863.JAFN01000001_gene2795	1.552e-27	120.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HFD3_k127_4228227_2	1125863.JAFN01000001_gene2796	4.325e-97	332.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
HFD3_k127_4236364_3	118168.MC7420_6291	1.067e-30	130.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,1HAC9@1150|Oscillatoriales	1117|Cyanobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_4236364_0	1094980.Mpsy_0698	1.184e-236	743.0	COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD3_k127_4236364_4	1040987.AZUY01000065_gene4154	3.804e-05	53.0	COG4585@1|root,COG4585@2|Bacteria,1R4AM@1224|Proteobacteria,2U0HA@28211|Alphaproteobacteria,43I8A@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD3_k127_4236364_5	344747.PM8797T_08949	7.829e-05	52.0	COG0500@1|root,COG2226@2|Bacteria,2J1BD@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD3_k127_4236364_2	1121106.JQKB01000005_gene2135	1.255e-44	171.0	COG0725@1|root,COG0725@2|Bacteria	2|Bacteria	P	tungstate binding	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HFD3_k127_4236364_1	521674.Plim_0559	1.403e-59	210.0	COG0841@1|root,COG0841@2|Bacteria,2IY6W@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD3_k127_4239106_2	743719.PaelaDRAFT_4778	9.036e-26	115.0	COG4585@1|root,COG4585@2|Bacteria,1TPDG@1239|Firmicutes,4HC7E@91061|Bacilli,26TTZ@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	vraS	-	2.7.13.3	ko:K07681,ko:K11617	ko02020,map02020	M00480,M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
HFD3_k127_4239106_1	1500257.JQNM01000014_gene2912	3.663e-29	128.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_4239106_3	204669.Acid345_3527	1.426e-24	108.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_3527|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4239106_4	1142394.PSMK_22020	4.278e-18	96.0	COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,2IYBJ@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS_4,Response_reg
HFD3_k127_4239106_0	1382306.JNIM01000001_gene1548	3.439e-97	341.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4239367_5	1038869.AXAN01000069_gene597	5.994e-12	69.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,1JZPS@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Gentisate 1,2-dioxygenase	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD3_k127_4239367_6	368408.Tpen_0969	2.271e-06	54.0	COG5550@1|root,arCOG03741@2157|Archaea,2XS67@28889|Crenarchaeota	28889|Crenarchaeota	O	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HFD3_k127_4239367_4	113395.AXAI01000002_gene5235	1.66e-56	209.0	COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,3JWDH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4239367_3	1206744.BAGL01000050_gene955	4.3e-73	257.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria,4G3XZ@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4239367_0	195105.CN97_19055	3.014e-130	435.0	COG0747@1|root,COG0747@2|Bacteria,1MWGY@1224|Proteobacteria,2TR73@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_4239367_1	195105.CN97_19060	4.004e-101	342.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K15585	ko02010,map02010	M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_4239367_2	195105.CN97_19065	1.532e-94	317.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_4272504_0	1232410.KI421415_gene3075	4.701e-155	494.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,43TSW@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD3_k127_4272504_2	443143.GM18_3429	1.036e-84	288.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,43TZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HFD3_k127_4272504_1	909663.KI867150_gene2383	4.016e-85	296.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2MQBB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Mur ligase, middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
HFD3_k127_4331507_1	266265.Bxe_C1059	2.274e-51	187.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,1K3N4@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_4331507_6	632292.Calhy_1551	5.813e-05	55.0	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,42H3Q@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2,Phosphonate-bd
HFD3_k127_4331507_2	379066.GAU_3720	1.102e-49	182.0	28KW4@1|root,2ZACH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4331507_0	189753.AXAS01000041_gene2534	7.052e-77	269.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_4331507_5	1122915.AUGY01000118_gene6536	4.477e-09	68.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4331507_3	1101189.AQUO01000001_gene2036	4.338e-26	117.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2PX1C@265|Paracoccus	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_4408_6	331869.BAL199_16353	3.417e-145	482.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4BPZA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_4408_1	1379281.AVAG01000031_gene106	2.536e-300	950.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
HFD3_k127_4408_11	522306.CAP2UW1_2942	1.115e-112	372.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,1KQM2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HFD3_k127_4408_37	1123060.JONP01000009_gene2150	7.103e-38	154.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2JQCA@204441|Rhodospirillales	204441|Rhodospirillales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_4408_44	861299.J421_3007	5.791e-23	99.0	2EQ8R@1|root,33HV0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4408_5	269799.Gmet_0976	3.508e-152	490.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2WJ57@28221|Deltaproteobacteria,43U6V@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0976	Chorismate_synt
HFD3_k127_4408_39	1392502.JNIO01000008_gene2346	1.635e-33	138.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4H4XC@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HFD3_k127_4408_13	404380.Gbem_1556	2.713e-111	370.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,43TT5@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HFD3_k127_4408_31	111781.Lepto7376_2679	6.588e-51	184.0	COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,1HB2W@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HFD3_k127_4408_56	632335.Calkr_1360	5.356e-06	59.0	COG2304@1|root,COG2304@2|Bacteria,1V5MY@1239|Firmicutes,25BP9@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HFD3_k127_4408_45	862908.BMS_1027	1.076e-22	103.0	COG0848@1|root,COG0848@2|Bacteria,1NE2Q@1224|Proteobacteria,42VAE@68525|delta/epsilon subdivisions,2MTD6@213481|Bdellovibrionales,2WRCE@28221|Deltaproteobacteria	213481|Bdellovibrionales	U	Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD3_k127_4408_41	862908.BMS_1026	2.143e-26	117.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,42TPM@68525|delta/epsilon subdivisions,2WW8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HFD3_k127_4408_57	716928.AJQT01000075_gene141	1.737e-05	56.0	COG0810@1|root,COG0810@2|Bacteria,1RESZ@1224|Proteobacteria,2UBV8@28211|Alphaproteobacteria,4BMTP@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD3_k127_4408_47	1297742.A176_01322	7.804e-21	105.0	COG2849@1|root,COG2849@2|Bacteria,1RJWA@1224|Proteobacteria,42VHV@68525|delta/epsilon subdivisions,2WRR0@28221|Deltaproteobacteria,2Z1RM@29|Myxococcales	28221|Deltaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4408_52	448385.sce3839	1.516e-13	83.0	COG2849@1|root,COG2849@2|Bacteria,1RJWA@1224|Proteobacteria,42VHV@68525|delta/epsilon subdivisions,2WRR0@28221|Deltaproteobacteria,2YVQD@29|Myxococcales	28221|Deltaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4408_26	404380.Gbem_2984	5.569e-61	234.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,43TBY@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HFD3_k127_4408_22	671143.DAMO_3038	2.879e-79	272.0	COG0586@1|root,COG0586@2|Bacteria,2NQ0I@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	dedA	-	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	SNARE_assoc
HFD3_k127_4408_20	883.DvMF_0378	7.43e-81	279.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2M86C@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD3_k127_4408_32	671143.DAMO_2570	1.452e-50	189.0	COG0398@1|root,COG0398@2|Bacteria,2NRVF@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	yjbF	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD3_k127_4408_43	671143.DAMO_1249	1.864e-23	109.0	COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HFD3_k127_4408_23	1173263.Syn7502_03006	1.715e-74	259.0	COG0600@1|root,COG0600@2|Bacteria,1G1ZK@1117|Cyanobacteria,1GZMV@1129|Synechococcus	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_4408_27	1220534.B655_0941	4.221e-57	218.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HFD3_k127_4408_28	502025.Hoch_5030	6.169e-56	204.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,42ZSX@68525|delta/epsilon subdivisions,2WV17@28221|Deltaproteobacteria,2YZ2N@29|Myxococcales	28221|Deltaproteobacteria	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_4408_42	1071073.KI530541_gene3235	1.397e-25	122.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCQN@1386|Bacillus	91061|Bacilli	C	Glycolate oxidase subunit	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iYO844.BSU28680	FAD-oxidase_C,FAD_binding_4
HFD3_k127_4408_58	1382306.JNIM01000001_gene1707	0.0004922	51.0	COG0819@1|root,COG0819@2|Bacteria	2|Bacteria	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	-	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
HFD3_k127_4408_29	1068980.ARVW01000001_gene7255	3.752e-54	203.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
HFD3_k127_4408_16	1125863.JAFN01000001_gene1090	6.174e-96	331.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
HFD3_k127_4408_48	1499967.BAYZ01000159_gene501	1.299e-20	99.0	COG1371@1|root,COG1371@2|Bacteria,2NPX9@2323|unclassified Bacteria	2|Bacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HFD3_k127_4408_38	1117379.BABA_12555	4.447e-37	149.0	COG0494@1|root,COG0494@2|Bacteria,1TYS7@1239|Firmicutes,4I7XB@91061|Bacilli,1ZFQA@1386|Bacillus	91061|Bacilli	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD3_k127_4408_3	861299.J421_3809	1.488e-219	695.0	COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD3_k127_4408_19	671143.DAMO_3017	1.174e-85	291.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	mhpC	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HFD3_k127_4408_40	398767.Glov_2038	1.239e-30	127.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,43TBU@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD3_k127_4408_51	1382359.JIAL01000001_gene1397	4.738e-18	91.0	2CK1C@1|root,32SJA@2|Bacteria,3Y543@57723|Acidobacteria,2JJTF@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4408_21	1121918.ARWE01000001_gene161	1.023e-80	280.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,43S2E@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	YceG-like family	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD3_k127_4408_14	515635.Dtur_0233	5.37e-110	364.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD3_k127_4408_33	1094558.ME5_00733	7.232e-50	190.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_4408_24	671143.DAMO_3119	1.806e-65	235.0	COG1893@1|root,COG1893@2|Bacteria,2NPMG@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD3_k127_4408_34	706587.Desti_0365	8.576e-48	191.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,Fer2,GAF,GAF_2,Guanylate_cyc,Pkinase,Response_reg
HFD3_k127_4408_53	717231.Flexsi_0266	4.4e-10	72.0	COG4191@1|root,COG4191@2|Bacteria,2GFA4@200930|Deferribacteres	200930|Deferribacteres	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD3_k127_4408_8	891968.Anamo_1078	1.386e-122	401.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_4408_4	76114.p2A133	6.916e-156	507.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W317@28216|Betaproteobacteria	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_4408_18	76114.p2A104	1.003e-92	319.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_4408_12	76114.p2A102	6.136e-112	374.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2WFDZ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.15	ko:K07544	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HFD3_k127_4408_9	370438.PTH_1540	4.012e-115	377.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,264MQ@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4408_25	767817.Desgi_3973	7.991e-65	226.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,2627G@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS-like protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_4408_0	767817.Desgi_3972	0.0	1118.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,264EG@186807|Peptococcaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_4408_54	717231.Flexsi_0899	5.514e-09	59.0	COG2331@1|root,COG2331@2|Bacteria,2GG63@200930|Deferribacteres	200930|Deferribacteres	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD3_k127_4408_2	1232410.KI421415_gene3020	4.311e-232	743.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,43THJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
HFD3_k127_4408_30	1121405.dsmv_0325	4.824e-53	208.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2MHRK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1238	Peptidase_M48,TPR_14,TPR_16,TPR_19
HFD3_k127_4408_36	1283283.ATXA01000021_gene2854	6.482e-41	161.0	COG0235@1|root,COG0235@2|Bacteria,2HGGU@201174|Actinobacteria,4EWNJ@85013|Frankiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_4408_15	479434.Sthe_0262	3.702e-96	334.0	COG0402@1|root,COG0402@2|Bacteria,2G8TD@200795|Chloroflexi,27ZAA@189775|Thermomicrobia	189775|Thermomicrobia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_4408_35	996637.SGM_2952	5.212e-43	169.0	COG0451@1|root,COG0451@2|Bacteria,2GZ4Z@201174|Actinobacteria	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_4408_50	859653.HIMB5_00002750	2.312e-19	100.0	COG0006@1|root,COG0006@2|Bacteria,1NTWB@1224|Proteobacteria,2TRKF@28211|Alphaproteobacteria,4BP7H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_4408_46	1122915.AUGY01000020_gene6479	5.099e-22	110.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4408_17	502025.Hoch_4956	4.187e-95	323.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2YU7R@29|Myxococcales	28221|Deltaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD3_k127_4408_7	671143.DAMO_3115	1.072e-139	460.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD3_k127_4408_10	56780.SYN_02371	4.04e-115	377.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD3_k127_4430659_0	187272.Mlg_1646	2.085e-304	948.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales	135613|Chromatiales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HFD3_k127_4430659_7	1110502.TMO_0015	5.198e-09	66.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HFD3_k127_4430659_3	375286.mma_0470	3.643e-148	476.0	COG3181@1|root,COG3181@2|Bacteria,1MW18@1224|Proteobacteria,2VHVS@28216|Betaproteobacteria,472N8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	tctC4	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4430659_5	204773.HEAR0416	9.19e-47	174.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2VT23@28216|Betaproteobacteria,474HM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	tctB4	-	-	-	-	-	-	-	-	-	-	-	TctB
HFD3_k127_4430659_1	204773.HEAR0417	9.958e-235	734.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4729F@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_4430659_6	1173263.Syn7502_03004	5.354e-44	182.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4430659_8	1144310.PMI07_005447	2.343e-06	51.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4430659_2	76114.p2A120	1.064e-195	621.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_4430659_4	1382306.JNIM01000001_gene1379	4.627e-73	261.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	200795|Chloroflexi	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_4446001_6	374847.Kcr_0915	2.2e-82	291.0	arCOG04118@1|root,arCOG04118@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4446001_9	7668.SPU_018748-tr	4.022e-55	202.0	COG0175@1|root,KOG2644@2759|Eukaryota,38HX0@33154|Opisthokonta,3BBJ2@33208|Metazoa,3CRI8@33213|Bilateria	33208|Metazoa	EH	FAD metabolic process	FLAD1	GO:0003674,GO:0003824,GO:0003919,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042726,GO:0042727,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046443,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070566,GO:0071704,GO:0071944,GO:0072387,GO:0072388,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.228,2.7.7.2	ko:K00953,ko:K15429	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00597	RC00002,RC00003,RC00334	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	MoCF_biosynth,PAPS_reduct
HFD3_k127_4446001_2	338966.Ppro_0501	4.776e-131	432.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria,43SUA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
HFD3_k127_4446001_0	1232410.KI421422_gene2063	1.505e-231	732.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43S1W@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HFD3_k127_4446001_25	383372.Rcas_4358	2.756e-11	68.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi,3763C@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_4446001_4	880072.Desac_2413	3.344e-103	347.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,2MR4U@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
HFD3_k127_4446001_13	386456.JQKN01000002_gene2874	4.302e-46	174.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23P0D@183925|Methanobacteria	183925|Methanobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HFD3_k127_4446001_22	1166948.JPZL01000001_gene1933	3.468e-17	94.0	COG2885@1|root,COG2885@2|Bacteria,1RGHU@1224|Proteobacteria,1S5H8@1236|Gammaproteobacteria,1XR3B@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,TSP_3
HFD3_k127_4446001_23	273068.TTE2578	5.324e-16	83.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24U24@186801|Clostridia,42GM9@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_4446001_16	338966.Ppro_0314	9.395e-34	134.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,43V33@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HFD3_k127_4446001_14	1125863.JAFN01000001_gene1069	6.28e-43	162.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-2	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_4446001_28	1038859.AXAU01000006_gene5620	1.962e-05	50.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3JTMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	MA20_45155	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD3_k127_4446001_15	671143.DAMO_2768	5.255e-34	136.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_4446001_24	1201288.M900_0213	1.082e-15	83.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2MTCR@213481|Bdellovibrionales,2WRQ6@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD3_k127_4446001_18	909663.KI867150_gene859	7.641e-30	127.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria,2MREP@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD3_k127_4446001_26	1125863.JAFN01000001_gene2446	4.076e-08	57.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD3_k127_4446001_11	278957.ABEA03000126_gene3738	1.663e-53	203.0	COG3176@1|root,COG3176@2|Bacteria,46Y6I@74201|Verrucomicrobia,3K90P@414999|Opitutae	414999|Opitutae	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
HFD3_k127_4446001_17	1089552.KI911559_gene254	1.056e-31	136.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,2JQPZ@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD3_k127_4446001_29	1382306.JNIM01000001_gene2450	2.564e-05	52.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HFD3_k127_4446001_7	309801.trd_A0566	1.516e-66	237.0	COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4446001_10	1123288.SOV_1c06600	3.819e-54	195.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4H5AR@909932|Negativicutes	909932|Negativicutes	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HFD3_k127_4446001_1	1121935.AQXX01000108_gene413	1.426e-199	626.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1XH2U@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	adhC	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_4446001_12	436229.JOEH01000051_gene6258	1.286e-46	177.0	29J25@1|root,305ZK@2|Bacteria,2IDE0@201174|Actinobacteria	201174|Actinobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HFD3_k127_4446001_21	1532558.JL39_24335	1.041e-25	120.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4446001_5	1200792.AKYF01000020_gene5155	3.923e-103	347.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,4HBKN@91061|Bacilli,26S3I@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD3_k127_4446001_20	316067.Geob_0102	4.748e-27	119.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD3_k127_4446001_19	671143.DAMO_2655	8.18e-29	122.0	COG0720@1|root,COG0720@2|Bacteria,2NR6T@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HFD3_k127_4446001_3	1123060.JONP01000009_gene2150	1.828e-111	366.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2JQCA@204441|Rhodospirillales	204441|Rhodospirillales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_4446001_8	1122918.KB907253_gene3309	5.836e-58	216.0	COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,4HCF8@91061|Bacilli,27516@186822|Paenibacillaceae	91061|Bacilli	C	Aldo/keto reductase family	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_4467351_6	485913.Krac_3757	9.57e-05	46.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HFD3_k127_4467351_0	404380.Gbem_2283	1.412e-174	564.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HFD3_k127_4467351_5	264462.Bd3336	7.205e-08	63.0	COG3087@1|root,COG3087@2|Bacteria	2|Bacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	NYN,SPOR
HFD3_k127_4467351_1	1125863.JAFN01000001_gene2405	2.975e-116	384.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
HFD3_k127_4467351_2	443144.GM21_2259	6.168e-67	241.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,43S5I@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
HFD3_k127_4467351_3	1232410.KI421415_gene3076	3.729e-51	188.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HFD3_k127_4467351_4	1411123.JQNH01000001_gene3644	2.564e-41	156.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD3_k127_4520213_0	1125863.JAFN01000001_gene936	1.451e-197	630.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_4520213_5	879212.DespoDRAFT_01647	4.716e-97	331.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,42M7Q@68525|delta/epsilon subdivisions,2WJ9Z@28221|Deltaproteobacteria,2MIK8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_4520213_8	935863.AWZR01000003_gene2845	2.43e-79	280.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X7Y9@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferases group 1	-	-	-	ko:K21001	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HFD3_k127_4520213_11	757424.Hsero_4200	3.736e-37	160.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,473C1@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	- Amino acid transport and metabolism	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_4520213_6	76114.ebA4291	4.178e-89	302.0	COG2227@1|root,COG2227@2|Bacteria,1QVIA@1224|Proteobacteria,2VWHZ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD3_k127_4520213_14	1349767.GJA_2670	3.593e-08	63.0	COG0457@1|root,COG0457@2|Bacteria,1RIHH@1224|Proteobacteria,2VTBB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2
HFD3_k127_4520213_3	1266925.JHVX01000005_gene1901	4.634e-134	437.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,371UH@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_4520213_9	269799.Gmet_2013	1.1e-45	179.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria,43VFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_4520213_7	1095769.CAHF01000010_gene1304	9.29e-86	297.0	COG5653@1|root,COG5653@2|Bacteria,1RDJC@1224|Proteobacteria,2VS2B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HFD3_k127_4520213_13	351348.Maqu_1633	4.719e-12	77.0	2DSA6@1|root,33F7S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4520213_12	251229.Chro_2371	2.037e-17	86.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP-7	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_4520213_1	59538.XP_005968168.1	1.137e-153	501.0	COG0318@1|root,KOG1176@2759|Eukaryota	2759|Eukaryota	IQ	ligase activity	-	-	6.2.1.8	ko:K18661,ko:K22133	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01558,R03383	RC00004,RC00137,RC00179	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,FSH1,PP-binding
HFD3_k127_4520213_2	935261.JAGL01000053_gene635	9.625e-135	443.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TUK2@28211|Alphaproteobacteria,43MYE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD3_k127_4520213_10	760117.JN27_22025	8.281e-45	178.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5,DegT_DnrJ_EryC1
HFD3_k127_4520213_4	472759.Nhal_2164	3.136e-108	359.0	COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,1RN11@1236|Gammaproteobacteria,1WXWW@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4
HFD3_k127_4526137_0	1123501.KB902290_gene1571	6.156e-152	503.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_4526137_6	1082931.KKY_2644	5.186e-38	152.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_4526137_13	1123501.KB902290_gene1570	0.0001415	48.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_4526137_1	443144.GM21_2878	1.996e-104	346.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions,2X5MB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_4526137_3	395964.KE386496_gene677	7.123e-78	265.0	2E0BD@1|root,32VYM@2|Bacteria,1N2FT@1224|Proteobacteria,2UTUW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
HFD3_k127_4526137_4	768706.Desor_1551	9.255e-68	250.0	28HF7@1|root,2ZAT5@2|Bacteria,1VT0D@1239|Firmicutes,24XG8@186801|Clostridia	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase component B subunits	-	-	-	-	-	-	-	-	-	-	-	-	Gly_reductase
HFD3_k127_4526137_10	246194.CHY_2393	3.638e-20	92.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,42HVI@68295|Thermoanaerobacterales	186801|Clostridia	C	Glycine reductase complex component B subunit gamma	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HFD3_k127_4526137_2	457415.HMPREF1006_00827	2.855e-84	291.0	COG1978@1|root,COG1978@2|Bacteria,3TA3Z@508458|Synergistetes	508458|Synergistetes	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HFD3_k127_4526137_12	928724.SacglDRAFT_00962	0.0001259	47.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4DYSI@85010|Pseudonocardiales	201174|Actinobacteria	EH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_4526137_7	380358.XALC_2529	4.2e-32	132.0	COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales	135614|Xanthomonadales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD3_k127_4526137_9	67267.JNXT01000003_gene3800	3.473e-20	93.0	COG1052@1|root,COG1052@2|Bacteria,2I3KH@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_4550119_3	1205680.CAKO01000006_gene3160	6.818e-13	69.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VEZC@28211|Alphaproteobacteria,2JU3P@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_N
HFD3_k127_4550119_2	926562.Oweho_1731	3.09e-77	274.0	COG0438@1|root,COG0438@2|Bacteria,4NJXT@976|Bacteroidetes,1I2SU@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Sulfotransfer_1
HFD3_k127_4550119_1	111780.Sta7437_0791	1.182e-95	327.0	COG0438@1|root,COG0438@2|Bacteria,1G104@1117|Cyanobacteria,3VJ9J@52604|Pleurocapsales	1117|Cyanobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_4550119_0	935840.JAEQ01000019_gene2102	1.049e-148	497.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,43H6S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03520	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_458271_3	697303.Thewi_1630	4.13e-86	295.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD3_k127_458271_2	1211115.ALIQ01000087_gene4495	2.461e-96	326.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,3NCZ8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD3_k127_458271_4	1380394.JADL01000007_gene4510	1.185e-68	240.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria,2JSKI@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N
HFD3_k127_458271_7	1379270.AUXF01000004_gene3289	7.831e-19	91.0	COG2010@1|root,COG2010@2|Bacteria,1ZUYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_458271_6	1282362.AEAC466_02065	5.47e-36	138.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2KH3Y@204458|Caulobacterales	204458|Caulobacterales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD3_k127_458271_0	290397.Adeh_3594	1.015e-255	797.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD3_k127_458271_5	671143.DAMO_2768	6.182e-37	144.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HFD3_k127_458271_1	1121403.AUCV01000006_gene401	8.003e-118	387.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MN5K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_4604652_3	373994.Riv7116_1332	5.727e-71	252.0	COG0463@1|root,COG0463@2|Bacteria,1GQ4G@1117|Cyanobacteria,1HN6Q@1161|Nostocales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
HFD3_k127_4604652_1	1444712.BN1013_02253	2.468e-155	500.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	vioA	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308,ko:K20429	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
HFD3_k127_4604652_6	686340.Metal_1925	9.315e-11	66.0	28HYD@1|root,2Z83U@2|Bacteria,1R5TY@1224|Proteobacteria,1RQN8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HFD3_k127_4604652_4	1122226.AUHX01000004_gene1803	9.217e-65	229.0	COG0457@1|root,COG0457@2|Bacteria,4NNQK@976|Bacteroidetes,1I2J9@117743|Flavobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4604652_2	1123060.JONP01000004_gene705	5.399e-116	385.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,2JQ9I@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_4604652_0	460265.Mnod_1229	9.169e-172	550.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HFD3_k127_4604652_5	83406.HDN1F_32940	2.034e-34	138.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ACT domain	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
HFD3_k127_4660067_3	1231391.AMZF01000094_gene113	5.131e-67	234.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria	1224|Proteobacteria	E	ethanolamine utilization protein	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
HFD3_k127_4660067_4	1453503.AU05_21100	4.387e-37	148.0	2AHFH@1|root,317ST@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4145
HFD3_k127_4660067_6	234267.Acid_6411	7.799e-21	95.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HFD3_k127_4660067_5	1156919.QWC_31196	2.184e-29	125.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
HFD3_k127_4660067_0	330214.NIDE2086	7.797e-245	796.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD3_k127_4660067_2	330214.NIDE2085	1.978e-171	577.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HFD3_k127_4666637_2	742726.HMPREF9448_01502	2.053e-45	184.0	COG1807@1|root,COG1807@2|Bacteria,4NKI5@976|Bacteroidetes,2FMT9@200643|Bacteroidia,22WVD@171551|Porphyromonadaceae	976|Bacteroidetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HFD3_k127_4666637_0	713586.KB900536_gene377	1.146e-109	364.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria,1X2QZ@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_4666637_1	1380394.JADL01000003_gene4990	2.855e-61	224.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_4666637_3	1415166.NONO_c44050	1.254e-25	113.0	COG2514@1|root,COG2514@2|Bacteria,2GUZK@201174|Actinobacteria,4G92F@85025|Nocardiaceae	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HFD3_k127_4666637_4	1267535.KB906767_gene3245	1.795e-05	48.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HFD3_k127_4673901_5	138119.DSY4783	6.245e-88	306.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
HFD3_k127_4673901_19	1449044.JMLE01000018_gene1661	1.207e-15	88.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4673901_20	1122614.JHZF01000017_gene2810	8.326e-11	66.0	COG3181@1|root,COG3181@2|Bacteria,1PF42@1224|Proteobacteria,2V8PZ@28211|Alphaproteobacteria,2PFVC@252301|Oceanicola	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4673901_21	497964.CfE428DRAFT_6311	1.182e-06	55.0	299BV@1|root,2ZWES@2|Bacteria,46WNG@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4673901_18	1266998.ATUJ01000004_gene1463	8.772e-28	124.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2PVP5@265|Paracoccus	28211|Alphaproteobacteria	S	NMT1-like family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_4673901_22	441769.ABFU01000061_gene449	3.487e-05	47.0	COG1943@1|root,COG1943@2|Bacteria,1V553@1239|Firmicutes,4HV8F@91061|Bacilli,1ZCR8@1386|Bacillus	91061|Bacilli	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HFD3_k127_4673901_0	330214.NIDE1868	0.0	1726.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
HFD3_k127_4673901_12	1041146.ATZB01000004_gene6361	1.405e-43	176.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,4B9Q3@82115|Rhizobiaceae	28211|Alphaproteobacteria	KQ	arsR family	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
HFD3_k127_4673901_14	237368.SCABRO_00474	5.352e-38	149.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	tehB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,TehB
HFD3_k127_4673901_9	316067.Geob_0615	3.157e-56	205.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,43UT3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HFD3_k127_4673901_1	443143.GM18_4206	6.487e-186	596.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,43T5X@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HFD3_k127_4673901_16	56780.SYN_01339	7.439e-35	138.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2MQM6@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HFD3_k127_4673901_8	1232410.KI421412_gene397	1.228e-59	213.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,42SD9@68525|delta/epsilon subdivisions,2WPPN@28221|Deltaproteobacteria,43TRZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Cytidylyltransferase-like	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3200	CTP_transf_like
HFD3_k127_4673901_2	1123371.ATXH01000038_gene1353	1.066e-163	524.0	COG0014@1|root,COG0014@2|Bacteria,2GH1U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD3_k127_4673901_4	1232410.KI421412_gene395	2.458e-111	371.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,43T3Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
HFD3_k127_4673901_3	760568.Desku_0428	4.322e-119	392.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25ZZB@186807|Peptococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HFD3_k127_4673901_15	1121405.dsmv_3222	2.944e-36	138.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HFD3_k127_4673901_17	631454.N177_1836	4.064e-30	122.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria,1JP7F@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
HFD3_k127_4673901_13	485913.Krac_2685	8.028e-40	154.0	COG1846@1|root,COG1846@2|Bacteria,2G8V5@200795|Chloroflexi	200795|Chloroflexi	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HFD3_k127_4673901_6	1173263.Syn7502_03006	4.001e-76	265.0	COG0600@1|root,COG0600@2|Bacteria,1G1ZK@1117|Cyanobacteria,1GZMV@1129|Synechococcus	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_4673901_7	330214.NIDE4332	3.523e-67	234.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD3_k127_4673901_10	1123261.AXDW01000009_gene101	7.293e-52	196.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,1S38U@1236|Gammaproteobacteria,1XC3C@135614|Xanthomonadales	135614|Xanthomonadales	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD3_k127_4673901_11	1232410.KI421421_gene3802	3.716e-45	174.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42QZE@68525|delta/epsilon subdivisions,2WMQH@28221|Deltaproteobacteria,43W06@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD3_k127_4676246_8	1071085.KK033115_gene2427	6.251e-17	89.0	COG2423@1|root,arCOG01035@2157|Archaea,2XT4P@28890|Euryarchaeota,23TF8@183963|Halobacteria	183963|Halobacteria	E	ornithine cyclodeaminase mu-crystallin	ocd2	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_4676246_3	1380394.JADL01000013_gene703	7.019e-59	216.0	COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria,2JVHZ@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_4676246_6	861299.J421_2552	1.65e-31	134.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD3_k127_4676246_2	1379858.N508_00615	5.206e-136	442.0	COG0075@1|root,COG0075@2|Bacteria,2GEIZ@200930|Deferribacteres	200930|Deferribacteres	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD3_k127_4676246_1	56780.SYN_00123	1.245e-178	573.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD3_k127_4676246_0	269799.Gmet_3260	6.6e-183	581.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,43U60@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD3_k127_4676246_4	1231391.AMZF01000046_gene961	2.499e-57	213.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4676246_7	1231391.AMZF01000003_gene3114	4.556e-23	111.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4676246_5	1211115.ALIQ01000008_gene4283	1.56e-41	166.0	COG0329@1|root,COG0329@2|Bacteria,1R73B@1224|Proteobacteria,2U0S8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_4689626_3	247490.KSU1_C1709	1.638e-46	179.0	COG0463@1|root,COG0463@2|Bacteria,2J1MA@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_4689626_2	62928.azo3260	2.347e-68	248.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pssH	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD3_k127_4689626_1	1095769.CAHF01000010_gene1299	1.375e-96	329.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,2VJ9J@28216|Betaproteobacteria,476WG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HFD3_k127_4689626_4	1128421.JAGA01000001_gene2335	4.947e-32	141.0	COG2244@1|root,COG2244@2|Bacteria,2NRKQ@2323|unclassified Bacteria	2|Bacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C,Wzy_C
HFD3_k127_4689626_0	886293.Sinac_5465	2.073e-179	577.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_4691978_8	861299.J421_6009	9.124e-17	82.0	2E328@1|root,32Y2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4691978_5	1254432.SCE1572_15910	2.277e-84	289.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD3_k127_4691978_0	1232410.KI421413_gene952	2.387e-267	847.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,4378Y@68525|delta/epsilon subdivisions,2X2C1@28221|Deltaproteobacteria,43UD2@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD3_k127_4691978_3	56110.Oscil6304_3407	9.926e-175	558.0	COG1252@1|root,COG1252@2|Bacteria,1G20T@1117|Cyanobacteria,1H80B@1150|Oscillatoriales	1117|Cyanobacteria	C	NADH dehydrogenase, FAD-containing subunit	ndbA	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD3_k127_4691978_4	690850.Desaf_0959	2.198e-123	406.0	COG2327@1|root,COG2327@2|Bacteria,1R9R8@1224|Proteobacteria,42U55@68525|delta/epsilon subdivisions,2WQGP@28221|Deltaproteobacteria,2MDZ8@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HFD3_k127_4691978_1	247490.KSU1_D0482	6.074e-225	705.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HFD3_k127_4691978_6	472759.Nhal_0251	1.969e-77	269.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HFD3_k127_4691978_7	237609.PSAKL28_22670	2.991e-39	154.0	2BXI0@1|root,2Z9A2@2|Bacteria,1R9XN@1224|Proteobacteria,1S39A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2459)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
HFD3_k127_4691978_2	267608.RSp0475	1.331e-177	567.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,1K2CQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HFD3_k127_4723848_8	386456.JQKN01000011_gene736	4.525e-10	63.0	arCOG10135@1|root,arCOG10135@2157|Archaea,2Y112@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4723848_6	1116472.MGMO_15c00080	2.047e-40	154.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1SA4A@1236|Gammaproteobacteria,1XFUA@135618|Methylococcales	135618|Methylococcales	L	Protein of unknown function (DUF559)	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF559
HFD3_k127_4723848_2	29540.C481_20726	4.911e-77	270.0	arCOG10131@1|root,arCOG10131@2157|Archaea,2XWNY@28890|Euryarchaeota,23V3W@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4723848_7	1038860.AXAP01000097_gene5007	3.666e-32	138.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,3K1ZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_4723848_5	1173263.Syn7502_03004	5.333e-43	170.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4723848_1	1120983.KB894572_gene3271	3.005e-107	354.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_4723848_0	1217718.ALOU01000009_gene1072	8.042e-120	396.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN32@28216|Betaproteobacteria	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_4723848_4	762376.AXYL_00933	3.893e-60	223.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria,3T54S@506|Alcaligenaceae	28216|Betaproteobacteria	H	CoA-transferase family III	bbsE	-	2.8.3.15	ko:K07543	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HFD3_k127_4723848_3	1435356.Y013_22440	4.051e-75	267.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_4737311_2	1268622.AVS7_03081	5.157e-65	246.0	COG3829@1|root,COG3920@1|root,COG5002@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,COG5002@2|Bacteria,1MVPJ@1224|Proteobacteria,2VN2J@28216|Betaproteobacteria,4AEHS@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9
HFD3_k127_4737311_0	1469607.KK073768_gene1538	1.391e-238	754.0	COG1352@1|root,COG1352@2|Bacteria,1G1W9@1117|Cyanobacteria,1HK56@1161|Nostocales	1117|Cyanobacteria	NT	PFAM CheR methyltransferase, SAM binding domain	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheR,CheR_N,PAS,PAS_4,PAS_9
HFD3_k127_4737311_1	56107.Cylst_1816	6.112e-89	297.0	COG2201@1|root,COG2201@2|Bacteria,1G50Z@1117|Cyanobacteria,1HIJH@1161|Nostocales	1117|Cyanobacteria	NT	PFAM CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
HFD3_k127_4737311_3	404380.Gbem_0899	8.661e-16	91.0	COG2982@1|root,COG2982@2|Bacteria,1QA6E@1224|Proteobacteria,42URI@68525|delta/epsilon subdivisions,2WQ69@28221|Deltaproteobacteria,43U4E@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA,AsmA_2,DUF3971,DUF748
HFD3_k127_4740367_0	1380394.JADL01000022_gene4	1.794e-106	360.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JW26@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD3_k127_4740367_4	1231190.NA8A_08969	1.469e-24	108.0	COG0251@1|root,COG0251@2|Bacteria,1RDJX@1224|Proteobacteria,2U7F4@28211|Alphaproteobacteria,43M0A@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	MA20_04225	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD3_k127_4740367_3	509191.AEDB02000003_gene999	3.857e-91	317.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,3WJ6E@541000|Ruminococcaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_4740367_2	290402.Cbei_3002	3.51e-92	311.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,36W1T@31979|Clostridiaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_4740367_1	1207075.PputUW4_00181	4.794e-100	330.0	COG0500@1|root,COG2226@2|Bacteria,1QU8Z@1224|Proteobacteria,1RXZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HFD3_k127_4740367_6	1144310.PMI07_004507	4.571e-18	96.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4743224_18	525904.Tter_2232	3.96e-51	186.0	COG1319@1|root,COG1319@2|Bacteria,2NQP8@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4743224_2	1295642.H839_05944	1.176e-162	541.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4IHDX@91061|Bacilli,1WH5Q@129337|Geobacillus	91061|Bacilli	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.8	ko:K16877	ko00365,ko01120,map00365,map01120	-	R02987	RC01856	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_4743224_11	1111479.AXAR01000006_gene733	1.095e-64	225.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HINQ@91061|Bacilli	91061|Bacilli	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_4743224_17	795797.C497_17047	3.957e-52	197.0	COG2141@1|root,arCOG02410@2157|Archaea,2XT6F@28890|Euryarchaeota,23TX5@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4743224_4	1089553.Tph_c23930	1.684e-133	439.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,42HS5@68295|Thermoanaerobacterales	186801|Clostridia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_4743224_19	1038858.AXBA01000001_gene3477	1.999e-46	180.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria	1224|Proteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4743224_14	1123288.SOV_4c07790	5.061e-60	216.0	COG0600@1|root,COG0600@2|Bacteria,1TQ26@1239|Firmicutes,4H2KK@909932|Negativicutes	909932|Negativicutes	P	membrane	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_4743224_8	647113.Metok_0637	2.407e-75	262.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,23QHW@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_4743224_15	1382306.JNIM01000001_gene2695	2.399e-58	206.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_4743224_5	1382356.JQMP01000001_gene1179	6.187e-83	285.0	COG1319@1|root,COG1319@2|Bacteria,2G7KW@200795|Chloroflexi,27Z00@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4743224_0	316058.RPB_3096	6.184e-245	781.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_4743224_10	264732.Moth_2003	1.825e-65	241.0	COG0740@1|root,COG2068@1|root,COG0740@2|Bacteria,COG2068@2|Bacteria,1TTYG@1239|Firmicutes,25KEI@186801|Clostridia,42IJF@68295|Thermoanaerobacterales	186801|Clostridia	OU	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD3_k127_4743224_6	926550.CLDAP_11640	1.363e-80	277.0	COG3608@1|root,COG3608@2|Bacteria,2G71G@200795|Chloroflexi	200795|Chloroflexi	S	succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	-
HFD3_k127_4743224_16	1125863.JAFN01000001_gene1570	3.038e-55	198.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_4743224_13	370438.PTH_1540	2.464e-61	222.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,264MQ@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4743224_3	266834.SM_b20132	6.486e-155	516.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,4BME9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03520	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
HFD3_k127_4743224_23	240292.Ava_1239	5.12e-16	79.0	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HQBR@1161|Nostocales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HFD3_k127_4743224_22	1122915.AUGY01000020_gene6479	2.787e-22	108.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4743224_24	1211115.ALIQ01000071_gene3809	1.414e-06	60.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2TTB8@28211|Alphaproteobacteria,3NCW4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	NMT1-like family	MA20_34190	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4743224_1	523845.AQXV01000052_gene565	5.249e-185	602.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
HFD3_k127_4743224_7	667632.KB890195_gene3478	6.173e-76	264.0	COG2513@1|root,COG2513@2|Bacteria,1PISN@1224|Proteobacteria,2W9Z1@28216|Betaproteobacteria,1KDWF@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD3_k127_4743224_9	644966.Tmar_1492	9.691e-70	246.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4743224_12	1463857.JOFZ01000001_gene5444	4.52e-62	218.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_4744188_4	179408.Osc7112_5179	1.561e-68	243.0	COG1020@1|root,COG1020@2|Bacteria,1G4I1@1117|Cyanobacteria,1HAAY@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM AMP-dependent synthetase ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
HFD3_k127_4744188_1	56107.Cylst_1620	6.489e-158	520.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_4744188_6	292459.STH1969	2.448e-05	56.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4744188_2	56107.Cylst_1620	2.563e-142	473.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_4744188_0	56107.Cylst_1620	2.382e-172	562.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_4744188_5	378806.STAUR_1870	2.09e-34	132.0	COG3251@1|root,COG3251@2|Bacteria,1PIM0@1224|Proteobacteria,43DZX@68525|delta/epsilon subdivisions,2WZAZ@28221|Deltaproteobacteria,2Z1R2@29|Myxococcales	28221|Deltaproteobacteria	S	MbtH-like protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH
HFD3_k127_4744188_3	221288.JH992901_gene3911	7.758e-123	399.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JJA2@1189|Stigonemataceae	1117|Cyanobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase
HFD3_k127_4748013_3	443152.MDG893_15060	1.717e-33	139.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4748013_10	1122603.ATVI01000005_gene3580	4.089e-05	48.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1X4K6@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia	gatAX	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase,Lipocalin_5
HFD3_k127_4748013_2	1038860.AXAP01000043_gene7543	9.87e-35	144.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2U3YG@28211|Alphaproteobacteria,3JX6Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_4748013_6	1463857.JOFZ01000007_gene160	4.571e-18	96.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_4748013_11	1297569.MESS2_1190030	0.0005692	43.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,43MZD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Metallopeptidase family M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_4748013_9	1408444.JHYC01000003_gene646	2.94e-07	55.0	2ENCP@1|root,33G06@2|Bacteria,1P756@1224|Proteobacteria,1SU1K@1236|Gammaproteobacteria,1JF0F@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4748013_7	296591.Bpro_3359	2.527e-14	78.0	COG0527@1|root,COG0527@2|Bacteria,1REUY@1224|Proteobacteria,2VS69@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT,ACT_6
HFD3_k127_4748013_5	335543.Sfum_2110	5.956e-20	97.0	COG2329@1|root,COG2329@2|Bacteria,1Q37Z@1224|Proteobacteria,42WX0@68525|delta/epsilon subdivisions,2WTHF@28221|Deltaproteobacteria,2MSFV@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD3_k127_4748013_0	270374.MELB17_00270	6.015e-53	198.0	COG0535@1|root,COG0535@2|Bacteria,1RBC4@1224|Proteobacteria,1SKEW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HFD3_k127_4748013_8	1198232.CYCME_1426	4.858e-09	67.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pssH	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HFD3_k127_4748013_4	483215.BACFIN_08099	4.451e-30	132.0	COG0438@1|root,COG1216@1|root,COG3754@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG3754@2|Bacteria,4PMPA@976|Bacteroidetes,2G0JS@200643|Bacteroidia,4AV9J@815|Bacteroidaceae	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_4748013_1	436308.Nmar_1658	1.422e-46	176.0	COG1651@1|root,arCOG02868@2157|Archaea	2157|Archaea	O	COG1651 Protein-disulfide isomerase	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
HFD3_k127_4757127_1	767817.Desgi_2403	1.016e-108	371.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,261CY@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K00666,ko:K01897,ko:K12507	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_4757127_0	909663.KI867150_gene31	7.671e-202	641.0	COG0043@1|root,COG0043@2|Bacteria,1Q5FS@1224|Proteobacteria	1224|Proteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_4757127_2	4565.Traes_2BL_2D067BFBA.1	3.309e-45	179.0	COG0693@1|root,KOG2764@2759|Eukaryota,37P4J@33090|Viridiplantae,3GFQW@35493|Streptophyta,3KRMR@4447|Liliopsida,3I3E6@38820|Poales	35493|Streptophyta	V	DJ-1/PfpI family	-	-	4.2.1.130	ko:K18881	ko00620,ko01120,map00620,map01120	-	R09796	RC02658	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD3_k127_4762548_6	56780.SYN_00852	7.602e-126	417.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2MQ4F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HFD3_k127_4762548_7	472759.Nhal_2257	2.427e-113	373.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WWSW@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_4762548_3	318167.Sfri_1812	4.107e-161	516.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
HFD3_k127_4762548_4	335543.Sfum_1085	1.902e-155	505.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MQAX@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD3_k127_4762548_11	909663.KI867150_gene2447	1.707e-51	188.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria,43022@68525|delta/epsilon subdivisions,2WV7R@28221|Deltaproteobacteria,2MRWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
HFD3_k127_4762548_10	658187.LDG_7548	1.757e-63	223.0	COG0778@1|root,COG0778@2|Bacteria,1PGJY@1224|Proteobacteria,1S99H@1236|Gammaproteobacteria,1JE2K@118969|Legionellales	118969|Legionellales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD3_k127_4762548_13	1448860.BBJO01000014_gene1392	1.883e-39	152.0	COG1926@1|root,arCOG06847@2157|Archaea,2XWRW@28890|Euryarchaeota,23V9R@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD3_k127_4762548_17	306281.AJLK01000111_gene5256	1.036e-05	48.0	COG0568@1|root,COG0568@2|Bacteria,1G1HF@1117|Cyanobacteria,1JI7I@1189|Stigonemataceae	1117|Cyanobacteria	K	Sigma-70, region 4	-	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD3_k127_4762548_5	1266925.JHVX01000003_gene514	1.073e-147	476.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2VIGZ@28216|Betaproteobacteria,372V2@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	Mur_ligase_M,PGA_cap
HFD3_k127_4762548_9	378806.STAUR_5197	5.624e-97	326.0	COG0462@1|root,COG0462@2|Bacteria,1RCRN@1224|Proteobacteria,42QPH@68525|delta/epsilon subdivisions,2WMQV@28221|Deltaproteobacteria,2YU6H@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HFD3_k127_4762548_1	288000.BBta_7794	1.1e-285	900.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3JTMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD3_k127_4762548_15	1305735.JAFT01000005_gene2679	1.988e-11	70.0	2AIN2@1|root,3194E@2|Bacteria,1Q1SK@1224|Proteobacteria,2V9EV@28211|Alphaproteobacteria,2PEW1@252301|Oceanicola	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4762548_8	472759.Nhal_2956	1.751e-110	361.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD3_k127_4762548_2	472759.Nhal_1958	5.064e-178	575.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8
HFD3_k127_4762548_12	670487.Ocepr_2130	1.766e-48	177.0	COG5502@1|root,COG5502@2|Bacteria,1WJW9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
HFD3_k127_4762548_14	404589.Anae109_4120	9.298e-27	113.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2Z0MS@29|Myxococcales	28221|Deltaproteobacteria	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD3_k127_4762548_16	640512.BC1003_1741	3.838e-06	54.0	2FBMQ@1|root,343ST@2|Bacteria,1P1SE@1224|Proteobacteria,2W4K8@28216|Betaproteobacteria,1K8BE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1488
HFD3_k127_4762548_0	330214.NIDE3826	0.0	1555.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3J0XX@40117|Nitrospirae	40117|Nitrospirae	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HFD3_k127_4764607_10	1047013.AQSP01000138_gene1058	1.451e-13	72.0	COG0182@1|root,COG0182@2|Bacteria,2NNM7@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
HFD3_k127_4764607_9	234267.Acid_6712	2.22e-33	133.0	COG0736@1|root,COG0736@2|Bacteria,3Y590@57723|Acidobacteria	57723|Acidobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD3_k127_4764607_5	1122222.AXWR01000001_gene1920	1.218e-125	413.0	COG0683@1|root,COG0683@2|Bacteria,1WI02@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HFD3_k127_4764607_3	1499967.BAYZ01000016_gene6567	5.69e-140	456.0	COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD3_k127_4764607_11	743720.Psefu_0855	8.32e-10	68.0	COG1357@1|root,COG1357@2|Bacteria,1MZAT@1224|Proteobacteria,1S9V6@1236|Gammaproteobacteria,1YVK0@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HFD3_k127_4764607_6	333138.LQ50_20165	4.71e-96	329.0	2A6Y1@1|root,30VSZ@2|Bacteria,1UBKQ@1239|Firmicutes,4IN0U@91061|Bacilli,1ZMG5@1386|Bacillus	91061|Bacilli	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_4764607_1	671143.DAMO_2832	5.257e-248	774.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	hycE	-	-	ko:K14089	-	-	-	-	ko00000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HFD3_k127_4764607_2	671143.DAMO_2831	4.971e-208	657.0	COG0651@1|root,COG0651@2|Bacteria,2NS4P@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Proton_antipo_M,Proton_antipo_N
HFD3_k127_4764607_8	671143.DAMO_2830	2.186e-79	280.0	COG4237@1|root,COG4237@2|Bacteria	2|Bacteria	C	Hydrogenase 4 membrane	hyfE	GO:0008150,GO:0040007	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD3_k127_4764607_4	671143.DAMO_2829	1.069e-135	442.0	COG0650@1|root,COG0650@2|Bacteria,2NRV1@2323|unclassified Bacteria	2|Bacteria	C	NADH dehydrogenase	hycD	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD3_k127_4764607_0	671143.DAMO_2828	1.106e-287	902.0	COG0651@1|root,COG0651@2|Bacteria,2NR9Z@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K12137,ko:K15828	-	-	-	-	ko00000,ko01000	-	-	iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEKO11_1354.EKO11_1252,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330	Proton_antipo_M,Proton_antipo_N
HFD3_k127_4764607_7	671143.DAMO_2827	1.578e-82	277.0	COG3260@1|root,COG3260@2|Bacteria,2NRM4@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HFD3_k127_476671_4	247490.KSU1_B0323	1.769e-96	323.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HFD3_k127_476671_1	1173029.JH980292_gene2207	0.0	1086.0	COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1H9QJ@1150|Oscillatoriales	1117|Cyanobacteria	G	Maltooligosyl trehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HFD3_k127_476671_2	1173027.Mic7113_3737	2.506e-274	860.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1G2ZI@1117|Cyanobacteria,1H9FE@1150|Oscillatoriales	1117|Cyanobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
HFD3_k127_476671_0	477974.Daud_0851	0.0	1427.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,264Z9@186807|Peptococcaceae	186801|Clostridia	G	Alpha-amylase domain	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HFD3_k127_476671_3	909663.KI867150_gene875	2.711e-187	599.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR1E@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714,ko:K07715	ko02020,ko02024,map02020,map02024	M00500,M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_476671_5	215803.DB30_2740	5.677e-66	231.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2YVDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD3_k127_476671_8	247490.KSU1_C0925	9.48e-19	88.0	2DRFV@1|root,33BJD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3185
HFD3_k127_476671_10	240015.ACP_1069	9.884e-06	51.0	COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria,2JK01@204432|Acidobacteriia	204432|Acidobacteriia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
HFD3_k127_476671_9	1500894.JQNN01000001_gene3775	7.383e-08	58.0	COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,2VUHT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART Transport-associated and nodulation region	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HFD3_k127_476671_6	671143.DAMO_1116	1.608e-58	217.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_476671_7	1298867.AUES01000019_gene3502	3.608e-29	121.0	COG0517@1|root,COG0517@2|Bacteria,1NMH1@1224|Proteobacteria,2U9D8@28211|Alphaproteobacteria,3JZSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD3_k127_4769856_0	1201288.M900_A0332	9.24e-128	414.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,42M34@68525|delta/epsilon subdivisions,2MSKZ@213481|Bdellovibrionales,2WKJ6@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HFD3_k127_4769856_3	384676.PSEEN2893	8.634e-07	59.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,1SCVY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4769856_2	864069.MicloDRAFT_00046360	4.006e-13	80.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,1JTV0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4769856_1	316067.Geob_1232	2.334e-115	378.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,43U9W@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD3_k127_4771142_1	1038862.KB893877_gene5928	5.88e-32	124.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,3JUYT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
HFD3_k127_4771142_2	504832.OCAR_5272	7.794e-12	71.0	COG4321@1|root,COG4321@2|Bacteria,1N7Z2@1224|Proteobacteria,2UF7W@28211|Alphaproteobacteria,3K0CA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Ribbon-helix-helix domain	MA20_02235	-	-	-	-	-	-	-	-	-	-	-	RHH_4
HFD3_k127_4771142_0	224911.27350726	5.718e-53	192.0	COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,2U552@28211|Alphaproteobacteria,3JXTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD3_k127_4780768_6	215803.DB30_5420	1.09e-77	274.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,42QBK@68525|delta/epsilon subdivisions,2WITZ@28221|Deltaproteobacteria,2YW16@29|Myxococcales	28221|Deltaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD3_k127_4780768_3	269799.Gmet_2296	7.9e-139	454.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2WJEE@28221|Deltaproteobacteria,43T2G@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD3_k127_4780768_9	671143.DAMO_1375	3.543e-45	169.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
HFD3_k127_4780768_16	1313301.AUGC01000003_gene1936	0.0005731	50.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes	976|Bacteroidetes	G	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
HFD3_k127_4780768_7	671143.DAMO_2862	2.864e-67	233.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	def2	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD3_k127_4780768_1	1382356.JQMP01000001_gene1157	4.741e-173	552.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HFD3_k127_4780768_13	1307759.JOMJ01000003_gene549	1.865e-17	91.0	2E6CS@1|root,3310E@2|Bacteria,1N2FR@1224|Proteobacteria,42UY2@68525|delta/epsilon subdivisions,2WPMU@28221|Deltaproteobacteria,2M8VJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4780768_0	1121405.dsmv_0285	2.813e-228	728.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD3_k127_4780768_2	338963.Pcar_1041	7.45e-145	470.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,43SAP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HFD3_k127_4780768_12	1304284.L21TH_2567	2.808e-30	129.0	28PHB@1|root,2ZC7V@2|Bacteria,1V1MY@1239|Firmicutes,24H5K@186801|Clostridia,36IHD@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4780768_11	706587.Desti_2460	1.75e-33	138.0	299T8@1|root,2ZWVF@2|Bacteria,1N5QA@1224|Proteobacteria,42ZI5@68525|delta/epsilon subdivisions,2WV28@28221|Deltaproteobacteria,2MRN5@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4780768_10	710685.MycrhN_3187	3.685e-45	178.0	COG2030@1|root,COG2030@2|Bacteria,2I9BC@201174|Actinobacteria,236FG@1762|Mycobacteriaceae	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
HFD3_k127_4780768_8	926550.CLDAP_16300	6.91e-63	219.0	COG2030@1|root,COG2030@2|Bacteria,2G6YG@200795|Chloroflexi	200795|Chloroflexi	I	PFAM MaoC domain protein dehydratase	-	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HFD3_k127_4780768_4	266117.Rxyl_0941	1.033e-108	361.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,4CSI0@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4780768_15	502025.Hoch_5959	6.18e-07	51.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
HFD3_k127_4780768_5	1382306.JNIM01000001_gene1213	4.064e-91	308.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_4781888_2	1254432.SCE1572_26680	6.797e-42	166.0	COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD3_k127_4781888_1	196162.Noca_0849	5.044e-53	200.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4DRW9@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4781888_0	1123023.JIAI01000001_gene6559	1.668e-71	247.0	COG0252@1|root,COG0252@2|Bacteria,2HUB2@201174|Actinobacteria,4E3K5@85010|Pseudonocardiales	201174|Actinobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HFD3_k127_4784449_0	1232410.KI421421_gene3555	2.321e-38	148.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,43SJQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L9, N-terminal domain	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD3_k127_4784449_1	56780.SYN_00642	1.034e-25	118.0	COG4241@1|root,COG4241@2|Bacteria,1N4XJ@1224|Proteobacteria,42QCS@68525|delta/epsilon subdivisions,2WKDT@28221|Deltaproteobacteria,2MS2Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HFD3_k127_4784449_2	1304885.AUEY01000010_gene1648	3.755e-24	104.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MKM0@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD3_k127_4784449_3	1121439.dsat_1334	1.191e-21	98.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,42TJR@68525|delta/epsilon subdivisions,2WRDG@28221|Deltaproteobacteria,2MCE6@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD3_k127_4784449_4	867903.ThesuDRAFT_00412	2.306e-19	89.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WCIX@538999|Clostridiales incertae sedis	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HFD3_k127_4819359_5	56110.Oscil6304_5208	2.401e-63	231.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	1117|Cyanobacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_4819359_3	562970.Btus_2324	1.876e-89	318.0	COG3435@1|root,COG3435@2|Bacteria,1UYG0@1239|Firmicutes,4HCWV@91061|Bacilli,278ZZ@186823|Alicyclobacillaceae	91061|Bacilli	Q	Cupin domain	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HFD3_k127_4819359_7	1131814.JAFO01000001_gene1125	4.361e-21	108.0	COG1413@1|root,COG1413@2|Bacteria,1R4SF@1224|Proteobacteria,2TU29@28211|Alphaproteobacteria,3F1EP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	PBS lyase HEAT-like repeat	MA20_14850	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HFD3_k127_4819359_4	56780.SYN_01481	3.789e-85	305.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HFD3_k127_4819359_0	1267534.KB906760_gene1562	2.575e-164	554.0	COG3604@1|root,COG3829@1|root,COG3604@2|Bacteria,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria	57723|Acidobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Sigma54_activat
HFD3_k127_4819359_6	314230.DSM3645_06149	2.506e-28	125.0	COG1595@1|root,COG1595@2|Bacteria,2J0GI@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_4819359_8	1278073.MYSTI_07070	4.995e-06	55.0	2DTSQ@1|root,33MH7@2|Bacteria,1NGXY@1224|Proteobacteria,42XSM@68525|delta/epsilon subdivisions,2WSY2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_4819359_9	518766.Rmar_2225	5.114e-05	50.0	COG5660@1|root,COG5660@2|Bacteria,4PF9I@976|Bacteroidetes,1FKBP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_4819359_1	215803.DB30_0441	1.779e-127	418.0	COG1063@1|root,COG1063@2|Bacteria,1NXSN@1224|Proteobacteria,438FZ@68525|delta/epsilon subdivisions,2X3QX@28221|Deltaproteobacteria,2YWVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glucose dehydrogenase C-terminus	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HFD3_k127_4819359_2	63737.Npun_F2213	2.342e-103	342.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria,1HRP9@1161|Nostocales	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD3_k127_4821163_0	243231.GSU2629	5.871e-120	397.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,43UF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_4821163_2	868131.MSWAN_0290	1.17e-15	89.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,23NUG@183925|Methanobacteria	183925|Methanobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
HFD3_k127_4821163_1	880072.Desac_0245	7.006e-48	176.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2X5F5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HFD3_k127_4843958_4	1470591.BW41_00551	1.759e-23	107.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2K1MY@204457|Sphingomonadales	204457|Sphingomonadales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD3_k127_4843958_0	443152.MDG893_15307	4.766e-104	351.0	2C1EV@1|root,33RW1@2|Bacteria,1R3AA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4843958_2	935840.JAEQ01000019_gene2104	4.497e-60	218.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_4843958_3	706587.Desti_1107	7.536e-52	191.0	COG2080@1|root,COG2080@2|Bacteria,1PGQD@1224|Proteobacteria,434AK@68525|delta/epsilon subdivisions,2X9WM@28221|Deltaproteobacteria,2MRQZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_4843958_1	1449126.JQKL01000016_gene2867	7.299e-95	329.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,26828@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_4853108_2	1128421.JAGA01000001_gene2427	1.466e-78	267.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2NPBQ@2323|unclassified Bacteria	2|Bacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	hemD	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01719,ko:K01749,ko:K02303,ko:K13542,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755,iJN678.hemD	HEM4,TP_methylase
HFD3_k127_4853108_3	1009370.ALO_10609	3.765e-44	168.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,4H4P0@909932|Negativicutes	909932|Negativicutes	H	Siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
HFD3_k127_4853108_1	1459636.NTE_02662	3.774e-93	311.0	COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HFD3_k127_4853108_4	1128427.KB904821_gene3905	6.975e-21	100.0	2DUA0@1|root,33PJB@2|Bacteria,1GD0Q@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4853108_0	502025.Hoch_5119	9.95e-154	497.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q77@68525|delta/epsilon subdivisions,2WK3N@28221|Deltaproteobacteria,2YU8G@29|Myxococcales	28221|Deltaproteobacteria	C	Sulfite reductase	-	-	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HFD3_k127_4853656_1	926550.CLDAP_32740	1.208e-125	411.0	COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	bisC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_4853656_2	523841.HFX_2236	2.545e-05	50.0	COG1977@1|root,arCOG00536@2157|Archaea,2XYQA@28890|Euryarchaeota,23WPF@183963|Halobacteria	183963|Halobacteria	H	COG1977 Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD3_k127_4853656_0	76114.ebA5622	7.378e-193	631.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_4863645_7	196162.Noca_0856	4.545e-24	109.0	COG2141@1|root,COG2141@2|Bacteria,2IFUW@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_4863645_3	1144310.PMI07_005447	8.177e-56	209.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_4863645_2	748247.AZKH_2012	4.89e-73	274.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,2KVI1@206389|Rhodocyclales	28216|Betaproteobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HFD3_k127_4863645_6	391623.TERMP_01161	2.413e-32	138.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	183968|Thermococci	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_4863645_4	1173263.Syn7502_03004	8.286e-50	191.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_4863645_5	1231391.AMZF01000068_gene2180	7.431e-39	160.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_4863645_0	1042326.AZNV01000012_gene1943	8.834e-125	420.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,4BAT1@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_4863645_1	1205680.CAKO01000037_gene1313	2.013e-122	413.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HFD3_k127_4863645_8	1449063.JMLS01000027_gene61	4.369e-07	60.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_486521_1	479434.Sthe_2712	3.31e-134	437.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	4.1.1.45	ko:K03392,ko:K07045	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_486521_0	589924.Ferp_2318	2.85e-247	779.0	COG1249@1|root,COG1902@1|root,arCOG00615@2157|Archaea,arCOG01068@2157|Archaea,2XT27@28890|Euryarchaeota,246QS@183980|Archaeoglobi	183980|Archaeoglobi	C	NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HFD3_k127_4916706_0	1038860.AXAP01000015_gene2094	0.0	1433.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	aldehyde-lyase activity	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HFD3_k127_4916706_15	857087.Metme_1870	0.0004566	43.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,1XDYE@135618|Methylococcales	135618|Methylococcales	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD3_k127_4916706_6	396588.Tgr7_2598	6.843e-90	309.0	COG0265@1|root,COG0265@2|Bacteria,1R6MU@1224|Proteobacteria,1S181@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Trypsin-like serine protease	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_4916706_13	1123393.KB891327_gene349	6.911e-12	67.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KSSQ@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Cation transporting ATPase, C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,E1-E2_ATPase,Hydrolase
HFD3_k127_4916706_12	292415.Tbd_2161	4.606e-12	71.0	28KYG@1|root,2ZAE1@2|Bacteria,1R85N@1224|Proteobacteria,2VKUB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4916706_8	290397.Adeh_0445	3.814e-46	171.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
HFD3_k127_4916706_7	909663.KI867150_gene69	1.444e-75	258.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4916706_3	671143.DAMO_0975	1.321e-251	790.0	COG0465@1|root,COG0465@2|Bacteria,2NP22@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD3_k127_4916706_9	671143.DAMO_0988	1.647e-27	122.0	COG1499@1|root,COG1499@2|Bacteria,2NS26@2323|unclassified Bacteria	2|Bacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	NMD3
HFD3_k127_4916706_14	1121920.AUAU01000004_gene850	3.988e-07	56.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HFD3_k127_4916706_10	671143.DAMO_1529	1.788e-20	96.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_4916706_2	671143.DAMO_1138	0.0	1172.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	fdxB	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_4916706_4	1121918.ARWE01000001_gene2709	6.509e-103	341.0	COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,42Q34@68525|delta/epsilon subdivisions,2WN9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM formate nitrite transporter	fdhC	-	-	ko:K06212,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2	-	-	Form_Nir_trans,Response_reg
HFD3_k127_4916706_11	760568.Desku_1239	2.764e-20	97.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,261WS@186807|Peptococcaceae	186801|Clostridia	S	PFAM CBS domain	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HFD3_k127_4916706_1	1121405.dsmv_1861	0.0	1347.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,PTS_EIIA_2
HFD3_k127_4916706_5	118166.JH976537_gene4640	7.231e-97	323.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1G40A@1117|Cyanobacteria,1HI0P@1150|Oscillatoriales	1117|Cyanobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HFD3_k127_4924450_2	658187.LDG_5975	9.084e-67	235.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1JFVA@118969|Legionellales	118969|Legionellales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HFD3_k127_4924450_4	215803.DB30_0177	1.732e-38	154.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42U9W@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	ABC 3 transport family	-	-	-	ko:K09819,ko:K11606,ko:K11708,ko:K11709	ko02010,map02010	M00243,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC-3,Fe_dep_repr_C
HFD3_k127_4924450_3	1038859.AXAU01000002_gene648	1.539e-59	212.0	COG1230@1|root,COG1230@2|Bacteria	2|Bacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
HFD3_k127_4924450_0	1191523.MROS_1386	8.014e-87	294.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.1.1.199	ko:K03438,ko:K13292	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	LGT
HFD3_k127_4924450_1	547163.BN979_03362	2.042e-82	282.0	COG0402@1|root,COG0402@2|Bacteria,2IBR8@201174|Actinobacteria,2372F@1762|Mycobacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.18	ko:K15358	ko00760,ko01120,map00760,map01120	-	R07984	RC01933	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD3_k127_4929823_0	290397.Adeh_1221	2.302e-100	355.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,42ZBA@68525|delta/epsilon subdivisions,2WUF4@28221|Deltaproteobacteria,2YUZP@29|Myxococcales	28221|Deltaproteobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HFD3_k127_4929823_2	247490.KSU1_C0323	5.168e-66	235.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	A2M_comp,DUF4159,Prenyltrans
HFD3_k127_4929823_1	575540.Isop_3542	4.837e-76	280.0	COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,2J513@203682|Planctomycetes	203682|Planctomycetes	G	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HFD3_k127_4929823_3	247490.KSU1_C0185	3.834e-53	194.0	COG1721@1|root,COG1721@2|Bacteria,2IY2F@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD3_k127_4946424_7	247490.KSU1_C0672	8.512e-37	139.0	COG4096@1|root,COG4096@2|Bacteria,2IXTV@203682|Planctomycetes	203682|Planctomycetes	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
HFD3_k127_4946424_4	572547.Amico_1534	2.801e-114	378.0	COG2239@1|root,COG2239@2|Bacteria	2|Bacteria	P	Acts as a magnesium transporter	ppaC	-	3.6.1.1	ko:K04767,ko:K06213,ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.26.1	-	-	CBS,DHH,DHHA2,DRTGG,MgtE,MgtE_N,PRC
HFD3_k127_4946424_11	313628.LNTAR_04106	1.824e-10	64.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_4946424_6	1382356.JQMP01000003_gene1440	3.178e-38	154.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_4946424_8	663610.JQKO01000007_gene2310	8.799e-21	93.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2UFUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_4946424_1	909663.KI867149_gene3370	2.174e-169	557.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD3_k127_4946424_5	909663.KI867149_gene3371	3.506e-103	345.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,42P6V@68525|delta/epsilon subdivisions,2WM6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
HFD3_k127_4946424_9	1366050.N234_06360	1.307e-18	90.0	2AGC9@1|root,33W35@2|Bacteria,1NVNS@1224|Proteobacteria,2W31P@28216|Betaproteobacteria,1KDUT@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4946424_2	1454004.AW11_02632	9.166e-120	395.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VMKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD3_k127_4946424_3	338966.Ppro_0408	1.458e-116	389.0	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_4946424_10	585531.HMPREF0063_11632	5.406e-11	69.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4DMXW@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, cAMP Regulatory protein	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_4946424_0	1267533.KB906734_gene3970	3.099e-189	602.0	COG0364@1|root,COG0364@2|Bacteria,3Y627@57723|Acidobacteria,2JKTN@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD3_k127_4946424_12	863365.XHC_2218	3.189e-08	58.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X4H3@135614|Xanthomonadales	135614|Xanthomonadales	M	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,MscS_TM,MscS_porin
HFD3_k127_4971604_14	1283283.ATXA01000021_gene2854	1.186e-06	55.0	COG0235@1|root,COG0235@2|Bacteria,2HGGU@201174|Actinobacteria,4EWNJ@85013|Frankiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_4971604_5	365046.Rta_20260	1.612e-70	246.0	COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2VMGM@28216|Betaproteobacteria,4ABY0@80864|Comamonadaceae	28216|Betaproteobacteria	ET	SMART Extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HFD3_k127_4971604_6	436229.JOEH01000008_gene4304	8.521e-52	198.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,2NEV5@228398|Streptacidiphilus	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_4971604_8	1286093.C266_16285	3.785e-44	169.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VN9Q@28216|Betaproteobacteria,1K24N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_4971604_4	1382304.JNIL01000001_gene3160	7.989e-79	286.0	COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,4HDXT@91061|Bacilli	91061|Bacilli	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD3_k127_4971604_3	1184607.AUCHE_24_00330	9.069e-93	321.0	COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria	201174|Actinobacteria	E	Tryptophanase	tpl	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD3_k127_4971604_10	1521187.JPIM01000015_gene3747	7.849e-30	124.0	COG1051@1|root,COG1051@2|Bacteria,2G74M@200795|Chloroflexi,375UB@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD3_k127_4971604_11	1267535.KB906767_gene4225	1.489e-29	125.0	COG1324@1|root,COG1324@2|Bacteria,3Y5P7@57723|Acidobacteria	57723|Acidobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HFD3_k127_4971604_7	671143.DAMO_1399	5.029e-47	178.0	COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria	2|Bacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00788,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD3_k127_4971604_0	316067.Geob_1720	2.556e-159	516.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43U5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	gnfM	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_4971604_2	316067.Geob_1719	2.255e-94	322.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,43T97@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Nitrogen fixation master sensor histidine kinase, PAS domain-containing	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HFD3_k127_4971604_9	667014.Thein_0214	7.828e-34	135.0	COG0779@1|root,COG0779@2|Bacteria,2GH5M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD3_k127_4971604_1	589865.DaAHT2_1881	1.693e-140	461.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HFD3_k127_4971604_13	568816.Acin_1590	2.295e-10	64.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,4H5KD@909932|Negativicutes	909932|Negativicutes	K	Protein of unknown function (DUF448)	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HFD3_k127_4971604_12	243231.GSU1588	1.319e-22	110.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43UH5@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HFD3_k127_5019573_12	1121468.AUBR01000001_gene578	3.872e-05	46.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD3_k127_5019573_0	398767.Glov_2760	7.579e-197	628.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,43RZH@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD3_k127_5019573_14	1001530.BACE01000003_gene1453	0.0004035	45.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XT9Q@135623|Vibrionales	135623|Vibrionales	F	Belongs to the GARS family	purD	GO:0003674,GO:0003824,GO:0004637,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD3_k127_5019573_11	1123248.KB893337_gene2566	2.057e-28	120.0	COG5470@1|root,COG5470@2|Bacteria,4NUEC@976|Bacteroidetes,1IZ1F@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HFD3_k127_5019573_13	1205680.CAKO01000006_gene3160	0.0001846	44.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VEZC@28211|Alphaproteobacteria,2JU3P@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_N
HFD3_k127_5019573_2	1121468.AUBR01000017_gene2358	2.95e-159	514.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD3_k127_5019573_6	338963.Pcar_2230	8.536e-54	194.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WPG2@28221|Deltaproteobacteria,43SG8@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	AIR carboxylase	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HFD3_k127_5019573_8	1123371.ATXH01000005_gene2137	1.859e-43	169.0	COG0009@1|root,COG0009@2|Bacteria,2GGWC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HFD3_k127_5019573_9	205922.Pfl01_3712	2.859e-35	141.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,1T07G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_5019573_4	604354.TSIB_0634	7.296e-79	275.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	GO:0000166,GO:0000286,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006522,GO:0006807,GO:0008150,GO:0008152,GO:0009078,GO:0009987,GO:0016491,GO:0016638,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046983,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_5019573_1	1121448.DGI_0294	1.058e-159	522.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2MFEP@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HFD3_k127_5019573_3	1499967.BAYZ01000028_gene1316	1.112e-88	307.0	COG1058@1|root,COG1058@2|Bacteria,2NP0G@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HFD3_k127_5019573_10	1207063.P24_00900	5.537e-29	119.0	COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,2TUI5@28211|Alphaproteobacteria,2JSKQ@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_5019573_5	1205680.CAKO01000006_gene3262	2.333e-67	244.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JQI2@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5019573_7	596154.Alide2_4049	2.787e-53	192.0	COG0318@1|root,COG0318@2|Bacteria,1R6HT@1224|Proteobacteria,2VQR4@28216|Betaproteobacteria,4AH3I@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5026355_0	1449044.JMLE01000029_gene106	3.059e-158	503.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,1WAY5@1268|Micrococcaceae	201174|Actinobacteria	C	Transketolase, C-terminal domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD3_k127_5026355_1	177439.DPPB40	3.61e-130	426.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42PEC@68525|delta/epsilon subdivisions,2X5JG@28221|Deltaproteobacteria,2MMST@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD3_k127_5026355_3	1532558.JL39_10470	3.218e-18	87.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2UFUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_5059495_14	1027273.GZ77_08535	1.099e-22	101.0	COG3012@1|root,COG3012@2|Bacteria,1N1DD@1224|Proteobacteria,1S8TK@1236|Gammaproteobacteria,1XM2G@135619|Oceanospirillales	135619|Oceanospirillales	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HFD3_k127_5059495_5	264462.Bd1389	4.421e-69	241.0	COG3148@1|root,COG3148@2|Bacteria,1QJR0@1224|Proteobacteria,42UN7@68525|delta/epsilon subdivisions,2MUDY@213481|Bdellovibrionales,2WQDN@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	DTW	-	-	-	-	-	-	-	-	-	-	-	-	DTW
HFD3_k127_5059495_1	330214.NIDE3623	7.233e-131	423.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	ytbE	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,DUF4157
HFD3_k127_5059495_12	570268.ANBB01000017_gene3847	1.268e-42	175.0	COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HFD3_k127_5059495_6	471223.GWCH70_0606	7.19e-57	205.0	COG0819@1|root,COG0819@2|Bacteria,1TPK0@1239|Firmicutes,4HCPF@91061|Bacilli,1WF6I@129337|Geobacillus	91061|Bacilli	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	tenA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
HFD3_k127_5059495_0	742821.HMPREF9464_00834	5.506e-188	603.0	COG1053@1|root,COG1053@2|Bacteria,1R0GR@1224|Proteobacteria,2WHU3@28216|Betaproteobacteria,4PRR9@995019|Sutterellaceae	28216|Betaproteobacteria	C	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_5059495_3	1122915.AUGY01000020_gene6474	1.43e-107	353.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	-	-	4.1.1.69,4.1.2.17	ko:K01628,ko:K18256	ko00051,ko00624,ko01120,map00051,map00624,map01120	M00636	R01634,R02262	RC00569,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II,UPF0066
HFD3_k127_5059495_2	1037409.BJ6T_87480	8.827e-116	387.0	COG0247@1|root,COG0247@2|Bacteria,1R4HN@1224|Proteobacteria,2U3WW@28211|Alphaproteobacteria,3JXJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4
HFD3_k127_5059495_13	1231391.AMZF01000020_gene1928	3.637e-38	157.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5059495_8	626887.J057_07386	8.729e-54	203.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_5059495_7	264198.Reut_B5286	2.193e-56	211.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VP7Y@28216|Betaproteobacteria,1KBE5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5059495_11	1231391.AMZF01000094_gene98	4.065e-46	180.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5059495_9	439235.Dalk_2665	2.44e-49	190.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_5059495_10	1499680.CCFE01000023_gene2581	1.9e-48	188.0	COG1960@1|root,COG1960@2|Bacteria,1UX6T@1239|Firmicutes,4IJKC@91061|Bacilli,1ZM73@1386|Bacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_5059495_4	1120983.KB894572_gene3272	1.666e-78	276.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,1JQ4A@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_5059495_15	1121939.L861_12420	2.068e-12	68.0	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,1SJPR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-Transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
HFD3_k127_5059495_16	1380394.JADL01000003_gene4948	3.251e-12	68.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VEZC@28211|Alphaproteobacteria,2JU3P@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_N
HFD3_k127_5105626_4	436114.SYO3AOP1_0254	2.846e-27	117.0	COG0319@1|root,COG0319@2|Bacteria,2G5AR@200783|Aquificae	200783|Aquificae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HFD3_k127_5105626_1	880073.Calab_1379	7.712e-131	426.0	COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD3_k127_5105626_0	344747.PM8797T_03484	2.455e-141	460.0	COG0500@1|root,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes	203682|Planctomycetes	Q	Methylase involved in ubiquinone menaquinone	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HFD3_k127_5105626_2	1183438.GKIL_0590	3.283e-115	379.0	COG0535@1|root,COG0535@2|Bacteria,1G18X@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM radical SAM Cys-rich domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
HFD3_k127_5105626_3	525897.Dbac_1109	1.468e-43	167.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,42R7A@68525|delta/epsilon subdivisions,2WN7K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD3_k127_5112064_1	443152.MDG893_15080	2.542e-57	207.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RQJ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_5112064_0	1231391.AMZF01000063_gene1102	2.703e-126	424.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_5112064_2	1238190.AMQY01000011_gene2125	1.7e-28	125.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1S32J@1236|Gammaproteobacteria,1XJBM@135619|Oceanospirillales	135619|Oceanospirillales	I	enoyl-CoA hydratase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_5112064_3	690585.JNNU01000009_gene534	1.542e-17	94.0	COG1840@1|root,COG1840@2|Bacteria,1PGNJ@1224|Proteobacteria,2V7JA@28211|Alphaproteobacteria,4BDDZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_5128709_1	138119.DSY4014	1.045e-131	433.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2605J@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_5128709_3	264732.Moth_1959	4.761e-47	181.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,42H2F@68295|Thermoanaerobacterales	186801|Clostridia	C	FAD binding domain in molybdopterin dehydrogenase	-	-	1.17.1.4,1.17.1.5	ko:K13479,ko:K20445	ko00230,ko00760,ko01100,ko01120,map00230,map00760,map01100,map01120	M00546	R01720,R01768,R02103	RC00143,RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_5128709_2	2754.EH55_00110	1.177e-52	202.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.17.1.4,1.2.5.3,1.3.99.16	ko:K00087,ko:K03518,ko:K07302,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32470	Fer2,Fer2_2
HFD3_k127_5128709_0	1449126.JQKL01000016_gene2867	6.285e-179	586.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,26828@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_5139870_0	1499967.BAYZ01000036_gene2418	2.862e-235	733.0	COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_5139870_4	289376.THEYE_A0882	5.617e-34	138.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD3_k127_5139870_2	448385.sce7609	3.12e-124	414.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2YXGF@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD3_k127_5139870_1	880073.Calab_2684	1.711e-187	599.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD3_k127_5139870_3	1125863.JAFN01000001_gene2410	3.636e-123	407.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HFD3_k127_5152233_4	999423.HMPREF9161_01700	2.579e-13	80.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,4H3WS@909932|Negativicutes	909932|Negativicutes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HFD3_k127_5152233_3	1232410.KI421415_gene3038	1.228e-71	250.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,43SDZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HFD3_k127_5152233_1	1379698.RBG1_1C00001G1625	7.431e-86	294.0	COG0294@1|root,COG0294@2|Bacteria,2NNN7@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HFD3_k127_5152233_0	880072.Desac_1477	7.816e-282	876.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MQTC@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD3_k127_5152233_2	1304880.JAGB01000002_gene2320	8.275e-83	293.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HFD3_k127_5152233_5	1173027.Mic7113_3432	4.183e-12	69.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H7GW@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,CHAT,TPR_12,TPR_7,TPR_8
HFD3_k127_5152233_6	237368.SCABRO_03797	4.675e-06	49.0	293PF@1|root,2ZR54@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_51971_3	1206731.BAGB01000167_gene952	4.468e-127	416.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4FUUW@85025|Nocardiaceae	201174|Actinobacteria	E	Hydroxymethylglutaryl-CoA lyase	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HFD3_k127_51971_13	556269.ACDQ01000003_gene1380	8.743e-18	94.0	COG0715@1|root,COG0715@2|Bacteria,1R6DV@1224|Proteobacteria,2WBP9@28216|Betaproteobacteria,4767A@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_51971_10	926690.KE386573_gene796	4.932e-55	201.0	COG0600@1|root,arCOG00169@2157|Archaea,2XXW6@28890|Euryarchaeota,23WH6@183963|Halobacteria	183963|Halobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_51971_8	1227499.C493_00160	6.64e-68	240.0	COG1116@1|root,arCOG00193@2157|Archaea,2XXDP@28890|Euryarchaeota,23VWW@183963|Halobacteria	183963|Halobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_51971_11	1356854.N007_12880	2.971e-54	205.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepQ	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_51971_14	1232452.BAIB02000002_gene36	1.196e-13	83.0	COG0006@1|root,COG0006@2|Bacteria,1VS27@1239|Firmicutes,24A4K@186801|Clostridia	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_51971_2	748247.AZKH_p0140	2.712e-141	461.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HFD3_k127_51971_9	1382306.JNIM01000001_gene1022	1.135e-62	219.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_51971_0	1382306.JNIM01000001_gene1023	6.709e-310	969.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_51971_5	1382306.JNIM01000001_gene1024	2.026e-106	354.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_51971_4	1134413.ANNK01000091_gene78	7.763e-111	374.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,1ZR0K@1386|Bacillus	91061|Bacilli	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_51971_7	189753.AXAS01000041_gene2534	3.171e-83	291.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_51971_6	768704.Desmer_3130	1.044e-95	330.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,260E4@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	ubiD	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_51971_1	760568.Desku_0802	5.817e-164	540.0	COG1042@1|root,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,260BP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD3_k127_51971_15	1246448.ANAZ01000030_gene4594	7.014e-07	52.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_51971_12	316067.Geob_1869	2.287e-31	141.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,43TYF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iAF987.Gmet_2474	OstA,OstA_2,OstA_C
HFD3_k127_521124_9	1356854.N007_16800	5.303e-09	58.0	COG0043@1|root,COG0043@2|Bacteria	2|Bacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_521124_0	76114.ebA5622	7.13e-162	541.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_521124_6	1173263.Syn7502_03004	1.09e-44	175.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_521124_5	1231391.AMZF01000046_gene961	3.116e-53	202.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_521124_2	1097668.BYI23_C003130	3.047e-98	342.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2WBWM@28216|Betaproteobacteria,1K6TM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_521124_8	977880.RALTA_A1928	2.66e-11	75.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria,1K2JX@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM NMT1 THI5 like domain protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_521124_1	216596.pRL80025	1.916e-158	528.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,4BME9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
HFD3_k127_521124_4	706587.Desti_1839	1.579e-53	195.0	COG2080@1|root,COG2080@2|Bacteria,1Q9C0@1224|Proteobacteria,42TB7@68525|delta/epsilon subdivisions,2WPGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_521124_3	411902.CLOBOL_05482	3.48e-61	219.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,2222K@1506553|Lachnoclostridium	186801|Clostridia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_5275465_12	1537994.JQFW01000056_gene742	0.0003345	45.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4650W@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	prsR	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5275465_7	1242864.D187_002482	6.985e-35	142.0	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_5275465_0	330214.NIDE1291	2.012e-233	741.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD3_k127_5275465_2	644966.Tmar_0214	1.126e-104	357.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD3_k127_5275465_9	237368.SCABRO_01528	4.026e-12	74.0	COG0457@1|root,COG0457@2|Bacteria	237368.SCABRO_01528|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5275465_6	398767.Glov_1258	1.654e-44	171.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,42R3K@68525|delta/epsilon subdivisions,2WJNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD3_k127_5275465_5	443152.MDG893_15462	2.258e-54	198.0	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,1RYRR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_5275465_11	1869.MB27_37250	1.793e-08	66.0	COG0715@1|root,COG0715@2|Bacteria,2HWR0@201174|Actinobacteria,4DIIZ@85008|Micromonosporales	201174|Actinobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_5275465_1	1380391.JIAS01000012_gene3985	1.058e-115	383.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,2JUDH@204441|Rhodospirillales	204441|Rhodospirillales	L	Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD3_k127_5275465_4	251229.Chro_4001	1.016e-66	235.0	COG0625@1|root,COG0625@2|Bacteria,1G34I@1117|Cyanobacteria,3VHY7@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
HFD3_k127_5275465_10	452637.Oter_1629	1.039e-09	59.0	COG0266@1|root,COG0266@2|Bacteria	2|Bacteria	L	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD3_k127_5275465_13	1233951.IO90_02760	0.0008007	44.0	2BWKX@1|root,33G81@2|Bacteria,4NYKR@976|Bacteroidetes,1IB9A@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD3_k127_5275465_8	1184609.KILIM_004_01350	3.238e-17	84.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HFD3_k127_5275465_3	349521.HCH_02013	2.129e-93	311.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD3_k127_5279191_6	883126.HMPREF9710_05024	5.576e-91	307.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VPBK@28216|Betaproteobacteria,476GH@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD3_k127_5279191_9	1071085.KK033114_gene736	1.133e-40	159.0	arCOG08934@1|root,arCOG08934@2157|Archaea,2XXBA@28890|Euryarchaeota	28890|Euryarchaeota	Q	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_5279191_7	864073.HFRIS_000685	1.215e-79	279.0	COG1073@1|root,COG1073@2|Bacteria,1PJHS@1224|Proteobacteria,2VXXE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0255 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
HFD3_k127_5279191_14	1232437.KL662020_gene793	1.555e-06	59.0	COG0715@1|root,COG0715@2|Bacteria,1PEB1@1224|Proteobacteria,42PTA@68525|delta/epsilon subdivisions,2WM25@28221|Deltaproteobacteria,2MIGF@213118|Desulfobacterales	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5279191_4	1131269.AQVV01000020_gene2195	8.254e-121	398.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_5279191_2	1131269.AQVV01000020_gene2194	1.837e-151	485.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	oppB	-	-	ko:K02033,ko:K13894	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HFD3_k127_5279191_1	1469245.JFBG01000011_gene839	1.898e-202	652.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria	1224|Proteobacteria	E	ABC-Type Dipeptide Transport System Periplasmic Component	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_5279191_13	290397.Adeh_4035	1.14e-17	96.0	COG2834@1|root,COG2834@2|Bacteria,1NMTC@1224|Proteobacteria,42XC3@68525|delta/epsilon subdivisions,2WT97@28221|Deltaproteobacteria,2YWF6@29|Myxococcales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HFD3_k127_5279191_5	644282.Deba_1896	1.669e-94	331.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
HFD3_k127_5279191_0	243231.GSU0890	1.284e-231	735.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HFD3_k127_5279191_11	330214.NIDE3327	2.948e-31	125.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD3_k127_5279191_12	429009.Adeg_1796	3.528e-29	119.0	COG1254@1|root,COG1254@2|Bacteria,1UEN2@1239|Firmicutes,25JM5@186801|Clostridia,42HJX@68295|Thermoanaerobacterales	186801|Clostridia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HFD3_k127_5279191_8	671143.DAMO_1544	6.879e-75	271.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HFD3_k127_5279191_3	330214.NIDE3942	4.718e-139	457.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5279191_10	292459.STH3254	1.519e-34	137.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD3_k127_529363_4	330214.NIDE1522	2.596e-60	215.0	COG0637@1|root,COG0637@2|Bacteria,3J15X@40117|Nitrospirae	40117|Nitrospirae	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD3_k127_529363_3	671143.DAMO_3020	1.605e-60	213.0	COG1051@1|root,COG2138@1|root,COG1051@2|Bacteria,COG2138@2|Bacteria,2NPZ5@2323|unclassified Bacteria	2|Bacteria	F	NUDIX domain	cbiX	-	1.1.1.169,3.1.3.25,3.6.1.55,4.99.1.3	ko:K00077,ko:K01092,ko:K03574,ko:K03795	ko00521,ko00562,ko00770,ko00860,ko01100,ko01110,ko01120,ko04070,map00521,map00562,map00770,map00860,map01100,map01110,map01120,map04070	M00119,M00131	R01185,R01186,R01187,R02472,R05807	RC00078,RC00726,RC01012	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CbiX,NUDIX
HFD3_k127_529363_7	330214.NIDE2482	7.976e-28	116.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HFD3_k127_529363_2	330214.NIDE1059	2.422e-63	231.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
HFD3_k127_529363_8	243231.GSU3447	7.169e-16	78.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,43URV@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD3_k127_529363_6	243231.GSU3447	6.648e-32	127.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,43URV@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD3_k127_529363_1	335543.Sfum_3313	2.393e-66	238.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MQEZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD3_k127_529363_0	448385.sce7073	3.354e-113	380.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2WKGT@28221|Deltaproteobacteria,2Z2VK@29|Myxococcales	28221|Deltaproteobacteria	S	DinB superfamily	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_31
HFD3_k127_529363_5	714943.Mucpa_2596	6.203e-38	150.0	COG2343@1|root,COG2343@2|Bacteria,4NSIC@976|Bacteroidetes,1ITCE@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HFD3_k127_529363_9	338966.Ppro_3000	7.462e-13	70.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,43URV@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD3_k127_5295666_0	1172188.KB911821_gene1528	5.558e-91	319.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FE5K@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5295666_4	323259.Mhun_3173	1.946e-17	94.0	COG0235@1|root,arCOG04226@2157|Archaea,2XYQT@28890|Euryarchaeota,2N9R0@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_5295666_2	502025.Hoch_6765	1.348e-46	186.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2YUP1@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
HFD3_k127_5295666_3	425104.Ssed_2504	7.048e-30	128.0	COG2820@1|root,COG2820@2|Bacteria,1P0EC@1224|Proteobacteria,1RN3N@1236|Gammaproteobacteria,2QA5N@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HFD3_k127_5295666_1	439235.Dalk_4040	1.585e-66	242.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42S94@68525|delta/epsilon subdivisions,2WNCW@28221|Deltaproteobacteria,2MNBQ@213118|Desulfobacterales	1224|Proteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HFD3_k127_5295666_5	272134.KB731324_gene1356	7.587e-15	83.0	COG1846@1|root,COG1846@2|Bacteria,1G61S@1117|Cyanobacteria,1HHCB@1150|Oscillatoriales	1117|Cyanobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD3_k127_5295666_6	509635.N824_20875	0.0001278	45.0	COG1234@1|root,COG1234@2|Bacteria,4NPMB@976|Bacteroidetes	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD3_k127_5311334_4	929562.Emtol_0411	1.483e-44	174.0	COG1368@1|root,COG1368@2|Bacteria,4NIAA@976|Bacteroidetes,47MRX@768503|Cytophagia	976|Bacteroidetes	M	Sulfatase	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
HFD3_k127_5311334_6	671143.DAMO_0872	9.492e-28	122.0	COG2267@1|root,COG2267@2|Bacteria,2NRR1@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD3_k127_5311334_0	1380394.JADL01000021_gene1881	2.623e-76	259.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_5311334_1	469383.Cwoe_1854	4.922e-70	248.0	COG4034@1|root,COG4034@2|Bacteria	2|Bacteria	F	Protein of unknown function (DUF1152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1152
HFD3_k127_5311334_3	395963.Bind_0556	1.513e-52	201.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2U2MU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_5311334_2	1379698.RBG1_1C00001G0620	4.291e-67	244.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_5311334_5	667014.Thein_0067	9.839e-31	127.0	2D7FD@1|root,32TNY@2|Bacteria,2GHX6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
HFD3_k127_5311476_2	477974.Daud_0866	1.234e-202	652.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HFD3_k127_5311476_0	1382356.JQMP01000004_gene488	0.0	1013.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HFD3_k127_5311476_4	706587.Desti_0523	2.24e-143	469.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MQ4P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HFD3_k127_5311476_3	671143.DAMO_0699	1.274e-183	582.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
HFD3_k127_5311476_1	880072.Desac_0215	7.56e-322	1005.0	COG1449@1|root,COG1449@2|Bacteria,1PUYM@1224|Proteobacteria,42MQP@68525|delta/epsilon subdivisions,2WKP2@28221|Deltaproteobacteria,2MQ8B@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
HFD3_k127_53520_0	290397.Adeh_2304	1.778e-199	648.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_53520_7	59374.Fisuc_1084	2.064e-09	69.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_53520_4	1283283.ATXA01000021_gene2854	7.665e-24	111.0	COG0235@1|root,COG0235@2|Bacteria,2HGGU@201174|Actinobacteria,4EWNJ@85013|Frankiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_53520_2	706587.Desti_3491	3.359e-40	169.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MRE3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	succinate dehydrogenase or fumarate reductase, flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD3_k127_53520_6	385682.AFSL01000012_gene2817	4.1e-12	70.0	COG1143@1|root,COG1143@2|Bacteria,4P63Y@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HFD3_k127_53520_3	671143.DAMO_3146	1.735e-27	112.0	2DP6Q@1|root,330SE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_53520_5	1541065.JRFE01000014_gene1822	7.684e-14	73.0	2EPME@1|root,314BN@2|Bacteria,1GIC0@1117|Cyanobacteria,3VNDM@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_53520_1	706587.Desti_0832	8.283e-92	321.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,43CS4@68525|delta/epsilon subdivisions,2X7ZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	2.7.7.58,6.3.2.14	ko:K02363,ko:K04116	ko00362,ko01053,ko01110,ko01120,ko01130,map00362,map01053,map01110,map01120,map01130	M00540	R05620,R07644	RC00004,RC00162,RC01438,RC03046	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5366976_26	1125863.JAFN01000001_gene3315	2.243e-81	276.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD3_k127_5366976_6	335543.Sfum_1575	1.036e-199	629.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MQSV@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD3_k127_5366976_49	1274374.CBLK010000085_gene4631	1.799e-48	178.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli,26WST@186822|Paenibacillaceae	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD3_k127_5366976_31	1121918.ARWE01000001_gene2256	5.104e-66	229.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,43SEU@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S5, C-terminal domain	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HFD3_k127_5366976_59	1254432.SCE1572_45645	7.282e-32	128.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2YVEW@29|Myxococcales	28221|Deltaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD3_k127_5366976_43	1089549.AZUQ01000001_gene1760	1.192e-56	202.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4EYIW@85014|Glycomycetales	201174|Actinobacteria	J	Ribosomal protein L6	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HFD3_k127_5366976_56	880072.Desac_1442	1.197e-37	145.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MQJ8@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HFD3_k127_5366976_67	316067.Geob_3612	3.683e-20	94.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,43VH4@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HFD3_k127_5366976_28	316067.Geob_3613	4.293e-77	263.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,43TH5@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HFD3_k127_5366976_58	335543.Sfum_1566	2.347e-34	134.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2WQ2G@28221|Deltaproteobacteria,2MS2M@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HFD3_k127_5366976_38	316067.Geob_3615	1.066e-60	211.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HFD3_k127_5366976_62	632335.Calkr_1751	1.051e-27	115.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42GX3@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HFD3_k127_5366976_73	498761.HM1_1386	6.251e-10	62.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HFD3_k127_5366976_42	391615.ABSJ01000049_gene1561	1.815e-58	205.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1JA22@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HFD3_k127_5366976_20	1232410.KI421428_gene1236	8.265e-101	332.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,43T5Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD3_k127_5366976_57	1232410.KI421428_gene1235	1.375e-36	141.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,43UWJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD3_k127_5366976_55	555779.Dthio_PD0323	1.076e-37	146.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MBZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD3_k127_5366976_17	1242864.D187_004835	1.467e-107	355.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2YTYD@29|Myxococcales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD3_k127_5366976_64	644282.Deba_2936	6.413e-26	110.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD3_k127_5366976_41	401526.TcarDRAFT_0999	3.785e-59	212.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4H24E@909932|Negativicutes	909932|Negativicutes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HFD3_k127_5366976_30	883.DvMF_0079	4.371e-70	243.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2M9CC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HFD3_k127_5366976_50	644282.Deba_2939	2.966e-48	173.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HFD3_k127_5366976_2	338966.Ppro_0677	0.0	1080.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,43SV3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD3_k127_5366976_37	404589.Anae109_1908	5.453e-61	213.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria,2YUYC@29|Myxococcales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD3_k127_5366976_34	398767.Glov_1341	2.911e-62	215.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,43URA@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	With S4 and S5 plays an important role in translational accuracy	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD3_k127_5366976_0	243231.GSU2862	0.0	2086.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HFD3_k127_5366976_1	316067.Geob_3632	0.0	1924.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HFD3_k127_5366976_54	1123325.JHUV01000003_gene1576	3.035e-42	163.0	COG0222@1|root,COG0222@2|Bacteria,2G42K@200783|Aquificae	200783|Aquificae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HFD3_k127_5366976_61	637390.AFOH01000118_gene330	3.942e-29	124.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,2NCDU@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HFD3_k127_5366976_22	795359.TOPB45_0167	1.003e-95	318.0	COG0081@1|root,COG0081@2|Bacteria,2GH9C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HFD3_k127_5366976_35	1121459.AQXE01000006_gene265	1.058e-61	214.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,2MB3K@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HFD3_k127_5366976_27	335543.Sfum_1544	6.503e-78	263.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2MQF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HFD3_k127_5366976_72	649747.HMPREF0083_00908	1.683e-10	65.0	COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,4HR1W@91061|Bacilli,26ZXQ@186822|Paenibacillaceae	91061|Bacilli	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HFD3_k127_5366976_69	1485545.JQLW01000001_gene1478	1.682e-15	77.0	COG0267@1|root,COG0267@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HFD3_k127_5366976_5	338966.Ppro_0678	3.265e-222	692.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,43U3Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HFD3_k127_5366976_40	880072.Desac_2554	1.706e-59	214.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2WPA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD3_k127_5366976_33	316067.Geob_1523	1.018e-64	236.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,43T2W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM permease YjgP YjgQ family protein	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD3_k127_5366976_46	269799.Gmet_1248	1.98e-52	203.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,42N5X@68525|delta/epsilon subdivisions,2WJ3H@28221|Deltaproteobacteria,43TT8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD3_k127_5366976_51	523791.Kkor_0666	4.654e-46	171.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1XJHH@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HFD3_k127_5366976_48	1232410.KI421418_gene2289	1.241e-51	186.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2WP5M@28221|Deltaproteobacteria,43URM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L13	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD3_k127_5366976_66	1125863.JAFN01000001_gene3463	2.412e-21	96.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,42VDU@68525|delta/epsilon subdivisions,2WRAI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup-1	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD3_k127_5366976_3	880072.Desac_0419	0.0	1078.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD3_k127_5366976_7	1192034.CAP_8960	1.112e-197	623.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YUHC@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD3_k127_5366976_24	868864.Dester_0010	1.336e-92	307.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD3_k127_5366976_29	338963.Pcar_1690	4.829e-73	263.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,43SAW@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Bacterial trigger factor protein (TF) C-terminus	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD3_k127_5366976_65	1254432.SCE1572_44010	1.487e-25	109.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
HFD3_k127_5366976_75	31964.CMS0033	3.421e-05	49.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria,4FM2F@85023|Microbacteriaceae	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HFD3_k127_5366976_4	697281.Mahau_2356	4.939e-263	822.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HFD3_k127_5366976_36	266779.Meso_2921	4.01e-61	223.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2U6AN@28211|Alphaproteobacteria,43PC3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_5366976_9	266779.Meso_2926	2.491e-178	571.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_5366976_23	246969.TAM4_600	4.668e-95	325.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota	28890|Euryarchaeota	E	COG3842 ABC-type spermidine putrescine transport systems, ATPase components	-	-	3.6.3.29,3.6.3.30,3.6.3.55	ko:K02010,ko:K02017,ko:K15497	ko02010,map02010	M00189,M00190,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE,TOBE_2
HFD3_k127_5366976_10	1231391.AMZF01000063_gene1102	1.652e-176	569.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_5366976_19	1121090.KB894689_gene333	4.937e-101	335.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,1ZCC8@1386|Bacillus	91061|Bacilli	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_5366976_71	1207063.P24_13318	4.796e-11	67.0	COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2TVAR@28211|Alphaproteobacteria,2JYPI@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HFD3_k127_5366976_16	1182590.BN5_00876	1.334e-117	393.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD3_k127_5366976_32	935840.JAEQ01000019_gene2104	6.979e-66	235.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_5366976_44	1123288.SOV_1c06600	5.957e-55	198.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4H5AR@909932|Negativicutes	909932|Negativicutes	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HFD3_k127_5366976_8	1449126.JQKL01000016_gene2867	1.435e-184	604.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,26828@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_5366976_60	940282.CADQ01000031_gene1924	1.156e-31	132.0	COG3391@1|root,COG3391@2|Bacteria,1R78P@1224|Proteobacteria,2U3BG@28211|Alphaproteobacteria,2JW9N@204441|Rhodospirillales	204441|Rhodospirillales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5366976_12	1380394.JADL01000022_gene4	1.137e-138	454.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JW26@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HFD3_k127_5366976_25	1410620.SHLA_34c000820	1.44e-83	295.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TSZ0@28211|Alphaproteobacteria,4BCJN@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_5366976_45	1205680.CAKO01000006_gene3183	7.379e-54	198.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2TTSB@28211|Alphaproteobacteria,2JPQH@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD3_k127_5366976_18	1382356.JQMP01000003_gene1487	2.006e-105	357.0	COG0624@1|root,COG0624@2|Bacteria,2GBDE@200795|Chloroflexi,27YXE@189775|Thermomicrobia	189775|Thermomicrobia	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD3_k127_5366976_52	574087.Acear_0893	6.81e-46	172.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,3WAIW@53433|Halanaerobiales	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
HFD3_k127_5366976_15	760568.Desku_3124	1.356e-126	415.0	COG2828@1|root,COG2828@2|Bacteria,1TPP6@1239|Firmicutes,24E0P@186801|Clostridia,264H2@186807|Peptococcaceae	186801|Clostridia	S	PFAM PrpF protein	-	-	5.3.3.6	ko:K20451	ko00760,ko01120,map00760,map01120	-	R03070	RC00844	ko00000,ko00001,ko01000	-	-	-	PrpF
HFD3_k127_5366976_14	1411123.JQNH01000001_gene3853	2.993e-130	430.0	COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VF0S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	extracellular solute-binding protein, family 1	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
HFD3_k127_5366976_11	398578.Daci_4800	9.292e-173	559.0	COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VK7P@28216|Betaproteobacteria,4AD6E@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_5366976_21	335543.Sfum_3496	3.902e-99	335.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2MRN0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HFD3_k127_5366976_53	1541065.JRFE01000014_gene1448	1.55e-45	179.0	COG0642@1|root,COG2205@2|Bacteria,1G0GI@1117|Cyanobacteria,3VHM7@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,Response_reg
HFD3_k127_5366976_13	330214.NIDE1585	6.488e-138	453.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	2|Bacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5366976_63	1163617.SCD_n01225	5.256e-27	128.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	fleR	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5366976_39	330214.NIDE0964	3.633e-60	227.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5366976_47	489825.LYNGBM3L_54460	1.001e-51	194.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,1HAC9@1150|Oscillatoriales	1117|Cyanobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_5366976_68	1454202.PPBDW_130097___1	1.875e-16	92.0	COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,1RNF0@1236|Gammaproteobacteria,1XTRW@135623|Vibrionales	135623|Vibrionales	EGP	of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_5366976_76	4929.XP_001484763.1	4.019e-05	55.0	COG5036@1|root,COG5264@1|root,KOG1161@2759|Eukaryota,KOG4580@2759|Eukaryota,38D0A@33154|Opisthokonta,3NU6V@4751|Fungi,3QJDY@4890|Ascomycota,3RSBP@4891|Saccharomycetes,47BG3@766764|Debaryomycetaceae	4751|Fungi	OPU	VTC domain	VTC4	GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0000822,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005783,GO:0006082,GO:0006793,GO:0006796,GO:0006797,GO:0006799,GO:0006810,GO:0006914,GO:0006996,GO:0007033,GO:0007034,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009056,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016237,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019932,GO:0023052,GO:0031090,GO:0031224,GO:0031300,GO:0031310,GO:0032991,GO:0033254,GO:0035556,GO:0036094,GO:0042144,GO:0043167,GO:0043168,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0048016,GO:0048284,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0061024,GO:0061025,GO:0061919,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0097576,GO:0098588,GO:0098805,GO:0098852,GO:0101031,GO:1901576	-	-	-	-	-	-	-	-	-	-	DUF202,SPX,VTC
HFD3_k127_5401806_9	1279009.ADICEAN_04015	4.352e-65	230.0	COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,47MB7@768503|Cytophagia	976|Bacteroidetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_5401806_18	1123242.JH636435_gene1534	4.047e-19	97.0	COG0457@1|root,COG0457@2|Bacteria	1123242.JH636435_gene1534|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5401806_5	1121106.JQKB01000008_gene1361	4.848e-78	275.0	COG2141@1|root,COG2141@2|Bacteria,1N4HT@1224|Proteobacteria,2UEZB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_5401806_14	1114856.C496_11308	5.04e-24	108.0	COG3217@1|root,arCOG04766@2157|Archaea,2Y7HS@28890|Euryarchaeota,241HM@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HFD3_k127_5401806_6	1173027.Mic7113_2967	1.062e-75	267.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	2|Bacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_5401806_11	189753.AXAS01000004_gene956	6.816e-46	177.0	COG0457@1|root,COG0457@2|Bacteria,1NG0U@1224|Proteobacteria,2U0YA@28211|Alphaproteobacteria,3K0QN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HFD3_k127_5401806_10	203124.Tery_2349	1.772e-63	231.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
HFD3_k127_5401806_12	240015.ACP_1416	2.497e-35	152.0	COG1538@1|root,COG1538@2|Bacteria,3Y5F3@57723|Acidobacteria,2JK84@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD3_k127_5401806_7	671143.DAMO_1932	4.621e-75	271.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HFD3_k127_5401806_0	671143.DAMO_1933	0.0	1443.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD3_k127_5401806_16	1303518.CCALI_01175	8.631e-21	93.0	COG0607@1|root,32YCZ@2|Bacteria	2|Bacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HFD3_k127_5401806_4	118166.JH976537_gene3679	7.423e-85	286.0	COG0412@1|root,COG0412@2|Bacteria,1G3JS@1117|Cyanobacteria,1HA80@1150|Oscillatoriales	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_5401806_2	1499967.BAYZ01000016_gene6507	2.567e-97	328.0	COG1226@1|root,COG1226@2|Bacteria,2NP71@2323|unclassified Bacteria	2|Bacteria	U	Ion channel	kch	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HFD3_k127_5401806_17	243231.GSU1541	3.475e-19	90.0	COG1943@1|root,COG1943@2|Bacteria,1RBFM@1224|Proteobacteria,42QPI@68525|delta/epsilon subdivisions,2WMUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_5401806_8	1356854.N007_12890	7.517e-68	244.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HD58@91061|Bacilli	91061|Bacilli	E	Ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_5401806_13	1122915.AUGY01000118_gene6536	1.318e-24	116.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5401806_3	443152.MDG893_15040	2.85e-95	326.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria	1224|Proteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_5401806_19	1174684.EBMC1_17152	2.683e-05	55.0	COG0346@1|root,COG0346@2|Bacteria,1N491@1224|Proteobacteria,2UK4T@28211|Alphaproteobacteria,2K9ZZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase-like domain	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	-
HFD3_k127_5401806_15	1122915.AUGY01000020_gene6479	3.21e-22	108.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5437075_3	1131269.AQVV01000006_gene491	4.714e-145	468.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HFD3_k127_5437075_6	330214.NIDE0612	1.067e-47	175.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
HFD3_k127_5437075_2	926549.KI421517_gene1952	3.965e-162	520.0	COG1894@1|root,COG1894@2|Bacteria,4NFB5@976|Bacteroidetes,47NNF@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HFD3_k127_5437075_4	1191523.MROS_2032	4.182e-133	443.0	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	nuoG	-	1.12.1.2,1.6.5.3	ko:K00336,ko:K18006	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HFD3_k127_5437075_5	1131269.AQVV01000018_gene1931	1.504e-108	369.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD3_k127_5437075_8	1057002.KB905370_gene626	4.918e-24	108.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2UPN8@28211|Alphaproteobacteria,4BAY1@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD3_k127_5437075_7	671143.DAMO_2693	8.846e-32	128.0	COG0713@1|root,COG0713@2|Bacteria,2NPU2@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD3_k127_5437075_0	1125863.JAFN01000001_gene2410	2.691e-196	636.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HFD3_k127_5437075_1	1379698.RBG1_1C00001G1061	1.247e-178	572.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD3_k127_5438241_11	272134.KB731324_gene3608	4.611e-114	376.0	COG0115@1|root,COG0115@2|Bacteria,1G1GM@1117|Cyanobacteria,1H8CZ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD3_k127_5438241_20	251229.Chro_0225	2.415e-88	299.0	COG1209@1|root,COG1209@2|Bacteria,1G0RG@1117|Cyanobacteria,3VM0I@52604|Pleurocapsales	1117|Cyanobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD3_k127_5438241_17	330214.NIDE1616	9.365e-98	339.0	2DM57@1|root,31S0Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5438241_37	1047013.AQSP01000122_gene2228	1.941e-11	66.0	294GU@1|root,2ZRWK@2|Bacteria,2NRXQ@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5438241_1	251229.Chro_0226	5.09e-201	633.0	COG4310@1|root,COG4310@2|Bacteria,1G39N@1117|Cyanobacteria	1117|Cyanobacteria	M	Domain of unknown function (DUF4910)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47
HFD3_k127_5438241_22	1173028.ANKO01000018_gene1166	1.233e-79	271.0	COG1898@1|root,COG1898@2|Bacteria,1G3DC@1117|Cyanobacteria,1HAPT@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD3_k127_5438241_2	247490.KSU1_A0006	4.041e-188	596.0	COG0500@1|root,COG0500@2|Bacteria,2IXZ8@203682|Planctomycetes	203682|Planctomycetes	Q	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
HFD3_k127_5438241_26	1449976.KALB_4422	8.14e-55	209.0	COG0500@1|root,COG0500@2|Bacteria,2INXQ@201174|Actinobacteria,4EDFK@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD3_k127_5438241_6	317936.Nos7107_1298	1.119e-152	489.0	COG0451@1|root,COG0451@2|Bacteria,1G3FQ@1117|Cyanobacteria,1HJ9W@1161|Nostocales	1117|Cyanobacteria	GM	PFAM NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD3_k127_5438241_12	903818.KI912268_gene2844	1.032e-109	361.0	COG1208@1|root,COG1208@2|Bacteria,3Y2MI@57723|Acidobacteria	57723|Acidobacteria	JM	TIGRFAM glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HFD3_k127_5438241_5	326427.Cagg_1557	2.202e-156	505.0	COG1134@1|root,COG1134@2|Bacteria,2G7ZX@200795|Chloroflexi,3772I@32061|Chloroflexia	32061|Chloroflexia	GM	PFAM ABC transporter related	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran
HFD3_k127_5438241_14	234267.Acid_4640	5.339e-102	339.0	COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HFD3_k127_5438241_9	857087.Metme_1344	1.09e-115	396.0	COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,1XG4C@135618|Methylococcales	135618|Methylococcales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_5438241_19	1283300.ATXB01000001_gene1496	1.44e-91	312.0	COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,1T22W@1236|Gammaproteobacteria,1XG6P@135618|Methylococcales	135618|Methylococcales	V	FemAB family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HFD3_k127_5438241_8	338966.Ppro_2450	1.006e-119	398.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,43S9C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD3_k127_5438241_16	1121439.dsat_1278	6.831e-98	330.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria,2M9ER@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
HFD3_k127_5438241_18	1121413.JMKT01000015_gene249	1.224e-97	335.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria,2MA09@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HFD3_k127_5438241_31	880072.Desac_2192	1.936e-33	141.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,42QS3@68525|delta/epsilon subdivisions,2WMX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Capsular exopolysaccharide family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA
HFD3_k127_5438241_24	1232410.KI421413_gene654	1.329e-70	255.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,43SAE@69541|Desulfuromonadales	28221|Deltaproteobacteria	MU	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HFD3_k127_5438241_23	933262.AXAM01000037_gene884	1.074e-70	259.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria,2MIV6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HFD3_k127_5438241_30	639030.JHVA01000001_gene3748	1.234e-37	149.0	COG1596@1|root,COG1596@2|Bacteria,3Y824@57723|Acidobacteria,2JNCJ@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD3_k127_5438241_36	595494.Tola_0619	5.28e-14	80.0	COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,1S91B@1236|Gammaproteobacteria,1Y4K3@135624|Aeromonadales	135624|Aeromonadales	K	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components	rfaH	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
HFD3_k127_5438241_0	243231.GSU0489	1.836e-212	674.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,43SC2@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD3_k127_5438241_35	316067.Geob_2627	4.185e-15	79.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD3_k127_5438241_29	1304874.JAFY01000005_gene1321	2.514e-42	170.0	COG0739@1|root,COG0739@2|Bacteria,3TAYS@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD3_k127_5438241_10	1232410.KI421421_gene3664	2.846e-115	384.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,43SB0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	OB-fold nucleic acid binding domain	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD3_k127_5438241_7	243231.GSU1772	6.928e-152	493.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,43TEQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HFD3_k127_5438241_27	243231.GSU1773	1.059e-49	194.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,43SYX@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SH3_3
HFD3_k127_5438241_28	338966.Ppro_2411	2.25e-45	176.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,43T0S@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HFD3_k127_5438241_25	290397.Adeh_0666	7.399e-70	244.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2YV0E@29|Myxococcales	28221|Deltaproteobacteria	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HFD3_k127_5438241_4	439235.Dalk_1994	2.647e-157	514.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HFD3_k127_5438241_3	1231391.AMZF01000094_gene122	1.786e-180	582.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_5438241_32	393283.XP_007828300.1	1.71e-24	114.0	2CXHA@1|root,2RXGX@2759|Eukaryota,38DQZ@33154|Opisthokonta,3P12I@4751|Fungi,3QQ9J@4890|Ascomycota,212Z0@147550|Sordariomycetes	4751|Fungi	S	6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,F420_oxidored,NAD_binding_2
HFD3_k127_5438241_15	653733.Selin_2084	4.969e-99	333.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	fas6	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD3_k127_5438241_34	1382359.JIAL01000001_gene2769	8.035e-20	95.0	COG2259@1|root,COG2259@2|Bacteria,3Y4XF@57723|Acidobacteria,2JMZV@204432|Acidobacteriia	204432|Acidobacteriia	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD3_k127_5438241_21	330214.NIDE3564	5.114e-83	302.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
HFD3_k127_5438241_13	96561.Dole_3134	3.596e-109	360.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2WKVB@28221|Deltaproteobacteria,2MHKN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HFD3_k127_5443268_11	714961.BFZC1_01297	0.0003196	46.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,3IWDF@400634|Lysinibacillus	91061|Bacilli	P	NMT1-like family	ytlA	GO:0003674,GO:0005215	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5443268_8	93220.LV28_02775	3.632e-20	94.0	COG0346@1|root,COG0346@2|Bacteria,1N491@1224|Proteobacteria,2W22E@28216|Betaproteobacteria,1K74B@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_5443268_6	690585.JNNU01000008_gene3736	4.744e-43	169.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5443268_0	316058.RPB_4416	2.611e-200	649.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_5443268_5	1121423.JONT01000004_gene1654	1.486e-61	225.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,260GZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD3_k127_5443268_2	1131269.AQVV01000024_gene2368	1.079e-172	557.0	COG4166@1|root,COG4166@2|Bacteria	2|Bacteria	E	transmembrane transport	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385,iUMNK88_1353.UMNK88_1667	SBP_bac_5
HFD3_k127_5443268_7	1345697.M493_12455	2.174e-27	117.0	COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,4HKCS@91061|Bacilli,1WGEK@129337|Geobacillus	91061|Bacilli	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HFD3_k127_5443268_1	675635.Psed_3032	1.302e-175	563.0	COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4DXG8@85010|Pseudonocardiales	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD3_k127_5443268_3	675635.Psed_3034	2.201e-123	411.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_5443268_10	1122915.AUGY01000020_gene6479	1.47e-18	98.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5443268_4	443152.MDG893_15307	1.33e-73	260.0	2C1EV@1|root,33RW1@2|Bacteria,1R3AA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5443268_9	582402.Hbal_2609	4.018e-20	91.0	COG3836@1|root,COG3836@2|Bacteria,1PGC1@1224|Proteobacteria,2V8A5@28211|Alphaproteobacteria,440C5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD3_k127_5445600_5	378806.STAUR_2785	1.286e-57	207.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria,2Z03M@29|Myxococcales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD3_k127_5445600_2	765869.BDW_07030	3.743e-138	456.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2MSVI@213481|Bdellovibrionales,2WJ8S@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Mur ligase, middle domain	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD3_k127_5445600_3	1499967.BAYZ01000139_gene140	2.479e-92	316.0	COG1680@1|root,COG1680@2|Bacteria,2NPA1@2323|unclassified Bacteria	2|Bacteria	V	Beta-lactamase	nagA	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
HFD3_k127_5445600_4	1341151.ASZU01000025_gene2986	1.124e-64	232.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,4HAWT@91061|Bacilli,27B0F@186824|Thermoactinomycetaceae	91061|Bacilli	V	LD-carboxypeptidase	ykfA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HFD3_k127_5445600_10	404380.Gbem_0247	8.586e-18	86.0	COG2952@1|root,COG2952@2|Bacteria,1NKWU@1224|Proteobacteria,42XJT@68525|delta/epsilon subdivisions,2WSNN@28221|Deltaproteobacteria,43SST@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
HFD3_k127_5445600_6	404589.Anae109_3714	5.467e-41	153.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD3_k127_5445600_0	290397.Adeh_3594	1.202e-272	847.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD3_k127_5445600_1	690850.Desaf_0510	4.495e-151	489.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2M8JZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HFD3_k127_5445600_9	1203602.HMPREF1527_00322	9.304e-23	100.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CWB2@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HFD3_k127_5445600_8	1379281.AVAG01000033_gene484	1.083e-24	105.0	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MCGN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HFD3_k127_5445600_7	335543.Sfum_2999	2.309e-28	120.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,42TGI@68525|delta/epsilon subdivisions,2WQJU@28221|Deltaproteobacteria,2MQMB@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HFD3_k127_5446247_10	368407.Memar_0689	2.234e-26	120.0	COG1541@1|root,arCOG02624@2157|Archaea,2XW5Z@28890|Euryarchaeota	28890|Euryarchaeota	H	COG1541 Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HFD3_k127_5446247_5	620914.JH621297_gene3504	6.913e-50	200.0	COG0457@1|root,COG0457@2|Bacteria,4NI5H@976|Bacteroidetes,1I5EH@117743|Flavobacteriia,2YHT2@290174|Aquimarina	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
HFD3_k127_5446247_6	102125.Xen7305DRAFT_00021700	4.36e-43	167.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,3VIPW@52604|Pleurocapsales	1117|Cyanobacteria	IQ	PFAM short chain dehydrogenase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_5446247_12	398767.Glov_2096	2.305e-15	81.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	gspG	-	-	ko:K02456,ko:K02650,ko:K02655	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	ComP_DUS,N_methyl,T2SSG
HFD3_k127_5446247_3	333138.LQ50_20165	2.158e-84	292.0	2A6Y1@1|root,30VSZ@2|Bacteria,1UBKQ@1239|Firmicutes,4IN0U@91061|Bacilli,1ZMG5@1386|Bacillus	91061|Bacilli	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_5446247_4	502025.Hoch_0434	7.517e-68	244.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria	1224|Proteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD3_k127_5446247_1	479434.Sthe_3486	6.462e-93	328.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5446247_2	240015.ACP_0714	3.94e-86	293.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	MA20_27970	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_5446247_9	289377.HL41_03355	1.213e-29	123.0	COG0589@1|root,COG0589@2|Bacteria,2GI5H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_5446247_0	289377.HL41_03360	6.508e-148	478.0	COG0475@1|root,COG0475@2|Bacteria	2|Bacteria	P	glutathione-regulated potassium exporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD3_k127_5446247_7	42256.RradSPS_2004	1.231e-41	168.0	COG4398@1|root,COG4398@2|Bacteria,2I3VH@201174|Actinobacteria,4CQGG@84995|Rubrobacteria	84995|Rubrobacteria	S	FIST_C	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HFD3_k127_5446247_8	1170562.Cal6303_0182	1.748e-31	129.0	COG0642@1|root,COG2205@2|Bacteria,1G0GI@1117|Cyanobacteria,1HM7F@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,Response_reg
HFD3_k127_5446247_11	1172188.KB911822_gene707	7.321e-25	116.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HFD3_k127_5446247_13	1408422.JHYF01000001_gene2684	1.542e-12	72.0	COG0346@1|root,COG0346@2|Bacteria,1V422@1239|Firmicutes,24JKI@186801|Clostridia,36K8C@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K21252	-	-	-	-	ko00000,ko01504	-	-	-	Glyoxalase
HFD3_k127_5459591_20	237368.SCABRO_00534	8.907e-08	55.0	COG3794@1|root,COG3794@2|Bacteria,2J29W@203682|Planctomycetes	2|Bacteria	C	Polysaccharide lyase family 4, domain II	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HFD3_k127_5459591_19	1034769.KB910518_gene2667	3.924e-11	68.0	COG2197@1|root,COG2197@2|Bacteria,1V37R@1239|Firmicutes,4IPRN@91061|Bacilli,2762H@186822|Paenibacillaceae	91061|Bacilli	KT	Chemotaxis protein CheY	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD3_k127_5459591_7	671143.DAMO_0818	1.752e-105	351.0	COG3005@1|root,COG3005@2|Bacteria,2NQ90@2323|unclassified Bacteria	2|Bacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	ko:K08354	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C554,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1
HFD3_k127_5459591_6	671143.DAMO_0819	6.429e-106	372.0	COG3637@1|root,COG3637@2|Bacteria,2NQC8@2323|unclassified Bacteria	2|Bacteria	M	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	Ail_Lom,MtrB_PioB
HFD3_k127_5459591_17	1379270.AUXF01000004_gene3289	8.873e-15	79.0	COG2010@1|root,COG2010@2|Bacteria,1ZUYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_5459591_16	926569.ANT_24800	9.907e-28	120.0	COG3303@1|root,COG3303@2|Bacteria,2GBNG@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HFD3_k127_5459591_1	1379698.RBG1_1C00001G0855	1.049e-163	544.0	COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	qrcB	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_5459591_11	1379698.RBG1_1C00001G0856	6.409e-90	301.0	COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HFD3_k127_5459591_0	1379698.RBG1_1C00001G0857	3.897e-167	536.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5459591_9	1379698.RBG1_1C00001G0858	3.434e-92	320.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD3_k127_5459591_10	1379698.RBG1_1C00001G0858	2.532e-90	312.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HFD3_k127_5459591_3	671143.DAMO_0822	2.504e-123	409.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HFD3_k127_5459591_15	671143.DAMO_0820	4.55e-53	192.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HFD3_k127_5459591_2	671143.DAMO_0821	1.026e-145	471.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HFD3_k127_5459591_8	452637.Oter_2603	2.935e-103	350.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HFD3_k127_5459591_14	354242.CJJ81176_0064	4.36e-67	239.0	COG0607@1|root,COG2864@1|root,COG0607@2|Bacteria,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2YNHB@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CP	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD3_k127_5459591_4	290397.Adeh_2002	5.707e-121	400.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HFD3_k127_5459591_12	290397.Adeh_2001	2.39e-78	269.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD3_k127_5459591_5	290397.Adeh_1998	3.069e-115	394.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HFD3_k127_5459591_13	290397.Adeh_1997	4.862e-78	267.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42PU2@68525|delta/epsilon subdivisions,2X60T@28221|Deltaproteobacteria,2Z327@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD3_k127_5476018_1	351607.Acel_0883	2.19e-98	333.0	COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,4EVT7@85013|Frankiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1,3.5.5.7	ko:K01501,ko:K01502	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05358,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC01336,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD3_k127_5476018_5	1397278.AYMV01000007_gene264	1.158e-10	73.0	COG0715@1|root,COG0715@2|Bacteria,2GMEC@201174|Actinobacteria,4FM7U@85023|Microbacteriaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1
HFD3_k127_5476018_6	104623.Ser39006_03522	5.988e-06	58.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RRP5@1236|Gammaproteobacteria,402YS@613|Serratia	1236|Gammaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5476018_2	247633.GP2143_09395	1.982e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,1RXZH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_5476018_0	1121396.KB893066_gene1571	1.116e-173	576.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD3_k127_5476018_3	1330700.JQNC01000003_gene911	5.13e-72	251.0	COG3258@1|root,COG3258@2|Bacteria,1WMNM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_5476018_4	479434.Sthe_2790	3.793e-16	83.0	COG0477@1|root,COG0477@2|Bacteria,2G5YG@200795|Chloroflexi,27XKV@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_5480696_4	1187851.A33M_1062	4.569e-86	293.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,3FDY7@34008|Rhodovulum	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD3_k127_5480696_6	158189.SpiBuddy_0412	5.865e-41	164.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5480696_2	1042326.AZNV01000012_gene1943	3.092e-121	409.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,4BAT1@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_5480696_3	1122915.AUGY01000118_gene6533	1.637e-107	359.0	COG0715@1|root,COG0715@2|Bacteria,1VRJ0@1239|Firmicutes,4HV8W@91061|Bacilli,26U3V@186822|Paenibacillaceae	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5480696_7	485913.Krac_8034	1.118e-38	149.0	COG3467@1|root,COG3467@2|Bacteria,2G70M@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD3_k127_5480696_1	671143.DAMO_1298	3.519e-146	476.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5480696_8	1485545.JQLW01000010_gene1620	6.594e-33	131.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator, receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD3_k127_5480696_5	237368.SCABRO_02085	2.841e-46	173.0	COG0614@1|root,COG0614@2|Bacteria,2J06G@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HFD3_k127_5480696_0	1502851.FG93_00182	1.338e-318	1039.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
HFD3_k127_5493178_10	1124991.MU9_257	8.67e-27	113.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291	Thioredoxin
HFD3_k127_5493178_2	706587.Desti_2023	1.713e-179	577.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2WPN9@28221|Deltaproteobacteria,2MRFR@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_5493178_9	492774.JQMB01000014_gene1510	9.004e-51	183.0	COG0346@1|root,COG0346@2|Bacteria,1NZNJ@1224|Proteobacteria,2UTNS@28211|Alphaproteobacteria,4BEWN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_5493178_7	1267535.KB906767_gene3770	2.981e-66	236.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD3_k127_5493178_12	323848.Nmul_A1593	2.524e-19	93.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,2VSN7@28216|Betaproteobacteria,3734X@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_5493178_6	1459636.NTE_03091	8.467e-76	258.0	COG0431@1|root,arCOG04624@2157|Archaea,41T7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	S	NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HFD3_k127_5493178_8	1123393.KB891316_gene1263	1.019e-51	190.0	293J8@1|root,2ZR19@2|Bacteria,1R6Y4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5493178_1	234267.Acid_7913	1.52e-213	684.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,3Y9A3@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,GAF_3,HTH_8,Sigma54_activat
HFD3_k127_5493178_0	926550.CLDAP_06400	0.0	1090.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HFD3_k127_5493178_4	926550.CLDAP_05930	3.297e-98	325.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,cNMP_binding
HFD3_k127_5493178_3	1236902.ANAS01000001_gene1927	2.03e-147	485.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4EI2I@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HFD3_k127_5493178_5	330214.NIDE0246	9.032e-87	299.0	COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD3_k127_5493178_11	1205680.CAKO01000002_gene2637	7.11e-26	111.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2JPAV@204441|Rhodospirillales	204441|Rhodospirillales	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
HFD3_k127_5498969_1	105425.BBPL01000045_gene3219	1.108e-40	161.0	COG1032@1|root,COG1032@2|Bacteria,2GZU1@201174|Actinobacteria,2NI0T@228398|Streptacidiphilus	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5498969_4	706439.HMPREF9057_02496	3.08e-06	59.0	COG0715@1|root,COG0715@2|Bacteria,2HQ4M@201174|Actinobacteria,4D82Y@85005|Actinomycetales	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_5498969_0	1123508.JH636440_gene2821	1.25e-160	518.0	COG1696@1|root,COG1696@2|Bacteria,2IX06@203682|Planctomycetes	203682|Planctomycetes	M	membrane protein involved in D-alanine	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HFD3_k127_5498969_3	1500897.JQNA01000002_gene4715	3.642e-26	111.0	COG0695@1|root,COG0695@2|Bacteria,1RC6T@1224|Proteobacteria,2VQW9@28216|Betaproteobacteria,1K5H4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Glutaredoxin
HFD3_k127_5499592_10	903818.KI912269_gene527	1.901e-26	113.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183,2.3.1.82	ko:K03823,ko:K18816	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	br01600,ko00000,ko00001,ko01000,ko01504	-	-	-	Acetyltransf_1,Methyltransf_25
HFD3_k127_5499592_14	1380356.JNIK01000017_gene2825	1.569e-07	59.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HFD3_k127_5499592_1	479434.Sthe_2909	1.05e-141	465.0	COG1012@1|root,COG1012@2|Bacteria,2G7YU@200795|Chloroflexi,27Y0H@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD3_k127_5499592_6	1231391.AMZF01000094_gene98	3.386e-38	156.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5499592_11	1123288.SOV_3c04610	1.832e-23	111.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes	1239|Firmicutes	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_5499592_4	1087481.AGFX01000022_gene2212	3.813e-56	207.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,4HD40@91061|Bacilli,26W2Y@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the HpcH HpaI aldolase family	citE	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD3_k127_5499592_13	573064.Mefer_0551	2.593e-08	66.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT83@28890|Euryarchaeota,23Q2W@183939|Methanococci	183939|Methanococci	G	PFAM major facilitator superfamily MFS_1	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HFD3_k127_5499592_0	479434.Sthe_1794	1.604e-177	563.0	COG1960@1|root,COG1960@2|Bacteria,2G815@200795|Chloroflexi,27Z4U@189775|Thermomicrobia	189775|Thermomicrobia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_5499592_3	443143.GM18_3660	7.477e-61	214.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria	1224|Proteobacteria	I	Dehydratase	maoC	-	4.2.1.148,4.2.1.56	ko:K14449,ko:K18290	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R02491,R05076	RC00730,RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HFD3_k127_5499592_2	797303.Natpe_1336	2.042e-113	379.0	COG1804@1|root,arCOG02304@2157|Archaea,2XTW7@28890|Euryarchaeota,23SQV@183963|Halobacteria	183963|Halobacteria	C	Bile acid-inducible L-carnitine dehydratase protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_5499592_5	255470.cbdbA632	3.544e-41	158.0	COG1611@1|root,COG1611@2|Bacteria,2G9EJ@200795|Chloroflexi,34DB6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
HFD3_k127_5499592_12	1120963.KB894491_gene1124	1.084e-16	87.0	COG3453@1|root,COG3453@2|Bacteria,1N0WC@1224|Proteobacteria,1S8TP@1236|Gammaproteobacteria,2Q3TS@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
HFD3_k127_5499592_7	1120936.KB907221_gene2112	1.127e-37	154.0	COG2159@1|root,COG2159@2|Bacteria,2GN9D@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_5499592_9	207559.Dde_2523	3.022e-33	136.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,2ME45@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD3_k127_5499592_8	1396141.BATP01000060_gene4765	2.113e-33	142.0	COG0028@1|root,COG2730@1|root,COG2755@1|root,COG2931@1|root,COG3506@1|root,COG3637@1|root,COG4733@1|root,COG5184@1|root,COG0028@2|Bacteria,COG2730@2|Bacteria,COG2755@2|Bacteria,COG2931@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,46Z9Q@74201|Verrucomicrobia,2IVEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DEGMUZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
HFD3_k127_5499592_15	1349767.GJA_4248	7.893e-06	57.0	COG3291@1|root,COG4412@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,1MYCW@1224|Proteobacteria,2WF6V@28216|Betaproteobacteria,476HS@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA
HFD3_k127_5500104_15	443144.GM21_2878	5.937e-08	54.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions,2X5MB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_5500104_13	489825.LYNGBM3L_17170	4.603e-16	83.0	COG5555@1|root,COG5555@2|Bacteria,1GR73@1117|Cyanobacteria	2|Bacteria	N	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
HFD3_k127_5500104_6	198628.Dda3937_02137	1.566e-59	225.0	COG4124@1|root,COG4124@2|Bacteria,1Q17Q@1224|Proteobacteria,1RZFV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Glyco_hydro_26
HFD3_k127_5500104_17	1120797.KB908270_gene2912	0.0007093	49.0	2B9CY@1|root,322QQ@2|Bacteria,2H75I@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5500104_16	1173028.ANKO01000247_gene3999	7.285e-05	51.0	COG3420@1|root,COG3420@2|Bacteria,1G3CP@1117|Cyanobacteria,1H7VY@1150|Oscillatoriales	1117|Cyanobacteria	P	parallel beta-helix repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565
HFD3_k127_5500104_4	1121405.dsmv_1370	1.797e-98	329.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD3_k127_5500104_8	91604.ID47_09260	4.065e-38	150.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,47FFN@766|Rickettsiales	766|Rickettsiales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HFD3_k127_5500104_7	1499967.BAYZ01000068_gene1975	1.31e-50	186.0	COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HFD3_k127_5500104_1	398767.Glov_2173	3.65e-144	464.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HFD3_k127_5500104_12	269799.Gmet_0753	3.47e-20	91.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WRRS@28221|Deltaproteobacteria,43SRB@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HFD3_k127_5500104_0	1232410.KI421415_gene3124	7.912e-220	704.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43SDF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PAS domain	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HFD3_k127_5500104_2	909663.KI867151_gene3132	1.061e-117	392.0	COG0774@1|root,COG2204@1|root,COG0774@2|Bacteria,COG2204@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MRFZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	MT	UDP-3-O-acyl N-acetylglycosamine deacetylase	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
HFD3_k127_5500104_11	498848.TaqDRAFT_4728	6.899e-21	98.0	COG4911@1|root,COG4911@2|Bacteria,1WJWB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HFD3_k127_5500104_5	234267.Acid_3576	4.276e-92	317.0	COG1600@1|root,COG1600@2|Bacteria,3Y3TQ@57723|Acidobacteria	57723|Acidobacteria	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD3_k127_5500104_3	1192034.CAP_3447	3.623e-104	351.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,42RUS@68525|delta/epsilon subdivisions,2WNWT@28221|Deltaproteobacteria,2YWXA@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HFD3_k127_5500104_9	1267005.KB911257_gene674	8.415e-28	122.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,3N724@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1178)	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HFD3_k127_5500104_14	1283283.ATXA01000021_gene2856	2.248e-12	69.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HFD3_k127_5508099_4	266117.Rxyl_0933	1.03e-28	116.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria,4CRDV@84995|Rubrobacteria	84995|Rubrobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_5508099_1	266117.Rxyl_0933	1.81e-41	155.0	COG0620@1|root,COG0620@2|Bacteria,2I9RI@201174|Actinobacteria,4CRDV@84995|Rubrobacteria	84995|Rubrobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_5508099_5	1255043.TVNIR_2400	1.112e-27	122.0	COG0730@1|root,COG0730@2|Bacteria,1RJXP@1224|Proteobacteria,1S5MM@1236|Gammaproteobacteria,1WYSR@135613|Chromatiales	135613|Chromatiales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_5508099_2	1231391.AMZF01000069_gene2124	7.099e-41	156.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD3_k127_5508099_0	948106.AWZT01000001_gene5077	9.364e-134	448.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2WBWM@28216|Betaproteobacteria,1K6TM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_5508099_3	1173025.GEI7407_3711	7.933e-37	151.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1H7QZ@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD3_k127_552834_4	391165.GbCGDNIH1_0516	2.167e-61	223.0	COG0596@1|root,COG0596@2|Bacteria,1Q6ET@1224|Proteobacteria,2URHM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_6
HFD3_k127_552834_9	314275.MADE_1007985	4.635e-11	68.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,464ZI@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HFD3_k127_552834_1	671143.DAMO_3054	1.532e-110	381.0	COG5621@1|root,COG5621@2|Bacteria,2NPFN@2323|unclassified Bacteria	2|Bacteria	S	Lipocalin-like domain	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HFD3_k127_552834_3	1469245.JFBG01000009_gene565	3.326e-67	238.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RQNH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Rhodanese-like domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD3_k127_552834_6	671143.DAMO_1446	4.836e-49	182.0	COG0500@1|root,COG2226@2|Bacteria,2NPUA@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HFD3_k127_552834_5	671143.DAMO_1095	7.858e-56	202.0	COG1392@1|root,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HFD3_k127_552834_8	1232410.KI421420_gene3150	1.494e-14	75.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42V5P@68525|delta/epsilon subdivisions,2WRM0@28221|Deltaproteobacteria,43VW0@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD3_k127_552834_0	671143.DAMO_3115	2.778e-125	416.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD3_k127_552834_2	1125863.JAFN01000001_gene205	6.778e-97	332.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HFD3_k127_552834_7	251229.Chro_0360	6.511e-29	128.0	COG0392@1|root,COG0392@2|Bacteria,1G41A@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family (UPF0104)	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HFD3_k127_5567350_11	768706.Desor_1551	1.248e-05	50.0	28HF7@1|root,2ZAT5@2|Bacteria,1VT0D@1239|Firmicutes,24XG8@186801|Clostridia	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase component B subunits	-	-	-	-	-	-	-	-	-	-	-	-	Gly_reductase
HFD3_k127_5567350_1	768706.Desor_1550	3.733e-86	298.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia	186801|Clostridia	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2,1.21.4.4	ko:K10672,ko:K21579	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HFD3_k127_5567350_7	246194.CHY_2393	1.93e-20	93.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,42HVI@68295|Thermoanaerobacterales	186801|Clostridia	C	Glycine reductase complex component B subunit gamma	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HFD3_k127_5567350_3	768706.Desor_1551	8.362e-72	259.0	28HF7@1|root,2ZAT5@2|Bacteria,1VT0D@1239|Firmicutes,24XG8@186801|Clostridia	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase component B subunits	-	-	-	-	-	-	-	-	-	-	-	-	Gly_reductase
HFD3_k127_5567350_8	477184.KYC_09846	1.815e-13	81.0	COG4521@1|root,COG4521@2|Bacteria,1QVY3@1224|Proteobacteria,2VN3S@28216|Betaproteobacteria,3T2RS@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC transporter substrate-binding protein	-	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
HFD3_k127_5567350_9	340177.Cag_1786	9.076e-13	70.0	2BJMF@1|root,32DYT@2|Bacteria,1FF7D@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5567350_12	675635.Psed_1037	6.996e-05	53.0	COG3473@1|root,COG3473@2|Bacteria,2GKP7@201174|Actinobacteria,4DY88@85010|Pseudonocardiales	201174|Actinobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_5567350_5	1231391.AMZF01000046_gene961	1.177e-52	200.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5567350_2	573063.Metin_0714	1.324e-72	252.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,23QHW@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_5567350_6	1254432.SCE1572_23490	1.053e-39	160.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,437RC@68525|delta/epsilon subdivisions,2X304@28221|Deltaproteobacteria,2YTVQ@29|Myxococcales	28221|Deltaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PCMT
HFD3_k127_5567350_10	1041159.AZUW01000008_gene4443	1.493e-06	56.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
HFD3_k127_5567350_4	706587.Desti_1935	6.178e-58	207.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HFD3_k127_5567350_0	1123393.KB891326_gene87	6.313e-289	894.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD3_k127_5572818_0	547144.HydHO_1416	8.459e-206	649.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2G4N5@200783|Aquificae	200783|Aquificae	CI	RnfC Barrel sandwich hybrid domain	-	-	6.4.1.7	ko:K20140	-	-	-	-	ko00000,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HFD3_k127_5572818_5	675635.Psed_4160	1.587e-19	101.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_5572818_2	1231391.AMZF01000066_gene1898	8.362e-132	425.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,3T51K@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_5572818_1	311403.Arad_7168	2.698e-177	572.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4B7Q4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD3_k127_5572818_3	313624.NSP_48370	1.97e-54	216.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1HUAE@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
HFD3_k127_5572818_6	795359.TOPB45_1248	8.188e-15	78.0	COG2204@1|root,COG2204@2|Bacteria,2GH05@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5572818_7	311403.Arad_7168	0.000946	44.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4B7Q4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD3_k127_5572818_4	1547437.LL06_00335	1.559e-27	113.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,43IZ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_5585586_5	1121405.dsmv_2552	1.53e-21	96.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MHRE@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD3_k127_5585586_1	941449.dsx2_1232	1.754e-158	519.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD3_k127_5585586_0	671143.DAMO_1697	5.223e-212	670.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD3_k127_5585586_4	338963.Pcar_1500	1.714e-48	175.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,43SKG@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Nitrogen regulatory protein P-II	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD3_k127_5585586_2	1449126.JQKL01000045_gene1963	1.686e-81	280.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,269N4@186813|unclassified Clostridiales	186801|Clostridia	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HFD3_k127_5585586_3	1158345.JNLL01000001_gene2000	3.095e-49	188.0	COG0589@1|root,COG0589@2|Bacteria,2G4YU@200783|Aquificae	200783|Aquificae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_5594153_3	1122963.AUHB01000010_gene1525	3.872e-07	55.0	COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,2U7MU@28211|Alphaproteobacteria,370XI@31993|Methylocystaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HFD3_k127_5594153_4	1117108.PAALTS15_11599	3.143e-06	56.0	2DG3Y@1|root,2ZUD9@2|Bacteria,1W5J7@1239|Firmicutes,4ICTQ@91061|Bacilli,272SJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5594153_0	702113.PP1Y_Mpl8612	4.74e-65	233.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,2TTM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	rve
HFD3_k127_5594153_2	1297863.APJF01000033_gene1629	8.238e-17	90.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria,3JTAG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD3_k127_5611419_5	1144310.PMI07_005447	2.743e-44	174.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5611419_4	1144310.PMI07_005447	1.2e-53	202.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5611419_3	443152.MDG893_15467	1.15e-57	214.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5611419_2	146922.JOFU01000020_gene2529	1.948e-88	303.0	COG2355@1|root,COG2355@2|Bacteria	2|Bacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Dickkopf_N,Peptidase_M19,Ricin_B_lectin
HFD3_k127_5611419_0	589924.Ferp_0083	3.931e-188	606.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5611419_1	589924.Ferp_0082	3.132e-92	308.0	COG0410@1|root,arCOG00924@2157|Archaea,2XTUG@28890|Euryarchaeota,246XP@183980|Archaeoglobi	28890|Euryarchaeota	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HFD3_k127_5616686_6	1254432.SCE1572_51465	2.177e-42	159.0	COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2Z22Z@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD3_k127_5616686_3	290397.Adeh_2572	1.873e-74	253.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2Z08H@29|Myxococcales	28221|Deltaproteobacteria	C	Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD3_k127_5616686_4	404589.Anae109_1287	3.936e-50	187.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2Z1BP@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD3_k127_5616686_0	290397.Adeh_2574	5.399e-147	474.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YWJS@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HFD3_k127_5616686_1	448385.sce7563	9.45e-125	411.0	COG0265@1|root,COG1005@1|root,COG0265@2|Bacteria,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
HFD3_k127_5616686_5	1254432.SCE1572_46100	5.879e-48	177.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria,2Z0UI@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
HFD3_k127_5616686_7	448385.sce8025	1.143e-39	154.0	COG0839@1|root,COG0839@2|Bacteria,1PJW9@1224|Proteobacteria,42V0F@68525|delta/epsilon subdivisions,2WS8G@28221|Deltaproteobacteria,2Z1CQ@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD3_k127_5616686_8	290397.Adeh_2578	4.912e-32	129.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42WIQ@68525|delta/epsilon subdivisions,2WS3A@28221|Deltaproteobacteria,2Z1V8@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD3_k127_5616686_2	1125863.JAFN01000001_gene2410	6.958e-94	316.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HFD3_k127_5625975_5	156889.Mmc1_3232	2.747e-48	177.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Thioredoxin	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HFD3_k127_5625975_10	1120983.KB894575_gene726	0.0001026	48.0	COG1765@1|root,COG1765@2|Bacteria,1N0BA@1224|Proteobacteria,2UIZU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD3_k127_5625975_8	595460.RRSWK_06191	1.881e-11	66.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD3_k127_5625975_2	671143.DAMO_2127	1.736e-66	241.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD3_k127_5625975_6	1298867.AUES01000085_gene3659	4.148e-37	151.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_9	1037409.BJ6T_87360	6.013e-06	48.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_1	189753.AXAS01000041_gene2534	4.278e-72	256.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_4	189753.AXAS01000041_gene2534	1.778e-49	189.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_3	189753.AXAS01000041_gene2534	1.069e-57	211.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_7	1038866.KB902811_gene1833	2.629e-19	88.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5625975_0	443598.AUFA01000002_gene2563	4.269e-123	422.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HFD3_k127_5653280_0	251221.35214602	1.664e-203	644.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HFD3_k127_5653280_2	243231.GSU1610	1.481e-114	383.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD3_k127_5653280_4	880072.Desac_2223	4.121e-70	254.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42SGU@68525|delta/epsilon subdivisions,2WPBP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HFD3_k127_5653280_3	886293.Sinac_5029	1.898e-86	294.0	COG1878@1|root,COG1878@2|Bacteria,2IZXG@203682|Planctomycetes	203682|Planctomycetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD3_k127_5653280_5	1121440.AUMA01000009_gene689	0.0001189	51.0	COG0457@1|root,COG0457@2|Bacteria,1R51F@1224|Proteobacteria,42NP1@68525|delta/epsilon subdivisions,2WMJ3@28221|Deltaproteobacteria,2M89Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HFD3_k127_5653280_1	1382304.JNIL01000001_gene1506	1.511e-128	426.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,278QK@186823|Alicyclobacillaceae	91061|Bacilli	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_5653877_5	796606.BMMGA3_07950	1.669e-27	119.0	COG0584@1|root,COG3540@1|root,COG0584@2|Bacteria,COG3540@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1ZCIE@1386|Bacillus	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.3.1,3.1.4.46	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	GDPD
HFD3_k127_5653877_0	1088721.NSU_3368	2.411e-94	320.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,2U1NZ@28211|Alphaproteobacteria,2KEFF@204457|Sphingomonadales	204457|Sphingomonadales	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_5653877_6	485913.Krac_2132	5.18e-22	101.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	abmE	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD3_k127_5653877_4	1173263.Syn7502_03004	4.584e-34	144.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5653877_3	1173263.Syn7502_03004	1.304e-38	157.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5653877_2	1268068.PG5_42060	3.872e-39	158.0	COG0726@1|root,COG3195@1|root,COG0726@2|Bacteria,COG3195@2|Bacteria,1MV3V@1224|Proteobacteria,1RPKM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD3_k127_5653877_7	1231391.AMZF01000007_gene1511	7.231e-22	108.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2VZS3@28216|Betaproteobacteria	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_5653877_1	1187851.A33M_1060	4.033e-53	190.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3FE0S@34008|Rhodovulum	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_5679250_16	797299.HALLA_02515	1.029e-78	267.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAS@28890|Euryarchaeota,23SVB@183963|Halobacteria	183963|Halobacteria	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD3_k127_5679250_14	189753.AXAS01000041_gene2534	1.598e-82	286.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5679250_35	1123511.KB905865_gene1812	1.237e-10	74.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,Response_reg
HFD3_k127_5679250_19	234267.Acid_5241	7.652e-62	220.0	COG1262@1|root,COG1262@2|Bacteria	234267.Acid_5241|-	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5679250_7	1125973.JNLC01000011_gene547	1.583e-109	366.0	COG1149@1|root,COG1149@2|Bacteria,1QTYV@1224|Proteobacteria,2TTH3@28211|Alphaproteobacteria,3JV8K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	TIGRFAM CitB domain protein	tcuB	-	-	ko:K13795	-	-	-	-	ko00000	-	-	-	-
HFD3_k127_5679250_2	1380355.JNIJ01000070_gene5794	1.02e-190	607.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JQYS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HFD3_k127_5679250_4	65497.JODV01000031_gene1297	3.272e-168	550.0	COG3333@1|root,COG3333@2|Bacteria,2ICF3@201174|Actinobacteria,4DXD5@85010|Pseudonocardiales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_5679250_9	558169.AGAV01000018_gene3526	1.232e-96	329.0	COG3181@1|root,COG3181@2|Bacteria,1UY6C@1239|Firmicutes,4HERV@91061|Bacilli	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5679250_29	335543.Sfum_2110	1.913e-20	95.0	COG2329@1|root,COG2329@2|Bacteria,1Q37Z@1224|Proteobacteria,42WX0@68525|delta/epsilon subdivisions,2WTHF@28221|Deltaproteobacteria,2MSFV@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD3_k127_5679250_8	479434.Sthe_3372	1.923e-103	353.0	COG2079@1|root,COG2079@2|Bacteria,2G8X4@200795|Chloroflexi,27Z98@189775|Thermomicrobia	189775|Thermomicrobia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HFD3_k127_5679250_24	443152.MDG893_15467	8.434e-51	196.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5679250_37	1205680.CAKO01000026_gene4597	1.912e-07	55.0	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,2U3FR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_5679250_36	485913.Krac_1243	9.909e-09	60.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ynjA	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	CMD
HFD3_k127_5679250_13	472759.Nhal_1058	3.608e-89	302.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,1WYUF@135613|Chromatiales	135613|Chromatiales	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HFD3_k127_5679250_26	313612.L8106_13405	5.707e-47	178.0	COG1878@1|root,COG1878@2|Bacteria,1G60Q@1117|Cyanobacteria,1HHEV@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HFD3_k127_5679250_40	1243664.CAVL020000008_gene4243	4.531e-05	56.0	COG2510@1|root,COG2510@2|Bacteria,1V3VG@1239|Firmicutes,4HP13@91061|Bacilli,1ZDV1@1386|Bacillus	91061|Bacilli	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
HFD3_k127_5679250_25	488538.SAR116_0337	7.628e-49	181.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2U67Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HFD3_k127_5679250_27	467661.RKLH11_3177	8.963e-41	156.0	COG4032@1|root,COG4032@2|Bacteria,1RFK9@1224|Proteobacteria,2U75B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5679250_12	1056512.D515_02334	1.381e-89	314.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XU4R@135623|Vibrionales	135623|Vibrionales	C	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD3_k127_5679250_33	485913.Krac_1319	8.796e-14	77.0	COG3427@1|root,COG3427@2|Bacteria,2G6U6@200795|Chloroflexi	200795|Chloroflexi	NU	PFAM carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HFD3_k127_5679250_15	1382306.JNIM01000001_gene2693	4.969e-81	288.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_5679250_0	234267.Acid_2226	1.525e-279	879.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_5679250_18	479434.Sthe_1398	4.146e-69	238.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,27XMB@189775|Thermomicrobia	189775|Thermomicrobia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_5679250_30	1149133.ppKF707_6168	4.616e-20	96.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1YEVK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD3_k127_5679250_23	696369.KI912183_gene2825	1.718e-51	197.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD3_k127_5679250_10	370438.PTH_0791	1.896e-94	317.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,26123@186807|Peptococcaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
HFD3_k127_5679250_1	671143.DAMO_2373	1.012e-221	695.0	COG1012@1|root,COG1012@2|Bacteria,2NNW6@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD3_k127_5679250_11	398767.Glov_0049	2.099e-93	316.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,43T29@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HFD3_k127_5679250_28	1167006.UWK_01620	2.692e-29	121.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria,2MKPA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HFD3_k127_5679250_17	667014.Thein_1638	2.965e-69	241.0	COG0325@1|root,COG0325@2|Bacteria,2GH4Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HFD3_k127_5679250_31	1121324.CLIT_10c00260	1.841e-16	86.0	COG1978@1|root,COG1978@2|Bacteria,1UYNY@1239|Firmicutes,24G4U@186801|Clostridia	186801|Clostridia	S	d-proline reductase	prdB	-	1.21.4.1	ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
HFD3_k127_5679250_34	1125863.JAFN01000001_gene1072	5.829e-11	66.0	2DREH@1|root,33BDY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5679250_22	443152.MDG893_15295	2e-55	207.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5679250_21	443152.MDG893_15260	1.216e-55	208.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5679250_32	472759.Nhal_2252	2.379e-16	84.0	2DSEW@1|root,33FVA@2|Bacteria,1NIY7@1224|Proteobacteria,1STT8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5679250_6	1038859.AXAU01000026_gene2332	1.737e-113	373.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,3JRYA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_5679250_5	504832.OCAR_7524	1.122e-130	423.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	nikB	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_5679250_3	504832.OCAR_7523	4.063e-183	588.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_5679250_20	247490.KSU1_B0345	2.816e-56	214.0	COG1807@1|root,COG1807@2|Bacteria,2IZ8J@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase family 39	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,PMT_2
HFD3_k127_5684117_1	1123023.JIAI01000002_gene4878	2.798e-107	361.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,4DYNQ@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the UbiD family	-	-	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_5684117_4	1500301.JQMF01000026_gene2971	2.324e-14	84.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,4BBDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_5684117_0	1231391.AMZF01000066_gene1897	2.759e-229	721.0	COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,2VJ76@28216|Betaproteobacteria,3T20P@506|Alcaligenaceae	28216|Betaproteobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	2.7.7.58,6.3.2.14	ko:K02363	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5684117_2	1231391.AMZF01000066_gene1896	1.471e-100	333.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2VQ0N@28216|Betaproteobacteria,3T4IT@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HFD3_k127_5684117_3	1230476.C207_01213	3.997e-29	129.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_5693373_3	1304885.AUEY01000001_gene3156	9.032e-40	153.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD3_k127_5693373_7	243232.MJ_0531	1.92e-15	82.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23QW3@183939|Methanococci	183939|Methanococci	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_5693373_1	710696.Intca_3132	5.042e-109	371.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	caiC	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5693373_5	398767.Glov_3532	2.035e-31	130.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	DsbA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HFD3_k127_5693373_6	1449063.JMLS01000027_gene61	1.811e-18	97.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5693373_2	189753.AXAS01000041_gene2534	7.053e-72	255.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5693373_0	706587.Desti_2245	3.658e-141	466.0	COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,42NP6@68525|delta/epsilon subdivisions,2WIZK@28221|Deltaproteobacteria,2MSKP@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	2.7.7.58,6.3.2.14	ko:K02363	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5693373_4	1380394.JADL01000017_gene521	1.846e-36	143.0	COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,2UQVT@28211|Alphaproteobacteria,2JW8F@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HFD3_k127_5696390_1	521011.Mpal_2401	1.005e-88	314.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_5696390_4	1125973.JNLC01000011_gene580	1.207e-52	198.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_5696390_2	1280944.HY17_09980	2.514e-67	250.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TR1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_5696390_0	443152.MDG893_15387	1.406e-133	442.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RQPW@1236|Gammaproteobacteria,469ZW@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HFD3_k127_5696390_5	443152.MDG893_15467	1.367e-52	198.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5696390_7	1144310.PMI07_005447	4.467e-48	186.0	COG3181@1|root,COG3181@2|Bacteria,1N8DG@1224|Proteobacteria,2VFU9@28211|Alphaproteobacteria,4BNCX@82115|Rhizobiaceae	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5696390_6	443152.MDG893_15085	3.895e-50	191.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5696390_3	270374.MELB17_04807	2.059e-62	232.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,4640M@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_5696390_9	1382306.JNIM01000001_gene261	6.231e-45	177.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_5696390_8	1437448.AZRT01000129_gene253	7.788e-48	180.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5696710_4	1267535.KB906767_gene3267	1.661e-134	435.0	COG2239@1|root,COG2239@2|Bacteria,3Y7A9@57723|Acidobacteria	57723|Acidobacteria	P	Divalent cation transporter	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
HFD3_k127_5696710_9	867903.ThesuDRAFT_01092	8.269e-84	296.0	COG0277@1|root,COG0277@2|Bacteria,1V135@1239|Firmicutes,24BZN@186801|Clostridia	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD3_k127_5696710_11	880072.Desac_2266	2.221e-68	247.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,43BM7@68525|delta/epsilon subdivisions,2X6ZD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD3_k127_5696710_14	667014.Thein_0032	4.258e-28	123.0	COG1579@1|root,COG1579@2|Bacteria,2GH3N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HFD3_k127_5696710_12	644966.Tmar_2073	2.581e-39	151.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
HFD3_k127_5696710_13	448385.sce1656	1.636e-32	132.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2YYCH@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD3_k127_5696710_16	1278073.MYSTI_06203	1.148e-10	67.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,STAS,STAS_2
HFD3_k127_5696710_10	926569.ANT_23310	2.504e-80	277.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD3_k127_5696710_17	330214.NIDE0754	5.531e-10	64.0	2DT1T@1|root,33IAD@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	FtsL
HFD3_k127_5696710_1	1232410.KI421421_gene3858	4.618e-174	567.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PASTA domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HFD3_k127_5696710_3	269799.Gmet_0407	3.949e-139	460.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,43T9W@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD3_k127_5696710_8	404380.Gbem_0487	3.517e-101	346.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,43TX6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD3_k127_5696710_2	1121918.ARWE01000001_gene870	7.79e-146	470.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,43S7M@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
HFD3_k127_5696710_5	398767.Glov_0672	1.599e-120	401.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
HFD3_k127_5696710_6	1121918.ARWE01000001_gene872	3.765e-102	344.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,43TAE@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD3_k127_5696710_7	443143.GM18_3887	5.175e-102	346.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,43UB0@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD3_k127_5696710_0	1232410.KI421421_gene3865	2.699e-174	560.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43T1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	UDP-N-acetylmuramate-L-alanine ligase activity	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD3_k127_5696710_15	555088.DealDRAFT_1345	1.293e-27	118.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,42JQC@68298|Syntrophomonadaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD3_k127_5703400_9	247490.KSU1_C0207	0.0005303	44.0	COG4974@1|root,COG4974@2|Bacteria,2J296@203682|Planctomycetes	203682|Planctomycetes	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD3_k127_5703400_3	502025.Hoch_4707	8.925e-61	221.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,434HT@68525|delta/epsilon subdivisions,2WYV2@28221|Deltaproteobacteria,2Z0PY@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_5703400_5	1131269.AQVV01000016_gene1868	4.041e-38	148.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	2.7.7.80,2.8.1.11,3.13.1.6	ko:K21140,ko:K21147	ko04122,map04122	-	R07459,R07461,R11524	RC00043,RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,Rhodanese,ThiF
HFD3_k127_5703400_7	1144275.COCOR_03228	1.634e-18	94.0	COG0741@1|root,COG0741@2|Bacteria,1N1GB@1224|Proteobacteria,42X1K@68525|delta/epsilon subdivisions,2WTCI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HFD3_k127_5703400_0	76114.p2A133	8.73e-251	783.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W317@28216|Betaproteobacteria	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_5703400_1	1131269.AQVV01000028_gene28	8.667e-122	431.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HFD3_k127_5703400_2	237368.SCABRO_00411	5.581e-78	270.0	COG0345@1|root,COG0345@2|Bacteria,2IY5U@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HFD3_k127_5703400_8	994573.T472_0218430	7.5e-12	73.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,24MJ1@186801|Clostridia,36UIM@31979|Clostridiaceae	186801|Clostridia	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Big_2,CW_binding_1,Cu_amine_oxidN1,DUF3298,Polysacc_deac_1,SH3_3
HFD3_k127_5703400_4	1232410.KI421419_gene2520	1.382e-42	162.0	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,42TUM@68525|delta/epsilon subdivisions,2WQJJ@28221|Deltaproteobacteria,43V1R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
HFD3_k127_5703400_6	1232410.KI421426_gene1392	7.768e-26	112.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,42U7P@68525|delta/epsilon subdivisions,2WQKY@28221|Deltaproteobacteria,43TBQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5718339_4	1173022.Cri9333_1541	1.279e-31	138.0	COG4447@1|root,COG4447@2|Bacteria,1GAGV@1117|Cyanobacteria,1HF4J@1150|Oscillatoriales	1117|Cyanobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HFD3_k127_5718339_3	1056816.JAFQ01000004_gene3594	1.56e-41	166.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FUBJ@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD3_k127_5718339_2	1297863.APJF01000008_gene584	1.57e-55	202.0	COG0625@1|root,COG0625@2|Bacteria,1N2Z1@1224|Proteobacteria,2U0AX@28211|Alphaproteobacteria,3JQT5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N,GST_N_3
HFD3_k127_5718339_1	265072.Mfla_0195	2.435e-71	251.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,2KKVS@206350|Nitrosomonadales	206350|Nitrosomonadales	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HFD3_k127_5718339_0	756067.MicvaDRAFT_2506	3.164e-247	781.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H9T8@1150|Oscillatoriales	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
HFD3_k127_5721325_1	867903.ThesuDRAFT_01213	4.021e-186	591.0	COG0114@1|root,COG0114@2|Bacteria,1UHPH@1239|Firmicutes,25F3I@186801|Clostridia,3WCCI@538999|Clostridiales incertae sedis	186801|Clostridia	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD3_k127_5721325_2	330214.NIDE0494	1.875e-88	297.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
HFD3_k127_5721325_3	1210908.HSB1_24940	5.916e-10	70.0	COG0697@1|root,arCOG00272@2157|Archaea,2XVSM@28890|Euryarchaeota,23S7J@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_5721325_0	1183438.GKIL_3640	3.976e-307	965.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1GBPU@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HFD3_k127_5760263_4	868595.Desca_1044	1.686e-59	214.0	COG2215@1|root,COG2215@2|Bacteria,1VA77@1239|Firmicutes	1239|Firmicutes	S	PFAM Nickel cobalt transporter, high-affinity	ureH	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
HFD3_k127_5760263_8	479434.Sthe_0748	4.237e-40	153.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi,27Y6P@189775|Thermomicrobia	189775|Thermomicrobia	H	MoaE protein	-	-	2.8.1.12	ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HFD3_k127_5760263_5	330214.NIDE2773	2.157e-55	198.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HFD3_k127_5760263_1	1134413.ANNK01000087_gene236	3.262e-92	314.0	2A6Y1@1|root,30VSZ@2|Bacteria,1UBKQ@1239|Firmicutes,4IN0U@91061|Bacilli,1ZMG5@1386|Bacillus	91061|Bacilli	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_5760263_14	1236959.BAMT01000006_gene404	0.0005125	48.0	2E3UK@1|root,32YRY@2|Bacteria,1N74J@1224|Proteobacteria,2VVQ2@28216|Betaproteobacteria,2KN10@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HFD3_k127_5760263_13	483219.LILAB_31245	7.714e-05	53.0	COG5662@1|root,COG5662@2|Bacteria,1Q8RV@1224|Proteobacteria,43448@68525|delta/epsilon subdivisions,2X557@28221|Deltaproteobacteria,2Z04T@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_5760263_9	671143.DAMO_2841	8.776e-27	117.0	COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_5760263_7	1122180.Lokhon_02530	5.644e-41	161.0	COG2085@1|root,COG2085@2|Bacteria,1MXS0@1224|Proteobacteria,2TS1W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NADPH-dependent f420 reductase	npdG	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD3_k127_5760263_3	309801.trd_A0548	5.543e-68	239.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi,27XFS@189775|Thermomicrobia	189775|Thermomicrobia	S	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HFD3_k127_5760263_11	1380390.JIAT01000010_gene3612	8.466e-22	104.0	COG1920@1|root,COG1920@2|Bacteria,2HNVD@201174|Actinobacteria,4CQ43@84995|Rubrobacteria	84995|Rubrobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HFD3_k127_5760263_2	326427.Cagg_0665	3.916e-88	301.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,376XW@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM LPPG domain	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HFD3_k127_5760263_0	309801.trd_A0900	3.759e-132	436.0	COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi,27YSR@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HFD3_k127_5760263_6	216594.MMAR_2798	8.49e-52	199.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,23625@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_5760263_10	1449044.JMLE01000018_gene1661	6.537e-23	111.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5760263_12	272123.Anacy_4405	2.104e-21	96.0	COG0834@1|root,COG0834@2|Bacteria,1G36J@1117|Cyanobacteria,1HMZA@1161|Nostocales	1117|Cyanobacteria	ET	Amino acid ABC transporter substrate-binding protein, PAAT family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	Ion_trans_2,Lig_chan,SBP_bac_3
HFD3_k127_5774441_8	644282.Deba_0317	3.533e-40	160.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HFD3_k127_5774441_3	1382306.JNIM01000001_gene587	5.19e-107	356.0	COG1237@1|root,COG1237@2|Bacteria,2G73K@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD3_k127_5774441_11	479432.Sros_0264	3.896e-27	113.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD3_k127_5774441_15	44060.JODL01000038_gene499	2.633e-12	70.0	COG4274@1|root,COG4274@2|Bacteria,2IN0N@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD3_k127_5774441_0	269799.Gmet_0071	5.145e-227	737.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HFD3_k127_5774441_7	269799.Gmet_2567	2.594e-84	286.0	COG1043@1|root,COG1043@2|Bacteria,1R8TC@1224|Proteobacteria,42MH4@68525|delta/epsilon subdivisions,2WJYN@28221|Deltaproteobacteria,43SC1@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA-2	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_2567	Acetyltransf_11,Hexapep
HFD3_k127_5774441_13	443152.MDG893_01335	2.446e-18	87.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,468WS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HFD3_k127_5774441_4	443152.MDG893_15065	2.665e-105	351.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,1RQG7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	phtD	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_5774441_12	1122915.AUGY01000118_gene6541	1.692e-24	116.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5774441_2	1232410.KI421412_gene157	1.935e-178	569.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HFD3_k127_5774441_18	880073.Calab_2414	0.0008021	51.0	2915M@1|root,2ZNSW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5774441_17	1408445.JHXP01000001_gene1503	2.578e-05	47.0	COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,1RQYT@1236|Gammaproteobacteria,1JDY5@118969|Legionellales	118969|Legionellales	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HFD3_k127_5774441_10	1089552.KI911559_gene3261	1.095e-31	145.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2JQWJ@204441|Rhodospirillales	204441|Rhodospirillales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD3_k127_5774441_6	335543.Sfum_0758	2.463e-101	352.0	COG4775@1|root,COG4775@2|Bacteria,1QX52@1224|Proteobacteria,43CEZ@68525|delta/epsilon subdivisions,2X7PY@28221|Deltaproteobacteria,2MRBQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD3_k127_5774441_9	644966.Tmar_0257	4.986e-40	153.0	COG1622@1|root,COG1622@2|Bacteria,1TPMD@1239|Firmicutes	1239|Firmicutes	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	cbaB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HFD3_k127_5774441_1	926550.CLDAP_28410	3.165e-199	637.0	COG0843@1|root,COG0843@2|Bacteria,2G628@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD3_k127_5774441_16	65393.PCC7424_1974	1.911e-08	67.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,3KI0K@43988|Cyanothece	1117|Cyanobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_5774441_5	1185876.BN8_02171	6.025e-104	350.0	28PTG@1|root,2ZCEQ@2|Bacteria,4NWVQ@976|Bacteroidetes,47W24@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5780604_9	1120949.KB903314_gene303	4.504e-22	110.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5780604_4	1120949.KB903314_gene302	3.441e-110	377.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1,SBP_bac_6
HFD3_k127_5780604_0	247490.KSU1_C1370	2.78e-243	767.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD3_k127_5780604_14	62928.azo3667	3.606e-13	74.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,2KX05@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HFD3_k127_5780604_1	314278.NB231_10523	6.627e-175	555.0	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
HFD3_k127_5780604_8	1123236.KB899376_gene737	3.698e-32	128.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,467S6@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
HFD3_k127_5780604_11	596151.DesfrDRAFT_4089	3.421e-16	88.0	2DT2S@1|root,33IFM@2|Bacteria,1NJZN@1224|Proteobacteria,436Z5@68525|delta/epsilon subdivisions,2X1PN@28221|Deltaproteobacteria,2MFF7@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5780604_6	1123008.KB905716_gene3645	1.62e-45	175.0	COG0428@1|root,COG0428@2|Bacteria,4NT7J@976|Bacteroidetes,2FWBB@200643|Bacteroidia,22ZZK@171551|Porphyromonadaceae	976|Bacteroidetes	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	Zip
HFD3_k127_5780604_12	1500894.JQNN01000001_gene4088	1.124e-15	82.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,2VYCS@28216|Betaproteobacteria,4758E@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5780604_5	1185652.USDA257_c56260	2.95e-71	248.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,2U3GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HFD3_k127_5780604_7	383372.Rcas_3774	1.303e-39	158.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,377HX@32061|Chloroflexia	32061|Chloroflexia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_5780604_2	357804.Ping_1819	1.418e-159	515.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD3_k127_5780604_13	1528106.JRJE01000001_gene2154	9.435e-14	75.0	COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,2UE4Y@28211|Alphaproteobacteria,2JTCI@204441|Rhodospirillales	204441|Rhodospirillales	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5780604_10	1122135.KB893146_gene1531	5.493e-18	87.0	COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,2UE4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5780604_3	251229.Chro_2746	5.32e-116	379.0	COG0668@1|root,COG0668@2|Bacteria,1GHVY@1117|Cyanobacteria,3VN2Q@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
HFD3_k127_5804078_1	1123501.KB902290_gene1571	2.14e-159	524.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_5804078_3	1123501.KB902290_gene1570	6.443e-43	171.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_5804078_2	1100720.ALKN01000052_gene507	5.595e-54	206.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_5804078_0	472759.Nhal_0042	5.547e-238	746.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HFD3_k127_5805520_17	1321781.HMPREF1985_00941	5.683e-20	93.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4H4QY@909932|Negativicutes	909932|Negativicutes	G	Belongs to the phosphoglycerate mutase family	cobC	-	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HFD3_k127_5805520_7	589865.DaAHT2_1947	2.57e-78	286.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HFD3_k127_5805520_1	269799.Gmet_0918	1.173e-168	537.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,43SBN@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD3_k127_5805520_12	1304885.AUEY01000039_gene1535	1.069e-47	182.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MJMG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD3_k127_5805520_19	397945.Aave_0296	0.0002177	51.0	COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,4ADKP@80864|Comamonadaceae	28216|Betaproteobacteria	M	shape-determining protein	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD3_k127_5805520_2	1125863.JAFN01000001_gene2977	3.385e-168	548.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
HFD3_k127_5805520_6	56780.SYN_00550	2.209e-110	368.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2MQBR@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD3_k127_5805520_11	533240.CRC_01116	4.399e-65	243.0	COG0745@1|root,COG2199@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1G027@1117|Cyanobacteria,1HKPC@1161|Nostocales	1117|Cyanobacteria	T	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,Trans_reg_C
HFD3_k127_5805520_16	177437.HRM2_40310	1.873e-24	108.0	COG2204@1|root,COG2204@2|Bacteria,1RHEG@1224|Proteobacteria,42T1C@68525|delta/epsilon subdivisions,2WP30@28221|Deltaproteobacteria,2MK48@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_5805520_5	876269.ARWA01000001_gene2144	3.892e-113	376.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,3N9KG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
HFD3_k127_5805520_3	671143.DAMO_1298	3.627e-149	484.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_5805520_8	1386089.N865_04190	6.089e-77	267.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,2GNPX@201174|Actinobacteria,4FFVN@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	osaB	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_5805520_13	335543.Sfum_1708	5.685e-40	154.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MS32@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HFD3_k127_5805520_4	338963.Pcar_0200	1.824e-113	383.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,43RYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD3_k127_5805520_9	401053.AciPR4_1066	7.447e-71	244.0	COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia	204432|Acidobacteriia	H	TIGRFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HFD3_k127_5805520_10	671143.DAMO_0003	9.661e-66	234.0	COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HFD3_k127_5805520_15	1307761.L21SP2_1117	1.319e-30	129.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD3_k127_5805520_18	234267.Acid_0471	7.177e-08	59.0	COG1193@1|root,COG1193@2|Bacteria,3Y8PZ@57723|Acidobacteria	57723|Acidobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HFD3_k127_5805520_14	1232410.KI421420_gene3159	1.969e-38	149.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria,43UXP@69541|Desulfuromonadales	28221|Deltaproteobacteria	MU	Signal peptidase (SPase) II	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD3_k127_5805520_0	1123508.JH636439_gene1811	0.0	1214.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD3_k127_5820802_1	1380358.JADJ01000013_gene3430	1.983e-10	63.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Usp
HFD3_k127_5820802_3	243231.GSU2771	7.066e-05	46.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42Z3J@68525|delta/epsilon subdivisions,2WUA5@28221|Deltaproteobacteria,43TCS@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HFD3_k127_5820802_2	1262914.BN533_00448	3.843e-09	69.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4H3E3@909932|Negativicutes	909932|Negativicutes	P	NMT1 THI5-like protein	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_5820802_0	1173263.Syn7502_03004	4.466e-21	105.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_58314_0	941449.dsx2_1642	2.786e-181	582.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,43D2A@68525|delta/epsilon subdivisions,2WJNX@28221|Deltaproteobacteria,2MA4Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
HFD3_k127_58314_2	595494.Tola_1585	2.077e-74	263.0	arCOG09463@1|root,2Z8U6@2|Bacteria,1NHE7@1224|Proteobacteria,1RY5W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA sulfur modification protein DndB	-	-	-	ko:K19169	-	-	-	-	ko00000,ko02048	-	-	-	DndB
HFD3_k127_58314_3	1449069.JMLO01000010_gene415	0.0001919	44.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria,4G2Q6@85025|Nocardiaceae	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD3_k127_58314_1	485913.Krac_12226	1.447e-91	317.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_5841215_16	1232410.KI421413_gene692	1.14e-43	164.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,43UBD@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HFD3_k127_5841215_8	1122947.FR7_3310	3.556e-82	280.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_5841215_21	1278073.MYSTI_05227	8.825e-26	108.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD3_k127_5841215_15	404380.Gbem_3103	3.577e-47	174.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2WP1V@28221|Deltaproteobacteria,43UNK@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1604	LacAB_rpiB
HFD3_k127_5841215_2	243231.GSU1607	9.797e-198	623.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,43U6J@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD3_k127_5841215_11	398767.Glov_1748	1.288e-61	216.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD3_k127_5841215_4	1242864.D187_004612	1.366e-103	349.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2YUVJ@29|Myxococcales	28221|Deltaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1624	RibD_C,dCMP_cyt_deam_1
HFD3_k127_5841215_13	443143.GM18_3010	5.976e-57	205.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,43UI4@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HFD3_k127_5841215_3	56780.SYN_02371	3.575e-145	471.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD3_k127_5841215_12	1123325.JHUV01000002_gene125	4.289e-57	203.0	COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae	200783|Aquificae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD3_k127_5841215_20	483219.LILAB_31755	2.621e-34	137.0	COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2YVKR@29|Myxococcales	28221|Deltaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD3_k127_5841215_0	1232410.KI421413_gene803	0.0	1126.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,43RYY@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Leucyl-tRNA synthetase, Domain 2	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HFD3_k127_5841215_22	1232410.KI421413_gene802	1.184e-15	85.0	COG2980@1|root,COG2980@2|Bacteria,1NIUQ@1224|Proteobacteria,42XGJ@68525|delta/epsilon subdivisions,2WSS7@28221|Deltaproteobacteria,43V49@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Lipopolysaccharide-assembly	lptE	-	-	-	-	-	-	-	-	-	-	-	LptE
HFD3_k127_5841215_23	411464.DESPIG_00631	8.499e-07	57.0	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria,2MD9B@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD3_k127_5841215_14	555779.Dthio_PD2456	2.711e-56	205.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2M9RT@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD3_k127_5841215_1	861299.J421_3613	1.37e-304	947.0	COG3808@1|root,COG3808@2|Bacteria,1ZT09@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD3_k127_5841215_25	1042209.HK44_009355	0.0004455	46.0	2B41E@1|root,31WRS@2|Bacteria,1P8VA@1224|Proteobacteria,1S1WR@1236|Gammaproteobacteria,1YQ7R@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5841215_24	1205680.CAKO01000040_gene803	1.335e-06	53.0	2B41E@1|root,31WRS@2|Bacteria,1P8VA@1224|Proteobacteria,2TT81@28211|Alphaproteobacteria,2JX93@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5841215_17	886293.Sinac_0387	1.171e-40	162.0	28JIP@1|root,2Z82C@2|Bacteria	2|Bacteria	S	s1 p1 nuclease	-	-	3.1.30.1	ko:K05986	-	-	-	-	ko00000,ko01000	-	-	-	S1-P1_nuclease
HFD3_k127_5841215_18	330214.NIDE3683	2.261e-37	144.0	2CNK3@1|root,32SH9@2|Bacteria	2|Bacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
HFD3_k127_5841215_6	469383.Cwoe_4099	1.382e-86	297.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_5841215_19	671065.MetMK1DRAFT_00016440	7e-35	142.0	COG3396@1|root,arCOG04786@2157|Archaea	2157|Archaea	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD3_k127_5841215_10	471852.Tcur_3575	2.329e-67	238.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4EFT7@85012|Streptosporangiales	201174|Actinobacteria	C	Electron transfer flavoprotein domain	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD3_k127_5841215_7	1382306.JNIM01000001_gene2733	6.458e-84	288.0	COG2025@1|root,COG2025@2|Bacteria,2G6PP@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD3_k127_5841215_9	189753.AXAS01000041_gene2534	5.078e-81	281.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5841215_5	189753.AXAS01000041_gene2534	5.566e-92	310.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_5868009_1	1123023.JIAI01000002_gene5491	8.197e-125	417.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
HFD3_k127_5868009_4	930169.B5T_02854	2.339e-78	271.0	COG1028@1|root,COG1028@2|Bacteria,1N3A2@1224|Proteobacteria,1RQRI@1236|Gammaproteobacteria,1XN1X@135619|Oceanospirillales	135619|Oceanospirillales	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_5868009_0	882082.SaccyDRAFT_3032	1.191e-168	552.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4DY4S@85010|Pseudonocardiales	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_5868009_3	1121334.KB911071_gene2052	7.225e-91	320.0	COG0146@1|root,COG0146@2|Bacteria,1U1N7@1239|Firmicutes,24D6C@186801|Clostridia,3WPJW@541000|Ruminococcaceae	186801|Clostridia	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_5868009_5	278957.ABEA03000160_gene8	9.136e-19	91.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD3_k127_5868009_2	631454.N177_1444	1.045e-110	369.0	COG2079@1|root,COG2079@2|Bacteria,1PJXP@1224|Proteobacteria,2V951@28211|Alphaproteobacteria,1JQ0Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_5868137_3	1449347.JQLN01000004_gene6490	4.458e-27	113.0	COG1021@1|root,COG1021@2|Bacteria,2I2IR@201174|Actinobacteria,2M42P@2063|Kitasatospora	201174|Actinobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	2.7.7.58,6.3.2.14	ko:K02363	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C
HFD3_k127_5868137_5	768710.DesyoDRAFT_4908	2.676e-08	57.0	COG1943@1|root,COG1943@2|Bacteria,1V6R5@1239|Firmicutes,25DIV@186801|Clostridia	186801|Clostridia	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HFD3_k127_5868137_0	443152.MDG893_15075	1.234e-56	212.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5868137_1	443152.MDG893_15467	1.434e-55	209.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5868137_4	1206729.BAFZ01000054_gene3073	1.983e-11	76.0	COG0715@1|root,COG0715@2|Bacteria,2GNMC@201174|Actinobacteria,4FZTS@85025|Nocardiaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_5869642_3	234267.Acid_7161	3.509e-29	123.0	COG2159@1|root,COG2159@2|Bacteria,3Y5M2@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Amidohydrolase 2	-	-	4.1.1.45	ko:K03392,ko:K07045	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_5869642_0	204669.Acid345_2367	3.319e-123	404.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD3_k127_5869642_1	368408.Tpen_1165	8.817e-68	238.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPUC@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ABC transporter related	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
HFD3_k127_5869642_2	555079.Toce_2182	1.212e-31	135.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24AHX@186801|Clostridia,42FZR@68295|Thermoanaerobacterales	186801|Clostridia	S	Zn-dependent hydrolases of the	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_5869642_4	1131266.ARWQ01000002_gene637	0.0001187	55.0	COG0457@1|root,arCOG03038@2157|Archaea,41SRQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HFD3_k127_58764_2	96561.Dole_2675	7.577e-43	166.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MHV7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD3_k127_58764_3	1499967.BAYZ01000095_gene4122	1.468e-32	143.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_58764_0	384765.SIAM614_07183	4.455e-49	185.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	MA20_07390	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD3_k127_5878034_8	598467.BrE312_1285	3.624e-14	83.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,1SF34@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,TAT_signal
HFD3_k127_5878034_5	469383.Cwoe_4081	5.869e-87	298.0	COG1071@1|root,COG1071@2|Bacteria,2IC03@201174|Actinobacteria,4CQ7Q@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM dehydrogenase, E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HFD3_k127_5878034_4	469383.Cwoe_4080	2.393e-106	353.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	2|Bacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
HFD3_k127_5878034_3	469383.Cwoe_4083	4.647e-112	374.0	COG1071@1|root,COG1071@2|Bacteria,2HVS4@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD3_k127_5878034_2	469383.Cwoe_4082	2.237e-116	383.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CRBS@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD3_k127_5878034_1	1501230.ET33_19345	8.932e-121	394.0	COG0667@1|root,COG0667@2|Bacteria,1V300@1239|Firmicutes,4HERM@91061|Bacilli,26TBI@186822|Paenibacillaceae	91061|Bacilli	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_5878034_6	1202768.JROF01000013_gene891	1.307e-15	88.0	COG0697@1|root,arCOG00272@2157|Archaea,2XUHA@28890|Euryarchaeota,23UY1@183963|Halobacteria	183963|Halobacteria	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_5878034_7	743719.PaelaDRAFT_0962	5.758e-15	88.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5878034_0	1231391.AMZF01000094_gene122	1.88e-179	579.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_5887477_5	357808.RoseRS_0308	9.006e-19	88.0	COG3824@1|root,COG3824@2|Bacteria,2G72E@200795|Chloroflexi,377H1@32061|Chloroflexia	32061|Chloroflexia	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HFD3_k127_5887477_6	1254432.SCE1572_44680	1.43e-05	51.0	COG2253@1|root,COG2253@2|Bacteria,1NQ5D@1224|Proteobacteria,42UBR@68525|delta/epsilon subdivisions,2WTDZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HFD3_k127_5887477_1	1178482.BJB45_20225	6.362e-110	364.0	COG3291@1|root,COG3291@2|Bacteria,1NE5Q@1224|Proteobacteria	1224|Proteobacteria	O	Pregnancy-associated plasma protein-A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M43
HFD3_k127_5887477_4	1173024.KI912151_gene2020	6.593e-19	89.0	2E8HZ@1|root,332W1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5887477_2	1380394.JADL01000004_gene6131	3.168e-106	355.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TU4F@28211|Alphaproteobacteria,2JV7T@204441|Rhodospirillales	204441|Rhodospirillales	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
HFD3_k127_5887477_0	671143.DAMO_3037	1.803e-255	797.0	COG0129@1|root,COG0129@2|Bacteria,2NNSM@2323|unclassified Bacteria	2|Bacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD3_k127_5887477_3	1173263.Syn7502_03004	4.239e-37	152.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5901038_3	1366050.N234_08085	4.237e-40	153.0	COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,2VVWU@28216|Betaproteobacteria,1K571@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HFD3_k127_5901038_6	935840.JAEQ01000004_gene646	1.887e-17	94.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5901038_0	443143.GM18_0728	3.695e-294	910.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HFD3_k127_5901038_1	378806.STAUR_0942	3.203e-118	389.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_5901038_5	555088.DealDRAFT_2912	2.422e-20	96.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,42JZB@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HFD3_k127_5901038_9	751945.Theos_1638	3.188e-06	52.0	2A200@1|root,30Q9V@2|Bacteria,1WN7Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5901038_7	667014.Thein_1278	2.27e-17	85.0	2BHIW@1|root,32BMB@2|Bacteria,2GI5M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HFD3_k127_5901038_4	667014.Thein_1277	8.708e-26	108.0	2E3EN@1|root,30IAQ@2|Bacteria,2GI5U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HFD3_k127_5901038_2	1125863.JAFN01000001_gene1218	1.18e-57	211.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_5920945_6	751944.HALDL1_10460	1.375e-47	183.0	COG2141@1|root,arCOG02410@2157|Archaea,2XU72@28890|Euryarchaeota,23S3D@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	mer2	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_5920945_2	1120983.KB894572_gene3272	6.632e-95	324.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,1JQ4A@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_5920945_7	935840.JAEQ01000009_gene1334	2.159e-42	173.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,43JPS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_5920945_0	1532558.JL39_24305	1.143e-206	662.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_5920945_9	1298920.KI911353_gene4912	7.185e-14	84.0	2DEXP@1|root,2ZPPM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5920945_5	935840.JAEQ01000004_gene643	6.269e-48	186.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepQ	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_5920945_1	935840.JAEQ01000004_gene642	1.788e-196	627.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,43I9H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_5920945_10	743719.PaelaDRAFT_0962	3.324e-13	81.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26UYR@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5920945_8	690585.JNNU01000008_gene3736	1.764e-31	136.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5920945_4	1380391.JIAS01000004_gene2950	4.368e-56	209.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JVH6@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
HFD3_k127_5920945_3	234267.Acid_5023	1.24e-88	307.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_5943184_13	933262.AXAM01000021_gene463	3.667e-09	59.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42P6W@68525|delta/epsilon subdivisions,2WIWM@28221|Deltaproteobacteria,2MPYD@213118|Desulfobacterales	28221|Deltaproteobacteria	V	N-6 DNA Methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HFD3_k127_5943184_7	485913.Krac_8169	1.41e-45	178.0	COG0111@1|root,COG0111@2|Bacteria,2G6KY@200795|Chloroflexi	200795|Chloroflexi	C	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_5943184_12	1532558.JL39_24335	4.803e-21	105.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_5943184_6	1231391.AMZF01000008_gene1529	3.87e-47	185.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_5943184_10	1532558.JL39_00915	2.321e-25	120.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_5943184_3	1134413.ANNK01000087_gene253	1.854e-160	518.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,1ZR0K@1386|Bacillus	91061|Bacilli	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_5943184_0	1356854.N007_12900	2.506e-206	647.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,4HAWA@91061|Bacilli	91061|Bacilli	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase
HFD3_k127_5943184_4	1356854.N007_12895	9.314e-60	211.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,4HFTY@91061|Bacilli	91061|Bacilli	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase_C
HFD3_k127_5943184_2	1356854.N007_12890	7.934e-174	550.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HD58@91061|Bacilli	91061|Bacilli	E	Ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_5943184_5	1356854.N007_12915	4.674e-59	209.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes	1239|Firmicutes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase_C
HFD3_k127_5943184_1	1298920.KI911353_gene4911	4.566e-185	586.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,21ZCQ@1506553|Lachnoclostridium	1239|Firmicutes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	hacA	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HFD3_k127_5943184_11	877455.Metbo_1449	7.406e-23	101.0	COG1741@1|root,arCOG02935@2157|Archaea,2XU8Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HFD3_k127_597513_2	1123501.KB902290_gene1570	9.006e-47	182.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_597513_0	575540.Isop_1153	2.204e-62	228.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
HFD3_k127_597513_4	1380356.JNIK01000003_gene1302	3.107e-15	87.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EU6Y@85013|Frankiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_597513_3	935840.JAEQ01000004_gene646	3.056e-16	90.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_597513_1	1123060.JONP01000001_gene1641	8.527e-57	209.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria,2JUQX@204441|Rhodospirillales	204441|Rhodospirillales	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD3_k127_597513_5	1123511.KB905858_gene3854	2.02e-11	75.0	COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,4H3XZ@909932|Negativicutes	909932|Negativicutes	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_6043175_4	443143.GM18_0639	1.054e-40	154.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,43RZH@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD3_k127_6043175_2	373903.Hore_01680	1.586e-99	336.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WADU@53433|Halanaerobiales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD3_k127_6043175_6	515635.Dtur_0256	5.898e-35	139.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria	2|Bacteria	J	methionyl-tRNA aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HFD3_k127_6043175_3	1123371.ATXH01000018_gene1391	1.21e-45	171.0	COG2078@1|root,COG2078@2|Bacteria,2GH4V@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HFD3_k127_6043175_7	264732.Moth_0731	1.699e-32	139.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24AHX@186801|Clostridia,42FZR@68295|Thermoanaerobacterales	186801|Clostridia	S	Zn-dependent hydrolases of the	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_6043175_5	644282.Deba_0456	4.083e-40	152.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD3_k127_6043175_1	1410653.JHVC01000005_gene2560	4.836e-102	339.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD3_k127_6043175_0	1121440.AUMA01000011_gene2309	1.43e-322	1007.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD3_k127_6086556_4	1267005.KB911255_gene2387	2.635e-08	55.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD3_k127_6086556_3	1262914.BN533_01826	9.787e-22	108.0	COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes	1239|Firmicutes	P	Abc transporter	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_6086556_1	1042326.AZNV01000012_gene1943	2.604e-97	340.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,4BAT1@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_6086556_2	593117.TGAM_1014	3.307e-90	309.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM ABC transporter	-	-	3.6.3.29,3.6.3.30	ko:K02010,ko:K02017,ko:K02062,ko:K10112,ko:K10199,ko:K17314	ko02010,map02010	M00189,M00190,M00191,M00194,M00196,M00197,M00200,M00201,M00203,M00206,M00207,M00491,M00602,M00604,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.13,3.A.1.1.14,3.A.1.1.15,3.A.1.10,3.A.1.19,3.A.1.8	-	-	ABC_tran,TOBE_2
HFD3_k127_6086556_0	1187851.A33M_3000	1.401e-119	392.0	COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,3FCKK@34008|Rhodovulum	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
HFD3_k127_61111_0	398512.JQKC01000033_gene5010	0.0	1951.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WHE2@541000|Ruminococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HFD3_k127_61111_1	1278073.MYSTI_00213	1.964e-39	152.0	COG1522@1|root,COG1522@2|Bacteria,1N0DP@1224|Proteobacteria,42W6I@68525|delta/epsilon subdivisions,2WSF8@28221|Deltaproteobacteria,2YW31@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HFD3_k127_61111_2	713587.THITH_07545	2.34e-25	106.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,1X24R@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD3_k127_611415_3	243233.MCA2877	1.184e-24	103.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,1RSA3@1236|Gammaproteobacteria,1XEB5@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HFD3_k127_611415_2	671065.MetMK1DRAFT_00016440	8.933e-36	146.0	COG3396@1|root,arCOG04786@2157|Archaea	2157|Archaea	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD3_k127_611415_4	59374.Fisuc_1084	7.302e-15	86.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_611415_5	1537715.JQFJ01000002_gene1368	4.905e-11	70.0	COG3435@1|root,COG3435@2|Bacteria,1RFPN@1224|Proteobacteria	1224|Proteobacteria	Q	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_611415_0	452637.Oter_2162	1.635e-109	364.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HFD3_k127_611415_1	1267535.KB906767_gene3245	8.528e-104	347.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HFD3_k127_6130439_28	745014.OMB55_00012940	3.556e-08	57.0	COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,1S4BY@1236|Gammaproteobacteria,1J6XP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD3_k127_6130439_24	59374.Fisuc_1084	2.842e-14	84.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6130439_21	926561.KB900618_gene89	6.462e-17	94.0	COG0664@1|root,COG0664@2|Bacteria,1VD7I@1239|Firmicutes,25MZK@186801|Clostridia,3WBXH@53433|Halanaerobiales	186801|Clostridia	K	PFAM Bacterial regulatory proteins, crp family	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_6130439_3	246194.CHY_1210	5.854e-145	466.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
HFD3_k127_6130439_11	266117.Rxyl_1977	6.148e-72	252.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4CU1Q@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HFD3_k127_6130439_10	330214.NIDE2744	1.518e-84	290.0	COG0181@1|root,COG0181@2|Bacteria,3J0GC@40117|Nitrospirae	40117|Nitrospirae	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD3_k127_6130439_5	1232410.KI421412_gene411	1.383e-129	426.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,43SX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HFD3_k127_6130439_12	338963.Pcar_3065	8.844e-63	225.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43SCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HFD3_k127_6130439_1	1504672.669783770	6.803e-196	619.0	COG3391@1|root,COG3391@2|Bacteria,1MVXR@1224|Proteobacteria,2VJPF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	40-residue yvtn family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD3_k127_6130439_16	118163.Ple7327_2755	2.822e-36	144.0	COG3544@1|root,COG3544@2|Bacteria,1GAAR@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
HFD3_k127_6130439_22	1379858.N508_01222	2.558e-16	83.0	COG0666@1|root,COG0790@1|root,COG0666@2|Bacteria,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5,Peptidase_C14,Sel1
HFD3_k127_6130439_15	1040986.ATYO01000015_gene635	3.611e-38	149.0	COG0666@1|root,COG0666@2|Bacteria,1NC5F@1224|Proteobacteria,2UNCX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0666 FOG Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HFD3_k127_6130439_17	1173020.Cha6605_3180	4.556e-36	145.0	COG3791@1|root,COG3791@2|Bacteria,1G5S8@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD3_k127_6130439_19	195253.Syn6312_1001	9.833e-30	120.0	COG2929@1|root,COG2929@2|Bacteria,1G92M@1117|Cyanobacteria,1H22Y@1129|Synechococcus	1117|Cyanobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HFD3_k127_6130439_26	102129.Lepto7375DRAFT_1871	5.531e-12	71.0	2C6B2@1|root,335GA@2|Bacteria,1G9BT@1117|Cyanobacteria,1HDYH@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6130439_9	521011.Mpal_1141	1.345e-91	308.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	28890|Euryarchaeota	H	PFAM UBA THIF-type NAD FAD binding protein	ubaA	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD3_k127_6130439_2	247490.KSU1_D0389	4.881e-175	557.0	COG0498@1|root,COG0498@2|Bacteria,2IXWR@203682|Planctomycetes	203682|Planctomycetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD3_k127_6130439_18	314345.SPV1_14254	2.052e-31	125.0	COG1977@1|root,COG1977@2|Bacteria,1N4Z0@1224|Proteobacteria	1224|Proteobacteria	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD3_k127_6130439_7	1485545.JQLW01000007_gene794	1.138e-114	379.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	-	2.5.1.47,6.1.1.16	ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
HFD3_k127_6130439_27	1232437.KL662001_gene4561	5.2e-09	65.0	2D8IH@1|root,32TRC@2|Bacteria,1MZ42@1224|Proteobacteria,42UE6@68525|delta/epsilon subdivisions,2WPZW@28221|Deltaproteobacteria,2MKMY@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6130439_30	1121430.JMLG01000019_gene1643	0.0001659	51.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_6130439_14	497964.CfE428DRAFT_0896	3.443e-41	158.0	COG1595@1|root,COG1595@2|Bacteria,46V3R@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_6130439_23	1121918.ARWE01000001_gene2163	3.751e-16	91.0	2AKQ6@1|root,31BGX@2|Bacteria,1RCS3@1224|Proteobacteria,43CF4@68525|delta/epsilon subdivisions,2WP3G@28221|Deltaproteobacteria,43SKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4
HFD3_k127_6130439_29	936573.HMPREF1147_1547	3.13e-07	55.0	COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,4H5YN@909932|Negativicutes	909932|Negativicutes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	-	-	-	-	-	-	-	-	-	MttA_Hcf106
HFD3_k127_6130439_25	765913.ThidrDRAFT_2089	1.027e-13	81.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1WWP5@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD3_k127_6130439_0	1499967.BAYZ01000136_gene58	8.523e-198	627.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
HFD3_k127_6130439_4	671143.DAMO_0706	2.293e-132	435.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HFD3_k127_6130439_13	986075.CathTA2_3037	3.077e-46	171.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD3_k127_6130439_6	871963.Desdi_2783	9.461e-128	418.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,261AX@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD3_k127_6130439_8	156889.Mmc1_3712	1.53e-112	369.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD3_k127_6130439_20	379066.GAU_3530	3.621e-22	96.0	COG4974@1|root,COG4974@2|Bacteria,1ZUA1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HFD3_k127_6158775_8	264732.Moth_1564	1.43e-05	51.0	COG1895@1|root,COG1895@2|Bacteria,1VG5F@1239|Firmicutes,24RT7@186801|Clostridia,42HF6@68295|Thermoanaerobacterales	186801|Clostridia	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
HFD3_k127_6158775_5	760568.Desku_2177	4.298e-18	87.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HFD3_k127_6158775_4	1173028.ANKO01000020_gene5476	8.395e-20	95.0	COG2442@1|root,COG2442@2|Bacteria,1G9FC@1117|Cyanobacteria,1HDDA@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD3_k127_6158775_6	1382306.JNIM01000001_gene2776	6.306e-14	76.0	COG4096@1|root,COG4096@2|Bacteria,2G6UT@200795|Chloroflexi	200795|Chloroflexi	L	Type III restriction protein res subunit	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	CarboxypepD_reg,EcoEI_R_C,HSDR_N,Helicase_C,ResIII
HFD3_k127_6158775_7	177439.DP3024	4.698e-11	65.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,2MMSY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HFD3_k127_6158775_0	1403819.BATR01000093_gene2865	7.941e-113	372.0	COG0412@1|root,COG0412@2|Bacteria,46UHK@74201|Verrucomicrobia,2ITZ5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD3_k127_6158775_1	443152.MDG893_15467	8.483e-59	218.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_6158775_2	472759.Nhal_3591	2.504e-37	142.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,1WZ3Q@135613|Chromatiales	135613|Chromatiales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD3_k127_6200429_27	765910.MARPU_02225	1.45e-07	54.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales	135613|Chromatiales	E	PFAM Amino acid-binding ACT	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
HFD3_k127_6200429_23	641491.DND132_0960	1.117e-26	127.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42PUB@68525|delta/epsilon subdivisions,2WMH5@28221|Deltaproteobacteria,2M93I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HFD3_k127_6200429_19	1038860.AXAP01000097_gene5007	1.333e-33	142.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,3K1ZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_6200429_0	1121904.ARBP01000005_gene4736	4.611e-278	870.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,47KWW@768503|Cytophagia	976|Bacteroidetes	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD3_k127_6200429_8	1121904.ARBP01000013_gene331	3.961e-104	359.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47JRM@768503|Cytophagia	976|Bacteroidetes	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat
HFD3_k127_6200429_3	1122604.JONR01000012_gene3431	2.261e-129	415.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1RPGX@1236|Gammaproteobacteria,1X30M@135614|Xanthomonadales	135614|Xanthomonadales	Q	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_6200429_18	509635.N824_20700	1.9e-35	139.0	COG2259@1|root,COG2259@2|Bacteria,4NYPC@976|Bacteroidetes,1IZT9@117747|Sphingobacteriia	976|Bacteroidetes	S	SURF4 family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX,SURF4
HFD3_k127_6200429_10	1286093.C266_19091	1.206e-92	312.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2VIK2@28216|Betaproteobacteria,1K4R8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_6200429_1	1267533.KB906748_gene55	1.059e-181	575.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_6200429_14	748247.AZKH_2523	3.13e-52	190.0	COG3224@1|root,COG3224@2|Bacteria,1RFVR@1224|Proteobacteria	1224|Proteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
HFD3_k127_6200429_24	292564.Cyagr_2797	6.616e-17	87.0	COG2259@1|root,COG2259@2|Bacteria,1G6SJ@1117|Cyanobacteria	1117|Cyanobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD3_k127_6200429_11	251221.35212389	1.005e-85	289.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD3_k127_6200429_16	330214.NIDE0008	1.698e-44	166.0	COG2259@1|root,COG2259@2|Bacteria,3J13I@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD3_k127_6200429_22	359.CN09_33115	5.752e-30	132.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2U6AN@28211|Alphaproteobacteria,4BM26@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_6200429_4	469383.Cwoe_1058	2.734e-118	396.0	COG0044@1|root,COG0044@2|Bacteria,2GKEC@201174|Actinobacteria,4CRXW@84995|Rubrobacteria	84995|Rubrobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.3	ko:K01464,ko:K01465	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046,M00051	R01993,R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HFD3_k127_6200429_13	264198.Reut_B5286	4.382e-60	221.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VP7Y@28216|Betaproteobacteria,1KBE5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_6200429_20	1192868.CAIU01000003_gene333	4.573e-33	139.0	COG1024@1|root,COG1024@2|Bacteria,1PHTY@1224|Proteobacteria,2V7VY@28211|Alphaproteobacteria,43NBZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_6200429_21	1207058.L53_05860	1.125e-32	139.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria,43Y1C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD3_k127_6200429_26	479432.Sros_1820	1.017e-12	79.0	COG0715@1|root,COG0715@2|Bacteria,2I9KK@201174|Actinobacteria,4EIQA@85012|Streptosporangiales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6200429_2	1121468.AUBR01000028_gene1511	1.543e-132	449.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HFD3_k127_6200429_17	331869.BAL199_03474	4.832e-37	151.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2VF6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_6200429_25	446462.Amir_4888	6.762e-17	93.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4E27N@85010|Pseudonocardiales	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6200429_12	1279038.KB907342_gene2613	5.82e-82	280.0	COG4106@1|root,COG4106@2|Bacteria,1R04W@1224|Proteobacteria,2U5VR@28211|Alphaproteobacteria,2JRTB@204441|Rhodospirillales	204441|Rhodospirillales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD3_k127_6200429_9	1379698.RBG1_1C00001G1665	4.441e-103	348.0	COG0845@1|root,COG0845@2|Bacteria,2NQ2U@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	acrA	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD3_k127_6200429_7	1379698.RBG1_1C00001G1666	1.525e-104	343.0	COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_6200429_6	909663.KI867150_gene1012	7.416e-112	374.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2MQUU@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_6200429_5	1288494.EBAPG3_28940	2.704e-116	387.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,2VMYG@28216|Betaproteobacteria,374K0@32003|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_6200429_15	1123023.JIAI01000001_gene6559	1.096e-46	173.0	COG0252@1|root,COG0252@2|Bacteria,2HUB2@201174|Actinobacteria,4E3K5@85010|Pseudonocardiales	201174|Actinobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HFD3_k127_6200540_3	675635.Psed_4190	4.278e-12	78.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,4E27N@85010|Pseudonocardiales	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6200540_0	1353537.TP2_09150	3.104e-27	114.0	2B1WH@1|root,30C4Q@2|Bacteria,1R3E9@1224|Proteobacteria,2U7UN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HFD3_k127_6200540_2	1122176.KB903619_gene5299	2.722e-12	73.0	2A3Y3@1|root,30SGF@2|Bacteria,4NZA3@976|Bacteroidetes,1IZPV@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6200540_4	189753.AXAS01000075_gene6004	8.558e-05	47.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_6200540_1	864073.HFRIS_004613	6.733e-13	75.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,4743U@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	pleD	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HFD3_k127_6217380_3	716928.AJQT01000080_gene2245	9.83e-33	139.0	COG2358@1|root,COG2358@2|Bacteria,1R8QD@1224|Proteobacteria,2U7M9@28211|Alphaproteobacteria,4BGNX@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_6217380_0	675635.Psed_3034	1.436e-111	377.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_6217380_1	240015.ACP_1122	1.448e-82	293.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria,2JJV3@204432|Acidobacteriia	204432|Acidobacteriia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6217380_2	1007105.PT7_3292	1.061e-34	140.0	COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2VS89@28216|Betaproteobacteria,3T3PQ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Alkylhydroperoxidase AhpD family core domain-containing protein 7	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD3_k127_6224586_4	1382356.JQMP01000003_gene1622	1.451e-15	79.0	COG0438@1|root,COG0438@2|Bacteria,2G8GB@200795|Chloroflexi,27XSA@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_6224586_3	1212548.B381_21036	2.653e-17	83.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1TAWJ@1236|Gammaproteobacteria,1Z3EZ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HFD3_k127_6224586_1	909613.UO65_0943	1.302e-57	208.0	COG0664@1|root,COG0664@2|Bacteria,2INMI@201174|Actinobacteria,4EBXN@85010|Pseudonocardiales	201174|Actinobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_6224586_0	706587.Desti_2467	2.049e-107	361.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MQA6@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD3_k127_6224586_2	1380350.JIAP01000018_gene178	1.421e-35	144.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	pagL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008653,GO:0009279,GO:0009311,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0042802,GO:0042803,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046493,GO:0046983,GO:0050528,GO:0052689,GO:0071704,GO:0071944,GO:1901135,GO:1901269,GO:1903509	-	ko:K12976,ko:K16079	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.4.2.1	-	-	OMP_b-brl,PagL
HFD3_k127_6225965_3	1365176.N186_03580	5.092e-12	72.0	COG0467@1|root,arCOG01171@2157|Archaea,2XRYY@28889|Crenarchaeota	28889|Crenarchaeota	T	Circadian clock protein KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HFD3_k127_6225965_1	1048339.KB913029_gene69	2.007e-123	399.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4ERFH@85013|Frankiales	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
HFD3_k127_6225965_0	671143.DAMO_1993	6.869e-288	895.0	COG1053@1|root,COG1053@2|Bacteria,2NNR9@2323|unclassified Bacteria	2|Bacteria	C	succinate dehydrogenase, flavoprotein subunit	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD3_k127_6225965_2	1157637.KB892113_gene4998	2.632e-86	292.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6230982_5	1122915.AUGY01000118_gene6536	3.757e-18	93.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6230982_2	497964.CfE428DRAFT_4603	2.896e-66	242.0	COG0349@1|root,COG0349@2|Bacteria,46SUU@74201|Verrucomicrobia	74201|Verrucomicrobia	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HFD3_k127_6230982_4	1122915.AUGY01000020_gene6479	3.461e-22	109.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6230982_1	1068980.ARVW01000001_gene7982	1.406e-78	274.0	COG2267@1|root,COG2267@2|Bacteria,2IG48@201174|Actinobacteria	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_6230982_0	1510531.JQJJ01000010_gene2442	3.215e-92	310.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,3K48K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_6230982_3	686340.Metal_1408	1.931e-30	130.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD3_k127_6241486_10	1237149.C900_05597	2.841e-06	50.0	COG1361@1|root,COG1361@2|Bacteria,4PKPA@976|Bacteroidetes	976|Bacteroidetes	M	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB
HFD3_k127_6241486_3	247490.KSU1_C0185	7.696e-86	293.0	COG1721@1|root,COG1721@2|Bacteria,2IY2F@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD3_k127_6241486_9	879212.DespoDRAFT_01112	5.406e-13	72.0	2E4K0@1|root,32ZEZ@2|Bacteria,1NEXM@1224|Proteobacteria,42W2R@68525|delta/epsilon subdivisions,2WRPN@28221|Deltaproteobacteria,2MNZH@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6241486_2	1463857.JOFZ01000005_gene3352	4.707e-113	375.0	2C1EV@1|root,33RW1@2|Bacteria,2ICZG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6241486_8	909663.KI867150_gene1131	8.292e-16	81.0	COG4770@1|root,COG4770@2|Bacteria,1Q2C7@1224|Proteobacteria,437YM@68525|delta/epsilon subdivisions,2X9S9@28221|Deltaproteobacteria,2MSE4@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HFD3_k127_6241486_1	706587.Desti_4219	1.284e-163	522.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MQ5Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HFD3_k127_6241486_0	1094508.Tsac_0943	3.474e-176	566.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,42ESJ@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD3_k127_6241486_5	1499967.BAYZ01000184_gene4610	9.766e-63	237.0	COG0642@1|root,COG2205@2|Bacteria,2NQZ3@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD3_k127_6241486_7	706587.Desti_1058	3.259e-24	118.0	COG0745@1|root,COG3829@1|root,COG0745@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HTH_8,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Sigma54_activat
HFD3_k127_6241486_6	330214.NIDE3051	4.114e-47	173.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE3051|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6241486_4	330214.NIDE3050	1.965e-79	294.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HFD3_k127_6253957_5	1499967.BAYZ01000085_gene5179	1.148e-24	108.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_6253957_0	1125863.JAFN01000001_gene321	1.151e-152	494.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_6253957_3	1121405.dsmv_3246	2.279e-105	364.0	COG0472@1|root,COG1086@1|root,COG0472@2|Bacteria,COG1086@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2X5IH@28221|Deltaproteobacteria,2MQ3P@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
HFD3_k127_6253957_1	886293.Sinac_6462	6.988e-133	432.0	COG0451@1|root,COG0451@2|Bacteria,2IX7V@203682|Planctomycetes	203682|Planctomycetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD3_k127_6253957_2	671143.DAMO_0194	2.519e-128	438.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HFD3_k127_6253957_4	1156937.MFUM_700005	1.194e-33	144.0	COG1596@1|root,COG1596@2|Bacteria,46W8Y@74201|Verrucomicrobia,37GE6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Polysaccharide biosynthesis/export protein	wza	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HFD3_k127_6263371_14	1116369.KB890024_gene1665	1.791e-05	49.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051,ko:K15551,ko:K15556	ko00920,ko02010,map00920,map02010	M00188,M00435,M00437	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4,3.A.1.17.5	-	-	NMT1,NMT1_2
HFD3_k127_6263371_10	1173263.Syn7502_03004	5.663e-18	95.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6263371_11	706587.Desti_3711	6.597e-18	91.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD3_k127_6263371_13	502025.Hoch_6067	5.228e-09	63.0	COG0711@1|root,COG0711@2|Bacteria,1Q25M@1224|Proteobacteria,437SR@68525|delta/epsilon subdivisions,2X31U@28221|Deltaproteobacteria,2Z2TD@29|Myxococcales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD3_k127_6263371_12	706587.Desti_3709	1.18e-11	75.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MS4A@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD3_k127_6263371_8	96561.Dole_0600	5.836e-28	123.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD3_k127_6263371_1	316067.Geob_0449	2.807e-243	759.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,43T4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD3_k127_6263371_4	706587.Desti_3706	4.311e-84	287.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MQDF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HFD3_k127_6263371_0	316067.Geob_0447	1.356e-256	796.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,43TRP@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD3_k127_6263371_7	243231.GSU0114	2.772e-32	130.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,43V31@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HFD3_k127_6263371_2	443152.MDG893_15240	4.632e-178	572.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,1RYIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	ethanolamine utilization protein	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
HFD3_k127_6263371_6	1227454.C446_02607	2.414e-33	139.0	COG0697@1|root,arCOG00272@2157|Archaea,2XVSM@28890|Euryarchaeota,23S7J@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_6263371_9	1293047.CBMA010000052_gene3265	2.584e-21	104.0	COG0697@1|root,arCOG00272@2157|Archaea,2XVSM@28890|Euryarchaeota,23S7J@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_6264640_9	795797.C497_09468	1.016e-37	146.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XXT7@28890|Euryarchaeota,23WEB@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD3_k127_6264640_8	1131269.AQVV01000020_gene2207	8.368e-43	164.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase_like
HFD3_k127_6264640_14	1297570.MESS4_360107	1.555e-11	75.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,43H6C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6264640_11	525903.Taci_1137	8.392e-28	115.0	2AE14@1|root,313TT@2|Bacteria,3TB4Q@508458|Synergistetes	508458|Synergistetes	S	PFAM glycine reductase complex selenoprotein A	-	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HFD3_k127_6264640_13	1321778.HMPREF1982_04172	2.142e-12	68.0	2DR3E@1|root,33A02@2|Bacteria,1VKEX@1239|Firmicutes,24UH8@186801|Clostridia,26CD0@186813|unclassified Clostridiales	186801|Clostridia	S	Glycine reductase complex selenoprotein A	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HFD3_k127_6264640_1	1118054.CAGW01000024_gene481	1.365e-132	442.0	COG0332@1|root,COG0332@2|Bacteria,1TQSB@1239|Firmicutes,4HCJ1@91061|Bacilli	91061|Bacilli	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III
HFD3_k127_6264640_0	330214.NIDE1289	9.855e-245	775.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HFD3_k127_6264640_3	1304883.KI912532_gene2389	5.491e-60	213.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,2KWIF@206389|Rhodocyclales	206389|Rhodocyclales	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HFD3_k127_6264640_15	702450.CUW_0814	7.694e-05	53.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,3VQ7J@526524|Erysipelotrichia	526524|Erysipelotrichia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD3_k127_6264640_10	269799.Gmet_0936	1.751e-34	134.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,43V75@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	SMART HNH nuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
HFD3_k127_6264640_6	351160.RCIX86	2.803e-47	189.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_6264640_7	671143.DAMO_2968	3.448e-46	169.0	COG0251@1|root,COG0251@2|Bacteria,2NPSA@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Pentapeptide,Ribonuc_L-PSP
HFD3_k127_6264640_12	309799.DICTH_1705	4.003e-18	93.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HFD3_k127_6264640_4	42256.RradSPS_0124	3.388e-59	217.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HFD3_k127_6264640_2	484019.THA_1091	3.887e-60	213.0	COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae	200918|Thermotogae	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD3_k127_6264640_5	452652.KSE_65170	1.153e-53	203.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,2M2JG@2063|Kitasatospora	201174|Actinobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD3_k127_6265931_34	398767.Glov_1872	1.641e-37	145.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,43UVT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HFD3_k127_6265931_38	338963.Pcar_1420	1.367e-16	80.0	COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,43SRN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L35	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HFD3_k127_6265931_31	243231.GSU1516	1.326e-49	181.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,43USN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HFD3_k127_6265931_3	1121920.AUAU01000033_gene2756	1.009e-227	721.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HFD3_k127_6265931_35	933262.AXAM01000003_gene2818	2.134e-35	142.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,2MKMF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA-2	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD3_k127_6265931_18	1121468.AUBR01000038_gene1956	1.246e-114	386.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,42EMI@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD3_k127_6265931_0	316067.Geob_3293	0.0	1202.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,43SUG@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD3_k127_6265931_37	290315.Clim_1138	4.091e-17	89.0	COG1051@1|root,COG1051@2|Bacteria,1FFC0@1090|Chlorobi	1090|Chlorobi	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD3_k127_6265931_33	1268068.PG5_42060	2.75e-43	169.0	COG0726@1|root,COG3195@1|root,COG0726@2|Bacteria,COG3195@2|Bacteria,1MV3V@1224|Proteobacteria,1RPKM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HFD3_k127_6265931_25	264198.Reut_C6311	2.834e-76	273.0	COG0715@1|root,COG0715@2|Bacteria,1NS24@1224|Proteobacteria	1224|Proteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
HFD3_k127_6265931_4	765910.MARPU_14925	2.532e-217	692.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HFD3_k127_6265931_30	1121405.dsmv_2334	1.509e-50	190.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2MK7M@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HFD3_k127_6265931_29	1210884.HG799462_gene7872	1.16e-53	199.0	COG0095@1|root,COG0095@2|Bacteria,2J0D8@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HFD3_k127_6265931_1	1191523.MROS_0859	0.0	1141.0	COG2609@1|root,COG2609@2|Bacteria	2|Bacteria	C	pyruvate dehydrogenase (acetyl-transferring) activity	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HFD3_k127_6265931_22	472759.Nhal_2901	2.662e-98	336.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD3_k127_6265931_10	105559.Nwat_1144	1.799e-147	480.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
HFD3_k127_6265931_24	316067.Geob_2372	8.548e-78	269.0	COG0258@1|root,COG0328@1|root,COG0258@2|Bacteria,COG0328@2|Bacteria,1NRSF@1224|Proteobacteria,42YWE@68525|delta/epsilon subdivisions,2WTRZ@28221|Deltaproteobacteria,43SWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	5_3_exonuc,5_3_exonuc_N,RNase_H
HFD3_k127_6265931_17	243265.plu2234	1.063e-119	403.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	histidine ammonia-lyase	-	-	4.3.1.24	ko:K10775	ko00360,ko00940,ko01100,ko01110,map00360,map00940,map01100,map01110	M00039,M00137,M00350	R00697	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD3_k127_6265931_7	1469607.KK073768_gene3306	4.952e-171	550.0	COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,1HIDR@1161|Nostocales	1117|Cyanobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_6265931_19	1379698.RBG1_1C00001G1465	6.627e-113	376.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
HFD3_k127_6265931_6	1379698.RBG1_1C00001G1464	3.307e-187	591.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
HFD3_k127_6265931_28	1379698.RBG1_1C00001G1463	1.055e-58	208.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HFD3_k127_6265931_36	1379698.RBG1_1C00001G1462	1.482e-26	117.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HFD3_k127_6265931_8	485913.Krac_8263	1.848e-154	498.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD3_k127_6265931_11	1313301.AUGC01000008_gene475	4.291e-141	463.0	COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HFD3_k127_6265931_2	926550.CLDAP_25010	2.712e-268	842.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HFD3_k127_6265931_23	1304875.JAFZ01000001_gene1850	6.59e-78	271.0	COG1703@1|root,COG1703@2|Bacteria,3TAKB@508458|Synergistetes	508458|Synergistetes	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HFD3_k127_6265931_12	671143.DAMO_0590	4.91e-138	449.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	yngJ	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410,ko:K18244	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_6265931_32	28444.JODQ01000002_gene4319	4.084e-46	171.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4EJ0E@85012|Streptosporangiales	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HFD3_k127_6265931_5	330214.NIDE3118	3.389e-209	671.0	COG1884@1|root,COG1884@2|Bacteria	2|Bacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HFD3_k127_6265931_14	857293.CAAU_1824	2.32e-135	442.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,36DR1@31979|Clostridiaceae	186801|Clostridia	I	acyl-CoA dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD3_k127_6265931_15	1144275.COCOR_04192	2.23e-131	430.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2YUF5@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	bamN	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD3_k127_6265931_16	243231.GSU2654	3.129e-127	417.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,43UJJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD3_k127_6265931_13	867903.ThesuDRAFT_01197	5.002e-138	446.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia	186801|Clostridia	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD3_k127_6265931_20	243231.GSU2656	1.421e-108	364.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,43TUD@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	e3 binding domain	bkdF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD3_k127_6265931_26	604331.AUHY01000005_gene761	2.206e-68	243.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HFD3_k127_6265931_9	1379698.RBG1_1C00001G0508	1.085e-153	494.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K07508	ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00085,M00087,M00088,M00095,M00373,M00374,M00375	R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD3_k127_6265931_21	1232410.KI421421_gene3630	5.453e-107	360.0	COG2195@1|root,COG2195@2|Bacteria,1MV7D@1224|Proteobacteria,42MBD@68525|delta/epsilon subdivisions,2WJT1@28221|Deltaproteobacteria,43SAH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Peptidase family M28	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD3_k127_6265931_27	880074.BARVI_03745	1.328e-61	231.0	COG0724@1|root,COG2865@1|root,COG0724@2|Bacteria,COG2865@2|Bacteria,4NKG2@976|Bacteroidetes,2G2D2@200643|Bacteroidia	976|Bacteroidetes	K	Divergent AAA domain protein	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
HFD3_k127_6265931_40	1125863.JAFN01000001_gene2491	1.14e-06	54.0	COG4122@1|root,COG4122@2|Bacteria,1QWN3@1224|Proteobacteria,43DC9@68525|delta/epsilon subdivisions,2X8IA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD3_k127_6272657_3	365046.Rta_30510	1.66e-05	52.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,4ACV8@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_6272657_0	1348657.M622_05010	2.92e-262	836.0	COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	1.17.99.2	ko:K10700,ko:K17050	ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220	-	R05745	RC00275	ko00000,ko00001,ko01000,ko02000	5.A.3.8,5.A.3.9	-	-	Molybdopterin,Molydop_binding
HFD3_k127_6272657_2	1123508.JH636456_gene119	3.091e-27	120.0	COG3335@1|root,COG3335@2|Bacteria,2J1BU@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HFD3_k127_6272657_1	329726.AM1_2401	1.266e-68	238.0	COG0847@1|root,COG0847@2|Bacteria,1G66K@1117|Cyanobacteria	1117|Cyanobacteria	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD3_k127_6287962_9	1380394.JADL01000001_gene2534	3.459e-11	68.0	29799@1|root,2ZUGZ@2|Bacteria,1P46Y@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6287962_10	1380394.JADL01000001_gene2533	1.178e-05	51.0	294AC@1|root,2ZRQJ@2|Bacteria,1PA56@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6287962_8	56780.SYN_01527	9.031e-75	259.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MQEG@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	TIGRFAM signal peptidase I	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HFD3_k127_6287962_0	269799.Gmet_1766	9.018e-276	859.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,43UJT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD3_k127_6287962_5	378806.STAUR_4028	3.366e-112	370.0	COG0451@1|root,COG0451@2|Bacteria,1QX8V@1224|Proteobacteria,43C1V@68525|delta/epsilon subdivisions,2X5FV@28221|Deltaproteobacteria,2YY2H@29|Myxococcales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_6287962_2	518766.Rmar_1858	4.773e-147	472.0	COG0451@1|root,COG0451@2|Bacteria,4NEZX@976|Bacteroidetes,1FIS7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD3_k127_6287962_1	880073.Calab_3530	1.641e-175	561.0	COG1004@1|root,COG1004@2|Bacteria,2NNYN@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_6287962_4	1121403.AUCV01000020_gene3088	4.914e-117	384.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2MMID@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HFD3_k127_6287962_3	243231.GSU1113	4.326e-118	387.0	COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria,43S1S@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2683	PfkB
HFD3_k127_6287962_6	1267533.KB906733_gene3460	2.056e-106	353.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HFD3_k127_6287962_7	96561.Dole_2311	1.485e-100	338.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2MJ4T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HFD3_k127_6299252_2	338963.Pcar_2351	2.755e-26	115.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42U47@68525|delta/epsilon subdivisions,2WQXE@28221|Deltaproteobacteria,43UVW@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD3_k127_6299252_4	56780.SYN_02981	1.65e-08	59.0	COG3027@1|root,COG3027@2|Bacteria,1NK0Z@1224|Proteobacteria	1224|Proteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HFD3_k127_6299252_3	861299.J421_4337	1.377e-08	61.0	COG2010@1|root,COG2010@2|Bacteria,1ZUYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_6299252_1	420324.KI912061_gene6195	2.351e-34	140.0	COG1999@1|root,COG1999@2|Bacteria,1N6WC@1224|Proteobacteria,2VFHX@28211|Alphaproteobacteria	1224|Proteobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	AhpC-TSA,SCO1-SenC
HFD3_k127_6299252_0	1123368.AUIS01000024_gene953	6.405e-61	215.0	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,PrmA
HFD3_k127_6313041_0	675635.Psed_3034	3.537e-96	328.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_6313041_3	296591.Bpro_5254	1.611e-34	136.0	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2VV15@28216|Betaproteobacteria,4AJFM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HFD3_k127_6313041_1	1231190.NA8A_14544	6.853e-94	325.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,43KJI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6313041_2	443152.MDG893_15045	1.116e-35	137.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria	1224|Proteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_6315554_3	316067.Geob_2607	3.616e-83	293.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,43TAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD3_k127_6315554_0	269799.Gmet_1774	0.0	1512.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,43TR2@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD3_k127_6315554_2	1232410.KI421413_gene595	7.568e-168	536.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD3_k127_6315554_5	1507.HMPREF0262_02120	3.943e-74	273.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,36DT0@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
HFD3_k127_6315554_7	546271.Selsp_0857	3.738e-44	167.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,4H3ZG@909932|Negativicutes	909932|Negativicutes	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HFD3_k127_6315554_6	926560.KE387027_gene284	5.718e-53	192.0	COG0622@1|root,COG0622@2|Bacteria,1WMMY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM phosphoesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HFD3_k127_6315554_1	1476876.JOJO01000036_gene4375	1.583e-205	666.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_6315554_4	1297617.JPJD01000050_gene1926	1.038e-81	289.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,2697G@186813|unclassified Clostridiales	186801|Clostridia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_6326656_4	105420.BBPO01000001_gene55	3.51e-14	79.0	2A6YK@1|root,30VTJ@2|Bacteria,2IJ81@201174|Actinobacteria,2NKRK@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6326656_3	1227497.C491_10989	4.072e-23	110.0	COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,23RWQ@183963|Halobacteria	183963|Halobacteria	M	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HFD3_k127_6326656_2	439235.Dalk_2782	1.116e-102	364.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2MI3T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HFD3_k127_6326656_1	378806.STAUR_3365	1.96e-175	569.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HFD3_k127_6326656_0	316067.Geob_1232	4.082e-187	594.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,43U9W@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD3_k127_6354519_5	1214101.BN159_1049	7.695e-37	151.0	COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	serA3	-	1.1.1.26,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_6354519_7	317936.Nos7107_1401	3.648e-25	116.0	COG2267@1|root,COG2267@2|Bacteria,1G4F2@1117|Cyanobacteria,1HMVC@1161|Nostocales	1117|Cyanobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HFD3_k127_6354519_6	999541.bgla_1g15090	4.721e-26	118.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6354519_3	1316927.ATKI01000034_gene4768	3.961e-51	187.0	COG4447@1|root,COG4447@2|Bacteria,1PEJV@1224|Proteobacteria,1SXSZ@1236|Gammaproteobacteria,1YMT2@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD3_k127_6354519_1	319795.Dgeo_2171	8.823e-103	343.0	COG0667@1|root,COG0667@2|Bacteria,1WJR8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_6354519_2	1382306.JNIM01000001_gene587	1.504e-94	319.0	COG1237@1|root,COG1237@2|Bacteria,2G73K@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HFD3_k127_6354519_8	59374.Fisuc_1897	1.205e-06	60.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarboxypepD_reg,MORN_2,TonB_C
HFD3_k127_6354519_0	744872.Spica_1210	1.765e-133	435.0	COG0075@1|root,COG0075@2|Bacteria,2J84T@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD3_k127_6354519_4	272558.10174624	3.593e-46	172.0	COG0179@1|root,COG0179@2|Bacteria,1U3FY@1239|Firmicutes,4IFHA@91061|Bacilli,1ZEY2@1386|Bacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_6358582_4	1379281.AVAG01000018_gene1053	1.014e-57	204.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2M8YN@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HFD3_k127_6358582_0	483219.LILAB_21205	1.784e-117	390.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2YTTG@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
HFD3_k127_6358582_2	460265.Mnod_2984	2.177e-84	291.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,1JRKB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_6358582_7	1120983.KB894573_gene200	6.563e-35	146.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,1JPUA@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6358582_3	1416752.AYME01000017_gene1951	7.568e-59	213.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4FPFE@85023|Microbacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_6358582_9	671143.DAMO_2824	1.397e-10	64.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD3_k127_6358582_6	1121405.dsmv_3242	1.3e-36	142.0	COG0824@1|root,COG0824@2|Bacteria,1PEBE@1224|Proteobacteria,42TIA@68525|delta/epsilon subdivisions,2WQ9X@28221|Deltaproteobacteria,2MMDF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD3_k127_6358582_5	1532558.JL39_00805	2.217e-44	173.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,4B76P@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Trypsin-like peptidase domain	MA20_20705	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HFD3_k127_6358582_1	243231.GSU0367	5.093e-95	324.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2WIPW@28221|Deltaproteobacteria,43TZ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SMART Elongator protein 3 MiaB NifB	yhcC-1	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
HFD3_k127_6358582_8	56780.SYN_02362	4.798e-23	109.0	COG1399@1|root,COG1399@2|Bacteria,1N7GQ@1224|Proteobacteria,42U2P@68525|delta/epsilon subdivisions,2WRMV@28221|Deltaproteobacteria,2MS4U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HFD3_k127_6384574_3	1279019.ARQK01000058_gene745	9.067e-21	98.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh,Nitrate_red_del
HFD3_k127_6384574_4	1158150.KB906246_gene1912	3.635e-06	58.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh,Nitrate_red_del
HFD3_k127_6384574_0	479434.Sthe_2205	1.377e-85	301.0	COG0477@1|root,COG0477@2|Bacteria,2G89T@200795|Chloroflexi,27Y75@189775|Thermomicrobia	2|Bacteria	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_6384574_1	1125863.JAFN01000001_gene1152	2.288e-62	230.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,42RXH@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_6392622_2	935840.JAEQ01000004_gene641	6.619e-165	532.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,43HM4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_6392622_4	1429916.X566_14890	2.258e-143	460.0	COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,3K3FV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_6392622_8	653045.Strvi_4346	9.182e-21	101.0	COG0346@1|root,COG0346@2|Bacteria,2IIN9@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,Glyoxalase
HFD3_k127_6392622_6	765913.ThidrDRAFT_0162	8e-42	177.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HFD3_k127_6392622_0	472759.Nhal_0667	0.0	1020.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales	135613|Chromatiales	T	PFAM PrkA AAA	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HFD3_k127_6392622_3	472759.Nhal_0668	1.392e-159	511.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HFD3_k127_6392622_1	472759.Nhal_0669	1.587e-195	621.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales	135613|Chromatiales	S	SpoVR family	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HFD3_k127_6392622_7	1297617.JPJD01000013_gene950	2.779e-35	149.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,268K7@186813|unclassified Clostridiales	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HFD3_k127_6392622_5	1381123.AYOD01000013_gene2195	2.127e-77	265.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,43I4Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_6414840_0	452637.Oter_3359	0.0	1022.0	COG1643@1|root,COG1643@2|Bacteria,46TMT@74201|Verrucomicrobia,3K7J2@414999|Opitutae	414999|Opitutae	L	ATP-dependent helicase C-terminal	-	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HFD3_k127_6414840_4	1502851.FG93_03985	0.0001106	55.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TVI7@28211|Alphaproteobacteria,3JQXF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	MA20_03680	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HFD3_k127_6414840_2	204669.Acid345_2055	6.37e-19	101.0	COG2982@1|root,COG2982@2|Bacteria,3Y2J8@57723|Acidobacteria,2JKPW@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD3_k127_6414840_1	452637.Oter_0694	3.682e-185	591.0	COG5310@1|root,COG5310@2|Bacteria	2|Bacteria	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HFD3_k127_6414840_3	228410.NE0909	5.009e-17	87.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD3_k127_6416175_12	1121468.AUBR01000001_gene508	5.626e-59	212.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,42FA6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Nucleotidyl transferase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_6416175_13	1382306.JNIM01000001_gene1856	3.089e-55	207.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi	200795|Chloroflexi	J	Responsible for synthesis of pseudouridine from uracil	-	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD3_k127_6416175_11	671143.DAMO_2097	7.684e-69	243.0	COG2853@1|root,COG2853@2|Bacteria,2NRQC@2323|unclassified Bacteria	2|Bacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HFD3_k127_6416175_2	316067.Geob_3527	6.191e-139	452.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,43U1Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD3_k127_6416175_16	247490.KSU1_D0285	4.967e-37	145.0	2CA4A@1|root,32RQK@2|Bacteria,2J0BM@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
HFD3_k127_6416175_10	404589.Anae109_1500	6.793e-78	269.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD3_k127_6416175_5	706587.Desti_4373	1.806e-107	362.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MQRK@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
HFD3_k127_6416175_6	319225.Plut_1305	3.38e-102	338.0	COG0330@1|root,COG0330@2|Bacteria,1FE5T@1090|Chlorobi	1090|Chlorobi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD3_k127_6416175_7	648996.Theam_1729	4.378e-99	335.0	COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae	200783|Aquificae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HFD3_k127_6416175_3	1379858.N508_00503	2.315e-135	447.0	COG0343@1|root,COG0343@2|Bacteria,2GEWX@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD3_k127_6416175_17	706587.Desti_4871	1.151e-23	104.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MQKT@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HFD3_k127_6416175_0	56780.SYN_01524	8.352e-163	528.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD3_k127_6416175_9	1232410.KI421418_gene2299	4.912e-84	289.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,43RZY@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	SecD/SecF GG Motif	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD3_k127_6416175_1	404589.Anae109_1327	8.051e-153	501.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2WJE3@28221|Deltaproteobacteria,2YTVE@29|Myxococcales	28221|Deltaproteobacteria	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HFD3_k127_6416175_18	1122915.AUGY01000118_gene6536	1.295e-22	110.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6416175_22	1406840.Q763_16120	0.0002009	46.0	COG1738@1|root,COG1738@2|Bacteria,4NNPU@976|Bacteroidetes,1I2GG@117743|Flavobacteriia,2NU67@237|Flavobacterium	976|Bacteroidetes	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HFD3_k127_6416175_21	376686.Fjoh_1607	2.889e-07	53.0	COG1738@1|root,COG1738@2|Bacteria,4NNPU@976|Bacteroidetes,1I2GG@117743|Flavobacteriia,2NU67@237|Flavobacterium	976|Bacteroidetes	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HFD3_k127_6416175_14	671143.DAMO_1116	7.138e-50	190.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_6416175_15	644282.Deba_3291	3.147e-39	163.0	COG2203@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,GerE,HATPase_c,HisKA
HFD3_k127_6416175_4	330214.NIDE3942	4.874e-123	409.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_6416175_19	1288963.ADIS_2866	1.954e-12	72.0	COG0745@1|root,COG0745@2|Bacteria,4NSHT@976|Bacteroidetes,47REC@768503|Cytophagia	976|Bacteroidetes	KT	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_6416175_8	300852.55772857	3.072e-93	315.0	COG0616@1|root,COG0616@2|Bacteria,1WIZG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	OU	COGs COG0616 Periplasmic serine protease (ClpP class)	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
HFD3_k127_6416175_20	269799.Gmet_1015	2.168e-10	69.0	2C1UW@1|root,32XSR@2|Bacteria,1N37G@1224|Proteobacteria	1224|Proteobacteria	S	YfdX protein	-	-	-	-	-	-	-	-	-	-	-	-	YfdX
HFD3_k127_6418671_0	948106.AWZT01000001_gene5077	2.299e-134	437.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2WBWM@28216|Betaproteobacteria,1K6TM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_6418671_4	379066.GAU_3508	2.3e-07	55.0	COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
HFD3_k127_6418671_1	1485544.JQKP01000001_gene1268	5.802e-62	235.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,44V80@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HFD3_k127_6418671_3	1499967.BAYZ01000014_gene6407	3.337e-27	112.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_6418671_2	1499967.BAYZ01000014_gene6407	5.128e-32	126.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_6432410_0	1280001.BAOA01000073_gene3300	1.202e-83	302.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1XVBR@135623|Vibrionales	135623|Vibrionales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HFD3_k127_6432410_2	13689.BV96_02976	7.091e-54	201.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,2K1BU@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM amidohydrolase 2	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_6432410_1	936455.KI421499_gene61	2.781e-83	284.0	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2U19G@28211|Alphaproteobacteria,3JUI5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_6432410_4	665956.HMPREF1032_00435	9.415e-15	85.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,3WHSG@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6432410_3	1221522.B723_18525	1.453e-43	164.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,1S8P8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_6440652_3	335543.Sfum_1456	7.345e-90	310.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HFD3_k127_6440652_0	1304885.AUEY01000002_gene358	0.0	1291.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD3_k127_6440652_2	1304885.AUEY01000002_gene359	3.162e-102	347.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MJRC@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HFD3_k127_6440652_8	314285.KT71_03137	3.181e-12	67.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1J8Z6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,SDF
HFD3_k127_6440652_5	335543.Sfum_1481	1.443e-19	93.0	2DRBR@1|root,33B4T@2|Bacteria,1NHJT@1224|Proteobacteria,43EE5@68525|delta/epsilon subdivisions,2WSXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
HFD3_k127_6440652_9	1300345.LF41_2217	2.742e-07	57.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,1RMVF@1236|Gammaproteobacteria,1X79A@135614|Xanthomonadales	135614|Xanthomonadales	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
HFD3_k127_6440652_6	312153.Pnuc_2048	8.479e-16	84.0	2E560@1|root,32ZYT@2|Bacteria,1N9G1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6440652_12	1215114.BBIU01000007_gene1300	0.0009181	45.0	COG3659@1|root,COG3659@2|Bacteria,1R71M@1224|Proteobacteria,1S128@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Carbohydrate-selective porin	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
HFD3_k127_6440652_4	1500306.JQLA01000003_gene4503	4.307e-30	124.0	2E560@1|root,32ZYT@2|Bacteria,1RD6P@1224|Proteobacteria,2UJ9J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6440652_10	309807.SRU_0346	8.166e-06	53.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1FJ6B@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycine zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA,PD40
HFD3_k127_6440652_11	1247963.JPHU01000008_gene2890	0.0001288	50.0	COG3409@1|root,COG3409@2|Bacteria,1ND4S@1224|Proteobacteria,2UJRX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD3_k127_6440652_1	909663.KI867149_gene3370	9.518e-164	535.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD3_k127_6440652_7	159450.NH14_15205	5.727e-13	72.0	2AGC9@1|root,316HY@2|Bacteria,1PXMI@1224|Proteobacteria,2WD0V@28216|Betaproteobacteria,1K8YX@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6442577_2	1283283.ATXA01000004_gene4444	6.409e-49	183.0	COG2843@1|root,COG2843@2|Bacteria,2IA16@201174|Actinobacteria	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HFD3_k127_6442577_1	1231391.AMZF01000046_gene961	8.669e-51	194.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_6442577_4	1232410.KI421424_gene1780	2.472e-35	138.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42UPV@68525|delta/epsilon subdivisions,2WQB6@28221|Deltaproteobacteria,43UXF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD3_k127_6442577_3	1131269.AQVV01000018_gene1932	5.643e-44	166.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HFD3_k127_6442577_0	1131269.AQVV01000006_gene491	8.364e-93	311.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HFD3_k127_6448364_0	1232410.KI421413_gene952	1.794e-258	822.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,4378Y@68525|delta/epsilon subdivisions,2X2C1@28221|Deltaproteobacteria,43UD2@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD3_k127_6448364_2	1123073.KB899242_gene948	1.585e-53	199.0	COG0457@1|root,COG0789@1|root,COG0457@2|Bacteria,COG0789@2|Bacteria,1NP3J@1224|Proteobacteria	1224|Proteobacteria	K	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
HFD3_k127_6448364_1	1192034.CAP_1429	1.047e-73	258.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD3_k127_6448364_4	314265.R2601_10062	3.543e-16	85.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	csbD	-	-	-	-	-	-	-	-	-	-	-	CsbD
HFD3_k127_6448364_5	1283284.AZUK01000001_gene1357	5.885e-06	53.0	COG5510@1|root,COG5510@2|Bacteria	2|Bacteria	S	response to toxic substance	ecnB	-	-	ko:K16347,ko:K16348	-	-	-	-	ko00000,ko02000	9.B.13.1.1	-	-	Entericidin
HFD3_k127_6448364_3	1167006.UWK_00212	1.911e-33	137.0	COG3047@1|root,COG3047@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OMP_b-brl,OmpA_like
HFD3_k127_6473066_4	469610.HMPREF0189_00442	1.963e-140	460.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KP92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HFD3_k127_6473066_11	1379858.N508_00221	2.759e-38	163.0	COG1027@1|root,COG1027@2|Bacteria,2GGQ2@200930|Deferribacteres	200930|Deferribacteres	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD3_k127_6473066_2	1366050.N234_35850	4.197e-227	713.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KGZR@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HFD3_k127_6473066_5	742823.HMPREF9465_00299	1.175e-117	382.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HFD3_k127_6473066_1	469610.HMPREF0189_00997	0.0	1009.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD3_k127_6473066_6	1304883.KI912532_gene2945	1.066e-94	316.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,2VURZ@28216|Betaproteobacteria,2KYHM@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HFD3_k127_6473066_3	204669.Acid345_0452	1.168e-160	519.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	204432|Acidobacteriia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HFD3_k127_6473066_9	641491.DND132_3094	3.248e-67	248.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42PH3@68525|delta/epsilon subdivisions,2WJZH@28221|Deltaproteobacteria,2MEDH@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HFD3_k127_6473066_8	439235.Dalk_1855	7.403e-80	275.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria,2MN9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,NrfD
HFD3_k127_6473066_0	439235.Dalk_1854	0.0	1023.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HFD3_k127_6473066_10	443144.GM21_1955	9.603e-58	209.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HFD3_k127_6473066_12	246197.MXAN_2209	1.072e-29	124.0	COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,2YUSH@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
HFD3_k127_6473066_7	335543.Sfum_1456	4.333e-86	296.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HFD3_k127_6485875_0	748247.AZKH_2419	1.09e-204	673.0	COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,2WGYX@28216|Betaproteobacteria,2KZX3@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HFD3_k127_6485875_2	1045855.DSC_06015	5.912e-48	185.0	2AQ2A@1|root,31F7E@2|Bacteria,1QCMG@1224|Proteobacteria,1T8CS@1236|Gammaproteobacteria,1XAFU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6485875_1	491915.Aflv_0876	4.699e-78	266.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,21V6K@150247|Anoxybacillus	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD3_k127_6485875_4	518766.Rmar_1363	9.145e-15	76.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_6485875_3	1121918.ARWE01000001_gene2194	2.443e-22	98.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria,43VJI@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6495301_9	1120973.AQXL01000130_gene1244	2.102e-14	81.0	COG5424@1|root,COG5424@2|Bacteria,1VNTM@1239|Firmicutes,4HSNP@91061|Bacilli	91061|Bacilli	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HFD3_k127_6495301_3	675635.Psed_2624	7.424e-65	231.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria,4E76K@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD3_k127_6495301_2	266265.Bxe_B2813	5.043e-68	243.0	COG0329@1|root,COG0329@2|Bacteria,1NQJ0@1224|Proteobacteria	1224|Proteobacteria	EM	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_6495301_1	1128421.JAGA01000002_gene1959	4.027e-109	365.0	COG0446@1|root,COG0446@2|Bacteria,2NPPU@2323|unclassified Bacteria	2|Bacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD3_k127_6495301_5	1382303.JPOM01000001_gene300	1.426e-43	167.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2KGDQ@204458|Caulobacterales	204458|Caulobacterales	S	Peptidase S16, lon domain protein	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HFD3_k127_6495301_4	671143.DAMO_1713	2.187e-52	199.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HFD3_k127_6495301_6	1122929.KB908224_gene3465	1.035e-39	152.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2U5ES@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	MA20_43165	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD3_k127_6495301_8	1304888.ATWF01000001_gene1269	1.055e-19	92.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,Cupin_3
HFD3_k127_6495301_0	264198.Reut_C6311	2.69e-115	379.0	COG0715@1|root,COG0715@2|Bacteria,1NS24@1224|Proteobacteria	1224|Proteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
HFD3_k127_6495301_7	909663.KI867150_gene2166	5.389e-23	100.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MRPA@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_6515452_7	56780.SYN_00807	7.181e-05	52.0	COG4274@1|root,COG4274@2|Bacteria,1N83R@1224|Proteobacteria,431NX@68525|delta/epsilon subdivisions,2WWPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HFD3_k127_6515452_3	497321.C664_07178	5.642e-43	164.0	COG4273@1|root,COG4273@2|Bacteria,1MZN7@1224|Proteobacteria,2W34Q@28216|Betaproteobacteria,2KZ1R@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF2703)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
HFD3_k127_6515452_1	477974.Daud_1143	2.085e-99	336.0	COG0430@1|root,COG0430@2|Bacteria	2|Bacteria	A	RNA-3'-phosphate cyclase activity	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
HFD3_k127_6515452_2	1283300.ATXB01000001_gene820	1.153e-84	288.0	COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria,1SJIV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
HFD3_k127_6515452_5	1082933.MEA186_07864	1.106e-25	112.0	COG2863@1|root,COG2863@2|Bacteria,1R279@1224|Proteobacteria,2TZC9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_6515452_4	309801.trd_1809	2.013e-36	149.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_6515452_0	439235.Dalk_1952	1.495e-135	444.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MN11@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HFD3_k127_6515452_6	766499.C357_05818	1.545e-18	94.0	COG2863@1|root,COG2863@2|Bacteria,1N04Z@1224|Proteobacteria,2TWJ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_6527343_6	468059.AUHA01000002_gene563	1.805e-104	366.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
HFD3_k127_6527343_1	1382306.JNIM01000001_gene1617	1.013e-160	519.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD3_k127_6527343_2	562970.Btus_2619	8.595e-128	421.0	COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,4HAY9@91061|Bacilli,278U1@186823|Alicyclobacillaceae	91061|Bacilli	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HFD3_k127_6527343_12	485913.Krac_10288	4.671e-66	242.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD3_k127_6527343_10	1122604.JONR01000010_gene3925	3.35e-68	247.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X55Z@135614|Xanthomonadales	135614|Xanthomonadales	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
HFD3_k127_6527343_17	105422.BBPM01000048_gene1690	1.757e-35	146.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria,2NJU9@228398|Streptacidiphilus	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HFD3_k127_6527343_8	485913.Krac_7281	1.591e-79	274.0	COG1028@1|root,COG1028@2|Bacteria,2G6GQ@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.140	ko:K00059,ko:K00068	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05607,R07759,R07763,R10116,R10120,R11671	RC00029,RC00085,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_6527343_3	386456.JQKN01000010_gene655	1.724e-124	410.0	COG5276@1|root,arCOG02565@2157|Archaea	2157|Archaea	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HFD3_k127_6527343_7	868864.Dester_0409	4.185e-93	310.0	COG0177@1|root,COG0177@2|Bacteria,2G3TX@200783|Aquificae	200783|Aquificae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD3_k127_6527343_16	1261545.MBE-HAL_2403	2.777e-37	147.0	COG0494@1|root,arCOG01072@2157|Archaea,2XWJS@28890|Euryarchaeota,23VF0@183963|Halobacteria	183963|Halobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD3_k127_6527343_22	247490.KSU1_D0462	6.993e-14	79.0	COG1917@1|root,COG1917@2|Bacteria,2J3IF@203682|Planctomycetes	203682|Planctomycetes	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_6527343_24	1173027.Mic7113_1029	4.765e-06	50.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	1117|Cyanobacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_6527343_18	589924.Ferp_1571	2.022e-34	143.0	COG2159@1|root,arCOG01933@2157|Archaea,2Y7I7@28890|Euryarchaeota,246BB@183980|Archaeoglobi	183980|Archaeoglobi	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_6527343_21	1122915.AUGY01000020_gene6479	2.529e-17	94.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6527343_0	748247.AZKH_0565	6.203e-172	566.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUV9@206389|Rhodocyclales	206389|Rhodocyclales	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HFD3_k127_6527343_15	1232437.KL662016_gene1010	3.272e-42	170.0	COG4447@1|root,COG4447@2|Bacteria,1PK4G@1224|Proteobacteria,431VP@68525|delta/epsilon subdivisions,2WW8N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HFD3_k127_6527343_19	1499686.BN1079_00578	1.715e-26	123.0	2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HFD3_k127_6527343_20	1198232.CYCME_1634	9.368e-21	107.0	COG3419@1|root,COG3419@2|Bacteria	2|Bacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilC	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
HFD3_k127_6527343_11	269799.Gmet_2367	3.321e-67	248.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,43TVN@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD3_k127_6527343_14	481448.Minf_0142	8.603e-48	181.0	COG4798@1|root,COG4798@2|Bacteria,46T4I@74201|Verrucomicrobia,37GDY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_6527343_4	1047013.AQSP01000037_gene1322	1.729e-112	378.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294,ko:K13868	ko04974,map04974	-	-	-	ko00000,ko00001,ko02000	2.A.3.2,2.A.3.8.15	-	-	AA_permease_2
HFD3_k127_6527343_13	330214.NIDE2666	4.709e-58	213.0	COG2096@1|root,COG2096@2|Bacteria	2|Bacteria	S	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.2.1.88,1.5.5.2,2.5.1.17	ko:K00798,ko:K13821	ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130	M00122	R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268	RC00080,RC00083,RC00216,RC00242,RC00255,RC00533	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Cob_adeno_trans
HFD3_k127_6527343_9	189753.AXAS01000041_gene2534	1.524e-76	273.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_6527343_5	443143.GM18_2682	8.299e-105	347.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,43UK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_6527343_23	4572.TRIUR3_18768-P1	2.439e-09	61.0	COG0607@1|root,KOG1530@2759|Eukaryota,37UIG@33090|Viridiplantae,3GJMQ@35493|Streptophyta,3KZVK@4447|Liliopsida,3IHT5@38820|Poales	35493|Streptophyta	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HFD3_k127_6553776_2	706587.Desti_2694	6.58e-131	427.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
HFD3_k127_6553776_1	1267535.KB906767_gene4059	7.403e-164	528.0	COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria,2JIIN@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_6553776_3	102232.GLO73106DRAFT_00011930	8.701e-85	293.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_6553776_0	402777.KB235903_gene853	2.533e-184	595.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,1H8M6@1150|Oscillatoriales	1117|Cyanobacteria	H	Protoporphyrinogen oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD3_k127_6553776_5	1198232.CYCME_1453	4.941e-07	56.0	COG1232@1|root,COG1232@2|Bacteria,1QX3T@1224|Proteobacteria,1T3RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HFD3_k127_6553776_4	32057.KB217478_gene2741	1.558e-27	121.0	COG3307@1|root,COG3307@2|Bacteria,1G1VH@1117|Cyanobacteria,1HM4H@1161|Nostocales	1117|Cyanobacteria	M	PFAM O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD3_k127_6576334_9	1121447.JONL01000009_gene2617	5.198e-27	111.0	COG0303@1|root,COG0303@2|Bacteria,1QUKM@1224|Proteobacteria,42NTF@68525|delta/epsilon subdivisions,2WKN1@28221|Deltaproteobacteria,2M95Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD3_k127_6576334_3	697282.Mettu_2210	2.22e-112	371.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,1SMMC@1236|Gammaproteobacteria,1XG20@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD3_k127_6576334_5	395963.Bind_2522	1.029e-66	235.0	COG3848@1|root,COG3848@2|Bacteria,1R7DS@1224|Proteobacteria,2U3SK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6576334_2	1040989.AWZU01000073_gene3947	7.108e-115	378.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria,3K2CR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HFD3_k127_6576334_1	381666.H16_B1483	7.897e-126	415.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1K55C@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_6576334_6	1151127.KB906326_gene748	6.871e-50	181.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,1RUTW@1236|Gammaproteobacteria,1YS6D@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HFD3_k127_6576334_11	1040986.ATYO01000003_gene5861	4.048e-12	67.0	COG0053@1|root,COG0053@2|Bacteria,1PXF4@1224|Proteobacteria,2TV0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD3_k127_6576334_0	1173026.Glo7428_1980	3.426e-150	486.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HFD3_k127_6576334_7	1173026.Glo7428_1817	1.712e-47	179.0	COG0730@1|root,COG0730@2|Bacteria,1G72I@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_6576334_4	1354722.JQLS01000005_gene3955	4.428e-99	339.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	cytC6	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EB_dh
HFD3_k127_6576334_8	1458427.BAWN01000012_gene707	3.728e-39	156.0	COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,2VU9J@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD3_k127_6576334_10	1340493.JNIF01000003_gene3147	1.941e-24	106.0	COG1695@1|root,COG1695@2|Bacteria,3Y5GY@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD3_k127_6607183_1	331869.BAL199_08893	1.485e-145	475.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,4BQ0U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HFD3_k127_6607183_2	351016.RAZWK3B_09876	7.012e-44	169.0	COG0537@1|root,COG1403@1|root,COG0537@2|Bacteria,COG1403@2|Bacteria,1N3EA@1224|Proteobacteria,2UN7N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT,HNH
HFD3_k127_6607183_0	485913.Krac_6173	1.608e-194	618.0	COG2079@1|root,COG2079@2|Bacteria,2G7JZ@200795|Chloroflexi	200795|Chloroflexi	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_6607183_4	1437882.AZRU01000003_gene1750	4.89e-08	56.0	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,1RZ73@1236|Gammaproteobacteria,1YENA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.22	ko:K18289	ko00660,map00660	-	R02407,R03154	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_transf_3
HFD3_k127_6607183_6	1121127.JAFA01000047_gene38	4.407e-05	50.0	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VKDA@28216|Betaproteobacteria,1JZU6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.22	ko:K18289	ko00660,map00660	-	R02407,R03154	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_transf_3
HFD3_k127_6607183_5	1157708.KB907450_gene6421	5.258e-07	52.0	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VKDA@28216|Betaproteobacteria,4AA04@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_6607183_3	713587.THITH_07545	7.687e-41	154.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,1X24R@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD3_k127_6622366_3	189753.AXAS01000041_gene2534	2.151e-70	250.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_6622366_0	868595.Desca_0602	3.945e-113	382.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,2605E@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM conserved	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
HFD3_k127_6622366_7	690585.JNNU01000008_gene3736	4.796e-16	90.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6622366_2	1379698.RBG1_1C00001G0892	1.434e-76	269.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
HFD3_k127_6622366_4	316067.Geob_3768	2.579e-59	216.0	COG4313@1|root,COG4313@2|Bacteria,1NW7I@1224|Proteobacteria,42ZUG@68525|delta/epsilon subdivisions,2WVAI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD3_k127_6622366_1	1343739.PAP_00255	3.72e-81	286.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,242MF@183968|Thermococci	183968|Thermococci	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD3_k127_6622366_8	591158.SSMG_01145	9.075e-11	69.0	COG0028@1|root,COG0028@2|Bacteria,2GMIJ@201174|Actinobacteria	201174|Actinobacteria	EH	phosphonopyruvate decarboxylase	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
HFD3_k127_6622366_6	648885.KB316283_gene2831	1.553e-36	149.0	COG0028@1|root,COG0028@2|Bacteria,1R610@1224|Proteobacteria,2U43S@28211|Alphaproteobacteria,1JWRR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HFD3_k127_6622366_5	1173263.Syn7502_03004	5.398e-51	196.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_6639249_2	706587.Desti_1914	1.959e-199	626.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MR3T@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
HFD3_k127_6639249_3	1232437.KL662077_gene1878	6.489e-78	267.0	COG1142@1|root,COG1142@2|Bacteria,1RBG7@1224|Proteobacteria,42R5G@68525|delta/epsilon subdivisions,2WMV5@28221|Deltaproteobacteria,2MJMU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K19516	ko00362,ko01100,ko01120,map00362,map01100,map01120	M00541	R10961	RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD3_k127_6639249_0	1232437.KL662077_gene1879	0.0	1039.0	COG2414@1|root,COG2414@2|Bacteria,1R9KF@1224|Proteobacteria,42PQB@68525|delta/epsilon subdivisions,2WKS3@28221|Deltaproteobacteria,2MPW2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HFD3_k127_6639249_1	671143.DAMO_1565	8.393e-275	861.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD3_k127_6647241_2	1116472.MGMO_175c00050	7.16e-22	96.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1XDWA@135618|Methylococcales	135618|Methylococcales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HFD3_k127_6647241_1	1121405.dsmv_0941	1.185e-81	282.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD3_k127_6647241_4	264732.Moth_1799	8.32e-16	80.0	arCOG07672@1|root,32Z5Y@2|Bacteria,1VG6R@1239|Firmicutes,24T0M@186801|Clostridia,42H3E@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4258)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
HFD3_k127_6647241_5	264732.Moth_1798	2.118e-09	62.0	2DR9H@1|root,33ASP@2|Bacteria,1VMWC@1239|Firmicutes,24V74@186801|Clostridia,42HF0@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6647241_3	1340493.JNIF01000003_gene4150	7.503e-17	94.0	COG1470@1|root,COG4625@1|root,COG1470@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	57723|Acidobacteria	M	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
HFD3_k127_6647241_0	1459636.NTE_01932	8.483e-110	376.0	COG2133@1|root,arCOG02796@2157|Archaea	1459636.NTE_01932|-	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	-
HFD3_k127_6647241_6	3659.XP_004144006.1	6.086e-06	52.0	COG1073@1|root,KOG4667@2759|Eukaryota,37JBE@33090|Viridiplantae,3GB8U@35493|Streptophyta,4JDX9@91835|fabids	35493|Streptophyta	I	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	BAAT_C,Hydrolase_4
HFD3_k127_6662781_4	1532558.JL39_00915	4.848e-21	99.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_6662781_1	1380394.JADL01000001_gene2929	2.801e-79	282.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_6662781_2	1002672.SAR11G3_00806	2.782e-74	267.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,4BQ0U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HFD3_k127_6662781_3	1231391.AMZF01000046_gene961	1.022e-43	174.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_6662781_0	369723.Strop_1584	1.066e-116	385.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DBUA@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HFD3_k127_6662781_5	1144343.PMI41_03244	2.666e-19	90.0	COG0500@1|root,COG0500@2|Bacteria,1NTKQ@1224|Proteobacteria,2UQGJ@28211|Alphaproteobacteria,43N8N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HFD3_k127_6692609_4	392499.Swit_1392	7.279e-10	67.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2KARB@204457|Sphingomonadales	204457|Sphingomonadales	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD3_k127_6692609_3	1274374.CBLK010000066_gene1525	1.323e-57	209.0	COG1335@1|root,COG1335@2|Bacteria,1VA32@1239|Firmicutes,4HKVT@91061|Bacilli,26XP2@186822|Paenibacillaceae	91061|Bacilli	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD3_k127_6692609_5	388401.RB2150_15625	9.836e-06	57.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,3ZH1B@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
HFD3_k127_6692609_0	1380394.JADL01000009_gene3144	4.322e-151	484.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,2JXDQ@204441|Rhodospirillales	204441|Rhodospirillales	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HFD3_k127_6692609_2	266117.Rxyl_0283	1.933e-87	297.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4CQ3S@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HFD3_k127_6692609_1	1192034.CAP_4624	6.957e-111	369.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PVS@68525|delta/epsilon subdivisions,2WJ7B@28221|Deltaproteobacteria,2YXQQ@29|Myxococcales	28221|Deltaproteobacteria	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HFD3_k127_6692609_6	426114.THI_0610	2.703e-05	46.0	COG3428@1|root,COG3428@2|Bacteria,1N9PB@1224|Proteobacteria,2W341@28216|Betaproteobacteria,1KP17@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HFD3_k127_6732829_10	1382356.JQMP01000004_gene231	1.17e-24	104.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia	189775|Thermomicrobia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HFD3_k127_6732829_8	926550.CLDAP_39560	1.674e-30	125.0	COG1975@1|root,COG1975@2|Bacteria	2|Bacteria	O	molybdopterin cofactor binding	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD3_k127_6732829_6	574087.Acear_0467	5.205e-46	175.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,3WBPN@53433|Halanaerobiales	186801|Clostridia	O	XdhC Rossmann domain	pucA	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HFD3_k127_6732829_12	76114.ebA3131	3.047e-19	92.0	COG1339@1|root,COG1339@2|Bacteria,1NFGP@1224|Proteobacteria,2W3D2@28216|Betaproteobacteria,2KZ1I@206389|Rhodocyclales	206389|Rhodocyclales	HK	Domain of unknown function DUF120	-	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase
HFD3_k127_6732829_4	571.MC52_28310	6.143e-73	252.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
HFD3_k127_6732829_1	1128421.JAGA01000003_gene3064	3.833e-109	364.0	COG1304@1|root,COG1304@2|Bacteria,2NQHB@2323|unclassified Bacteria	2|Bacteria	C	FMN-dependent dehydrogenase	fni	GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
HFD3_k127_6732829_7	76114.ebA3146	3.019e-40	154.0	COG3787@1|root,COG3787@2|Bacteria,1PV3C@1224|Proteobacteria,2WB2H@28216|Betaproteobacteria,2KYQQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K09979	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HFD3_k127_6732829_13	1121127.JAFA01000002_gene1700	1.66e-12	74.0	2DAI9@1|root,32TVI@2|Bacteria,1R3N0@1224|Proteobacteria,2WIIK@28216|Betaproteobacteria,1K90U@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD3_k127_6732829_2	443143.GM18_2043	1.885e-101	347.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HFD3_k127_6732829_3	671143.DAMO_3154	7.709e-92	311.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_6732829_0	338966.Ppro_3235	1.521e-133	437.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43THP@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HFD3_k127_6732829_11	414684.RC1_2914	2.277e-23	104.0	COG0346@1|root,COG0346@2|Bacteria,1RHZT@1224|Proteobacteria,2U9Z4@28211|Alphaproteobacteria,2JSYE@204441|Rhodospirillales	204441|Rhodospirillales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_2
HFD3_k127_6732829_5	247490.KSU1_C1131	7.461e-57	203.0	COG1881@1|root,COG1881@2|Bacteria,2J1MM@203682|Planctomycetes	203682|Planctomycetes	G	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP,YHYH
HFD3_k127_6732829_9	717606.PaecuDRAFT_1466	1.268e-29	129.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli,26T37@186822|Paenibacillaceae	91061|Bacilli	S	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HFD3_k127_6733354_3	316067.Geob_3768	6.907e-49	183.0	COG4313@1|root,COG4313@2|Bacteria,1NW7I@1224|Proteobacteria,42ZUG@68525|delta/epsilon subdivisions,2WVAI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD3_k127_6733354_7	234267.Acid_2805	1.016e-05	52.0	COG0017@1|root,COG0017@2|Bacteria,3Y350@57723|Acidobacteria	57723|Acidobacteria	J	PFAM tRNA synthetase, class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD3_k127_6733354_4	28072.Nos7524_5446	1.141e-33	133.0	COG3339@1|root,COG3339@2|Bacteria,1G7DF@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HFD3_k127_6733354_5	883080.HMPREF9697_02287	1.919e-24	109.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3JSVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_6733354_6	357804.Ping_2327	2.133e-16	87.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,2QJ72@267894|Psychromonadaceae	1236|Gammaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HFD3_k127_6733354_0	272134.KB731324_gene4530	2.595e-198	628.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HFD3_k127_6733354_2	768671.ThimaDRAFT_1696	6.039e-69	243.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1WYDE@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HFD3_k127_6733354_1	1000565.METUNv1_02912	2.275e-139	449.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,2KV6B@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HFD3_k127_6782848_0	357808.RoseRS_1931	5.888e-241	757.0	COG0366@1|root,COG0366@2|Bacteria,2G5NW@200795|Chloroflexi,377XK@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
HFD3_k127_6782848_1	189753.AXAS01000041_gene2534	2.342e-29	119.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_6782848_3	2045.KR76_02260	1.529e-13	81.0	COG0715@1|root,COG0715@2|Bacteria,2HFTV@201174|Actinobacteria,4DVZY@85009|Propionibacteriales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_6782848_2	443255.SCLAV_5312	2.197e-24	108.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_6791300_6	580327.Tthe_0925	5.625e-34	136.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,42FA6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_6791300_1	1449353.JQMQ01000005_gene1009	1.954e-79	274.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,2NFMA@228398|Streptacidiphilus	201174|Actinobacteria	J	tRNA methyltransferase complex GCD14 subunit N-term	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
HFD3_k127_6791300_0	1122915.AUGY01000005_gene5791	1.413e-84	292.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,26RHF@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_6791300_3	1122915.AUGY01000118_gene6542	1.183e-52	195.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4I4D7@91061|Bacilli,272RG@186822|Paenibacillaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_6791300_4	1173263.Syn7502_03006	7.621e-50	197.0	COG0600@1|root,COG0600@2|Bacteria,1G1ZK@1117|Cyanobacteria,1GZMV@1129|Synechococcus	1117|Cyanobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_6791300_7	1047013.AQSP01000138_gene1074	5.389e-20	94.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD3_k127_6791300_2	1231391.AMZF01000003_gene3115	1.535e-72	252.0	COG1028@1|root,COG1028@2|Bacteria,1N3A2@1224|Proteobacteria,2W95G@28216|Betaproteobacteria,3T7RQ@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD3_k127_6791300_5	1382359.JIAL01000001_gene2516	4.408e-37	141.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria,2JK6X@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HFD3_k127_679143_9	1429916.X566_02265	1.868e-15	78.0	COG0517@1|root,COG0517@2|Bacteria,1NMH1@1224|Proteobacteria,2U9D8@28211|Alphaproteobacteria,3JZSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD3_k127_679143_7	448385.sce9285	6.966e-32	128.0	COG3668@1|root,32ZH9@2|Bacteria,1N7YH@1224|Proteobacteria,43843@68525|delta/epsilon subdivisions,2X9WS@28221|Deltaproteobacteria,2YVMZ@29|Myxococcales	28221|Deltaproteobacteria	S	COG3668 Plasmid stabilization system protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_679143_4	1173027.Mic7113_2540	3.269e-103	340.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HFD3_k127_679143_5	1128421.JAGA01000004_gene2490	5.05e-88	299.0	COG4914@1|root,COG4914@2|Bacteria,2NR6N@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204,NTP_transf_5
HFD3_k127_679143_8	1460640.JCM19046_1292	2.757e-18	89.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,4HIXH@91061|Bacilli,1ZG9M@1386|Bacillus	91061|Bacilli	T	response regulator	spo0F	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD3_k127_679143_6	330214.NIDE3570	1.564e-82	306.0	COG2203@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
HFD3_k127_679143_3	671143.DAMO_0699	6.854e-170	544.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
HFD3_k127_679143_0	330214.NIDE3464	4.818e-311	964.0	COG0296@1|root,COG0296@2|Bacteria,3J0WY@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HFD3_k127_679143_2	1121430.JMLG01000001_gene2395	9.703e-232	733.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,261BK@186807|Peptococcaceae	186801|Clostridia	G	Domain of unknown function (DUF3459)	-	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
HFD3_k127_679143_1	247490.KSU1_B0323	1.064e-277	860.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HFD3_k127_6791843_3	1200792.AKYF01000012_gene1069	4.145e-59	211.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli,26URK@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HFD3_k127_6791843_4	330214.NIDE0277	1.336e-21	109.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
HFD3_k127_6791843_2	1415778.JQMM01000001_gene2119	2.33e-103	355.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD3_k127_6791843_1	671143.DAMO_0887	3.368e-121	407.0	COG2204@1|root,COG2204@2|Bacteria,2NQQY@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	FHA,GAF_3,HTH_8,Response_reg,Sigma54_activat
HFD3_k127_6791843_0	1380391.JIAS01000015_gene43	1.624e-191	622.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HFD3_k127_6791843_5	1521187.JPIM01000065_gene1265	6.824e-17	92.0	COG0457@1|root,COG0457@2|Bacteria	1521187.JPIM01000065_gene1265|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6810664_4	395961.Cyan7425_4631	4.275e-07	60.0	COG3577@1|root,COG3577@2|Bacteria,1G81F@1117|Cyanobacteria,3KHTG@43988|Cyanothece	1117|Cyanobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	Asp_protease_2,gag-asp_proteas
HFD3_k127_6810664_2	880073.Calab_2887	9.459e-81	284.0	COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_6810664_1	1232410.KI421426_gene1428	7.653e-125	415.0	COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,42PBF@68525|delta/epsilon subdivisions,2WJG0@28221|Deltaproteobacteria,43SA6@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HFD3_k127_6810664_5	76114.ebA4781	0.0002175	53.0	COG3087@1|root,COG3087@2|Bacteria,1QVC5@1224|Proteobacteria,2WGPN@28216|Betaproteobacteria,2KZVW@206389|Rhodocyclales	206389|Rhodocyclales	D	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
HFD3_k127_6810664_0	398512.JQKC01000004_gene5133	1.301e-184	590.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,3WGCT@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD3_k127_6810664_3	1071073.KI530536_gene1016	9.879e-22	94.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,4HBAZ@91061|Bacilli,1ZAT1@1386|Bacillus	91061|Bacilli	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD3_k127_6819072_2	1403819.BATR01000019_gene629	1.983e-80	301.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,46SBM@74201|Verrucomicrobia,2IV76@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HisKA_3,PAS_4
HFD3_k127_6819072_0	404589.Anae109_1061	8.408e-212	693.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria	1224|Proteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	2.1.1.80	ko:K00575,ko:K12266	ko02020,ko02030,ko05132,map02020,map02030,map05132	-	-	-	ko00000,ko00001,ko01000,ko02035,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS,PAS_3,PAS_4,PAS_9,Sigma54_activat
HFD3_k127_6819072_5	221288.JH992900_gene391	2.615e-07	54.0	COG2267@1|root,COG2267@2|Bacteria,1G000@1117|Cyanobacteria,1JMHA@1189|Stigonemataceae	1117|Cyanobacteria	I	Serine aminopeptidase, S33	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HFD3_k127_6819072_1	1366050.N234_30720	1.884e-181	571.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2W1R8@28216|Betaproteobacteria,1KGRA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.7	ko:K01502	ko00643,ko01120,map00643,map01120	-	R05358	RC01336	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD3_k127_6819072_4	1037409.BJ6T_58330	7.831e-16	81.0	COG3439@1|root,COG3439@2|Bacteria,1RBY0@1224|Proteobacteria,2U5Y0@28211|Alphaproteobacteria,3JYKW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HFD3_k127_6843514_4	1038860.AXAP01000063_gene2472	7.023e-19	90.0	COG0517@1|root,COG0517@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria,3JTNC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	BON domain	MA20_38110	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HFD3_k127_6843514_1	264732.Moth_0262	2.239e-143	461.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,42F8D@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HFD3_k127_6843514_0	309803.CTN_0395	3.964e-149	484.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HFD3_k127_6843514_2	880073.Calab_3404	1.088e-114	380.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667,ko:K07714	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_6843514_3	56780.SYN_00043	3.472e-99	342.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MQ5U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HFD3_k127_6891688_4	1157490.EL26_04985	7.125e-20	91.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4HASY@91061|Bacilli	91061|Bacilli	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HFD3_k127_6891688_0	1234664.AMRO01000019_gene754	1.318e-55	216.0	COG0584@1|root,COG3540@1|root,COG0584@2|Bacteria,COG3540@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1WHRB@129337|Geobacillus	91061|Bacilli	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.3.1,3.1.4.46	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	GDPD
HFD3_k127_6891688_3	1379698.RBG1_1C00001G0433	4.067e-33	136.0	COG0701@1|root,COG0701@2|Bacteria,2NQ4Q@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	MA20_06590	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HFD3_k127_6891688_1	1207058.L53_02870	6.001e-55	209.0	COG0624@1|root,COG0624@2|Bacteria,1MV5P@1224|Proteobacteria,2U0Z8@28211|Alphaproteobacteria,43ZHF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6891688_2	1121271.AUCM01000009_gene2235	2.39e-40	161.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6891688_6	1254432.SCE1572_35290	1.287e-09	59.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,43AB6@68525|delta/epsilon subdivisions,2X259@28221|Deltaproteobacteria,2YZEP@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_6912238_0	1038860.AXAP01000088_gene3680	1.283e-206	657.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,3JT9R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_6912238_1	706587.Desti_0822	9.775e-103	344.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_6912238_2	264198.Reut_B5778	1.887e-73	259.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6912782_1	335543.Sfum_1710	3.719e-31	141.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,2MQNV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HFD3_k127_6912782_2	318167.Sfri_2381	4.047e-19	100.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,2Q9HX@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HFD3_k127_6912782_0	335543.Sfum_0451	4.861e-209	666.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD3_k127_6994855_9	1232410.KI421413_gene566	1.899e-08	57.0	COG2184@1|root,COG2184@2|Bacteria,1QREW@1224|Proteobacteria,43B8J@68525|delta/epsilon subdivisions	1224|Proteobacteria	D	Fic/DOC family	fic	-	-	ko:K04095	-	-	-	-	ko00000,ko03036	-	-	-	Fic
HFD3_k127_6994855_10	338966.Ppro_1006	0.0005555	44.0	293J1@1|root,2ZR12@2|Bacteria,1P4CH@1224|Proteobacteria,4327B@68525|delta/epsilon subdivisions,2WYDD@28221|Deltaproteobacteria,43VQ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_6994855_8	1033802.SSPSH_002260	1.9e-10	62.0	2C8BN@1|root,32RKS@2|Bacteria,1N56Z@1224|Proteobacteria,1SDJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
HFD3_k127_6994855_1	330214.NIDE0999	7.43e-156	497.0	COG0059@1|root,COG0059@2|Bacteria,3J0DW@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HFD3_k127_6994855_6	1088869.GMO_21160	1.101e-50	186.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,2JR3J@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD3_k127_6994855_5	243231.GSU1907	6.245e-67	239.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,43SK7@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HFD3_k127_6994855_0	1125863.JAFN01000001_gene2479	3.485e-190	607.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HFD3_k127_6994855_3	1110502.TMO_3254	1.638e-136	443.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,2JPCN@204441|Rhodospirillales	204441|Rhodospirillales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD3_k127_6994855_2	1125863.JAFN01000001_gene96	5.074e-149	478.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD3_k127_6994855_4	1050202.KB913024_gene1928	3.967e-136	443.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,408CU@622450|Actinopolysporales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
HFD3_k127_6994855_7	1444712.BN1013_00079	4.458e-28	116.0	COG0101@1|root,COG0101@2|Bacteria,2JFJC@204428|Chlamydiae	204428|Chlamydiae	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA1	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HFD3_k127_6999204_0	243231.GSU3112	1.214e-198	640.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,43UK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD3_k127_6999204_3	264198.Reut_A2599	9.214e-18	92.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,1K3M9@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HFD3_k127_6999204_1	338963.Pcar_0034	9.365e-141	462.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,43S7N@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Uncharacterized protein family UPF0004	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HFD3_k127_6999204_2	404380.Gbem_0617	1.195e-25	112.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,42TPK@68525|delta/epsilon subdivisions,2X6N1@28221|Deltaproteobacteria,43UXV@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD3_k127_7002297_0	742821.HMPREF9464_00834	6.089e-199	637.0	COG1053@1|root,COG1053@2|Bacteria,1R0GR@1224|Proteobacteria,2WHU3@28216|Betaproteobacteria,4PRR9@995019|Sutterellaceae	28216|Betaproteobacteria	C	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_7002297_25	1174684.EBMC1_17152	8.979e-05	50.0	COG0346@1|root,COG0346@2|Bacteria,1N491@1224|Proteobacteria,2UK4T@28211|Alphaproteobacteria,2K9ZZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase-like domain	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	-
HFD3_k127_7002297_2	378806.STAUR_5664	8.052e-128	436.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_7002297_4	1168059.KB899087_gene2376	2.732e-101	339.0	COG0715@1|root,COG0715@2|Bacteria,1R4AB@1224|Proteobacteria,2U2A0@28211|Alphaproteobacteria,3F150@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7002297_5	1125973.JNLC01000010_gene1865	1.271e-95	319.0	COG0600@1|root,COG0600@2|Bacteria,1R546@1224|Proteobacteria,2TTRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_7002297_3	1297569.MESS2_90005	9.219e-108	356.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRXZ@28211|Alphaproteobacteria,43QYM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_7002297_7	1121033.AUCF01000006_gene4239	1.529e-83	284.0	COG0600@1|root,COG0600@2|Bacteria,1PH8M@1224|Proteobacteria,2V8ZI@28211|Alphaproteobacteria,2JXIM@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_7002297_13	305700.B447_02541	4.584e-64	233.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2VM18@28216|Betaproteobacteria,2KZHC@206389|Rhodocyclales	206389|Rhodocyclales	S	Pfam:AmoA	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
HFD3_k127_7002297_10	1297742.A176_04898	2.242e-78	270.0	COG0596@1|root,COG0596@2|Bacteria,1RFKC@1224|Proteobacteria,439ND@68525|delta/epsilon subdivisions,2X4ZP@28221|Deltaproteobacteria,2YZWF@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HFD3_k127_7002297_24	720554.Clocl_1041	1.985e-05	56.0	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,3WI60@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7002297_20	1205680.CAKO01000007_gene4346	6.128e-41	165.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,2JQCD@204441|Rhodospirillales	204441|Rhodospirillales	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_7002297_8	479434.Sthe_1499	6.746e-81	276.0	COG1116@1|root,COG1116@2|Bacteria,2GADK@200795|Chloroflexi,27Z50@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_7002297_18	1380355.JNIJ01000001_gene3897	2.773e-55	204.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VF1T@28211|Alphaproteobacteria,3JUMS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_7002297_1	591158.SSMG_03661	7.393e-161	531.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_7002297_23	1394178.AWOO02000014_gene7691	6.633e-19	100.0	COG0715@1|root,COG0715@2|Bacteria,2I172@201174|Actinobacteria,4EQFD@85012|Streptosporangiales	201174|Actinobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7002297_11	298653.Franean1_4523	1.299e-76	265.0	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_7002297_12	113395.AXAI01000002_gene5166	1.72e-72	253.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2TT6U@28211|Alphaproteobacteria,3JVFT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_7002297_6	46429.BV95_01791	1.591e-94	337.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TR3I@28211|Alphaproteobacteria,2K8XH@204457|Sphingomonadales	204457|Sphingomonadales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_7002297_15	1293048.CBMB010000004_gene2592	6.199e-60	223.0	COG0006@1|root,arCOG01000@2157|Archaea,2XVY0@28890|Euryarchaeota,23U8B@183963|Halobacteria	183963|Halobacteria	E	COG0006 Xaa-Pro aminopeptidase	pepB5	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_7002297_21	883078.HMPREF9695_00216	1.139e-38	157.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2TREQ@28211|Alphaproteobacteria,3JVU0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_7002297_9	484770.UFO1_2872	1.44e-79	273.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4H2GI@909932|Negativicutes	909932|Negativicutes	P	ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_7002297_19	1123288.SOV_4c07790	6.014e-44	171.0	COG0600@1|root,COG0600@2|Bacteria,1TQ26@1239|Firmicutes,4H2KK@909932|Negativicutes	909932|Negativicutes	P	membrane	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_7002297_14	1160707.AJIK01000010_gene2443	2.556e-61	221.0	COG0596@1|root,COG0596@2|Bacteria,1UISP@1239|Firmicutes,4HBGD@91061|Bacilli,26IDE@186818|Planococcaceae	91061|Bacilli	S	Alpha/beta hydrolase family	-	-	3.7.1.9	ko:K10216	ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R02604,R05362,R05865	RC00272,RC00753,RC00754,RC00755,RC01337,RC01485	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD3_k127_7002297_16	1231391.AMZF01000046_gene961	1.517e-57	213.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_7002297_22	1273538.G159_01735	1.47e-25	117.0	COG0596@1|root,COG0596@2|Bacteria,1UKJS@1239|Firmicutes,4ITJ3@91061|Bacilli,26EAB@186818|Planococcaceae	91061|Bacilli	S	Ndr family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD3_k127_7002297_17	583345.Mmol_1850	1.551e-57	211.0	2DNJJ@1|root,32XU7@2|Bacteria,1N0AU@1224|Proteobacteria,2VU15@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2971
HFD3_k127_7009670_19	1121875.KB907549_gene1996	8.34e-44	162.0	COG1063@1|root,COG1063@2|Bacteria,4P3W3@976|Bacteroidetes	976|Bacteroidetes	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HFD3_k127_7009670_15	1121918.ARWE01000001_gene3108	5.122e-68	237.0	COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria	1224|Proteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD3_k127_7009670_26	1121918.ARWE01000001_gene3108	2.044e-21	98.0	COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria	1224|Proteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD3_k127_7009670_30	5722.XP_001580800.1	2.389e-05	53.0	COG0366@1|root,2QRDK@2759|Eukaryota	2759|Eukaryota	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HFD3_k127_7009670_28	671143.DAMO_0132	5.384e-20	103.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
HFD3_k127_7009670_14	1265313.HRUBRA_01049	3.799e-73	256.0	COG2850@1|root,COG2850@2|Bacteria,1RDTN@1224|Proteobacteria,1SDPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
HFD3_k127_7009670_18	1537994.JQFW01000001_gene3530	9.128e-54	199.0	COG2267@1|root,COG2267@2|Bacteria,1R79U@1224|Proteobacteria,1S3DE@1236|Gammaproteobacteria,469I6@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	phaG	-	-	ko:K18100	ko02024,ko02025,map02024,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT1	-	Abhydrolase_1,Hydrolase_4
HFD3_k127_7009670_22	1547437.LL06_23330	9.738e-28	124.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,2TSVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HFD3_k127_7009670_24	1121875.KB907549_gene1997	1.438e-25	107.0	COG3408@1|root,COG3408@2|Bacteria,4PKJG@976|Bacteroidetes,1IJAW@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HFD3_k127_7009670_9	234267.Acid_2883	5.801e-159	507.0	COG3408@1|root,COG3408@2|Bacteria,3Y47W@57723|Acidobacteria	57723|Acidobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HFD3_k127_7009670_3	1267534.KB906754_gene3315	1.229e-257	803.0	COG3408@1|root,COG3408@2|Bacteria,3Y47W@57723|Acidobacteria,2JKGP@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HFD3_k127_7009670_7	1121875.KB907549_gene1996	1.124e-164	526.0	COG1063@1|root,COG1063@2|Bacteria,4P3W3@976|Bacteroidetes	976|Bacteroidetes	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HFD3_k127_7009670_11	1121918.ARWE01000001_gene3108	7.753e-100	331.0	COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria	1224|Proteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HFD3_k127_7009670_25	1040989.AWZU01000037_gene7320	2.342e-24	106.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JR6P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9
HFD3_k127_7009670_33	1380394.JADL01000013_gene761	0.0008741	42.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria	1224|Proteobacteria	G	alpha amylase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HFD3_k127_7009670_32	658655.HMPREF0988_01308	0.0002915	49.0	COG2267@1|root,COG2267@2|Bacteria,1TT75@1239|Firmicutes,25FMP@186801|Clostridia,27UGE@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HFD3_k127_7009670_0	1169143.KB911037_gene3943	0.0	1658.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HFD3_k127_7009670_4	1366050.N234_10420	2.154e-243	759.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,2VZQY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HFD3_k127_7009670_12	1476876.JOJO01000005_gene5111	4.446e-87	312.0	COG0561@1|root,COG0561@2|Bacteria,2IA5F@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HFD3_k127_7009670_8	196490.AUEZ01000002_gene4236	2.585e-162	533.0	COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,2U10P@28211|Alphaproteobacteria,3JWNC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HFD3_k127_7009670_27	1131553.JIBI01000012_gene827	7.484e-21	94.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2WC2A@28216|Betaproteobacteria,37479@32003|Nitrosomonadales	28216|Betaproteobacteria	GK	ROK family	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD3_k127_7009670_17	1229172.JQFA01000002_gene4544	1.633e-54	198.0	COG1940@1|root,COG1940@2|Bacteria,1G0YU@1117|Cyanobacteria,1H786@1150|Oscillatoriales	1117|Cyanobacteria	GK	Transcriptional regulator sugar kinase	ppgK	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HFD3_k127_7009670_2	1232410.KI421426_gene1491	5.341e-295	911.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,43S3J@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD3_k127_7009670_10	497964.CfE428DRAFT_5577	4.822e-132	427.0	COG3588@1|root,COG3588@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HFD3_k127_7009670_6	682795.AciX8_2885	2.466e-169	537.0	COG1023@1|root,COG1023@2|Bacteria,3Y2ZP@57723|Acidobacteria,2JJT6@204432|Acidobacteriia	204432|Acidobacteriia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HFD3_k127_7009670_5	1038860.AXAP01000029_gene681	6.434e-215	678.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2U0D0@28211|Alphaproteobacteria,3JURI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD3_k127_7009670_13	404589.Anae109_0599	1.967e-84	286.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HFD3_k127_7009670_16	886293.Sinac_2019	5.465e-56	203.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HFD3_k127_7009670_1	1267533.KB906745_gene56	0.0	1036.0	COG0021@1|root,COG0021@2|Bacteria,3Y38K@57723|Acidobacteria,2JHWX@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD3_k127_7009670_20	644282.Deba_2842	8.776e-33	132.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HFD3_k127_7009670_21	1500306.JQLA01000003_gene4503	1.009e-30	126.0	2E560@1|root,32ZYT@2|Bacteria,1RD6P@1224|Proteobacteria,2UJ9J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7009670_29	1379270.AUXF01000002_gene1568	7.588e-07	51.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
HFD3_k127_7012305_5	204669.Acid345_3895	2.253e-64	224.0	COG1629@1|root,COG1629@2|Bacteria,3Y99A@57723|Acidobacteria,2JP5H@204432|Acidobacteriia	204432|Acidobacteriia	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7012305_10	693661.Arcve_1526	3.988e-47	180.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,246MG@183980|Archaeoglobi	183980|Archaeoglobi	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD3_k127_7012305_0	1123368.AUIS01000032_gene1398	3.479e-217	694.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
HFD3_k127_7012305_4	1123368.AUIS01000032_gene1399	2.509e-68	250.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD3_k127_7012305_11	864069.MicloDRAFT_00017020	2.952e-16	81.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,1JSZK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CT	adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
HFD3_k127_7012305_1	204669.Acid345_0817	8.455e-110	367.0	COG0535@1|root,COG0535@2|Bacteria,3Y2KT@57723|Acidobacteria,2JIDX@204432|Acidobacteriia	204432|Acidobacteriia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HFD3_k127_7012305_9	518766.Rmar_1618	1.437e-47	181.0	COG0682@1|root,COG0682@2|Bacteria,4NGSG@976|Bacteroidetes	976|Bacteroidetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HFD3_k127_7012305_6	1499967.BAYZ01000171_gene5556	2.81e-53	190.0	COG1490@1|root,COG1490@2|Bacteria,2NPJK@2323|unclassified Bacteria	2|Bacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HFD3_k127_7012305_7	351627.Csac_1296	1.247e-52	189.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,42GF7@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HFD3_k127_7012305_8	592015.HMPREF1705_00292	2.396e-51	198.0	COG1470@1|root,COG1470@2|Bacteria,3TC52@508458|Synergistetes	508458|Synergistetes	S	PFAM NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
HFD3_k127_7012305_2	1121468.AUBR01000056_gene1488	4.478e-91	310.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,42ENV@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC transporter related	-	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
HFD3_k127_7012305_3	592015.HMPREF1705_00294	2.071e-76	266.0	COG1277@1|root,COG1277@2|Bacteria,3TC47@508458|Synergistetes	508458|Synergistetes	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HFD3_k127_7012305_12	1356854.N007_16800	9.947e-11	63.0	COG0043@1|root,COG0043@2|Bacteria	2|Bacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_701851_3	1278073.MYSTI_07192	5.777e-131	426.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2YWPA@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD3_k127_701851_7	247490.KSU1_D0349	3.799e-86	305.0	COG0457@1|root,COG0457@2|Bacteria,2IWTH@203682|Planctomycetes	203682|Planctomycetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_19
HFD3_k127_701851_11	247490.KSU1_D0350	2.146e-57	229.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_701851_4	1231391.AMZF01000063_gene1104	1.362e-125	421.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria	1224|Proteobacteria	E	ethanolamine utilization protein	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
HFD3_k127_701851_8	314278.NB231_14198	2.039e-72	249.0	COG0491@1|root,COG0491@2|Bacteria,1RGCD@1224|Proteobacteria,1S4WB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
HFD3_k127_701851_17	1128427.KB904821_gene2528	3.481e-09	67.0	COG0457@1|root,COG0457@2|Bacteria,1G39E@1117|Cyanobacteria,1H8XZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2,TPR_8
HFD3_k127_701851_18	1131269.AQVV01000011_gene2496	3.049e-05	54.0	COG1245@1|root,COG1245@2|Bacteria	2|Bacteria	C	4Fe-4S binding domain	rnfB	-	1.8.99.2	ko:K00395,ko:K02572,ko:K03616	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FeS,Fer4,Fer4_4,Fer4_7
HFD3_k127_701851_1	580331.Thit_1131	5.265e-175	560.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,42EY5@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Conserved carboxylase region	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HFD3_k127_701851_9	234267.Acid_2976	1.849e-64	233.0	COG0667@1|root,COG0667@2|Bacteria,3Y3TE@57723|Acidobacteria	57723|Acidobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_701851_13	1118054.CAGW01000061_gene2437	1.591e-52	192.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,4HFPC@91061|Bacilli,26X34@186822|Paenibacillaceae	91061|Bacilli	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	caiE	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HFD3_k127_701851_2	926569.ANT_17660	1.006e-150	486.0	COG0579@1|root,COG0579@2|Bacteria,2G67E@200795|Chloroflexi	200795|Chloroflexi	S	FAD dependent oxidoreductase	-	-	1.1.99.2	ko:K00109,ko:K15736	ko00650,map00650	-	R03534	RC00031	ko00000,ko00001,ko01000	-	-	-	DAO
HFD3_k127_701851_12	671143.DAMO_2217	1.055e-54	199.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD3_k127_701851_14	243231.GSU0815	3.132e-43	165.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD3_k127_701851_5	671143.DAMO_2220	1.038e-92	312.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	metN	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD3_k127_701851_6	330214.NIDE0863	1.654e-91	309.0	COG0767@1|root,COG0767@2|Bacteria,3J0I7@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD3_k127_701851_10	338963.Pcar_2227	4.195e-59	214.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,42SAA@68525|delta/epsilon subdivisions,2WPCM@28221|Deltaproteobacteria,43UIX@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM methyltransferase	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HFD3_k127_701851_15	338966.Ppro_1102	2.416e-18	93.0	COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria,42TK4@68525|delta/epsilon subdivisions,2WQQS@28221|Deltaproteobacteria,43VF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HFD3_k127_701851_0	483219.LILAB_22395	0.0	1197.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HFD3_k127_7025073_4	589865.DaAHT2_0551	2.966e-41	154.0	COG2191@1|root,COG2191@2|Bacteria,1RBNI@1224|Proteobacteria,42QZP@68525|delta/epsilon subdivisions,2WMY0@28221|Deltaproteobacteria,2MJH4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
HFD3_k127_7025073_6	237368.SCABRO_01075	3.922e-25	117.0	2AKTZ@1|root,31BM1@2|Bacteria,2J2UU@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7025073_5	247490.KSU1_B0259	1.925e-27	121.0	COG3381@1|root,COG3381@2|Bacteria,2J3EZ@203682|Planctomycetes	203682|Planctomycetes	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HFD3_k127_7025073_1	330214.NIDE3236	3.452e-193	610.0	COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ddhB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Fer4_11
HFD3_k127_7025073_0	247490.KSU1_B0257	0.0	1654.0	COG0243@1|root,COG0243@2|Bacteria,2J2QN@203682|Planctomycetes	203682|Planctomycetes	C	Molybdopterin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin
HFD3_k127_7025073_3	926550.CLDAP_18150	1.225e-42	175.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K17052	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
HFD3_k127_7025073_2	671143.DAMO_0779	5.383e-91	319.0	COG2010@1|root,COG2010@2|Bacteria,2NR8D@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD3_k127_7025073_7	518766.Rmar_2009	8.366e-14	75.0	COG1959@1|root,COG1959@2|Bacteria,4NURI@976|Bacteroidetes,1FJGW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD3_k127_7032898_2	675635.Psed_3034	1.195e-66	235.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_7032898_10	1005994.GTGU_00585	1.114e-05	53.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,1RMBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC transporter substrate-binding protein	afuA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_8
HFD3_k127_7032898_7	383372.Rcas_1470	4.982e-20	93.0	293XT@1|root,2ZRCU@2|Bacteria	2|Bacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HFD3_k127_7032898_3	425104.Ssed_1910	4.452e-61	220.0	COG0834@1|root,COG0834@2|Bacteria,1QCED@1224|Proteobacteria,1T84F@1236|Gammaproteobacteria,2QBTN@267890|Shewanellaceae	2|Bacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HFD3_k127_7032898_0	56780.SYN_01077	2.099e-156	528.0	COG0642@1|root,COG0745@1|root,COG3829@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG3829@2|Bacteria,1NWAF@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator, receiver	-	-	2.7.13.3	ko:K07677,ko:K07679,ko:K20974	ko02020,ko02025,ko02026,ko05133,map02020,map02025,map02026,map05133	M00474,M00477,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS_9,Response_reg
HFD3_k127_7032898_4	1079460.ATTQ01000014_gene2887	3.577e-47	174.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,4BFWW@82115|Rhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD3_k127_7032898_1	395495.Lcho_0045	1.584e-104	356.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1QY14@1224|Proteobacteria,2WH9F@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
HFD3_k127_7032898_5	314278.NB231_06775	6.182e-43	162.0	COG1017@1|root,COG1017@2|Bacteria,1NA56@1224|Proteobacteria,1SDRC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitric oxide dioxygenase activity	VPA1107	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7032898_9	1123242.JH636434_gene5202	5.945e-06	49.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HFD3_k127_7032898_8	351016.RAZWK3B_11036	8.303e-15	78.0	COG5016@1|root,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,2TXXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Conserved carboxylase domain	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like,PYC_OADA
HFD3_k127_7043105_1	1125863.JAFN01000001_gene2683	2.566e-95	319.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD3_k127_7043105_2	378806.STAUR_8341	1.814e-69	245.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,2YV3C@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD3_k127_7043105_0	926550.CLDAP_17420	5.32e-225	718.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HFD3_k127_7043105_5	1122915.AUGY01000118_gene6525	1.136e-26	122.0	COG0715@1|root,COG0715@2|Bacteria,1UZYY@1239|Firmicutes,4HE24@91061|Bacilli,26RHH@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_7043105_7	1042326.AZNV01000012_gene1948	1.56e-16	88.0	COG0235@1|root,COG0235@2|Bacteria,1RB5Z@1224|Proteobacteria,2U0PK@28211|Alphaproteobacteria,4BJMH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009111,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0030145,GO:0034641,GO:0042365,GO:0042737,GO:0042816,GO:0042820,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047431,GO:0071704,GO:0072524,GO:0072526,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	4.1.1.51	ko:K18613	ko00750,ko01120,map00750,map01120	-	R03461	RC00569	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HFD3_k127_7043105_8	1336208.JADY01000003_gene2813	6.756e-10	61.0	COG1278@1|root,COG1278@2|Bacteria,1Q07M@1224|Proteobacteria,2UV3T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD3_k127_7043105_3	1232410.KI421412_gene406	3.777e-63	231.0	COG1193@1|root,COG1193@2|Bacteria,1QYV7@1224|Proteobacteria	1224|Proteobacteria	L	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7043105_4	1231391.AMZF01000046_gene961	2.377e-52	198.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_7043105_6	497964.CfE428DRAFT_5221	8.906e-22	100.0	COG2402@1|root,COG2402@2|Bacteria,46WKX@74201|Verrucomicrobia	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD3_k127_7044730_3	316067.Geob_2599	7.745e-14	74.0	COG2982@1|root,COG2982@2|Bacteria,1PJZH@1224|Proteobacteria,42XG1@68525|delta/epsilon subdivisions,2WTDH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HFD3_k127_7044730_0	56780.SYN_02762	1.765e-81	286.0	COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N,YbbR
HFD3_k127_7044730_2	1158165.KB898872_gene986	9.243e-16	79.0	COG5487@1|root,COG5487@2|Bacteria,1NCF3@1224|Proteobacteria,1SCWG@1236|Gammaproteobacteria,1WZN9@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HFD3_k127_7044730_5	596151.DesfrDRAFT_1807	1.15e-09	60.0	2AEVA@1|root,314ST@2|Bacteria,1PUP4@1224|Proteobacteria,4369S@68525|delta/epsilon subdivisions,2X0UI@28221|Deltaproteobacteria,2MDFU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
HFD3_k127_7044730_1	1123274.KB899408_gene3882	1.667e-31	130.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HFD3_k127_7044730_4	443598.AUFA01000009_gene5623	5.273e-12	68.0	COG0517@1|root,COG0517@2|Bacteria,1Q3MP@1224|Proteobacteria,2UB19@28211|Alphaproteobacteria,3JY0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD3_k127_7050487_0	1523503.JPMY01000012_gene3182	1.914e-199	655.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,1RNG3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	membrane carboxypeptidase (Penicillin-binding protein)	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HFD3_k127_7050487_3	1305735.JAFT01000005_gene3805	1.609e-27	121.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HFD3_k127_7050487_8	77635.BISU_0816	1.186e-05	57.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,4CYWY@85004|Bifidobacteriales	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K15553	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.2	-	-	NMT1
HFD3_k127_7050487_2	262316.MAP_1627	1.588e-30	134.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,23625@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_7050487_6	908340.HMPREF9406_2195	1.848e-11	75.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7050487_5	1191523.MROS_2689	1.849e-14	77.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP,DegT_DnrJ_EryC1
HFD3_k127_7050487_1	1121381.JNIV01000052_gene3311	1.989e-102	341.0	COG2084@1|root,COG2084@2|Bacteria,1WKEB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD3_k127_7050487_7	1007105.PT7_2297	2.448e-11	68.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,3T5U4@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_7050487_4	340177.Cag_1786	1.156e-18	90.0	2BJMF@1|root,32DYT@2|Bacteria,1FF7D@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_706274_2	469383.Cwoe_4084	4.744e-182	575.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	2|Bacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_706274_0	469383.Cwoe_4085	6.26e-245	775.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_706274_1	469383.Cwoe_4085	2.803e-214	686.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HFD3_k127_706274_3	1134413.ANNK01000087_gene253	2.317e-171	549.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,1ZR0K@1386|Bacillus	91061|Bacilli	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_7066019_9	1278307.KB906999_gene13	3.726e-05	47.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,2QIGA@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD3_k127_7066019_6	221288.JH992901_gene3312	1.154e-20	95.0	2DNRM@1|root,32YT2@2|Bacteria,1G8M2@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HFD3_k127_7066019_7	1123257.AUFV01000019_gene2033	4.565e-11	68.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase,SLH
HFD3_k127_7066019_8	1123508.JH636439_gene1355	6.143e-11	70.0	COG0527@1|root,COG0527@2|Bacteria,2J3AJ@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7066019_2	526227.Mesil_1171	1.879e-45	173.0	COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD3_k127_7066019_5	330214.NIDE1052	1.211e-29	122.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD3_k127_7066019_3	1131269.AQVV01000006_gene471	2.804e-36	139.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
HFD3_k127_7066019_0	671143.DAMO_2787	3.207e-110	370.0	COG0301@1|root,COG0301@2|Bacteria,2NPBT@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
HFD3_k127_7066019_1	1547437.LL06_00335	3.258e-89	304.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,43IZ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_7066019_4	1047013.AQSP01000139_gene2341	5.441e-33	135.0	COG2068@1|root,COG2068@2|Bacteria,2NPK5@2323|unclassified Bacteria	2|Bacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	mocA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	HD,HTH_1,NTP_transf_3
HFD3_k127_7071885_24	935848.JAEN01000017_gene2323	7.774e-30	123.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2TT6U@28211|Alphaproteobacteria,2PWPE@265|Paracoccus	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HFD3_k127_7071885_5	945713.IALB_2363	1.455e-83	285.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD3_k127_7071885_29	1463857.JOFZ01000007_gene160	4.971e-23	111.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7071885_36	1547437.LL06_15655	1.933e-10	72.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7071885_15	330214.NIDE3956	2.402e-48	180.0	COG0424@1|root,COG0424@2|Bacteria	2|Bacteria	D	maF-like protein	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	2.1.1.190	ko:K03215,ko:K06287	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Maf
HFD3_k127_7071885_4	330214.NIDE3957	2.3e-110	368.0	COG0042@1|root,COG0042@2|Bacteria	2|Bacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05541	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HFD3_k127_7071885_35	1110502.TMO_0408	5.777e-12	79.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,2JR0Z@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
HFD3_k127_7071885_28	909663.KI867150_gene2324	1.71e-24	103.0	COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2MSAY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HFD3_k127_7071885_9	1379698.RBG1_1C00001G1513	5.787e-69	247.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD3_k127_7071885_30	247490.KSU1_C0797	3.234e-20	100.0	COG3642@1|root,COG3642@2|Bacteria	247490.KSU1_C0797|-	T	kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7071885_16	401526.TcarDRAFT_1317	6.057e-48	184.0	COG0859@1|root,COG0859@2|Bacteria,1TRN2@1239|Firmicutes,4H25K@909932|Negativicutes	909932|Negativicutes	M	lipopolysaccharide heptosyltransferase	rfaF	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HFD3_k127_7071885_26	247490.KSU1_D0289	3.597e-25	116.0	COG3642@1|root,COG3642@2|Bacteria	2|Bacteria	T	kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
HFD3_k127_7071885_11	459495.SPLC1_S140060	5.211e-56	206.0	COG1091@1|root,COG1091@2|Bacteria,1G3IE@1117|Cyanobacteria,1H8GQ@1150|Oscillatoriales	1117|Cyanobacteria	M	dTDP-4-dehydrorhamnose reductase	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HFD3_k127_7071885_31	314345.SPV1_01907	4.541e-19	96.0	COG0500@1|root,COG2226@2|Bacteria,1N1HA@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD3_k127_7071885_10	247490.KSU1_D0291	5.562e-61	225.0	COG0438@1|root,COG0438@2|Bacteria,2IZ1G@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_7071885_34	1123508.JH636439_gene1468	4.826e-16	89.0	COG0515@1|root,COG3642@1|root,COG0515@2|Bacteria,COG3642@2|Bacteria,2IZTN@203682|Planctomycetes	203682|Planctomycetes	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
HFD3_k127_7071885_2	760568.Desku_0716	1.403e-133	436.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia,25ZY9@186807|Peptococcaceae	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HFD3_k127_7071885_8	523845.AQXV01000055_gene144	9.641e-75	255.0	COG1898@1|root,arCOG04188@2157|Archaea,2XVIP@28890|Euryarchaeota,23RBN@183939|Methanococci	183939|Methanococci	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HFD3_k127_7071885_3	234267.Acid_6228	5.823e-115	380.0	COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HFD3_k127_7071885_19	207559.Dde_0844	2.36e-39	158.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria,2M88U@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_7071885_25	1229172.JQFA01000004_gene1865	2.054e-26	120.0	COG1216@1|root,COG1216@2|Bacteria,1G4BQ@1117|Cyanobacteria,1HAIH@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_7071885_20	370438.PTH_1074	1.736e-37	150.0	COG0500@1|root,COG2226@2|Bacteria,1VQC0@1239|Firmicutes,24VU0@186801|Clostridia,264PF@186807|Peptococcaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD3_k127_7071885_38	1131269.AQVV01000009_gene1155	0.0007966	51.0	2DM57@1|root,31S0Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7071885_6	247490.KSU1_D0287	6.905e-80	274.0	COG1216@1|root,COG1216@2|Bacteria,2IZV9@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_7071885_12	243233.MCA2126	2.662e-55	208.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RXGH@1236|Gammaproteobacteria,1XG2N@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
HFD3_k127_7071885_7	335543.Sfum_3634	7.473e-77	268.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2MQGF@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
HFD3_k127_7071885_17	866895.HBHAL_2906	1.625e-44	173.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,4HAK9@91061|Bacilli,3NDA8@45667|Halobacillus	91061|Bacilli	S	Domain of unknown function (DUF1732)	yloC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HFD3_k127_7071885_13	648996.Theam_1402	7.133e-51	195.0	COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae	200783|Aquificae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HFD3_k127_7071885_0	316067.Geob_2145	3.154e-268	844.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD3_k127_7071885_32	292459.STH1359	4.582e-18	85.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD3_k127_7071885_14	671143.DAMO_2535	2.192e-48	179.0	COG0615@1|root,COG0615@2|Bacteria,2NPMA@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	aut	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like
HFD3_k127_7071885_1	76114.p2A120	2.235e-162	524.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_7071885_27	96561.Dole_3056	8.27e-25	105.0	2E4RC@1|root,32ZJW@2|Bacteria,1N8RU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7071885_23	290315.Clim_0748	8.475e-32	131.0	COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi	1090|Chlorobi	M	PFAM OmpA MotB domain protein	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_7071885_18	1100720.ALKN01000052_gene507	9.644e-44	176.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_7071885_21	1499967.BAYZ01000157_gene585	4.151e-35	144.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
HFD3_k127_7071885_37	1120973.AQXL01000125_gene3114	0.0001671	49.0	COG2963@1|root,COG2963@2|Bacteria,1VPYW@1239|Firmicutes,4HZBX@91061|Bacilli	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HFD3_k127_7071885_22	1297865.APJD01000051_gene6887	1.252e-33	137.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JWTA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HFD3_k127_7080470_3	1303518.CCALI_01929	1.602e-07	61.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	CP_1111	GO:0005575,GO:0005576	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
HFD3_k127_7080470_2	1192034.CAP_6251	5.618e-46	180.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	1224|Proteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_7080470_1	1382356.JQMP01000003_gene1734	1.638e-64	233.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	4.1.1.55	ko:K04102	ko00624,ko01100,ko01120,map00624,map01100,map01120	M00623	R01635,R05375	RC00390	ko00000,ko00001,ko00002,ko01000	-	-	-	NMT1
HFD3_k127_7080470_0	243231.GSU3089	1.777e-90	313.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,43U19@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD3_k127_7102382_4	1265505.ATUG01000001_gene4162	1.168e-14	76.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2WK8E@28221|Deltaproteobacteria,2MITG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	4-hydroxybenzoate polyprenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD3_k127_7102382_0	401526.TcarDRAFT_1705	2.548e-195	622.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4H3EH@909932|Negativicutes	909932|Negativicutes	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_7102382_3	1123242.JH636435_gene1534	2.613e-90	321.0	COG0457@1|root,COG0457@2|Bacteria	1123242.JH636435_gene1534|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7102382_2	1123242.JH636435_gene1534	5.72e-97	343.0	COG0457@1|root,COG0457@2|Bacteria	1123242.JH636435_gene1534|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7102382_1	1123242.JH636435_gene1534	9.398e-98	336.0	COG0457@1|root,COG0457@2|Bacteria	1123242.JH636435_gene1534|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7117749_7	68570.DC74_1275	1.107e-41	164.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HFD3_k127_7117749_2	1121405.dsmv_2388	2.294e-93	312.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD3_k127_7117749_8	886293.Sinac_5575	1.657e-15	81.0	COG1512@1|root,COG3193@1|root,COG1512@2|Bacteria,COG3193@2|Bacteria,2IZVP@203682|Planctomycetes	203682|Planctomycetes	O	Haem-degrading	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HFD3_k127_7117749_1	1218173.BALCAV_0220995	8.554e-99	334.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,4HGBM@91061|Bacilli,1ZIHE@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD3_k127_7117749_5	330084.JNYZ01000044_gene2022	2.263e-65	227.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_7117749_3	1134413.ANNK01000144_gene3766	1.24e-72	255.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,4HGAZ@91061|Bacilli,1ZHAT@1386|Bacillus	91061|Bacilli	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_7117749_0	1408254.T458_21695	4.506e-295	926.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,26S7Z@186822|Paenibacillaceae	91061|Bacilli	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_7117749_6	760568.Desku_0629	3.297e-56	214.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,260E4@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_7117749_4	696369.KI912183_gene44	2.936e-67	241.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,260E4@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_713405_3	1128427.KB904821_gene494	8.185e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,Methyltransf_21,TPR_1,TPR_11,TPR_14,TPR_16,TPR_17,TPR_2,TPR_8
HFD3_k127_713405_0	446470.Snas_0537	2.84e-124	427.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Kelch_1,Kelch_3,Kelch_6
HFD3_k127_713405_2	1205680.CAKO01000038_gene1561	8.255e-13	72.0	COG1917@1|root,COG1917@2|Bacteria,1RKFY@1224|Proteobacteria,2UBGT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_713405_1	675635.Psed_3034	2.036e-114	387.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_7134985_5	1123368.AUIS01000024_gene953	4.76e-23	102.0	COG2890@1|root,COG2890@2|Bacteria,1MY5I@1224|Proteobacteria,1T26C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,PrmA
HFD3_k127_7134985_8	1121405.dsmv_2625	4.37e-06	58.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42UZS@68525|delta/epsilon subdivisions,2X77T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15551	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	NMT1,NMT1_2
HFD3_k127_7134985_7	196162.Noca_4459	1.75e-20	94.0	COG2128@1|root,COG2128@2|Bacteria,2HZX3@201174|Actinobacteria,4DUDY@85009|Propionibacteriales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7134985_3	196162.Noca_4459	2.472e-30	123.0	COG2128@1|root,COG2128@2|Bacteria,2HZX3@201174|Actinobacteria,4DUDY@85009|Propionibacteriales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7134985_2	319225.Plut_0616	2.757e-34	142.0	COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi	1090|Chlorobi	M	PFAM OmpA MotB domain protein	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD3_k127_7134985_6	485913.Krac_1828	1.035e-21	106.0	COG0596@1|root,COG0596@2|Bacteria,2G8Y9@200795|Chloroflexi	2|Bacteria	S	COGs COG0596 hydrolase or acyltransferase (alpha beta hydrolase superfamily)	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD3_k127_7134985_4	1231391.AMZF01000121_gene3473	3.756e-23	113.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_7134985_0	1502724.FF80_02474	1.319e-111	382.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_7134985_1	1463857.JOFZ01000002_gene4843	1.438e-82	286.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HFD3_k127_7153310_0	1173028.ANKO01000064_gene3082	0.0	1338.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Formyl_trans_N,Methyltransf_12,PP-binding,PilZ
HFD3_k127_7153310_2	402777.KB235898_gene5555	7.61e-37	147.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,PilZ
HFD3_k127_7153310_1	163908.KB235896_gene3710	1.771e-55	202.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_7153310_3	1337936.IJ00_07850	8.282e-29	121.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G3NP@1117|Cyanobacteria,1HIUE@1161|Nostocales	1117|Cyanobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding,Thioesterase
HFD3_k127_7153310_5	1047013.AQSP01000122_gene2229	3.161e-05	49.0	COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HFD3_k127_7153310_4	671143.DAMO_0218	2.535e-08	55.0	COG0677@1|root,COG0677@2|Bacteria,2NNQ1@2323|unclassified Bacteria	2|Bacteria	M	UDP binding domain	wbpA	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_7161392_4	312153.Pnuc_2050	1.398e-17	90.0	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2VV05@28216|Betaproteobacteria,1K1RQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HFD3_k127_7161392_5	326424.FRAAL5270	2.125e-16	89.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4EUGS@85013|Frankiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_7161392_2	1231391.AMZF01000046_gene961	9.904e-54	203.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_7161392_3	63737.Npun_F5723	1.057e-26	110.0	28JPA@1|root,2Z9FC@2|Bacteria,1G2DB@1117|Cyanobacteria,1HQP9@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7161392_1	1347392.CCEZ01000018_gene1136	1.609e-55	211.0	28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,36FG0@31979|Clostridiaceae	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits	grdE	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
HFD3_k127_7161392_0	891968.Anamo_0400	1.17e-108	361.0	COG1978@1|root,COG1978@2|Bacteria,3TA3Z@508458|Synergistetes	508458|Synergistetes	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HFD3_k127_7161392_6	457398.HMPREF0326_01686	2.929e-09	60.0	2DMKU@1|root,32S9Z@2|Bacteria,1QANK@1224|Proteobacteria,43696@68525|delta/epsilon subdivisions,2X0TS@28221|Deltaproteobacteria,2MDDS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Selenoprotein B glycine betaine sarcosine D-proline reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7161392_7	318424.EU78_08980	1.89e-06	50.0	COG0596@1|root,COG0596@2|Bacteria,2GMHK@201174|Actinobacteria,23DFJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_7169584_4	404589.Anae109_0271	2.364e-20	91.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD3_k127_7169584_2	517418.Ctha_2304	1.488e-74	257.0	COG1945@1|root,COG1945@2|Bacteria,1FDKS@1090|Chlorobi	1090|Chlorobi	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
HFD3_k127_7169584_3	457398.HMPREF0326_05777	3.601e-56	206.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2M9RT@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD3_k127_7169584_5	1232410.KI421420_gene3180	1.191e-17	85.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,43SSF@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	mttA/Hcf106 family	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD3_k127_7169584_6	1278307.KB907018_gene939	0.0003215	45.0	2DR6A@1|root,33ACN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7169584_0	350054.Mflv_3260	2.229e-194	634.0	COG2224@1|root,COG2224@2|Bacteria,2I926@201174|Actinobacteria,232A9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Isocitrate lyase	aceAb	GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HFD3_k127_7169584_1	909663.KI867150_gene472	9.15e-76	261.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MQC2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD3_k127_71745_1	269799.Gmet_0956	2.635e-157	509.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,43TAT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HFD3_k127_71745_3	1042163.BRLA_c001050	6.337e-84	287.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,4HB46@91061|Bacilli,26QFZ@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the NadC ModD family	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HFD3_k127_71745_4	338963.Pcar_1971	5.97e-67	237.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,43S1Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	HK	HTH domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HFD3_k127_71745_2	1278073.MYSTI_03801	1.236e-100	336.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2YTUR@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HFD3_k127_71745_0	1232410.KI421415_gene2955	4.579e-239	758.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,43RZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	elongation factor Tu domain 2 protein	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HFD3_k127_71745_8	706587.Desti_2842	2.243e-13	74.0	2EUYT@1|root,33NE0@2|Bacteria,1P79U@1224|Proteobacteria,432X2@68525|delta/epsilon subdivisions,2WXB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_71745_7	1160137.KB907307_gene1573	1.709e-15	88.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,4FZEY@85025|Nocardiaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_71745_5	1231391.AMZF01000003_gene3182	3.638e-49	188.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2WG6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_71745_6	886293.Sinac_2586	1.441e-36	148.0	COG0405@1|root,COG0405@2|Bacteria,2IY9Q@203682|Planctomycetes	203682|Planctomycetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD3_k127_7176414_2	1125973.JNLC01000010_gene1772	3.43e-75	261.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2VG8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HFD3_k127_7176414_1	1366050.N234_32655	6.685e-120	387.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,1JZYT@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HFD3_k127_7176414_5	883078.HMPREF9695_00532	0.0002488	47.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TT2P@28211|Alphaproteobacteria,3JWSW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD3_k127_7176414_3	1254432.SCE1572_07095	7.963e-37	152.0	28IX1@1|root,2Z8V3@2|Bacteria,1N0WD@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
HFD3_k127_7176414_0	644966.Tmar_1686	0.0	1184.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HFD3_k127_7194229_1	580332.Slit_2339	5.253e-87	291.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria,44WEU@713636|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM DNA-3-methyladenine glycosylase I	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HFD3_k127_7194229_3	1080067.BAZH01000014_gene437	2.32e-59	207.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_3
HFD3_k127_7194229_2	667632.KB890198_gene1151	8.881e-70	239.0	COG4101@1|root,COG4101@2|Bacteria,1RB8W@1224|Proteobacteria,2VPF8@28216|Betaproteobacteria,1K4JK@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_7194229_7	1144305.PMI02_00880	0.0009232	49.0	COG3473@1|root,COG3473@2|Bacteria,1RKZQ@1224|Proteobacteria,2U13U@28211|Alphaproteobacteria,2K85M@204457|Sphingomonadales	204457|Sphingomonadales	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD3_k127_7194229_0	266779.Meso_2926	6.772e-130	432.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_7194229_4	558169.AGAV01000018_gene3526	6.948e-41	166.0	COG3181@1|root,COG3181@2|Bacteria,1UY6C@1239|Firmicutes,4HERV@91061|Bacilli	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_7194229_5	247490.KSU1_C1261	6.841e-39	153.0	COG2854@1|root,COG2854@2|Bacteria,2J2VT@203682|Planctomycetes	203682|Planctomycetes	Q	MlaC protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaC
HFD3_k127_7194229_6	935863.AWZR01000013_gene1473	1.879e-27	113.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1X70R@135614|Xanthomonadales	135614|Xanthomonadales	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	dgkA	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
HFD3_k127_7200534_14	1459636.NTE_01706	1.476e-08	57.0	COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HFD3_k127_7200534_11	237368.SCABRO_03846	2.701e-49	183.0	COG3009@1|root,COG3009@2|Bacteria	2|Bacteria	Q	Protein conserved in bacteria	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HFD3_k127_7200534_5	338963.Pcar_2751	1.076e-80	282.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD3_k127_7200534_3	237368.SCABRO_03848	2.19e-104	344.0	COG1127@1|root,COG1127@2|Bacteria,2J2WI@203682|Planctomycetes	203682|Planctomycetes	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD3_k127_7200534_2	237368.SCABRO_03849	2.644e-122	404.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD3_k127_7200534_16	713586.KB900536_gene1661	4.265e-06	57.0	COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria,1X13M@135613|Chromatiales	135613|Chromatiales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_7200534_1	886293.Sinac_4912	8.215e-136	440.0	COG1533@1|root,COG1533@2|Bacteria,2IX0U@203682|Planctomycetes	203682|Planctomycetes	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD3_k127_7200534_15	644282.Deba_1223	4.409e-07	57.0	2ECCP@1|root,336AZ@2|Bacteria,1N9PN@1224|Proteobacteria,42W93@68525|delta/epsilon subdivisions,2WRXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
HFD3_k127_7200534_6	478741.JAFS01000001_gene1393	1.874e-78	275.0	COG0177@1|root,COG0177@2|Bacteria,46T2G@74201|Verrucomicrobia,37GJA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD3_k127_7200534_7	1282876.BAOK01000002_gene265	4.022e-62	222.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD3_k127_7200534_10	517418.Ctha_0772	9.262e-50	182.0	COG2839@1|root,COG2839@2|Bacteria,1FE53@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
HFD3_k127_7200534_0	883078.HMPREF9695_00951	3.809e-191	608.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_7200534_13	1205680.CAKO01000038_gene1807	8.501e-20	94.0	2EFUW@1|root,339M2@2|Bacteria,1R8JP@1224|Proteobacteria,2U5Q7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_23140	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HFD3_k127_7200534_8	398578.Daci_2876	1.451e-58	216.0	COG3181@1|root,COG3181@2|Bacteria,1N1ND@1224|Proteobacteria,2VKD0@28216|Betaproteobacteria,4ACWZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_7200534_9	32049.SYNPCC7002_A0337	4.192e-56	198.0	COG0346@1|root,COG0346@2|Bacteria,1G504@1117|Cyanobacteria,1H0G4@1129|Synechococcus	1117|Cyanobacteria	E	Lactoylglutathione lyase	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_7200534_4	1385519.N801_18235	3.072e-95	326.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320,ko:K14728	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD3_k127_7200534_12	547163.BN979_03362	1.328e-48	178.0	COG0402@1|root,COG0402@2|Bacteria,2IBR8@201174|Actinobacteria,2372F@1762|Mycobacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.18	ko:K15358	ko00760,ko01120,map00760,map01120	-	R07984	RC01933	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HFD3_k127_7238660_12	338963.Pcar_1921	5.789e-32	127.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,43S78@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S2	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD3_k127_7238660_4	1121428.DESHY_80112___1	3.443e-77	263.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HFD3_k127_7238660_3	316067.Geob_1520	1.295e-100	333.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,43SW0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD3_k127_7238660_8	706587.Desti_3975	7.241e-59	212.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MRJU@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD3_k127_7238660_5	439235.Dalk_3161	2.153e-76	264.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2MIZD@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD3_k127_7238660_11	1232410.KI421418_gene2267	1.107e-39	160.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2WQ6V@28221|Deltaproteobacteria,43SXU@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD3_k127_7238660_1	338966.Ppro_2050	4.939e-127	417.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria,43U18@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD3_k127_7238660_2	1121405.dsmv_2170	4.427e-104	349.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HFD3_k127_7238660_10	498761.HM1_1718	2.206e-42	164.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia	186801|Clostridia	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HFD3_k127_7238660_0	330214.NIDE0997	2.209e-272	848.0	COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae	40117|Nitrospirae	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_7238660_6	330214.NIDE0998	3.025e-69	238.0	COG0440@1|root,COG0440@2|Bacteria,3J0K8@40117|Nitrospirae	40117|Nitrospirae	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HFD3_k127_7238660_7	382464.ABSI01000017_gene13	5.207e-65	239.0	COG3008@1|root,COG3008@2|Bacteria,46V6H@74201|Verrucomicrobia,2ITG5@203494|Verrucomicrobiae	2|Bacteria	Q	MlaD protein	yebT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HFD3_k127_7238660_9	420662.Mpe_A0039	3.484e-44	168.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HFD3_k127_7238660_13	1232410.KI421412_gene435	3.101e-22	98.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,43TSZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HFD3_k127_724796_5	264462.Bd1701	1.332e-27	122.0	COG2227@1|root,COG2227@2|Bacteria,1QY24@1224|Proteobacteria,43C9E@68525|delta/epsilon subdivisions,2X7JV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_724796_2	314256.OG2516_16389	2.037e-40	162.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2U6AN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_724796_6	706587.Desti_0691	7.233e-05	49.0	COG1529@1|root,COG1529@2|Bacteria,1NPGE@1224|Proteobacteria	1224|Proteobacteria	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	MA20_13970	-	1.17.1.5	ko:K20448	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C2
HFD3_k127_724796_7	28072.Nos7524_1994	0.0001651	44.0	COG1529@1|root,COG1529@2|Bacteria,1G35M@1117|Cyanobacteria,1HISS@1161|Nostocales	1117|Cyanobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_724796_0	247490.KSU1_C0383	6.826e-181	574.0	COG4487@1|root,COG4487@2|Bacteria,2J16Y@203682|Planctomycetes	203682|Planctomycetes	I	mechanosensitive ion channel activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
HFD3_k127_724796_4	479434.Sthe_2174	5.628e-29	122.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_724796_3	479434.Sthe_2173	8.299e-33	137.0	COG0350@1|root,COG5662@1|root,COG0350@2|Bacteria,COG5662@2|Bacteria,2G98B@200795|Chloroflexi,27Z9T@189775|Thermomicrobia	2|Bacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	cseE	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	zf-HC2
HFD3_k127_724796_1	240016.ABIZ01000001_gene593	1.843e-67	239.0	COG0697@1|root,COG0697@2|Bacteria,46T3I@74201|Verrucomicrobia,2IVMP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_7254490_11	391625.PPSIR1_08911	3.081e-37	154.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HFD3_k127_7254490_15	595536.ADVE02000001_gene2899	6.699e-08	59.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,36YSC@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Glutaredoxin	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HFD3_k127_7254490_2	1259795.ARJK01000004_gene1341	9.118e-99	344.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42G7V@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K13274,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CW_binding_2,Peptidase_S8,SLH
HFD3_k127_7254490_12	765911.Thivi_0729	2.27e-24	104.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1WZFE@135613|Chromatiales	135613|Chromatiales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HFD3_k127_7254490_9	1382304.JNIL01000001_gene1586	2.818e-47	176.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,279RN@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
HFD3_k127_7254490_6	234267.Acid_3676	1.816e-59	211.0	COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria	57723|Acidobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD3_k127_7254490_1	344747.PM8797T_15421	1.111e-162	522.0	COG0334@1|root,COG0334@2|Bacteria,2IWWC@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	-	-	-	-	-	-	-	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD3_k127_7254490_10	697281.Mahau_0719	5.891e-44	163.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,42GH7@68295|Thermoanaerobacterales	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HFD3_k127_7254490_13	1122134.KB893650_gene50	3.621e-23	103.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,1SD0G@1236|Gammaproteobacteria,1XM3X@135619|Oceanospirillales	135619|Oceanospirillales	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD3_k127_7254490_14	570967.JMLV01000009_gene989	2.057e-19	94.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2UFDN@28211|Alphaproteobacteria,2JTWK@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD3_k127_7254490_7	156889.Mmc1_3283	2.545e-58	212.0	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD3_k127_7254490_4	269799.Gmet_2374	2.973e-74	254.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,42TFN@68525|delta/epsilon subdivisions,2WP7M@28221|Deltaproteobacteria,43SNC@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HFD3_k127_7254490_8	321327.CYA_1203	4.352e-52	192.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1H0H2@1129|Synechococcus	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
HFD3_k127_7254490_3	671143.DAMO_1459	5.358e-93	311.0	COG1215@1|root,COG1215@2|Bacteria,2NPIY@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_7254490_5	469383.Cwoe_5826	5.49e-72	251.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HFD3_k127_7254490_0	237368.SCABRO_00651	5.097e-200	637.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
HFD3_k127_7256939_19	795359.TOPB45_0960	2.549e-28	119.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GHPG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD3_k127_7256939_13	350058.Mvan_0472	3.046e-58	217.0	COG0329@1|root,COG0329@2|Bacteria,2HN4J@201174|Actinobacteria,23EW4@1762|Mycobacteriaceae	201174|Actinobacteria	EM	PFAM Dihydrodipicolinate synthetase	-	-	4.1.2.34	ko:K11946,ko:K11949	ko00624,ko01100,ko01120,ko01220,map00624,map01100,map01120,map01220	-	R05648,R07713	RC00924,RC00936	ko00000,ko00001,ko01000	-	-	-	DHDPS
HFD3_k127_7256939_15	118166.JH976538_gene5292	5.938e-46	177.0	COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,1HBYM@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD3_k127_7256939_11	401053.AciPR4_2842	3.187e-74	271.0	COG1807@1|root,COG1807@2|Bacteria,3Y2T0@57723|Acidobacteria,2JIGT@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7256939_17	909663.KI867151_gene3116	1.625e-40	173.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,42WPS@68525|delta/epsilon subdivisions,2WS8D@28221|Deltaproteobacteria,2MS9Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HFD3_k127_7256939_21	589865.DaAHT2_2283	1.163e-13	77.0	COG4969@1|root,COG4969@2|Bacteria,1QV9X@1224|Proteobacteria,42W4E@68525|delta/epsilon subdivisions,2X70G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD3_k127_7256939_9	1123371.ATXH01000011_gene71	1.652e-96	341.0	COG2204@1|root,COG2204@2|Bacteria,2GH79@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_7256939_6	1121918.ARWE01000001_gene1839	3.424e-143	464.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,43RZ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HFD3_k127_7256939_3	706587.Desti_3124	2.456e-208	662.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MQ93@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
HFD3_k127_7256939_0	945713.IALB_0341	0.0	1198.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HFD3_k127_7256939_18	56780.SYN_01535	3.266e-34	141.0	COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2MQM5@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HFD3_k127_7256939_16	338963.Pcar_0108	8.598e-44	167.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,43US5@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	GrpE	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD3_k127_7256939_2	1232410.KI421424_gene1722	1.12e-303	941.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,43TCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD3_k127_7256939_5	1232410.KI421424_gene1723	1.036e-152	491.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	DnaJ central domain	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD3_k127_7256939_1	338966.Ppro_2604	1.142e-317	992.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,43T3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD3_k127_7256939_12	269799.Gmet_3213	6.339e-70	248.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,43UHS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD3_k127_7256939_10	443143.GM18_4083	1.083e-91	308.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HFD3_k127_7256939_20	247490.KSU1_C0335	1.531e-24	109.0	COG1371@1|root,COG1371@2|Bacteria,2J0RY@203682|Planctomycetes	203682|Planctomycetes	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HFD3_k127_7256939_4	330214.NIDE3049	7.362e-172	551.0	COG1078@1|root,COG1078@2|Bacteria,3J0YB@40117|Nitrospirae	40117|Nitrospirae	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HFD3_k127_7256939_7	671143.DAMO_0051	6.396e-114	384.0	COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HFD3_k127_7256939_14	330214.NIDE4313	9.084e-57	204.0	COG0279@1|root,COG0279@2|Bacteria,3J0HG@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HFD3_k127_7256939_8	330214.NIDE4314	1.094e-103	344.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7259106_2	383372.Rcas_2148	2.755e-48	184.0	COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg
HFD3_k127_7259106_0	1125863.JAFN01000001_gene1446	6.435e-128	423.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_7259106_1	671143.DAMO_1116	7.001e-71	252.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_7289670_17	743299.Acife_3224	5.059e-18	90.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RMWW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
HFD3_k127_7289670_22	1458357.BG58_38300	2.118e-08	64.0	COG0500@1|root,COG2226@2|Bacteria,1NNRW@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HFD3_k127_7289670_29	875328.JDM601_1348	0.0006574	46.0	COG4974@1|root,COG4974@2|Bacteria,2HD2H@201174|Actinobacteria,236P7@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HFD3_k127_7289670_18	177437.HRM2_48070	5.197e-16	82.0	COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42T3Q@68525|delta/epsilon subdivisions,2WPUB@28221|Deltaproteobacteria,2MKDP@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HFD3_k127_7289670_3	177437.HRM2_05740	2.53e-102	351.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WMD3@28221|Deltaproteobacteria,2MMTW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
HFD3_k127_7289670_1	237368.SCABRO_02014	7.318e-132	435.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_7289670_20	1120971.AUCA01000001_gene1775	1.498e-12	79.0	COG4191@1|root,COG4191@2|Bacteria,1UWRB@1239|Firmicutes	1239|Firmicutes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HFD3_k127_7289670_26	56110.Oscil6304_3402	9.891e-05	54.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3437@1|root,COG4251@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71C@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD3_k127_7289670_13	397945.Aave_3049	6.654e-28	128.0	COG0477@1|root,COG2814@2|Bacteria,1R8QG@1224|Proteobacteria,2VIBD@28216|Betaproteobacteria,4ABIS@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_7289670_25	443152.MDG893_15447	4.892e-05	54.0	COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,1SM1X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	4,5-dihydroxyphthalate decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7289670_6	246196.MSMEI_2053	3.04e-53	203.0	COG0624@1|root,COG0624@2|Bacteria,2I9Y6@201174|Actinobacteria,23ER8@1762|Mycobacteriaceae	201174|Actinobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD3_k127_7289670_27	335543.Sfum_1279	0.0003307	53.0	COG5663@1|root,COG5663@2|Bacteria,1MZTH@1224|Proteobacteria,42TWZ@68525|delta/epsilon subdivisions,2WQEQ@28221|Deltaproteobacteria,2MRXZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
HFD3_k127_7289670_5	198467.NP92_06780	2.074e-59	214.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,21W76@150247|Anoxybacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
HFD3_k127_7289670_8	70601.3257399	7.788e-48	180.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	28890|Euryarchaeota	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_7289670_4	909663.KI867149_gene3384	3.163e-68	239.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
HFD3_k127_7289670_14	690850.Desaf_0463	3.149e-26	112.0	COG0457@1|root,COG0457@2|Bacteria	690850.Desaf_0463|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7289670_9	1183438.GKIL_3041	7.329e-41	154.0	COG0278@1|root,COG0278@2|Bacteria,1G6JA@1117|Cyanobacteria	1117|Cyanobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	ycf64	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
HFD3_k127_7289670_16	1173026.Glo7428_3250	1.433e-23	102.0	COG0271@1|root,COG0271@2|Bacteria,1G7V3@1117|Cyanobacteria	1117|Cyanobacteria	T	Belongs to the BolA IbaG family	colA	-	-	-	-	-	-	-	-	-	-	-	BolA
HFD3_k127_7289670_12	221288.JH992901_gene5641	3.234e-31	126.0	COG1225@1|root,COG1278@1|root,COG1225@2|Bacteria,COG1278@2|Bacteria,1GB7U@1117|Cyanobacteria,1JK51@1189|Stigonemataceae	1117|Cyanobacteria	KO	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	AhpC-TSA,CSD
HFD3_k127_7289670_28	287986.DV20_41475	0.0003359	49.0	COG1225@1|root,COG1225@2|Bacteria,2H4Y3@201174|Actinobacteria,4E5X8@85010|Pseudonocardiales	201174|Actinobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD3_k127_7289670_21	880073.Calab_3673	4.356e-10	64.0	COG3385@1|root,COG3385@2|Bacteria,2NRCF@2323|unclassified Bacteria	2|Bacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
HFD3_k127_7289670_15	1150399.AQYK01000002_gene3101	7.892e-24	108.0	2DB8V@1|root,2Z7SX@2|Bacteria,2IA72@201174|Actinobacteria,4FS8R@85023|Microbacteriaceae	201174|Actinobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HFD3_k127_7289670_0	566466.NOR53_631	1.155e-144	477.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HFD3_k127_7289670_10	379066.GAU_2184	3.176e-38	149.0	COG1670@1|root,COG1670@2|Bacteria,1ZUYQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD3_k127_7289670_11	1038860.AXAP01000097_gene5007	2.336e-37	153.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,3K1ZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_7289670_7	68219.JNXI01000032_gene7021	1.181e-48	181.0	COG1018@1|root,COG1018@2|Bacteria,2IN34@201174|Actinobacteria	201174|Actinobacteria	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7289670_30	333138.LQ50_24485	0.0008132	49.0	29RUP@1|root,30CYP@2|Bacteria,1UAJX@1239|Firmicutes,4IKYH@91061|Bacilli,1ZICV@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7289670_2	1265505.ATUG01000002_gene1927	9.401e-131	426.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,42RTY@68525|delta/epsilon subdivisions,2WNFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HFD3_k127_7289670_19	1163407.UU7_10740	9.758e-16	81.0	2CDT8@1|root,33C3R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7289670_23	1122915.AUGY01000118_gene6526	8.862e-08	59.0	COG0715@1|root,COG0715@2|Bacteria,1UZYY@1239|Firmicutes,4HE24@91061|Bacilli,26RHH@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_7311561_2	639283.Snov_0200	2.79e-75	265.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3F1EG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HFD3_k127_7311561_1	401526.TcarDRAFT_2037	2.207e-81	283.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4H3E1@909932|Negativicutes	909932|Negativicutes	Q	FAH family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_7311561_4	404589.Anae109_1268	1.361e-56	208.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2Z304@29|Myxococcales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HFD3_k127_7311561_5	1452718.JBOY01000046_gene1044	1.168e-14	76.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HFD3_k127_7311561_0	330214.NIDE3060	2.836e-118	387.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HFD3_k127_7311561_3	269799.Gmet_2935	6.751e-65	228.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WQME@28221|Deltaproteobacteria,43UPN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	tenI	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD3_k127_7324585_0	671143.DAMO_2494	3.469e-240	763.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD3_k127_7324585_1	671143.DAMO_2495	1.106e-197	635.0	COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	mdlA	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD3_k127_7324585_2	632518.Calow_1188	5.085e-191	610.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,42F4M@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HFD3_k127_7324585_8	330214.NIDE0490	1.655e-88	301.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HFD3_k127_7324585_6	56780.SYN_02161	2.947e-108	358.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2MR4I@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_7324585_9	67275.JOAP01000019_gene1228	1.923e-08	65.0	COG0308@1|root,COG0308@2|Bacteria,2GK29@201174|Actinobacteria	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7324585_7	289376.THEYE_A1134	1.938e-99	334.0	COG0253@1|root,COG0253@2|Bacteria,3J0JV@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD3_k127_7324585_4	338963.Pcar_2420	5.151e-172	549.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,43U09@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD3_k127_7324585_10	1499967.BAYZ01000105_gene3496	5.854e-06	55.0	COG4733@1|root,COG4733@2|Bacteria,2NQ62@2323|unclassified Bacteria	2|Bacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Cellulase,Dockerin_1,Flg_new,Laminin_G_3,Phage-tail_3
HFD3_k127_7324585_5	338963.Pcar_2418	3.339e-169	544.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,43RY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
HFD3_k127_7324585_3	1123376.AUIU01000014_gene702	6.728e-181	572.0	COG0137@1|root,COG0137@2|Bacteria,3J0BU@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HFD3_k127_7359184_1	65497.JODV01000009_gene2736	1.51e-94	328.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXK8@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	lcfB	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_7359184_4	1040989.AWZU01000001_gene5506	1.26e-05	57.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,3JSAQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7359184_3	1173263.Syn7502_03004	6.051e-38	156.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7359184_0	266779.Meso_2926	4.029e-143	468.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_7359184_2	706587.Desti_2244	1.244e-67	239.0	COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,42YBR@68525|delta/epsilon subdivisions,2WU33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HFD3_k127_7370815_7	381666.PHG283	1.163e-15	77.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HFD3_k127_7370815_10	1267005.KB911255_gene2382	7.45e-06	54.0	2DW4I@1|root,32V0S@2|Bacteria,1N219@1224|Proteobacteria,2UDSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7370815_2	909613.UO65_0943	3.583e-57	206.0	COG0664@1|root,COG0664@2|Bacteria,2INMI@201174|Actinobacteria,4EBXN@85010|Pseudonocardiales	201174|Actinobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD3_k127_7370815_8	443144.GM21_0541	1.037e-08	59.0	28T91@1|root,2ZFHN@2|Bacteria,1P659@1224|Proteobacteria,433I9@68525|delta/epsilon subdivisions,2WX6G@28221|Deltaproteobacteria,43VY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7370815_9	349102.Rsph17025_0493	1.832e-08	56.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,1FD12@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD3_k127_7370815_4	481448.Minf_0575	1.744e-26	114.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
HFD3_k127_7370815_3	671143.DAMO_2217	2.971e-30	127.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HFD3_k127_7370815_1	1125973.JNLC01000010_gene1772	4.558e-79	277.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2VG8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HFD3_k127_7370815_6	1380387.JADM01000007_gene509	9.97e-21	106.0	COG2358@1|root,COG2358@2|Bacteria,1R3ZR@1224|Proteobacteria,1SZVZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD3_k127_7370815_0	580340.Tlie_1710	1.966e-142	476.0	COG4666@1|root,COG4666@2|Bacteria,3TBZ1@508458|Synergistetes	508458|Synergistetes	S	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_7370815_5	935840.JAEQ01000004_gene646	9.569e-23	107.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7386676_7	1172188.KB911822_gene708	4.928e-18	85.0	COG0745@1|root,COG0745@2|Bacteria,2IS52@201174|Actinobacteria,4FH4M@85021|Intrasporangiaceae	201174|Actinobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD3_k127_7386676_1	1121396.KB892913_gene116	6.066e-119	394.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transposase zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HFD3_k127_7386676_3	384765.SIAM614_00642	3.14e-69	244.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HFD3_k127_7386676_6	706587.Desti_0054	6.82e-20	94.0	COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria,2MS60@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HFD3_k127_7386676_2	1121468.AUBR01000012_gene2583	1.652e-69	244.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,42FAI@68295|Thermoanaerobacterales	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HFD3_k127_7386676_0	215803.DB30_3033	2.416e-129	424.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2YTW5@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HFD3_k127_7386676_4	1232410.KI421422_gene2007	2.336e-67	242.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,43S1A@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HFD3_k127_7386676_5	243231.GSU0027	2.99e-36	142.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,43UY9@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HFD3_k127_7440955_20	1118054.CAGW01000075_gene3261	9.816e-26	119.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7440955_18	935840.JAEQ01000004_gene646	9.362e-32	136.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7440955_9	1054213.HMPREF9946_02869	2.609e-76	265.0	COG0596@1|root,COG0596@2|Bacteria,1P092@1224|Proteobacteria,2UV5T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD3_k127_7440955_3	1232410.KI421414_gene2901	7.367e-147	484.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,43T6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD3_k127_7440955_8	335543.Sfum_1920	1.862e-92	313.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MQEE@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD3_k127_7440955_2	234267.Acid_3699	9.779e-148	484.0	COG2355@1|root,COG2355@2|Bacteria,3Y7FK@57723|Acidobacteria	57723|Acidobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD3_k127_7440955_7	32057.KB217478_gene2914	6.845e-113	379.0	COG0523@1|root,COG0523@2|Bacteria,1G1BG@1117|Cyanobacteria,1HKYR@1161|Nostocales	1117|Cyanobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HFD3_k127_7440955_13	1259795.ARJK01000002_gene414	1.173e-57	210.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,42GNP@68295|Thermoanaerobacterales	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG4	-	1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76	ko:K00059,ko:K18009,ko:K19548	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R10917,R11671	RC00029,RC00117,RC00154,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD3_k127_7440955_17	1173263.Syn7502_03004	1.847e-39	160.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7440955_12	483219.LILAB_16360	7.89e-65	228.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,43BAG@68525|delta/epsilon subdivisions,2X6PP@28221|Deltaproteobacteria,2YUZG@29|Myxococcales	28221|Deltaproteobacteria	H	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HFD3_k127_7440955_16	1385515.N791_05640	6.12e-48	183.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1X407@135614|Xanthomonadales	135614|Xanthomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD3_k127_7440955_6	398767.Glov_2150	7.168e-117	389.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HFD3_k127_7440955_5	880072.Desac_0022	2.465e-119	395.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MR8N@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_7440955_10	338966.Ppro_1346	5.089e-75	261.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2WRNN@28221|Deltaproteobacteria,43TA8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HFD3_k127_7440955_4	398767.Glov_2148	3.935e-140	458.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,43TXZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HFD3_k127_7440955_14	697281.Mahau_1600	1.783e-57	207.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,42GBW@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD3_k127_7440955_0	1232410.KI421418_gene2309	2.169e-210	668.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,43RZS@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD3_k127_7440955_11	1232410.KI421418_gene2310	3.233e-74	259.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,43S2J@69541|Desulfuromonadales	28221|Deltaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD3_k127_7440955_19	652103.Rpdx1_0068	1.5e-27	115.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,3JZPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD3_k127_7440955_15	1163730.FFONT_0979	3.904e-49	182.0	COG0537@1|root,arCOG00419@2157|Archaea,2XQK8@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HFD3_k127_7440955_1	1382306.JNIM01000001_gene1826	1.811e-157	506.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi	200795|Chloroflexi	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
HFD3_k127_7451302_2	404589.Anae109_3135	2.125e-102	342.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HFD3_k127_7451302_5	1279017.AQYJ01000029_gene3723	2.494e-48	177.0	COG1917@1|root,COG1917@2|Bacteria,1R5IE@1224|Proteobacteria,1S3I4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_7451302_12	573370.DMR_04550	3.07e-14	76.0	COG1598@1|root,COG1598@2|Bacteria,1RIRX@1224|Proteobacteria,42W3D@68525|delta/epsilon subdivisions,2WRPE@28221|Deltaproteobacteria,2MC8P@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD3_k127_7451302_10	272123.Anacy_2755	1.178e-19	91.0	COG1724@1|root,COG1724@2|Bacteria,1GI62@1117|Cyanobacteria,1HT1T@1161|Nostocales	1117|Cyanobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HFD3_k127_7451302_3	436308.Nmar_1072	2.715e-72	264.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_7451302_7	1297742.A176_01323	2.47e-38	147.0	COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_7451302_0	671143.DAMO_2489	4.243e-172	556.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HFD3_k127_7451302_1	472759.Nhal_0440	6.308e-103	348.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WWYV@135613|Chromatiales	135613|Chromatiales	NU	Type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HFD3_k127_7451302_4	555779.Dthio_PD2708	8.372e-51	185.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MCQM@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HFD3_k127_7451302_11	765914.ThisiDRAFT_0680	1.044e-14	83.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	general secretion pathway protein	xpsH	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
HFD3_k127_7451302_14	1500893.JQNB01000001_gene608	3.357e-10	66.0	COG2165@1|root,COG2165@2|Bacteria,1NIHW@1224|Proteobacteria,1SE3Y@1236|Gammaproteobacteria,1X7PX@135614|Xanthomonadales	135614|Xanthomonadales	NU	General secretion pathway protein	xpsI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HFD3_k127_7451302_13	177437.HRM2_30160	1.515e-11	74.0	COG4966@1|root,COG4966@2|Bacteria,1QEE6@1224|Proteobacteria,433H9@68525|delta/epsilon subdivisions,2WY1D@28221|Deltaproteobacteria,2MPCI@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	-
HFD3_k127_7451302_6	933262.AXAM01000042_gene1817	7.612e-45	177.0	COG1555@1|root,COG3156@1|root,COG1555@2|Bacteria,COG3156@2|Bacteria,1PQMW@1224|Proteobacteria,42T9B@68525|delta/epsilon subdivisions,2WPYT@28221|Deltaproteobacteria,2MKAN@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HFD3_k127_7451302_8	933262.AXAM01000042_gene1818	7.472e-33	146.0	COG3166@1|root,COG4972@1|root,COG3166@2|Bacteria,COG4972@2|Bacteria,1PD1G@1224|Proteobacteria,42UEP@68525|delta/epsilon subdivisions,2WR1V@28221|Deltaproteobacteria,2MKSC@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilM_2,PilN
HFD3_k127_7451302_15	1408418.JNJH01000014_gene1875	9.38e-05	52.0	2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria	1224|Proteobacteria	S	General Secretion Pathway protein	xpsM	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM_b
HFD3_k127_7453858_12	1128421.JAGA01000003_gene2869	0.0004362	43.0	COG3880@1|root,COG3880@2|Bacteria,2NPCX@2323|unclassified Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrome_C7,GSu_C4xC__C2xCH,UVR
HFD3_k127_7453858_3	886293.Sinac_1866	1.116e-121	405.0	COG2204@1|root,COG2204@2|Bacteria,2IYHI@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD3_k127_7453858_9	502025.Hoch_5356	1.981e-08	60.0	29WSU@1|root,30IE6@2|Bacteria,1QDA3@1224|Proteobacteria,43276@68525|delta/epsilon subdivisions,2WXTW@28221|Deltaproteobacteria,2Z16N@29|Myxococcales	28221|Deltaproteobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD3_k127_7453858_6	754477.Q7C_2042	2.414e-14	75.0	COG5487@1|root,COG5487@2|Bacteria,1NCF3@1224|Proteobacteria,1SCWG@1236|Gammaproteobacteria,461H8@72273|Thiotrichales	72273|Thiotrichales	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HFD3_k127_7453858_11	443144.GM21_0541	9.226e-07	53.0	28T91@1|root,2ZFHN@2|Bacteria,1P659@1224|Proteobacteria,433I9@68525|delta/epsilon subdivisions,2WX6G@28221|Deltaproteobacteria,43VY2@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7453858_4	452637.Oter_2251	1.703e-54	206.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HFD3_k127_7453858_8	215803.DB30_2740	8.461e-13	70.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2YVDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD3_k127_7453858_2	247490.KSU1_B0488	1.081e-198	634.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,2IXQK@203682|Planctomycetes	203682|Planctomycetes	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
HFD3_k127_7453858_7	1234595.C725_1112	3.023e-14	75.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,4BR7Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase Ligase (LigD)	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD3_k127_7453858_5	1122135.KB893134_gene3766	5.251e-17	85.0	2EIAN@1|root,33C22@2|Bacteria,1NH5M@1224|Proteobacteria,2UJMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7453858_0	1254432.SCE1572_41890	4.721e-281	878.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,42NSN@68525|delta/epsilon subdivisions,2WJF7@28221|Deltaproteobacteria,2YX9T@29|Myxococcales	28221|Deltaproteobacteria	G	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HFD3_k127_7453858_1	234267.Acid_0218	3.019e-253	793.0	COG0296@1|root,COG0296@2|Bacteria,3Y33J@57723|Acidobacteria	57723|Acidobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HFD3_k127_7459857_9	237368.SCABRO_04027	5.007e-05	50.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	prnA	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
HFD3_k127_7459857_2	189753.AXAS01000041_gene2534	3.964e-77	265.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_7459857_8	1126627.BAWE01000002_gene637	5.63e-09	60.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_7459857_4	690850.Desaf_0799	1.218e-24	108.0	2C8BN@1|root,32RKS@2|Bacteria,1N7Z0@1224|Proteobacteria,42WEU@68525|delta/epsilon subdivisions,2WS8J@28221|Deltaproteobacteria,2MCC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7459857_6	596154.Alide2_2063	1.123e-09	62.0	COG3311@1|root,COG3311@2|Bacteria,1N72I@1224|Proteobacteria,2VSD4@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD3_k127_7459857_1	1071679.BG57_10360	3.535e-112	377.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3
HFD3_k127_7459857_0	1125863.JAFN01000001_gene1352	6.738e-114	384.0	COG0043@1|root,COG0043@2|Bacteria,1PZMY@1224|Proteobacteria,42RNW@68525|delta/epsilon subdivisions,2WNJN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HFD3_k127_7459857_5	207559.Dde_0991	6.401e-17	85.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HFD3_k127_7459857_3	1499684.CCNP01000023_gene3214	8.646e-30	123.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HFD3_k127_7475362_0	926559.JoomaDRAFT_2349	1.01e-65	242.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,4NKBD@976|Bacteroidetes,1I04I@117743|Flavobacteriia	976|Bacteroidetes	C	High-affinity Fe2 Pb2 permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
HFD3_k127_7475362_2	436308.Nmar_0873	8.112e-52	192.0	COG3639@1|root,arCOG00173@2157|Archaea,41SZI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	phosphonate ABC transporter, inner membrane subunit	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
HFD3_k127_7475362_3	1229909.NSED_04900	2.371e-42	168.0	COG3638@1|root,arCOG00206@2157|Archaea,41SY4@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC transporter	-	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
HFD3_k127_7475362_1	178306.PAE2700	2.958e-58	214.0	COG3221@1|root,arCOG01805@2157|Archaea	2157|Archaea	P	ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_7475362_4	357808.RoseRS_4549	2.823e-42	162.0	COG1321@1|root,COG1321@2|Bacteria,2G7DY@200795|Chloroflexi,3771X@32061|Chloroflexia	32061|Chloroflexia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HFD3_k127_7477540_4	330214.NIDE3895	0.0002699	44.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HFD3_k127_7477540_3	665571.STHERM_c05430	1.014e-34	154.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HFD3_k127_7477540_0	1173028.ANKO01000037_gene3769	3.692e-67	259.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HFD3_k127_7477540_2	484770.UFO1_3958	2.969e-41	176.0	COG4251@1|root,COG4251@2|Bacteria,1V0TU@1239|Firmicutes	1239|Firmicutes	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
HFD3_k127_7477540_1	1121007.AUML01000033_gene2786	4.719e-61	238.0	COG3202@1|root,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,1HWNK@117743|Flavobacteriia	976|Bacteroidetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
HFD3_k127_7497648_3	1232437.KL661978_gene3782	2.65e-54	198.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MJZH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HFD3_k127_7497648_4	1123261.AXDW01000007_gene2231	2.579e-49	184.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,1S5J1@1236|Gammaproteobacteria,1XCIQ@135614|Xanthomonadales	135614|Xanthomonadales	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD3_k127_7497648_0	1206720.BAFQ01000298_gene6814	7.64e-121	417.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_7497648_2	517418.Ctha_1581	1.968e-71	261.0	COG0612@1|root,COG0612@2|Bacteria,1FEWA@1090|Chlorobi	1090|Chlorobi	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_7497648_1	517418.Ctha_2620	3.095e-92	320.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_7497648_5	58344.JOEL01000003_gene1434	2.035e-36	147.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_7497648_7	1144310.PMI07_004507	3.073e-21	105.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,4B98I@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7497648_6	323097.Nham_1181	1.045e-30	131.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_7517012_3	1297742.A176_00743	4.913e-62	241.0	COG3210@1|root,COG4257@1|root,COG5276@1|root,COG3210@2|Bacteria,COG4257@2|Bacteria,COG5276@2|Bacteria,1R2UD@1224|Proteobacteria,43DGX@68525|delta/epsilon subdivisions,2X8NS@28221|Deltaproteobacteria,2Z130@29|Myxococcales	28221|Deltaproteobacteria	U	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HFD3_k127_7517012_5	661478.OP10G_1838	6.811e-48	192.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_7517012_9	386456.JQKN01000008_gene1452	7.87e-20	99.0	COG1853@1|root,arCOG02017@2157|Archaea,2XWBK@28890|Euryarchaeota	28890|Euryarchaeota	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HFD3_k127_7517012_6	1532558.JL39_00915	8.267e-45	177.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria,2UDSB@28211|Alphaproteobacteria,4BAAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_7517012_2	472759.Nhal_2724	1.921e-84	284.0	COG2324@1|root,COG2324@2|Bacteria	2|Bacteria	S	Carotenoid biosynthesis protein	cruF	-	5.5.1.19	ko:K22502	ko00906,map00906	-	R03824,R05341	RC01004	ko00000,ko00001,ko01000	-	-	-	Caroten_synth
HFD3_k127_7517012_7	743836.AYNA01000038_gene821	5.894e-44	164.0	2BW4Q@1|root,32QZ0@2|Bacteria,1N1UX@1224|Proteobacteria,2UNAT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HFD3_k127_7517012_1	56780.SYN_00437	6.3e-142	461.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MQ7W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD3_k127_7517012_0	404380.Gbem_0496	1.022e-175	559.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HFD3_k127_7517012_8	338963.Pcar_2198	6.616e-32	135.0	COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria,43SIM@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	POTRA domain, FtsQ-type	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HFD3_k127_7517012_4	867903.ThesuDRAFT_01659	1.057e-50	186.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3WCHN@538999|Clostridiales incertae sedis	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD3_k127_7517184_7	864069.MicloDRAFT_00043770	4.852e-29	119.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria,1JQWF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
HFD3_k127_7517184_3	886293.Sinac_4406	4.043e-79	278.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD3_k127_7517184_4	886293.Sinac_4404	1.242e-58	218.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HFD3_k127_7517184_2	335543.Sfum_3551	1.027e-116	389.0	COG0438@1|root,COG0438@2|Bacteria,1RAGT@1224|Proteobacteria,42Y8X@68525|delta/epsilon subdivisions,2WU97@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7517184_9	335283.Neut_2507	0.0007951	50.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,372PR@32003|Nitrosomonadales	28216|Betaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
HFD3_k127_7517184_1	335543.Sfum_1860	1.193e-237	748.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,43C63@68525|delta/epsilon subdivisions,2WTQK@28221|Deltaproteobacteria,2MSIN@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD3_k127_7517184_0	251229.Chro_2349	0.0	1091.0	COG1216@1|root,COG3934@1|root,COG1216@2|Bacteria,COG3934@2|Bacteria,1GQNZ@1117|Cyanobacteria	1117|Cyanobacteria	G	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_7517184_5	706587.Desti_4505	8.236e-57	205.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,42U27@68525|delta/epsilon subdivisions,2WR2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD3_k127_7517184_8	457429.ABJI02000571_gene696	4.698e-11	65.0	COG1141@1|root,COG1141@2|Bacteria,2IR4H@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
HFD3_k127_7517184_6	469383.Cwoe_4069	2.78e-45	175.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4CTCQ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_7519571_0	402777.KB235903_gene1841	6.456e-63	228.0	COG2199@1|root,COG3706@2|Bacteria,1G35Y@1117|Cyanobacteria,1H9VP@1150|Oscillatoriales	1117|Cyanobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,Response_reg
HFD3_k127_7519571_1	65093.PCC7418_2221	2.53e-45	181.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HFD3_k127_7519571_7	1202768.JROF01000011_gene711	3.448e-05	53.0	COG1917@1|root,arCOG02994@2157|Archaea,2XY1A@28890|Euryarchaeota,23WE5@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_7519571_2	1437603.BMON_0422	3.24e-19	99.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_7519571_6	1424334.W822_10480	9.483e-08	63.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria,3T1MD@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_7519571_3	1118054.CAGW01000075_gene3261	4.639e-16	91.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_7519571_5	266779.Meso_1060	3.749e-10	65.0	COG0346@1|root,COG0346@2|Bacteria,1Q8FC@1224|Proteobacteria,2V796@28211|Alphaproteobacteria,43Q1X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_4
HFD3_k127_7519571_4	693661.Arcve_1082	3.557e-10	70.0	COG0697@1|root,arCOG00272@2157|Archaea,2Y7E0@28890|Euryarchaeota,2471K@183980|Archaeoglobi	183980|Archaeoglobi	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD3_k127_7519571_8	1499967.BAYZ01000096_gene4317	5.458e-05	49.0	COG1402@1|root,COG1402@2|Bacteria,2NRPM@2323|unclassified Bacteria	2|Bacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HFD3_k127_754358_4	331869.BAL199_17958	2.449e-31	125.0	2DS7S@1|root,33EWX@2|Bacteria,1NDGE@1224|Proteobacteria,2UH4Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_754358_6	866895.HBHAL_4240	2.967e-13	76.0	COG3945@1|root,COG3945@2|Bacteria,1VD5M@1239|Firmicutes,4HM3K@91061|Bacilli,3NFPR@45667|Halobacillus	91061|Bacilli	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD3_k127_754358_1	1120983.KB894572_gene3272	2.463e-98	334.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,1JQ4A@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HFD3_k127_754358_2	395965.Msil_1885	3.969e-74	281.0	COG0642@1|root,COG2972@1|root,COG2205@2|Bacteria,COG2972@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,3N9SQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1
HFD3_k127_754358_5	189753.AXAS01000012_gene4337	1.147e-13	75.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_754358_7	1121422.AUMW01000010_gene1097	1.686e-08	64.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,260TI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_754358_8	565653.EGBG_01563	0.0003485	46.0	2EMDB@1|root,33F28@2|Bacteria,1VNI0@1239|Firmicutes,4I0KQ@91061|Bacilli,4B3ZA@81852|Enterococcaceae	91061|Bacilli	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD3_k127_754358_0	706587.Desti_4719	2.299e-138	447.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HFD3_k127_754358_3	706587.Desti_4720	1.284e-40	152.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HFD3_k127_7586142_0	1232410.KI421416_gene2600	3.506e-75	265.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,43U98@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HFD3_k127_7586142_2	1051632.TPY_3415	2.972e-45	177.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia	1239|Firmicutes	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HFD3_k127_7586142_3	443143.GM18_0270	6.53e-42	165.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WIVV@28221|Deltaproteobacteria,43UAF@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HFD3_k127_7586142_1	1449126.JQKL01000018_gene3295	5.583e-58	210.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,2691X@186813|unclassified Clostridiales	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD3_k127_7602021_4	1120934.KB894404_gene762	1.277e-06	56.0	COG0236@1|root,COG0236@2|Bacteria,2GT8W@201174|Actinobacteria	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD3_k127_7602021_3	1133849.O3I_034375	3.48e-51	201.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FTYX@85025|Nocardiaceae	201174|Actinobacteria	IQ	Acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HFD3_k127_7602021_1	1211115.ALIQ01000238_gene3256	9.965e-94	314.0	COG2242@1|root,COG2242@2|Bacteria,1R0I9@1224|Proteobacteria,2TZR6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HFD3_k127_7602021_2	1173028.ANKO01000224_gene1260	5.672e-78	276.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	1117|Cyanobacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_7602021_0	448385.sce4660	1.82e-124	411.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2X6ZP@28221|Deltaproteobacteria,2Z3JZ@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_7613416_2	1198452.Jab_2c08640	1.101e-24	108.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2VWJI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	STAS domain	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
HFD3_k127_7613416_3	338966.Ppro_1525	1.005e-23	107.0	COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,42V4M@68525|delta/epsilon subdivisions,2WRKJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	anti-sigma regulatory factor, serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HFD3_k127_7613416_1	1122604.JONR01000009_gene2309	5.147e-110	364.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HFD3_k127_7613416_0	1232683.ADIMK_3832	2.519e-128	436.0	COG2208@1|root,COG4252@1|root,COG2208@2|Bacteria,COG4252@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,46BPT@72275|Alteromonadaceae	1236|Gammaproteobacteria	KT	Sigma factor PP2C-like phosphatases	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
HFD3_k127_7615779_10	748247.AZKH_0922	7.068e-18	96.0	COG2199@1|root,COG5000@1|root,COG3706@2|Bacteria,COG5000@2|Bacteria,1MZV7@1224|Proteobacteria,2WI0C@28216|Betaproteobacteria,2KZVF@206389|Rhodocyclales	206389|Rhodocyclales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,PAS
HFD3_k127_7615779_7	706587.Desti_0365	1.144e-52	202.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,Fer2,GAF,GAF_2,Guanylate_cyc,Pkinase,Response_reg
HFD3_k127_7615779_4	485913.Krac_10225	6.935e-79	271.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD3_k127_7615779_6	485913.Krac_10224	1.392e-58	207.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_7615779_0	1380394.JADL01000004_gene5881	6.567e-162	518.0	COG2114@1|root,COG2114@2|Bacteria,1QTFI@1224|Proteobacteria,2TRNP@28211|Alphaproteobacteria,2JQC8@204441|Rhodospirillales	204441|Rhodospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HFD3_k127_7615779_2	1122604.JONR01000023_gene4156	7.708e-133	431.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X3BP@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD3_k127_7615779_1	1122604.JONR01000023_gene4155	1.991e-155	494.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1X36N@135614|Xanthomonadales	135614|Xanthomonadales	V	Multidrug ABC transporter ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_7615779_3	1254432.SCE1572_28970	1.06e-100	330.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,438B8@68525|delta/epsilon subdivisions,2X1TZ@28221|Deltaproteobacteria,2YWF2@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N
HFD3_k127_7615779_13	1157637.KB892126_gene3078	0.0001134	46.0	2BVHN@1|root,32QW3@2|Bacteria,2IKWS@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD3_k127_7615779_11	1068978.AMETH_0378	4.565e-14	78.0	2BVHN@1|root,32QW3@2|Bacteria,2IKWS@201174|Actinobacteria,4E3RM@85010|Pseudonocardiales	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD3_k127_7615779_5	861299.J421_0778	2.654e-68	238.0	COG0225@1|root,COG0225@2|Bacteria,1ZUAQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD3_k127_7615779_8	756272.Plabr_3437	3.941e-33	132.0	COG2010@1|root,COG2010@2|Bacteria,2J3TA@203682|Planctomycetes	203682|Planctomycetes	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HFD3_k127_7615779_9	1459636.NTE_01531	3.872e-26	118.0	COG0662@1|root,arCOG03003@2157|Archaea,41TAC@651137|Thaumarchaeota	651137|Thaumarchaeota	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_764939_3	42256.RradSPS_2495	5.934e-20	90.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD3_k127_764939_4	234267.Acid_4991	1.945e-16	82.0	2CBGA@1|root,32RQS@2|Bacteria,3Y586@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_764939_2	484770.UFO1_0327	3.086e-37	144.0	COG0346@1|root,COG0346@2|Bacteria,1V796@1239|Firmicutes	1239|Firmicutes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_764939_1	1121456.ATVA01000016_gene1920	4.292e-85	287.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2M9ZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HFD3_k127_764939_0	234267.Acid_0057	2.425e-127	425.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria	57723|Acidobacteria	Q	D-aminoacylase domain protein	-	-	3.5.1.81,3.5.2.3	ko:K01465,ko:K06015	ko00240,ko01100,map00240,map01100	M00051	R01993,R02192	RC00064,RC00328,RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
HFD3_k127_764939_5	32057.KB217478_gene7214	8.681e-14	78.0	2E828@1|root,3239F@2|Bacteria,1GHS1@1117|Cyanobacteria,1HTBH@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7682547_5	671143.DAMO_1168	2.962e-96	322.0	COG3264@1|root,COG3264@2|Bacteria	2|Bacteria	M	cellular water homeostasis	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	MS_channel,TM_helix
HFD3_k127_7682547_6	330214.NIDE1495	3.847e-36	139.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HFD3_k127_7682547_7	1499967.BAYZ01000034_gene1071	6.974e-21	96.0	2E46N@1|root,32Z2M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7682547_9	1121004.ATVC01000008_gene1094	0.0002209	47.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KPDK@206351|Neisseriales	206351|Neisseriales	L	Belongs to the methyltransferase superfamily	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HFD3_k127_7682547_1	864702.OsccyDRAFT_4267	5.93e-217	680.0	COG0448@1|root,COG0448@2|Bacteria,1G0IG@1117|Cyanobacteria,1H7C1@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.agp,iSbBS512_1146.agp	NTP_transferase
HFD3_k127_7682547_3	1288494.EBAPG3_13270	4e-154	496.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,372QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	THUMP	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HFD3_k127_7682547_4	56780.SYN_01220	1.999e-132	436.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2MR4K@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_7682547_8	378806.STAUR_6277	4.198e-17	87.0	COG1329@1|root,COG1329@2|Bacteria,1PD80@1224|Proteobacteria,438VF@68525|delta/epsilon subdivisions,2X5V4@28221|Deltaproteobacteria,2YXWM@29|Myxococcales	28221|Deltaproteobacteria	K	DNA binding domain with preference for A/T rich regions	-	-	-	-	-	-	-	-	-	-	-	-	CarD_CdnL_TRCF
HFD3_k127_7682547_2	1499967.BAYZ01000036_gene2419	7.439e-168	531.0	COG2152@1|root,COG2152@2|Bacteria,2NPB8@2323|unclassified Bacteria	2|Bacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
HFD3_k127_7682547_0	1499967.BAYZ01000036_gene2418	2.925e-284	879.0	COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD3_k127_7747487_6	1385518.N798_08450	2.856e-09	58.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4FF9B@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD3_k127_7747487_1	247490.KSU1_D0387	9.163e-192	606.0	COG0499@1|root,COG0499@2|Bacteria,2IXKQ@203682|Planctomycetes	203682|Planctomycetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HFD3_k127_7747487_10	1387312.BAUS01000007_gene2480	1.122e-06	58.0	2C02K@1|root,32R69@2|Bacteria,1RK2Q@1224|Proteobacteria,2W83M@28216|Betaproteobacteria,2KNRX@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7747487_0	1038860.AXAP01000146_gene3834	9.148e-202	643.0	COG0252@1|root,COG0252@2|Bacteria,1R4S1@1224|Proteobacteria	1224|Proteobacteria	EJ	Asparaginase	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase
HFD3_k127_7747487_2	397278.JOJN01000005_gene773	1.483e-81	284.0	2BZ0R@1|root,2Z7U0@2|Bacteria,2GU1J@201174|Actinobacteria,4DUY9@85009|Propionibacteriales	201174|Actinobacteria	S	Nitrile hydratase, alpha chain	nthA	-	4.2.1.84	ko:K01721	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha
HFD3_k127_7747487_8	1120973.AQXL01000134_gene1545	4.774e-08	55.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,2784T@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HFD3_k127_7747487_3	56780.SYN_01756	2.404e-26	122.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
HFD3_k127_7747487_4	56780.SYN_01757	8.691e-26	114.0	COG4966@1|root,COG4966@2|Bacteria,1Q8WE@1224|Proteobacteria,439J3@68525|delta/epsilon subdivisions,2X4VK@28221|Deltaproteobacteria,2MSHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HFD3_k127_7747487_7	56780.SYN_01760	1.932e-08	61.0	COG4967@1|root,COG4967@2|Bacteria,1NI49@1224|Proteobacteria	1224|Proteobacteria	NU	type IV pilus modification protein PilV	pilV	-	-	ko:K02458,ko:K02671	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	N_methyl
HFD3_k127_7747487_9	1333856.L686_13085	2.005e-07	59.0	COG4970@1|root,COG4970@2|Bacteria,1N43I@1224|Proteobacteria,1SX5W@1236|Gammaproteobacteria,1Z3ED@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	NU	COG4970 Tfp pilus assembly protein FimT	-	-	-	ko:K08085	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
HFD3_k127_7752250_4	189753.AXAS01000056_gene5959	6.908e-14	72.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_7752250_6	497964.CfE428DRAFT_6311	1.601e-08	61.0	299BV@1|root,2ZWES@2|Bacteria,46WNG@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_7752250_5	4006.Lus10036886	3.941e-11	67.0	COG1004@1|root,KOG2666@2759|Eukaryota,37K9E@33090|Viridiplantae,3G8DJ@35493|Streptophyta,4JSZH@91835|fabids	35493|Streptophyta	GT	UDP-glucose 6-dehydrogenase	-	GO:0003674,GO:0003824,GO:0003979,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006065,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030203,GO:0034641,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046398,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_7752250_2	867845.KI911784_gene3219	1.479e-71	244.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_7752250_1	309801.trd_1208	2.881e-74	259.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi,27XP9@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_7752250_3	189753.AXAS01000041_gene2534	2.181e-66	238.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HFD3_k127_7752250_0	644966.Tmar_0545	1.115e-221	711.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_780875_7	243233.MCA2966	5.29e-59	213.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD3_k127_780875_9	1401065.HMPREF2130_03535	2.442e-52	200.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,3T2UQ@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD3_k127_780875_12	324602.Caur_3644	4.074e-44	169.0	COG0500@1|root,COG2226@2|Bacteria,2G6T6@200795|Chloroflexi,375HK@32061|Chloroflexia	32061|Chloroflexia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD3_k127_780875_16	314230.DSM3645_01776	3.301e-14	83.0	2EEQZ@1|root,338IP@2|Bacteria,2J15B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_780875_3	713587.THITH_10380	3.542e-72	251.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD3_k127_780875_0	1122603.ATVI01000009_gene2646	1.519e-272	845.0	COG1075@1|root,COG1075@2|Bacteria,1MXMP@1224|Proteobacteria,1RYZM@1236|Gammaproteobacteria,1X44F@135614|Xanthomonadales	135614|Xanthomonadales	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
HFD3_k127_780875_5	661478.OP10G_0347	9.738e-70	239.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD3_k127_780875_18	709797.CSIRO_2825	5.502e-11	68.0	COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2TV8V@28211|Alphaproteobacteria,3JTX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD3_k127_780875_4	386456.JQKN01000012_gene1063	2.215e-70	241.0	COG1513@1|root,arCOG01488@2157|Archaea,2XXZW@28890|Euryarchaeota	28890|Euryarchaeota	F	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HFD3_k127_780875_10	1229780.BN381_130292	2.717e-51	188.0	293RJ@1|root,2ZR76@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD3_k127_780875_13	1165841.SULAR_03802	6.251e-32	130.0	COG4564@1|root,COG4564@2|Bacteria,1N7NM@1224|Proteobacteria,42W17@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	PFAM Cache	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	dCache_2,sCache_2
HFD3_k127_780875_20	929556.Solca_1355	4.314e-05	50.0	COG0662@1|root,COG0662@2|Bacteria,4NQIP@976|Bacteroidetes,1IZZH@117747|Sphingobacteriia	976|Bacteroidetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_780875_2	479434.Sthe_1231	2.966e-100	334.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD3_k127_780875_8	323261.Noc_1568	5.518e-55	194.0	COG2337@1|root,COG2337@2|Bacteria,1RIPH@1224|Proteobacteria,1S7VW@1236|Gammaproteobacteria,1WYQY@135613|Chromatiales	135613|Chromatiales	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HFD3_k127_780875_11	671143.DAMO_1860	1.173e-47	174.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HFD3_k127_780875_14	706587.Desti_0629	4.766e-20	93.0	COG5450@1|root,COG5450@2|Bacteria,1Q2TR@1224|Proteobacteria,42W8I@68525|delta/epsilon subdivisions,2WRTI@28221|Deltaproteobacteria,2MS5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HFD3_k127_780875_1	713586.KB900536_gene1287	8.151e-170	548.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_780875_6	1055815.AYYA01000069_gene1740	3.703e-65	238.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,1RMG8@1236|Gammaproteobacteria,3NJN3@468|Moraxellaceae	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HFD3_k127_780875_15	404589.Anae109_3668	8.315e-17	80.0	COG2197@1|root,COG2197@2|Bacteria,1R03J@1224|Proteobacteria	1224|Proteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HFD3_k127_782564_0	1242864.D187_008792	4.987e-92	321.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD3_k127_782564_1	309801.trd_0447	2.082e-89	307.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi,27XXF@189775|Thermomicrobia	189775|Thermomicrobia	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HFD3_k127_782564_2	443152.MDG893_15085	1.777e-52	198.0	COG3181@1|root,COG3181@2|Bacteria,1RJGP@1224|Proteobacteria,1SZ9G@1236|Gammaproteobacteria,46CCT@72275|Alteromonadaceae	1224|Proteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_782564_3	1123023.JIAI01000001_gene6772	5.626e-08	54.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4DZ54@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD3_k127_790743_5	926690.KE386573_gene796	8.251e-47	179.0	COG0600@1|root,arCOG00169@2157|Archaea,2XXW6@28890|Euryarchaeota,23WH6@183963|Halobacteria	183963|Halobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HFD3_k127_790743_2	1227499.C493_00160	3.183e-59	213.0	COG1116@1|root,arCOG00193@2157|Archaea,2XXDP@28890|Euryarchaeota,23VWW@183963|Halobacteria	183963|Halobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HFD3_k127_790743_9	1131814.JAFO01000001_gene1772	1.727e-08	66.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,3EXYH@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_790743_10	4952.CAG81927	0.000955	49.0	COG0457@1|root,KOG0548@2759|Eukaryota,38GCK@33154|Opisthokonta,3NUK2@4751|Fungi,3QM6I@4890|Ascomycota,3RT2J@4891|Saccharomycetes	4751|Fungi	O	to Saccharomyces cerevisiae STI1 (YOR027W)	STI1	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0008104,GO:0008150,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0030234,GO:0030544,GO:0031072,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042030,GO:0042886,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0045184,GO:0046907,GO:0050790,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051879,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072655,GO:0097159,GO:0098772,GO:1901363	-	ko:K09553	ko05020,map05020	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_8
HFD3_k127_790743_0	1192034.CAP_3408	3.72e-195	627.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD3_k127_790743_1	667014.Thein_0035	4.006e-106	367.0	COG0358@1|root,COG0358@2|Bacteria,2GHQG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
HFD3_k127_790743_8	880072.Desac_2618	7.458e-15	81.0	COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MSCN@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HFD3_k127_790743_6	1499967.BAYZ01000073_gene2011	2.087e-32	132.0	COG1610@1|root,COG1610@2|Bacteria,2NPQ9@2323|unclassified Bacteria	2|Bacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HFD3_k127_790743_7	404589.Anae109_0759	2.248e-21	94.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD3_k127_790743_4	1540257.JQMW01000013_gene1210	2.368e-47	179.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,36F9I@31979|Clostridiaceae	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HFD3_k127_790743_3	269799.Gmet_1222	5.582e-55	196.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,43S7C@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD3_k127_791517_1	1381123.AYOD01000013_gene2195	2.596e-126	421.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,43I4Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HFD3_k127_791517_6	1293048.CBMB010000004_gene2592	1.447e-56	213.0	COG0006@1|root,arCOG01000@2157|Archaea,2XVY0@28890|Euryarchaeota,23U8B@183963|Halobacteria	183963|Halobacteria	E	COG0006 Xaa-Pro aminopeptidase	pepB5	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_791517_12	266779.Meso_0806	1.15e-12	79.0	COG0715@1|root,COG0715@2|Bacteria,1NAXC@1224|Proteobacteria,2U2C2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_791517_11	234267.Acid_2763	5.844e-13	81.0	COG3291@1|root,COG4625@1|root,COG3291@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	2|Bacteria	M	PKD domain containing protein	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_3_5,DUF1080,He_PIG,PATR
HFD3_k127_791517_2	1134912.AJTV01000030_gene2088	4.004e-103	353.0	COG2755@1|root,COG3291@1|root,COG2755@2|Bacteria,COG3291@2|Bacteria,1MYCW@1224|Proteobacteria	1224|Proteobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PA
HFD3_k127_791517_8	1449126.JQKL01000019_gene3240	9.933e-36	151.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,269AS@186813|unclassified Clostridiales	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HFD3_k127_791517_9	1295642.H839_02276	1.448e-31	139.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,1WFAK@129337|Geobacillus	91061|Bacilli	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_791517_5	1040989.AWZU01000026_gene2877	6.76e-58	205.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2TTXF@28211|Alphaproteobacteria,3JRB1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HFD3_k127_791517_3	397945.Aave_3268	1.002e-68	242.0	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2VJ7W@28216|Betaproteobacteria,4ADUX@80864|Comamonadaceae	28216|Betaproteobacteria	P	extracellular solute-binding protein, family 1	-	-	5.3.3.7	ko:K22003	ko00660,map00660	-	R02244	RC00668	ko00000,ko00001,ko01000	-	-	-	SBP_bac_11
HFD3_k127_791517_7	909663.KI867150_gene2871	8.38e-38	145.0	COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
HFD3_k127_791517_0	497964.CfE428DRAFT_2531	9.332e-165	533.0	COG1216@1|root,COG4976@1|root,COG1216@2|Bacteria,COG4976@2|Bacteria,46W0C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD3_k127_791517_4	344747.PM8797T_14474	1.249e-64	227.0	COG1053@1|root,COG1053@2|Bacteria,2J3SP@203682|Planctomycetes	203682|Planctomycetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HFD3_k127_799753_13	316067.Geob_0474	3.331e-20	93.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD3_k127_799753_1	237368.SCABRO_01997	8.968e-136	447.0	COG1007@1|root,COG1007@2|Bacteria,2IXC6@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD3_k127_799753_15	1346330.M472_20285	1.578e-05	56.0	COG4632@1|root,COG4632@2|Bacteria,4NQZB@976|Bacteroidetes,1IRTS@117747|Sphingobacteriia	976|Bacteroidetes	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HFD3_k127_799753_16	419947.MRA_3586	7.976e-05	50.0	COG0748@1|root,COG0748@2|Bacteria,2IIRE@201174|Actinobacteria,239MD@1762|Mycobacteriaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	ddn	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HFD3_k127_799753_4	1231391.AMZF01000019_gene2027	6.225e-66	235.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HFD3_k127_799753_12	258594.RPA3589	5.507e-21	97.0	2EHVD@1|root,33BKY@2|Bacteria,1NAJU@1224|Proteobacteria,2UHP0@28211|Alphaproteobacteria,3K1GK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_799753_10	670292.JH26_22525	2.531e-41	157.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2U67J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD3_k127_799753_5	484770.UFO1_0918	8.497e-65	229.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,4H4ZT@909932|Negativicutes	909932|Negativicutes	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HFD3_k127_799753_6	1231391.AMZF01000068_gene2180	9.774e-60	219.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_799753_11	1500894.JQNN01000001_gene3203	2.402e-28	119.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,4748U@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HFD3_k127_799753_7	316058.RPB_4414	1.971e-53	199.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TTJF@28211|Alphaproteobacteria,3K3D3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HFD3_k127_799753_0	319003.Bra1253DRAFT_02622	7.151e-172	566.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_799753_8	370438.PTH_1579	3.701e-51	186.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,26208@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD3_k127_799753_9	469383.Cwoe_4069	3.473e-48	185.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4CTCQ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_799753_3	1298860.AUEM01000001_gene1427	1.462e-88	301.0	COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria,4FQUP@85023|Microbacteriaceae	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HFD3_k127_799753_2	469383.Cwoe_4099	1.124e-92	314.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_808672_1	338966.Ppro_2304	8.163e-134	434.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,43TP6@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
HFD3_k127_808672_0	335543.Sfum_0429	1.428e-152	506.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MQAI@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HFD3_k127_808672_4	316067.Geob_3359	2.057e-32	128.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42TK0@68525|delta/epsilon subdivisions,2WQ5D@28221|Deltaproteobacteria,43V44@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD3_k127_808672_6	706587.Desti_3849	1.096e-28	118.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,2MSHG@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD3_k127_808672_3	1121403.AUCV01000005_gene245	2.948e-53	191.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2WP3N@28221|Deltaproteobacteria,2MNMX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HFD3_k127_808672_5	237368.SCABRO_00875	5.473e-29	120.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HFD3_k127_808672_7	32057.KB217478_gene3414	1.36e-05	50.0	2DPW4@1|root,333N7@2|Bacteria,1GGTQ@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM YgiT-type zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_808672_2	645991.Sgly_3094	2.24e-73	266.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,2610Z@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD3_k127_809535_4	1144319.PMI16_01052	5.549e-07	61.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,476K9@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PAS fold	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_9,Response_reg
HFD3_k127_809535_5	983917.RGE_04130	3.172e-06	49.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,1KJTK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD3_k127_809535_3	880072.Desac_2196	1.742e-09	62.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2MQS7@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD3_k127_809535_0	1128421.JAGA01000003_gene3206	2.93e-59	211.0	COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD3_k127_809535_1	290397.Adeh_4279	3.505e-31	126.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2YVAN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HFD3_k127_809535_6	1198232.CYCME_1450	0.0004353	44.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,1RXH8@1236|Gammaproteobacteria,4633T@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HFD3_k127_809535_2	118163.Ple7327_1767	2.093e-23	102.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria,3VNJZ@52604|Pleurocapsales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HFD3_k127_813289_8	257313.BP3674	3.75e-06	57.0	COG4521@1|root,COG4521@2|Bacteria,1QVY3@1224|Proteobacteria,2VN3S@28216|Betaproteobacteria,3T2RS@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC transporter substrate-binding protein	-	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
HFD3_k127_813289_6	502025.Hoch_0180	1.846e-32	135.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HFD3_k127_813289_5	671143.DAMO_2378	2.158e-35	138.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HFD3_k127_813289_4	497964.CfE428DRAFT_0259	6.52e-52	189.0	COG2151@1|root,COG2151@2|Bacteria,46SWX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HFD3_k127_813289_3	1198232.CYCME_1545	1.044e-54	196.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,461GC@72273|Thiotrichales	72273|Thiotrichales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HFD3_k127_813289_0	472759.Nhal_0691	1.607e-180	573.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
HFD3_k127_813289_2	671143.DAMO_2381	9.994e-125	413.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
HFD3_k127_813289_1	671143.DAMO_2382	4.174e-125	404.0	COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria	2|Bacteria	O	ABC transporter	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	ABC_tran
HFD3_k127_813289_7	1191523.MROS_1959	3.607e-16	85.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD3_k127_817359_2	1356854.N007_16795	7.019e-47	173.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli	91061|Bacilli	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HFD3_k127_817359_0	648757.Rvan_3586	2.893e-88	297.0	COG4887@1|root,COG4887@2|Bacteria,1RKM1@1224|Proteobacteria,2U481@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1847)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
HFD3_k127_817359_1	525897.Dbac_1842	6.611e-47	182.0	COG1840@1|root,COG1840@2|Bacteria,1N9WT@1224|Proteobacteria	1224|Proteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_817359_3	631362.Thi970DRAFT_04965	1.977e-05	55.0	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1WZEE@135613|Chromatiales	135613|Chromatiales	S	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
HFD3_k127_817359_4	909663.KI867150_gene2871	0.0004793	45.0	COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
HFD3_k127_817786_4	1122915.AUGY01000118_gene6536	1.363e-27	124.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_817786_6	1380763.BG53_13185	5.806e-21	104.0	COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,4HCK6@91061|Bacilli,26Z66@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1,NMT1_2
HFD3_k127_817786_3	1449063.JMLS01000007_gene3546	7.213e-32	134.0	COG3619@1|root,COG3619@2|Bacteria,1VBZN@1239|Firmicutes,4HMQK@91061|Bacilli,26YPB@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1275)	yoaK	-	-	-	-	-	-	-	-	-	-	-	DUF1275
HFD3_k127_817786_0	1380394.JADL01000012_gene856	2.734e-175	571.0	28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_817786_2	1122214.AQWH01000003_gene3922	1.307e-79	279.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HFD3_k127_817786_1	1231391.AMZF01000063_gene1102	8.152e-112	378.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HFD3_k127_824002_1	748247.AZKH_p0136	9.653e-88	310.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VQCJ@28216|Betaproteobacteria,2KY98@206389|Rhodocyclales	206389|Rhodocyclales	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	ko:K16874	ko00365,ko01120,map00365,map01120	-	R10213	RC03086	ko00000,ko00001	-	-	-	UbiD
HFD3_k127_824002_0	717785.HYPMC_0264	1.52e-119	400.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_824002_2	172088.AUGA01000009_gene1612	9.184e-61	222.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,3JQT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_825221_11	693444.D782_4220	8.919e-25	104.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,1SDHP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
HFD3_k127_825221_12	1205680.CAKO01000002_gene2477	3.274e-20	90.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,2JUN0@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD3_k127_825221_5	1232410.KI421413_gene478	1.323e-96	329.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42UYG@68525|delta/epsilon subdivisions,2WR4P@28221|Deltaproteobacteria,43V2Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD3_k127_825221_1	1123368.AUIS01000032_gene1398	4.488e-223	713.0	COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2,SNARE_assoc
HFD3_k127_825221_7	1123368.AUIS01000032_gene1399	9.69e-61	224.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD3_k127_825221_6	1335760.ASTG01000003_gene1552	6.131e-75	267.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,ParD_antitoxin,Response_reg
HFD3_k127_825221_15	1458357.BG58_22545	1.172e-10	68.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1K48U@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg,dCache_1
HFD3_k127_825221_9	1121022.ABENE_14360	4.725e-32	133.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2U7JS@28211|Alphaproteobacteria,2KH99@204458|Caulobacterales	204458|Caulobacterales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD3_k127_825221_18	1435356.Y013_20385	0.0004026	45.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FU1R@85025|Nocardiaceae	201174|Actinobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HFD3_k127_825221_17	93220.LV28_14400	1.581e-05	48.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2VMW2@28216|Betaproteobacteria,1K3HB@119060|Burkholderiaceae	28216|Betaproteobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
HFD3_k127_825221_8	977880.RALTA_A1620	8.186e-39	150.0	COG4244@1|root,COG4244@2|Bacteria,1NJGN@1224|Proteobacteria,2VYSI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD3_k127_825221_2	63737.Npun_R3642	2.52e-137	445.0	COG0673@1|root,COG0673@2|Bacteria,1G18V@1117|Cyanobacteria,1HN0A@1161|Nostocales	1117|Cyanobacteria	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	1.1.1.335,1.1.99.28	ko:K00118,ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HFD3_k127_825221_3	1211114.ALIP01000156_gene3003	5.906e-124	422.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,1X4Z4@135614|Xanthomonadales	135614|Xanthomonadales	M	protein involved in outer membrane biogenesis	asmA	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA
HFD3_k127_825221_0	1173023.KE650771_gene2604	1.676e-296	917.0	COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,1JJ9X@1189|Stigonemataceae	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_825221_13	859657.RPSI07_0590	1.815e-19	98.0	COG2943@1|root,COG3416@1|root,COG2943@2|Bacteria,COG3416@2|Bacteria,1MVXZ@1224|Proteobacteria,2VHDC@28216|Betaproteobacteria,1K3T0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	opgH	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3,Glycos_transf_2
HFD3_k127_825221_4	1267534.KB906756_gene683	3.859e-118	388.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	ko:K03420,ko:K13525,ko:K17681	ko03050,ko04141,ko05134,map03050,map04141,map05134	M00343,M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko03029,ko03051,ko04131,ko04147	3.A.16.1	-	-	AAA
HFD3_k127_825221_10	404589.Anae109_1302	1.156e-29	124.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2YXCT@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase beta thumb	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HFD3_k127_825221_16	215803.DB30_5586	3.551e-09	61.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1RCVN@1224|Proteobacteria	1224|Proteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HFD3_k127_827059_5	1499967.BAYZ01000147_gene728	1.782e-54	213.0	COG0741@1|root,COG4105@1|root,COG0741@2|Bacteria,COG4105@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K06381,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6,TPR_8
HFD3_k127_827059_7	662479.C440_13704	1.779e-19	94.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX4R@28890|Euryarchaeota,23WPM@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_827059_3	1163617.SCD_n00201	1.132e-119	390.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD3_k127_827059_6	671143.DAMO_2493	1.721e-32	129.0	COG2329@1|root,COG2329@2|Bacteria,2NS2V@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	isdG	-	1.14.99.48,1.14.99.57	ko:K07145,ko:K21481	ko00860,ko01110,map00860,map01110	-	R10468,R10510	RC03185	ko00000,ko00001,ko01000	-	-	-	ABM
HFD3_k127_827059_10	768679.TTX_0014	2.287e-06	57.0	COG0251@1|root,arCOG01630@2157|Archaea,2XQQW@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD3_k127_827059_8	1122915.AUGY01000118_gene6536	3.896e-19	99.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,26UBJ@186822|Paenibacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_827059_2	195105.CN97_19055	1.373e-148	486.0	COG0747@1|root,COG0747@2|Bacteria,1MWGY@1224|Proteobacteria,2TR73@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_827059_9	935840.JAEQ01000004_gene646	3.552e-15	87.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_827059_4	1380355.JNIJ01000031_gene3513	2.365e-100	338.0	COG2141@1|root,COG2141@2|Bacteria,1QGWA@1224|Proteobacteria,2UNBA@28211|Alphaproteobacteria,3K5C8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HFD3_k127_827059_0	479434.Sthe_2889	5.947e-250	788.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	2|Bacteria	EQ	Hydantoinaseoxoprolinase domain protein	oplaH	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HFD3_k127_827059_1	1125971.ASJB01000043_gene3379	8.303e-161	516.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4E8PZ@85010|Pseudonocardiales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_831982_1	1144343.PMI41_00111	7.271e-12	76.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2U6AN@28211|Alphaproteobacteria,43PC3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2
HFD3_k127_831982_0	257310.BB2455	6.68e-13	79.0	COG0715@1|root,COG0715@2|Bacteria,1MVUJ@1224|Proteobacteria,2W9A2@28216|Betaproteobacteria,3T6BS@506|Alcaligenaceae	28216|Betaproteobacteria	P	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_831982_2	574376.BAMA_12925	1.018e-05	55.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,4HAB9@91061|Bacilli,1ZC0Z@1386|Bacillus	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	ytlA	GO:0003674,GO:0005215	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_840343_4	1301098.PKB_3422	1.765e-38	155.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,1RPKM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	deacetylase	puuE	-	3.5.1.104,3.5.1.41,3.5.2.5	ko:K01452,ko:K16842,ko:K22278	ko00230,ko00520,ko01100,ko01120,map00230,map00520,map01100,map01120	M00546	R02333,R02425	RC00166,RC00300,RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Polysacc_deac_1
HFD3_k127_840343_0	479434.Sthe_1925	3.471e-97	340.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,27YWM@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD3_k127_840343_3	1200792.AKYF01000019_gene4644	4.213e-66	245.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_840343_2	656519.Halsa_1628	1.526e-73	268.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HFD3_k127_840343_1	195105.CN97_19065	8.104e-85	291.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HFD3_k127_840343_5	1089553.Tph_c03530	2.587e-36	140.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FXH@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HFD3_k127_84213_7	330214.NIDE0503	8.008e-56	198.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD3_k127_84213_11	1131269.AQVV01000045_gene1583	1.13e-36	144.0	COG0801@1|root,COG0801@2|Bacteria	2|Bacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0041	FolB,HPPK
HFD3_k127_84213_18	1121918.ARWE01000001_gene235	4.79e-06	55.0	COG3350@1|root,COG3350@2|Bacteria	2|Bacteria	T	monooxygenase activity	tmoA	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1	ko:K00688,ko:K15760,ko:K16157,ko:K16242,ko:K18223,ko:K22353,ko:K22357	ko00361,ko00362,ko00500,ko00623,ko00625,ko00640,ko00680,ko01100,ko01110,ko01120,ko01200,ko01220,ko02026,ko04217,ko04910,ko04922,ko04931,map00361,map00362,map00500,map00623,map00625,map00640,map00680,map01100,map01110,map01120,map01200,map01220,map02026,map04217,map04910,map04922,map04931	M00174,M00538,M00548	R01142,R02111,R02550,R03560,R03562,R03608,R05444,R05666,R10042,R10043,R10702,R11901	RC00046,RC00173,RC00269,RC00490,RC01383,RC03249	ko00000,ko00001,ko00002,ko01000	-	GT35	-	Phenol_Hydrox,YHS
HFD3_k127_84213_2	566466.NOR53_1440	3.329e-162	516.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1J4IE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Gp_dh_C,Gp_dh_N
HFD3_k127_84213_3	247634.GPB2148_1532	8.639e-117	385.0	COG0057@1|root,COG0057@2|Bacteria,1NT8P@1224|Proteobacteria,1SJQU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Gp_dh_C,Gp_dh_N
HFD3_k127_84213_14	1118054.CAGW01000075_gene3261	6.173e-24	113.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_84213_0	706587.Desti_3265	6.554e-196	622.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HFD3_k127_84213_6	1117943.SFHH103_02831	1.809e-57	213.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,4BACM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_84213_13	861299.J421_0534	3.547e-28	120.0	COG4032@1|root,COG4032@2|Bacteria	2|Bacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD3_k127_84213_12	1177594.MIC448_1190029	7.909e-36	149.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.1.79	ko:K13039	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD3_k127_84213_9	1500259.JQLD01000014_gene1680	1.958e-45	178.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HFD3_k127_84213_15	935840.JAEQ01000004_gene646	1.399e-21	108.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,43JZT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_84213_10	118168.MC7420_6291	2.52e-45	176.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,1HAC9@1150|Oscillatoriales	1117|Cyanobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_84213_19	13735.ENSPSIP00000002410	0.0002265	54.0	28KWP@1|root,2QTDA@2759|Eukaryota,38G3J@33154|Opisthokonta,3BFXR@33208|Metazoa,3CZQH@33213|Bilateria,47Z9Z@7711|Chordata,495JI@7742|Vertebrata,4C927@8459|Testudines	33208|Metazoa	S	Nuclear mitotic apparatus protein 1	NUMA1	GO:0000132,GO:0000226,GO:0000235,GO:0000278,GO:0000922,GO:0001578,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005815,GO:0005818,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005876,GO:0005881,GO:0005886,GO:0005938,GO:0006355,GO:0006357,GO:0006996,GO:0006997,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007088,GO:0007163,GO:0007346,GO:0008017,GO:0008022,GO:0008092,GO:0008150,GO:0008289,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010638,GO:0010646,GO:0010647,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016363,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0019904,GO:0022402,GO:0022607,GO:0023051,GO:0023056,GO:0030010,GO:0030425,GO:0030510,GO:0030513,GO:0030856,GO:0030858,GO:0030863,GO:0030953,GO:0030981,GO:0031110,GO:0031112,GO:0031113,GO:0031116,GO:0031122,GO:0031323,GO:0031326,GO:0031334,GO:0031616,GO:0031974,GO:0031981,GO:0032271,GO:0032273,GO:0032386,GO:0032388,GO:0032879,GO:0032880,GO:0032886,GO:0032887,GO:0032888,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034399,GO:0035091,GO:0035371,GO:0036449,GO:0036477,GO:0040001,GO:0042634,GO:0042635,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0044085,GO:0044087,GO:0044089,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045595,GO:0045597,GO:0045604,GO:0045606,GO:0045616,GO:0045618,GO:0045682,GO:0045684,GO:0045787,GO:0045840,GO:0045931,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050793,GO:0050794,GO:0051010,GO:0051011,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051225,GO:0051233,GO:0051234,GO:0051239,GO:0051240,GO:0051252,GO:0051293,GO:0051294,GO:0051493,GO:0051495,GO:0051640,GO:0051641,GO:0051649,GO:0051653,GO:0051656,GO:0051726,GO:0051783,GO:0051785,GO:0051797,GO:0051798,GO:0051983,GO:0051984,GO:0055028,GO:0055048,GO:0060236,GO:0060255,GO:0060341,GO:0061673,GO:0062033,GO:0065007,GO:0070013,GO:0070507,GO:0070840,GO:0070925,GO:0071840,GO:0071944,GO:0072686,GO:0080090,GO:0090068,GO:0090092,GO:0090100,GO:0090169,GO:0090224,GO:0090235,GO:0090287,GO:0097427,GO:0097431,GO:0097435,GO:0097447,GO:0097458,GO:0097574,GO:0097575,GO:0097718,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099568,GO:0099738,GO:0110028,GO:0120025,GO:0120038,GO:1902115,GO:1902117,GO:1902363,GO:1902365,GO:1902846,GO:1902850,GO:1902903,GO:1902905,GO:1903047,GO:1903506,GO:1903827,GO:1903829,GO:1904375,GO:1904377,GO:1904776,GO:1904778,GO:1905720,GO:1905818,GO:1905820,GO:1905832,GO:1990023,GO:1990752,GO:2000026,GO:2000112,GO:2001141,GO:2001252	-	ko:K16808	-	-	-	-	ko00000,ko03036	-	-	-	-
HFD3_k127_84213_4	1095769.CAHF01000017_gene30	2.84e-102	342.0	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2VIYW@28216|Betaproteobacteria,473R6@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	gstP	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
HFD3_k127_84213_16	1184267.A11Q_422	2.32e-19	91.0	2BW7N@1|root,32Z97@2|Bacteria,1P2ZF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_84213_1	1205680.CAKO01000002_gene2931	1.413e-164	537.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TT2P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	elongator protein 3 miab nifb	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD3_k127_84213_5	1192034.CAP_6251	1.468e-94	322.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	1224|Proteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HFD3_k127_84213_8	1343740.M271_50225	8.839e-53	193.0	COG1063@1|root,COG1063@2|Bacteria,2GMNX@201174|Actinobacteria	201174|Actinobacteria	E	dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HFD3_k127_84547_7	1123368.AUIS01000004_gene260	2.016e-44	166.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,2NCW6@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HFD3_k127_84547_3	562970.Btus_1483	2.743e-134	434.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,2792C@186823|Alicyclobacillaceae	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HFD3_k127_84547_1	796606.BMMGA3_06055	7.348e-160	512.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli,1ZB9P@1386|Bacillus	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU16090	ATP-grasp_2,Ligase_CoA
HFD3_k127_84547_5	653733.Selin_2133	1.154e-113	375.0	COG0039@1|root,COG0039@2|Bacteria	2|Bacteria	C	L-malate dehydrogenase activity	mdh	GO:0003674,GO:0003824,GO:0004470,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1360	Ldh_1_C,Ldh_1_N
HFD3_k127_84547_0	1192034.CAP_3742	9.992e-208	655.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2YYDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD3_k127_84547_8	502025.Hoch_3876	7.475e-44	177.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria,2YXDF@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
HFD3_k127_84547_6	1331060.RLDS_22000	1.95e-75	260.0	COG1024@1|root,COG1024@2|Bacteria,1MY8F@1224|Proteobacteria,2U9B9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD3_k127_84547_4	706587.Desti_0681	1.266e-130	444.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales	2|Bacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD3_k127_84547_12	1380394.JADL01000013_gene609	1.834e-10	72.0	COG0715@1|root,COG0715@2|Bacteria,1QSRN@1224|Proteobacteria,2VFVR@28211|Alphaproteobacteria	1224|Proteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_84547_2	1123501.KB902290_gene1567	6.609e-153	499.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182,ko:K16874	ko00130,ko00365,ko01100,ko01110,ko01120,map00130,map00365,map01100,map01110,map01120	M00117	R04985,R04986,R10213	RC00391,RC03086	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_84547_11	1041139.KB902646_gene3338	2.396e-11	75.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,2U4A5@28211|Alphaproteobacteria,4BBDJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_84547_10	1170562.Cal6303_1184	1.216e-11	71.0	2E712@1|root,331JU@2|Bacteria,1G93M@1117|Cyanobacteria,1HSZ0@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_84547_9	448385.sce6459	3.818e-40	169.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_868253_38	640081.Dsui_2122	1.114e-16	90.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2WEG1@28216|Betaproteobacteria,2KVYA@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_868253_14	656024.FsymDg_0185	1.887e-74	255.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4ESIC@85013|Frankiales	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD3_k127_868253_44	37919.EP51_23825	4.296e-12	77.0	COG0715@1|root,COG0715@2|Bacteria,2HHNY@201174|Actinobacteria,4FZGF@85025|Nocardiaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_868253_23	240292.Ava_3256	4.311e-30	130.0	2E6E7@1|root,3311P@2|Bacteria,1GDDS@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_868253_29	1173028.ANKO01000158_gene4530	6.286e-25	111.0	2EWB0@1|root,33PPQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_868253_28	330214.NIDE3689	5.355e-26	109.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HFD3_k127_868253_21	330214.NIDE3688	2.466e-31	125.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	relF	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048	-	-	-	PhdYeFM_antitox
HFD3_k127_868253_10	926569.ANT_14850	3.103e-93	317.0	COG2055@1|root,COG2055@2|Bacteria,2G6M2@200795|Chloroflexi	200795|Chloroflexi	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HFD3_k127_868253_40	1122915.AUGY01000020_gene6479	1.469e-15	88.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_868253_47	1347369.CCAD010000028_gene1344	7.611e-06	51.0	COG4756@1|root,COG4756@2|Bacteria,1TR8T@1239|Firmicutes,4HET9@91061|Bacilli,1ZDGH@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF1646)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1646
HFD3_k127_868253_20	448385.sce0123	9.41e-34	136.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2Z0V8@29|Myxococcales	28221|Deltaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_868253_37	483219.LILAB_33500	3.451e-17	88.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2Z0V8@29|Myxococcales	28221|Deltaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD3_k127_868253_2	1125863.JAFN01000001_gene2554	5.842e-183	589.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HFD3_k127_868253_3	1125863.JAFN01000001_gene2556	9.918e-177	567.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,42MDX@68525|delta/epsilon subdivisions,2WJ56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HFD3_k127_868253_4	1121413.JMKT01000008_gene1526	1.139e-154	503.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,42PD3@68525|delta/epsilon subdivisions,2WJ58@28221|Deltaproteobacteria,2MATX@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05561,ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HFD3_k127_868253_26	1121459.AQXE01000005_gene1640	3.697e-29	120.0	COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,42SX0@68525|delta/epsilon subdivisions,2WP3K@28221|Deltaproteobacteria,2MC72@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM NADH-ubiquinone oxidoreductase chain 4L	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
HFD3_k127_868253_17	1121413.JMKT01000008_gene1528	1.225e-36	146.0	COG2111@1|root,COG2111@2|Bacteria,1QI9J@1224|Proteobacteria,42UJ7@68525|delta/epsilon subdivisions,2WR3F@28221|Deltaproteobacteria,2MFXV@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Na H antiporter MnhB subunit-related protein	-	-	-	-	-	-	-	-	-	-	-	-	MnhB
HFD3_k127_868253_35	1454004.AW11_02851	3.104e-20	95.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria	1224|Proteobacteria	P	Na H antiporter, MnhB	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
HFD3_k127_868253_39	1121930.AQXG01000002_gene2024	2.844e-16	81.0	COG1563@1|root,COG1563@2|Bacteria	2|Bacteria	P	Domain of unknown function (DUF4040)	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
HFD3_k127_868253_27	1304888.ATWF01000002_gene130	3.56e-26	110.0	COG1320@1|root,COG1320@2|Bacteria,2GG0R@200930|Deferribacteres	200930|Deferribacteres	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
HFD3_k127_868253_34	439235.Dalk_4918	1.453e-20	94.0	COG2212@1|root,COG2212@2|Bacteria,1N2PU@1224|Proteobacteria,42UDZ@68525|delta/epsilon subdivisions,2WQ3R@28221|Deltaproteobacteria,2MKPG@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
HFD3_k127_868253_22	477974.Daud_2168	3.917e-30	126.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
HFD3_k127_868253_7	357808.RoseRS_3609	4.199e-117	385.0	COG0530@1|root,COG0530@2|Bacteria,2G7I2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HFD3_k127_868253_42	1123060.JONP01000008_gene4561	1.246e-13	82.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_868253_12	1324957.K933_12416	7.123e-81	288.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota,23UGI@183963|Halobacteria	183963|Halobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD3_k127_868253_36	640081.Dsui_2122	1.119e-18	97.0	COG0715@1|root,COG0715@2|Bacteria,1NF3S@1224|Proteobacteria,2WEG1@28216|Betaproteobacteria,2KVYA@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HFD3_k127_868253_13	864069.MicloDRAFT_00024600	2.26e-75	272.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,1JZ35@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	dppA	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
HFD3_k127_868253_24	1005048.CFU_1567	2.877e-29	122.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2VVXU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD3_k127_868253_33	269799.Gmet_1680	2.821e-21	97.0	2CFNS@1|root,331AJ@2|Bacteria,1NBYG@1224|Proteobacteria,42VZ5@68525|delta/epsilon subdivisions,2WR8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_868253_0	1121920.AUAU01000020_gene2550	1.18e-232	727.0	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
HFD3_k127_868253_25	1122604.JONR01000025_gene4589	3.243e-29	122.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,1S9KM@1236|Gammaproteobacteria,1X7M1@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HFD3_k127_868253_9	335543.Sfum_2040	3.178e-112	370.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria,2MR1K@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD3_k127_868253_1	1123053.AUDG01000001_gene2423	2.285e-189	613.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WX1S@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_868253_11	767817.Desgi_0889	5.231e-88	297.0	COG2267@1|root,COG2267@2|Bacteria,1VDKR@1239|Firmicutes,24YIZ@186801|Clostridia,264S4@186807|Peptococcaceae	186801|Clostridia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_868253_18	314278.NB231_17323	7.08e-36	144.0	COG0454@1|root,COG0456@2|Bacteria,1NCMN@1224|Proteobacteria,1SFS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HFD3_k127_868253_19	1173263.Syn7502_03004	2.004e-35	149.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_868253_31	477184.KYC_12268	1.27e-23	109.0	COG3473@1|root,COG3473@2|Bacteria,1N3F7@1224|Proteobacteria,2VX2N@28216|Betaproteobacteria,3T53U@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Catalyzes the conversion of maleate to fumarate	-	-	4.1.1.76,5.2.1.1	ko:K01799,ko:K06033	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_868253_48	76114.p2A120	0.0002151	48.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_868253_5	1231391.AMZF01000094_gene122	3.593e-147	486.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_868253_30	1122915.AUGY01000118_gene6541	1.433e-24	115.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_868253_43	1349820.M707_14900	2.811e-12	77.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,1W8UU@1268|Micrococcaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_868253_6	331869.BAL199_08893	2.261e-132	438.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,4BQ0U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HFD3_k127_868253_46	1225184.ALXE01000020_gene2760	2.336e-06	59.0	COG0715@1|root,COG0715@2|Bacteria,1MW0S@1224|Proteobacteria,1RPE7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_868253_8	717785.HYPMC_0264	2.568e-113	382.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_868253_41	1231391.AMZF01000007_gene1511	1.278e-14	85.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2VZS3@28216|Betaproteobacteria	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_868253_16	1173263.Syn7502_03004	1.211e-45	178.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_868253_15	1231391.AMZF01000046_gene961	1.249e-54	204.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_868253_32	1343739.PAP_04900	2.836e-22	106.0	COG3473@1|root,arCOG02004@2157|Archaea,2XUJ3@28890|Euryarchaeota,24328@183968|Thermococci	183968|Thermococci	Q	Asp/Glu/Hydantoin racemase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_892635_6	1370121.AUWS01000021_gene6484	3.482e-61	214.0	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,2341D@1762|Mycobacteriaceae	201174|Actinobacteria	S	haloacid dehalogenase	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HFD3_k127_892635_29	1123504.JQKD01000031_gene4578	0.0001277	49.0	2EGFZ@1|root,33A7Y@2|Bacteria,1NI1P@1224|Proteobacteria,2VY2Y@28216|Betaproteobacteria,4AFVJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Ribosomal protein L7/L12 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L12
HFD3_k127_892635_24	56107.Cylst_5927	6.949e-09	61.0	2EC9N@1|root,33680@2|Bacteria,1G9WP@1117|Cyanobacteria,1HQ5X@1161|Nostocales	1117|Cyanobacteria	S	PFAM Ribbon-helix-helix protein, copG family	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	RHH_1
HFD3_k127_892635_23	402777.KB235898_gene5128	2.258e-13	71.0	COG3654@1|root,COG3654@2|Bacteria,1G781@1117|Cyanobacteria,1HBJW@1150|Oscillatoriales	1117|Cyanobacteria	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
HFD3_k127_892635_20	306281.AJLK01000054_gene3624	5.701e-21	93.0	COG3654@1|root,COG3654@2|Bacteria,1G781@1117|Cyanobacteria,1JJ3W@1189|Stigonemataceae	1117|Cyanobacteria	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
HFD3_k127_892635_0	1231391.AMZF01000094_gene122	1.653e-176	571.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_892635_3	1411123.JQNH01000001_gene964	1.427e-87	293.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	MA20_22025	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HFD3_k127_892635_7	1121106.JQKB01000005_gene2136	4.48e-61	226.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,2JQSE@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_892635_15	1231391.AMZF01000003_gene3114	1.626e-43	172.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_892635_1	479434.Sthe_1452	2.729e-139	458.0	COG1053@1|root,COG1053@2|Bacteria,2GA4Y@200795|Chloroflexi,27Z93@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD binding domain	-	-	1.3.99.4	ko:K05898,ko:K13796	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09884	RC00991	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
HFD3_k127_892635_12	710686.Mycsm_01832	1.039e-49	190.0	COG2358@1|root,COG2358@2|Bacteria,2I9QR@201174|Actinobacteria	201174|Actinobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HFD3_k127_892635_2	675635.Psed_3034	9.573e-123	410.0	COG5016@1|root,COG5016@2|Bacteria,2IA4P@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HFD3_k127_892635_8	211165.AJLN01000047_gene6187	1.535e-60	215.0	COG0259@1|root,COG0259@2|Bacteria,1G0HC@1117|Cyanobacteria,1JHDR@1189|Stigonemataceae	1117|Cyanobacteria	H	Pfam:PNPOx_C	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
HFD3_k127_892635_27	13349.G1WY37	2.729e-05	53.0	COG2940@1|root,KOG1079@2759|Eukaryota,38DMC@33154|Opisthokonta,3NZVU@4751|Fungi,3QKMA@4890|Ascomycota	4751|Fungi	K	Set domain-containing protein	-	-	2.1.1.43	ko:K11430	ko00310,ko05206,map00310,map05206	-	R03875,R03938,R04866,R04867	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000,ko03036	-	-	-	SET
HFD3_k127_892635_11	1047013.AQSP01000073_gene1091	9.401e-51	196.0	COG1600@1|root,COG1600@2|Bacteria,2NQCR@2323|unclassified Bacteria	2|Bacteria	C	Reductive dehalogenase subunit	cprA	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4,Fer4_7
HFD3_k127_892635_17	525904.Tter_0600	4.243e-32	128.0	COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7
HFD3_k127_892635_5	1231391.AMZF01000046_gene961	6.727e-64	233.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_892635_13	903818.KI912268_gene2069	1.675e-49	192.0	COG1600@1|root,COG1600@2|Bacteria,3Y7GB@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_7
HFD3_k127_892635_16	1231391.AMZF01000069_gene2126	2.132e-39	160.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_892635_14	903818.KI912268_gene2069	1.901e-49	193.0	COG1600@1|root,COG1600@2|Bacteria,3Y7GB@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_7
HFD3_k127_892635_21	1123376.AUIU01000014_gene616	8.822e-20	94.0	2EK9R@1|root,33E01@2|Bacteria,3J1B5@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_892635_10	1041146.ATZB01000008_gene2208	1.779e-55	202.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,4B7AF@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	dienelactone hydrolase	dlhH	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD3_k127_892635_22	1125863.JAFN01000001_gene2755	2.024e-19	92.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD3_k127_892635_25	1144342.PMI40_00606	9.535e-09	66.0	COG0715@1|root,COG0715@2|Bacteria,1N40U@1224|Proteobacteria,2VKYC@28216|Betaproteobacteria,4761I@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HFD3_k127_892635_28	926550.CLDAP_38470	5.963e-05	48.0	COG2141@1|root,COG2141@2|Bacteria,2G5MF@200795|Chloroflexi	200795|Chloroflexi	C	PFAM luciferase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_892635_19	172088.AUGA01000026_gene258	1.654e-23	109.0	COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TUEF@28211|Alphaproteobacteria,3JT5U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	MA20_15005	-	4.1.1.79	ko:K13039	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD3_k127_892635_18	1382306.JNIM01000001_gene3715	5.348e-29	124.0	COG4032@1|root,COG4032@2|Bacteria,2G8KU@200795|Chloroflexi	200795|Chloroflexi	S	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.79	ko:K06034	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
HFD3_k127_892635_9	443152.MDG893_15295	1.003e-55	207.0	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HFD3_k127_892635_4	1267535.KB906767_gene4415	8.165e-73	252.0	COG1044@1|root,COG1044@2|Bacteria,3Y6ZT@57723|Acidobacteria	57723|Acidobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HFD3_k127_894942_4	420324.KI911999_gene8064	3.36e-42	155.0	28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_894942_7	1121456.ATVA01000005_gene2980	1.633e-11	76.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42UZS@68525|delta/epsilon subdivisions,2X77T@28221|Deltaproteobacteria,2MA9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15551	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	NMT1,NMT1_2
HFD3_k127_894942_6	861299.J421_2404	3.322e-13	77.0	2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_894942_2	1231391.AMZF01000110_gene916	4.975e-237	746.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_894942_1	1231391.AMZF01000110_gene916	2.302e-242	761.0	COG0028@1|root,COG0028@2|Bacteria,1MX3Q@1224|Proteobacteria,2VMUI@28216|Betaproteobacteria,3T2PP@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_894942_3	316067.Geob_2921	1.868e-181	579.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,43T78@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD3_k127_894942_0	1047013.AQSP01000138_gene1021	1.004e-286	889.0	COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
HFD3_k127_894942_5	880073.Calab_1642	7.781e-32	140.0	COG2067@1|root,COG2067@2|Bacteria,2NPN1@2323|unclassified Bacteria	2|Bacteria	I	Membrane protein involved in aromatic hydrocarbon degradation	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HFD3_k127_894942_8	1198114.AciX9_1892	2.599e-11	66.0	COG3311@1|root,COG3311@2|Bacteria,3Y83X@57723|Acidobacteria,2JN8A@204432|Acidobacteriia	204432|Acidobacteriia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HFD3_k127_898591_4	903818.KI912269_gene527	2.04e-12	76.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183,2.3.1.82	ko:K03823,ko:K18816	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	br01600,ko00000,ko00001,ko01000,ko01504	-	-	-	Acetyltransf_1,Methyltransf_25
HFD3_k127_898591_5	1216932.CM240_3140	5.728e-11	68.0	COG1917@1|root,COG1917@2|Bacteria,1UNPD@1239|Firmicutes	1239|Firmicutes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_898591_2	443598.AUFA01000004_gene5490	2.227e-55	204.0	COG0491@1|root,COG0491@2|Bacteria,1PPPW@1224|Proteobacteria,2U30I@28211|Alphaproteobacteria,3JX0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_898591_0	266117.Rxyl_0146	4.179e-255	807.0	COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4CQ1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HFD3_k127_898591_1	1123023.JIAI01000004_gene7873	1.947e-59	221.0	COG0006@1|root,COG0006@2|Bacteria,2IAJ8@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HFD3_k127_901370_0	1381123.AYOD01000015_gene2538	1.16e-135	440.0	COG0683@1|root,COG0683@2|Bacteria,1MV3Y@1224|Proteobacteria,2TU2B@28211|Alphaproteobacteria,43HZY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	MA20_07775	-	-	ko:K01999,ko:K11959	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_6
HFD3_k127_901370_3	296591.Bpro_2639	6.66e-107	356.0	COG1917@1|root,COG1917@2|Bacteria,1RH0Y@1224|Proteobacteria,2VWWA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_901370_6	517418.Ctha_2407	4.886e-35	142.0	COG0400@1|root,COG0400@2|Bacteria,1FE1K@1090|Chlorobi	1090|Chlorobi	S	PFAM phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
HFD3_k127_901370_2	177437.HRM2_33680	5.248e-107	367.0	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
HFD3_k127_901370_4	1499967.BAYZ01000152_gene1432	1.949e-86	292.0	COG1131@1|root,COG1131@2|Bacteria,2NPDQ@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	natA2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD3_k127_901370_5	177437.HRM2_33700	8.287e-71	258.0	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HFD3_k127_901370_7	1379698.RBG1_1C00001G0559	7.062e-30	126.0	COG1656@1|root,COG1656@2|Bacteria,2NPUJ@2323|unclassified Bacteria	2|Bacteria	H	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HFD3_k127_901370_1	1051632.TPY_2012	2.346e-121	415.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WD5H@538999|Clostridiales incertae sedis	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HFD3_k127_92632_2	484770.UFO1_2870	2.13e-112	381.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	60KD_IMP,PEP-utilizers,PPDK_N,Rhodanese,YceI
HFD3_k127_92632_3	1380394.JADL01000003_gene4824	6.97e-23	110.0	COG0329@1|root,COG0329@2|Bacteria,1MWAH@1224|Proteobacteria,2TSXX@28211|Alphaproteobacteria,2JS0U@204441|Rhodospirillales	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	dapAch4	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD3_k127_92632_0	1123073.KB899243_gene722	1.952e-143	466.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RMY2@1236|Gammaproteobacteria,1XDBK@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_92632_1	1123073.KB899243_gene722	9.354e-133	435.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RMY2@1236|Gammaproteobacteria,1XDBK@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HFD3_k127_926770_5	105559.Nwat_1755	9.699e-27	113.0	COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,1RN11@1236|Gammaproteobacteria,1WXWW@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4
HFD3_k127_926770_4	314278.NB231_08222	1.227e-75	270.0	COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,1RPTR@1236|Gammaproteobacteria,1X25Y@135613|Chromatiales	135613|Chromatiales	M	Wzy family polymerase, exosortase system type 1 associated	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HFD3_k127_926770_0	338969.Rfer_0671	1.479e-203	651.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,4A9JC@80864|Comamonadaceae	28216|Betaproteobacteria	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD3_k127_926770_2	62928.azo3270	5.465e-112	375.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2VJT7@28216|Betaproteobacteria,2KUCI@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyl transferases group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD3_k127_926770_7	1499967.BAYZ01000102_gene3573	2.996e-18	101.0	COG3979@1|root,COG3979@2|Bacteria	2|Bacteria	S	chitin catabolic process	chiA	GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005623,GO:0008843,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.14,3.2.1.17	ko:K01183,ko:K03933,ko:K13381	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	AA10,CBM15,CBM73,GH18	-	CBM_5_12,DUF5011,LPMO_10,Peptidase_M60
HFD3_k127_926770_6	215803.DB30_3127	6.943e-21	109.0	COG4733@1|root,COG5434@1|root,COG4733@2|Bacteria,COG5434@2|Bacteria,1QX65@1224|Proteobacteria,43BYR@68525|delta/epsilon subdivisions,2X79M@28221|Deltaproteobacteria	2|Bacteria	G	Fibronectin type 3 domain	celN	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Cadherin-like,Cellulase,Esterase_phd,F5_F8_type_C,Glyco_hydro_8,Pectate_lyase_3,RicinB_lectin_2,SLH,fn3
HFD3_k127_926770_1	1117958.PE143B_0117405	9.968e-149	482.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RPAC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD3_k127_926770_3	357808.RoseRS_2395	2.838e-104	347.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD3_k127_933044_5	1191523.MROS_1383	5.68e-47	172.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HFD3_k127_933044_0	1232410.KI421413_gene866	3.943e-203	663.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,42PST@68525|delta/epsilon subdivisions,2WJ3A@28221|Deltaproteobacteria,43SDH@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PEP-utilising enzyme, N-terminal	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HFD3_k127_933044_2	1380386.JIAW01000004_gene71	1.086e-62	230.0	COG3396@1|root,COG3396@2|Bacteria,2GK2T@201174|Actinobacteria,23CT4@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phenylacetate-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD3_k127_933044_7	1209989.TepiRe1_2034	2.211e-16	82.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HFD3_k127_933044_1	771875.Ferpe_1116	4.694e-106	357.0	COG1894@1|root,COG1894@2|Bacteria,2GCCH@200918|Thermotogae	200918|Thermotogae	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HFD3_k127_933044_4	1231391.AMZF01000046_gene961	1.949e-59	218.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_933044_3	1123023.JIAI01000018_gene2484	8.098e-60	218.0	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria,4EC9Z@85010|Pseudonocardiales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HFD3_k127_933044_6	1231391.AMZF01000046_gene961	5.176e-28	126.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_938835_4	1040989.AWZU01000011_gene4024	7.475e-78	265.0	COG2085@1|root,COG2085@2|Bacteria,1MV62@1224|Proteobacteria,2TVDG@28211|Alphaproteobacteria,3JUPR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
HFD3_k127_938835_10	887325.HMPREF0381_2174	2.789e-34	138.0	COG1859@1|root,COG1859@2|Bacteria,1V49Y@1239|Firmicutes,24H56@186801|Clostridia	186801|Clostridia	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
HFD3_k127_938835_8	742735.HMPREF9467_03493	4.754e-38	154.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,21YRM@1506553|Lachnoclostridium	186801|Clostridia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD3_k127_938835_12	1123053.AUDG01000038_gene348	4.108e-07	57.0	COG3806@1|root,COG3806@2|Bacteria,1RI6T@1224|Proteobacteria,1S341@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	AntiSigma factor	chrR	-	-	ko:K07167	-	-	-	-	ko00000	-	-	-	Cupin_7
HFD3_k127_938835_1	640081.Dsui_3023	2.823e-121	398.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,2KVRY@206389|Rhodocyclales	206389|Rhodocyclales	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD3_k127_938835_7	338963.Pcar_0729	1.564e-39	151.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,43V08@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HFD3_k127_938835_0	316067.Geob_3599	3.317e-131	427.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,43TN3@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HFD3_k127_938835_3	880072.Desac_1429	1.145e-89	301.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MRHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HFD3_k127_938835_5	1507.HMPREF0262_02909	5.57e-55	196.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,36HZA@31979|Clostridiaceae	186801|Clostridia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HFD3_k127_938835_6	56780.SYN_01598	4.308e-49	177.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MRU2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HFD3_k127_938835_11	1303518.CCALI_02887	3.416e-12	68.0	COG0257@1|root,COG0257@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HFD3_k127_938835_9	1162668.LFE_0905	8.283e-35	134.0	COG0361@1|root,COG0361@2|Bacteria,3J0QB@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HFD3_k127_938835_2	644282.Deba_2916	2.789e-92	310.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HFD3_k127_939158_1	797299.HALLA_02515	3.133e-56	203.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAS@28890|Euryarchaeota,23SVB@183963|Halobacteria	183963|Halobacteria	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HFD3_k127_939158_5	323261.Noc_1063	0.0005883	50.0	COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,1S0ET@1236|Gammaproteobacteria	1236|Gammaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_19,TonB_dep_Rec
HFD3_k127_939158_4	1343740.M271_30775	1.66e-10	71.0	COG3473@1|root,COG3473@2|Bacteria,2GKP7@201174|Actinobacteria	201174|Actinobacteria	Q	Maleate cis-trans isomerase	-	-	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_Glu_race
HFD3_k127_939158_0	1198232.CYCME_2222	1.89e-128	419.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,460KK@72273|Thiotrichales	72273|Thiotrichales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD3_k127_939158_3	45130.XP_007706029.1	2.459e-16	83.0	COG1917@1|root,2SGK2@2759|Eukaryota,3A3ZH@33154|Opisthokonta,3P3Y2@4751|Fungi,3QWGD@4890|Ascomycota,202Z4@147541|Dothideomycetes	4751|Fungi	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD3_k127_939158_2	1487923.DP73_05065	3.1e-20	98.0	COG0778@1|root,COG0778@2|Bacteria,1V2ST@1239|Firmicutes,25BCB@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD3_k127_949234_0	1380394.JADL01000001_gene2482	1.235e-123	411.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HFD3_k127_949234_1	1231391.AMZF01000003_gene3114	7.595e-38	154.0	COG1840@1|root,COG1840@2|Bacteria,1MY20@1224|Proteobacteria,2VJ69@28216|Betaproteobacteria,3T4Q9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HFD3_k127_952450_2	1128421.JAGA01000003_gene2941	2.056e-45	175.0	COG0346@1|root,COG0346@2|Bacteria,2NRR7@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HFD3_k127_952450_0	479434.Sthe_3115	4.247e-81	282.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD3_k127_952450_3	1392498.JQLH01000001_gene1807	2.567e-41	164.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HFD3_k127_952450_4	266264.Rmet_5200	7.747e-15	80.0	COG0346@1|root,COG0346@2|Bacteria,1QVY4@1224|Proteobacteria,2VY37@28216|Betaproteobacteria,1K58Q@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD3_k127_952450_1	1131730.BAVI_13169	1.477e-47	178.0	COG1917@1|root,COG1917@2|Bacteria,1V0SF@1239|Firmicutes,4HA58@91061|Bacilli,1ZEI3@1386|Bacillus	91061|Bacilli	S	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate	nbaC	-	1.13.11.6	ko:K00452	ko00380,ko01100,map00380,map01100	M00038	R02665	RC00387	ko00000,ko00001,ko00002,ko01000	-	-	-	3-HAO
HFD3_k127_957136_5	1380394.JADL01000011_gene3995	9.71e-49	186.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,2JSE3@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HFD3_k127_957136_1	543728.Vapar_4004	6.189e-139	454.0	COG3391@1|root,COG3794@1|root,COG3391@2|Bacteria,COG3794@2|Bacteria,1P862@1224|Proteobacteria,2VM1W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HFD3_k127_957136_8	1449126.JQKL01000049_gene2636	1.637e-15	85.0	COG2865@1|root,COG2865@2|Bacteria,1VXMB@1239|Firmicutes,256SQ@186801|Clostridia	186801|Clostridia	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
HFD3_k127_957136_10	742767.HMPREF9456_03126	5.471e-07	52.0	COG2865@1|root,COG2865@2|Bacteria,4NSI5@976|Bacteroidetes,2FYKB@200643|Bacteroidia,2312J@171551|Porphyromonadaceae	976|Bacteroidetes	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2
HFD3_k127_957136_0	1288494.EBAPG3_4650	1.29e-189	602.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2VKYD@28216|Betaproteobacteria,37424@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_957136_6	1192034.CAP_1637	3.448e-48	177.0	COG4319@1|root,COG4319@2|Bacteria,1N40J@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase,SnoaL_3
HFD3_k127_957136_9	479434.Sthe_2955	3.26e-14	74.0	COG4941@1|root,COG4941@2|Bacteria,2G84R@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD3_k127_957136_3	1254432.SCE1572_37995	5.793e-68	233.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,439P5@68525|delta/epsilon subdivisions,2X50M@28221|Deltaproteobacteria,2YZXZ@29|Myxococcales	28221|Deltaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD3_k127_957136_4	1411123.JQNH01000001_gene807	3.016e-60	211.0	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2U5A4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HFD3_k127_957136_2	1266925.JHVX01000007_gene2418	2.673e-78	268.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,374MK@32003|Nitrosomonadales	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HFD3_k127_957136_7	63737.Npun_R2131	3.295e-23	104.0	COG3795@1|root,COG3795@2|Bacteria,1G6M3@1117|Cyanobacteria,1HSFT@1161|Nostocales	1117|Cyanobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD3_k127_960858_10	243231.GSU2064	2.747e-72	256.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
HFD3_k127_960858_8	316067.Geob_3461	1.266e-74	261.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,43SZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD3_k127_960858_14	760568.Desku_2263	9.617e-62	224.0	COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,24AGQ@186801|Clostridia,262B2@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
HFD3_k127_960858_9	1444306.JFZC01000041_gene50	1.768e-72	252.0	COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,4HC3N@91061|Bacilli,26NPU@186821|Sporolactobacillaceae	91061|Bacilli	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
HFD3_k127_960858_12	926554.KI912637_gene3408	1.803e-64	235.0	COG3221@1|root,COG3221@2|Bacteria,1WIG6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HFD3_k127_960858_18	1396418.BATQ01000019_gene4981	3.281e-26	119.0	COG0457@1|root,COG0457@2|Bacteria,46VTD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_960858_16	391625.PPSIR1_04398	3.387e-32	128.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,42RJS@68525|delta/epsilon subdivisions,2WQSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HFD3_k127_960858_4	526222.Desal_2437	5.294e-132	427.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD3_k127_960858_17	1131269.AQVV01000038_gene1564	3.081e-27	114.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD3_k127_960858_20	1499967.BAYZ01000047_gene2731	1.076e-10	70.0	COG0248@1|root,COG0248@2|Bacteria,2NPR1@2323|unclassified Bacteria	2|Bacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD3_k127_960858_15	1499967.BAYZ01000047_gene2731	1.364e-58	222.0	COG0248@1|root,COG0248@2|Bacteria,2NPR1@2323|unclassified Bacteria	2|Bacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD3_k127_960858_1	358681.BBR47_34910	8.731e-152	492.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,4HB27@91061|Bacilli,26QW5@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HFD3_k127_960858_0	502025.Hoch_4636	4.402e-267	843.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2YU14@29|Myxococcales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HFD3_k127_960858_7	56780.SYN_02797	4.471e-87	303.0	COG0758@1|root,COG4277@1|root,COG0758@2|Bacteria,COG4277@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MQD6@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD3_k127_960858_3	316067.Geob_2156	1.85e-133	441.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,43U5B@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD3_k127_960858_5	269799.Gmet_2315	8.92e-97	325.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2WJC8@28221|Deltaproteobacteria,43TV2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HFD3_k127_960858_19	1459636.NTE_02734	1.51e-14	81.0	arCOG11830@1|root,arCOG11830@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_960858_2	1499967.BAYZ01000095_gene4241	2.183e-145	510.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	GATase1_like,VWA,VWA_2,VWA_3
HFD3_k127_960858_6	1499967.BAYZ01000095_gene4251	1.119e-88	332.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HFD3_k127_960858_11	502025.Hoch_3262	1.862e-66	239.0	COG1721@1|root,COG1721@2|Bacteria,1NEAC@1224|Proteobacteria,43B78@68525|delta/epsilon subdivisions,2X6KP@28221|Deltaproteobacteria,2YWA8@29|Myxococcales	28221|Deltaproteobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HFD3_k127_960858_13	1499967.BAYZ01000095_gene4253	3.713e-63	222.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HFD3_k127_969975_1	693986.MOC_0079	5.443e-118	393.0	COG2223@1|root,COG2223@2|Bacteria,1QU76@1224|Proteobacteria,2TXBE@28211|Alphaproteobacteria,1JZIX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD3_k127_969975_2	1120949.KB903301_gene6368	6.209e-96	335.0	COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4DJNV@85008|Micromonosporales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD3_k127_969975_5	1463857.JOFZ01000007_gene160	1.185e-13	82.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HFD3_k127_969975_6	357808.RoseRS_0654	0.0008996	43.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_969975_4	28072.Nos7524_4685	1.009e-21	100.0	COG2442@1|root,COG2442@2|Bacteria,1GA44@1117|Cyanobacteria,1HPUY@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HFD3_k127_969975_3	420324.KI912063_gene6711	4.334e-44	179.0	COG2202@1|root,COG3275@1|root,COG3920@1|root,COG2202@2|Bacteria,COG3275@2|Bacteria,COG3920@2|Bacteria,1R8KX@1224|Proteobacteria,2U4YS@28211|Alphaproteobacteria,1JYYZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_9
HFD3_k127_969975_0	266265.Bxe_C1059	1.219e-160	522.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria,1K3N4@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HFD3_k127_971319_9	1499967.BAYZ01000003_gene5836	1.199e-23	109.0	COG0457@1|root,COG3577@1|root,COG0457@2|Bacteria,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	Asp_protease_2,TPR_19,gag-asp_proteas
HFD3_k127_971319_7	1125863.JAFN01000001_gene1434	4.01e-31	124.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD3_k127_971319_1	269799.Gmet_1591	7.153e-271	851.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HFD3_k127_971319_4	269799.Gmet_1592	7.022e-121	402.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,43TZJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD3_k127_971319_6	56780.SYN_01779	4.63e-48	177.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,42SJS@68525|delta/epsilon subdivisions,2WP7N@28221|Deltaproteobacteria,2MRZ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	dUTPase	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD3_k127_971319_3	443144.GM21_1887	1.142e-175	560.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD3_k127_971319_8	1117108.PAALTS15_03942	1.714e-24	104.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,26Z31@186822|Paenibacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
HFD3_k127_971319_5	518766.Rmar_2306	1.234e-85	290.0	COG0047@1|root,COG0047@2|Bacteria,4NFER@976|Bacteroidetes,1FIWZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD3_k127_971319_0	330214.NIDE1392	4.059e-290	909.0	COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HFD3_k127_971319_2	1382359.JIAL01000001_gene1757	5.156e-178	569.0	COG0034@1|root,COG0034@2|Bacteria,3Y3RG@57723|Acidobacteria,2JHXM@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HFD3_k127_971464_5	1304888.ATWF01000001_gene961	1.931e-09	60.0	COG0413@1|root,COG0413@2|Bacteria,2GF51@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD3_k127_971464_0	485915.Dret_2298	3.194e-184	590.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MDPJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
HFD3_k127_971464_4	485915.Dret_0882	4.445e-11	66.0	2DD8W@1|root,2ZH3F@2|Bacteria,1PBGJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD3_k127_971464_1	266779.Meso_2926	8.568e-181	579.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,43KZ3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HFD3_k127_971464_2	525897.Dbac_1841	3.446e-94	322.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HFD3_k127_971464_3	1380386.JIAW01000030_gene3590	3.86e-28	115.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,2392Z@1762|Mycobacteriaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1,SBP_bac_6
HFD3_k127_975398_5	667632.KB890165_gene2433	2.953e-35	141.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2VMT6@28216|Betaproteobacteria,1K1MZ@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD3_k127_975398_1	404380.Gbem_1836	5.91e-54	211.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,42PA6@68525|delta/epsilon subdivisions,2WIIY@28221|Deltaproteobacteria,43U88@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Pilus formation protein N terminal region	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD3_k127_975398_2	335543.Sfum_1497	4.449e-49	191.0	COG4565@1|root,COG4963@1|root,COG4565@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MQ4X@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
HFD3_k127_975398_0	443143.GM18_2435	2.075e-172	552.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,43SA4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
HFD3_k127_975398_4	485915.Dret_1160	9.986e-42	168.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,42QS0@68525|delta/epsilon subdivisions,2WMU6@28221|Deltaproteobacteria,2M8XP@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Type II secretion system F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD3_k127_975398_3	207559.Dde_2365	1.882e-45	176.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MAZ8@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM Type II secretion system F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD3_k127_975398_6	401526.TcarDRAFT_1917	1.492e-21	98.0	COG1430@1|root,COG1430@2|Bacteria,1VF55@1239|Firmicutes,4H5P7@909932|Negativicutes	909932|Negativicutes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD3_k127_996538_3	278963.ATWD01000001_gene1850	1.859e-46	174.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_996538_1	1121430.JMLG01000002_gene1079	3.51e-54	200.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,26121@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD3_k127_996538_4	1218352.B597_020855	3.609e-33	141.0	COG0715@1|root,COG0715@2|Bacteria,1Q6YX@1224|Proteobacteria,1TA09@1236|Gammaproteobacteria,1Z3Z7@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HFD3_k127_996538_2	402881.Plav_0389	2.219e-51	194.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD3_k127_996538_0	404589.Anae109_1864	5.064e-147	473.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2YV6M@29|Myxococcales	28221|Deltaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284,ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4	-	-	CorA
HFD3_k127_996538_5	298653.Franean1_3135	1.117e-20	98.0	COG1024@1|root,COG1024@2|Bacteria,2H793@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
## 4772 queries scanned
## Total time (seconds): 426.0946695804596
## Rate: 11.20 q/s