## Fri Nov 15 09:41:11 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_1_bin.49.fa -m mmseqs --itype genome -o HKD_1_bin.49 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_1_bin.49 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1002531_2	1267005.KB911264_gene3188	6.356e-40	165.0	COG5342@1|root,COG5342@2|Bacteria,1MV8Y@1224|Proteobacteria,2TS6A@28211|Alphaproteobacteria,3N7DB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Invasion associated locus B (IalB) protein	MA20_13025	-	-	-	-	-	-	-	-	-	-	-	IalB
HKD1_k127_1002531_0	717785.HYPMC_1938	6.78e-259	810.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N86I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	nikA	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_1002531_1	717785.HYPMC_1937	6.227e-117	392.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,3N7KU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_1020122_8	1267005.KB911256_gene1494	1.513e-72	250.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,3N6UI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_1020122_6	717785.HYPMC_0938	7.031e-90	304.0	COG5465@1|root,COG5465@2|Bacteria,1REC1@1224|Proteobacteria,2U7UP@28211|Alphaproteobacteria,3N6S4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative bacterial sensory transduction regulator	MA20_05485	-	-	-	-	-	-	-	-	-	-	-	YbjN
HKD1_k127_1020122_11	1267005.KB911256_gene1492	8.397e-26	112.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,3N7EF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Membrane fusogenic activity	MA20_05375	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD1_k127_1020122_1	1267005.KB911256_gene1491	3.098e-123	402.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,3N6RC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_1020122_2	1267005.KB911256_gene1490	5.342e-112	385.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,3N6U6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	MA20_05390	-	2.1.1.79	ko:K00574,ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03029	-	-	-	Methyltransf_28
HKD1_k127_1020122_5	582899.Hden_2506	2.821e-92	309.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,3N6SZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_1020122_3	1267005.KB911256_gene1488	5.434e-97	329.0	2E5ZA@1|root,330NT@2|Bacteria,1NDA4@1224|Proteobacteria,2UG06@28211|Alphaproteobacteria,3N8QV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1020122_0	717785.HYPMC_0932	4.964e-171	549.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,3N64F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD1_k127_1020122_10	1267005.KB911256_gene1449	1.516e-53	195.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,3N72X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	zur	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
HKD1_k127_1020122_7	1267005.KB911256_gene1450	1.195e-85	301.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,3N6UA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD1_k127_1020122_4	582899.Hden_2513	4.802e-95	317.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,3N6TR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_1020122_9	626418.bglu_2g05600	2.196e-59	209.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VM20@28216|Betaproteobacteria,1K1DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	PFAM ABC transporter related	hndI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1041687_1	1170562.Cal6303_4456	6.362e-248	791.0	COG2303@1|root,COG4757@1|root,COG2303@2|Bacteria,COG4757@2|Bacteria,1G5DG@1117|Cyanobacteria,1HRGW@1161|Nostocales	1117|Cyanobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD1_k127_1041687_3	1192868.CAIU01000007_gene696	2.788e-43	164.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2U57Q@28211|Alphaproteobacteria,43JXP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_1041687_4	1279038.KB907341_gene1762	7.656e-22	96.0	2E4CR@1|root,32Z86@2|Bacteria,1N7UZ@1224|Proteobacteria,2UF9N@28211|Alphaproteobacteria,2JUJJ@204441|Rhodospirillales	204441|Rhodospirillales	S	NADH-dependant formate dehydrogenase delta subunit FdsD	-	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
HKD1_k127_1041687_2	717785.HYPMC_0974	3.013e-95	320.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2TUD2@28211|Alphaproteobacteria,3N8I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD1_k127_1041687_0	717785.HYPMC_0975	0.0	1131.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,3N9IP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_1048980_4	557599.MKAN_04810	4.633e-52	196.0	COG0412@1|root,COG0412@2|Bacteria,2ISE7@201174|Actinobacteria,23B25@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	SnoaL_2
HKD1_k127_1048980_5	1044.EH31_16000	6.098e-31	124.0	COG1122@1|root,COG1122@2|Bacteria,1QTSC@1224|Proteobacteria,2TUFZ@28211|Alphaproteobacteria,2K90A@204457|Sphingomonadales	204457|Sphingomonadales	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
HKD1_k127_1048980_1	94624.Bpet4630	1.778e-106	363.0	COG0497@1|root,COG0497@2|Bacteria,1QUWK@1224|Proteobacteria,2WGWH@28216|Betaproteobacteria	28216|Betaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
HKD1_k127_1048980_3	1044.EH31_16000	6.94e-63	228.0	COG1122@1|root,COG1122@2|Bacteria,1QTSC@1224|Proteobacteria,2TUFZ@28211|Alphaproteobacteria,2K90A@204457|Sphingomonadales	204457|Sphingomonadales	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
HKD1_k127_1048980_0	1267005.KB911260_gene3517	0.0	1729.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3N68D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_1048980_2	395964.KE386496_gene2369	1.619e-94	315.0	COG0625@1|root,COG0625@2|Bacteria,1MX33@1224|Proteobacteria,2TV9R@28211|Alphaproteobacteria,3NC1H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase N-terminal domain	MA20_18730	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_C_6,GST_N_4
HKD1_k127_1049639_4	670307.HYPDE_30483	2.151e-18	86.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3N6J2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_1049639_1	1267005.KB911258_gene593	1.006e-82	295.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,3N6ZA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_1049639_0	1267005.KB911258_gene594	2.748e-83	286.0	28MUE@1|root,2ZB2B@2|Bacteria,1N3YU@1224|Proteobacteria,2TUD9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD1_k127_1049639_3	1267005.KB911258_gene595	5.838e-38	143.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,3N72K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_1049639_2	1267005.KB911258_gene596	1.101e-60	216.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,3N6ZP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_1050250_2	1267005.KB911255_gene3028	9.222e-111	364.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,3N6MW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	ptr1	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_1050250_1	670307.HYPDE_28473	1.468e-121	404.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	-	-	3.5.1.28	ko:K01448,ko:K02395,ko:K17733	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036	-	-	-	Amidase_2,Amidase_3,CotH,Glucosaminidase,Peptidase_M15_4,Rod-binding
HKD1_k127_1050250_3	1267005.KB911255_gene3030	3.581e-86	305.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD1_k127_1050250_0	648757.Rvan_3167	4.525e-152	489.0	COG1215@1|root,COG1215@2|Bacteria,1PC79@1224|Proteobacteria,2TU2P@28211|Alphaproteobacteria,3N7S2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	ugcG	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HKD1_k127_1050250_4	1267005.KB911255_gene3031	6.14e-71	245.0	28W98@1|root,2ZI9R@2|Bacteria,1NQ3G@1224|Proteobacteria,2TT2E@28211|Alphaproteobacteria,3N8E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1057196_3	582899.Hden_3175	1.096e-110	366.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD1_k127_1057196_0	1267005.KB911259_gene3837	7.94e-285	881.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSK4@28211|Alphaproteobacteria,3N6IZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	MA20_26350	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_1057196_1	1267005.KB911259_gene3834	3.74e-222	699.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,3N67Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD1_k127_1057196_4	670307.HYPDE_31028	3.394e-109	364.0	2CKRE@1|root,32SCW@2|Bacteria,1MWRU@1224|Proteobacteria,2TSRM@28211|Alphaproteobacteria,3N7FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2865
HKD1_k127_1057196_5	157783.LK03_17415	6.684e-12	73.0	COG0454@1|root,COG0456@2|Bacteria,1RI07@1224|Proteobacteria,1S7S4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_1057196_2	1267005.KB911259_gene3832	2.162e-159	508.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,3N6JF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_1066410_6	670307.HYPDE_41403	1.152e-71	244.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,3N723@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_1066410_5	1267005.KB911257_gene994	8.423e-85	289.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,3N7U9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_1066410_7	1267005.KB911257_gene995	1.251e-63	224.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,3N8J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pfam:TPM	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_1066410_1	1267005.KB911257_gene920	8.41e-188	598.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major facilitator superfamily	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD1_k127_1066410_0	717785.HYPMC_4802	7.179e-239	749.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,3N6HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD1_k127_1066410_2	1267005.KB911257_gene923	2.31e-179	580.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,3N6YX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Heparinase II/III-like protein	MA20_25080	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
HKD1_k127_1066410_3	1267005.KB911257_gene924	5.473e-143	460.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,3N6F7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD1_k127_1091617_9	1382359.JIAL01000001_gene1241	9.268e-42	159.0	COG3115@1|root,COG3115@2|Bacteria,3Y6JB@57723|Acidobacteria,2JK9E@204432|Acidobacteriia	204432|Acidobacteriia	D	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD1_k127_1091617_1	670307.HYPDE_24908	0.0	1054.0	COG4258@1|root,COG4258@2|Bacteria,1QW57@1224|Proteobacteria,2TSFU@28211|Alphaproteobacteria,3N7TH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Hopanoid biosynthesis associated RND transporter like protein HpnN	MA20_16030	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD1_k127_1091617_4	717785.HYPMC_3768	1.072e-145	466.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,3N7TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD1_k127_1091617_2	582899.Hden_0479	8.453e-223	694.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,2TT7D@28211|Alphaproteobacteria,3N7VZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Hopanoid biosynthesis associated radical SAM protein HpnH	MA20_16040	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_1091617_10	93220.LV28_21720	2.922e-38	154.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,2VX38@28216|Betaproteobacteria,1K1N8@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
HKD1_k127_1091617_0	670307.HYPDE_24888	0.0	1076.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2TRF3@28211|Alphaproteobacteria,3N867@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Squalene-hopene cyclase C-terminal domain	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD1_k127_1091617_3	670307.HYPDE_24883	1.162e-166	540.0	COG1233@1|root,COG1233@2|Bacteria,1QU52@1224|Proteobacteria,2TW02@28211|Alphaproteobacteria,3N8AG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	amine oxidase	MA20_16055	-	1.17.8.1	ko:K21677	-	-	-	-	ko00000,ko01000	-	-	-	Amino_oxidase
HKD1_k127_1091617_7	977880.RALTA_B1982	5.222e-89	311.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VMRA@28216|Betaproteobacteria,1K02E@119060|Burkholderiaceae	28216|Betaproteobacteria	I	phytoene synthase	-	-	2.5.1.103	ko:K21678	-	-	-	-	ko00000,ko01000	-	-	-	SQS_PSY
HKD1_k127_1091617_6	582899.Hden_0474	3.472e-101	345.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2TT8U@28211|Alphaproteobacteria,3N7MH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	squalene synthase HpnC	hpnC	-	2.5.1.103,4.2.3.156	ko:K21678,ko:K21679	-	-	-	-	ko00000,ko01000	-	-	-	SQS_PSY
HKD1_k127_1091617_5	582899.Hden_0473	5.698e-140	460.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,2U30S@28211|Alphaproteobacteria,3N88D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Hopene-associated glycosyltransferase HpnB	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HKD1_k127_1091617_8	999541.bgla_2g29050	4.416e-81	273.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2VIQ7@28216|Betaproteobacteria,1K2DE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD1_k127_109326_1	652103.Rpdx1_2636	4.46e-127	412.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,3JS9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_109326_5	582899.Hden_1672	1.717e-31	126.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	MA20_41765	-	-	-	-	-	-	-	-	-	-	-	DivIC
HKD1_k127_109326_0	670307.HYPDE_30658	2.2e-228	716.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,3N69K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_109326_4	670307.HYPDE_30663	2.166e-48	178.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2UBRG@28211|Alphaproteobacteria,3N7B1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_109326_2	582899.Hden_1770	6.97e-105	347.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,3N7HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_109326_3	1267005.KB911263_gene1310	5.852e-83	278.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2U5Q5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD1_k127_1096946_6	1120956.JHZK01000021_gene1614	1.81e-72	260.0	COG3920@1|root,COG4191@1|root,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TZIU@28211|Alphaproteobacteria,1JQNG@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK
HKD1_k127_1096946_9	1267005.KB911265_gene3620	2.752e-20	92.0	2EJPG@1|root,33DEA@2|Bacteria,1NFP3@1224|Proteobacteria,2UK0D@28211|Alphaproteobacteria,3N96N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1096946_1	1267005.KB911255_gene2525	8.858e-135	439.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,3N686@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	glycosyl transferase group 1	MA20_01620	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_1096946_2	1267005.KB911255_gene2524	9.005e-125	405.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,3N6QR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	lpxH	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD1_k127_1096946_3	582899.Hden_2286	4.244e-108	362.0	COG0834@1|root,COG0834@2|Bacteria,1MXIA@1224|Proteobacteria,2VETI@28211|Alphaproteobacteria,3N6XA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	MA20_22110	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_1096946_7	717785.HYPMC_0781	1.699e-35	154.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,3N6CF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
HKD1_k127_1096946_4	1267005.KB911255_gene2522	1.567e-101	341.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,3N6CF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
HKD1_k127_1096946_5	314231.FP2506_04556	2.75e-99	336.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2PKR8@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	DNA polymerase Ligase (LigD)	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_1096946_0	107636.JQNK01000009_gene1230	2.007e-162	534.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria,2UPWW@28211|Alphaproteobacteria,371HB@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_1096946_8	670292.JH26_01265	1.716e-21	100.0	COG0784@1|root,COG0784@2|Bacteria,1N9Y6@1224|Proteobacteria,2TW7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_1103168_5	670307.HYPDE_22728	6.257e-183	591.0	COG4477@1|root,COG4477@2|Bacteria,1QVDU@1224|Proteobacteria,2TWCR@28211|Alphaproteobacteria,3N9ID@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
HKD1_k127_1103168_2	582899.Hden_0037	4.738e-207	650.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,3N6BB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_1103168_23	717785.HYPMC_0046	1.237e-12	73.0	COG5567@1|root,COG5567@2|Bacteria	2|Bacteria	N	small periplasmic lipoprotein	yifL	-	-	-	-	-	-	-	-	-	-	-	LPAM_2
HKD1_k127_1103168_0	582899.Hden_0035	2.209e-231	726.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,3N69U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_1103168_15	670307.HYPDE_22708	4.141e-67	234.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,3N71V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Thioredoxin-like	tlpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_1103168_10	1267005.KB911257_gene1067	1.331e-144	463.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,3N65B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HKD1_k127_1103168_14	670307.HYPDE_22688	1.106e-68	241.0	29525@1|root,2ZSEY@2|Bacteria,1RF0P@1224|Proteobacteria,2U90Q@28211|Alphaproteobacteria,3N8GN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103168_6	717785.HYPMC_0040	5.601e-169	539.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,3N6CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1103168_18	717785.HYPMC_0368	9.226e-42	157.0	COG0664@1|root,COG0664@2|Bacteria,1N6WV@1224|Proteobacteria,2U63Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_1103168_13	670307.HYPDE_37028	2.288e-75	259.0	COG3495@1|root,COG3495@2|Bacteria,1RB8H@1224|Proteobacteria,2UFFR@28211|Alphaproteobacteria,3N8JU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
HKD1_k127_1103168_1	717785.HYPMC_0711	1.389e-209	662.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2TTEF@28211|Alphaproteobacteria,3N77U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_1103168_12	648757.Rvan_0577	8.098e-90	305.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria,3N811@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	bceA	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1103168_17	648757.Rvan_0576	5.858e-48	188.0	COG4531@1|root,COG4531@2|Bacteria,1N099@1224|Proteobacteria,2UHIQ@28211|Alphaproteobacteria,3N8RF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Protein of unknown function (DUF2796)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2796
HKD1_k127_1103168_21	717785.HYPMC_3713	4.174e-20	92.0	2CMAN@1|root,32SE6@2|Bacteria,1RIK0@1224|Proteobacteria,2U9U4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_15930	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103168_24	1245469.S58_61280	3.237e-08	57.0	2CMAN@1|root,32SE6@2|Bacteria,1RIK0@1224|Proteobacteria,2U9U4@28211|Alphaproteobacteria,3JZGB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_15930	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103168_8	582899.Hden_0026	9.858e-163	518.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria,3N6C9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	2-deoxycytidine 5-triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
HKD1_k127_1103168_3	1267005.KB911257_gene1061	4.472e-206	648.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3N64T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_1103168_16	1267005.KB911257_gene1060	5.897e-62	215.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HKD1_k127_1103168_7	1267005.KB911257_gene1059	1.528e-164	526.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,3N7NX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_1103168_19	1125973.JNLC01000014_gene2567	4.897e-33	146.0	COG3474@1|root,COG3474@2|Bacteria,1RCV0@1224|Proteobacteria,2U6HG@28211|Alphaproteobacteria,3JZ16@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1103168_11	648757.Rvan_2373	1.41e-96	325.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria,3N6GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD1_k127_1103168_9	1267005.KB911257_gene725	2.715e-158	507.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,3N63W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_1103168_4	1267005.KB911257_gene726	1.823e-183	582.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,3N6G5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	acetylornithine	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1111891_3	582899.Hden_3265	7.223e-15	80.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,3N78N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Smr domain	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD1_k127_1111891_0	1267005.KB911257_gene1000	9.291e-126	417.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria,3N88Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	MltA specific insert domain	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HKD1_k127_1111891_1	582899.Hden_3267	2.694e-80	275.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,3N6W9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	import inner membrane translocase subunit Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD1_k127_1111891_2	765911.Thivi_1094	7.544e-21	97.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1WYH1@135613|Chromatiales	135613|Chromatiales	S	PFAM FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
HKD1_k127_1137863_4	172088.AUGA01000133_gene7543	1.312e-23	104.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2TREX@28211|Alphaproteobacteria,3JSKS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_1137863_1	1267005.KB911255_gene2889	3.403e-105	347.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,3N6V1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD1_k127_1137863_0	1267005.KB911255_gene2888	3.348e-270	833.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,3N6AF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_1137863_3	1267005.KB911255_gene2887	9.061e-60	212.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,3N6VQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD1_k127_1137863_2	582899.Hden_0839	2.938e-62	222.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,3N6YB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD1_k127_1137863_5	1267005.KB911255_gene2885	2.985e-14	72.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,3N6VS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	MA20_29175	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
HKD1_k127_1168503_8	107636.JQNK01000009_gene2503	2.775e-44	161.0	COG3193@1|root,COG3193@2|Bacteria,1N1CR@1224|Proteobacteria,2VG7V@28211|Alphaproteobacteria,36Y8T@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD1_k127_1168503_12	1267005.KB911259_gene3849	9.461e-16	80.0	2EPBC@1|root,33GY4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1168503_7	384765.SIAM614_08683	5.387e-48	178.0	COG3247@1|root,COG3247@2|Bacteria,1R63F@1224|Proteobacteria,2U3AR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_1168503_9	670307.HYPDE_35838	8.659e-44	168.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,3N7CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Thiamine monophosphate synthase	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_1168503_5	582899.Hden_2450	5.768e-110	366.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N70G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD1_k127_1168503_4	1267005.KB911259_gene3900	4.093e-122	397.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,3N6I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_1168503_2	670307.HYPDE_35853	2.949e-161	515.0	COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria,3N6Q5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	MotA TolQ ExbB proton channel family	MA20_18055	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HKD1_k127_1168503_1	1267005.KB911256_gene1946	7.875e-168	532.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,3N6EY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	OmpA family	MA20_18060	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
HKD1_k127_1168503_0	1267005.KB911260_gene3446	3.007e-239	754.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N6E7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	lipid A ABC exporter family, fused ATPase and inner membrane subunits	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1168503_10	1267005.KB911260_gene3447	2.06e-37	144.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,3N7B4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_1168503_6	670307.HYPDE_35873	2.13e-55	201.0	COG5317@1|root,COG5317@2|Bacteria,1RJIA@1224|Proteobacteria,2U9ID@28211|Alphaproteobacteria,3N766@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1465)	MA20_18080	-	-	ko:K13592	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF1465
HKD1_k127_1168503_11	1267005.KB911260_gene3450	7.312e-16	79.0	COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
HKD1_k127_1168503_3	1267005.KB911260_gene3451	5.724e-148	477.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,3N6K9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADPH quinone oxidoreductase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1168503_13	1267005.KB911255_gene3031	1.663e-05	51.0	28W98@1|root,2ZI9R@2|Bacteria,1NQ3G@1224|Proteobacteria,2TT2E@28211|Alphaproteobacteria,3N8E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1172830_7	717785.HYPMC_1299	7.343e-32	130.0	COG5496@1|root,COG5496@2|Bacteria,1RIY6@1224|Proteobacteria,2U68P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_1172830_4	1267005.KB911260_gene3485	2.16e-105	355.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TUBN@28211|Alphaproteobacteria,3N8IA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	MA20_25165	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_1172830_3	1267005.KB911260_gene3484	5.579e-108	362.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,3N7RQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	MA20_46305	-	-	-	-	-	-	-	-	-	-	-	DUF1134
HKD1_k127_1172830_6	1267005.KB911260_gene3483	6.234e-43	167.0	COG1376@1|root,COG1376@2|Bacteria,1MUAB@1224|Proteobacteria,2TTXM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_1172830_1	1267005.KB911260_gene3480	8.419e-194	621.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria,3N8A7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1172830_2	1267005.KB911260_gene3478	5.72e-181	581.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,3N6K6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
HKD1_k127_1172830_5	1267005.KB911260_gene3477	9.71e-59	207.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,3N6Y4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnB	GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_1172830_0	1267005.KB911260_gene3476	2.075e-269	833.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,3N6E8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_1262371_0	582899.Hden_2667	8.623e-212	674.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3N6QE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_1262371_3	717785.HYPMC_0729	2.735e-117	385.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2TR7B@28211|Alphaproteobacteria,3N7VM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_1262371_7	159087.Daro_3862	1.364e-06	57.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VVVB@28216|Betaproteobacteria,2KX6R@206389|Rhodocyclales	206389|Rhodocyclales	H	COG2104 Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_1262371_2	717785.HYPMC_0733	4.133e-119	392.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,3N7I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HKD1_k127_1262371_5	1267005.KB911263_gene1343	1.757e-80	278.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2TSXT@28211|Alphaproteobacteria,3N8J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_1262371_6	717785.HYPMC_0735	2.266e-56	209.0	COG5607@1|root,COG5607@2|Bacteria,1RH6R@1224|Proteobacteria,2U7IN@28211|Alphaproteobacteria,3N7G4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD1_k127_1262371_1	1267005.KB911263_gene1335	4.034e-179	567.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,3N6K3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD1_k127_1313630_4	1267005.KB911258_gene443	3.214e-06	49.0	COG3203@1|root,COG3203@2|Bacteria,1R626@1224|Proteobacteria,2VGUQ@28211|Alphaproteobacteria,3N9I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HKD1_k127_1313630_1	670307.HYPDE_30083	2.399e-202	645.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,3N7IV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HKD1_k127_1313630_0	582899.Hden_1641	1.266e-245	781.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2TQU8@28211|Alphaproteobacteria,3N64G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	opgH	GO:0005575,GO:0016020	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3
HKD1_k127_1313630_3	582899.Hden_1642	4.235e-103	349.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria,3N6UG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF697)	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
HKD1_k127_1313630_2	1267005.KB911258_gene447	6.909e-175	557.0	COG3106@1|root,COG3106@2|Bacteria,1MX6E@1224|Proteobacteria,2TR9Y@28211|Alphaproteobacteria,3N6JM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YcjX-like family, DUF463	MA20_04550	-	-	ko:K06918	-	-	-	-	ko00000	-	-	-	DUF463
HKD1_k127_1347816_1	1267005.KB911258_gene476	2.825e-33	129.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,3N7AQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	BolA-like protein	bolA2	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD1_k127_1347816_0	1267005.KB911258_gene490	0.0	1005.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,3N61N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_1367112_0	1267005.KB911261_gene2259	0.0	1334.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,3N6C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_1367112_6	1267005.KB911261_gene2260	1.696e-47	172.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,3N72J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD1_k127_1367112_3	717785.HYPMC_2585	9.459e-70	244.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,3N6WR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_1367112_1	1267005.KB911261_gene2262	4.119e-122	396.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,3N66T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_1367112_4	1429916.X566_23115	3.221e-65	226.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,3JV49@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_1367112_2	582899.Hden_1005	1.741e-92	313.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,3N6IV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD1_k127_1367112_7	1267005.KB911261_gene2265	3.85e-23	102.0	COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,3N7FM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD1_k127_1367112_5	582899.Hden_1003	3.141e-49	178.0	COG0393@1|root,COG0393@2|Bacteria,1N2F5@1224|Proteobacteria,2UDZU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD1_k127_139807_4	1267005.KB911260_gene3453	2.515e-65	235.0	COG2200@1|root,COG2200@2|Bacteria,1MU4F@1224|Proteobacteria,2TU9M@28211|Alphaproteobacteria,3N7EJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	MA20_05620	-	-	ko:K13593	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	EAL
HKD1_k127_139807_2	1267005.KB911260_gene3452	6.907e-101	336.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,3N6SE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Haloacid dehalogenase-like hydrolase	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD1_k127_139807_0	717785.HYPMC_2989	0.0	1015.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,3N6B3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_139807_1	441620.Mpop_1756	6.751e-140	451.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,1JRED@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_139807_5	1267005.KB911257_gene1136	3.946e-58	216.0	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U1ZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Extensin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
HKD1_k127_139807_3	670307.HYPDE_28443	1.32e-89	299.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,3N6XZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_139807_6	1116369.KB890024_gene1497	3.142e-16	79.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,43KXX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_140256_6	717785.HYPMC_4424	1.874e-61	217.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_140256_4	1267005.KB911257_gene701	4.116e-107	353.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria,3N872@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_140256_3	1267005.KB911257_gene700	1.071e-121	399.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria,3N6QK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_140256_0	1267005.KB911257_gene699	1.785e-168	534.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,3N6KI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD1_k127_140256_2	1267005.KB911257_gene698	4.581e-127	413.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,3N6FQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_140256_5	670307.HYPDE_39028	1.014e-75	258.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,3N6C8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD1_k127_1413993_0	648757.Rvan_2148	0.0	1358.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,3N8XE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
HKD1_k127_1448925_10	582899.Hden_0840	1.839e-12	74.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,3N6VS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	MA20_29175	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
HKD1_k127_1448925_2	582899.Hden_0841	2.75e-192	611.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,3N85Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M48 Ste24p	MA20_29180	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19
HKD1_k127_1448925_4	1267005.KB911255_gene2883	9.565e-143	463.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TS06@28211|Alphaproteobacteria,3N640@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	aspB	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_1448925_9	582899.Hden_2565	2.033e-25	114.0	2EAB6@1|root,334FE@2|Bacteria,1R4B5@1224|Proteobacteria,2UGZI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	LTXXQ motif family protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
HKD1_k127_1448925_1	1532558.JL39_11810	2.898e-214	697.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,4B8HZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_1448925_5	1267005.KB911255_gene2880	6.57e-130	429.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD1_k127_1448925_0	670307.HYPDE_27708	0.0	1304.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,3N6HJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HKD1_k127_1448925_3	460265.Mnod_6050	6.559e-171	544.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,1JS8F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_1448925_7	666685.R2APBS1_1728	6.029e-28	115.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XB32@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1448925_8	622637.KE124774_gene1061	8.366e-26	111.0	COG0526@1|root,COG0526@2|Bacteria,1MZQJ@1224|Proteobacteria,2UBRX@28211|Alphaproteobacteria,370HE@31993|Methylocystaceae	28211|Alphaproteobacteria	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
HKD1_k127_1448925_6	663610.JQKO01000001_gene625	1.017e-42	158.0	COG0590@1|root,COG0590@2|Bacteria,1PGKD@1224|Proteobacteria,2U0F8@28211|Alphaproteobacteria,3NBNQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
HKD1_k127_146666_10	402881.Plav_3096	1.735e-33	130.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,1JP5M@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Hemimethylated DNA-binding protein YccV like	hspQ	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
HKD1_k127_146666_0	717785.HYPMC_1941	5.735e-208	652.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,3N866@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the HpcH HpaI aldolase family	mcl1	GO:0003674,GO:0003824,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872,GO:0047777,GO:0050083	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_146666_8	717785.HYPMC_4628	1.408e-35	139.0	COG1846@1|root,COG1846@2|Bacteria,1RJRY@1224|Proteobacteria,2UA4D@28211|Alphaproteobacteria,3N8VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_146666_4	1185652.USDA257_c20610	2.158e-95	317.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,4BAQU@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_146666_2	717785.HYPMC_4457	5.383e-141	462.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N7KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_146666_7	663610.JQKO01000008_gene207	4.515e-37	145.0	2FD7F@1|root,3459F@2|Bacteria,1NZVP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_146666_9	234267.Acid_0292	7.661e-35	150.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_0292|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_146666_5	1101190.ARWB01000001_gene1516	1.745e-63	230.0	COG4977@1|root,COG4977@2|Bacteria,1QW07@1224|Proteobacteria,2TYJG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AraC-binding-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HKD1_k127_146666_1	1267005.KB911261_gene2209	1.551e-141	455.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,3N83R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_146666_3	1267005.KB911261_gene2208	8.656e-131	429.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TT9M@28211|Alphaproteobacteria,3N6SF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_146666_12	1267005.KB911261_gene2205	1.535e-21	102.0	2991I@1|root,2ZW53@2|Bacteria,1P4XN@1224|Proteobacteria,2UZ03@28211|Alphaproteobacteria,3N94R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_146666_6	648757.Rvan_1366	9.07e-60	215.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	pcs	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_146666_11	1237149.C900_05756	1.468e-22	102.0	COG0702@1|root,COG0702@2|Bacteria,4NG89@976|Bacteroidetes,47PTQ@768503|Cytophagia	976|Bacteroidetes	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD1_k127_148763_4	1122132.AQYH01000005_gene705	4.03e-32	126.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,4BG42@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional	nolR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22042	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_148763_2	1304877.KI519400_gene1638	2.045e-148	473.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,3JQYX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_148763_1	582899.Hden_3184	1.1e-171	548.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,3N66D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD1_k127_148763_3	670307.HYPDE_39098	1.174e-85	293.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,3N6TE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	peptidyl-prolyl isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
HKD1_k127_148763_0	670307.HYPDE_39093	1.877e-219	697.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,3N65A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_1506550_4	1267005.KB911256_gene1811	2.17e-109	357.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,3N6A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_1506550_11	1211115.ALIQ01000057_gene2769	3.661e-29	120.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,3NBJV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4170)	MA20_05805	-	-	-	-	-	-	-	-	-	-	-	DUF4170
HKD1_k127_1506550_0	717785.HYPMC_3823	4.051e-240	758.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N80Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA	-	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1506550_9	224308.BSU26890	5.099e-44	171.0	COG3409@1|root,COG3409@2|Bacteria,1VCJN@1239|Firmicutes,4HTZB@91061|Bacilli	91061|Bacilli	M	Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan	csn	GO:0003674,GO:0003824,GO:0004553,GO:0016787,GO:0016798,GO:0016977	3.2.1.132	ko:K01233	ko00520,ko01100,map00520,map01100	-	R02833	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_46
HKD1_k127_1506550_7	582899.Hden_2586	1.499e-86	298.0	COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,2U7HD@28211|Alphaproteobacteria,3N8EQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Protein tyrosine serine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF442,Y_phosphatase3
HKD1_k127_1506550_1	717785.HYPMC_3826	1.237e-230	733.0	COG1519@1|root,COG2121@1|root,COG1519@2|Bacteria,COG2121@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,3N83H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Domain of unknown function (DUF374)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HKD1_k127_1506550_6	1267005.KB911263_gene1349	5.589e-100	336.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,3N7NY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD1_k127_1506550_10	717785.HYPMC_3828	4.831e-31	124.0	COG3908@1|root,COG3908@2|Bacteria,1N7PA@1224|Proteobacteria,2UFTN@28211|Alphaproteobacteria,3N7FG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2093)	MA20_05765	-	-	-	-	-	-	-	-	-	-	-	DUF2093
HKD1_k127_1506550_3	582899.Hden_2590	9.89e-205	648.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,3N6IY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD1_k127_1506550_2	1267005.KB911263_gene1346	4.813e-205	646.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,3N6I7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_1506550_5	717785.HYPMC_3831	1.253e-102	344.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_1506550_8	717785.HYPMC_3832	1.706e-63	222.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,3N6Y6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.3,3.5.4.33	ko:K01485,ko:K01487,ko:K11991	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922,R10223	RC00074,RC00204,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
HKD1_k127_1520187_2	1267005.KB911255_gene2867	1.551e-19	91.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,3N6P0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD1_k127_1520187_0	1267005.KB911255_gene2866	1.279e-143	466.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,3N64E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD1_k127_1520187_1	1267005.KB911255_gene2865	1.595e-98	330.0	COG0791@1|root,COG0791@2|Bacteria,1RBV6@1224|Proteobacteria,2TVPH@28211|Alphaproteobacteria,3N8JZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD1_k127_1578351_12	670307.HYPDE_33563	4.2e-34	135.0	COG4731@1|root,COG4731@2|Bacteria,1NHGE@1224|Proteobacteria,2UM5U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_1578351_0	1267005.KB911257_gene910	0.0	1171.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3N61V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_1578351_11	1231190.NA8A_13450	1.693e-38	148.0	2DPP7@1|root,332UY@2|Bacteria,1N75H@1224|Proteobacteria,2UFXZ@28211|Alphaproteobacteria,43KVV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
HKD1_k127_1578351_7	1267005.KB911257_gene902	7.722e-91	304.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,2TV6N@28211|Alphaproteobacteria,3N714@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Ribosomal protein L11 methyltransferase (PrmA)	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736	-	-	-	-	-	-	-	-	-	-	PrmA
HKD1_k127_1578351_9	670307.HYPDE_41348	1.482e-62	219.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,3N6XR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	EVE domain	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD1_k127_1578351_13	717785.HYPMC_4811	8.461e-21	99.0	COG2246@1|root,COG2246@2|Bacteria,1N1WS@1224|Proteobacteria	1224|Proteobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD1_k127_1578351_1	717785.HYPMC_4812	1.014e-259	809.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,2TU7I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_1578351_8	717785.HYPMC_4813	1.844e-70	261.0	COG1287@1|root,COG1287@2|Bacteria,1RCIB@1224|Proteobacteria,2U677@28211|Alphaproteobacteria,3N8PP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1578351_4	1267005.KB911257_gene904	1.39e-141	456.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,3N6NQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_1578351_3	582899.Hden_3451	3.671e-148	477.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,3N66A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_1578351_5	670307.HYPDE_41333	2.522e-111	368.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,3N6I6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_1578351_10	1267005.KB911257_gene907	1.492e-41	162.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,3N77E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD1_k127_1578351_6	1267005.KB911257_gene908	6.299e-109	372.0	COG4223@1|root,COG4223@2|Bacteria,1N3EE@1224|Proteobacteria,2VAHJ@28211|Alphaproteobacteria,3N97M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1578351_2	582899.Hden_3447	4.434e-190	617.0	COG3898@1|root,COG3898@2|Bacteria,1P5RR@1224|Proteobacteria,2TT5Q@28211|Alphaproteobacteria,3N6D4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	HemY protein N-terminus	lapB	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_19
HKD1_k127_1603317_2	717785.HYPMC_4420	1.148e-88	297.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD1_k127_1603317_4	1126627.BAWE01000005_gene5583	1.623e-68	239.0	COG3300@1|root,COG5001@1|root,COG3300@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JT1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Bacterial signalling protein N terminal repeat	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS_4,PAS_7,dCache_1
HKD1_k127_1603317_1	1411123.JQNH01000001_gene838	2.576e-90	312.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_4,PAS_7
HKD1_k127_1603317_0	582899.Hden_2088	1.998e-132	446.0	COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,2TW2E@28211|Alphaproteobacteria,3N8SH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_1603317_3	1267005.KB911261_gene2247	2.755e-84	293.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_161260_16	1090318.ATTI01000001_gene2050	1.274e-05	55.0	COG3685@1|root,COG3685@2|Bacteria,1REKN@1224|Proteobacteria,2U73U@28211|Alphaproteobacteria,2K47D@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
HKD1_k127_161260_2	460265.Mnod_1367	1.851e-178	578.0	COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,1NW4Z@1224|Proteobacteria,2U14Z@28211|Alphaproteobacteria,1JWZZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KT	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_161260_6	1333998.M2A_1213	2.17e-90	311.0	COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,2TVH6@28211|Alphaproteobacteria,4BRRE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Ion channel	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2,cNMP_binding
HKD1_k127_161260_8	1238182.C882_0310	2.588e-53	196.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2U1G1@28211|Alphaproteobacteria,2JSUA@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_161260_13	1267005.KB911258_gene491	8.8e-10	67.0	2FC0Q@1|root,3444U@2|Bacteria,1P1FG@1224|Proteobacteria,2UURN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_161260_11	107635.AZUO01000001_gene1901	1.834e-13	76.0	2FC0Q@1|root,3444U@2|Bacteria,1P1FG@1224|Proteobacteria,2UURN@28211|Alphaproteobacteria,370MA@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_161260_7	118168.MC7420_4451	6.232e-62	245.0	COG2199@1|root,COG2202@1|root,COG3829@1|root,COG3850@1|root,COG4191@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1GHCI@1117|Cyanobacteria,1HHXQ@1150|Oscillatoriales	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD1_k127_161260_5	1173027.Mic7113_0174	3.819e-93	346.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1G17N@1117|Cyanobacteria,1H8WZ@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cya2	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD1_k127_161260_14	595536.ADVE02000001_gene53	5.596e-07	56.0	2FC0Q@1|root,3444U@2|Bacteria,1P1FG@1224|Proteobacteria,2UURN@28211|Alphaproteobacteria,370MA@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_161260_15	598659.NAMH_1184	6.857e-07	53.0	2AY0S@1|root,31Q2B@2|Bacteria,1QMQY@1224|Proteobacteria,42SY0@68525|delta/epsilon subdivisions,2YPGA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacteriophage replication gene A protein (GPA)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPA
HKD1_k127_161260_9	648757.Rvan_2633	2.716e-39	149.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,2UCCY@28211|Alphaproteobacteria,3N8ZD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD1_k127_161260_4	648757.Rvan_2632	7.896e-103	340.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria,3N81M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	MA20_30090	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_161260_3	1267005.KB911260_gene3377	2.409e-154	502.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2TV39@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_161260_0	1267005.KB911255_gene2661	9.466e-282	889.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TUBY@28211|Alphaproteobacteria,3N6C2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
HKD1_k127_161260_1	1267005.KB911265_gene3637	8.241e-198	633.0	2C0EB@1|root,32R6V@2|Bacteria,1NTFI@1224|Proteobacteria,2UPQF@28211|Alphaproteobacteria,3N82A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_161260_12	717785.HYPMC_4200	3.387e-10	64.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD1_k127_1618706_0	395964.KE386496_gene513	2.378e-225	711.0	COG4986@1|root,COG4986@2|Bacteria,1MV85@1224|Proteobacteria,2TTRP@28211|Alphaproteobacteria,3NAPQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_1618706_1	1380394.JADL01000018_gene1921	1.602e-167	530.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria,2JYNK@204441|Rhodospirillales	204441|Rhodospirillales	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD1_k127_1618706_2	1380394.JADL01000018_gene1922	1.081e-152	488.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1618706_8	438753.AZC_2247	2.16e-11	67.0	COG2906@1|root,COG2906@2|Bacteria,1RIF5@1224|Proteobacteria,2UC4X@28211|Alphaproteobacteria,3F00R@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	BFD-like [2Fe-2S] binding domain	MA20_01365	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD1_k127_1618706_3	1267005.KB911256_gene1522	8.46e-141	471.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein conserved in bacteria	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	DUF900,Sel1
HKD1_k127_1618706_6	118166.JH976537_gene3002	9.504e-28	130.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_1618706_9	1380394.JADL01000001_gene3093	1.734e-10	68.0	2DJAT@1|root,305AP@2|Bacteria,1PXB1@1224|Proteobacteria,2U35F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HKD1_k127_1618706_5	1197906.CAJQ02000010_gene3376	5.626e-83	280.0	COG2610@1|root,COG2610@2|Bacteria,1N2VU@1224|Proteobacteria,2TV53@28211|Alphaproteobacteria,3JQPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	GntP family permease	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
HKD1_k127_1618706_4	1197906.CAJQ02000010_gene3376	1.056e-121	413.0	COG2610@1|root,COG2610@2|Bacteria,1N2VU@1224|Proteobacteria,2TV53@28211|Alphaproteobacteria,3JQPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	GntP family permease	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
HKD1_k127_1618706_7	582899.Hden_1602	1.268e-16	79.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2U93B@28211|Alphaproteobacteria,3N8I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_1626330_0	717785.HYPMC_2663	0.0	1124.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,3N626@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_1626330_3	670307.HYPDE_29463	1.129e-56	203.0	COG2913@1|root,COG2913@2|Bacteria,1Q3I4@1224|Proteobacteria,2VABI@28211|Alphaproteobacteria,3N7DX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	SmpA / OmlA family	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HKD1_k127_1626330_7	391937.NA2_03327	5.322e-35	141.0	COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,43JVS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Ubiquinol-cytochrome C chaperone	-	-	-	ko:K17662	-	-	-	-	ko00000,ko03029	-	-	-	Ubiq_cyt_C_chap
HKD1_k127_1626330_5	1267005.KB911256_gene1541	2.273e-43	166.0	COG1399@1|root,COG1399@2|Bacteria,1Q3HX@1224|Proteobacteria,2VABC@28211|Alphaproteobacteria,3N7EK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	-	-	-	-	-	-	-	-	-	DUF177
HKD1_k127_1626330_2	1267005.KB911256_gene1542	1.629e-173	550.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,3N6GW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD1_k127_1626330_1	582899.Hden_1292	2.087e-177	559.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,3N6J7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_1626330_4	1267005.KB911256_gene1544	1.427e-50	181.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,3N75G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_1626330_6	1267005.KB911256_gene1545	1.518e-42	159.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria,3N74B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	MerR family regulatory protein	merR	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_171173_5	1267005.KB911255_gene2700	1.989e-92	309.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,3N662@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_171173_9	717785.HYPMC_4622	4.14e-58	207.0	2DXVU@1|root,32V47@2|Bacteria,1N4I2@1224|Proteobacteria,2VCSA@28211|Alphaproteobacteria,3N7EW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD1_k127_171173_10	288000.BBta_3389	3.015e-34	138.0	COG0526@1|root,COG0526@2|Bacteria,1MZQJ@1224|Proteobacteria,2UBRX@28211|Alphaproteobacteria,3JZVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
HKD1_k127_171173_6	693986.MOC_4678	7.75e-90	310.0	COG0785@1|root,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TUNG@28211|Alphaproteobacteria,1JQRY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM cytochrome c biogenesis protein transmembrane region	ccdA	-	-	-	-	-	-	-	-	-	-	-	DsbD
HKD1_k127_171173_3	1246459.KB898359_gene2378	2.068e-105	348.0	COG4117@1|root,COG4117@2|Bacteria,1MX97@1224|Proteobacteria,2U0ZF@28211|Alphaproteobacteria,4BBB6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD1_k127_171173_4	1500259.JQLD01000017_gene4716	4.38e-102	338.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,4B83W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HKD1_k127_171173_7	717785.HYPMC_1306	3.999e-72	246.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD1_k127_171173_1	717785.HYPMC_3843	1.34e-196	622.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,3N80X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidase M16 inactive domain	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_171173_0	1267005.KB911256_gene1804	5.098e-208	655.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,3N80G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	MA20_05655	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_171173_8	717785.HYPMC_0524	2.46e-65	226.0	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,3N75E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
HKD1_k127_171173_11	1267005.KB911257_gene854	2.643e-30	121.0	COG5568@1|root,COG5568@2|Bacteria,1N9BT@1224|Proteobacteria,2UFNF@28211|Alphaproteobacteria,3N96H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1150)	MA20_24245	-	-	-	-	-	-	-	-	-	-	-	DUF1150
HKD1_k127_171173_2	1267005.KB911255_gene2496	3.19e-133	433.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,3N6AD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	NmrA-like family	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
HKD1_k127_181000_2	717785.HYPMC_4185	2.822e-67	230.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_181000_1	1267005.KB911255_gene2930	9.667e-155	507.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_181000_3	1117943.SFHH103_01739	2.618e-44	170.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2TV0E@28211|Alphaproteobacteria,4B9T2@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	fnrL	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
HKD1_k127_181000_0	1267005.KB911259_gene4033	8.782e-158	514.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_1888963_1	886293.Sinac_5187	1.477e-51	188.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_1888963_0	717785.HYPMC_4651	2.056e-229	715.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,3N68V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_1888963_4	1267005.KB911257_gene860	8.562e-20	90.0	2C8HF@1|root,2ZXE6@2|Bacteria,1R5PH@1224|Proteobacteria,2U64K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_43475	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_192488_3	717785.HYPMC_4099	9.879e-70	242.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	MA20_27120	-	-	ko:K07799,ko:K18990	ko02020,map02020	M00648,M00720	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_192488_0	717785.HYPMC_4098	0.0	1100.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N6DF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_27115	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_192488_4	717785.HYPMC_4098	3.27e-67	232.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N6DF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_27115	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_192488_2	1298867.AUES01000012_gene5466	1.834e-70	241.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JQMT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_27115	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_192488_1	1101190.ARWB01000001_gene3	2.695e-111	368.0	COG4313@1|root,COG4313@2|Bacteria,1ND36@1224|Proteobacteria	1224|Proteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD1_k127_192488_5	1267005.KB911258_gene401	2.272e-52	186.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD1_k127_2018426_0	864069.MicloDRAFT_00067170	1.109e-263	827.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2TREM@28211|Alphaproteobacteria,1JSA7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_2018426_1	1297569.MESS2_1560008	1.178e-155	499.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2TSIJ@28211|Alphaproteobacteria,43JAN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_2032398_1	395963.Bind_0014	1.749e-247	779.0	COG3511@1|root,COG3511@2|Bacteria,1MVNS@1224|Proteobacteria,2U1QU@28211|Alphaproteobacteria,3NBYE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HKD1_k127_2032398_4	395964.KE386496_gene1544	1.063e-111	375.0	COG1409@1|root,COG1409@2|Bacteria,1R8W7@1224|Proteobacteria,2U64B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_2032398_0	670307.HYPDE_29878	1.426e-248	789.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,3N63S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	exonuclease RecJ	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_2032398_3	1267005.KB911264_gene3153	3.386e-122	403.0	28J0S@1|root,2Z8XX@2|Bacteria,1P9IP@1224|Proteobacteria,2TSZQ@28211|Alphaproteobacteria,3N827@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2032398_2	582899.Hden_1297	1.736e-146	471.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_2047112_5	1123229.AUBC01000018_gene3682	1.648e-47	177.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2TYJM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_2047112_1	1267005.KB911256_gene1861	3.772e-123	404.0	COG3049@1|root,COG3049@2|Bacteria,1RC5C@1224|Proteobacteria,2U6YD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2047112_0	1267005.KB911256_gene2001	7.452e-141	462.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,2TVJ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Inner membrane protein involved in colicin E2 resistance	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
HKD1_k127_2047112_2	472175.EL18_00389	8.886e-118	385.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2TURT@28211|Alphaproteobacteria,43H12@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_2047112_4	426355.Mrad2831_4777	2.122e-63	224.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,2U2X2@28211|Alphaproteobacteria,1JRW5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,MarR_2
HKD1_k127_2047112_3	1267005.KB911255_gene2678	3.788e-70	245.0	29Q66@1|root,30B54@2|Bacteria,1N9YZ@1224|Proteobacteria,2TS6J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4166)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4166
HKD1_k127_2047112_6	622637.KE124774_gene2573	9.301e-11	63.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,36XJI@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_2055354_4	1267005.KB911256_gene2083	7.956e-64	222.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,3N8S2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Integral membrane protein TerC family	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD1_k127_2055354_0	717785.HYPMC_2611	6.719e-146	469.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,3N7BG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
HKD1_k127_2055354_2	582899.Hden_1385	8.272e-116	389.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,3N6NG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD1_k127_2055354_1	582899.Hden_1383	3.188e-129	422.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2TTEI@28211|Alphaproteobacteria,3N669@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_2055354_3	670307.HYPDE_31778	5.673e-103	351.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TW0Q@28211|Alphaproteobacteria,3N9IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DM	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Wzz
HKD1_k127_2055354_5	1041142.ATTP01000019_gene5148	1.128e-08	66.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1Q6J4@1224|Proteobacteria,2VCPI@28211|Alphaproteobacteria,4BDJE@82115|Rhizobiaceae	28211|Alphaproteobacteria	DM	protein tyrosine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD1_k127_2062183_8	670307.HYPDE_34168	2.511e-61	214.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,3N62U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_2062183_7	1267005.KB911256_gene1927	2.285e-67	233.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,3N733@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_2062183_3	670307.HYPDE_34178	2.053e-103	342.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria,3N6N3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	MA20_36560	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_2062183_4	582899.Hden_2249	2.059e-95	317.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,3N6S7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Uracil-DNA glycosylase	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_2062183_9	1267005.KB911256_gene1924	5.926e-60	216.0	2E4J2@1|root,32ZE4@2|Bacteria,1N7YM@1224|Proteobacteria,2UBV9@28211|Alphaproteobacteria,3N8XF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
HKD1_k127_2062183_10	582899.Hden_2250	2.487e-48	186.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2TSSW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD1_k127_2062183_5	1267005.KB911256_gene1922	1.966e-73	252.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2TSSW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Redoxin domain protein	MA20_36550	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD1_k127_2062183_6	1267005.KB911256_gene1921	6.603e-73	248.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,3N70C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_2062183_1	670307.HYPDE_34198	3.247e-143	459.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,3N69T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_2062183_0	1267005.KB911256_gene1919	5.07e-254	806.0	COG0457@1|root,COG0741@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,3N6U7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD1_k127_2062183_2	1267005.KB911256_gene1918	5.12e-116	381.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria,3N777@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD1_k127_2062183_11	1126627.BAWE01000005_gene4814	2.035e-37	143.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2U6XK@28211|Alphaproteobacteria,3JVS4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_2064387_4	582899.Hden_2109	3.639e-33	136.0	COG4731@1|root,COG4731@2|Bacteria,1NHGE@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_2064387_2	1380394.JADL01000002_gene1692	1.347e-53	193.0	COG2202@1|root,COG2202@2|Bacteria,1QV8B@1224|Proteobacteria,2TWQV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Single cache domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Cache_3-Cache_2
HKD1_k127_2064387_1	1267005.KB911257_gene928	1.435e-91	307.0	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U9V0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
HKD1_k127_2064387_5	935840.JAEQ01000023_gene4310	6.343e-15	76.0	COG5508@1|root,COG5508@2|Bacteria,1N7D3@1224|Proteobacteria,2UF8M@28211|Alphaproteobacteria,43M1D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
HKD1_k127_2064387_0	1267005.KB911257_gene925	1.144e-129	424.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,3N6IW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_2064387_3	1267005.KB911257_gene924	6.665e-36	142.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,3N6F7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD1_k127_2145015_2	1267005.KB911255_gene2983	9.358e-124	402.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,3N6FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_2145015_9	1396858.Q666_10415	2.899e-30	129.0	2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,1SAPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2145015_6	582899.Hden_2855	1.507e-59	208.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,3N6VX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_2145015_8	1333998.M2A_0328	9.511e-36	143.0	COG0262@1|root,COG0262@2|Bacteria,1RH02@1224|Proteobacteria,2UCTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0262 Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_2145015_0	717785.HYPMC_4126	1.589e-263	817.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_2145015_5	1122962.AULH01000009_gene3788	6.163e-78	266.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,36Y16@31993|Methylocystaceae	28211|Alphaproteobacteria	F	Formyl transferase	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
HKD1_k127_2145015_3	1267005.KB911261_gene2313	3.415e-121	402.0	COG0412@1|root,COG0412@2|Bacteria,1PP3Y@1224|Proteobacteria,2TS36@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DLH,Hydrolase_4,Peptidase_S9
HKD1_k127_2145015_7	1510531.JQJJ01000009_gene1035	1.416e-48	186.0	COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,2U4MR@28211|Alphaproteobacteria,3JWH1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
HKD1_k127_2145015_1	670307.HYPDE_37783	1.353e-162	517.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,3N69S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_2151793_3	1267005.KB911258_gene340	6.648e-32	127.0	COG1324@1|root,COG1324@2|Bacteria,1PU74@1224|Proteobacteria,2VCHK@28211|Alphaproteobacteria,3N8WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD1_k127_2151793_0	670307.HYPDE_32238	1.432e-126	411.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,3N6JV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_2151793_5	1122963.AUHB01000010_gene1677	1.713e-14	85.0	COG0741@1|root,COG0741@2|Bacteria,1MUMA@1224|Proteobacteria,2TSA5@28211|Alphaproteobacteria,36YPU@31993|Methylocystaceae	28211|Alphaproteobacteria	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD1_k127_2151793_1	582899.Hden_1087	2.208e-73	257.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,3N6WC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	MA20_31560	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_2151793_2	1267005.KB911258_gene337	6.938e-62	226.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,3N7CG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_2152162_4	1123508.JH636450_gene7191	2.183e-07	61.0	COG1028@1|root,COG1028@2|Bacteria,2IYM6@203682|Planctomycetes	203682|Planctomycetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2152162_0	1123073.KB899241_gene2662	7.305e-65	226.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1X3N7@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2152162_3	1207063.P24_18486	4.516e-16	89.0	COG0412@1|root,COG0412@2|Bacteria,1R3DI@1224|Proteobacteria,2TVEH@28211|Alphaproteobacteria,2JRNN@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD1_k127_2152162_1	1268635.Loa_00117	4.854e-52	199.0	COG1231@1|root,COG1231@2|Bacteria,1MUPQ@1224|Proteobacteria,1RZXR@1236|Gammaproteobacteria,1JDUR@118969|Legionellales	118969|Legionellales	E	amine oxidase	pao	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_2156658_0	402881.Plav_2432	2.067e-302	942.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,1JN02@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
HKD1_k127_2156658_12	1267005.KB911256_gene1769	6.618e-112	371.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,3N6SW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD1_k127_2156658_7	670307.HYPDE_23783	3.197e-154	494.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,3N6PE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HKD1_k127_2156658_3	1267005.KB911256_gene1767	2.784e-188	604.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,3N67F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_2156658_10	1267005.KB911256_gene1766	1.262e-126	422.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,3N6P4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD1_k127_2156658_13	1267005.KB911256_gene1765	2.05e-50	194.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,3N790@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_2156658_9	717785.HYPMC_0339	7.414e-152	491.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,3N6C3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_2156658_5	670307.HYPDE_23758	2.746e-166	527.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,3N6EQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD1_k127_2156658_1	1267005.KB911256_gene1762	7.383e-236	740.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,3N64U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_2156658_8	717785.HYPMC_0336	4.872e-152	488.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,3N6CM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_2156658_6	1267005.KB911256_gene1760	1.347e-155	516.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,3N6BH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_2156658_4	224914.BMEI0577	2.196e-172	553.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,1J1KW@118882|Brucellaceae	28211|Alphaproteobacteria	F	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_2156658_2	717785.HYPMC_0333	4.808e-189	595.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,3N66M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD1_k127_2156658_11	1267005.KB911256_gene1757	2.329e-125	409.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,3N638@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_215750_4	1267005.KB911260_gene3423	5.765e-72	244.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,3N679@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_215750_2	670307.HYPDE_26118	2.603e-181	583.0	COG1752@1|root,COG1752@2|Bacteria,1PI8V@1224|Proteobacteria,2VD78@28211|Alphaproteobacteria,3N96B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_215750_5	1267005.KB911256_gene1678	3.114e-68	244.0	COG0457@1|root,COG0457@2|Bacteria	1267005.KB911256_gene1678|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_215750_8	717785.HYPMC_0874	4.549e-21	101.0	2FCZI@1|root,34525@2|Bacteria,1Q4YH@1224|Proteobacteria,2VBD1@28211|Alphaproteobacteria,3N921@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_215750_7	765420.OSCT_2070	4.168e-39	153.0	COG1051@1|root,COG2110@1|root,COG1051@2|Bacteria,COG2110@2|Bacteria,2G7ID@200795|Chloroflexi,377AT@32061|Chloroflexia	32061|Chloroflexia	F	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_215750_3	1267005.KB911260_gene3422	6.076e-107	357.0	COG0790@1|root,COG0790@2|Bacteria,1MUGD@1224|Proteobacteria,2TRV0@28211|Alphaproteobacteria,3N78Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PFAM Sel1 domain protein repeat-containing protein	exoR	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD1_k127_215750_1	582899.Hden_1253	0.0	1017.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,3N6G7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_215750_0	670307.HYPDE_29273	0.0	1523.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,3N6HB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_215750_9	1267005.KB911260_gene3417	1.888e-05	56.0	COG3827@1|root,COG3827@2|Bacteria	2|Bacteria	-	-	fimV	-	-	ko:K08086,ko:K09991	-	-	-	-	ko00000	-	-	-	DUF2497
HKD1_k127_215750_6	1267005.KB911260_gene3415	1.719e-61	217.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,3N6T6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_2161052_18	1267005.KB911256_gene1991	2.206e-22	97.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,3N7MZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	MA20_03725	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD1_k127_2161052_3	1267005.KB911263_gene1364	6.994e-177	570.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
HKD1_k127_2161052_13	1267005.KB911255_gene2665	2.467e-48	185.0	COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria,3N9CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_2161052_15	1267005.KB911256_gene1849	5.615e-39	157.0	COG4731@1|root,COG4731@2|Bacteria,1NHGE@1224|Proteobacteria,2UM5U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_2161052_6	460265.Mnod_0315	9.172e-138	458.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,1JSZK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CT	adenylyl cyclase class-3 4 guanylyl cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
HKD1_k127_2161052_4	1267005.KB911256_gene1993	2.292e-162	518.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,3N6CJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	aapM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
HKD1_k127_2161052_8	1267005.KB911256_gene1994	3.764e-132	432.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2TR7G@28211|Alphaproteobacteria,3N6JI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
HKD1_k127_2161052_5	1267005.KB911256_gene1995	1.274e-150	482.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,3N64W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
HKD1_k127_2161052_9	1267005.KB911256_gene1996	7.505e-113	372.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3N64Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ABC transporter	glnQ	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
HKD1_k127_2161052_12	717785.HYPMC_1086	1.123e-51	189.0	COG0454@1|root,COG0456@2|Bacteria,1NARR@1224|Proteobacteria,2UJ98@28211|Alphaproteobacteria,3N7DP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
HKD1_k127_2161052_10	670307.HYPDE_35408	2.824e-81	275.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,3N740@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD1_k127_2161052_16	582899.Hden_2369	9.67e-37	149.0	COG5425@1|root,COG5425@2|Bacteria,1N08I@1224|Proteobacteria,2UBVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Usg family protein	MA20_32470	-	-	-	-	-	-	-	-	-	-	-	Usg
HKD1_k127_2161052_11	670307.HYPDE_35458	9.165e-61	215.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_44640	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
HKD1_k127_2161052_2	670307.HYPDE_35463	9.88e-179	564.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_2161052_7	1267005.KB911263_gene1377	2.64e-135	437.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,3N7PV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF58	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_2161052_0	670307.HYPDE_35473	0.0	1210.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria,3N7SW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4159)	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
HKD1_k127_2161052_1	1267005.KB911263_gene1379	0.0	1052.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,3N89S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane	MA20_44660	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HKD1_k127_2161052_17	1197906.CAJQ02000023_gene2466	7.499e-28	118.0	2ENBK@1|root,33FZ7@2|Bacteria,1N3KU@1224|Proteobacteria,2UE58@28211|Alphaproteobacteria,3K5UU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2161052_14	582899.Hden_2383	3.078e-43	164.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2TS0S@28211|Alphaproteobacteria,3N7Z1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD1_k127_2176788_7	1122929.KB908215_gene1124	1.457e-19	90.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	ttdR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_2176788_6	1121861.KB899910_gene755	1.029e-33	135.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,2JUCT@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c2	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD1_k127_2176788_2	1336235.JAEG01000007_gene1439	3.152e-106	350.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,4BGGH@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
HKD1_k127_2176788_1	1267005.KB911255_gene2625	1.803e-181	586.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,3N7WM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_17,Fer4_8,LUD_dom
HKD1_k127_2176788_5	1120983.KB894571_gene2403	1.4e-42	169.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,1JNWG@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HKD1_k127_2176788_0	1267005.KB911256_gene1817	7.751e-231	721.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3N6F3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
HKD1_k127_2176788_3	1267005.KB911256_gene1809	4.205e-97	323.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,3N6NR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_2176788_4	1267005.KB911256_gene1811	1.026e-52	188.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,3N6A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_2187157_9	1411123.JQNH01000001_gene1214	0.0002061	44.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
HKD1_k127_2187157_0	1267005.KB911257_gene1010	9.278e-261	807.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,3N6B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD1_k127_2187157_8	639283.Snov_3810	1.419e-52	188.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,3EZMV@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0093)	MA20_24805	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
HKD1_k127_2187157_1	670307.HYPDE_39713	1.028e-144	466.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,3N63I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_2187157_2	1267005.KB911257_gene1007	1.104e-144	465.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria,3N7J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	MA20_24795	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD1_k127_2187157_7	991905.SL003B_0070	6.151e-54	196.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,4BQAC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD1_k127_2187157_3	1267005.KB911257_gene1005	1.637e-121	396.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3N6MF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_2187157_6	1437448.AZRT01000037_gene3253	5.323e-59	213.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,1J1U7@118882|Brucellaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD1_k127_2187157_4	1267005.KB911257_gene1003	4.801e-100	331.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,3N6P9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD1_k127_2187157_5	1267005.KB911257_gene1002	1.938e-61	216.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,3N74W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HKD1_k127_2187407_0	1267005.KB911256_gene1870	0.0	1414.0	COG2352@1|root,COG2352@2|Bacteria	2|Bacteria	C	phosphoenolpyruvate carboxylase activity	-	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD1_k127_2187407_6	670307.HYPDE_38933	3.138e-174	554.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TTC8@28211|Alphaproteobacteria,3N9GC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	mtkB	-	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_2187407_4	1267005.KB911256_gene1872	2.849e-207	655.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3N66U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	mtkA	-	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_2187407_7	1267005.KB911256_gene1873	4.55e-167	530.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_2187407_5	717785.HYPMC_4396	8.707e-205	644.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_2187407_13	717785.HYPMC_4397	2.516e-81	276.0	COG2197@1|root,COG2197@2|Bacteria,1REG5@1224|Proteobacteria,2U8UP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	sgaR	-	-	ko:K07685	ko02020,map02020	M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_2187407_12	1120956.JHZK01000023_gene1143	1.251e-96	330.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,1JNAG@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD1_k127_2187407_14	1267005.KB911257_gene720	3.007e-65	232.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2TURK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD1_k127_2187407_1	1267005.KB911256_gene1863	8.916e-315	972.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD1_k127_2187407_2	1267005.KB911255_gene2676	4.203e-247	768.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,3N6GT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_32420	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD1_k127_2187407_8	1267005.KB911255_gene2675	5.202e-146	468.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,3N64V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	MA20_32425	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
HKD1_k127_2187407_11	1267005.KB911255_gene2674	1.328e-110	363.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TTZY@28211|Alphaproteobacteria,3N71S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Bacterial transglutaminase-like N-terminal region	MA20_32430	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_2187407_10	1267005.KB911255_gene2673	2.379e-115	376.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2U09K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Proteasome-type protease	MA20_32445	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
HKD1_k127_2187407_3	717785.HYPMC_4296	1.404e-226	708.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,3N68G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	rkpK	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_2187407_9	717785.HYPMC_4373	1.897e-125	412.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2TSKS@28211|Alphaproteobacteria,3N6EG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD1_k127_2196523_11	1031288.AXAA01000044_gene1985	8.156e-22	97.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,36F0S@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HKD1_k127_2196523_9	670307.HYPDE_35093	2.684e-28	116.0	COG0790@1|root,COG0790@2|Bacteria,1N8SR@1224|Proteobacteria,2UFFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	MA20_36515	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD1_k127_2196523_1	1267005.KB911262_gene3364	2.542e-142	461.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,3N6IJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2196523_6	1267005.KB911262_gene3362	3.916e-58	206.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,2U088@28211|Alphaproteobacteria,3N7BA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	MA20_30625	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_2196523_4	1267005.KB911262_gene3361	1.094e-77	284.0	COG0500@1|root,COG2226@2|Bacteria,1REUM@1224|Proteobacteria,2U75Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	btaB	-	-	ko:K13623	ko00564,map00564	-	R09073	RC00003,RC02308	ko00000,ko00001	-	-	-	Methyltransf_23,Methyltransf_25
HKD1_k127_2196523_0	1267005.KB911262_gene3360	1.125e-174	557.0	COG5379@1|root,COG5379@2|Bacteria,1MWG8@1224|Proteobacteria,2TQKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase	btaA	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
HKD1_k127_2196523_7	1211777.BN77_0435	1.28e-50	192.0	COG0500@1|root,COG0500@2|Bacteria,1RKZB@1224|Proteobacteria,2UAVQ@28211|Alphaproteobacteria,4BB12@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_2196523_10	1267005.KB911259_gene3928	3.48e-27	119.0	COG1278@1|root,COG1278@2|Bacteria,1N59P@1224|Proteobacteria,2UCSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_2196523_5	1122132.AQYH01000003_gene3182	9.215e-59	213.0	COG0500@1|root,COG2226@2|Bacteria,1RKPU@1224|Proteobacteria,2UDN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_2196523_3	316055.RPE_2334	5.137e-86	299.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JQV4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	MA20_31570	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_7,PAS_8
HKD1_k127_2196523_2	1230476.C207_02190	3.541e-95	321.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JT1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Bacterial signalling protein N terminal repeat	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS_4,PAS_7,PAS_8,dCache_1
HKD1_k127_2209489_1	1230343.CANP01000020_gene1405	3.06e-80	280.0	COG1752@1|root,COG1752@2|Bacteria,1PEXI@1224|Proteobacteria,1RXDF@1236|Gammaproteobacteria,1JE0I@118969|Legionellales	118969|Legionellales	S	Patatin phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3734,Patatin
HKD1_k127_2209489_0	670307.HYPDE_30863	5e-324	996.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,3N6EJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_2209489_4	1415166.NONO_c19640	8.969e-05	51.0	COG4691@1|root,COG4691@2|Bacteria,2HIAP@201174|Actinobacteria,4G3IG@85025|Nocardiaceae	201174|Actinobacteria	S	Plasmid stability protein	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
HKD1_k127_2209489_3	102232.GLO73106DRAFT_00033570	1.163e-07	55.0	COG4374@1|root,COG4374@2|Bacteria,1G8PQ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_2214511_14	395965.Msil_3165	6.021e-05	50.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_2214511_7	1134912.AJTV01000008_gene1870	1.869e-81	274.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_2214511_12	670307.HYPDE_27863	1.368e-10	67.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_2214511_11	443598.AUFA01000004_gene5223	7.223e-12	70.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria,3K16V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_2214511_5	1211115.ALIQ01000139_gene1295	1.376e-97	331.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,2TTFW@28211|Alphaproteobacteria,3NC2G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Peptidase family M50	-	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50
HKD1_k127_2214511_2	1267005.KB911259_gene3689	1.395e-160	521.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
HKD1_k127_2214511_4	1267005.KB911259_gene3690	7.497e-104	349.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,3N7Y6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_2214511_9	582899.Hden_0966	4.846e-56	203.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,3N72C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_2214511_10	1267005.KB911259_gene3692	1.837e-51	191.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,3N75M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_2214511_1	717785.HYPMC_2770	4.253e-168	542.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,3N6N9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_2214511_6	717785.HYPMC_2771	3.628e-85	286.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,3N6W0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_2214511_3	1267005.KB911259_gene3695	5.89e-119	393.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,3N6TI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_2214511_8	1336243.JAEA01000011_gene3117	1.487e-71	246.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,1JUHU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_2214511_0	1267005.KB911259_gene3697	4.224e-238	743.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,3N69A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_2214511_13	1267005.KB911258_gene55	2.481e-10	61.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2215500_3	272560.BPSS2209	3.985e-19	96.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2VUHR@28216|Betaproteobacteria,1KHK9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HKD1_k127_2215500_0	717785.HYPMC_2545	2.431e-67	239.0	COG1664@1|root,COG1664@2|Bacteria,1N702@1224|Proteobacteria,2UN6M@28211|Alphaproteobacteria,3N8DS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cadherin-like	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,Cadherin_3
HKD1_k127_2215500_1	582899.Hden_0873	1.187e-40	163.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_2215500_4	670307.HYPDE_33998	2.892e-09	63.0	COG5496@1|root,COG5496@2|Bacteria,1RIY6@1224|Proteobacteria,2U68P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_2254489_8	1380355.JNIJ01000101_gene1415	1.418e-33	139.0	COG3637@1|root,COG3637@2|Bacteria,1NJWW@1224|Proteobacteria,2UD8G@28211|Alphaproteobacteria,3JSHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	OmpA-like transmembrane domain	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD1_k127_2254489_0	670307.HYPDE_38393	2.016e-231	733.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske
HKD1_k127_2254489_4	1382306.JNIM01000001_gene4001	2.546e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,2G8JD@200795|Chloroflexi	200795|Chloroflexi	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_2254489_5	1123229.AUBC01000015_gene4622	5.994e-64	231.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,3JSBB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the pirin family	MA20_23765	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_2254489_2	1267005.KB911263_gene1326	5.541e-80	273.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the pirin family	MA20_23765	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_2254489_11	1173020.Cha6605_1330	1.268e-09	64.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	ccpN	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	CBS,HTH_11,HTH_Crp_2,MS_channel,Pyr_redox_2,cNMP_binding
HKD1_k127_2254489_7	1267005.KB911260_gene3498	1.739e-40	157.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TXAH@28211|Alphaproteobacteria,3N9DW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9
HKD1_k127_2254489_6	1267005.KB911260_gene3498	8.723e-46	173.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TXAH@28211|Alphaproteobacteria,3N9DW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9
HKD1_k127_2254489_9	1122180.Lokhon_02553	1.199e-20	97.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2P9F0@245186|Loktanella	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_4,PAS_7
HKD1_k127_2254489_3	1267005.KB911255_gene2646	1.195e-71	253.0	COG2207@1|root,COG2207@2|Bacteria,1QUXX@1224|Proteobacteria,2U3YA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AraC-binding-like domain	MA20_34385	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HKD1_k127_2254489_1	1121028.ARQE01000011_gene230	2.746e-91	305.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,2TRD4@28211|Alphaproteobacteria,2PKJ2@255475|Aurantimonadaceae	28211|Alphaproteobacteria	J	tRNA synthetases class II (D, K and N)	genX	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
HKD1_k127_2261580_6	622637.KE124774_gene2530	5.897e-15	76.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2U4Q3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_2261580_4	1336243.JAEA01000002_gene2766	8.226e-19	89.0	2EHHF@1|root,33B9C@2|Bacteria,1N3NN@1224|Proteobacteria,2UC59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2261580_2	1380394.JADL01000020_gene1816	8.514e-59	213.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2JPN3@204441|Rhodospirillales	204441|Rhodospirillales	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_2261580_3	716928.AJQT01000079_gene992	7.915e-37	141.0	COG4274@1|root,COG4274@2|Bacteria,1N83R@1224|Proteobacteria	1224|Proteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_2261580_5	1144312.PMI09_00169	9.48e-19	88.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,2V347@28211|Alphaproteobacteria,4BK4E@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2261580_0	765911.Thivi_0989	1.048e-185	598.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales	135613|Chromatiales	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD1_k127_2261580_1	426117.M446_2875	1.086e-62	223.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,1JZHP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2,Acyltransferase,PP-binding
HKD1_k127_2279133_1	670307.HYPDE_38998	9.032e-64	223.0	COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria,3N746@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
HKD1_k127_2279133_2	717785.HYPMC_4410	1.169e-41	159.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,3N72U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD1_k127_2279133_3	1267005.KB911257_gene956	5.584e-39	156.0	COG3064@1|root,COG3064@2|Bacteria,1NAWA@1224|Proteobacteria,2TSQY@28211|Alphaproteobacteria,3N7CW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_2279133_0	1267005.KB911257_gene955	0.0	1305.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,3N66S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
HKD1_k127_2283951_2	663610.JQKO01000001_gene1109	1.802e-15	84.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3NAFH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Trypsin	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_2283951_0	1298867.AUES01000002_gene1568	1.694e-129	425.0	COG0654@1|root,COG0654@2|Bacteria,1MUEW@1224|Proteobacteria,2TUIB@28211|Alphaproteobacteria,3JU6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_2283951_1	1510531.JQJJ01000012_gene1558	4.197e-25	110.0	COG5653@1|root,COG5653@2|Bacteria,1MVAR@1224|Proteobacteria,2TTKY@28211|Alphaproteobacteria,3JRH4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_2287685_0	323097.Nham_2814	3.652e-188	593.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JR83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_2287685_3	582899.Hden_3197	3.069e-118	389.0	COG0332@1|root,COG0332@2|Bacteria,1N6Z0@1224|Proteobacteria,2U1G4@28211|Alphaproteobacteria,3N9GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	fabH2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_2287685_2	1089544.KB912942_gene1762	1.645e-127	432.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4E0F3@85010|Pseudonocardiales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_2287685_4	292415.Tbd_0367	2.126e-92	319.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2287685_1	1282876.BAOK01000002_gene565	4.457e-149	477.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,4BPRI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_2304927_2	1267005.KB911259_gene3860	2.464e-97	328.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,3N704@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_2304927_5	1267005.KB911259_gene3861	5.113e-50	198.0	COG1051@1|root,COG1051@2|Bacteria,1N0YW@1224|Proteobacteria,2UC2E@28211|Alphaproteobacteria,3N7BK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_2304927_4	1267005.KB911259_gene3862	4.044e-55	199.0	COG3153@1|root,COG3153@2|Bacteria,1RD0C@1224|Proteobacteria,2U7AS@28211|Alphaproteobacteria,3N79B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
HKD1_k127_2304927_3	670307.HYPDE_31383	2.588e-56	202.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,2UA1B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
HKD1_k127_2304927_1	1038859.AXAU01000010_gene1885	2.525e-151	484.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3JRKK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	MA20_17020	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD1_k127_2304927_0	1267005.KB911259_gene3863	4.259e-226	704.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,3N6FW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_2320352_0	670307.HYPDE_35973	1.381e-234	732.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,3N6CN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_2320352_3	1236501.BAJU01000040_gene2720	8.863e-49	181.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2UBXA@28211|Alphaproteobacteria,2JTIZ@204441|Rhodospirillales	204441|Rhodospirillales	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_2320352_2	414684.RC1_4118	2.425e-54	198.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,2JTHR@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_2320352_4	717785.HYPMC_0959	2.181e-25	112.0	2C2M3@1|root,316DE@2|Bacteria,1R7TZ@1224|Proteobacteria,2UB1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_16080	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2320352_5	1051632.TPY_0663	4.551e-13	72.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia	186801|Clostridia	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
HKD1_k127_2320352_1	1230476.C207_03398	2.562e-183	594.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,3JXPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_2350230_4	1267005.KB911256_gene1777	9.95e-55	194.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,3N71E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD1_k127_2350230_5	1267005.KB911256_gene1776	2.124e-54	196.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,3N73P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_2350230_0	670307.HYPDE_28013	1.054e-240	769.0	2CYKW@1|root,32T4E@2|Bacteria,1N3JA@1224|Proteobacteria,2UEZF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2350230_6	1267005.KB911265_gene3648	7.888e-32	128.0	COG0664@1|root,COG0664@2|Bacteria,1N6WV@1224|Proteobacteria	1224|Proteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_2350230_2	1267005.KB911256_gene1459	5.804e-105	356.0	COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,2TW6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_2350230_1	553385.JEMF01000078_gene627	1.154e-114	378.0	COG0596@1|root,COG0596@2|Bacteria,1RBH1@1224|Proteobacteria,1S2GJ@1236|Gammaproteobacteria,1XJ39@135619|Oceanospirillales	135619|Oceanospirillales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	ko:K19707	-	-	-	-	ko00000,ko03021	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_2350230_3	1173264.KI913950_gene4558	1.664e-93	316.0	COG0614@1|root,COG0614@2|Bacteria,1G1W1@1117|Cyanobacteria,1H7T1@1150|Oscillatoriales	1117|Cyanobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_2386299_2	717785.HYPMC_4416	2.013e-140	450.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,3N81A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_2386299_4	1267005.KB911257_gene691	1.617e-33	137.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,3N7CI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	bolA	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
HKD1_k127_2386299_3	1267005.KB911257_gene690	9.59e-89	297.0	COG0484@1|root,COG0484@2|Bacteria,1QU4R@1224|Proteobacteria,2TVZG@28211|Alphaproteobacteria,3N6VE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	heat shock protein DnaJ	dnaJ2	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_2386299_1	1267005.KB911257_gene689	6.282e-197	616.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,3N62H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cobaltochelatase CobS subunit N terminal	cobS	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
HKD1_k127_2386299_0	1267005.KB911257_gene687	6.892e-284	883.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,3N691@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	cobalt chelatase	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
HKD1_k127_2386299_5	316057.RPD_0285	4.895e-07	55.0	COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria,3JTKP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	-	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
HKD1_k127_2402317_7	1267005.KB911255_gene2513	1.918e-62	217.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,3N6MB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidase M23	MA20_20375	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_2402317_9	717785.HYPMC_4690	1.442e-38	147.0	2DGI2@1|root,2ZW2M@2|Bacteria,1P4XI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2402317_0	1267005.KB911255_gene2512	0.0	1369.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,3N6DT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_2402317_8	670307.HYPDE_41738	1.565e-45	175.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,3N76S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
HKD1_k127_2402317_5	1267005.KB911255_gene2508	1.675e-87	300.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,3N6VK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD1_k127_2402317_3	1267005.KB911255_gene2507	2.624e-171	543.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,3N6BP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_2402317_12	670307.HYPDE_41723	3.727e-21	102.0	COG1426@1|root,COG1426@2|Bacteria	2|Bacteria	S	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_25,HTH_3
HKD1_k127_2402317_1	717785.HYPMC_4904	0.0	1086.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,3N6EH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_2402317_2	1267005.KB911255_gene2505	2.024e-217	680.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,3N65I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_2402317_4	1267005.KB911255_gene2504	4.723e-95	317.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,3N68J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_2402317_10	1267005.KB911259_gene4037	1.085e-36	144.0	2BZQA@1|root,3302G@2|Bacteria,1QVKI@1224|Proteobacteria,2TWHK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of Unknown Function (DUF930)	-	-	-	-	-	-	-	-	-	-	-	-	DUF930
HKD1_k127_2402317_13	46234.ANA_C10547	5.767e-06	57.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
HKD1_k127_2402317_11	1267005.KB911263_gene1325	6.401e-22	101.0	COG5490@1|root,COG5490@2|Bacteria,1Q86G@1224|Proteobacteria,2VECD@28211|Alphaproteobacteria,3N98J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_2402317_6	1267005.KB911257_gene843	1.412e-65	239.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2TZ1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_244825_5	1267005.KB911263_gene1284	5.697e-112	367.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,3N6PB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HKD1_k127_244825_7	1297865.APJD01000007_gene1772	3.411e-41	155.0	COG5126@1|root,COG5126@2|Bacteria,1N18I@1224|Proteobacteria,2UDV5@28211|Alphaproteobacteria,3JY3B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	DTZ	EF-hand, calcium binding motif	MA20_34420	-	-	-	-	-	-	-	-	-	-	-	EF-hand_1,EF-hand_5,EF-hand_8
HKD1_k127_244825_3	1267005.KB911263_gene1286	1.4e-186	595.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,3N6AH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_244825_6	1267005.KB911263_gene1287	2.068e-42	156.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria,3N74F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD1_k127_244825_4	582899.Hden_1688	9.756e-114	373.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2TR7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	dat	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_244825_1	1267005.KB911263_gene1289	6.297e-261	810.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,3N61P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_244825_0	1267005.KB911263_gene1290	1.018e-288	905.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,3N66N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_244825_2	1267005.KB911263_gene1291	2.506e-198	621.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N69C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
HKD1_k127_2477338_5	1267005.KB911265_gene3626	5.722e-20	96.0	2E3E3@1|root,32YD6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2477338_2	1267005.KB911265_gene3627	4.781e-107	382.0	COG0790@1|root,COG3170@1|root,COG0790@2|Bacteria,COG3170@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3N6X8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
HKD1_k127_2477338_1	1267005.KB911265_gene3628	2.201e-130	422.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,3N695@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_2477338_4	1267005.KB911265_gene3629	2.097e-69	264.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,3N79W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	MA20_19830	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
HKD1_k127_2477338_3	670307.HYPDE_24618	2.117e-106	362.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,3N6YR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ICC-like phosphoesterases	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_2477338_0	1267005.KB911265_gene3631	0.0	1173.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,3N6HF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD1_k127_2477338_6	1267005.KB911265_gene3632	2.945e-12	68.0	2CAZC@1|root,32ZW8@2|Bacteria,1Q6SJ@1224|Proteobacteria,2VCII@28211|Alphaproteobacteria,3N7FQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2489812_2	717785.HYPMC_1285	6.317e-22	96.0	COG5458@1|root,COG5458@2|Bacteria,1N054@1224|Proteobacteria,2UBY1@28211|Alphaproteobacteria,3N78A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1489)	MA20_36070	-	-	-	-	-	-	-	-	-	-	-	DUF1489
HKD1_k127_2489812_0	1267005.KB911260_gene3471	1.075e-167	533.0	COG0079@1|root,COG0079@2|Bacteria,1MWPU@1224|Proteobacteria,2TRV5@28211|Alphaproteobacteria,3N6I9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	hisC1	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2489812_1	1267005.KB911260_gene3473	1.101e-97	334.0	2DBB3@1|root,2Z85F@2|Bacteria,1N6NI@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (4846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4846
HKD1_k127_2513827_7	1255043.TVNIR_1343	1.231e-08	59.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1T5A0@1236|Gammaproteobacteria,1WZ3D@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_2513827_6	648757.Rvan_0930	6.324e-35	136.0	COG0625@1|root,COG0625@2|Bacteria,1NF66@1224|Proteobacteria,2TVE4@28211|Alphaproteobacteria,3N7ZC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Glutathione S-transferase, N-terminal domain	MA20_01250	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
HKD1_k127_2513827_0	648757.Rvan_0607	1.898e-165	532.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2UAAN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_2513827_4	648757.Rvan_0608	3.311e-92	318.0	COG0642@1|root,COG2205@2|Bacteria,1NFHM@1224|Proteobacteria,2U9RU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SSF
HKD1_k127_2513827_5	648757.Rvan_0609	3.119e-60	221.0	COG3437@1|root,COG3437@2|Bacteria,1RIF9@1224|Proteobacteria,2UIHV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2513827_2	1054213.HMPREF9946_03063	1.267e-135	454.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JZAE@204441|Rhodospirillales	204441|Rhodospirillales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD1_k127_2513827_1	1267005.KB911257_gene987	1.976e-143	460.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,3N6YK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	olsB	-	2.3.2.30	ko:K22310	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_5
HKD1_k127_2513827_3	1333998.M2A_0282	2.365e-135	455.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U4KP@28211|Alphaproteobacteria,4BR8T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_7,Response_reg
HKD1_k127_2513852_24	876269.ARWA01000001_gene8	2.753e-10	61.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2TX4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_2513852_22	1123229.AUBC01000011_gene2379	5.866e-23	102.0	2E398@1|root,32Y8V@2|Bacteria,1N7IR@1224|Proteobacteria,2UFHK@28211|Alphaproteobacteria,3K10Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2513852_21	347834.RHE_CH01246	9.479e-25	108.0	2DMI7@1|root,32RQB@2|Bacteria,1R35X@1224|Proteobacteria,2TZYA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SPW repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPW
HKD1_k127_2513852_2	1267005.KB911258_gene320	0.0	1186.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3N7IJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Malic enzyme, NAD binding domain	tme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD1_k127_2513852_1	1267005.KB911257_gene986	0.0	1209.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3N6KE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_2513852_0	1267005.KB911257_gene985	0.0	1381.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,3N6A4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD1_k127_2513852_17	1267005.KB911260_gene3488	1.582e-57	213.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	plpD	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,SmpA_OmlA
HKD1_k127_2513852_11	1267005.KB911256_gene1853	1.985e-96	320.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,3N8E7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_2513852_3	1267005.KB911262_gene3321	6.317e-223	702.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,3N6AR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_2513852_6	670307.HYPDE_41488	3.68e-184	580.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3N6IB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_2513852_14	1267005.KB911262_gene3323	1.16e-68	238.0	COG0589@1|root,COG0589@2|Bacteria,1R9XB@1224|Proteobacteria,2U59E@28211|Alphaproteobacteria,3N73H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	MA20_23830	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_2513852_12	717785.HYPMC_4781	1.516e-90	310.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,3N6NK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Scaffold protein Nfu NifU	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
HKD1_k127_2513852_13	1267005.KB911262_gene3325	1.429e-87	293.0	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,3N7J1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase NAD(P)H nitroreductase	rutE	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HKD1_k127_2513852_19	717785.HYPMC_4779	5.481e-48	181.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,3N7AS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Glycoprotease family	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_2513852_18	582899.Hden_3482	3.627e-51	195.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,3N7BH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_2513852_16	582899.Hden_3483	1.527e-58	206.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,3N703@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_2513852_9	1267005.KB911262_gene3329	8.588e-127	414.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,3N6X1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_2513852_7	1267005.KB911262_gene3330	6.116e-174	557.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,3N69I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_2513852_23	231434.JQJH01000006_gene128	1.058e-10	63.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,3NAQJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_2513852_8	1267005.KB911262_gene3331	1.953e-168	534.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,3N68S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_2513852_20	1267005.KB911262_gene3332	2.696e-41	158.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,3N76N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD1_k127_2513852_10	1267005.KB911262_gene3333	4.139e-120	396.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,3N6UY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
HKD1_k127_2513852_5	1267005.KB911262_gene3334	1.216e-188	608.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,3N67N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_2513852_15	582899.Hden_3490	9.752e-61	214.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria,3N8NE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	MA20_23890	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD1_k127_2513852_4	1429916.X566_17245	1.766e-212	665.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,3JTYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_2638923_1	648757.Rvan_1646	1.037e-158	515.0	COG3596@1|root,COG3596@2|Bacteria,1P6GT@1224|Proteobacteria,2UAIT@28211|Alphaproteobacteria,3N8AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06946	-	-	-	-	ko00000	-	-	-	MMR_HSR1
HKD1_k127_2638923_3	648757.Rvan_1645	8.889e-132	435.0	COG3596@1|root,COG3597@1|root,COG3596@2|Bacteria,COG3597@2|Bacteria,1MV2B@1224|Proteobacteria,2U698@28211|Alphaproteobacteria,3N7IZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
HKD1_k127_2638923_5	349163.Acry_1273	2.059e-16	82.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_2638923_2	886293.Sinac_2022	1.726e-143	463.0	COG0176@1|root,COG0176@2|Bacteria,2IY2M@203682|Planctomycetes	203682|Planctomycetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_2638923_0	383372.Rcas_0710	3.161e-244	764.0	COG0166@1|root,COG0166@2|Bacteria,2G5ZM@200795|Chloroflexi,376U7@32061|Chloroflexia	32061|Chloroflexia	F	glucose-6-phosphate isomerase activity	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_2638923_4	639283.Snov_4443	7.47e-50	183.0	2E7KN@1|root,3322N@2|Bacteria,1N6FH@1224|Proteobacteria,2V697@28211|Alphaproteobacteria,3F06E@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1097
HKD1_k127_2641148_8	717785.HYPMC_0113	7.88e-29	116.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria,3N72P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
HKD1_k127_2641148_6	582899.Hden_0202	3.977e-40	149.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,3N70Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_2641148_5	1267005.KB911256_gene1857	2.03e-56	202.0	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,3N7F2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_2641148_2	717785.HYPMC_0110	2.479e-176	567.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,3N6AZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD1_k127_2641148_4	349163.Acry_0490	5.207e-112	389.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
HKD1_k127_2641148_3	709797.CSIRO_0464	3.698e-162	524.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TV58@28211|Alphaproteobacteria,3JW0H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_2641148_9	504832.OCAR_7274	1.802e-07	53.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TV58@28211|Alphaproteobacteria,3JW0H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_2641148_7	744980.TRICHSKD4_4302	6.943e-34	138.0	COG3247@1|root,COG3247@2|Bacteria,1R63F@1224|Proteobacteria,2U3AR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_2641148_1	582899.Hden_0206	1.006e-179	571.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,3N6EK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD1_k127_2641148_0	582899.Hden_0207	2.188e-183	581.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,3N6KW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_2642193_0	1267005.KB911263_gene1390	4.508e-115	372.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,3N7JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	algC	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_2642193_3	670307.HYPDE_23283	3.458e-80	282.0	COG4252@1|root,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,DUF928
HKD1_k127_2642193_1	670307.HYPDE_31178	1.36e-94	324.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,3N6XH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_43555	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_2642193_2	1267005.KB911263_gene1393	1.812e-89	299.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,3N6A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_2663275_7	1267005.KB911256_gene1979	3.439e-18	84.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,3N62I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	assembly protein	sufB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_2663275_4	670307.HYPDE_35363	3.925e-124	416.0	COG1104@1|root,COG1959@1|root,COG1104@2|Bacteria,COG1959@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,3N6PP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	nifS	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_2663275_6	1267005.KB911256_gene1981	6.356e-43	161.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,3N92S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD1_k127_2663275_3	717785.HYPMC_1092	2.412e-130	419.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,3N6BC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HKD1_k127_2663275_5	1123269.NX02_27255	2.409e-99	334.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,2V1PT@28211|Alphaproteobacteria,2K8V0@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_2663275_2	670307.HYPDE_35373	3.098e-135	440.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria,3N6M8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
HKD1_k127_2663275_1	323098.Nwi_1668	1.284e-203	641.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,3JRMZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD1_k127_2663275_0	1267005.KB911256_gene1988	1.46e-291	922.0	COG2982@1|root,COG2982@2|Bacteria,1QWQT@1224|Proteobacteria,2TX2D@28211|Alphaproteobacteria,3N6W2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HKD1_k127_2728159_2	1267005.KB911260_gene3535	1.75e-98	327.0	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2TRGI@28211|Alphaproteobacteria,3N92Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	OmpW family	ompW	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HKD1_k127_2728159_5	717785.HYPMC_1354	1.068e-68	237.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria,3N6XG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_2728159_4	582899.Hden_2172	4.802e-72	248.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,3N8HB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K09565	ko01503,ko04020,ko04022,ko04217,ko05012,ko05016,ko05145,map01503,map04020,map04022,map04217,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_2728159_7	1449063.JMLS01000009_gene2270	2.892e-24	107.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_2728159_3	1336243.JAEA01000025_gene3051	9.191e-83	280.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,1JU56@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768,ko:K09565	ko04020,ko04022,ko05012,ko05016,ko05145,map04020,map04022,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Pro_isomerase
HKD1_k127_2728159_8	1134912.AJTV01000009_gene1972	7.688e-18	88.0	COG2363@1|root,COG2363@2|Bacteria,1N966@1224|Proteobacteria,2UG11@28211|Alphaproteobacteria,36YV2@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF423)	MA20_21830	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD1_k127_2728159_6	1287116.X734_24925	3.765e-48	177.0	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,2UFXH@28211|Alphaproteobacteria,43KDR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
HKD1_k127_2728159_1	717785.HYPMC_1359	3.208e-157	507.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria,3N687@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_2728159_0	1267005.KB911260_gene3542	4.581e-173	548.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,3N633@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_2743928_2	1502851.FG93_05805	9.05e-23	108.0	COG2764@1|root,COG2764@2|Bacteria,1RJPS@1224|Proteobacteria,2UACG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_2743928_1	1267005.KB911257_gene1095	1.015e-177	567.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,3N63H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_2743928_0	1267005.KB911257_gene1094	0.0	1163.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_2751936_2	1267005.KB911259_gene3938	8.004e-86	290.0	COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2TUNQ@28211|Alphaproteobacteria,3N8FC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	qseB	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2751936_1	1267005.KB911259_gene3939	1.311e-105	358.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2U2V1@28211|Alphaproteobacteria,3N7SG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	qseC	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD1_k127_2751936_3	648885.KB316283_gene2915	6.639e-35	144.0	COG4583@1|root,COG4583@2|Bacteria,1N68D@1224|Proteobacteria,2UDJV@28211|Alphaproteobacteria,1JU74@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit	-	-	1.5.3.1,1.5.99.5	ko:K00305,ko:K22087	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
HKD1_k127_2751936_0	1502851.FG93_00744	0.0	1022.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3JTMR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	soxA	-	1.5.3.1,1.5.99.5	ko:K00302,ko:K22086	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
HKD1_k127_275419_1	1267005.KB911258_gene514	3.184e-304	945.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3N65P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_44845	-	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD1_k127_275419_0	1267005.KB911258_gene513	0.0	1232.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TSUW@28211|Alphaproteobacteria,3N66V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Domain of unknown function (DUF1974)	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
HKD1_k127_275419_4	1415778.JQMM01000001_gene1697	1.489e-08	63.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1JAYU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_275419_6	1121106.JQKB01000005_gene2097	0.0001065	50.0	COG3278@1|root,COG3278@2|Bacteria,1N9ZN@1224|Proteobacteria,2UFRF@28211|Alphaproteobacteria,2JUPS@204441|Rhodospirillales	204441|Rhodospirillales	O	signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_275419_2	1095769.CAHF01000005_gene1551	7.93e-37	149.0	COG0500@1|root,COG2226@2|Bacteria,1R7VM@1224|Proteobacteria	1224|Proteobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
HKD1_k127_275419_5	1547437.LL06_20215	1.283e-06	53.0	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,2UHFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_275419_3	886293.Sinac_5648	4.954e-32	134.0	COG2764@1|root,COG2764@2|Bacteria,2J0HJ@203682|Planctomycetes	203682|Planctomycetes	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_280270_4	582899.Hden_3464	1.942e-37	143.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,3N723@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_280270_1	1267005.KB911257_gene991	3.4e-129	419.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,Mrr_cat
HKD1_k127_280270_3	670307.HYPDE_41443	8.361e-65	225.0	COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,3N929@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_280270_0	1267005.KB911257_gene990	3.607e-130	424.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3N6CR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HKD1_k127_280270_2	717785.HYPMC_4791	4.087e-103	339.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,3N6UF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	peptidase S16	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD1_k127_280270_5	1510531.JQJJ01000004_gene4622	2.963e-20	97.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0434 family	MA20_24965	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD1_k127_2803844_0	1267005.KB911257_gene930	5.786e-276	854.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,3N66E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_2803844_3	1267005.KB911257_gene929	7.686e-79	270.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,3N73Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HKD1_k127_2803844_2	582899.Hden_3292	3.962e-134	441.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2U0GI@28211|Alphaproteobacteria,3N87B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Fic/DOC family N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
HKD1_k127_2803844_1	1267005.KB911257_gene911	4.949e-224	703.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,3N7WD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase family M3	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD1_k127_287498_3	316056.RPC_3210	6.304e-151	485.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3JQZ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	MA20_17385	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_287498_4	1297863.APJF01000001_gene2260	7.529e-89	311.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,3JT9C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	MA20_19340	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD1_k127_287498_1	648757.Rvan_2704	1.717e-255	807.0	COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2TQK2@28211|Alphaproteobacteria,3N7PF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	MA20_17380	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,GDE_C,GDE_N_bis
HKD1_k127_287498_0	670307.HYPDE_29678	6.231e-282	877.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,3N7H6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD1_k127_287498_2	1267005.KB911261_gene2316	5.502e-187	597.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,3N6HC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD1_k127_287498_5	1267005.KB911261_gene2318	4.088e-70	247.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,3N74S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HKD1_k127_287498_6	717785.HYPMC_2532	4.921e-10	60.0	2DDMW@1|root,2ZIM0@2|Bacteria,1NE37@1224|Proteobacteria,2UI5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_287498_7	717785.HYPMC_2532	1.036e-06	57.0	2DDMW@1|root,2ZIM0@2|Bacteria,1NE37@1224|Proteobacteria,2UI5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_299865_1	1002340.AFCF01000050_gene1527	5.579e-116	376.0	COG0075@1|root,COG0075@2|Bacteria,1R4JQ@1224|Proteobacteria,2TV9E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_299865_2	1267005.KB911259_gene3916	3.722e-105	350.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,3N6RJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2189)	MA20_41380	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD1_k127_299865_3	1187851.A33M_1565	8.059e-75	270.0	COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,2TWWY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD1_k127_299865_0	1205680.CAKO01000027_gene4695	2.974e-214	677.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales	204441|Rhodospirillales	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_299865_4	709797.CSIRO_1707	0.0003329	49.0	2BTHG@1|root,301V7@2|Bacteria,1NA06@1224|Proteobacteria,2UHQY@28211|Alphaproteobacteria,3K0YT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3021385_0	1267005.KB911264_gene3192	0.0	1781.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3N648@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_3021385_11	717785.HYPMC_1935	9.209e-23	103.0	COG2938@1|root,COG2938@2|Bacteria,1Q6AE@1224|Proteobacteria,2VCGP@28211|Alphaproteobacteria,3N7CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HKD1_k127_3021385_1	670307.HYPDE_30148	0.0	1090.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,3N6HP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_3021385_6	1267005.KB911264_gene3195	1.213e-106	353.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF502)	MA20_12960	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD1_k127_3021385_8	717785.HYPMC_1932	6.405e-40	165.0	COG3115@1|root,COG3115@2|Bacteria	2|Bacteria	D	cell septum assembly	-	-	-	-	-	-	-	-	-	-	-	-	FliO,SPOR,ZipA_C
HKD1_k127_3021385_2	1267005.KB911264_gene3197	0.0	1009.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,3N620@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_3021385_3	1267005.KB911264_gene3198	8.377e-194	613.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,3N68Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HKD1_k127_3021385_10	1267005.KB911264_gene3199	2.372e-24	114.0	COG0174@1|root,339XI@2|Bacteria	2|Bacteria	E	glutamate-ammonia ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD1_k127_3021385_9	1254432.SCE1572_43270	2.354e-27	122.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria,2YWGV@29|Myxococcales	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD1_k127_3021385_5	582899.Hden_1646	7.865e-126	411.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,3N6MC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD1_k127_3021385_4	717785.HYPMC_1926	1.671e-175	562.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,3N7IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HKD1_k127_3021385_13	526225.Gobs_3619	1.355e-11	68.0	COG1359@1|root,COG1359@2|Bacteria,2GSE1@201174|Actinobacteria,4EX0G@85013|Frankiales	201174|Actinobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HKD1_k127_3045400_5	1366050.N234_10790	1.384e-17	87.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria,1K39I@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_3045400_4	670307.HYPDE_23818	1.257e-43	177.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DUF4388,DnaJ
HKD1_k127_3045400_1	670307.HYPDE_23813	1.523e-186	600.0	2C2CS@1|root,2Z7SK@2|Bacteria,1NCSN@1224|Proteobacteria,2U436@28211|Alphaproteobacteria,3N8HX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3754)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3754
HKD1_k127_3045400_2	717785.HYPMC_0348	1.271e-95	322.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,3N71F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD1_k127_3045400_0	670307.HYPDE_23803	1.637e-252	791.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,3N6BW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
HKD1_k127_3045400_3	886293.Sinac_7041	2.147e-66	243.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	O-antigen_lig,Sulfotransfer_3
HKD1_k127_3045400_6	883080.HMPREF9697_03873	1.248e-05	47.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,3JVTG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
HKD1_k127_3058905_0	670307.HYPDE_31088	0.0	1086.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,3N6Q7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MMPL family	MA20_16090	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD1_k127_3058905_2	1267005.KB911260_gene3580	3.566e-74	256.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,3N8TF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_3058905_1	1122132.AQYH01000008_gene2767	2e-94	316.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B85Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_306341_0	864069.MicloDRAFT_00022000	7.291e-196	618.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria,1JRBC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	dctA	-	-	ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
HKD1_k127_306341_1	1038860.AXAP01000088_gene3664	5.953e-99	344.0	COG3637@1|root,COG3637@2|Bacteria,1R873@1224|Proteobacteria,2U0AY@28211|Alphaproteobacteria,3JQQQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,Omptin,Pom
HKD1_k127_306341_2	1144275.COCOR_05201	9.607e-06	47.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria	1224|Proteobacteria	CH	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_3069792_15	670307.HYPDE_39858	3.983e-43	168.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,3N6GU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_3069792_3	1267005.KB911259_gene3839	4.383e-178	567.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TQVM@28211|Alphaproteobacteria,3N7T4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	dapL	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3069792_7	1267005.KB911257_gene1051	4.505e-134	433.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3069792_12	717785.HYPMC_4537	7.851e-93	309.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,3N6QV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	MA20_24865	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_3069792_0	717785.HYPMC_4539	0.0	1428.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,3N6GV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_3069792_14	1267005.KB911257_gene1055	1.015e-48	181.0	COG5468@1|root,COG5468@2|Bacteria,1MXDR@1224|Proteobacteria,2TUMW@28211|Alphaproteobacteria,3N8WH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly	-	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HKD1_k127_3069792_10	1267005.KB911257_gene1056	6.044e-118	389.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,3N6YC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD1_k127_3069792_8	1123366.TH3_01680	1.389e-125	424.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2JPGW@204441|Rhodospirillales	204441|Rhodospirillales	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_3069792_6	717785.HYPMC_4544	2.394e-150	488.0	COG1072@1|root,COG1072@2|Bacteria,1MV3M@1224|Proteobacteria,2TS7E@28211|Alphaproteobacteria,3N64A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Pantothenic acid kinase	coaA	-	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD1_k127_3069792_16	1267005.KB911257_gene1019	1.252e-31	126.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,3N78B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HKD1_k127_3069792_9	1267005.KB911257_gene1018	5.136e-118	386.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,3N69M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_3069792_11	107635.AZUO01000001_gene135	9.47e-102	338.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,36XJR@31993|Methylocystaceae	28211|Alphaproteobacteria	D	Cellulose biosynthesis protein BcsQ	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_3069792_13	1267005.KB911257_gene1016	1.316e-74	269.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,3N74T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD1_k127_3069792_2	582899.Hden_3281	1.293e-286	893.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,3N67J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_3069792_5	1267005.KB911257_gene1013	1.247e-159	514.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,3N63E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD1_k127_3069792_1	1267005.KB911257_gene1012	3.176e-292	924.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,3N849@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_3069792_4	670307.HYPDE_39748	2.165e-170	539.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TUB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_3069792_17	1411123.JQNH01000001_gene1214	1.775e-18	92.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
HKD1_k127_3071344_2	1267005.KB911257_gene1101	5.707e-131	426.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,3N6EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
HKD1_k127_3071344_1	1049564.TevJSym_af00130	4.173e-134	451.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	DnaJ-class molecular chaperone	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_3071344_6	1492922.GY26_01705	3.927e-21	96.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1J77U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	MerR HTH family regulatory protein	cbpM	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
HKD1_k127_3071344_3	670307.HYPDE_39453	2.852e-129	419.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,3N6DG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_3071344_4	717785.HYPMC_4516	7.298e-103	346.0	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2U5YM@28211|Alphaproteobacteria,3N7DH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD1_k127_3071344_0	1267005.KB911257_gene1096	6.612e-224	701.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,3N6F0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_3071344_5	1410620.SHLA_211c000020	1.062e-26	116.0	COG0322@1|root,COG0322@2|Bacteria,1N84M@1224|Proteobacteria,2UMYJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	excinuclease ABC activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3072108_3	1267005.KB911258_gene496	2.608e-15	76.0	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,3N79E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1476)	MA20_09035	-	-	-	-	-	-	-	-	-	-	-	DUF1476
HKD1_k127_3072108_0	1267005.KB911258_gene495	1.067e-158	503.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,3N6FP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_3072108_2	1238182.C882_1353	1.888e-25	120.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD1_k127_3072108_1	1267005.KB911258_gene492	8.41e-125	402.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,3N6NC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_3072108_4	1267005.KB911258_gene491	8.39e-10	68.0	2FC0Q@1|root,3444U@2|Bacteria,1P1FG@1224|Proteobacteria,2UURN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3086619_1	670307.HYPDE_33128	4.207e-103	341.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N7U7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_3086619_2	1038859.AXAU01000019_gene4832	2.439e-79	274.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2TTIN@28211|Alphaproteobacteria,3JTZ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD1_k127_3086619_0	172088.AUGA01000004_gene3909	7.874e-138	445.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,3JR0V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD1_k127_3086619_4	1267005.KB911262_gene3352	2.587e-30	123.0	2C39R@1|root,32UYY@2|Bacteria,1N8ND@1224|Proteobacteria,2UFIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3086619_3	582899.Hden_1431	4.692e-59	211.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2U0XJ@28211|Alphaproteobacteria,3N76M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	MA20_15885	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3086619_5	395963.Bind_3134	3e-22	102.0	COG4944@1|root,COG4944@2|Bacteria,1MXEV@1224|Proteobacteria,2TQKY@28211|Alphaproteobacteria,3NB4U@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1109)	MA20_15880	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD1_k127_3129882_9	709797.CSIRO_0562	5.8e-06	54.0	COG4763@1|root,COG4763@2|Bacteria,1Q61M@1224|Proteobacteria,2TR19@28211|Alphaproteobacteria,3JS8D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_3129882_3	1125973.JNLC01000011_gene300	1.418e-43	171.0	COG4763@1|root,COG4763@2|Bacteria,1Q61M@1224|Proteobacteria,2TR19@28211|Alphaproteobacteria,3JS8D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_3129882_0	1267005.KB911257_gene984	0.0	1448.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,3N65N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_3129882_4	1211777.BN77_4337	8.239e-33	132.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UCNU@28211|Alphaproteobacteria,4BEAJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_3129882_5	717785.HYPMC_4927	8.39e-21	93.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome	cycA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD1_k127_3129882_7	717785.HYPMC_4927	3.463e-07	54.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome	cycA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD1_k127_3129882_1	582899.Hden_0361	1.147e-198	628.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	de-polymerase	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HKD1_k127_3129882_2	1267005.KB911256_gene1447	3.133e-86	302.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,3N8US@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD1_k127_3142636_13	118166.JH976537_gene4868	6.632e-37	141.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD1_k127_3142636_4	265072.Mfla_0354	1.198e-109	357.0	COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2VVGP@28216|Betaproteobacteria	28216|Betaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD1_k127_3142636_7	316056.RPC_2217	2.796e-81	276.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2TUCA@28211|Alphaproteobacteria,3JQXA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	MA20_18655	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD1_k127_3142636_6	765698.Mesci_1545	3.659e-90	307.0	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VEUG@28211|Alphaproteobacteria,43MPY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_3142636_5	582899.Hden_1852	2.376e-91	311.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,3N7R7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA_1	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_3142636_14	1267005.KB911255_gene2535	1.7e-25	111.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,2U61P@28211|Alphaproteobacteria,3N8UC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_3142636_10	1267005.KB911256_gene1675	5.717e-45	178.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria	1224|Proteobacteria	T	Pentapeptide repeat protein	-	-	-	ko:K15352	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	Pentapeptide
HKD1_k127_3142636_0	1267005.KB911262_gene3345	0.0	1224.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,3N6CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_3142636_11	1267005.KB911262_gene3344	1.696e-40	151.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,3N735@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_3142636_3	717785.HYPMC_4762	2.488e-136	441.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,3N6QH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD1_k127_3142636_9	670307.HYPDE_41588	4.231e-55	196.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,3N72E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_3142636_1	1267005.KB911262_gene3341	0.0	1185.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,3N6B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
HKD1_k127_3142636_8	1267005.KB911262_gene3340	1.799e-62	222.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,3N71Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Protein of unknown function (DUF448)	MA20_23920	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
HKD1_k127_3142636_2	1267005.KB911262_gene3339	4.811e-194	610.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3N6I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD1_k127_3156778_11	582899.Hden_3337	8.512e-67	237.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,3N81Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_3156778_5	670307.HYPDE_40048	4.525e-167	531.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,3N86P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the agmatine deiminase family	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HKD1_k127_3156778_0	1502851.FG93_00697	0.0	1143.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	MA20_24480	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD1_k127_3156778_7	717785.HYPMC_4757	1.667e-130	423.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,3N9CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD1_k127_3156778_6	670307.HYPDE_41618	1.149e-148	476.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,3N7R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_3156778_1	1267005.KB911257_gene758	1.769e-223	696.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,3N65J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_3156778_9	1267005.KB911257_gene759	5.049e-95	314.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2TV8S@28211|Alphaproteobacteria,3N6MZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_3156778_12	582899.Hden_3508	4.15e-60	212.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2U75R@28211|Alphaproteobacteria,3N70R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_3156778_10	670307.HYPDE_41638	6.034e-72	246.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria,3N70X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial SH3 domain homologues	-	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	SH3_4
HKD1_k127_3156778_2	1267005.KB911257_gene762	1.076e-190	598.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3N6JG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3156778_16	1197906.CAJQ02000015_gene218	2.353e-07	59.0	2A70E@1|root,30VVK@2|Bacteria,1NMRD@1224|Proteobacteria,2VCC0@28211|Alphaproteobacteria,3K3E0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4189
HKD1_k127_3156778_8	1267005.KB911257_gene764	7.159e-116	385.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,3N6RU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	UBA THIF-type NAD FAD binding protein	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD1_k127_3156778_3	717785.HYPMC_4748	8.912e-177	559.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,3N80V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Cysteine synthase	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3156778_13	1267005.KB911255_gene2500	5.715e-54	201.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,3N6XF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD1_k127_3156778_4	582899.Hden_3514	4.256e-168	538.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,3N639@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038,ko:K21977	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_3156778_14	1267005.KB911255_gene2498	1.541e-51	188.0	COG0457@1|root,COG0457@2|Bacteria	1267005.KB911255_gene2498|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3191776_5	670307.HYPDE_35813	3.504e-72	246.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,3N73S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	MA20_17975	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD1_k127_3191776_9	883078.HMPREF9695_00332	0.0007838	48.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,3JRW9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD1_k127_3191776_0	1267005.KB911259_gene3893	3.685e-131	424.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,3N67E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HKD1_k127_3191776_1	582899.Hden_2441	2.724e-121	394.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,3N68N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein	MA20_17930	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_3191776_8	485918.Cpin_5172	4.149e-25	113.0	COG3831@1|root,COG3831@2|Bacteria,4PN89@976|Bacteroidetes,1IZR1@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3191776_7	1121033.AUCF01000011_gene1739	1.303e-65	231.0	29P18@1|root,309ZE@2|Bacteria,1RF28@1224|Proteobacteria,2U7EN@28211|Alphaproteobacteria,2JSJF@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3191776_2	717785.HYPMC_1157	4.6e-101	339.0	COG2267@1|root,COG2267@2|Bacteria,1R131@1224|Proteobacteria,2TYX6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_3191776_4	1040989.AWZU01000057_gene5071	2.344e-76	261.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2U5T9@28211|Alphaproteobacteria,3JXSA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_3191776_6	1267005.KB911259_gene3886	6.834e-72	248.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,3N6RG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD1_k127_3191776_3	1267005.KB911259_gene3885	1.007e-89	300.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,3N6TD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_3193181_8	1267005.KB911260_gene3424	1.592e-43	162.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,3N71G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	erpA	-	-	ko:K13628,ko:K15724	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD1_k127_3193181_2	1267005.KB911260_gene3425	3.691e-164	527.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,3N6IN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD1_k127_3193181_0	717785.HYPMC_2693	5.551e-263	821.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,3N694@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_3193181_7	1267005.KB911260_gene3427	3.291e-65	244.0	COG3115@1|root,COG3115@2|Bacteria,1R29S@1224|Proteobacteria,2TZED@28211|Alphaproteobacteria,3N9JD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD1_k127_3193181_3	1267005.KB911260_gene3428	1.451e-132	432.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,3N6TA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
HKD1_k127_3193181_4	582899.Hden_1260	4.239e-100	334.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,3N6TB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD1_k127_3193181_5	648757.Rvan_3076	1.027e-97	326.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,3N6MJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD1_k127_3193181_10	395964.KE386496_gene866	2.549e-14	78.0	COG1826@1|root,COG1826@2|Bacteria,1Q69R@1224|Proteobacteria,2VCG7@28211|Alphaproteobacteria,3NBNH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_3193181_9	670307.HYPDE_29343	2.81e-20	96.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,3N7G7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_3193181_6	648757.Rvan_3079	1.188e-89	303.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,3N6HE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_3193181_1	1267005.KB911260_gene3436	1.729e-186	590.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,3N63J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_3196768_4	1185652.USDA257_c48010	2.295e-21	107.0	COG3904@1|root,COG3904@2|Bacteria,1Q6DI@1224|Proteobacteria,2VCJ8@28211|Alphaproteobacteria,4BI6Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3196768_6	936455.KI421499_gene1915	3.662e-09	60.0	COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2TV32@28211|Alphaproteobacteria,3JRJH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_35415	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_3196768_2	1297863.APJF01000004_gene439	2.214e-93	316.0	COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2TV32@28211|Alphaproteobacteria,3JRJH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_35415	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_3196768_5	648757.Rvan_2664	4.087e-13	75.0	2EI88@1|root,33BZI@2|Bacteria,1NKVH@1224|Proteobacteria,2UMZU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YARHG	-	-	-	-	-	-	-	-	-	-	-	-	YARHG
HKD1_k127_3196768_3	1267005.KB911259_gene3842	1.473e-28	119.0	2EIBB@1|root,33C2R@2|Bacteria,1NH1Q@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3196768_1	670307.HYPDE_34128	1.781e-103	346.0	28N2A@1|root,2ZB84@2|Bacteria,1R8N1@1224|Proteobacteria,2U7C7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_35720	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3196768_0	1267005.KB911259_gene3828	3.319e-297	917.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3N62A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain ATP-binding	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_3203422_0	648757.Rvan_1166	7.197e-79	267.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,3N6R6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_3212596_1	1267005.KB911256_gene2031	5.268e-229	713.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3N6GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_3212596_2	717785.HYPMC_0993	5.049e-169	563.0	COG2989@1|root,COG3266@1|root,COG2989@2|Bacteria,COG3266@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N69H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD1_k127_3212596_4	1267005.KB911256_gene2033	4.462e-139	454.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,3N6ND@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Poly A polymerase head domain	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_3212596_8	1267005.KB911256_gene2034	1.915e-19	100.0	2EPR2@1|root,33HBI@2|Bacteria,1NKAP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3212596_6	717785.HYPMC_0905	8.048e-66	231.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,3N7C1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	NUDIX domain	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_3212596_5	1267005.KB911256_gene2036	1.119e-109	369.0	28NTG@1|root,2ZBS3@2|Bacteria,1N1KZ@1224|Proteobacteria,2TQM9@28211|Alphaproteobacteria,3N819@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3212596_9	1038858.AXBA01000024_gene4010	1.936e-13	76.0	COG3637@1|root,COG3637@2|Bacteria,1RKNU@1224|Proteobacteria,2UBCN@28211|Alphaproteobacteria,3F2AZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD1_k127_3212596_3	1267005.KB911256_gene2037	6.55e-163	516.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,3N69E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD1_k127_3212596_0	1267005.KB911256_gene2038	1.65e-245	774.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3N6ES@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC transporter	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_3212596_7	631454.N177_3236	2.262e-28	117.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,1JNSB@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD1_k127_3229637_21	1280949.HAD_02410	2.908e-54	196.0	COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,43W5H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	HJO	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
HKD1_k127_3229637_18	1267005.KB911255_gene2643	2.046e-72	259.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,2TU8I@28211|Alphaproteobacteria,3N7CU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1
HKD1_k127_3229637_6	1267005.KB911257_gene642	2.574e-226	721.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,3N7IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	biosynthesis protein	lpsB2	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD1_k127_3229637_14	1267005.KB911255_gene2645	1.196e-104	342.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,3N6PM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD1_k127_3229637_3	1123269.NX02_11300	1.429e-271	844.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	-	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	-	R00711	RC00047	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD1_k127_3229637_20	215803.DB30_4817	1.054e-57	205.0	COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,42TFG@68525|delta/epsilon subdivisions,2X52K@28221|Deltaproteobacteria,2Z00X@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF779)	-	-	-	ko:K09959	-	-	-	-	ko00000	-	-	-	DUF779
HKD1_k127_3229637_0	1122604.JONR01000003_gene1388	0.0	1120.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X5SP@135614|Xanthomonadales	135614|Xanthomonadales	T	Putative diguanylate phosphodiesterase	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,PAS_3,PAS_8,PAS_9
HKD1_k127_3229637_23	1267005.KB911256_gene2056	3.474e-41	159.0	2C2M3@1|root,316DE@2|Bacteria,1R7TZ@1224|Proteobacteria,2UE3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3229637_19	1267005.KB911258_gene540	4.418e-72	255.0	COG1881@1|root,COG1881@2|Bacteria,1PHY5@1224|Proteobacteria,2V8XI@28211|Alphaproteobacteria,3N99A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PBP
HKD1_k127_3229637_24	717785.HYPMC_0634	2.637e-38	150.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,3N760@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD1_k127_3229637_5	1267005.KB911256_gene1829	5.905e-233	734.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,3N671@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
HKD1_k127_3229637_26	670307.HYPDE_37393	2.042e-06	53.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,3N671@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
HKD1_k127_3229637_12	582899.Hden_2730	1.747e-116	379.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3N6PA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_3229637_10	717785.HYPMC_0632	2.139e-142	458.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,3N6E4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
HKD1_k127_3229637_13	670307.HYPDE_37408	1.817e-109	363.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,3N8R9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD1_k127_3229637_22	717785.HYPMC_0630	2.755e-48	179.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,3N719@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	cycM	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD1_k127_3229637_1	670307.HYPDE_37418	4.396e-293	914.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N65H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	MA20_18500	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_3229637_2	1267005.KB911255_gene2897	1.141e-283	882.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,3N7Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Extracellular solute-binding protein	yejA	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_3229637_7	670307.HYPDE_37428	4.906e-191	601.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,3N6FD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HKD1_k127_3229637_8	670307.HYPDE_37433	5.362e-191	602.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,3N6JC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yejE	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HKD1_k127_3229637_4	670307.HYPDE_37438	4.388e-266	827.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,3N6DD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HKD1_k127_3229637_17	331869.BAL199_15092	1.804e-76	261.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,4BS5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Glutathione S-transferase, N-terminal domain	gst1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD1_k127_3229637_11	1267005.KB911255_gene2902	2.669e-118	391.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,3N6WK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
HKD1_k127_3229637_9	670307.HYPDE_24153	1.975e-179	574.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,3N6E2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
HKD1_k127_3229637_15	1267005.KB911255_gene2904	5.527e-85	293.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,3N8C3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N,GST_N_2,GST_N_3
HKD1_k127_3229637_16	582899.Hden_0325	1.557e-78	271.0	COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVBA@28211|Alphaproteobacteria,3N776@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Tetratricopeptide repeat	MA20_18455	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
HKD1_k127_3235669_6	582899.Hden_0239	3.671e-58	208.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,3N638@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3235669_0	1267005.KB911256_gene1756	1.962e-201	637.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,3N6CV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3235669_1	1267005.KB911256_gene1661	2.034e-195	625.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,3N62X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_3235669_7	1267005.KB911256_gene1662	1.476e-22	102.0	COG5462@1|root,COG5462@2|Bacteria	2|Bacteria	-	-	MA20_01770	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3235669_2	717785.HYPMC_0328	1.079e-126	413.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,3N6NV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_3235669_3	670307.HYPDE_23703	3.983e-79	267.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2UD3W@28211|Alphaproteobacteria,3N8ND@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_3235669_4	1267005.KB911256_gene1665	1.493e-72	260.0	COG2267@1|root,COG2267@2|Bacteria,1P3EB@1224|Proteobacteria,2UGAS@28211|Alphaproteobacteria,3N8I1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_3235669_5	717785.HYPMC_1563	3.02e-61	214.0	COG0262@1|root,COG0262@2|Bacteria,1RIC3@1224|Proteobacteria,2U93X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Dihydrofolate reductase	dmrA	-	1.5.1.47	ko:K17364	ko00790,map00790	-	R03388	RC01584	ko00000,ko00001,ko01000	-	-	-	DHFR_1
HKD1_k127_3235669_9	1150626.PHAMO_10077	8.793e-19	91.0	2DI18@1|root,301P8@2|Bacteria,1PTHJ@1224|Proteobacteria,2V5D3@28211|Alphaproteobacteria,2JYAW@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3235669_8	670307.HYPDE_33213	4.498e-20	89.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
HKD1_k127_3431741_0	1038858.AXBA01000024_gene4035	2.032e-204	644.0	COG2140@1|root,COG2140@2|Bacteria,1MUZA@1224|Proteobacteria,2TTMU@28211|Alphaproteobacteria,3EYI4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Cupin	-	-	4.1.1.2	ko:K01569	ko00630,ko01100,map00630,map01100	-	R00522	RC00321	ko00000,ko00001,ko01000	-	-	-	Cupin_1
HKD1_k127_3431741_5	1040989.AWZU01000053_gene2323	1.153e-67	239.0	2BZSP@1|root,331XA@2|Bacteria,1R6PZ@1224|Proteobacteria,2TSEG@28211|Alphaproteobacteria,3JSZ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3431741_2	717785.HYPMC_0955	1.346e-141	451.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,3N69F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	two component transcriptional regulator	ctrA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_3431741_7	1267005.KB911259_gene3754	1.197e-41	157.0	2BAE2@1|root,323UI@2|Bacteria,1N2A8@1224|Proteobacteria,2UJ2Q@28211|Alphaproteobacteria,3N7BV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	flagellar export protein FliJ	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3431741_6	1267005.KB911259_gene3756	1.03e-52	187.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,3N74X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1153)	MA20_11245	-	-	-	-	-	-	-	-	-	-	-	DUF1153
HKD1_k127_3431741_1	670307.HYPDE_36053	1.624e-168	538.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,3N697@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_3431741_3	1267005.KB911259_gene3758	5.231e-102	340.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2TV8R@28211|Alphaproteobacteria,3N8F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD1_k127_3431741_4	460265.Mnod_6293	7.846e-97	327.0	COG0582@1|root,COG0582@2|Bacteria,1R7GV@1224|Proteobacteria,2TT06@28211|Alphaproteobacteria,1JUJH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_343835_17	1502851.FG93_05321	6.995e-109	357.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2TU2F@28211|Alphaproteobacteria,3JQVZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	MA20_34480	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_343835_32	717785.HYPMC_1900	3.104e-60	216.0	COG0607@1|root,COG0607@2|Bacteria,1MZG3@1224|Proteobacteria,2U1W0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_343835_35	1267005.KB911258_gene228	1.5e-42	165.0	2CCJC@1|root,31PRJ@2|Bacteria,1R6D1@1224|Proteobacteria,2TV8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_343835_10	1267005.KB911258_gene229	3.333e-139	450.0	COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,2TSUF@28211|Alphaproteobacteria,3N87V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Transport permease protein	MA20_34500	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_343835_18	1267005.KB911258_gene230	1.479e-106	351.0	COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,2TTQM@28211|Alphaproteobacteria,3N8KD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	MA20_34505	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_343835_7	670307.HYPDE_31343	5.612e-160	509.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	MA20_34510	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD1_k127_343835_5	1267005.KB911258_gene233	6.388e-163	524.0	COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,2TRSD@28211|Alphaproteobacteria,3N8CB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	MA20_34515	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_343835_38	670307.HYPDE_31333	2.932e-33	135.0	2BJZ8@1|root,32EC2@2|Bacteria,1RF67@1224|Proteobacteria,2UDD5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2380)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3280
HKD1_k127_343835_14	1267005.KB911258_gene235	2.827e-116	391.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,2TRS0@28211|Alphaproteobacteria,3N8MF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_343835_22	717785.HYPMC_1614	5.142e-100	332.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2TR0G@28211|Alphaproteobacteria,3N785@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_34455	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_343835_26	582899.Hden_1465	8.005e-91	309.0	COG1116@1|root,COG1116@2|Bacteria,1MU6C@1224|Proteobacteria,2TS5F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_343835_31	1267005.KB911258_gene238	2.709e-62	222.0	COG1891@1|root,COG1891@2|Bacteria,1RGX0@1224|Proteobacteria	1224|Proteobacteria	T	Pfam:DUF556	-	-	-	-	-	-	-	-	-	-	-	-	4HFCP_synth
HKD1_k127_343835_39	582899.Hden_1467	2.637e-27	117.0	COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2TRVX@28211|Alphaproteobacteria,3N99H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	4HFCP_synth,FolB
HKD1_k127_343835_33	1267005.KB911258_gene240	5.543e-56	207.0	COG2054@1|root,COG2054@2|Bacteria,1MZY4@1224|Proteobacteria,2UD44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM aspartate glutamate uridylate kinase	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
HKD1_k127_343835_4	107636.JQNK01000009_gene3428	2.598e-180	578.0	COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,2TVC7@28211|Alphaproteobacteria,36X7P@31993|Methylocystaceae	28211|Alphaproteobacteria	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_343835_27	1267005.KB911258_gene241	5.683e-85	285.0	COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,2U8UF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
HKD1_k127_343835_25	582899.Hden_1472	6.925e-91	311.0	COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,2U38R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	TIGRFAM H4MPT-linked C1 transfer pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_A
HKD1_k127_343835_30	1267005.KB911258_gene244	8.041e-69	243.0	COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,2U80I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_343835_21	670307.HYPDE_31273	2.51e-101	331.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2TS35@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
HKD1_k127_343835_28	582899.Hden_1475	2.118e-78	276.0	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2U5HF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	PFAM triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HKD1_k127_343835_13	582899.Hden_1476	5.51e-117	385.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	HJ	Belongs to the RimK family	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
HKD1_k127_343835_8	1267005.KB911258_gene248	1.481e-152	488.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,2U0JJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
HKD1_k127_343835_23	1267005.KB911258_gene249	8.531e-96	329.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,2TRBR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
HKD1_k127_343835_9	670307.HYPDE_31248	1.825e-144	463.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,2U1CR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
HKD1_k127_343835_16	1267005.KB911258_gene251	3.281e-113	382.0	COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,2U1RC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM beta-ribofuranosylaminobenzene 5'-phosphate synthase family	mptG	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_343835_29	670307.HYPDE_31238	3.787e-70	244.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2U9EC@28211|Alphaproteobacteria,3N7EB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD1_k127_343835_34	1267005.KB911258_gene253	2.709e-50	184.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,3N7CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD1_k127_343835_36	1187851.A33M_0845	1.768e-39	152.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,3FEFM@34008|Rhodovulum	28211|Alphaproteobacteria	C	Cytochrome c	cycA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD1_k127_343835_2	1267005.KB911258_gene255	6.844e-204	642.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,3N63X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	biosynthesis protein E	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_343835_37	670307.HYPDE_31218	1.461e-36	143.0	COG0535@1|root,COG0535@2|Bacteria,1N7TR@1224|Proteobacteria,2UFAS@28211|Alphaproteobacteria,3N770@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	pqqD	-	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
HKD1_k127_343835_11	670307.HYPDE_31213	3.9e-134	436.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria,3N6JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06136,ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
HKD1_k127_343835_12	582899.Hden_1487	2.083e-131	426.0	COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2TQX4@28211|Alphaproteobacteria,3N6T4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
HKD1_k127_343835_19	32042.PstZobell_08516	3.297e-105	360.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1Z0FH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_3999	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD1_k127_343835_0	670307.HYPDE_31198	2.62e-288	895.0	COG0369@1|root,COG0369@2|Bacteria,1MWYV@1224|Proteobacteria,2V84D@28211|Alphaproteobacteria,3N952@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
HKD1_k127_343835_1	717785.HYPMC_1640	2.936e-288	899.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,3N6DX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD1_k127_343835_24	582899.Hden_1045	3.081e-92	310.0	COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2U5XM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_18170	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_343835_3	1267005.KB911258_gene264	6.983e-204	648.0	COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,3N67M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
HKD1_k127_343835_6	1267005.KB911258_gene265	3.804e-162	515.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,3N6CT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Sulfate adenylyltransferase	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD1_k127_343835_15	1267005.KB911258_gene266	4.04e-115	377.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria,3N74K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD1_k127_343835_20	717785.HYPMC_1647	8.627e-104	339.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,3N6P7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Cold-shock	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_343835_41	717785.HYPMC_1648	1.819e-08	63.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,3N7BU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD1_k127_3497541_1	670307.HYPDE_41683	9.788e-42	160.0	2D9BM@1|root,32TSZ@2|Bacteria,1RJ7Z@1224|Proteobacteria,2UAMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3497541_0	1282876.BAOK01000001_gene1696	9.694e-113	376.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TRVI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	succinylglutamate desuccinylase	doeB	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HKD1_k127_3497541_2	582899.Hden_2743	1.321e-19	104.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,3N8US@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD1_k127_3503873_3	1038860.AXAP01000039_gene2524	7.373e-83	276.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,3JQNZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_3503873_2	1267005.KB911257_gene1032	3.59e-87	294.0	COG2917@1|root,COG2917@2|Bacteria	2|Bacteria	D	probably involved in intracellular septation	ispZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD1_k127_3503873_4	1267005.KB911257_gene1031	1.105e-76	262.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,3N6RF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD1_k127_3503873_5	717785.HYPMC_4628	7.445e-64	226.0	COG1846@1|root,COG1846@2|Bacteria,1RJRY@1224|Proteobacteria,2UA4D@28211|Alphaproteobacteria,3N8VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_3503873_0	1267005.KB911257_gene1030	3.627e-192	612.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,3N64Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_3503873_1	717785.HYPMC_4633	1.69e-113	369.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_3526392_15	265072.Mfla_0384	4.247e-34	134.0	COG3526@1|root,COG3526@2|Bacteria,1MZ5V@1224|Proteobacteria,2VUXZ@28216|Betaproteobacteria,2KN56@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
HKD1_k127_3526392_17	1038866.KB902824_gene1268	5.817e-20	102.0	COG3064@1|root,COG3064@2|Bacteria,1MXS9@1224|Proteobacteria,2TVG0@28211|Alphaproteobacteria,3JV7X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF1236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1236
HKD1_k127_3526392_3	717785.HYPMC_1381	5.694e-123	408.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,3N8XN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HKD1_k127_3526392_9	1121033.AUCF01000017_gene3786	2.045e-56	212.0	COG0644@1|root,COG0644@2|Bacteria,1RAS8@1224|Proteobacteria,2U5PA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3,NAD_binding_8,Pyr_redox_2
HKD1_k127_3526392_11	1510531.JQJJ01000008_gene4176	1.404e-40	164.0	COG2141@1|root,COG2141@2|Bacteria,1RGXC@1224|Proteobacteria,2UGST@28211|Alphaproteobacteria,3K2S3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3526392_7	717785.HYPMC_1380	4.188e-62	222.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Isoprenylcysteine carboxyl methyltransferase	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
HKD1_k127_3526392_4	582899.Hden_1415	1.674e-107	358.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,3N6SE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Haloacid dehalogenase-like hydrolase	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD1_k127_3526392_6	1267005.KB911258_gene532	2.132e-71	245.0	COG5485@1|root,COG5485@2|Bacteria,1QV2Z@1224|Proteobacteria,2TW9M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD1_k127_3526392_14	420662.Mpe_A3569	2.037e-36	147.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,2VSDU@28216|Betaproteobacteria,1KMAJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD1_k127_3526392_5	1267005.KB911258_gene531	1.381e-98	324.0	COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,2TTF2@28211|Alphaproteobacteria,3N8BF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_3526392_2	670307.HYPDE_30973	1.521e-126	413.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,2TVMQ@28211|Alphaproteobacteria,3N753@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD1_k127_3526392_8	582899.Hden_1827	4.774e-62	223.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,3N6Z2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD1_k127_3526392_10	670307.HYPDE_30998	1.172e-51	187.0	COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,2UF42@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
HKD1_k127_3526392_1	1267005.KB911258_gene520	7.98e-220	686.0	COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2TRYK@28211|Alphaproteobacteria,3N7XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_3526392_12	1267005.KB911258_gene519	6.862e-40	150.0	COG0236@1|root,COG0236@2|Bacteria,1NHZ9@1224|Proteobacteria,2UK27@28211|Alphaproteobacteria,3N8Y5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	nodF	-	-	ko:K02078,ko:K14661	-	-	-	-	ko00000,ko00001,ko01000	-	-	-	PP-binding
HKD1_k127_3526392_0	1267005.KB911258_gene518	1.715e-253	793.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3N6FI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_3526392_19	670307.HYPDE_31638	4.449e-13	68.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2U1A0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD1_k127_3528863_1	1187851.A33M_3645	1.404e-133	440.0	COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,2TTPI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Choloylglycine hydrolase	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
HKD1_k127_3528863_0	1267005.KB911256_gene1747	8.675e-219	690.0	COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,2TS75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Thiol oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HKD1_k127_3528863_2	1267005.KB911256_gene1749	1.957e-125	407.0	COG3487@1|root,COG3487@2|Bacteria,1MX5H@1224|Proteobacteria,2TRMF@28211|Alphaproteobacteria,3N8AX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Imelysin	irpA	-	-	ko:K07231	-	-	-	-	ko00000	-	-	-	Peptidase_M75
HKD1_k127_3542686_9	1499680.CCFE01000011_gene770	6.238e-08	55.0	COG0702@1|root,COG0702@2|Bacteria,1V112@1239|Firmicutes,4HEVN@91061|Bacilli,1ZG8I@1386|Bacillus	91061|Bacilli	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,HIM1,NAD_binding_10
HKD1_k127_3542686_1	1267005.KB911256_gene1670	7.26e-180	570.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2U21E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD1_k127_3542686_5	43989.cce_4306	1.099e-107	366.0	COG0277@1|root,COG0277@2|Bacteria,1GARH@1117|Cyanobacteria	1117|Cyanobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
HKD1_k127_3542686_0	717785.HYPMC_1530	7.108e-263	824.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria,3N6V9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cellulose synthase	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2,PilZ
HKD1_k127_3542686_6	582899.Hden_0497	1.256e-92	321.0	COG1566@1|root,COG1566@2|Bacteria,1RJ6W@1224|Proteobacteria,2U0PR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0845 membrane-fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
HKD1_k127_3542686_2	1267005.KB911263_gene1356	1.843e-159	513.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,3N649@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	MA20_22065	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
HKD1_k127_3542686_3	1267005.KB911263_gene1357	2.585e-144	470.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,3N63T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_3542686_7	1110502.TMO_2065	3.372e-74	254.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,2JPV7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_3542686_8	1547437.LL06_22410	4.591e-19	89.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,2UFM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Transglycosylase-associated protein	MA20_01300	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_3542686_4	717785.HYPMC_0561	3.934e-130	429.0	COG2304@1|root,COG4961@1|root,COG2304@2|Bacteria,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria,3N7FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad,VWA
HKD1_k127_358385_3	1267005.KB911258_gene553	4.039e-25	109.0	2DFJJ@1|root,2ZS44@2|Bacteria,1P6UQ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_358385_0	670307.HYPDE_30888	0.0	1828.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,3N6ID@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_358385_1	1267005.KB911258_gene556	8.098e-75	253.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,3N6TK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_3608177_0	78245.Xaut_2127	1.395e-152	489.0	COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,2TTPI@28211|Alphaproteobacteria,3EY1Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
HKD1_k127_3608177_1	582899.Hden_1974	2.409e-138	451.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,3N6FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
HKD1_k127_3608177_2	1122218.KB893654_gene1962	1.453e-64	228.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,1JTJK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	PFAM ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD1_k127_3614128_29	648757.Rvan_2302	0.0002984	50.0	2DSM1@1|root,33GKK@2|Bacteria,1NPGY@1224|Proteobacteria,2UM4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	BA14K-like protein	-	-	-	-	-	-	-	-	-	-	-	-	BA14K
HKD1_k127_3614128_23	670307.HYPDE_33943	1.105e-20	96.0	28XP6@1|root,2ZJK2@2|Bacteria,1NQD6@1224|Proteobacteria,2UKKK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3614128_18	402881.Plav_0737	1.83e-42	162.0	COG5350@1|root,COG5350@2|Bacteria,1RDTX@1224|Proteobacteria,2U71X@28211|Alphaproteobacteria,1JP1U@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	protein tyrosine phosphatase	MA20_42125	-	-	-	-	-	-	-	-	-	-	-	DSPc,Y_phosphatase
HKD1_k127_3614128_30	633149.Bresu_0645	0.0008573	46.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,2KHE0@204458|Caulobacterales	204458|Caulobacterales	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HKD1_k127_3614128_15	279714.FuraDRAFT_1164	1.166e-68	236.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,2KT22@206351|Neisseriales	206351|Neisseriales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD1_k127_3614128_16	1122132.AQYH01000010_gene3972	8.288e-62	218.0	COG0346@1|root,COG0346@2|Bacteria,1RIBY@1224|Proteobacteria,2UAIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3614128_21	1245469.S58_15870	3.123e-26	113.0	2FH9D@1|root,3493Q@2|Bacteria,1ND9G@1224|Proteobacteria,2UJ2Y@28211|Alphaproteobacteria,3K4PQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_3614128_24	1267005.KB911261_gene2256	5.438e-19	91.0	2EVH4@1|root,33NXI@2|Bacteria,1NMN4@1224|Proteobacteria,2UXID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3614128_9	1267005.KB911258_gene305	3.308e-120	394.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TRVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_3614128_7	1267005.KB911258_gene304	3.31e-135	434.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2TSUJ@28211|Alphaproteobacteria,3N8UG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	MA20_38045	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD1_k127_3614128_0	426117.M446_1966	6.029e-235	736.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,1JRY8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD1_k127_3614128_3	1187851.A33M_0270	1.207e-153	505.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2TWGV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major facilitator superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
HKD1_k127_3614128_14	1267005.KB911256_gene2063	5.18e-79	266.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,3N6QT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_3614128_20	1267005.KB911256_gene1753	1.461e-29	122.0	2EP0Y@1|root,33GMT@2|Bacteria,1Q7FE@1224|Proteobacteria,2VDKN@28211|Alphaproteobacteria,3N7CM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD1_k127_3614128_19	717785.HYPMC_0595	1.367e-39	153.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UAFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	rirA	-	-	ko:K13771,ko:K13772	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
HKD1_k127_3614128_6	1267005.KB911256_gene2067	8.04e-147	475.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3614128_11	1267005.KB911256_gene2068	1.088e-91	310.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VF13@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3614128_10	1267005.KB911256_gene2069	2.281e-99	334.0	COG1566@1|root,COG1566@2|Bacteria,1R7IY@1224|Proteobacteria,2U4ET@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_3614128_13	1267005.KB911257_gene856	6.449e-87	310.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,3N6M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD1_k127_3614128_8	1267005.KB911257_gene857	3.248e-126	415.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,3N73Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD1_k127_3614128_4	1267005.KB911256_gene1522	2.966e-150	505.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein conserved in bacteria	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	DUF900,Sel1
HKD1_k127_3614128_28	449447.MAE_44080	9.081e-08	66.0	COG0457@1|root,COG0457@2|Bacteria,1G1QI@1117|Cyanobacteria	1117|Cyanobacteria	F	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_3614128_5	670307.HYPDE_36428	5.736e-149	481.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,3N7TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_3614128_17	1267005.KB911256_gene1521	8.581e-47	178.0	COG2039@1|root,COG2039@2|Bacteria,1MWYG@1224|Proteobacteria,2TU8G@28211|Alphaproteobacteria,3N949@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Pyroglutamyl peptidase	MA20_15835	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
HKD1_k127_3614128_2	1267005.KB911256_gene1520	1.942e-155	503.0	COG5434@1|root,COG5434@2|Bacteria,1N3IG@1224|Proteobacteria,2U0A8@28211|Alphaproteobacteria,3N9IQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Periplasmic copper-binding protein (NosD)	MA20_15840	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
HKD1_k127_3614128_12	1217720.ALOX01000140_gene3573	1.668e-91	315.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2JQI6@204441|Rhodospirillales	204441|Rhodospirillales	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HKD1_k127_3614128_1	1267005.KB911256_gene2073	1.376e-170	552.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N8X3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
HKD1_k127_3670707_5	670307.HYPDE_31783	3.511e-57	201.0	COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,2U93S@28211|Alphaproteobacteria,3N7A1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	gumB	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_3670707_3	582899.Hden_1380	1.21e-113	379.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TSHP@28211|Alphaproteobacteria,3N7M4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like	MA20_36900	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_3670707_0	670307.HYPDE_31793	8.573e-190	606.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,3N6K1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	wcaJ	-	-	ko:K03606,ko:K20997	ko02025,ko05111,map02025,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_3670707_1	582899.Hden_1378	1.95e-122	412.0	COG3307@1|root,COG3307@2|Bacteria,1MWJM@1224|Proteobacteria,2TRG6@28211|Alphaproteobacteria,3N6SI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	O-Antigen ligase	MA20_36890	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_3670707_2	1267005.KB911256_gene1755	1.544e-119	394.0	COG3490@1|root,COG3490@2|Bacteria,1NNS5@1224|Proteobacteria,2TTEJ@28211|Alphaproteobacteria,3N828@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1513)	-	-	-	ko:K09947	-	-	-	-	ko00000	-	-	-	DUF1513
HKD1_k127_3670707_6	1121028.ARQE01000005_gene2974	6.76e-25	117.0	COG3489@1|root,COG3489@2|Bacteria,1MWBW@1224|Proteobacteria,2TRHU@28211|Alphaproteobacteria,2PJTR@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Imelysin	-	-	-	ko:K07338	-	-	-	-	ko00000	-	-	-	Peptidase_M75
HKD1_k127_3670707_4	1168059.KB899087_gene1577	1.175e-63	223.0	COG3487@1|root,COG3487@2|Bacteria,1MX5H@1224|Proteobacteria,2TRMF@28211|Alphaproteobacteria,3EXUN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	Imelysin	irpA	-	-	ko:K07231	-	-	-	-	ko00000	-	-	-	Peptidase_M75
HKD1_k127_3724932_4	1188256.BASI01000001_gene933	1.578e-05	52.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	znuB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD1_k127_3724932_1	1267005.KB911255_gene2455	2.566e-117	384.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,2TQUI@28211|Alphaproteobacteria,3N6PS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD1_k127_3724932_2	1267005.KB911255_gene2456	8.731e-65	225.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,3N72X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	MA20_23250	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
HKD1_k127_3724932_0	1267005.KB911255_gene2457	1.967e-142	468.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3N6HK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_18575	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_3724932_3	1267005.KB911255_gene2458	5.09e-38	147.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	-
HKD1_k127_377243_5	1267005.KB911263_gene1276	7.439e-77	267.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,3N7BI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
HKD1_k127_377243_3	1267005.KB911263_gene1275	5.312e-116	387.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,3N6H1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_377243_2	1267005.KB911263_gene1274	9.539e-129	418.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,3N63G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_377243_9	1267005.KB911258_gene604	1.388e-13	71.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,3N6V4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_377243_6	717785.HYPMC_2055	6.821e-70	240.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,3N6V4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_377243_4	717785.HYPMC_2054	1.676e-95	321.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria,3N6NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_377243_1	1267005.KB911258_gene602	9.044e-145	472.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,3N64S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD1_k127_377243_0	717785.HYPMC_2052	3.06e-223	697.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,3N6JQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_377243_8	670307.HYPDE_30433	7.31e-41	153.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,3N7AA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_377243_7	717785.HYPMC_2049	3.565e-54	192.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,3N68Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_3784260_2	189753.AXAS01000015_gene1212	5.223e-39	145.0	COG3181@1|root,COG3181@2|Bacteria,1N00G@1224|Proteobacteria,2U1MR@28211|Alphaproteobacteria,3JVQD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_3784260_1	318996.AXAZ01000033_gene6447	4.206e-172	542.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,3JVM3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_3784260_0	318996.AXAZ01000033_gene6446	5.808e-237	735.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HKD1_k127_3814522_5	717785.HYPMC_1944	2.55e-13	71.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2UARR@28211|Alphaproteobacteria,3N7CQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HKD1_k127_3814522_1	1267005.KB911255_gene2869	6.646e-248	772.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,3N6CX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD1_k127_3814522_3	1267005.KB911255_gene2870	2.713e-44	165.0	COG5331@1|root,COG5331@2|Bacteria,1N7DJ@1224|Proteobacteria,2U7D2@28211|Alphaproteobacteria,3N96V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD1_k127_3814522_2	1267005.KB911255_gene2871	1.696e-182	580.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,3N6J6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	sun1	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
HKD1_k127_3814522_0	1267005.KB911255_gene2872	0.0	1148.0	COG0500@1|root,COG1181@1|root,COG1181@2|Bacteria,COG2226@2|Bacteria,1N4F5@1224|Proteobacteria,2U4DQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD1_k127_3814522_4	1267005.KB911255_gene2873	6.804e-40	157.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,3N76W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	TspO/MBR family	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD1_k127_3903860_2	1297863.APJF01000028_gene1345	2.066e-10	65.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_3903860_0	1040989.AWZU01000012_gene1302	6.756e-93	318.0	COG0845@1|root,COG0845@2|Bacteria,1R6JG@1224|Proteobacteria,2TU2R@28211|Alphaproteobacteria,3JXAG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3903860_1	582899.Hden_3441	1.036e-58	213.0	COG0683@1|root,COG0683@2|Bacteria,1R6QM@1224|Proteobacteria,2U0C6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_4020376_5	1267005.KB911255_gene3000	1.74e-06	51.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria,3N95K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	WHG domain	MA20_04045	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD1_k127_4020376_2	1267005.KB911256_gene1743	3.325e-86	290.0	COG3921@1|root,COG3921@2|Bacteria,1N3WR@1224|Proteobacteria,2U1ZC@28211|Alphaproteobacteria,3N8P2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Extensin family	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
HKD1_k127_4020376_1	670307.HYPDE_22858	9.875e-107	351.0	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria,3N6PF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_32265	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_4020376_3	670307.HYPDE_22853	1.338e-37	142.0	COG4391@1|root,COG4391@2|Bacteria,1MZNK@1224|Proteobacteria,2UD0H@28211|Alphaproteobacteria,3N77N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zinc-finger domain	MA20_32275	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HKD1_k127_4020376_0	582899.Hden_0061	7.169e-114	383.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,3N7AY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	nah	-	1.14.13.1	ko:K00480	ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R05632,R06915,R06936,R06939	RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HKD1_k127_4020376_4	857293.CAAU_1536	1.817e-16	79.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,36E5Q@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_4024032_0	1267005.KB911262_gene3339	1.756e-222	694.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,3N6I0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD1_k127_4024032_2	1267005.KB911262_gene3338	9.7e-75	257.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,3N6X2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD1_k127_4024032_1	1267005.KB911262_gene3337	6.564e-84	284.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria,3N6ZH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD1_k127_4024032_4	1403819.BATR01000085_gene2473	8.248e-06	57.0	2EF6T@1|root,338ZU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4024032_3	582899.Hden_3491	1.223e-29	118.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,3N68I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_4028009_0	1230476.C207_05876	1.52e-211	672.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,3JQVH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_07830	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8
HKD1_k127_4028009_1	1380355.JNIJ01000001_gene3925	5.608e-87	295.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria,3JQYN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_4028009_7	420324.KI912006_gene8678	6.313e-19	96.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_4028009_2	666684.AfiDRAFT_0897	5.641e-85	291.0	COG1276@1|root,COG1276@2|Bacteria,1P1D5@1224|Proteobacteria,2U4YY@28211|Alphaproteobacteria,3JY3K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Copper resistance protein D	copD	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
HKD1_k127_4028009_6	666684.AfiDRAFT_0898	4.168e-29	120.0	COG2372@1|root,COG2372@2|Bacteria,1N8SS@1224|Proteobacteria,2UFW5@28211|Alphaproteobacteria,3JZRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CopC domain	copC	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
HKD1_k127_4028009_3	670307.HYPDE_29823	8.196e-48	179.0	COG5400@1|root,COG5400@2|Bacteria,1P5Z9@1224|Proteobacteria,2UXRE@28211|Alphaproteobacteria,3N98Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	conserved protein UCP033924	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4028009_5	1267005.KB911256_gene1939	2.062e-45	165.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,3N6SD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD1_k127_4030731_3	670307.HYPDE_40948	1.179e-63	219.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,3N6HD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_4030731_0	1267005.KB911257_gene1121	4.456e-154	491.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,3N7I2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase	hbdA	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_4030731_7	1042209.HK44_009930	2.002e-10	62.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,1S31J@1236|Gammaproteobacteria,1YP51@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD1_k127_4030731_1	1472716.KBK24_0136060	1.046e-67	247.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2VK34@28216|Betaproteobacteria,1KGBV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD1_k127_4030731_4	1229172.JQFA01000002_gene3803	5.172e-63	233.0	COG0625@1|root,COG0625@2|Bacteria,1G438@1117|Cyanobacteria,1HF2X@1150|Oscillatoriales	1117|Cyanobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD1_k127_4030731_5	543728.Vapar_3360	5.116e-51	190.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,4AFCW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_4030731_6	224911.27349096	6.691e-38	150.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3JYB5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_4030731_2	1234364.AMSF01000016_gene1656	1.114e-63	224.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,1X6JY@135614|Xanthomonadales	135614|Xanthomonadales	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_4030731_8	652103.Rpdx1_3885	6.399e-10	61.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2UF3V@28211|Alphaproteobacteria,3JR0Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HKD1_k127_4034916_0	1267005.KB911255_gene2600	2.09e-164	519.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,3N61I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_4034916_6	1267005.KB911255_gene2601	1.339e-88	298.0	COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,2TUD4@28211|Alphaproteobacteria,3N79T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	MA20_24580	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_4034916_4	1267005.KB911255_gene2602	8.258e-105	349.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,3N70D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD1_k127_4034916_7	582899.Hden_3379	2.702e-38	146.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2UBQW@28211|Alphaproteobacteria,3N96S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD1_k127_4034916_2	717785.HYPMC_4692	6.998e-115	375.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,3N6BA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_4034916_5	670307.HYPDE_40743	9.587e-104	343.0	COG0335@1|root,COG3743@1|root,COG0335@2|Bacteria,COG3743@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3N6WT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_4034916_1	1267005.KB911255_gene2612	1.131e-146	469.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,3N64D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_4034916_3	1267005.KB911255_gene2613	6.766e-111	364.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,3N6FU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_4034916_8	1210884.HG799472_gene14826	2.018e-07	53.0	COG0367@1|root,COG0367@2|Bacteria	2|Bacteria	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_4044643_15	224911.27355831	3.401e-15	75.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,3K1QP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD1_k127_4044643_12	1267005.KB911256_gene1960	5.837e-47	180.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
HKD1_k127_4044643_3	670307.HYPDE_36823	9.445e-233	727.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,3N6IF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_4044643_11	670307.HYPDE_36818	2.069e-65	227.0	COG5480@1|root,COG5480@2|Bacteria,1RISQ@1224|Proteobacteria,2U9NW@28211|Alphaproteobacteria,3N71I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1036)	MA20_03870	-	-	-	-	-	-	-	-	-	-	-	DUF1036
HKD1_k127_4044643_10	1267005.KB911256_gene1963	4.064e-101	340.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,3N7NE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD1_k127_4044643_13	1267005.KB911256_gene1965	7.261e-33	131.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,3N7B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
HKD1_k127_4044643_7	1267005.KB911256_gene1966	2.698e-139	449.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,3N6TG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4044643_9	670307.HYPDE_36788	1.69e-120	404.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,3N6UQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD1_k127_4044643_4	1267005.KB911256_gene1968	4.201e-206	657.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N69H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD1_k127_4044643_2	670307.HYPDE_36773	3.444e-256	799.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N6KQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	tacA	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
HKD1_k127_4044643_0	1267005.KB911256_gene1970	1.266e-301	934.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,3N65U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	oligoendopeptidase	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD1_k127_4044643_1	1267005.KB911256_gene1972	4.624e-298	925.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,3N64N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD1_k127_4044643_5	648757.Rvan_0068	1.014e-188	602.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD1_k127_4044643_18	670307.HYPDE_27003	2.985e-11	66.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD1_k127_4044643_17	392499.Swit_3731	6.306e-13	71.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,2K7CP@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD1_k127_4044643_16	582899.Hden_1055	2.768e-13	75.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_4044643_8	1267005.KB911259_gene3790	4.067e-123	407.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,3N7VN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HKD1_k127_4044643_6	582899.Hden_2632	3.032e-172	546.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,3N61J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntAA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_4062088_4	1123508.JH636443_gene4618	1.36e-09	59.0	COG3832@1|root,COG3832@2|Bacteria,2J08M@203682|Planctomycetes	203682|Planctomycetes	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_4062088_0	1267005.KB911257_gene1134	3.804e-145	472.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,3N72N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FL	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
HKD1_k127_4062088_5	935840.JAEQ01000013_gene979	2.249e-07	60.0	COG1873@1|root,COG1873@2|Bacteria,1N6X0@1224|Proteobacteria,2TXGD@28211|Alphaproteobacteria,43HY7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_4062088_3	1458357.BG58_28150	3.658e-33	142.0	COG4319@1|root,COG4319@2|Bacteria,1QDMU@1224|Proteobacteria,2WDSJ@28216|Betaproteobacteria,1KAX8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_4062088_1	1089551.KE386572_gene3913	4.387e-92	313.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD1_k127_4062088_2	717785.HYPMC_0106	6.131e-75	267.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,3N6TP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_4107469_8	1333998.M2A_0909	2.162e-31	124.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,4BPRI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_4107469_3	1267005.KB911263_gene1365	3.69e-95	328.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2UAKC@28211|Alphaproteobacteria,3N72Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
HKD1_k127_4107469_7	1267005.KB911263_gene1363	1.047e-31	126.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria,3N796@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_4107469_1	1267005.KB911263_gene1362	1.033e-154	501.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,3N681@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD1_k127_4107469_4	1267005.KB911263_gene1361	9.713e-68	234.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,3N6SA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_4107469_9	582899.Hden_2621	5.214e-22	96.0	COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,3N7EN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF465)	MA20_03740	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD1_k127_4107469_10	670307.HYPDE_36688	4.187e-19	88.0	COG5570@1|root,COG5570@2|Bacteria,1NGRE@1224|Proteobacteria,2UJAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD1_k127_4107469_0	582899.Hden_2614	8.513e-292	902.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,3N7ZG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_29420	-	6.2.1.48	ko:K00666,ko:K02182	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_4107469_2	670307.HYPDE_36638	7.022e-107	362.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,3N6PJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1013)	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
HKD1_k127_4107469_5	1267005.KB911256_gene1813	2.145e-67	231.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	-	GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HKD1_k127_4107469_6	1267005.KB911256_gene1814	3.408e-40	152.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,3N6T7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_4109977_30	648757.Rvan_1583	3.88e-34	141.0	COG1605@1|root,COG1605@2|Bacteria,1PV10@1224|Proteobacteria,2V6I1@28211|Alphaproteobacteria,3N78S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Chorismate mutase, type II	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
HKD1_k127_4109977_5	1267005.KB911256_gene2052	5.553e-276	854.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,3N67X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_4109977_29	717785.HYPMC_1134	9.389e-38	143.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,3N76V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_4109977_4	1267005.KB911256_gene2048	9.382e-277	871.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,2TUJQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	MA20_01900	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4109977_23	1267005.KB911256_gene2047	8.576e-61	214.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,3N6VB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_4109977_11	1267005.KB911256_gene2046	9.204e-140	455.0	28X2W@1|root,2ZJ1E@2|Bacteria,1R92Z@1224|Proteobacteria,2TS5H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PcfJ
HKD1_k127_4109977_8	1211115.ALIQ01000076_gene3899	6.192e-177	570.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD1_k127_4109977_10	670307.HYPDE_35173	1.774e-168	533.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,3N6KC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_4109977_6	582899.Hden_0635	1.535e-231	732.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,3N6DW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_4109977_32	187272.Mlg_2272	2.609e-24	105.0	COG1598@1|root,COG1598@2|Bacteria,1NBIX@1224|Proteobacteria,1SCV3@1236|Gammaproteobacteria,1WZ6M@135613|Chromatiales	135613|Chromatiales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_4109977_33	864051.BurJ1DRAFT_1863	3.431e-24	104.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HKD1_k127_4109977_26	1123360.thalar_00345	1.906e-52	193.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2U7BZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD1_k127_4109977_12	1267005.KB911256_gene2043	8.317e-136	443.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,3N6BY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_4109977_1	1267005.KB911260_gene3578	0.0	1417.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,3N651@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HKD1_k127_4109977_3	670307.HYPDE_35208	2.943e-282	886.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,3N6K7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
HKD1_k127_4109977_27	1267005.KB911260_gene3576	1.901e-48	178.0	COG5349@1|root,COG5349@2|Bacteria,1MZDD@1224|Proteobacteria,2UCM4@28211|Alphaproteobacteria,3N74I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HKD1_k127_4109977_31	582899.Hden_0627	6.914e-26	108.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria,3N79H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD1_k127_4109977_7	717785.HYPMC_1121	6.854e-205	646.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,3N676@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
HKD1_k127_4109977_20	1267005.KB911260_gene3572	6.009e-66	227.0	COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,2TVXW@28211|Alphaproteobacteria,3N6RY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_4109977_34	1211115.ALIQ01000204_gene4786	8.989e-20	91.0	2DNWQ@1|root,32ZJY@2|Bacteria,1Q49Z@1224|Proteobacteria,2VASF@28211|Alphaproteobacteria,3NBMC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3572
HKD1_k127_4109977_17	670307.HYPDE_35243	1.319e-84	289.0	29APY@1|root,2ZXPR@2|Bacteria,1R817@1224|Proteobacteria,2TSBC@28211|Alphaproteobacteria,3N8C4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1849)	MA20_36210	-	-	-	-	-	-	-	-	-	-	-	DUF1849
HKD1_k127_4109977_21	1267005.KB911260_gene3568	1.968e-64	224.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,3N75Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD1_k127_4109977_15	717785.HYPMC_1116	1.458e-92	317.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2TV1D@28211|Alphaproteobacteria,3N6ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD1_k127_4109977_9	717785.HYPMC_1115	9.526e-170	543.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,3N61F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD1_k127_4109977_22	1122132.AQYH01000018_gene1137	5.425e-62	216.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,4BDZT@82115|Rhizobiaceae	28211|Alphaproteobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_4109977_19	582899.Hden_0618	3.844e-69	240.0	COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,2U7MU@28211|Alphaproteobacteria,3N98D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD1_k127_4109977_2	582899.Hden_0617	0.0	1362.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,3N627@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_4109977_24	1267005.KB911256_gene2017	1.233e-55	199.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,3N6W6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD1_k127_4109977_28	1267005.KB911256_gene2016	8.794e-41	154.0	COG5490@1|root,COG5490@2|Bacteria,1MZW0@1224|Proteobacteria,2UC4T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phasin family	MA20_36110	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_4109977_13	717785.HYPMC_1109	4.942e-106	362.0	COG1686@1|root,COG3266@1|root,COG1686@2|Bacteria,COG3266@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria,3N6PX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11,SPOR
HKD1_k127_4109977_18	1267005.KB911256_gene2013	1.323e-79	271.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,2TT35@28211|Alphaproteobacteria,3N8YH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DnaJ molecular chaperone homology domain	MA20_36100	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_4109977_16	1267005.KB911256_gene2012	2.869e-90	307.0	COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,3N6R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4109977_0	1267005.KB911256_gene2011	0.0	1504.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,3N69V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HKD1_k127_4109977_14	582899.Hden_2346	1.226e-96	329.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,3N6SU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD1_k127_4109977_25	717785.HYPMC_2748	6.991e-55	196.0	COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,2U5EU@28211|Alphaproteobacteria,3N8HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the EutC family	eutC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0009350,GO:0019842,GO:0031419,GO:0032991,GO:0036094,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0097159,GO:1901363,GO:1902494	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
HKD1_k127_412531_3	258594.RPA1995	5.984e-06	53.0	2CKRE@1|root,32SCW@2|Bacteria,1MWRU@1224|Proteobacteria,2TSRM@28211|Alphaproteobacteria,3JQVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2865)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2865
HKD1_k127_412531_0	1267005.KB911257_gene996	7.497e-137	442.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,3N7ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase zinc-binding	MA20_25320	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_412531_1	717785.HYPMC_4570	1.081e-86	291.0	COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,2U76Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	rrna methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
HKD1_k127_412531_2	1267005.KB911257_gene998	4.412e-44	168.0	COG5342@1|root,COG5342@2|Bacteria,1R46Z@1224|Proteobacteria,2VGJG@28211|Alphaproteobacteria,3N9I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	invasion associated locus B	-	-	-	-	-	-	-	-	-	-	-	-	IalB
HKD1_k127_4154107_1	319003.Bra1253DRAFT_05283	1.682e-82	285.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JRAF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_7,dCache_1
HKD1_k127_4154107_3	670307.HYPDE_28778	8.752e-64	228.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N7R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_7
HKD1_k127_4154107_0	187272.Mlg_1923	1.231e-107	362.0	COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,1RXZ2@1236|Gammaproteobacteria,1WWI4@135613|Chromatiales	135613|Chromatiales	E	PFAM ABC transporter	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE_2
HKD1_k127_4154107_2	991905.SL003B_2572	1.329e-73	254.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,4BQHT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD1_k127_4154107_4	745310.G432_16795	1.18e-54	198.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2K17W@204457|Sphingomonadales	204457|Sphingomonadales	P	Molybdenum ABC transporter	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD1_k127_416334_1	1267005.KB911257_gene860	2.549e-19	94.0	2C8HF@1|root,2ZXE6@2|Bacteria,1R5PH@1224|Proteobacteria,2U64K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_43475	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_416334_0	717785.HYPMC_4657	1.25e-199	628.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,3N62E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD1_k127_416334_2	511.JT27_03605	4.003e-16	79.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2VKZ2@28216|Betaproteobacteria,3T1D1@506|Alcaligenaceae	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_4166136_10	582899.Hden_2433	3.202e-15	77.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,3N7AJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD1_k127_4166136_6	1267005.KB911257_gene1099	8.171e-40	149.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N91P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the bacterial histone-like protein family	hupA	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_4166136_8	1267005.KB911255_gene2620	4.277e-18	95.0	2BX5R@1|root,34AVN@2|Bacteria,1P2HF@1224|Proteobacteria,2UVQ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4166136_2	717785.HYPMC_3106	8.63e-115	380.0	COG3000@1|root,COG3000@2|Bacteria,1PK2Y@1224|Proteobacteria,2VATI@28211|Alphaproteobacteria,3N9BM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_4166136_11	639283.Snov_0139	2.217e-06	57.0	2DRQ5@1|root,33CJP@2|Bacteria,1NC87@1224|Proteobacteria,2VG4E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
HKD1_k127_4166136_12	264198.Reut_A0388	3.242e-06	53.0	2EW11@1|root,33PED@2|Bacteria,1NJMS@1224|Proteobacteria,2W1A9@28216|Betaproteobacteria,1K3DP@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4166136_4	717785.HYPMC_3108	1.751e-103	343.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4166136_1	114615.BRADO1412	9.389e-118	394.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2U2UG@28211|Alphaproteobacteria,3JWWV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c
HKD1_k127_4166136_3	1267005.KB911259_gene3880	4.06e-109	356.0	COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,2VEYE@28211|Alphaproteobacteria,3N6RX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_4166136_0	717785.HYPMC_1011	2.279e-118	387.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria,3N6M5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_4166136_5	1267005.KB911259_gene3877	8.535e-61	213.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,3N75U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_4166136_9	670307.HYPDE_35713	4.603e-16	83.0	COG3170@1|root,COG3170@2|Bacteria,1QW53@1224|Proteobacteria,2U4DN@28211|Alphaproteobacteria,3N9IN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	TIGRFAM protein TolA	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
HKD1_k127_4183458_0	1267005.KB911256_gene1656	0.0	1047.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,3N64P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_4183458_4	717785.HYPMC_3762	4.06e-69	240.0	COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,2UCGN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD1_k127_4183458_3	582899.Hden_0484	2.067e-110	364.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	(Lipo)protein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD1_k127_4183458_2	717785.HYPMC_3764	7.458e-131	429.0	COG1215@1|root,COG1215@2|Bacteria,1Q6U2@1224|Proteobacteria,2VG3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Hopanoid biosynthesis associated glycosyl transferase protein HpnI	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HKD1_k127_4183458_1	460265.Mnod_7154	6.177e-259	804.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TRFJ@28211|Alphaproteobacteria,1JS0K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_4194858_0	1267005.KB911256_gene1833	0.0	1018.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,3N680@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
HKD1_k127_4194858_1	1267005.KB911256_gene1832	7.824e-243	754.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,3N6GF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_4194858_2	1267005.KB911256_gene1831	1.129e-93	310.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,3N6N8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
HKD1_k127_4218944_30	582899.Hden_0058	3.225e-24	102.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_4218944_8	243233.MCA0318	1.306e-93	321.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XERF@135618|Methylococcales	135618|Methylococcales	C	PFAM Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD1_k127_4218944_35	1267005.KB911255_gene2706	1.558e-10	63.0	COG0457@1|root,COG0457@2|Bacteria,1R5C2@1224|Proteobacteria,2UBAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_17,TPR_19
HKD1_k127_4218944_33	1267005.KB911255_gene2706	1.931e-12	72.0	COG0457@1|root,COG0457@2|Bacteria,1R5C2@1224|Proteobacteria,2UBAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_17,TPR_19
HKD1_k127_4218944_34	323848.Nmul_A0120	1.187e-11	66.0	COG3950@1|root,COG3950@2|Bacteria,1MUE0@1224|Proteobacteria,2VX0H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21,AAA_23
HKD1_k127_4218944_10	1132855.KB913035_gene1741	1.145e-84	294.0	COG3950@1|root,COG3950@2|Bacteria,1PHP4@1224|Proteobacteria,2WB2C@28216|Betaproteobacteria,2KP0W@206350|Nitrosomonadales	206350|Nitrosomonadales	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
HKD1_k127_4218944_23	1132855.KB913035_gene1740	3.793e-37	148.0	COG1403@1|root,COG1403@2|Bacteria,1N3X9@1224|Proteobacteria,2VY11@28216|Betaproteobacteria	28216|Betaproteobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HKD1_k127_4218944_18	497964.CfE428DRAFT_2925	4.653e-47	171.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_4218944_22	1380394.JADL01000029_gene4416	2.2e-39	157.0	293J8@1|root,2ZR19@2|Bacteria,1R6Y4@1224|Proteobacteria,2U57A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4218944_24	1267005.KB911259_gene3850	3.598e-35	136.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2UC5C@28211|Alphaproteobacteria,3N90Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	MA20_01405	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HKD1_k127_4218944_11	670307.HYPDE_31098	2.006e-84	283.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2U5K0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_4218944_19	159450.NH14_07855	2.347e-44	169.0	COG4319@1|root,COG4319@2|Bacteria,1RII1@1224|Proteobacteria,2VXCZ@28216|Betaproteobacteria,1K8QB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_4218944_7	670307.HYPDE_41793	7.76e-96	330.0	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,3N8DB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD1_k127_4218944_29	670307.HYPDE_41788	2.657e-28	119.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,2UFK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD1_k127_4218944_20	1541065.JRFE01000014_gene1178	5.089e-42	155.0	COG5207@1|root,COG5207@2|Bacteria,1G7WG@1117|Cyanobacteria	1117|Cyanobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HKD1_k127_4218944_2	93220.LV28_10780	2.433e-155	498.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1K0MK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Nadh flavin oxidoreductase nadh oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD1_k127_4218944_28	1267005.KB911259_gene3854	1.443e-29	126.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	CP_0328	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4218944_4	1267005.KB911256_gene1914	1.641e-126	422.0	COG1196@1|root,COG1196@2|Bacteria,1QW5B@1224|Proteobacteria,2TWN5@28211|Alphaproteobacteria,3N7CD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4218944_9	717785.HYPMC_3168	1.239e-88	301.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,3N6YS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1134
HKD1_k127_4218944_14	1267005.KB911256_gene1912	3.549e-72	254.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria,3N8EE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD1_k127_4218944_6	1267005.KB911256_gene1911	1.459e-98	327.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria,3N71W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Histidine phosphotransferase C-terminal domain	MA20_46320	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
HKD1_k127_4218944_27	1267005.KB911256_gene1909	8.087e-30	123.0	COG1136@1|root,COG1136@2|Bacteria,1RH0D@1224|Proteobacteria,2TQV1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_4218944_31	1267005.KB911256_gene1909	4.02e-24	112.0	COG1136@1|root,COG1136@2|Bacteria,1RH0D@1224|Proteobacteria,2TQV1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_4218944_13	1267005.KB911256_gene1908	1.942e-74	261.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,2U1K9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
HKD1_k127_4218944_25	582899.Hden_0862	5.717e-35	134.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3N932@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Cold shock	MA20_05565	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_4218944_5	1267005.KB911256_gene1905	2.413e-110	364.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,3N6TM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HKD1_k127_4218944_16	670307.HYPDE_27793	2.362e-65	226.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,3N6ZN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD1_k127_4218944_0	1267005.KB911255_gene2401	1.844e-207	655.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,3N68H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_4218944_1	1267005.KB911255_gene2404	1.164e-176	565.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,3N89M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD1_k127_4218944_17	670307.HYPDE_27773	9.861e-60	215.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2UCFZ@28211|Alphaproteobacteria,3N73K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HKD1_k127_4218944_3	670307.HYPDE_27768	2.403e-140	452.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,3N6C1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD1_k127_4218944_12	1267005.KB911255_gene2407	4.498e-75	275.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_4218944_21	1177928.TH2_07706	8.737e-40	156.0	COG2258@1|root,COG2258@2|Bacteria,1PVVH@1224|Proteobacteria,2UNAM@28211|Alphaproteobacteria,2JYAB@204441|Rhodospirillales	204441|Rhodospirillales	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD1_k127_4218944_15	717785.HYPMC_3186	7.364e-67	232.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2TQWY@28211|Alphaproteobacteria,3N90W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
HKD1_k127_4264558_4	582899.Hden_0392	9.926e-145	466.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,3N6GD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
HKD1_k127_4264558_9	1267005.KB911255_gene2469	1.291e-94	317.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,3N6WM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	glutathione S-transferase	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
HKD1_k127_4264558_7	717785.HYPMC_0376	7.966e-111	364.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,3N6R7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_4264558_10	1267005.KB911255_gene2471	2.033e-54	196.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,3N71H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD1_k127_4264558_1	1267005.KB911255_gene2472	1.081e-216	683.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,3N637@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_4264558_6	1267005.KB911255_gene2473	3.019e-132	429.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,3N61R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4264558_5	1267005.KB911255_gene2474	3.695e-141	472.0	COG1934@1|root,COG5375@1|root,COG1934@2|Bacteria,COG5375@2|Bacteria,1Q8G1@1224|Proteobacteria,2VEP1@28211|Alphaproteobacteria,3N9AZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
HKD1_k127_4264558_8	717785.HYPMC_0382	8.62e-100	329.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,3N6PC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	3'-5' exonuclease	rnd1	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
HKD1_k127_4264558_2	717785.HYPMC_3815	1.335e-203	642.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,3N890@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cysteine-rich domain	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
HKD1_k127_4264558_3	1267005.KB911255_gene2628	2.105e-166	533.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,3N7K6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidase	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_4264558_0	1267005.KB911255_gene2627	2.523e-225	707.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,3N7KG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_4264558_11	1120983.KB894571_gene2491	1.719e-40	155.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,1JP23@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	ttdR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4270125_1	717785.HYPMC_2198	2.713e-160	517.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TT55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfide dehydrogenase	fccB	-	1.8.2.3,1.8.5.4	ko:K17218,ko:K17229	ko00920,ko01120,map00920,map01120	-	R09499,R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2
HKD1_k127_4270125_4	1238182.C882_2045	1.48e-29	123.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria,2JTAQ@204441|Rhodospirillales	204441|Rhodospirillales	S	sulfur oxidation protein (SoxY)	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HKD1_k127_4270125_3	717785.HYPMC_2201	4.953e-35	140.0	COG5501@1|root,COG5501@2|Bacteria,1N03V@1224|Proteobacteria,2TWQY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidation protein (SoxZ)	MA20_17515	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HKD1_k127_4270125_2	670307.HYPDE_33413	1.878e-56	207.0	2DMT2@1|root,32TGY@2|Bacteria,1R3E1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4270125_0	1267005.KB911258_gene165	1.531e-294	916.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,3N62B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ABC transporter	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_4277034_6	670307.HYPDE_35348	6.491e-112	371.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,3N6Z9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_4277034_3	1121028.ARQE01000002_gene1754	2.476e-176	562.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,2PJ4S@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	Beta-eliminating lyase	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_4277034_10	1267005.KB911256_gene1975	1.541e-48	177.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,3N716@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	FeS assembly SUF system protein	MA20_30700	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD1_k127_4277034_8	582899.Hden_2352	4.144e-50	181.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,3N748@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD1_k127_4277034_9	1547437.LL06_05620	7.459e-49	183.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,43JSE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HKD1_k127_4277034_12	1380394.JADL01000024_gene93	7.609e-27	119.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2V15Q@28211|Alphaproteobacteria,2JU5Z@204441|Rhodospirillales	204441|Rhodospirillales	K	TfoX N-terminal domain	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
HKD1_k127_4277034_2	717785.HYPMC_1102	5.05e-224	704.0	COG0513@1|root,COG3087@1|root,COG0513@2|Bacteria,COG3087@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,3N66Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_4277034_7	582899.Hden_2349	4.14e-71	249.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2TRGG@28211|Alphaproteobacteria,3N8GU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_4277034_5	582899.Hden_2348	1.174e-162	524.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD1_k127_4277034_0	1040982.AXAL01000007_gene2840	2.075e-307	955.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,43H9B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_4277034_4	1054213.HMPREF9946_03764	2.615e-168	538.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,2JQSE@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4277034_1	717785.HYPMC_2749	3.755e-235	734.0	COG4303@1|root,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,2TTNA@28211|Alphaproteobacteria,3N84Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Ethanolamine ammonia lyase large subunit (EutB)	MA20_16105	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
HKD1_k127_4277034_11	717785.HYPMC_2748	1.991e-41	159.0	COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,2U5EU@28211|Alphaproteobacteria,3N8HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the EutC family	eutC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0009350,GO:0019842,GO:0031419,GO:0032991,GO:0036094,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0097159,GO:1901363,GO:1902494	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
HKD1_k127_4282057_1	670307.HYPDE_38923	1.01e-134	436.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2TSNS@28211|Alphaproteobacteria,3N7XX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	prmB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
HKD1_k127_4282057_0	1267005.KB911259_gene3930	1.65e-166	534.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,3N67T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_4282057_2	717785.HYPMC_1881	9.595e-124	417.0	COG1376@1|root,COG3064@1|root,COG1376@2|Bacteria,COG3064@2|Bacteria,1MX14@1224|Proteobacteria,2TS68@28211|Alphaproteobacteria,3N7JW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4299917_16	56780.SYN_03169	2.293e-09	63.0	COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,42U32@68525|delta/epsilon subdivisions,2WSHT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4299917_0	717785.HYPMC_2877	0.0	1603.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3N673@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_4299917_9	717785.HYPMC_2878	1.911e-92	312.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,3N6MP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD1_k127_4299917_5	582899.Hden_1923	5.668e-198	624.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,3N6BX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_4299917_2	670307.HYPDE_28933	9.622e-296	916.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3N7Q2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_4299917_14	911045.PSE_3420	7.083e-18	88.0	COG5454@1|root,COG5454@2|Bacteria,1N6T0@1224|Proteobacteria,2UF4C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1467)	MA20_37275	-	-	-	-	-	-	-	-	-	-	-	DUF1467
HKD1_k127_4299917_11	1267005.KB911256_gene1844	1.325e-72	246.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria,3N6WS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_4299917_3	1267005.KB911256_gene1843	8.18e-253	791.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,3N65C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zn-dependent metallo-hydrolase RNA specificity domain	rnjA	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD1_k127_4299917_12	1267005.KB911256_gene1842	4.073e-70	261.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,3N70S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
HKD1_k127_4299917_7	1267005.KB911256_gene1840	1.159e-173	561.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,3N6I1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_4299917_4	670307.HYPDE_28903	6.007e-235	743.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,3N6M4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-quinone oxidoreductase chain	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD1_k127_4299917_1	670307.HYPDE_28898	5.922e-307	953.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,3N6EE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CP	NADH-quinone oxidoreductase chain L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
HKD1_k127_4299917_13	670307.HYPDE_28893	4.114e-45	167.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,3N75V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_4299917_10	1267005.KB911256_gene1836	3.938e-76	261.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,3N6QS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_4299917_8	1267005.KB911256_gene1835	8.931e-93	306.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,3N6JA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K00338,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4
HKD1_k127_4299917_6	670307.HYPDE_28878	4.867e-180	568.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,3N6J3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_4299917_15	670292.JH26_18350	4.15e-11	64.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,1JRGX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM NADH-quinone oxidoreductase, chain G	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
HKD1_k127_4368609_9	1267005.KB911258_gene110	7.913e-15	76.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,2TU31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
HKD1_k127_4368609_0	670307.HYPDE_28968	1.723e-191	601.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,3N699@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_4368609_4	582899.Hden_1917	1.385e-118	388.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,3N6FT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_4368609_5	1267005.KB911258_gene106	1.987e-110	362.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,3N6PN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_4368609_7	1267005.KB911258_gene105	3.048e-86	289.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,3N6SC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_4368609_6	1267005.KB911258_gene104	2.492e-110	362.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,3N6N1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_4368609_8	1267005.KB911258_gene103	5.713e-71	253.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2U9ED@28211|Alphaproteobacteria,3N75T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_4368609_2	717785.HYPMC_2866	1.253e-152	494.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,3N82P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_4368609_3	582899.Hden_1911	7.675e-144	466.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,3N6AS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD1_k127_4368609_1	717785.HYPMC_2864	3.989e-184	585.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,3N6CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_4424132_2	717785.HYPMC_0061	2.33e-86	289.0	COG0433@1|root,COG1484@1|root,COG0433@2|Bacteria,COG1484@2|Bacteria,1P0I3@1224|Proteobacteria,2U0J8@28211|Alphaproteobacteria,3N9D3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF853,DUF87
HKD1_k127_4424132_3	1267005.KB911257_gene684	4.453e-79	278.0	2B8YC@1|root,3228V@2|Bacteria,1N5W1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4424132_1	670307.HYPDE_22793	5.816e-91	305.0	COG2340@1|root,COG2340@2|Bacteria,1MZ84@1224|Proteobacteria,2UFSP@28211|Alphaproteobacteria,3N7C8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cysteine-rich secretory protein family	MA20_18185	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_4424132_0	582899.Hden_0051	4.114e-164	528.0	COG2244@1|root,COG2244@2|Bacteria,1MWKV@1224|Proteobacteria,2TTYS@28211|Alphaproteobacteria,3N90H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Polysaccharide biosynthesis protein	MA20_18165	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_4424132_5	717785.HYPMC_0066	1.514e-07	57.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TT24@28211|Alphaproteobacteria,3N6R4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacA3	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11
HKD1_k127_4436609_0	1267005.KB911257_gene683	0.0	1432.0	COG0433@1|root,COG1484@1|root,COG0433@2|Bacteria,COG1484@2|Bacteria,1P0I3@1224|Proteobacteria,2U0J8@28211|Alphaproteobacteria,3N9D3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF853,DUF87
HKD1_k127_4436609_1	1267005.KB911257_gene682	0.0	1097.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD1_k127_4436609_3	582899.Hden_0046	6.715e-223	721.0	2CYKW@1|root,32T4E@2|Bacteria,1N3JA@1224|Proteobacteria,2UEZF@28211|Alphaproteobacteria,3N7PP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4436609_2	1267005.KB911257_gene1077	1.757e-269	846.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
HKD1_k127_446683_13	717785.HYPMC_4599	7.464e-19	88.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,3N77Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_446683_0	582899.Hden_3238	0.0	1104.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,3N6AQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_446683_4	582899.Hden_2200	6.285e-93	313.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2TQRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_446683_5	658187.LDG_8722	6.743e-89	305.0	COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,1RTIR@1236|Gammaproteobacteria,1JEIF@118969|Legionellales	118969|Legionellales	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
HKD1_k127_446683_3	876269.ARWA01000001_gene2667	1.722e-120	402.0	COG3850@1|root,COG4585@1|root,COG3850@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2TSY5@28211|Alphaproteobacteria,3NC6P@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
HKD1_k127_446683_7	876269.ARWA01000001_gene2666	1.338e-77	264.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria,3NCDZ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_446683_12	717785.HYPMC_1053	1.332e-20	94.0	2968C@1|root,2ZTID@2|Bacteria,1P7TY@1224|Proteobacteria,2UWB4@28211|Alphaproteobacteria,3N97P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_446683_11	453591.Igni_0915	3.446e-34	136.0	COG1051@1|root,arCOG01075@2157|Archaea,2XR8E@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM NUDIX hydrolase	-	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_446683_1	1267005.KB911257_gene1086	5.13e-157	498.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,3N6IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
HKD1_k127_446683_9	717785.HYPMC_4604	5.809e-60	213.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,2UAPG@28211|Alphaproteobacteria,3N763@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_43515	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_446683_8	1267005.KB911257_gene1089	5.879e-77	266.0	COG1670@1|root,COG1670@2|Bacteria,1QVE8@1224|Proteobacteria,2TWDB@28211|Alphaproteobacteria,3N8KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_446683_2	582899.Hden_3232	9.018e-136	456.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,3N61Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	AFG1-like ATPase	zapE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HKD1_k127_446683_14	1267005.KB911261_gene2320	8.274e-19	89.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,2UAH9@28211|Alphaproteobacteria,3N8UV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD1_k127_448156_0	670307.HYPDE_29763	2.664e-232	724.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_448156_2	1040983.AXAE01000027_gene5171	1.991e-90	309.0	COG1752@1|root,COG1752@2|Bacteria,1MX8Y@1224|Proteobacteria,2TVP9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_448156_3	446470.Snas_6294	1.439e-79	280.0	COG1680@1|root,COG1680@2|Bacteria,2I9GC@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_448156_4	1298867.AUES01000065_gene2444	2.131e-65	240.0	COG3203@1|root,COG3203@2|Bacteria,1Q96Q@1224|Proteobacteria,2U9II@28211|Alphaproteobacteria,3K2DE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	outer membrane porin, OprD family	-	-	-	-	-	-	-	-	-	-	-	-	OprD
HKD1_k127_448156_1	1267005.KB911257_gene747	2.929e-131	429.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,3N6IH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase S33 family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_448156_5	670307.HYPDE_29203	1.312e-35	139.0	COG2010@1|root,COG2010@2|Bacteria,1RCYF@1224|Proteobacteria,2U833@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_4499604_7	648757.Rvan_1583	5.589e-39	149.0	COG1605@1|root,COG1605@2|Bacteria,1PV10@1224|Proteobacteria,2V6I1@28211|Alphaproteobacteria,3N78S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Chorismate mutase, type II	-	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
HKD1_k127_4499604_9	582899.Hden_2789	5.579e-27	116.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4499604_1	1267005.KB911256_gene2055	8.092e-273	845.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,3N6H4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_4499604_12	717785.HYPMC_4014	4.521e-22	100.0	2DD4B@1|root,2ZGFG@2|Bacteria,1P4T4@1224|Proteobacteria,2UYND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4499604_2	1267005.KB911261_gene2255	2.76e-98	328.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,3N6U1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD1_k127_4499604_10	670307.HYPDE_25673	8.377e-27	113.0	COG2010@1|root,COG2010@2|Bacteria,1NPVI@1224|Proteobacteria,2UN8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4499604_11	204773.HEAR2369	1.089e-22	99.0	COG3360@1|root,COG3360@2|Bacteria,1PURR@1224|Proteobacteria,2WAWD@28216|Betaproteobacteria,4784E@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_4499604_6	981384.AEYW01000006_gene2251	3.423e-64	229.0	COG2267@1|root,COG2267@2|Bacteria,1QTNZ@1224|Proteobacteria,2V255@28211|Alphaproteobacteria,4ND6G@97050|Ruegeria	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_4499604_0	1267005.KB911259_gene3818	4.249e-273	861.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,3N7VX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD1_k127_4499604_4	1267005.KB911259_gene3819	3.027e-76	278.0	COG3712@1|root,COG3712@2|Bacteria,1QW4T@1224|Proteobacteria,2TWMQ@28211|Alphaproteobacteria,3N97T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,OMP_b-brl
HKD1_k127_4499604_3	717785.HYPMC_4442	3.001e-76	260.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome b561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB,YceI
HKD1_k127_4499604_5	670307.HYPDE_39173	7.793e-70	250.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,3N988@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_4499604_13	1123366.TH3_08112	5.36e-07	60.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TRUC@28211|Alphaproteobacteria,2JQP6@204441|Rhodospirillales	204441|Rhodospirillales	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD1_k127_4518890_3	1415754.JQMK01000012_gene1003	2.58e-46	175.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,1S5DH@1236|Gammaproteobacteria,46DMM@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HKD1_k127_4518890_2	113395.AXAI01000032_gene710	6.119e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria,3JT5X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4518890_1	1267005.KB911255_gene2397	9.113e-105	352.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria,3N6T8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pyrimidine 5'-nucleotidase	MA20_21845	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD1_k127_4518890_0	582899.Hden_3419	9.849e-152	484.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,3N62P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_4518890_4	1267005.KB911255_gene2395	1.186e-07	53.0	COG0542@1|root,COG0542@2|Bacteria,1NXPQ@1224|Proteobacteria,2UTUZ@28211|Alphaproteobacteria,3N8QT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	-	-	-	-	-	-	-	-	-	Clp_N
HKD1_k127_4530111_0	1267005.KB911256_gene1950	5.381e-94	322.0	COG2845@1|root,COG2845@2|Bacteria,1R4X7@1224|Proteobacteria,2U5AU@28211|Alphaproteobacteria,3N771@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
HKD1_k127_4530111_2	402881.Plav_0582	2.497e-64	229.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synt_N,Spermine_synth
HKD1_k127_4530111_1	717785.HYPMC_4047	8.624e-88	301.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,3N8US@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD1_k127_4584138_5	1267005.KB911262_gene3316	2.569e-36	143.0	COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,2UGDT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_4584138_0	1525715.IX54_16065	0.0	1159.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,2PW6V@265|Paracoccus	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_4584138_1	318586.Pden_4290	6.306e-110	377.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2PUH0@265|Paracoccus	28211|Alphaproteobacteria	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
HKD1_k127_4584138_7	1123072.AUDH01000024_gene336	6.312e-15	87.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2TT91@28211|Alphaproteobacteria,2JTBE@204441|Rhodospirillales	204441|Rhodospirillales	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
HKD1_k127_4584138_3	1267005.KB911262_gene3317	2.155e-88	304.0	COG1376@1|root,COG1376@2|Bacteria,1NHM3@1224|Proteobacteria,2UHVV@28211|Alphaproteobacteria,3N8IS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4584138_2	1267005.KB911262_gene3318	6.66e-107	356.0	COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,3N6GS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	periplasmic solute binding protein	znuA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_4584138_4	1267005.KB911262_gene3319	2.76e-66	235.0	COG3683@1|root,COG3683@2|Bacteria,1R4QA@1224|Proteobacteria,2VGNV@28211|Alphaproteobacteria,3N70H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1007)	MA20_06510	-	-	-	-	-	-	-	-	-	-	-	DUF1007
HKD1_k127_4584138_6	717785.HYPMC_0584	8.498e-22	99.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7
HKD1_k127_4585636_4	1040989.AWZU01000051_gene1009	3.827e-09	60.0	2AFMZ@1|root,315PD@2|Bacteria,1NE9J@1224|Proteobacteria,2UGMH@28211|Alphaproteobacteria,3K19D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4585636_2	1267005.KB911259_gene3788	1.44e-52	193.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_4585636_3	1267005.KB911261_gene2311	5.532e-21	105.0	COG1873@1|root,COG1873@2|Bacteria,1N6X0@1224|Proteobacteria,2UFAR@28211|Alphaproteobacteria,3N9H0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_4585636_0	1267005.KB911257_gene858	2.199e-206	655.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,3N66F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4585636_1	864069.MicloDRAFT_00013840	3.814e-84	285.0	COG0583@1|root,COG0583@2|Bacteria,1R51E@1224|Proteobacteria,2TZIK@28211|Alphaproteobacteria,1JXVG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4606242_2	1267005.KB911255_gene2540	2.101e-08	55.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,3N69J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_4606242_0	582899.Hden_2259	1.332e-283	880.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3N6GM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
HKD1_k127_4636540_8	1267005.KB911255_gene2704	4.647e-72	260.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2UF9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1525 Micrococcal nuclease (thermonuclease) homologs	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD1_k127_4636540_2	1267005.KB911256_gene1530	2.942e-152	492.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,3N6KX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	oxidase, subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HKD1_k127_4636540_1	1267005.KB911256_gene1531	3.965e-241	752.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,3N6SM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD1_k127_4636540_0	1267005.KB911255_gene2707	8.017e-284	896.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4189,PG_binding_1,Pkinase,WD40
HKD1_k127_4636540_9	1267005.KB911255_gene2708	5.091e-39	155.0	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,2UM3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA
HKD1_k127_4636540_6	1267005.KB911255_gene2709	9.649e-79	271.0	COG1716@1|root,COG1716@2|Bacteria,1RHU9@1224|Proteobacteria,2UBJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD1_k127_4636540_5	1267005.KB911255_gene2710	3.984e-98	340.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD1_k127_4636540_7	1094980.Mpsy_1431	3.633e-72	261.0	COG3177@1|root,arCOG03111@2157|Archaea,2Y8I0@28890|Euryarchaeota,2NA98@224756|Methanomicrobia	224756|Methanomicrobia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_DeoR
HKD1_k127_4636540_3	582899.Hden_3212	2.247e-146	474.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,3N6CH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Mg chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_4636540_12	1298858.AUEL01000009_gene4184	2.069e-24	107.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,2TX9R@28211|Alphaproteobacteria,43RUH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4636540_4	717785.HYPMC_4499	1.54e-132	430.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,3N6BF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_4636540_11	582899.Hden_3210	1.173e-24	113.0	COG1872@1|root,COG1872@2|Bacteria,1N6V2@1224|Proteobacteria,2UF67@28211|Alphaproteobacteria,3N7ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0235 family	MA20_25230	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_4636540_10	670307.HYPDE_39363	9.457e-31	127.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,3N7BT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	YGGT family	MA20_25225	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD1_k127_4661504_0	670307.HYPDE_23958	5.6e-196	612.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3N86Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_4661504_1	670307.HYPDE_23348	1.781e-51	185.0	COG4772@1|root,COG4772@2|Bacteria,1MXJU@1224|Proteobacteria,2TRYT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD1_k127_4703075_3	1429916.X566_02705	2.043e-101	333.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,3JU27@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter	hndI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4703075_2	666685.R2APBS1_2465	5.094e-132	426.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X3BP@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_4703075_5	1267005.KB911256_gene1452	6.036e-66	246.0	COG0515@1|root,COG0515@2|Bacteria,1NYMK@1224|Proteobacteria,2UTB3@28211|Alphaproteobacteria,3N8TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4703075_0	1267005.KB911256_gene1454	2.058e-190	601.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,3N6AY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_4703075_6	622637.KE124774_gene1578	1.037e-12	70.0	2EJ3S@1|root,33CV1@2|Bacteria,1PUNS@1224|Proteobacteria,2V68J@28211|Alphaproteobacteria,3714J@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4703075_4	1267005.KB911256_gene1438	1.167e-91	306.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2U1NG@28211|Alphaproteobacteria,3N9AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD1_k127_4703075_1	1267005.KB911256_gene1439	1.895e-180	571.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,3N7PU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD1_k127_473790_7	1082933.MEA186_26486	6.651e-36	139.0	COG0583@1|root,COG0583@2|Bacteria,1R51E@1224|Proteobacteria,2TZIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_473790_0	717785.HYPMC_2949	5.522e-192	609.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2TQY2@28211|Alphaproteobacteria,3N67S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_473790_6	582899.Hden_1971	1.477e-67	235.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,3N74J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD1_k127_473790_1	670307.HYPDE_28668	1.212e-149	479.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,3N65Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_473790_8	717785.HYPMC_2851	9.319e-33	131.0	COG4520@1|root,COG4520@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_473790_4	438753.AZC_1197	8.368e-83	280.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,3EXXX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD1_k127_473790_5	1267005.KB911263_gene1332	9.668e-69	244.0	COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,2U0NZ@28211|Alphaproteobacteria,3N77D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1499)	MA20_07395	-	-	-	-	-	-	-	-	-	-	-	DUF1499
HKD1_k127_473790_3	670307.HYPDE_29098	1.904e-107	359.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,3N6RE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_473790_10	1297570.MESS4_510155	2.231e-06	52.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_473790_2	297246.lpp2312	7.6e-129	419.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria,1JDB3@118969|Legionellales	118969|Legionellales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_480860_0	1267005.KB911260_gene3531	0.0	1469.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3N6JX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_480860_1	582899.Hden_2179	6.201e-06	51.0	COG1873@1|root,COG1873@2|Bacteria,1R12Z@1224|Proteobacteria,2TYX2@28211|Alphaproteobacteria,3N98V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_4821029_1	395963.Bind_2356	4.244e-123	401.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,3NAAK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N,GST_N_3
HKD1_k127_4821029_2	926562.Oweho_0732	7.517e-90	322.0	COG1409@1|root,COG1409@2|Bacteria,4NHXB@976|Bacteroidetes,1I958@117743|Flavobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_4821029_0	1267005.KB911257_gene709	5.985e-150	501.0	COG2303@1|root,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,2U7D4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EI	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD1_k127_4821029_3	1120999.JONM01000011_gene1626	1.378e-49	185.0	COG2267@1|root,COG2303@1|root,COG2267@2|Bacteria,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,2VH9Z@28216|Betaproteobacteria,2KU00@206351|Neisseriales	206351|Neisseriales	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD1_k127_485132_1	316057.RPD_2809	9.891e-116	381.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,3JRK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_485132_0	1429916.X566_21335	1.111e-190	607.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,3JQYJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
HKD1_k127_485132_2	1120792.JAFV01000001_gene989	1.068e-61	215.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,36XCA@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_48979_3	460265.Mnod_3292	7.957e-109	358.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,2VGDJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD1_k127_48979_2	1304877.KI519399_gene6062	5.73e-111	372.0	COG2187@1|root,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_48979_1	639283.Snov_1191	2.772e-142	472.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,3EYA1@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prsA	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD1_k127_48979_5	504832.OCAR_7118	9.23e-67	243.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria,3JR4B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD1_k127_48979_0	187272.Mlg_1734	3.978e-143	465.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,1RSI9@1236|Gammaproteobacteria,1X00S@135613|Chromatiales	135613|Chromatiales	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD1_k127_48979_4	991905.SL003B_2628	1.218e-77	266.0	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2U5QZ@28211|Alphaproteobacteria,4BS61@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD1_k127_48979_6	991905.SL003B_2629	2.767e-65	230.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,4BS0C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
HKD1_k127_5028346_10	1267005.KB911255_gene2646	5.093e-46	176.0	COG2207@1|root,COG2207@2|Bacteria,1QUXX@1224|Proteobacteria,2U3YA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AraC-binding-like domain	MA20_34385	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HKD1_k127_5028346_6	670307.HYPDE_34178	1.314e-88	296.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria,3N6N3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	MA20_36560	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_5028346_13	717785.HYPMC_0350	3.039e-12	79.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DUF4388,DnaJ
HKD1_k127_5028346_9	438753.AZC_4462	1.187e-60	218.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,3EZBY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HKD1_k127_5028346_12	316055.RPE_1792	1.355e-15	91.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2TUGX@28211|Alphaproteobacteria,3JTJQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OmpA
HKD1_k127_5028346_2	1267005.KB911255_gene2997	1.8e-182	579.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,3N66B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD1_k127_5028346_4	1267005.KB911255_gene2996	8.904e-125	406.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,3N6TF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DnaJ C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
HKD1_k127_5028346_1	1267005.KB911255_gene2995	3.509e-236	740.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,3N6IU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD1_k127_5028346_0	1267005.KB911255_gene2994	0.0	1172.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,3N6DR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_5028346_8	1267005.KB911255_gene2993	6.428e-75	264.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,3N74G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the DnaA family	hda	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
HKD1_k127_5028346_3	1267005.KB911255_gene2992	3.27e-136	449.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,3N6QI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	perM	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
HKD1_k127_5028346_7	1267005.KB911255_gene2991	2.35e-81	274.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	MA20_28295	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_5028346_5	1267005.KB911255_gene2990	2.6e-101	342.0	COG3249@1|root,COG3249@2|Bacteria,1RE2R@1224|Proteobacteria,2U7HJ@28211|Alphaproteobacteria,3N8NS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2066)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2066
HKD1_k127_5028346_11	1411123.JQNH01000001_gene1591	3.328e-23	103.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_5042821_8	582899.Hden_3251	8.566e-17	81.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,3N6WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD1_k127_5042821_5	717785.HYPMC_4588	6.962e-107	355.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,3N6MK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD1_k127_5042821_9	582899.Hden_3248	1.094e-12	68.0	2EIRC@1|root,33CGS@2|Bacteria,1NGFG@1224|Proteobacteria,2UJFR@28211|Alphaproteobacteria,3N7GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
HKD1_k127_5042821_6	1267005.KB911257_gene935	7.265e-78	266.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,3N6ZX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Periplasmic protein thiol disulfide oxidoreductase	ccmG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_5042821_4	1267005.KB911257_gene936	1.267e-112	366.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,3N9HQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_5042821_0	1267005.KB911257_gene937	6.26e-235	736.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2,Sulfate_transp
HKD1_k127_5042821_2	1267005.KB911257_gene938	1.12e-153	494.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
HKD1_k127_5042821_7	648757.Rvan_2179	2.565e-64	231.0	COG2240@1|root,COG2240@2|Bacteria,1MVC9@1224|Proteobacteria,2U2CH@28211|Alphaproteobacteria,3N8GA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	pdxK	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_5042821_3	1267005.KB911257_gene940	3.03e-140	456.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,3N72Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the HpcH HpaI aldolase family	citE	-	3.1.2.30,4.1.3.34	ko:K01644,ko:K14451	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R10612	RC00004,RC00014,RC00067,RC01118	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_5042821_1	717785.HYPMC_4595	3.992e-185	582.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,3N7GP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	MaoC like domain	mch	GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD1_k127_5051034_1	717785.HYPMC_1906	1.478e-85	299.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2TS9S@28211|Alphaproteobacteria,3N7E4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD1_k127_5051034_2	266835.14026248	1.269e-75	257.0	COG3467@1|root,COG3467@2|Bacteria,1RAZD@1224|Proteobacteria,2TXIF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_5051034_3	62928.azo0191	3.825e-62	217.0	COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2VRWK@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	maoC	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_5051034_5	1120948.KB903227_gene4831	5.891e-14	75.0	29SM0@1|root,30DSB@2|Bacteria,2GN13@201174|Actinobacteria,4E0US@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_5052008_3	1120792.JAFV01000001_gene137	3.815e-16	79.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,36XJ4@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD1_k127_5052008_0	717785.HYPMC_0504	1.445e-96	321.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VEVS@28211|Alphaproteobacteria,3N8KM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5082970_2	309807.SRU_0868	3.537e-30	122.0	COG0614@1|root,COG0614@2|Bacteria,4NKCD@976|Bacteroidetes,1FJ5J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_5082970_1	717785.HYPMC_2910	2.125e-49	194.0	COG1570@1|root,COG1570@2|Bacteria,1QW7S@1224|Proteobacteria,2TRHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	LTXXQ motif family protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
HKD1_k127_5082970_0	1032480.MLP_36400	4.03e-55	211.0	COG0105@1|root,COG0105@2|Bacteria,2H7CM@201174|Actinobacteria	201174|Actinobacteria	F	UTP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5082970_3	717785.HYPMC_0100	5.157e-17	80.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,3N6XV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	PFAM acyl-CoA dehydrogenase	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_5110444_0	395964.KE386496_gene3081	2.74e-186	587.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3NA59@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	MA20_01135	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5110444_1	395964.KE386496_gene3080	7.979e-149	481.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TU0W@28211|Alphaproteobacteria,3NA54@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_5110444_8	1280954.HPO_15478	1.501e-09	65.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43ZJT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Peptidase_M10_C
HKD1_k127_5110444_5	582899.Hden_3157	2.837e-74	263.0	COG1525@1|root,COG1525@2|Bacteria,1R3VA@1224|Proteobacteria,2U0NK@28211|Alphaproteobacteria,3N73J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD1_k127_5110444_2	1267005.KB911257_gene952	7.079e-106	353.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,3N6QG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	CarD-like/TRCF domain	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD1_k127_5110444_6	717785.HYPMC_4406	1.965e-64	221.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,3N6Z8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
HKD1_k127_5110444_7	1267005.KB911257_gene954	1.526e-31	135.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,3N78E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	S4 domain	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD1_k127_5110444_3	670307.HYPDE_38983	8.327e-87	299.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,3N66S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
HKD1_k127_5116270_1	717785.HYPMC_3900	1.414e-265	823.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,3N65K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD1_k127_5116270_4	1267005.KB911256_gene1899	2.475e-21	95.0	COG4321@1|root,COG4321@2|Bacteria,1N7Z2@1224|Proteobacteria,2UF7W@28211|Alphaproteobacteria,3N7DG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Ribbon-helix-helix domain	MA20_02235	-	-	-	-	-	-	-	-	-	-	-	RHH_4
HKD1_k127_5116270_2	1267005.KB911256_gene1900	1.808e-259	850.0	COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,3N7AH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	AsmA family	asmA	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD1_k127_5116270_0	1267005.KB911256_gene1901	0.0	1232.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,3N6JN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_5116270_3	977880.RALTA_A1537	1.415e-70	243.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria,1K39I@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_5126782_2	1267005.KB911264_gene3179	1.281e-184	585.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,3N6GZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_5126782_1	670307.HYPDE_32923	6.946e-224	700.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3N68R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_5126782_3	1267005.KB911256_gene1806	1.079e-70	243.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,3N7BE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_5126782_0	1267005.KB911256_gene1807	0.0	1092.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,3N67I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD1_k127_5148329_10	1381123.AYOD01000055_gene516	4.903e-16	80.0	COG1216@1|root,COG1216@2|Bacteria,1N7C8@1224|Proteobacteria,2VGU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5148329_0	1267005.KB911256_gene1850	4.86e-252	788.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,3N62M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD1_k127_5148329_5	1267005.KB911262_gene3309	3.196e-82	279.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,3N6V7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_5148329_2	1267005.KB911262_gene3308	1.386e-150	491.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3N6MU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_5148329_1	1267005.KB911262_gene3307	7.613e-160	514.0	COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,2TRRI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	GfdT protein	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HKD1_k127_5148329_6	648757.Rvan_2589	1.167e-81	295.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,3N9HF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_5148329_3	582899.Hden_3205	6.487e-137	448.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,3N64J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EGP	TIGRFAM drug resistance transporter, Bcr CflA subfamily	MA20_32310	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD1_k127_5148329_7	670307.HYPDE_35603	2.564e-69	248.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TUBN@28211|Alphaproteobacteria,3N736@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_5148329_4	670307.HYPDE_27868	4.957e-113	371.0	COG3315@1|root,COG3315@2|Bacteria,1RG18@1224|Proteobacteria,2VFMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HKD1_k127_5148329_8	648757.Rvan_3531	1.711e-64	224.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,3N6UP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	arsenate reductase	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HKD1_k127_5151863_8	1267005.KB911258_gene454	5.598e-26	106.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,3N6TW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_5151863_0	1267005.KB911258_gene457	4.379e-259	824.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3N6FA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_5151863_4	717785.HYPMC_1739	1.504e-70	250.0	COG2067@1|root,COG2067@2|Bacteria,1MYGU@1224|Proteobacteria,2UB0Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5151863_7	1449065.JMLL01000003_gene2954	3.744e-32	143.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,43NFF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD1_k127_5151863_6	1249627.D779_4053	7.44e-34	136.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales	135613|Chromatiales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5151863_9	648757.Rvan_1535	2.471e-16	91.0	COG0810@1|root,COG0810@2|Bacteria,1PVW4@1224|Proteobacteria,2V740@28211|Alphaproteobacteria,3N8Y7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_5151863_1	582899.Hden_2125	8.705e-200	627.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,3N6D6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_5151863_3	1267005.KB911258_gene484	6.396e-77	268.0	COG0580@1|root,COG0580@2|Bacteria,1PPTN@1224|Proteobacteria,2TW8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	-	-	-	-	-	-	-	-	-	MIP
HKD1_k127_5151863_2	1267005.KB911258_gene483	3.548e-87	296.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,3N6QZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
HKD1_k127_5151863_5	1267005.KB911258_gene482	4.488e-47	171.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,3N7FE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HKD1_k127_5167058_2	1267005.KB911260_gene3401	1.023e-273	859.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5167058_7	582899.Hden_1055	1.201e-26	119.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_5167058_4	1267005.KB911261_gene2355	3.785e-99	344.0	COG2885@1|root,COG2885@2|Bacteria,1PQ3A@1224|Proteobacteria,2TRBD@28211|Alphaproteobacteria,3N6W1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	OmpA family	MA20_43500	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_5167058_8	670292.JH26_19100	8.849e-11	63.0	COG4095@1|root,COG4095@2|Bacteria,1N759@1224|Proteobacteria,2UG31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	PQ-loop
HKD1_k127_5167058_9	313612.L8106_29825	0.0001267	49.0	COG4095@1|root,COG4095@2|Bacteria,1G9AI@1117|Cyanobacteria,1HCTA@1150|Oscillatoriales	1117|Cyanobacteria	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
HKD1_k127_5167058_6	395965.Msil_2275	1.114e-62	222.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,2U7N6@28211|Alphaproteobacteria,3NA5D@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Methylpurine-DNA glycosylase (MPG)	-	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD1_k127_5167058_3	1267005.KB911261_gene2312	5.455e-130	424.0	COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,3N65R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HKD1_k127_5167058_0	717785.HYPMC_4445	0.0	1708.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,3N6I3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
HKD1_k127_5167058_1	717785.HYPMC_4444	1e-323	1011.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,3N68A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Circularly permuted ATP-grasp type 2	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
HKD1_k127_5167058_5	717785.HYPMC_4443	1.92e-63	227.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TRFC@28211|Alphaproteobacteria,3N6WJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_5168278_1	1054213.HMPREF9946_04300	1.098e-17	90.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver	MA20_41525	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_5168278_0	1430440.MGMSRv2_0854	1.463e-55	203.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2JS5Q@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HKD1_k127_5176579_6	1267005.KB911257_gene736	1.052e-79	274.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,3N6BM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_5176579_8	582899.Hden_3349	9.994e-23	106.0	2BXM2@1|root,3159P@2|Bacteria,1PVB8@1224|Proteobacteria,2V74V@28211|Alphaproteobacteria,3N905@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2628)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2628
HKD1_k127_5176579_3	670307.HYPDE_40108	1.742e-109	363.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,3N6PK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9,3.1.3.15,4.2.1.19	ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03013,R03243,R03457	RC00006,RC00017,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	IGPD
HKD1_k127_5176579_5	582899.Hden_3347	1.354e-93	310.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,3N6QN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD1_k127_5176579_7	391896.A1I_07125	1.663e-24	106.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,2UBR4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Small multidrug resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD1_k127_5176579_0	1267005.KB911257_gene742	1.292e-227	710.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,3N6AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_5176579_1	231434.JQJH01000005_gene2200	5.276e-182	578.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NAFW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
HKD1_k127_5176579_4	231434.JQJH01000005_gene2200	2.919e-106	349.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NAFW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4994,Sulfatase
HKD1_k127_5176579_2	595536.ADVE02000001_gene1161	1.32e-112	373.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,3718A@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_5181_6	314285.KT71_03885	4.093e-10	63.0	2DQEQ@1|root,336DG@2|Bacteria,1NI38@1224|Proteobacteria,1STU7@1236|Gammaproteobacteria,1JBBU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5181_4	1267005.KB911260_gene3581	2.49e-103	341.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,3N6QX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD1_k127_5181_2	582899.Hden_1845	1.8e-196	622.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,3N6AJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5181_5	1267005.KB911264_gene3203	5.913e-100	332.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3N6PA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD1_k127_5181_3	1380394.JADL01000001_gene3072	2.36e-141	460.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales	204441|Rhodospirillales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD1_k127_5181_1	1267005.KB911261_gene2257	1.187e-225	708.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,3N6KT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
HKD1_k127_5181_0	1267005.KB911261_gene2253	3.092e-278	865.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,3N69B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_5184455_2	1123257.AUFV01000002_gene2759	1.623e-100	339.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,1RP4I@1236|Gammaproteobacteria,1X63I@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD1_k127_5184455_1	1079460.ATTQ01000010_gene140	8.066e-221	692.0	COG1052@1|root,COG1052@2|Bacteria,1PDP1@1224|Proteobacteria,2U0EU@28211|Alphaproteobacteria,4BBBN@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms	fdh	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_5184455_0	1267005.KB911257_gene709	8.527e-248	776.0	COG2303@1|root,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,2U7D4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EI	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD1_k127_5184455_3	717785.HYPMC_3848	1.591e-91	306.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,3N6T7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_5185578_0	717785.HYPMC_4584	1.158e-315	977.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,3N66E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_5185578_2	670307.HYPDE_39598	5.166e-61	216.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3N73R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD1_k127_5185578_1	582899.Hden_3251	3.356e-86	291.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,3N6WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD1_k127_5193619_4	1267005.KB911255_gene2600	1.898e-96	320.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,3N61I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_5193619_0	1267005.KB911255_gene2599	0.0	1095.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,3N6KP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_5193619_7	1267005.KB911255_gene2598	2.102e-71	248.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,3N73N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_5193619_1	1267005.KB911255_gene2597	4.664e-170	540.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,3N69P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD1_k127_5193619_3	1267005.KB911255_gene2596	3.288e-136	436.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,3N6E9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_5193619_8	1267005.KB911255_gene2595	4.062e-59	210.0	2B0DW@1|root,31SR8@2|Bacteria,1RHKN@1224|Proteobacteria,2UB8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1772)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1772
HKD1_k127_5193619_10	935840.JAEQ01000001_gene2824	2.351e-51	190.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria,43K76@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	bleomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5193619_5	1267005.KB911255_gene2593	2.504e-93	312.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,3N6S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_5193619_2	582899.Hden_3391	1.843e-164	531.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,3N68E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_5193619_6	717785.HYPMC_4708	1.529e-92	317.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,3N6YN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_5193619_9	1267005.KB911255_gene2590	2.937e-55	198.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,3N77P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Disulfide bond formation protein DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HKD1_k127_5223387_0	1380394.JADL01000012_gene1063	5.571e-136	444.0	COG0793@1|root,COG0793@2|Bacteria,1MX41@1224|Proteobacteria,2U26V@28211|Alphaproteobacteria,2JYCC@204441|Rhodospirillales	204441|Rhodospirillales	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_5223387_1	266117.Rxyl_2895	2.039e-17	87.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,4CTPZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_522364_0	1267005.KB911255_gene3024	5.28e-99	334.0	2C50M@1|root,32YGT@2|Bacteria,1NK10@1224|Proteobacteria,2UY4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_522364_2	717785.HYPMC_2980	4.272e-78	280.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,3N8MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
HKD1_k127_522364_3	663610.JQKO01000016_gene1595	3.944e-55	200.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2U7V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD1_k127_522364_1	663610.JQKO01000002_gene1223	1.007e-90	304.0	COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,2TRJM@28211|Alphaproteobacteria,3NCG2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_5227505_4	395964.KE386496_gene2905	5.174e-84	282.0	COG2863@1|root,COG2863@2|Bacteria,1PFS2@1224|Proteobacteria,2V88Y@28211|Alphaproteobacteria,3NBVX@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_5227505_0	670307.HYPDE_33028	3.998e-203	638.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,3N61B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5227505_1	670307.HYPDE_33048	1.596e-159	513.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,3N63V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
HKD1_k127_5227505_3	717785.HYPMC_2779	3.813e-87	291.0	COG1846@1|root,COG1846@2|Bacteria,1RA1V@1224|Proteobacteria,2U5W6@28211|Alphaproteobacteria,3N6ZY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	mucS	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD1_k127_5227505_2	1267005.KB911259_gene3701	1.479e-135	441.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,3N70K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	hibch	-	3.1.2.4,4.2.1.17	ko:K01692,ko:K05605	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00013,M00032,M00087	R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093	RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
HKD1_k127_5230702_17	1150626.PHAMO_200066	1.423e-40	156.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JUZE@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5230702_9	1267005.KB911260_gene3394	2.776e-104	348.0	COG2374@1|root,COG2374@2|Bacteria,1R7ZN@1224|Proteobacteria,2U15A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_5230702_12	717785.HYPMC_3234	5.161e-48	176.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3N72F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_5230702_20	1123229.AUBC01000007_gene112	5.355e-26	109.0	2EB0P@1|root,3351I@2|Bacteria,1NAEB@1224|Proteobacteria,2UG0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5230702_1	622637.KE124774_gene3894	3.565e-240	758.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,36XN8@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase N terminal	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HKD1_k127_5230702_15	1134912.AJTV01000028_gene2045	1.637e-41	164.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,2U85S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_5230702_18	717785.HYPMC_3318	3.688e-39	151.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,2UFG2@28211|Alphaproteobacteria,3N78M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD1_k127_5230702_21	234267.Acid_5771	2.139e-19	93.0	COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_5230702_10	1267005.KB911259_gene4009	3.164e-93	311.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5230702_2	1267005.KB911259_gene4008	2.149e-191	612.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,2UQ4Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD1_k127_5230702_19	1122604.JONR01000009_gene2455	1.732e-29	123.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S8NE@1236|Gammaproteobacteria,1X8FQ@135614|Xanthomonadales	135614|Xanthomonadales	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_5230702_14	1267005.KB911259_gene4007	9.763e-45	172.0	2D1BA@1|root,32TAA@2|Bacteria,1RJQD@1224|Proteobacteria,2U780@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5230702_5	1121861.KB899946_gene3939	8.341e-135	438.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,2JR9U@204441|Rhodospirillales	204441|Rhodospirillales	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HKD1_k127_5230702_3	1267005.KB911259_gene4030	9.772e-158	513.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,3N89U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zeta toxin	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD1_k127_5230702_6	335659.S23_53130	8.254e-126	417.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,3JWKN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
HKD1_k127_5230702_0	1267005.KB911259_gene4012	0.0	1178.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3N6MD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CJ	CoA binding domain	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_5230702_11	582899.Hden_0595	4.755e-52	194.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2U36S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	fixK	-	-	ko:K01420,ko:K15861	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_5230702_7	670307.HYPDE_25693	5.308e-113	376.0	COG1463@1|root,COG3218@1|root,COG1463@2|Bacteria,COG3218@2|Bacteria,1NNAG@1224|Proteobacteria,2TSCH@28211|Alphaproteobacteria,3N765@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ABC-type transport auxiliary lipoprotein component	MA20_38065	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_trans_aux,MlaD
HKD1_k127_5230702_8	876269.ARWA01000001_gene1917	1.026e-111	366.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,3NAWW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	yrbF	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_5230702_4	323097.Nham_1921	2.118e-137	447.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,3JSFD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
HKD1_k127_5230702_16	670307.HYPDE_25718	7.271e-41	156.0	COG2010@1|root,COG2010@2|Bacteria,1PYBA@1224|Proteobacteria,2VAHA@28211|Alphaproteobacteria,3N991@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_5230702_13	1267005.KB911259_gene3777	3.086e-47	175.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,3N72F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_5246585_0	582899.Hden_2493	2.135e-244	766.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3N8K5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	MA20_01895	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD1_k127_5246585_2	1267005.KB911256_gene1509	2.299e-46	171.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,3N744@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	RF-1 domain	MA20_05665	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD1_k127_5246585_3	1211115.ALIQ01000241_gene3342	3.884e-35	139.0	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2UBXR@28211|Alphaproteobacteria,3NBNS@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Small Multidrug Resistance protein	qacE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD1_k127_5246585_1	1267005.KB911256_gene2073	1.616e-49	179.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N8X3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
HKD1_k127_5247097_0	1267005.KB911255_gene2540	0.0	1039.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,3N69J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_5247097_3	582899.Hden_0365	6.695e-33	138.0	COG3108@1|root,COG3108@2|Bacteria	2|Bacteria	S	Peptidase M15	-	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Peptidase_M15_2,Peptidase_M15_3
HKD1_k127_5247097_4	1267005.KB911255_gene2528	1.618e-32	134.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3N78I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_5247097_2	1267005.KB911255_gene2527	5.108e-43	160.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,3N72A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_5247097_1	1267005.KB911256_gene1446	6.3e-81	276.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2U81X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD1_k127_5247097_5	743720.Psefu_1028	4.905e-28	130.0	COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria	1224|Proteobacteria	T	ggdef domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,GGDEF,PAS,PAS_3,dCache_1
HKD1_k127_5247097_7	395964.KE386496_gene3134	1.857e-05	47.0	COG4106@1|root,COG4106@2|Bacteria,1QWJU@1224|Proteobacteria,2TWZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_5270057_16	582899.Hden_1139	4.938e-12	72.0	COG5612@1|root,COG5612@2|Bacteria	2|Bacteria	S	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HKD1_k127_5270057_17	670307.HYPDE_31968	7.246e-11	70.0	2EG2K@1|root,339UJ@2|Bacteria,1NG8N@1224|Proteobacteria,2UJI4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5270057_9	717785.HYPMC_2360	3.636e-68	237.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,3N7C5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	sigE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_5270057_0	1267005.KB911258_gene395	0.0	1191.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,3N6D8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD1_k127_5270057_4	717785.HYPMC_2362	2.401e-155	505.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N61U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5270057_6	670307.HYPDE_31988	1.63e-125	405.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,3N698@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	ragA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5270057_3	717785.HYPMC_2364	9.944e-167	539.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3N6BK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_5270057_12	1101192.KB910516_gene3485	8.434e-37	159.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,1JV9J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD1_k127_5270057_1	1267005.KB911258_gene389	0.0	1014.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,3N6JZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD1_k127_5270057_11	1267005.KB911258_gene388	2.768e-62	219.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,3N71D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD1_k127_5270057_7	670307.HYPDE_32013	4.254e-93	318.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,3N752@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
HKD1_k127_5270057_10	1267005.KB911258_gene386	3.378e-66	228.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,3N7G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycine zipper 2TM domain	omp	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti
HKD1_k127_5270057_2	582899.Hden_1127	1.803e-183	593.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,3N6N6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	feuQ	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
HKD1_k127_5270057_5	1267005.KB911258_gene384	1.536e-127	409.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,3N6AA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	feuP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5270057_15	1349767.GJA_5242	6.109e-13	78.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2VSZQ@28216|Betaproteobacteria,477EV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1428)	ybaA	-	-	-	-	-	-	-	-	-	-	-	DUF1428
HKD1_k127_5270057_14	504832.OCAR_4758	1.069e-21	97.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,3JYUE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
HKD1_k127_5270057_13	1267005.KB911258_gene383	8.439e-24	103.0	COG3926@1|root,COG3926@2|Bacteria,1QV3R@1224|Proteobacteria,2UDA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl hydrolase 108	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
HKD1_k127_5274776_2	1267005.KB911265_gene3636	3.676e-131	422.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,3N6KS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HKD1_k127_5274776_0	717785.HYPMC_0817	5.548e-154	506.0	COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,2U5VC@28211|Alphaproteobacteria,3N972@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,DUF262
HKD1_k127_5274776_3	1040989.AWZU01000022_gene4762	1.32e-31	128.0	COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,3JZ4V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF952)	MA20_22095	-	-	-	-	-	-	-	-	-	-	-	DUF952
HKD1_k127_5274776_1	1267005.KB911265_gene3633	1.421e-146	476.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,3N6G1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5274776_4	1267005.KB911265_gene3632	9.582e-16	79.0	2CAZC@1|root,32ZW8@2|Bacteria,1Q6SJ@1224|Proteobacteria,2VCII@28211|Alphaproteobacteria,3N7FQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5278237_4	1267005.KB911258_gene625	6.005e-119	395.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,3N64B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD1_k127_5278237_10	1415778.JQMM01000001_gene215	3.727e-28	118.0	COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,1RMES@1236|Gammaproteobacteria,1JBEG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Bacterial regulatory helix-turn-helix protein, lysR family	modE	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
HKD1_k127_5278237_3	670307.HYPDE_31433	1.083e-135	449.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3N6CE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_5278237_5	1267005.KB911258_gene628	7.625e-111	364.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria,3N6Q1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_5278237_8	1267005.KB911259_gene3995	3.057e-45	169.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,3N8XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_5278237_1	1267005.KB911259_gene3901	9.799e-243	758.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,3N6F1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_5278237_2	1267005.KB911259_gene3902	2.772e-166	543.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,3N6PH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
HKD1_k127_5278237_6	1267005.KB911259_gene3903	2.864e-99	332.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,3N6NM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_5278237_9	717785.HYPMC_1597	1.219e-35	140.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,3N794@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_5278237_0	1267005.KB911259_gene3907	0.0	1000.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,3N6G8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_5278237_7	1123279.ATUS01000001_gene2584	3.301e-46	170.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1J60G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Nitrogen regulatory protein P-II	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_5278237_11	1163408.UU9_14240	2.234e-18	89.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria,1X8UE@135614|Xanthomonadales	135614|Xanthomonadales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_5279845_4	1267005.KB911257_gene1077	6.324e-35	136.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3N63N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
HKD1_k127_5279845_0	1267005.KB911257_gene1076	1.72e-289	908.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3N6A8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD1_k127_5279845_1	670307.HYPDE_22738	5.079e-145	468.0	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2U5IP@28211|Alphaproteobacteria,3N7IT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
HKD1_k127_5279845_2	1267005.KB911257_gene1074	1.735e-83	288.0	COG3637@1|root,COG3637@2|Bacteria,1RBBG@1224|Proteobacteria,2U5ED@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lipid A oxidase	lpxQ	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	OMP_b-brl
HKD1_k127_5279845_3	717785.HYPMC_0050	4.955e-70	248.0	COG1511@1|root,COG1511@2|Bacteria,1QY7Q@1224|Proteobacteria,2TXIQ@28211|Alphaproteobacteria,3N82W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
HKD1_k127_5305482_2	717785.HYPMC_4525	2.719e-175	555.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_5305482_3	717785.HYPMC_4526	8.971e-157	499.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,3N634@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_5305482_0	670307.HYPDE_39483	4.031e-194	611.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3N66U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_5305482_1	1267005.KB911257_gene1091	7.779e-182	574.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,3N6B6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_5305482_4	1267005.KB911261_gene2320	1.376e-57	209.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,2UAH9@28211|Alphaproteobacteria,3N8UV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD1_k127_5312590_2	1267005.KB911257_gene896	8.149e-85	291.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria,3N92Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_25205	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	SEC-C,adh_short
HKD1_k127_5312590_1	639283.Snov_2292	6.252e-188	596.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TUTC@28211|Alphaproteobacteria,3F096@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD1_k127_5312590_0	876269.ARWA01000001_gene3245	0.0	1328.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3N9K5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_534501_13	1267005.KB911255_gene2428	2.499e-59	215.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,3N6WH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
HKD1_k127_534501_5	1267005.KB911255_gene2429	1.45e-151	493.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,3N6K5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD1_k127_534501_4	1267005.KB911255_gene2430	3.96e-167	531.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,3N6BE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_534501_0	717785.HYPMC_4073	2.485e-210	659.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,3N86Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_534501_7	1267005.KB911255_gene2436	1.327e-105	345.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2TTNQ@28211|Alphaproteobacteria,3N8FF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD1_k127_534501_10	1267005.KB911255_gene2437	4.008e-89	299.0	COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria,3N6ZM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	MA20_39625	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_534501_8	1267005.KB911255_gene2438	2.4e-96	336.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,3N6SN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD1_k127_534501_15	670307.HYPDE_37603	1.703e-53	198.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2U962@28211|Alphaproteobacteria,3N75P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cupin superfamily (DUF985)	MA20_39615	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HKD1_k127_534501_2	1267005.KB911255_gene2440	2.546e-203	648.0	COG0810@1|root,COG1432@1|root,COG0810@2|Bacteria,COG1432@2|Bacteria,1Q0F0@1224|Proteobacteria,2UC1N@28211|Alphaproteobacteria,3N8A0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_534501_6	1267005.KB911255_gene2441	1.612e-125	404.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,3N82B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD1_k127_534501_3	189753.AXAS01000018_gene3275	5.326e-195	614.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3JRMV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_534501_9	1267005.KB911255_gene2443	1.73e-89	299.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,3N8EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD1_k127_534501_17	670307.HYPDE_37633	1.721e-39	151.0	2E6XE@1|root,331GU@2|Bacteria,1N7WP@1224|Proteobacteria,2UG23@28211|Alphaproteobacteria,3N93P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_534501_19	670307.HYPDE_37638	6.812e-26	107.0	COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria,3N775@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_534501_12	1267005.KB911255_gene2447	5.006e-74	266.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,3N6XY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD1_k127_534501_14	717785.HYPMC_4087	3.064e-54	200.0	COG3637@1|root,COG3637@2|Bacteria,1NJWW@1224|Proteobacteria,2UD8G@28211|Alphaproteobacteria,3N8SQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD1_k127_534501_16	717785.HYPMC_0028	5.247e-51	184.0	2EE7W@1|root,3382F@2|Bacteria,1NFC5@1224|Proteobacteria,2UINU@28211|Alphaproteobacteria,3N8WG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD1_k127_534501_1	1267005.KB911255_gene2453	1.718e-209	657.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,3N63A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD1_k127_534501_11	1267005.KB911255_gene2454	6.105e-87	295.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,3N6SB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ABC 3 transport family	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD1_k127_5349550_11	670307.HYPDE_30483	1.282e-28	115.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3N6J2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_5349550_6	582899.Hden_1721	1.027e-120	400.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,3N693@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_5349550_2	717785.HYPMC_2038	8.277e-219	686.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,3N6HQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HKD1_k127_5349550_10	1267005.KB911258_gene588	1.827e-48	180.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2TUVR@28211|Alphaproteobacteria,3N7BD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD1_k127_5349550_1	1267005.KB911258_gene587	2.154e-271	842.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,3N6GX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD1_k127_5349550_8	670307.HYPDE_30508	1.789e-107	353.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria,3N6MR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_5349550_7	670307.HYPDE_30518	2.583e-115	377.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,3N6M2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HKD1_k127_5349550_4	582899.Hden_1728	3.444e-128	414.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,3N6BD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_5349550_0	1267005.KB911258_gene583	1.517e-272	846.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,3N62K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD1_k127_5349550_5	1267005.KB911258_gene582	1.212e-127	421.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,3N73W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HKD1_k127_5349550_9	639283.Snov_1770	5.666e-64	226.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,3EZ70@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_5349550_3	717785.HYPMC_2028	2.212e-128	419.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,3N629@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_5349588_3	717785.HYPMC_2028	1.559e-16	79.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,3N629@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_5349588_1	1207063.P24_03720	3.197e-155	503.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,2TRC0@28211|Alphaproteobacteria,2JQGH@204441|Rhodospirillales	204441|Rhodospirillales	S	Permease family	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD1_k127_5349588_2	717785.HYPMC_2798	1.554e-133	439.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria,3N7QN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA	-	-	ko:K07799,ko:K18990	ko02020,map02020	M00648,M00720	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_5349588_0	670307.HYPDE_33123	0.0	1093.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N80J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtB	-	-	ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5397119_14	1267005.KB911257_gene749	4.518e-87	290.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,3N6HN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_5397119_21	1267005.KB911256_gene1477	2.547e-44	167.0	2DMJE@1|root,32RYR@2|Bacteria,1N7PS@1224|Proteobacteria,2UFEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HKD1_k127_5397119_0	1267005.KB911256_gene1479	6.735e-206	661.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3N63C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_5397119_13	1120705.FG95_02124	4.897e-90	300.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria,2K5DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1993)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1993
HKD1_k127_5397119_10	1267005.KB911256_gene1482	2.665e-108	357.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,3N705@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD1_k127_5397119_17	1267005.KB911257_gene712	9.982e-62	218.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,3N74Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	protein SCO1 SenC	msp5	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_5397119_2	1267005.KB911257_gene715	4.392e-157	507.0	COG0642@1|root,COG0642@2|Bacteria,1QU3Y@1224|Proteobacteria,2TVYH@28211|Alphaproteobacteria,3N9IC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD1_k127_5397119_11	670307.HYPDE_22593	2.37e-102	337.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria,3N6P2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	response regulator	actR	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
HKD1_k127_5397119_20	1267005.KB911257_gene717	7.538e-52	192.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,3N73Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	DNA repair protein MmcB-like	MA20_23405	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
HKD1_k127_5397119_8	1267005.KB911257_gene718	2.343e-129	434.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2TU7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD1_k127_5397119_18	1267005.KB911257_gene719	7.594e-56	212.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
HKD1_k127_5397119_22	1206777.B195_01145	2.799e-30	134.0	COG1073@1|root,COG1073@2|Bacteria,1RBF1@1224|Proteobacteria,1SHV5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5397119_15	717785.HYPMC_0091	6.479e-83	282.0	COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,2U7HD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein tyrosine serine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF442,Y_phosphatase3
HKD1_k127_5397119_16	1333998.M2A_2478	1.599e-76	263.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
HKD1_k127_5397119_7	1267005.KB911257_gene948	1.016e-129	421.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3N6FG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk_2	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0042802,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD1_k127_5397119_4	1267005.KB911257_gene947	7.093e-133	437.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,3N6NS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
HKD1_k127_5397119_1	1040986.ATYO01000006_gene309	4.709e-171	542.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2TTJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_5397119_3	1187851.A33M_3704	3.681e-148	475.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,3FDA6@34008|Rhodovulum	28211|Alphaproteobacteria	U	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_5397119_6	582899.Hden_0298	5.742e-130	419.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	phosphate transport system permease	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_5397119_5	582899.Hden_0297	1.302e-131	432.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,3N6BG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_5397119_9	1267005.KB911257_gene1081	1.237e-119	390.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,3N6SQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_5397119_12	1267005.KB911257_gene1080	1.747e-96	317.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,3N6CS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator PhoB, winged helix family	phoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5431980_3	582899.Hden_0312	1.454e-11	68.0	COG4961@1|root,COG4961@2|Bacteria,1N744@1224|Proteobacteria,2UGR2@28211|Alphaproteobacteria,3N7FP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD1_k127_5431980_1	1267005.KB911259_gene3822	4.136e-55	199.0	COG1309@1|root,COG1309@2|Bacteria,1N0XU@1224|Proteobacteria,2U82V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD1_k127_5431980_0	670307.HYPDE_24073	1.998e-98	331.0	COG1988@1|root,COG3170@1|root,COG1988@2|Bacteria,COG3170@2|Bacteria,1MZEI@1224|Proteobacteria,2UEUZ@28211|Alphaproteobacteria,3N8E2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
HKD1_k127_5431980_2	1267005.KB911259_gene3820	7.049e-25	106.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,3N6D3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_5442144_5	717785.HYPMC_2679	2.667e-110	373.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria,3N6XP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	DM	Lysin motif	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
HKD1_k127_5442144_12	595536.ADVE02000001_gene3917	2.26e-27	121.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2UC1Q@28211|Alphaproteobacteria,370RI@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HKD1_k127_5442144_4	1267005.KB911260_gene3439	1.38e-131	427.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,3N657@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF815)	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD1_k127_5442144_7	1267005.KB911260_gene3440	7.337e-43	159.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,3N76E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_5442144_2	991905.SL003B_2204	2.808e-171	553.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,4BPMN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_5442144_3	670307.HYPDE_29388	8.689e-134	435.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,3N8AQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_5442144_8	717785.HYPMC_2674	8.897e-36	140.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VCBI@28211|Alphaproteobacteria,3N97Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD1_k127_5442144_10	648757.Rvan_0688	6.852e-32	135.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria,3N72M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291,ko:K18163	ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
HKD1_k127_5442144_0	1267005.KB911260_gene3445	1.856e-259	817.0	2A2JU@1|root,30QXU@2|Bacteria,1N7N4@1224|Proteobacteria,2TTU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08245	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5442144_1	1267005.KB911256_gene1526	4.781e-237	740.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,3N6EM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD1_k127_5442144_6	582899.Hden_1280	8.916e-104	350.0	COG4872@1|root,COG4872@2|Bacteria,1N2XF@1224|Proteobacteria,2UDAH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HKD1_k127_5442144_9	1267005.KB911256_gene1534	9.488e-35	151.0	COG4929@1|root,COG4929@2|Bacteria,1NURJ@1224|Proteobacteria,2TV9N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
HKD1_k127_5444727_0	1267005.KB911263_gene1270	1.002e-253	803.0	COG1196@1|root,COG1196@2|Bacteria,1MVEP@1224|Proteobacteria,2TR50@28211|Alphaproteobacteria,3N6WD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein
HKD1_k127_5444727_2	460265.Mnod_4475	1.288e-104	351.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,1JSU1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	ycjG	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_5444727_1	1267005.KB911263_gene1268	8.988e-110	370.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,3N73D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HKD1_k127_5463465_4	582899.Hden_0407	2.073e-40	153.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,3N8GZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_5463465_3	717785.HYPMC_0806	5.144e-41	152.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
HKD1_k127_5463465_0	1267005.KB911256_gene1877	1.003e-208	667.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,3N7PS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD1_k127_5463465_1	648757.Rvan_3132	2.43e-158	506.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,3N7J7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_5463465_2	1247963.JPHU01000006_gene193	2.169e-49	183.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	secondary thiamine-phosphate synthase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_5492267_1	1267005.KB911260_gene3528	1.656e-66	228.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,3N6U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD1_k127_5492267_0	1267005.KB911260_gene3527	4.893e-231	734.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,2U9Q1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	low-complexity proteins	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD1_k127_5492267_2	1267005.KB911260_gene3526	4.478e-48	174.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_5499899_1	1267005.KB911256_gene1499	2.049e-164	521.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,3N6CK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_5499899_3	670307.HYPDE_36093	2.454e-65	228.0	COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria,3N715@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	petP	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD1_k127_5499899_2	670307.HYPDE_36098	7.067e-110	360.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,3N7ZT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Two component transcriptional regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5499899_0	1267005.KB911256_gene1496	1.259e-224	706.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,3N804@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5499899_4	648757.Rvan_3051	2.668e-44	170.0	COG1309@1|root,COG1309@2|Bacteria,1QE3S@1224|Proteobacteria,2U3XG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_5499899_5	323098.Nwi_2514	1.348e-31	125.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,3JR3K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_5511536_1	670307.HYPDE_36563	4.103e-117	383.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,3N6JT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_5511536_2	717785.HYPMC_3834	1.514e-76	270.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,3N6TT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD1_k127_5511536_4	1122981.AUME01000031_gene1053	2.105e-14	76.0	COG1983@1|root,COG1983@2|Bacteria,4NX1N@976|Bacteroidetes,2FUW2@200643|Bacteroidia	976|Bacteroidetes	KT	PspC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PspC
HKD1_k127_5511536_5	452662.SJA_C1-07110	1.185e-13	82.0	COG2010@1|root,COG2010@2|Bacteria,1N8V1@1224|Proteobacteria,2UG8G@28211|Alphaproteobacteria,2KBN9@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5511536_3	1469607.KK073768_gene1866	3.195e-26	120.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8,Trypsin_2
HKD1_k127_5511536_0	1267005.KB911255_gene2700	6.005e-164	525.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,3N662@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_55891_9	113395.AXAI01000005_gene3801	7.697e-27	114.0	28MT5@1|root,2ZB1G@2|Bacteria,1RC18@1224|Proteobacteria,2U40K@28211|Alphaproteobacteria,3JUHA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_55891_7	693986.MOC_1810	9.664e-39	150.0	28MT5@1|root,2ZB1G@2|Bacteria,1RC18@1224|Proteobacteria,2U40K@28211|Alphaproteobacteria,1JU4K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_55891_5	1121035.AUCH01000005_gene125	7.491e-72	253.0	COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria	1224|Proteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HKD1_k127_55891_6	717785.HYPMC_0851	9.59e-44	162.0	COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria,3N8TA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_55891_0	1267005.KB911259_gene4020	8.538e-306	944.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,3N7QH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HKD1_k127_55891_4	1267005.KB911259_gene4019	3.05e-124	402.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,3N7X4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	cytochrome C	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD1_k127_55891_11	648757.Rvan_2925	6.291e-10	61.0	COG4736@1|root,COG4736@2|Bacteria	2|Bacteria	O	Cbb3-type cytochrome oxidase	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HKD1_k127_55891_3	1267005.KB911259_gene4017	1.723e-137	442.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,3N851@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD1_k127_55891_2	1267005.KB911259_gene4016	1.892e-231	725.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,3N88Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase accessory protein CcoG	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD1_k127_55891_8	670307.HYPDE_28153	1.523e-36	149.0	COG5456@1|root,COG5456@2|Bacteria	2|Bacteria	P	FixH	fixH	-	-	-	-	-	-	-	-	-	-	-	FixH
HKD1_k127_55891_1	1267005.KB911259_gene4014	5.234e-260	822.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3N7P7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_55891_10	1267005.KB911259_gene4013	8.873e-15	79.0	COG3197@1|root,COG3197@2|Bacteria	2|Bacteria	P	Cytochrome oxidase maturation protein	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
HKD1_k127_5625672_1	717785.HYPMC_4889	7.717e-105	343.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,3N67K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_5625672_0	670307.HYPDE_40928	1.333e-144	473.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,3N6TS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Peptidase family M23	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_5625672_3	670307.HYPDE_40938	8.39e-91	304.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,3N6RB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cobalamin adenosyltransferase	MA20_20540	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD1_k127_5625672_2	1267005.KB911257_gene1118	1.429e-98	329.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,3N6YY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_5625672_5	460265.Mnod_0460	5.508e-11	62.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,1JSPC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Electron transfer flavoprotein alpha beta-subunit	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_5626719_4	582899.Hden_2390	1.004e-21	98.0	2968C@1|root,2ZTID@2|Bacteria,1P7TY@1224|Proteobacteria,2UWB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5626719_0	1267005.KB911256_gene1467	0.0	1117.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N7YM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD1_k127_5626719_1	582899.Hden_0216	5.998e-261	809.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria,3N7S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	reductase	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5626719_2	1267005.KB911256_gene1462	6.282e-107	354.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ribonuclease, BN	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_5654703_1	1267005.KB911257_gene1022	6.025e-97	319.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3N6AE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_5654703_2	717785.HYPMC_4635	9.536e-94	318.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2TSQ0@28211|Alphaproteobacteria,3N6P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD1_k127_5654703_0	1267005.KB911257_gene1025	1.671e-112	369.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,3N62S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_5654703_3	1267005.KB911257_gene1027	2.781e-70	242.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,3N944@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	GCN5-related N-acetyltransferase	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_5654703_4	1267005.KB911257_gene1028	1.41e-44	167.0	COG5490@1|root,COG5490@2|Bacteria	2|Bacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_5656323_5	717785.HYPMC_3975	5.982e-85	283.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2U220@28211|Alphaproteobacteria,3N6KK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	ANTAR	nasT	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
HKD1_k127_5656323_3	582899.Hden_2948	7.921e-204	640.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,3N62Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	nrt	-	-	ko:K15576,ko:K22067	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000,ko02022	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
HKD1_k127_5656323_2	670307.HYPDE_25603	1.047e-209	661.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2TSXZ@28211|Alphaproteobacteria,3N7KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	narK	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_5656323_0	717785.HYPMC_3972	0.0	1482.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,3N6HV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitrite reductase NAD(P)H , large subunit	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
HKD1_k127_5656323_8	1297569.MESS2_1080005	3.61e-57	199.0	COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2UC33@28211|Alphaproteobacteria,43KIV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Rieske-like [2Fe-2S] domain	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
HKD1_k127_5656323_1	670307.HYPDE_25588	0.0	1289.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,3N6FX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nasA	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_5656323_6	663610.JQKO01000002_gene1210	7.682e-74	259.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,3N9U7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cobA	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD1_k127_5656323_4	717785.HYPMC_3978	5.081e-158	511.0	COG3203@1|root,COG3203@2|Bacteria,1N1M5@1224|Proteobacteria,2UEVI@28211|Alphaproteobacteria,3N9I7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HKD1_k127_5656323_11	796940.HMPREF9628_00545	1.519e-13	71.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_5656323_7	1126627.BAWE01000005_gene5701	1.556e-58	213.0	COG1887@1|root,COG1887@2|Bacteria,1QXED@1224|Proteobacteria,2UDIS@28211|Alphaproteobacteria,3JXBT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5656323_9	1038862.KB893833_gene4704	1.677e-52	190.0	COG1887@1|root,COG1887@2|Bacteria,1QXED@1224|Proteobacteria,2UDIS@28211|Alphaproteobacteria,3JXBT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5656323_10	1122135.KB893134_gene3931	2.178e-16	92.0	2DWIE@1|root,340GU@2|Bacteria,1NZ7I@1224|Proteobacteria,2USW7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_565850_11	663610.JQKO01000025_gene252	4.279e-29	117.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_565850_7	663610.JQKO01000025_gene251	2.697e-49	177.0	arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria,2U9X3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HKD1_k127_565850_8	1280950.HJO_09874	2.571e-46	174.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,43XK4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	intracellular protease amidase	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_565850_13	990285.RGCCGE502_06019	8.262e-23	104.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,4BEVZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	DJ-1/PfpI family	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_565850_5	754035.Mesau_04349	1.103e-85	291.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TU0G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_565850_6	670307.HYPDE_30603	1.521e-58	207.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2UAEV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD1_k127_565850_10	1187851.A33M_3863	1.673e-34	138.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_565850_12	1114964.L485_02250	6.149e-24	109.0	2EIQJ@1|root,33CG0@2|Bacteria,1NISZ@1224|Proteobacteria,2UIRN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_565850_3	717785.HYPMC_0222	3.36e-101	333.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2TQWX@28211|Alphaproteobacteria,3N8J3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD1_k127_565850_9	717785.HYPMC_0220	2.274e-41	155.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2U9QA@28211|Alphaproteobacteria,3N8NR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	zntR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
HKD1_k127_565850_0	717785.HYPMC_2503	2.187e-240	748.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,3N7W8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	metY	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_565850_1	420324.KI911996_gene7864	5.42e-181	583.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,2TWFC@28211|Alphaproteobacteria,1JZGX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HKD1_k127_565850_2	1267005.KB911256_gene1940	4.484e-144	461.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3N805@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK,Zn_protease
HKD1_k127_565850_4	1267005.KB911256_gene1939	2.312e-96	317.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,3N6SD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD1_k127_5679842_1	1038859.AXAU01000008_gene2022	4.801e-137	451.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_5679842_0	717785.HYPMC_3870	9.255e-186	589.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_5679842_5	990285.RGCCGE502_03217	1.139e-06	57.0	COG0784@1|root,COG0784@2|Bacteria,1P03Q@1224|Proteobacteria,2UU2J@28211|Alphaproteobacteria,4BE8S@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_5679842_2	313612.L8106_09501	1.754e-42	170.0	COG2202@1|root,COG4251@1|root,COG5000@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5000@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_5679842_6	69293.ENSGACP00000022177	4.554e-06	52.0	COG1100@1|root,KOG0097@2759|Eukaryota,38EZ9@33154|Opisthokonta,3BBM7@33208|Metazoa,3CZZI@33213|Bilateria,487XT@7711|Chordata,48W16@7742|Vertebrata	33208|Metazoa	U	Golgi to endosome transport	RAB14	GO:0000166,GO:0000323,GO:0001775,GO:0001845,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005783,GO:0005791,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006793,GO:0006796,GO:0006810,GO:0006873,GO:0006885,GO:0006887,GO:0006892,GO:0006895,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007264,GO:0007265,GO:0007589,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008543,GO:0008610,GO:0008654,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009987,GO:0010008,GO:0010033,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016324,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019637,GO:0019725,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030100,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030641,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031489,GO:0031901,GO:0031982,GO:0031984,GO:0032456,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036477,GO:0042119,GO:0042175,GO:0042221,GO:0042592,GO:0042599,GO:0042742,GO:0043025,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043277,GO:0043299,GO:0043312,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044297,GO:0044344,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045055,GO:0045176,GO:0045177,GO:0045202,GO:0045321,GO:0045335,GO:0045851,GO:0045995,GO:0046474,GO:0046486,GO:0046488,GO:0046903,GO:0046907,GO:0048193,GO:0048471,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051049,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055037,GO:0055038,GO:0055067,GO:0055080,GO:0055082,GO:0060627,GO:0065007,GO:0065008,GO:0070820,GO:0070821,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0071840,GO:0071944,GO:0080171,GO:0090382,GO:0090383,GO:0090386,GO:0090387,GO:0090390,GO:0090407,GO:0097159,GO:0097208,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098771,GO:0098791,GO:0098805,GO:0099503,GO:1901265,GO:1901363,GO:1901576,GO:2000026	-	ko:K07881	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
HKD1_k127_5693289_4	582899.Hden_2462	4.357e-59	213.0	COG1028@1|root,COG1028@2|Bacteria	582899.Hden_2462|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5693289_7	1458357.BG58_21635	1.188e-16	92.0	COG4129@1|root,COG4129@2|Bacteria,1PWSU@1224|Proteobacteria,2WCBG@28216|Betaproteobacteria,1K7GX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Aromatic acid exporter family member 1	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
HKD1_k127_5693289_6	1126627.BAWE01000005_gene5364	1.278e-47	173.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,3JZHN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_5693289_0	1267005.KB911256_gene2041	9.98e-290	895.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3N6GJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_5693289_2	717785.HYPMC_0978	8.274e-137	441.0	COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_5693289_3	717785.HYPMC_0977	1.184e-63	223.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,2U72T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	fdsG	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
HKD1_k127_5693289_1	582899.Hden_2465	3.141e-273	848.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,3N9FU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	fdsB	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_5693289_5	1121033.AUCF01000001_gene2493	7.517e-50	181.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,2JQ15@204441|Rhodospirillales	204441|Rhodospirillales	C	Formate dehydrogenase subunit alpha	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_5760121_2	670292.JH26_06955	3.076e-38	148.0	COG2847@1|root,COG4549@1|root,COG2847@2|Bacteria,COG4549@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,1JRF4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	nuclear export factor GLE1	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	DUF1775,PCuAC
HKD1_k127_5760121_0	460265.Mnod_1944	5.512e-128	424.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2U0AP@28211|Alphaproteobacteria,1JSI5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	aminotransferase class I and II	rkpG	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_5760121_1	670307.HYPDE_28778	1.475e-71	246.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N7R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_7
HKD1_k127_581289_3	663610.JQKO01000005_gene2410	6.131e-59	209.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria,3NBYJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_581289_0	196490.AUEZ01000008_gene5444	1.099e-243	759.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2TSRU@28211|Alphaproteobacteria,3JWX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD1_k127_581289_2	1230476.C207_03679	2.134e-100	332.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2TUAC@28211|Alphaproteobacteria,3JTK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	COG4237 Hydrogenase 4 membrane component (E)	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_581289_1	1122962.AULH01000011_gene1061	9.354e-151	488.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria,36XK6@31993|Methylocystaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase	hycD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD1_k127_581289_4	1500306.JQLA01000003_gene4550	4.701e-47	171.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,4BCA8@82115|Rhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD1_k127_5851878_3	1267005.KB911255_gene2395	1.245e-106	366.0	COG0542@1|root,COG0542@2|Bacteria,1NXPQ@1224|Proteobacteria,2UTUZ@28211|Alphaproteobacteria,3N8QT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	-	-	-	-	-	-	-	-	-	Clp_N
HKD1_k127_5851878_4	582899.Hden_3421	1e-69	242.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,3N6SJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD1_k127_5851878_0	670307.HYPDE_40988	3.208e-236	746.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,3N62W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD1_k127_5851878_5	318586.Pden_0873	2.878e-26	113.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria,2PX96@265|Paracoccus	28211|Alphaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_5851878_6	670307.HYPDE_41003	4.047e-14	73.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,2UJCE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_5851878_2	1267005.KB911255_gene2389	5.707e-183	584.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,3N6QC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	pyridine nucleotide-disulfide oxidoreductase	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5851878_1	1267005.KB911255_gene2388	6.956e-196	624.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,3N670@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_5990241_0	1267005.KB911255_gene2983	4.451e-183	581.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,3N6FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ABC transporter	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_5990241_3	518766.Rmar_0212	3.718e-12	72.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	GGACT
HKD1_k127_5990241_2	1122613.ATUP01000002_gene2436	2.24e-33	134.0	COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2UCNX@28211|Alphaproteobacteria,43YEU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	PFAM Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD1_k127_5990241_1	670307.HYPDE_37853	1.956e-81	274.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,3N6GH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD1_k127_599059_0	670307.HYPDE_37963	7.897e-291	921.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3N655@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
HKD1_k127_599059_5	1267005.KB911255_gene2959	1.189e-88	301.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N8TJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_599059_4	582899.Hden_2881	9.667e-89	299.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3N72B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Thioredoxin	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_599059_6	1267005.KB911255_gene2961	1.669e-40	156.0	COG5389@1|root,COG5389@2|Bacteria,1Q4X3@1224|Proteobacteria,2V6K5@28211|Alphaproteobacteria,3N7GG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD1_k127_599059_3	582899.Hden_2879	4.069e-170	543.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,3N678@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	endonuclease III	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD1_k127_599059_7	1267005.KB911255_gene2532	2.794e-23	114.0	2ED3M@1|root,3370H@2|Bacteria,1NB6I@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HKD1_k127_599059_2	670307.HYPDE_37658	1.434e-174	559.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TTY2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
HKD1_k127_599059_1	670307.HYPDE_37938	1.961e-194	611.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,3N6BS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	ccrM	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_599059_8	1267005.KB911255_gene2966	4.338e-19	87.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,3N6VY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_600642_0	670307.HYPDE_37738	3.832e-307	949.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,3N63K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_600642_1	297246.lpp2473	2.675e-72	255.0	COG0596@1|root,COG0596@2|Bacteria,1N3G3@1224|Proteobacteria,1S50R@1236|Gammaproteobacteria,1JGJE@118969|Legionellales	118969|Legionellales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_600642_4	1298867.AUES01000033_gene2094	6.28e-10	66.0	COG3637@1|root,COG3637@2|Bacteria,1RJPD@1224|Proteobacteria,2UBPQ@28211|Alphaproteobacteria,3JZPR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	CBP_BcsS,OMP_b-brl
HKD1_k127_600642_3	288000.BBta_3979	8.789e-21	98.0	COG3637@1|root,COG3637@2|Bacteria,1N490@1224|Proteobacteria,2TRBY@28211|Alphaproteobacteria,3JTQ4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD1_k127_600642_2	670307.HYPDE_33963	2.326e-48	184.0	COG0810@1|root,COG0810@2|Bacteria,1PVW4@1224|Proteobacteria,2V740@28211|Alphaproteobacteria,3N8Y7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_600642_6	1122132.AQYH01000007_gene1817	0.0005378	48.0	COG3637@1|root,COG3637@2|Bacteria,1RKNU@1224|Proteobacteria,2UBCN@28211|Alphaproteobacteria,4BH7Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	OmpA-like transmembrane domain	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD1_k127_600642_5	622637.KE124774_gene3441	1.063e-05	51.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,2TUMQ@28211|Alphaproteobacteria,371H3@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
HKD1_k127_6047735_3	717785.HYPMC_2793	1.412e-81	280.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,3N6NF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Molybdopterin binding	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_6047735_2	1267005.KB911259_gene3713	9.468e-107	350.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,2U10V@28211|Alphaproteobacteria,3N8EN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HKD1_k127_6047735_4	582899.Hden_0940	1.02e-68	237.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,3N6ZZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	SelR domain	msrB1	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD1_k127_6047735_1	670307.HYPDE_36663	1.054e-121	398.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2TSG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	serves to protect cells from the toxic effects of hydrogen peroxide	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase
HKD1_k127_6047735_0	1038859.AXAU01000001_gene3801	6.159e-200	633.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,3JTX3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Retinal pigment epithelial membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	RPE65
HKD1_k127_6047735_5	1040989.AWZU01000083_gene1215	6.326e-33	128.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,2U9WX@28211|Alphaproteobacteria,3JYRP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD1_k127_6056768_4	670307.HYPDE_27863	3.46e-43	168.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_6056768_0	196367.JNFG01000202_gene2635	1.579e-182	604.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VM6A@28216|Betaproteobacteria,1K3IC@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LuxR family transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
HKD1_k127_6056768_2	717785.HYPMC_0784	1.753e-72	254.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,2TSGQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_05800	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD1_k127_6056768_1	1125973.JNLC01000013_gene4087	2.868e-98	329.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,3JTEJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_6056768_3	717785.HYPMC_3776	3.206e-72	248.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Nad-dependent epimerase dehydratase	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD1_k127_6062251_2	670307.HYPDE_28433	9.672e-28	113.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,3N71T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	molybdopterin biosynthesis MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HKD1_k127_6062251_0	1267005.KB911255_gene3037	2.642e-141	461.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,3N6RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD1_k127_6062251_1	1267005.KB911262_gene3367	2.072e-92	306.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,3N6J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD1_k127_6066845_1	717785.HYPMC_2996	4.744e-78	264.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,3N6J0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD1_k127_6066845_0	670307.HYPDE_28408	1.609e-122	402.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,3N6IA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_6079436_4	460265.Mnod_6519	4.802e-100	330.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,1JTBD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_6079436_10	1535287.JP74_16240	2.814e-25	107.0	COG2261@1|root,COG2261@2|Bacteria,1N6QR@1224|Proteobacteria,2UFTV@28211|Alphaproteobacteria,3N9DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_6079436_3	443598.AUFA01000044_gene4759	5.994e-133	431.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,3JQSF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD1_k127_6079436_8	359.CN09_07775	1.04e-52	190.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,4BE29@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
HKD1_k127_6079436_7	1267005.KB911263_gene1297	3.786e-73	263.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,2U1FV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD1_k127_6079436_9	1336243.JAEA01000013_gene3262	8.478e-51	185.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,1JV1N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD1_k127_6079436_6	717785.HYPMC_2079	2.133e-79	269.0	COG1846@1|root,COG1846@2|Bacteria,1PJHM@1224|Proteobacteria,2VAEP@28211|Alphaproteobacteria,3N7DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_6079436_1	1267005.KB911263_gene1294	5.541e-152	490.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,3N6G2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD1_k127_6079436_2	1267005.KB911263_gene1293	2.745e-139	451.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,3N67V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_6079436_0	1267005.KB911263_gene1292	2.757e-180	576.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,3N6I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phospho-acceptor) domain	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_6079436_5	1267005.KB911263_gene1291	1.539e-86	287.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N69C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
HKD1_k127_6083170_13	1267005.KB911265_gene3583	1.659e-39	152.0	COG4530@1|root,COG4530@2|Bacteria,1N85Z@1224|Proteobacteria,2UF7V@28211|Alphaproteobacteria,3N7E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (FYDLN_acid)	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
HKD1_k127_6083170_4	670307.HYPDE_34623	2.389e-196	625.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3N68X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_6083170_8	1267005.KB911265_gene3585	8.205e-79	268.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,3N6X9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD1_k127_6083170_1	1267005.KB911265_gene3586	1e-323	996.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,3N68W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD1_k127_6083170_7	717785.HYPMC_0541	1.621e-121	398.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,3N6TC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD1_k127_6083170_11	582899.Hden_2323	1.262e-43	167.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,3N73M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_6083170_12	1267005.KB911265_gene3589	3.389e-40	151.0	COG5416@1|root,COG5416@2|Bacteria,1PKR5@1224|Proteobacteria,2UZCM@28211|Alphaproteobacteria,3N7EI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
HKD1_k127_6083170_9	717785.HYPMC_0544	5.077e-69	242.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,3N70F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD1_k127_6083170_2	1267005.KB911265_gene3591	4.712e-241	749.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,3N61T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6083170_6	1267005.KB911265_gene3592	6.693e-122	397.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,3N6A2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD1_k127_6083170_5	670307.HYPDE_34558	4.15e-161	516.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,3N6AB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_6083170_3	1267005.KB911265_gene3594	2.7e-206	649.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,3N6CW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HKD1_k127_6083170_10	717785.HYPMC_0553	4.336e-51	183.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,3N718@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_6083170_0	1267005.KB911265_gene3596	0.0	1236.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_6091730_2	1267005.KB911259_gene3868	2.468e-88	295.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,3N6HX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_6091730_1	670307.HYPDE_35678	1.088e-90	316.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,3N6ZQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
HKD1_k127_6091730_3	582899.Hden_2418	9.672e-88	302.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,3N77B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD1_k127_6091730_6	1267005.KB911259_gene3871	1.867e-35	153.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K02067,ko:K03286,ko:K03640	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	1.B.6,2.C.1.2,3.A.1.27	-	-	NMT1,OmpA
HKD1_k127_6091730_4	582899.Hden_2420	3.183e-70	241.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,3N70J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_6091730_0	1267005.KB911259_gene3875	1.839e-227	712.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,3N6E0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD1_k127_6091730_5	1267005.KB911259_gene3876	2.325e-67	236.0	COG3170@1|root,COG3170@2|Bacteria,1QW53@1224|Proteobacteria,2U4DN@28211|Alphaproteobacteria,3N9IN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	NU	TIGRFAM protein TolA	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
HKD1_k127_6093540_11	1101191.KI912577_gene608	9.486e-27	111.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,1JRBH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	4Fe-4S double cluster binding domain	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
HKD1_k127_6093540_6	1267005.KB911255_gene2467	1.22e-102	346.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria,3N6ME@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_6093540_8	1267005.KB911255_gene2466	1.077e-47	193.0	COG3064@1|root,COG3064@2|Bacteria,1R7WR@1224|Proteobacteria	1224|Proteobacteria	M	Membrane	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	DUF874,TonB_2
HKD1_k127_6093540_3	1267005.KB911255_gene2537	1.545e-130	431.0	2C20F@1|root,32R9J@2|Bacteria,1RKQ3@1224|Proteobacteria	1224|Proteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
HKD1_k127_6093540_7	1089551.KE386572_gene1017	1.226e-58	209.0	COG1278@1|root,COG1278@2|Bacteria,1PVQB@1224|Proteobacteria,2VBJA@28211|Alphaproteobacteria,4BT3K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
HKD1_k127_6093540_9	314230.DSM3645_22966	8.736e-45	168.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
HKD1_k127_6093540_5	582899.Hden_0389	2.271e-104	346.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,3N6T9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_24420	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
HKD1_k127_6093540_2	1267005.KB911255_gene2461	2.711e-147	477.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,2TSPN@28211|Alphaproteobacteria,3N859@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like	capM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_6093540_4	648757.Rvan_1982	2.665e-105	351.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,2TQZ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD1_k127_6093540_1	670307.HYPDE_36893	7.732e-157	507.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,3N7KH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	lytic murein transglycosylase	MA20_01345	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,SLT_2
HKD1_k127_6093540_10	670307.HYPDE_36348	1.434e-41	167.0	2DRBB@1|root,33B2T@2|Bacteria,1R1G2@1224|Proteobacteria,2TZ1F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4236
HKD1_k127_6093540_0	670307.HYPDE_36353	1.009e-234	732.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,3N69G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD1_k127_6144846_13	717785.HYPMC_2896	1.706e-43	167.0	COG4891@1|root,COG4891@2|Bacteria,1N4U1@1224|Proteobacteria,2UGHM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_6144846_2	1267005.KB911260_gene3566	3.571e-236	734.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,3N65X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_6144846_15	1267005.KB911260_gene3563	5.125e-32	129.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD1_k127_6144846_16	404589.Anae109_3233	2.056e-19	96.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,42TER@68525|delta/epsilon subdivisions,2WPKW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD1_k127_6144846_9	1267005.KB911260_gene3561	1.315e-97	321.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,3N6N7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_6144846_8	1267005.KB911260_gene3560	1.905e-104	347.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,3N6IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_6144846_12	59538.XP_005973860.1	3.34e-50	182.0	COG0838@1|root,KOG4662@2759|Eukaryota,3A8AU@33154|Opisthokonta	33154|Opisthokonta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	nad3	-	1.6.5.3	ko:K03880	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q4
HKD1_k127_6144846_20	1218075.BAYA01000054_gene6903	0.0002916	46.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2VS54@28216|Betaproteobacteria,1K3QS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HKD1_k127_6144846_11	215803.DB30_4528	3.115e-54	199.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,43B1P@68525|delta/epsilon subdivisions,2X6FU@28221|Deltaproteobacteria,2YUYE@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HKD1_k127_6144846_14	1267005.KB911260_gene3555	2.097e-40	151.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N7A9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_6144846_0	1267005.KB911260_gene3554	0.0	1386.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,3N6J9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_6144846_1	1267005.KB911260_gene3553	6.154e-257	795.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,3N66W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_6144846_6	670307.HYPDE_28738	5.89e-121	390.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,3N6HZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_6144846_3	1267005.KB911260_gene3551	9.508e-176	563.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,3N67G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_6144846_4	316057.RPD_2564	1.924e-159	513.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,3JRM9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6144846_5	1267005.KB911260_gene3546	6.111e-144	462.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,3N6EB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_6144846_7	1411123.JQNH01000001_gene838	2.758e-110	368.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_4,PAS_7
HKD1_k127_6144846_10	1038859.AXAU01000012_gene4374	1.436e-64	229.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JTV0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,EAL,GGDEF,HAMP,PAS_4,PAS_7,PAS_8
HKD1_k127_6155609_1	316056.RPC_2532	4.83e-64	222.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VF0E@28211|Alphaproteobacteria,3JZ5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	peptidyl-prolyl cis-trans isomerase	MA20_44950	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,Rhodanese
HKD1_k127_6155609_5	864069.MicloDRAFT_00035400	1.509e-06	59.0	COG3631@1|root,COG3631@2|Bacteria,1RGPW@1224|Proteobacteria,2U7SR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HKD1_k127_6155609_0	717785.HYPMC_0878	0.0	1150.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3N69N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD1_k127_6166474_5	1267005.KB911261_gene2185	5.33e-101	331.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,3N818@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_6166474_0	670307.HYPDE_37233	2.281e-230	718.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,3N66J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_6166474_11	1267005.KB911258_gene459	1.987e-22	98.0	2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6166474_10	1267005.KB911265_gene3650	9.948e-50	184.0	2CN5Z@1|root,32SGB@2|Bacteria,1N1FB@1224|Proteobacteria,2UBV1@28211|Alphaproteobacteria,3N754@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2948)	MA20_21100	-	-	-	-	-	-	-	-	-	-	-	DUF2948
HKD1_k127_6166474_1	670307.HYPDE_37223	1.724e-199	632.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,3N658@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_6166474_7	1380355.JNIJ01000010_gene1451	4.912e-63	226.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria,3JTW9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0262 family	MA20_21090	-	-	-	-	-	-	-	-	-	-	-	UPF0262
HKD1_k127_6166474_9	648757.Rvan_3544	5.516e-56	200.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,3N8V5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Low molecular weight phosphatase family	MA20_21085	-	1.20.4.1,3.1.3.48	ko:K01104,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_6166474_3	1267005.KB911265_gene3654	8.536e-140	458.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
HKD1_k127_6166474_6	1267005.KB911265_gene3655	9.347e-95	316.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_6166474_4	1267005.KB911257_gene638	8.784e-109	357.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,3N6Q6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD1_k127_6166474_12	582899.Hden_2708	1.651e-14	79.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2UJJF@28211|Alphaproteobacteria,3N7DQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD1_k127_6166474_2	1038859.AXAU01000001_gene3420	3.863e-176	559.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2TSB9@28211|Alphaproteobacteria,3K6SH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_6166474_13	1197906.CAJQ02000003_gene3219	1.815e-07	53.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_6166474_8	1562701.BBOF01000078_gene147	1.619e-62	218.0	COG4974@1|root,COG4974@2|Bacteria,1QV9T@1224|Proteobacteria,2W3XN@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_6175488_11	582899.Hden_2003	3.018e-98	325.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,3N67A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	MA20_15735	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_6175488_0	717785.HYPMC_2978	0.0	1275.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3N6KF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_6175488_10	582899.Hden_2000	1.428e-100	347.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,3N6IM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_6175488_2	717785.HYPMC_2975	3.152e-200	641.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,3N6DC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_6175488_3	1267005.KB911255_gene3013	5.104e-175	554.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,3N636@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD1_k127_6175488_5	1267005.KB911255_gene3012	1.389e-166	530.0	COG4111@1|root,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,2TQQU@28211|Alphaproteobacteria,3N7IW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	belongs to the nudix hydrolase family	MA20_42130	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6175488_16	1267005.KB911255_gene3011	2.698e-76	261.0	COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria,3N6SK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	MA20_42120	-	-	ko:K06952	-	-	-	-	ko00000	-	-	-	HD,HD_3
HKD1_k127_6175488_14	717785.HYPMC_2971	7.479e-81	279.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,3N6ZF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD1_k127_6175488_13	1267005.KB911255_gene3009	1.955e-89	310.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,3N6WQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD1_k127_6175488_1	717785.HYPMC_2969	6.761e-233	732.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,3N66I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC1	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_6175488_17	717785.HYPMC_2968	4.329e-63	227.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2TUXV@28211|Alphaproteobacteria,3N74N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_6175488_19	1267005.KB911255_gene3006	2.258e-54	198.0	2BVJQ@1|root,32QXM@2|Bacteria,1RAQH@1224|Proteobacteria,2VGWW@28211|Alphaproteobacteria,3N9I9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6175488_12	1267005.KB911255_gene3005	2.199e-91	304.0	COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2UCZW@28211|Alphaproteobacteria,3N8KX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD1_k127_6175488_22	1267005.KB911255_gene3004	5.865e-25	107.0	2E7H7@1|root,33EKK@2|Bacteria,1NIUX@1224|Proteobacteria,2UJWB@28211|Alphaproteobacteria,3N7EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6175488_20	582899.Hden_1988	2.192e-46	170.0	COG5451@1|root,COG5451@2|Bacteria,1MYIV@1224|Proteobacteria,2UGCX@28211|Alphaproteobacteria,3N7DK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2385)	MA20_42075	-	-	-	-	-	-	-	-	-	-	-	DUF2385
HKD1_k127_6175488_15	717785.HYPMC_2963	8.951e-78	267.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,3N6WV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD1_k127_6175488_4	717785.HYPMC_4514	3.709e-171	554.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,3N6DU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_42035	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_6175488_9	1267005.KB911256_gene1651	1.045e-115	382.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,3N622@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_6175488_25	1550073.JROH01000044_gene3144	4.968e-05	51.0	2A1RN@1|root,30Q08@2|Bacteria,1Q4TQ@1224|Proteobacteria,2UXZ7@28211|Alphaproteobacteria,2KBQ3@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1902)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1902
HKD1_k127_6175488_7	1267005.KB911256_gene1653	4.979e-143	469.0	2E6Z4@1|root,331IA@2|Bacteria,1NFY1@1224|Proteobacteria,2UHSC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6175488_8	582899.Hden_1980	8.698e-132	426.0	COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,2TTJC@28211|Alphaproteobacteria,3N844@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	ko:K13775	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short,adh_short_C2
HKD1_k127_6175488_6	1267005.KB911256_gene1654	1.832e-150	480.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,3N6CA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
HKD1_k127_6175488_21	1267005.KB911256_gene1655	1.895e-36	139.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,3N773@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_6175488_24	196490.AUEZ01000055_gene235	1.911e-16	79.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6175488_18	582899.Hden_0486	3.413e-57	200.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,3N64P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_6217942_2	1304878.AUGD01000001_gene195	3.881e-180	568.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110
HKD1_k127_6217942_1	717785.HYPMC_2194	2.279e-203	641.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2U1A0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD1_k127_6217942_0	717785.HYPMC_2195	5.088e-210	659.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TUX3@28211|Alphaproteobacteria,3N645@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_6225424_1	717785.HYPMC_2405	1.841e-170	545.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3N61H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	penicillin-binding protein	pbp	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_6225424_4	1267005.KB911258_gene362	1.273e-69	245.0	COG5402@1|root,COG5402@2|Bacteria,1N26C@1224|Proteobacteria,2TT9K@28211|Alphaproteobacteria,3N79F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	MA20_15585	-	-	-	-	-	-	-	-	-	-	-	DUF1214
HKD1_k127_6225424_9	1267005.KB911258_gene361	5.816e-38	157.0	COG5436@1|root,COG5436@2|Bacteria,1PJY8@1224|Proteobacteria,2VCV8@28211|Alphaproteobacteria,3N7FH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6225424_8	717785.HYPMC_2402	2.471e-40	152.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria,3N7DI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1491)	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
HKD1_k127_6225424_11	670307.HYPDE_32173	4.051e-33	138.0	COG3409@1|root,COG3409@2|Bacteria,1RHI5@1224|Proteobacteria,2V62Q@28211|Alphaproteobacteria,3N9CZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_6225424_7	717785.HYPMC_2399	2.245e-51	189.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,3N71M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
HKD1_k127_6225424_2	929556.Solca_0753	6.08e-132	424.0	COG0500@1|root,COG2226@2|Bacteria,4NFRD@976|Bacteroidetes,1IVKT@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_6225424_6	582899.Hden_1095	4.832e-59	210.0	COG0583@1|root,COG0583@2|Bacteria,1MXC9@1224|Proteobacteria,2TTTY@28211|Alphaproteobacteria,3N7GR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6225424_10	1267005.KB911258_gene354	3.274e-35	139.0	COG0593@1|root,COG0593@2|Bacteria,1N76V@1224|Proteobacteria,2UG3R@28211|Alphaproteobacteria,3N7FJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Bacterial dnaA protein helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C
HKD1_k127_6225424_5	1267005.KB911258_gene353	6.472e-68	234.0	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,3N700@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	mucR	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
HKD1_k127_6225424_0	1267005.KB911258_gene352	0.0	1148.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,3N62G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD1_k127_6225424_3	582899.Hden_1602	9.664e-101	330.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2U93B@28211|Alphaproteobacteria,3N8I4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_623609_6	1267005.KB911255_gene2941	6.712e-90	299.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,3N6Z7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD1_k127_623609_0	1267005.KB911255_gene2940	0.0	1442.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N644@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	MA20_18100	-	3.1.4.52	ko:K13245	ko04112,map04112	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3
HKD1_k127_623609_7	1267005.KB911255_gene2939	6.235e-78	265.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,3N6Y2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_623609_3	1267005.KB911255_gene2938	1.541e-163	527.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,3N6HA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	mpp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_623609_1	1267005.KB911255_gene2937	2.379e-209	660.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,3N6DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Threonine synthase	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_623609_8	1267005.KB911255_gene2936	3.725e-70	245.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,3N7AI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	SURF1 family	surf1	GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
HKD1_k127_623609_10	1267005.KB911255_gene2935	3.009e-41	160.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,3N92J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HKD1_k127_623609_4	1267005.KB911255_gene2934	8.678e-153	488.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,3N64R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_623609_9	1408224.SAMCCGM7_c0984	1.042e-61	218.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,4BA7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD1_k127_623609_5	717785.HYPMC_4184	3.76e-139	447.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,3N6K8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD1_k127_623609_2	1267005.KB911255_gene2930	3.218e-209	652.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_6244178_0	670307.HYPDE_39218	8.132e-293	914.0	COG0791@1|root,COG0791@2|Bacteria,1MU8A@1224|Proteobacteria,2U1XU@28211|Alphaproteobacteria,3N8B1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6244178_1	7213.XP_004528140.1	1.14e-25	108.0	COG0621@1|root,KOG2492@2759|Eukaryota,38E0X@33154|Opisthokonta,3BEN9@33208|Metazoa,3CXYH@33213|Bilateria,41VD1@6656|Arthropoda,3SHRU@50557|Insecta,44YE5@7147|Diptera	33208|Metazoa	T	4 iron, 4 sulfur cluster binding. It is involved in the biological process described with RNA modification	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,UPF0004
HKD1_k127_6267580_1	1267005.KB911258_gene438	4.683e-121	399.0	COG5653@1|root,COG5653@2|Bacteria,1N2SG@1224|Proteobacteria,2UCEG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_6267580_0	1267005.KB911263_gene1273	1.53e-171	543.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2TSKU@28211|Alphaproteobacteria,3N6H2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Ferredoxin--NADP reductase	MA20_08170	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD1_k127_6267580_2	670307.HYPDE_30043	1.607e-50	182.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,3N745@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	ferredoxin	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD1_k127_6267580_3	717785.HYPMC_1911	1.446e-24	110.0	COG2198@1|root,COG2198@2|Bacteria,1RI91@1224|Proteobacteria,2UGE0@28211|Alphaproteobacteria,3N7GC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
HKD1_k127_63123_3	717785.HYPMC_1089	6.963e-33	133.0	COG2982@1|root,COG2982@2|Bacteria,1QWQT@1224|Proteobacteria,2TX2D@28211|Alphaproteobacteria,3N6W2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HKD1_k127_63123_0	717785.HYPMC_1088	2.259e-69	242.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,3N75C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_63123_1	1267005.KB911256_gene1990	8.623e-53	190.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,3N8U2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_63123_2	492774.JQMB01000001_gene5681	4.846e-40	161.0	COG0419@1|root,COG0419@2|Bacteria,1MXMI@1224|Proteobacteria,2TU9I@28211|Alphaproteobacteria,4B9VV@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
HKD1_k127_6415262_2	1502851.FG93_03954	4.195e-152	489.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JQQ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
HKD1_k127_6415262_3	426355.Mrad2831_2251	4.66e-117	401.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,1JRX6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM ABC transporter	braF	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	3.5.4.44	ko:K01995,ko:K15783	ko00260,ko01100,ko02010,ko02024,map00260,map01100,map02010,map02024	M00237	R09800	RC02661	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6415262_4	1510531.JQJJ01000008_gene3409	7.339e-109	357.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JUTM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_6415262_6	426355.Mrad2831_2253	1.064e-24	109.0	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,1JV69@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6415262_1	1267005.KB911258_gene502	1.702e-165	528.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3N79P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6415262_5	631454.N177_4189	1.322e-55	208.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,1JPS4@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6415262_0	1267005.KB911258_gene500	1.149e-234	730.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,3N6DZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD1_k127_6415262_8	1095743.HMPREF1054_1267	7.223e-15	80.0	COG1525@1|root,COG1525@2|Bacteria,1NNMW@1224|Proteobacteria,1T2SY@1236|Gammaproteobacteria,1YAZN@135625|Pasteurellales	135625|Pasteurellales	L	Excalibur calcium-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur
HKD1_k127_6415262_7	1197906.CAJQ02000009_gene3591	2.217e-23	114.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,3JST3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_6458859_4	460265.Mnod_3107	5.965e-25	104.0	COG1695@1|root,COG1695@2|Bacteria,1RHG3@1224|Proteobacteria,2UEEJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD1_k127_6458859_2	194867.ALBQ01000053_gene1881	1.403e-55	199.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_6458859_0	670307.HYPDE_23533	4.997e-265	822.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Multi-copper	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_6458859_1	443598.AUFA01000010_gene375	4.31e-189	599.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3JSVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_6458859_3	670307.HYPDE_35983	1.198e-34	135.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2U9XS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_6458859_7	1122179.KB890480_gene3150	1.68e-05	51.0	295U4@1|root,2ZT58@2|Bacteria,4PQ2P@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_6458859_5	314345.SPV1_10546	1.724e-18	91.0	2CAA3@1|root,2ZJET@2|Bacteria,1NZG0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6535927_10	670307.HYPDE_32658	1.974e-91	303.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,3N6AX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_6535927_8	717785.HYPMC_2574	3.349e-100	331.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,3N6MM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_6535927_26	670307.HYPDE_32648	9.201e-30	131.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,3N759@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_6535927_4	1267005.KB911261_gene2238	1.921e-154	490.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,3N6HR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_6535927_22	717785.HYPMC_2571	3.183e-49	179.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,3N73I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD1_k127_6535927_20	1267005.KB911261_gene2236	3.77e-55	198.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,3N6XQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD1_k127_6535927_5	582899.Hden_1023	2.616e-121	402.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,3N6KN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD1_k127_6535927_14	1267005.KB911261_gene2234	3.814e-73	247.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,3N6UX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_6535927_28	1187851.A33M_2375	5.552e-17	83.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,3FDGV@34008|Rhodovulum	28211|Alphaproteobacteria	J	Ribosomal L29 protein	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD1_k127_6535927_25	1267005.KB911261_gene2232	1.38e-34	133.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,3N78R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD1_k127_6535927_17	1267005.KB911261_gene2231	6.729e-68	235.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,3N6TX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_6535927_21	1267005.KB911261_gene2230	1.482e-51	186.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,3N73B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD1_k127_6535927_7	717785.HYPMC_2563	2.334e-100	332.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,3N6HT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_6535927_23	1267005.KB911261_gene2228	6.952e-48	172.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,3N73V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_6535927_16	1267005.KB911261_gene2227	1.16e-69	237.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,3N6Y3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD1_k127_6535927_11	1267005.KB911261_gene2226	1.221e-87	291.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,3N6UR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_6535927_24	1267005.KB911261_gene2225	3.903e-47	171.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,3N6ZG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD1_k127_6535927_9	582899.Hden_1034	6.625e-98	322.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,3N6DJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_6535927_27	376733.IT41_04365	6.695e-20	91.0	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2PXS0@265|Paracoccus	28211|Alphaproteobacteria	J	Ribosomal protein L30p/L7e	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD1_k127_6535927_13	670307.HYPDE_32563	6.814e-78	265.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,3N6ZC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD1_k127_6535927_0	1267005.KB911261_gene2221	4.195e-242	754.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,3N6EX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_6535927_12	1042326.AZNV01000012_gene1816	8.326e-84	292.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,4B8J5@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD1_k127_6535927_19	670307.HYPDE_32548	1.776e-61	218.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,3N6UW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_6535927_15	582899.Hden_1040	2.28e-70	239.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2U717@28211|Alphaproteobacteria,3N6U0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_6535927_2	1267005.KB911261_gene2217	2.264e-205	640.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,3N68P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_6535927_18	1267005.KB911261_gene2216	1.089e-67	232.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,3N6TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD1_k127_6535927_6	670307.HYPDE_32518	7.988e-110	365.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,3N6NZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	Male sterility protein	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD1_k127_6535927_3	717785.HYPMC_2546	2.605e-193	614.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,3N6F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	htrA2	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_6535927_1	1267005.KB911258_gene88	4.497e-216	676.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,3N63R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_6564622_2	670307.HYPDE_34123	1.031e-70	243.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3N62A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain ATP-binding	pccA	GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_6564622_3	1463917.JODC01000011_gene4731	1.466e-49	179.0	COG0251@1|root,COG0454@1|root,COG0251@2|Bacteria,COG0456@2|Bacteria,2IIB2@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_6564622_4	1267005.KB911259_gene3827	1.392e-23	102.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,3N957@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Acylphosphatase	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD1_k127_6564622_0	1267005.KB911259_gene3826	2.078e-138	444.0	COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,2U1U3@28211|Alphaproteobacteria,3N8K9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_6564622_1	420324.KI911948_gene9268	5.613e-86	291.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,1JTNC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD1_k127_6564622_6	1408427.JADB01000003_gene1273	1.857e-05	47.0	2AE9K@1|root,3143S@2|Bacteria,1PTGX@1224|Proteobacteria,2V5CG@28211|Alphaproteobacteria,48UFM@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_657579_1	1267005.KB911255_gene2539	2.884e-135	437.0	COG1633@1|root,COG1633@2|Bacteria,1MUET@1224|Proteobacteria,2TQMZ@28211|Alphaproteobacteria,3N65F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rubrerythrin	mbfA	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
HKD1_k127_657579_0	1267005.KB911255_gene2538	5.504e-171	548.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,3N88X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Lytic murein transglycosylase	MA20_44755	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
HKD1_k127_657579_2	1380355.JNIJ01000041_gene5231	8.489e-47	169.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3JTS4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6584876_1	582899.Hden_2752	4.671e-170	539.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,3N6EV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD1_k127_6584876_8	1267005.KB911255_gene2419	1.783e-39	151.0	COG0784@1|root,COG0784@2|Bacteria,1QU26@1224|Proteobacteria,2TYX7@28211|Alphaproteobacteria,3N8GF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_6584876_6	717785.HYPMC_4061	2.439e-80	271.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,3N8ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD1_k127_6584876_2	1267005.KB911255_gene2421	1.803e-125	403.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,3N68B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD1_k127_6584876_3	1267005.KB911255_gene2422	1.58e-119	394.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,3N6YI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Cell division protein	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
HKD1_k127_6584876_7	717785.HYPMC_4064	4.458e-59	212.0	COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,3N8WC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	DUF218 domain	MA20_20455	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_6584876_4	1267005.KB911255_gene2424	1.197e-98	328.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,3N6WY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_6584876_0	1267005.KB911255_gene2425	0.0	1102.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,3N888@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD1_k127_669868_9	1267005.KB911255_gene2967	6.522e-79	266.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3N6ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_669868_14	717785.HYPMC_4151	5.43e-68	243.0	COG1216@1|root,COG1216@2|Bacteria,1N6DH@1224|Proteobacteria,2TWBP@28211|Alphaproteobacteria,3N8ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_669868_11	582899.Hden_2874	2.459e-74	261.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,3N6R5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD1_k127_669868_8	1267005.KB911255_gene2970	1.528e-104	350.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,3N6QU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Phage SPO1 DNA	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_669868_1	717785.HYPMC_4148	5.285e-303	935.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,3N6AK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
HKD1_k127_669868_2	582899.Hden_2870	5.245e-218	692.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,3N6J8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Tetratricopeptide repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_669868_12	1267005.KB911255_gene2973	1.683e-71	253.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,3N6X5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_669868_4	717785.HYPMC_4145	1.389e-166	530.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,3N66R@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_669868_18	1121106.JQKB01000009_gene135	5.501e-12	69.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,2JTZQ@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD1_k127_669868_10	582899.Hden_2866	8.119e-76	265.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,2TUBR@28211|Alphaproteobacteria,3N6VC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS
HKD1_k127_669868_7	717785.HYPMC_4142	4.49e-122	397.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TQZP@28211|Alphaproteobacteria,3N6QM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	OU	Peptidase S49	sohB	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD1_k127_669868_13	670307.HYPDE_31923	1.327e-70	244.0	COG1309@1|root,COG1309@2|Bacteria,1RI6S@1224|Proteobacteria,2VFKQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_669868_3	1267005.KB911259_gene4035	3.082e-172	548.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_669868_0	1267005.KB911259_gene4034	0.0	1729.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_669868_6	366602.Caul_0691	1.208e-136	446.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2KK7G@204458|Caulobacterales	204458|Caulobacterales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_669868_16	1380394.JADL01000002_gene1300	1.134e-45	179.0	COG2355@1|root,COG2355@2|Bacteria,1RG53@1224|Proteobacteria,2UE31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_669868_15	1156844.KB891849_gene3308	7.386e-65	232.0	COG2173@1|root,COG2173@2|Bacteria,2GK5P@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
HKD1_k127_6831577_2	1207063.P24_12986	9.398e-60	219.0	COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria,2JS6G@204441|Rhodospirillales	204441|Rhodospirillales	HP	ATP-binding protein	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_6831577_0	1294273.roselon_01003	6.053e-107	362.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_6831577_3	414684.RC1_0664	9.725e-47	180.0	COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,2JSZ7@204441|Rhodospirillales	204441|Rhodospirillales	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_6831577_1	1267005.KB911255_gene2830	1.035e-65	239.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_6831577_4	1267005.KB911255_gene2830	3.769e-31	129.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_6831577_5	1267005.KB911255_gene2830	3.028e-15	81.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_6831577_6	1267005.KB911255_gene2830	3.992e-15	76.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_6864665_3	1267005.KB911258_gene337	5.552e-70	251.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,3N7CG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_6864665_2	1267005.KB911258_gene336	2.565e-93	330.0	28NPA@1|root,2ZBP8@2|Bacteria,1R9WM@1224|Proteobacteria,2U197@28211|Alphaproteobacteria,3N6XT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6864665_1	717785.HYPMC_2426	1.038e-121	400.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,3N64W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
HKD1_k127_6864665_0	670307.HYPDE_32268	9.95e-176	561.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,3N67U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	cystathionine beta-lyase	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_6864665_4	62928.azo1335	2.936e-27	113.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,2KV4D@206389|Rhodocyclales	206389|Rhodocyclales	P	Sulfate ABC transporter inner membrane subunit CysT	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD1_k127_6874833_10	113395.AXAI01000012_gene7133	3.66e-24	109.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,2U9WX@28211|Alphaproteobacteria,3JYRP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD1_k127_6874833_7	1187851.A33M_0545	5.22e-49	179.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,3FDGR@34008|Rhodovulum	28211|Alphaproteobacteria	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_6874833_0	717785.HYPMC_0972	1.693e-320	995.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,3N7ME@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Elongation factor G, domain IV	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6874833_1	717785.HYPMC_0970	1.168e-216	677.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,3N62Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6874833_3	1267005.KB911259_gene3724	2.175e-86	291.0	COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,2UA74@28211|Alphaproteobacteria,3N8UM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6874833_9	582899.Hden_2344	1.008e-46	169.0	COG0477@1|root,COG2814@2|Bacteria,1N8TD@1224|Proteobacteria,2TTRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6874833_13	634177.GLX_23510	3.975e-13	76.0	COG0477@1|root,COG2814@2|Bacteria,1N8TD@1224|Proteobacteria,2TTRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6874833_8	323098.Nwi_2635	8.416e-49	182.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria,3JZ36@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HKD1_k127_6874833_5	1411123.JQNH01000001_gene3149	5.205e-67	236.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2U9PV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HKD1_k127_6874833_6	717785.HYPMC_2738	5.244e-62	216.0	COG1942@1|root,COG1942@2|Bacteria,1RKUX@1224|Proteobacteria,2U9KZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
HKD1_k127_6874833_4	159450.NH14_25820	6.496e-75	258.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2WFGW@28216|Betaproteobacteria,1K11B@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_6874833_2	1134912.AJTV01000044_gene3421	6.251e-184	594.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XHQ@31993|Methylocystaceae	28211|Alphaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_7,PAS_8,PAS_9
HKD1_k127_6950875_2	717785.HYPMC_3881	7.278e-171	547.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF87	MA20_26515	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
HKD1_k127_6950875_4	670307.HYPDE_23903	8.33e-119	389.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,3N93D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
HKD1_k127_6950875_5	670307.HYPDE_23898	1.795e-101	335.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,3N8BU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_6950875_0	1267005.KB911256_gene1886	7.003e-183	588.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,3N61M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_6950875_7	1267005.KB911256_gene1887	2.721e-16	81.0	COG3242@1|root,COG3242@2|Bacteria,1NGPZ@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	MA20_02305	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HKD1_k127_6950875_3	1267005.KB911256_gene1888	2.067e-136	452.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,3N6TN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_6950875_1	1267005.KB911256_gene1889	1.272e-172	551.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,3N66P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
HKD1_k127_6950875_6	1267005.KB911256_gene1890	1.525e-50	184.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3N72S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD1_k127_7047784_2	1267005.KB911258_gene93	4.565e-73	259.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,3N6VU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP12 chaperone protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
HKD1_k127_7047784_3	717785.HYPMC_2539	9.289e-72	259.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,3N6XE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	ppaX	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_7047784_0	717785.HYPMC_2541	4.164e-162	515.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,3N6H0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_7047784_1	1267005.KB911258_gene89	4.038e-92	304.0	2C1A0@1|root,2ZX64@2|Bacteria	2|Bacteria	S	Type VI secretion system (T6SS), amidase effector protein 4	-	-	-	-	-	-	-	-	-	-	-	-	Tae4
HKD1_k127_7056540_0	670307.HYPDE_22818	1.623e-280	879.0	COG0477@1|root,COG2814@2|Bacteria,1MX2Q@1224|Proteobacteria,2TRNS@28211|Alphaproteobacteria,3N9IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7056540_7	717785.HYPMC_0854	8.075e-42	162.0	COG0492@1|root,COG0664@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,1MVX2@1224|Proteobacteria,2TQN3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	MA20_21135	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
HKD1_k127_7056540_3	420324.KI912082_gene6956	3.789e-175	557.0	COG0492@1|root,COG0664@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,1MVX2@1224|Proteobacteria,2TQN3@28211|Alphaproteobacteria,1JRM0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	MA20_21135	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
HKD1_k127_7056540_5	1267005.KB911266_gene1249	1.66e-150	486.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3N7SF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Methyltransferase	MA20_09135	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD1_k127_7056540_1	1267005.KB911266_gene1248	7.713e-217	681.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,3N7UE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_33
HKD1_k127_7056540_2	402626.Rpic_3897	5.02e-195	618.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_7056540_8	670307.HYPDE_23683	3.018e-33	136.0	COG2343@1|root,COG2343@2|Bacteria,1RHXD@1224|Proteobacteria,2UC5N@28211|Alphaproteobacteria,3N98C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HKD1_k127_7056540_4	663610.JQKO01000002_gene1228	3.01e-160	516.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria,3NAWH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Patatin phospholipase	MA20_17270	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	DUF3734,Patatin
HKD1_k127_7056540_6	178901.AmDm5_1921	4.725e-49	179.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,2JSYH@204441|Rhodospirillales	204441|Rhodospirillales	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
HKD1_k127_7056540_9	1123508.JH636439_gene1934	3.441e-10	64.0	COG3728@1|root,COG3728@2|Bacteria	2|Bacteria	L	DNA packaging	-	-	-	ko:K07474	-	-	-	-	ko00000	-	-	-	Terminase_2
HKD1_k127_7064802_3	1267005.KB911258_gene550	1.067e-47	175.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,3N6DB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
HKD1_k127_7064802_0	1038858.AXBA01000022_gene3598	3.117e-295	919.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,3EYJC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_7064802_1	991905.SL003B_1324	1.183e-92	311.0	COG5501@1|root,COG5501@2|Bacteria,1N29C@1224|Proteobacteria,2TTEZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Secreted protein	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
HKD1_k127_7064802_2	1411123.JQNH01000001_gene2333	2.286e-48	179.0	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2U95I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcription elongation factor	greB	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
HKD1_k127_7064802_5	1267005.KB911258_gene543	6.205e-38	148.0	2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,2UKKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7064802_4	1267005.KB911256_gene1936	3.401e-46	174.0	COG2340@1|root,COG2340@2|Bacteria,1RK26@1224|Proteobacteria,2V7AB@28211|Alphaproteobacteria,3N9BY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_7072090_20	1267005.KB911258_gene405	1.3e-19	88.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,3N8A1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Homocysteine S-methyltransferase	metH	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD1_k127_7072090_0	670307.HYPDE_30828	0.0	1501.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3N661@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD1_k127_7072090_1	648757.Rvan_1921	6.148e-140	451.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,3N6P5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_42175	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7072090_17	582899.Hden_1799	1.474e-37	152.0	COG0454@1|root,COG0456@2|Bacteria,1NCNY@1224|Proteobacteria,2UF7T@28211|Alphaproteobacteria,3N901@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_7072090_5	670307.HYPDE_30813	1.416e-104	352.0	COG0726@1|root,COG0726@2|Bacteria,1R8KN@1224|Proteobacteria,2TSM2@28211|Alphaproteobacteria,3N81S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_7072090_4	717785.HYPMC_2111	7.352e-111	364.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,3N8SM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.1.1.41,4.2.1.17	ko:K01692,ko:K11264	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_7072090_3	582899.Hden_1796	2.931e-136	439.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,3N664@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_7072090_19	1267005.KB911258_gene412	3.361e-22	104.0	2E4B6@1|root,32Z6W@2|Bacteria,1N7QS@1224|Proteobacteria,2UFNH@28211|Alphaproteobacteria,3N7EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3126)	MA20_32250	-	-	-	-	-	-	-	-	-	-	-	DUF3126
HKD1_k127_7072090_6	1267005.KB911258_gene413	3.319e-94	314.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,3N6W8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	MA20_32230	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_7072090_7	717785.HYPMC_2107	2.754e-74	256.0	COG3672@1|root,COG3672@2|Bacteria,1NUXW@1224|Proteobacteria,2TTXC@28211|Alphaproteobacteria,3N75I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HKD1_k127_7072090_15	582899.Hden_1792	1.12e-43	168.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,3N757@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD1_k127_7072090_13	717785.HYPMC_2105	8.41e-47	177.0	COG5388@1|root,COG5388@2|Bacteria,1MXF0@1224|Proteobacteria,2U3WI@28211|Alphaproteobacteria,3N77W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PAS domain	MA20_31625	-	-	-	-	-	-	-	-	-	-	-	PAS_5
HKD1_k127_7072090_9	1267005.KB911258_gene417	4.722e-65	230.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,3N92E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rhomboid family	MA20_31620	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_7072090_10	1267005.KB911258_gene418	1.863e-54	196.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,3N7A3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_7072090_2	670307.HYPDE_30758	1.579e-136	442.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3N6X0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Patatin-like phospholipase	rssA	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_7072090_11	1120792.JAFV01000001_gene370	4.783e-50	182.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,36YRP@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
HKD1_k127_7072090_8	582899.Hden_1786	4.308e-69	242.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,3N6QJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_7072090_12	648757.Rvan_1039	3.419e-48	177.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria,3N6YM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
HKD1_k127_7072090_14	1192034.CAP_8177	4.922e-46	171.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,432KZ@68525|delta/epsilon subdivisions,2WYH1@28221|Deltaproteobacteria,2Z12K@29|Myxococcales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7072090_16	1267005.KB911258_gene422	2.896e-40	158.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria,3N786@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_7072090_18	1267005.KB911258_gene425	3.199e-33	129.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,3N646@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD1_k127_7079185_1	1267005.KB911258_gene129	2.226e-184	584.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,3N701@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Orn DAP Arg decarboxylase 2	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_7079185_2	1367847.JCM7686_0439	6.158e-171	554.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2PW83@265|Paracoccus	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_7079185_7	1267005.KB911258_gene562	1.765e-80	276.0	29P18@1|root,309ZE@2|Bacteria,1RF28@1224|Proteobacteria,2U7EN@28211|Alphaproteobacteria,3N8UY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7079185_4	1429916.X566_18225	4.146e-126	410.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,3JS5I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_7079185_11	1267005.KB911263_gene1382	2.287e-38	149.0	COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,2UDRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	relative of glutathione S-transferase, MAPEG superfamily	-	-	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
HKD1_k127_7079185_6	582899.Hden_1859	1.375e-82	277.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria,3N6RN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD1_k127_7079185_8	420324.KI912060_gene5873	1.586e-75	261.0	COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,2TUHQ@28211|Alphaproteobacteria,1JTUY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM beta-lactamase domain protein	MA20_22080	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_7079185_5	670307.HYPDE_31148	6.313e-87	291.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,3N8BA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD1_k127_7079185_3	1120792.JAFV01000001_gene3142	2.828e-137	454.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria,36XB6@31993|Methylocystaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_25925	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD1_k127_7079185_13	991905.SL003B_2830	4.443e-15	81.0	COG3313@1|root,COG3313@2|Bacteria,1Q96A@1224|Proteobacteria,2VARH@28211|Alphaproteobacteria,4BSY9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1289)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
HKD1_k127_7079185_9	1267005.KB911263_gene1388	4.267e-66	233.0	COG3577@1|root,COG3577@2|Bacteria,1MZCI@1224|Proteobacteria,2U9K2@28211|Alphaproteobacteria,3N7AR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	MA20_25915	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	Asp_protease_2,gag-asp_proteas
HKD1_k127_7079185_10	1267005.KB911263_gene1389	2.344e-55	199.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8N@28211|Alphaproteobacteria,3N8XB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HKD1_k127_7079185_0	1267005.KB911263_gene1390	1.15e-188	591.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,3N7JP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	algC	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_7095838_0	318996.AXAZ01000033_gene6446	1.517e-232	722.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HKD1_k127_7095838_1	318996.AXAZ01000033_gene6447	5.746e-169	534.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,3JVM3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_7124974_7	1298858.AUEL01000002_gene1796	1.6e-24	103.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,43PTH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_7124974_3	670307.HYPDE_26448	5.121e-75	255.0	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	'TIGRFAM RNA polymerase sigma factor, sigma-70 family'	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7124974_1	717785.HYPMC_0464	5.731e-89	304.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_7124974_5	113395.AXAI01000012_gene7133	7.649e-49	176.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,2U9WX@28211|Alphaproteobacteria,3JYRP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD1_k127_7124974_6	1121861.KB899925_gene2536	7.109e-44	165.0	COG0589@1|root,COG0589@2|Bacteria,1N9BR@1224|Proteobacteria	1224|Proteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_7124974_0	1121861.KB899925_gene2537	3.722e-175	558.0	COG0475@1|root,COG0475@2|Bacteria,1R7K4@1224|Proteobacteria,2U29N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_7124974_2	1429916.X566_06865	4.6e-78	271.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,3JRZR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	MA20_18405	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_7124974_4	426117.M446_1645	2.657e-69	244.0	COG1402@1|root,COG1402@2|Bacteria,1R4JB@1224|Proteobacteria,2UA21@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_7148178_0	670307.HYPDE_33628	0.0	1414.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,3N6II@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_7148178_3	1038859.AXAU01000002_gene496	1.845e-178	577.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3JVBN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_7148178_9	631454.N177_0674	2.151e-41	158.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,1JP6K@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
HKD1_k127_7148178_1	1267005.KB911258_gene465	1.316e-241	749.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,3N6AW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_7148178_2	582899.Hden_2120	7.373e-186	590.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,3N6T0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
HKD1_k127_7148178_8	582899.Hden_2119	4.487e-60	222.0	2FC42@1|root,34480@2|Bacteria,1P1IM@1224|Proteobacteria,2UVJU@28211|Alphaproteobacteria,3N8XZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7148178_5	1267005.KB911258_gene468	2.371e-110	362.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,3N643@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_7148178_7	1297569.MESS2_730055	6.563e-67	241.0	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U4IW@28211|Alphaproteobacteria,43J44@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HKD1_k127_7148178_6	113395.AXAI01000019_gene6180	1.225e-87	295.0	COG5588@1|root,COG5588@2|Bacteria,1RGIE@1224|Proteobacteria,2U11D@28211|Alphaproteobacteria,3JWPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD1_k127_7148178_4	1267005.KB911258_gene474	3.199e-130	421.0	COG2995@1|root,COG2995@2|Bacteria,1NGIG@1224|Proteobacteria,2UGUB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HKD1_k127_7152863_0	1267005.KB911256_gene1928	1.145e-181	576.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,3N62U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_7152863_4	717785.HYPMC_1174	5.543e-31	130.0	COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria,3N7B5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD1_k127_7152863_1	1267005.KB911256_gene1929	2.906e-118	385.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,3N74D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD1_k127_7152863_3	1267005.KB911256_gene1930	2.792e-62	220.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,3N6WI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_7152863_2	582899.Hden_2242	3.717e-96	319.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,3N6RK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD1_k127_7161704_2	670307.HYPDE_24643	1.669e-176	559.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,3N6KS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HKD1_k127_7161704_8	1267005.KB911255_gene2575	2.021e-65	231.0	COG3832@1|root,COG3832@2|Bacteria,1REDB@1224|Proteobacteria,2UADQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_7161704_6	717785.HYPMC_0819	6.224e-79	269.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3N8I2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Thioesterase
HKD1_k127_7161704_5	670307.HYPDE_24653	1.318e-103	350.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,3N7V8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	PFAM peptidase U6 penicillin-insensitive murein endopeptidase	mepA	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
HKD1_k127_7161704_4	1267005.KB911255_gene2515	2.189e-110	361.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,3N6AG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_7161704_0	1267005.KB911256_gene2022	7.424e-201	649.0	COG1884@1|root,COG1884@2|Bacteria,1NR2K@1224|Proteobacteria,2TSYT@28211|Alphaproteobacteria,3N7I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	mutA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD1_k127_7161704_1	1120792.JAFV01000001_gene244	2.767e-193	617.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,36XPI@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD1_k127_7161704_13	1267005.KB911259_gene4028	1.312e-29	121.0	COG2010@1|root,COG2010@2|Bacteria,1N8V1@1224|Proteobacteria,2UG8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_7161704_3	582899.Hden_2549	1.275e-110	362.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,3N6IP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_7161704_11	1267005.KB911256_gene2029	3.821e-40	151.0	COG2916@1|root,COG2916@2|Bacteria	2|Bacteria	S	protein dimerization activity	hvrA	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
HKD1_k127_7161704_7	1333998.M2A_2735	4.349e-75	258.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,4BQY1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_7161704_10	1267005.KB911256_gene2030	1.714e-53	192.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,3N72T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_7161704_12	1187851.A33M_2554	2.231e-39	147.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,3FCT0@34008|Rhodovulum	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_7181787_2	316055.RPE_3402	7.367e-97	320.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JR83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7181787_3	258594.RPA2971	2.056e-74	265.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2U5AJ@28211|Alphaproteobacteria,3JW8X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197,6.3.3.3	ko:K01935,ko:K02169	ko00780,ko01100,map00780,map01100	M00123,M00572,M00573,M00577	R03182,R09543	RC00003,RC00460,RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD1_k127_7181787_1	582899.Hden_3194	4.349e-156	501.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TTAK@28211|Alphaproteobacteria,3N7Q8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Aminotransferase class I and II	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_7181787_0	670307.HYPDE_39148	7.518e-164	522.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria,3N87F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_7181787_4	1267005.KB911256_gene1455	4.325e-49	183.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2TV81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD1_k127_7206449_6	391626.OAN307_c26460	5.73e-10	63.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
HKD1_k127_7206449_4	1267005.KB911259_gene3746	3.097e-32	131.0	2C2M3@1|root,316DE@2|Bacteria,1R7TZ@1224|Proteobacteria,2UB1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_16080	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7206449_1	717785.HYPMC_0957	1.393e-97	323.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_7206449_3	582899.Hden_0934	6.52e-52	188.0	COG5472@1|root,COG5472@2|Bacteria,1RI0Q@1224|Proteobacteria,2UA0P@28211|Alphaproteobacteria,3N8Q3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Predicted small integral membrane protein (DUF2165)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2165
HKD1_k127_7206449_0	1267005.KB911256_gene1507	3.977e-107	361.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,3N6ZE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD1_k127_7206449_2	1298867.AUES01000018_gene4155	4.504e-52	193.0	28J0S@1|root,2Z8XX@2|Bacteria,1P9IP@1224|Proteobacteria,2TSZQ@28211|Alphaproteobacteria,3JVZV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7212633_4	582899.Hden_3545	7.624e-117	386.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,3N6PY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_7212633_5	1267005.KB911257_gene721	6.683e-111	366.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,3N6M6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD1_k127_7212633_9	1267005.KB911257_gene753	4.347e-20	92.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,3N782@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_7212633_6	670307.HYPDE_41848	1.015e-57	204.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0607 Rhodanese-related sulfurtransferase	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_7212633_1	670307.HYPDE_22543	1.526e-229	720.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,3N6HS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_7212633_2	1267005.KB911257_gene751	1.147e-185	587.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,3N66H@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_7212633_3	1267005.KB911257_gene750	2.087e-150	485.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,3N6B7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,AAA_23,SMC_N
HKD1_k127_7212633_0	1267005.KB911257_gene749	0.0	1170.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,3N6HN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_7252463_7	648757.Rvan_2916	3.067e-13	76.0	COG0664@1|root,COG0664@2|Bacteria,1PKW5@1224|Proteobacteria,2UZHZ@28211|Alphaproteobacteria,3N9BJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_7252463_3	670307.HYPDE_39873	5.118e-124	404.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,3N6G6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	mtrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_7252463_5	670307.HYPDE_39878	3.066e-57	204.0	COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,2U992@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_7252463_0	1267005.KB911257_gene1046	1.81e-187	595.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,3N71B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_7252463_4	717785.HYPMC_4614	1.175e-61	213.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,3N8IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_7252463_2	582899.Hden_3308	1.981e-133	431.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,3N7I9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA thioesterase	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
HKD1_k127_7252463_1	1267005.KB911257_gene1043	1.907e-149	484.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3N6KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_7252463_6	717785.HYPMC_4617	4.14e-48	176.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,3N75X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD1_k127_7285454_16	1267005.KB911265_gene3596	3.317e-20	92.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,3N6E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_7285454_0	1267005.KB911265_gene3597	0.0	1218.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3N6H7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
HKD1_k127_7285454_8	1267005.KB911265_gene3598	9.838e-106	347.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,3N734@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	JM	Nucleotidyl transferase	MA20_24100	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
HKD1_k127_7285454_4	1267005.KB911265_gene3599	1.048e-179	578.0	COG0802@1|root,COG3178@1|root,COG0802@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,3N772@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
HKD1_k127_7285454_1	717785.HYPMC_0558	3.338e-309	969.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,3N6K0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
HKD1_k127_7285454_2	582899.Hden_2305	2.591e-267	828.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,3N631@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_7285454_14	717785.HYPMC_0562	2.846e-42	158.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,3N7BJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	PTS HPr component phosphorylation site	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD1_k127_7285454_13	1267005.KB911265_gene3603	5.378e-60	210.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,3N6X6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	manX	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HKD1_k127_7285454_15	717785.HYPMC_0564	4.702e-35	141.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_7285454_3	1267005.KB911265_gene3605	1.427e-190	616.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,3N6JH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
HKD1_k127_7285454_6	1267005.KB911265_gene3606	3.336e-140	447.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,3N68C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_7285454_9	1267005.KB911265_gene3607	7.403e-80	275.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,2TV14@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	pyridoxamine 5'-phosphate	MA20_19930	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
HKD1_k127_7285454_12	717785.HYPMC_0570	9.089e-73	250.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,2TTSB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_7285454_7	717785.HYPMC_0571	2.028e-112	385.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,3N8J1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	glycosyl transferase family 39	MA20_30100	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_7285454_10	1267005.KB911265_gene3612	2.455e-76	263.0	COG0526@1|root,COG0526@2|Bacteria,1RDJB@1224|Proteobacteria,2U6H8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_7285454_11	977880.RALTA_A1607	8.426e-76	262.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VRMJ@28216|Betaproteobacteria,1K4DR@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Glutamine amido-transferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_7285454_5	1267005.KB911265_gene3617	7.663e-157	504.0	COG0560@1|root,COG0560@2|Bacteria,1R6HK@1224|Proteobacteria,2TV4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_7386328_4	1267005.KB911265_gene3638	3.311e-115	378.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2U5K8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD1_k127_7386328_7	670307.HYPDE_38153	9.513e-46	175.0	COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria,3N9CY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_7386328_1	1267005.KB911265_gene3640	5.732e-178	563.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3N7KA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7386328_3	717785.HYPMC_4196	4.773e-117	398.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,2VF20@28211|Alphaproteobacteria,3N7WH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7386328_5	1267005.KB911265_gene3642	1.422e-102	345.0	COG1566@1|root,COG1566@2|Bacteria,1R7IY@1224|Proteobacteria,2VFKS@28211|Alphaproteobacteria,3N8CQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_7386328_0	717785.HYPMC_4193	0.0	1504.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N65D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_39335	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_7386328_2	717785.HYPMC_4192	5.338e-133	436.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,3N7I5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_7386328_6	670307.HYPDE_38118	5.665e-76	263.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,2UAVR@28211|Alphaproteobacteria,3N992@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD1_k127_7386328_8	1267005.KB911265_gene3646	2.261e-27	117.0	COG3637@1|root,COG3637@2|Bacteria,1REQH@1224|Proteobacteria,2U73B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cellulose biosynthesis protein BcsS	-	-	-	-	-	-	-	-	-	-	-	-	CBP_BcsS
HKD1_k127_73978_2	582899.Hden_1905	4.579e-127	415.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,3N6R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD1_k127_73978_3	1267005.KB911258_gene617	3.089e-99	348.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,2U4AB@28211|Alphaproteobacteria,3N7B6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HKD1_k127_73978_1	582899.Hden_1907	9.395e-136	438.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,3N688@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_73978_4	1267005.KB911258_gene98	1.756e-88	294.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,3N6VI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_73978_0	670307.HYPDE_29023	3.581e-146	470.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,3N6MI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD1_k127_7398009_1	582899.Hden_0913	7.388e-76	259.0	COG3203@1|root,COG3203@2|Bacteria,1NHZ5@1224|Proteobacteria,2U3IJ@28211|Alphaproteobacteria,3N8FW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HKD1_k127_7398009_0	84531.JMTZ01000023_gene4233	9.329e-200	664.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1X499@135614|Xanthomonadales	1236|Gammaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
HKD1_k127_7405931_6	670307.HYPDE_40178	3.104e-61	213.0	COG0346@1|root,COG0346@2|Bacteria,1RI06@1224|Proteobacteria,2U77N@28211|Alphaproteobacteria,3N8Q6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glyoxalase-like domain	lguL	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_7405931_2	670307.HYPDE_40183	1.164e-116	379.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,3N6BI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_7405931_5	1267005.KB911255_gene2620	1.697e-72	254.0	2BX5R@1|root,34AVN@2|Bacteria,1P2HF@1224|Proteobacteria,2UVQ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7405931_7	582899.Hden_3366	4.631e-57	203.0	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,3N75A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Zincin-like metallopeptidase	MA20_43655	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Zincin_1
HKD1_k127_7405931_4	582899.Hden_3367	1.476e-78	270.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,2U64U@28211|Alphaproteobacteria,3N9ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_7405931_0	1267005.KB911255_gene2618	9.372e-278	856.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,3N6B9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_7405931_1	582899.Hden_3370	1.226e-141	456.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,3N6I8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	MA20_05050	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_7405931_3	1267005.KB911255_gene2616	3.929e-80	275.0	COG3391@1|root,COG3391@2|Bacteria,1RGAJ@1224|Proteobacteria,2U5SB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HKD1_k127_7417837_3	1267005.KB911255_gene2615	4.86e-58	204.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,3N64I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7417837_2	670307.HYPDE_40228	1.033e-190	603.0	COG0477@1|root,COG0477@2|Bacteria,1MVZG@1224|Proteobacteria,2TRS1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	kgtP	-	-	ko:K03761	-	-	-	-	ko00000,ko02000	2.A.1.6.2	-	-	Sugar_tr
HKD1_k127_7417837_0	670307.HYPDE_40018	0.0	1042.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,3N6E1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	GTP-binding protein	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_7417837_4	1267005.KB911257_gene1021	7.561e-19	89.0	2DR1J@1|root,339SA@2|Bacteria,1NI5R@1224|Proteobacteria,2UM1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
HKD1_k127_7417837_1	1267005.KB911257_gene1029	5.993e-209	657.0	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1
HKD1_k127_7451739_5	717785.HYPMC_0753	1.624e-61	219.0	COG0745@1|root,COG0745@2|Bacteria,1QUSA@1224|Proteobacteria,2TW5G@28211|Alphaproteobacteria,3N6Y8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	QU41_05915	-	-	ko:K13589	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_7451739_3	1267005.KB911256_gene1958	7.232e-127	414.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,3N6PW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
HKD1_k127_7451739_4	1267005.KB911256_gene1957	8.761e-100	332.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,3N6SG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	inositol mono-phosphatase	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_7451739_2	1267005.KB911256_gene1956	4.421e-129	419.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,3N6NW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	Alpha beta hydrolase fold	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD1_k127_7451739_6	670307.HYPDE_36863	2.65e-56	203.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,3N6YJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
HKD1_k127_7451739_0	582899.Hden_2652	0.0	2615.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3N6A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_7451739_1	1267005.KB911256_gene1952	1.578e-253	787.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3N6EF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_7456982_5	717785.HYPMC_3050	2.021e-121	396.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,3N6VG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
HKD1_k127_7456982_1	717785.HYPMC_3050	1.836e-238	750.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,3N6VG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
HKD1_k127_7456982_3	717785.HYPMC_3049	2.914e-134	439.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	secretion protein	yhiI	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_7456982_10	1532558.JL39_04440	4.188e-27	111.0	COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,2UHM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ChaB	chaB	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
HKD1_k127_7456982_0	224911.27352915	1.299e-307	959.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria,3JUQU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
HKD1_k127_7456982_11	1336243.JAEA01000002_gene2766	5.9e-24	104.0	2EHHF@1|root,33B9C@2|Bacteria,1N3NN@1224|Proteobacteria,2UC59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7456982_8	663610.JQKO01000007_gene2305	5.944e-47	172.0	COG0517@1|root,COG0517@2|Bacteria,1Q3MP@1224|Proteobacteria,2UB19@28211|Alphaproteobacteria,3NCZY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_7456982_7	1267005.KB911260_gene3396	2.034e-52	196.0	COG5502@1|root,COG5502@2|Bacteria,1NB8V@1224|Proteobacteria,2U9GZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
HKD1_k127_7456982_9	717785.HYPMC_3066	5.533e-33	131.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2TXIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1544 Ribosome-associated protein Y (PSrp-1)	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD1_k127_7456982_2	670307.HYPDE_23018	9.555e-143	457.0	COG4143@1|root,COG4143@2|Bacteria,1R5K8@1224|Proteobacteria,2U08Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7456982_4	864069.MicloDRAFT_00059230	1.253e-128	428.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TRNM@28211|Alphaproteobacteria,1JTZK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_7456982_14	190650.CC_2380	0.0002932	45.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD1_k127_7456982_6	402881.Plav_3003	1.656e-56	204.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2U704@28211|Alphaproteobacteria,1JP3Y@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Ribosomal RNA adenine dimethylase	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_7456982_12	107635.AZUO01000005_gene4221	5.576e-22	97.0	COG1662@1|root,COG1662@2|Bacteria,1MV8R@1224|Proteobacteria,2TURN@28211|Alphaproteobacteria,370MH@31993|Methylocystaceae	28211|Alphaproteobacteria	L	IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,DDE_Tnp_IS240
HKD1_k127_7456982_13	426117.M446_5878	3.532e-09	65.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,1JRXB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	MU	TIGRFAM type I secretion outer membrane protein, TolC family	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_7483484_2	1267005.KB911255_gene2498	1.421e-24	104.0	COG0457@1|root,COG0457@2|Bacteria	1267005.KB911255_gene2498|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7483484_3	1231190.NA8A_21386	6.295e-07	55.0	COG4327@1|root,COG4327@2|Bacteria,1QA0K@1224|Proteobacteria,2VDY4@28211|Alphaproteobacteria,43MG3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
HKD1_k127_7483484_1	1038859.AXAU01000005_gene5108	5.75e-87	309.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,3JT27@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sodium:solute symporter family	yjcG	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD1_k127_7483484_0	1267005.KB911258_gene191	3.699e-167	539.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,3N6E5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD1_k127_7485258_2	717785.HYPMC_2139	1.052e-45	169.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,3N75W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_7485258_1	118166.JH976537_gene676	3.213e-46	173.0	COG4101@1|root,COG4101@2|Bacteria,1G64Q@1117|Cyanobacteria,1HFQH@1150|Oscillatoriales	1117|Cyanobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7485258_0	1267005.KB911258_gene552	8.311e-219	684.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,3N61G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_7487710_0	670307.HYPDE_29998	4.72e-178	565.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,3N68Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_7487710_1	670307.HYPDE_30003	6.441e-111	364.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3N6UN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	cytochrome c biogenesis protein	soxV	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD1_k127_7487710_2	1267005.KB911263_gene1267	2.538e-87	296.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,3N80F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_7490052_5	663610.JQKO01000025_gene252	3.393e-132	427.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_7490052_4	663610.JQKO01000025_gene250	7.945e-164	521.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria,3ND0G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD1_k127_7490052_7	395965.Msil_1853	5.025e-103	346.0	COG2207@1|root,COG2207@2|Bacteria,1RJPK@1224|Proteobacteria,2V7E2@28211|Alphaproteobacteria,3NBNY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
HKD1_k127_7490052_0	1267005.KB911259_gene3813	1.281e-298	926.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3N7VQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	poly(R)-hydroxyalkanoic acid synthase	phbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD1_k127_7490052_1	1267005.KB911259_gene3812	3.416e-231	719.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TRE3@28211|Alphaproteobacteria,3N65G@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Aminotransferase	aatC	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_7490052_2	1267005.KB911259_gene3811	1.23e-188	599.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,3N6EU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	homoserine dehydrogenase	hom	GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD1_k127_7490052_3	582899.Hden_1524	1.051e-164	524.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,3N66Q@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	fructose-1,6-bisphosphatase	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD1_k127_7490052_6	1267005.KB911264_gene3155	4.915e-127	415.0	28HDQ@1|root,2Z7Q9@2|Bacteria,1R41M@1224|Proteobacteria,2TTYR@28211|Alphaproteobacteria,3N7WW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7490052_8	717785.HYPMC_2652	6.235e-64	221.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_7499737_5	670307.HYPDE_24413	6.711e-124	404.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3N6XJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7499737_0	1267005.KB911255_gene2533	0.0	1224.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,3N6EZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_7499737_2	582899.Hden_0377	3.327e-189	598.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,3N684@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_7499737_9	1267005.KB911255_gene2530	1.333e-55	196.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,3N6XI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_7499737_12	1267005.KB911255_gene2529	3.656e-32	126.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria,3N7A5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_7499737_6	1267005.KB911255_gene2460	4.295e-85	284.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,3N6RM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_7499737_4	1449065.JMLL01000010_gene952	3.951e-143	470.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,43HI5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_7499737_8	1267005.KB911256_gene1484	1.703e-66	233.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,3N7CK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_7499737_1	1411123.JQNH01000001_gene2503	3.319e-223	707.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7499737_11	1040989.AWZU01000025_gene6289	4.025e-39	154.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2TVR6@28211|Alphaproteobacteria,3JVZC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD1_k127_7499737_7	717785.HYPMC_3714	2.188e-71	246.0	COG4101@1|root,COG4101@2|Bacteria,1RIFZ@1224|Proteobacteria,2VG5Y@28211|Alphaproteobacteria,3N8J5@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7499737_3	1267005.KB911255_gene2418	4.149e-175	560.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,3N6R8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	smoM	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0031317,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0071702,GO:1990351	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7499737_10	631454.N177_0528	8.67e-50	185.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,1JPAE@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	MobA-like NTP transferase domain	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_7499737_13	1298858.AUEL01000010_gene3897	6.068e-18	88.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2U5T0@28211|Alphaproteobacteria,43JQ9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD1_k127_7503165_2	1267005.KB911265_gene3646	1.483e-31	127.0	COG3637@1|root,COG3637@2|Bacteria,1REQH@1224|Proteobacteria,2U73B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cellulose biosynthesis protein BcsS	-	-	-	-	-	-	-	-	-	-	-	-	CBP_BcsS
HKD1_k127_7503165_1	670307.HYPDE_38093	2.877e-78	267.0	COG5342@1|root,COG5342@2|Bacteria,1NA8M@1224|Proteobacteria,2TSY3@28211|Alphaproteobacteria,3N739@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Invasion associated locus B	MA20_19790	-	-	-	-	-	-	-	-	-	-	-	IalB
HKD1_k127_7503165_0	1267005.KB911255_gene2929	1.167e-93	317.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,3N6MH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
HKD1_k127_7503165_3	1267005.KB911255_gene2930	5.599e-27	113.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_7558680_5	1380394.JADL01000014_gene192	1.041e-05	48.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2TV81@28211|Alphaproteobacteria,2JWGM@204441|Rhodospirillales	204441|Rhodospirillales	K	UTRA	-	-	-	-	-	-	-	-	-	-	-	-	GntR,UTRA
HKD1_k127_7558680_0	1187851.A33M_3206	3.68e-230	727.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria,3FD8X@34008|Rhodovulum	28211|Alphaproteobacteria	P	Alkaline phosphatase homologues	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
HKD1_k127_7558680_3	411684.HPDFL43_16666	1.979e-33	135.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,43K3G@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1178)	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HKD1_k127_7558680_1	717785.HYPMC_4434	2.661e-120	392.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,3N6QQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	MA20_39720	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD1_k127_7558680_4	582899.Hden_3189	8.587e-31	123.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,3N774@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD1_k127_7558680_2	1267005.KB911257_gene677	2.622e-80	278.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,3N6YT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_7576731_1	622637.KE124774_gene4006	3.95e-83	302.0	COG2202@1|root,COG3920@1|root,COG2202@2|Bacteria,COG3920@2|Bacteria,1NWNJ@1224|Proteobacteria,2U720@28211|Alphaproteobacteria,36YF6@31993|Methylocystaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,HWE_HK,PAS_3
HKD1_k127_7576731_3	1079460.ATTQ01000006_gene3429	1.287e-24	104.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,4BGUM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HKD1_k127_7576731_2	395963.Bind_3241	5.438e-64	226.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,3NAJW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	sigH	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7576731_0	1120983.KB894574_gene1124	1.309e-91	311.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,1JN3X@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
HKD1_k127_7630144_5	663610.JQKO01000005_gene2518	0.0001727	45.0	COG3027@1|root,COG3027@2|Bacteria,1N8NY@1224|Proteobacteria,2UCRX@28211|Alphaproteobacteria,3NBHA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	MA20_17980	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD1_k127_7630144_0	648757.Rvan_0620	5.061e-164	522.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,3N6HM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_7630144_2	1121920.AUAU01000012_gene2703	2.043e-89	300.0	COG2102@1|root,COG2102@2|Bacteria,3Y46Z@57723|Acidobacteria	57723|Acidobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
HKD1_k127_7630144_1	1267005.KB911258_gene351	9.532e-110	361.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3N7K2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD1_k127_7630144_4	240016.ABIZ01000001_gene1338	3.657e-05	46.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	cbh	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
HKD1_k127_7645612_1	1267005.KB911259_gene3816	2.779e-208	652.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,3N6AT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_7645612_0	709797.CSIRO_2544	5.265e-265	828.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,3JTPC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter C-terminal domain	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
HKD1_k127_7817214_11	1123229.AUBC01000018_gene3682	1.57e-41	158.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2TYJM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_7817214_4	582899.Hden_2895	2.997e-74	259.0	COG4233@1|root,COG4233@2|Bacteria,1REVE@1224|Proteobacteria,2VEXK@28211|Alphaproteobacteria,3N7F9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
HKD1_k127_7817214_5	582899.Hden_2894	8.257e-73	248.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,3N71K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Redoxin	MA20_20905	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD1_k127_7817214_7	78245.Xaut_2357	5.993e-69	240.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,3EZ7H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD1_k127_7817214_0	582899.Hden_2892	9.335e-151	482.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,3N76Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD1_k127_7817214_1	717785.HYPMC_4169	2.236e-142	458.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,3N6IE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD1_k127_7817214_6	1267005.KB911255_gene2949	9.883e-71	248.0	2CB63@1|root,3349C@2|Bacteria,1RKRV@1224|Proteobacteria,2U0FI@28211|Alphaproteobacteria,3N7GN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7817214_9	717785.HYPMC_4166	1.963e-55	198.0	COG0711@1|root,COG0711@2|Bacteria,1N0P5@1224|Proteobacteria,2U5DD@28211|Alphaproteobacteria,3N74E@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_7817214_10	582899.Hden_2888	4.233e-54	196.0	COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,3N7A7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF2	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_7817214_13	670307.HYPDE_37983	2.036e-30	132.0	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria,3N77Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_7817214_3	1267005.KB911255_gene2956	6.41e-110	361.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,3N6S1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_7817214_12	717785.HYPMC_4162	9.785e-37	143.0	COG5336@1|root,COG5336@2|Bacteria,1NCP0@1224|Proteobacteria,2UIHH@28211|Alphaproteobacteria,3N7CF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD1_k127_7817214_8	1297863.APJF01000013_gene3878	2.062e-66	254.0	COG1752@1|root,COG3179@1|root,COG1752@2|Bacteria,COG3179@2|Bacteria,1NEGU@1224|Proteobacteria,2U3U4@28211|Alphaproteobacteria,3JVZK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	chitinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7817214_2	1267005.KB911255_gene2958	2.836e-121	392.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3N655@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
HKD1_k127_7990946_2	717785.HYPMC_1604	2.422e-125	404.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2TRJX@28211|Alphaproteobacteria,3N7VD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD1_k127_7990946_1	1267005.KB911258_gene632	5.463e-232	732.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3N6HH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_7990946_3	1267005.KB911264_gene3108	5.63e-102	342.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,2VF16@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
HKD1_k127_7990946_0	1267005.KB911258_gene633	7.914e-319	987.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,3N6H6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_80047_6	713587.THITH_07195	3.261e-26	110.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_80047_5	187272.Mlg_1729	2.204e-49	180.0	COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,1S8F6@1236|Gammaproteobacteria,1X1E9@135613|Chromatiales	135613|Chromatiales	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD1_k127_80047_2	991905.SL003B_1082	1.51e-139	453.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria,4BS2Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_80047_1	991905.SL003B_1083	4.155e-140	458.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,4BRTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_80047_3	395964.KE386496_gene2440	2.333e-107	359.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,3N9RE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_80047_0	991905.SL003B_1085	7.474e-150	482.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,4BQ89@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_80047_4	187303.BN69_1905	1.262e-102	338.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2U4Q3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_8033664_10	1127673.GLIP_2679	0.0001651	44.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8033664_9	1502724.FF80_02224	1.514e-10	63.0	2EGIV@1|root,33AB2@2|Bacteria,1NHS9@1224|Proteobacteria,2UJHH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD1_k127_8033664_3	717785.HYPMC_1472	4.581e-144	464.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Rod shape-determining protein (MreB)	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_8033664_1	1267005.KB911258_gene198	7.591e-285	882.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,3N660@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_8033664_4	1267005.KB911258_gene202	9.149e-136	439.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,3N6RR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	phenazine biosynthesis protein PhzF family	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_8033664_7	1267005.KB911258_gene203	7.263e-49	187.0	COG0494@1|root,COG0494@2|Bacteria,1RCHK@1224|Proteobacteria,2U68M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8033664_2	1267005.KB911258_gene174	1.275e-196	619.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,3N6FM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD1_k127_8033664_5	1267005.KB911258_gene172	1.763e-88	299.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,3N6SY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Acetolactate synthase	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_8033664_0	1267005.KB911258_gene170	0.0	1084.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,3N621@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Acetolactate synthase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_8033664_6	1267005.KB911258_gene169	2.138e-69	241.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,3N6UJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_821754_6	290400.Jann_3438	1.015e-13	76.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the pirin family	yhhW	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_821754_5	1502851.FG93_03332	2.688e-14	74.0	COG2813@1|root,COG2813@2|Bacteria,1QWWU@1224|Proteobacteria,2TX6V@28211|Alphaproteobacteria,3K6SJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	O-methyltransferase	crtF	-	2.1.1.210	ko:K09846	ko00906,ko01100,map00906,map01100	-	R07521,R07524,R07527,R07529,R07533,R07535	RC00003,RC02082	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_821754_2	1267005.KB911255_gene2580	4.883e-63	234.0	COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,2U9JW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09974	-	-	-	-	ko00000	-	-	-	DUF1287
HKD1_k127_821754_0	1267005.KB911255_gene2578	2.31e-117	392.0	COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,3N717@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	LppC putative lipoprotein	MA20_24635	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_821754_1	1267005.KB911255_gene2577	1.219e-111	368.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,3N6RW@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD1_k127_821754_4	1267005.KB911255_gene2576	2.208e-28	127.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,3N797@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the UPF0102 family	MA20_24645	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_821754_3	118166.JH976537_gene4348	1.436e-38	147.0	COG3752@1|root,COG3752@2|Bacteria,1G0MQ@1117|Cyanobacteria,1H94W@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
HKD1_k127_91550_6	1267005.KB911260_gene3465	1.484e-54	196.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UCNU@28211|Alphaproteobacteria,3N7FR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_91550_7	1267005.KB911260_gene3464	4.377e-48	180.0	29KMP@1|root,2Z9ZF@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HKD1_k127_91550_1	1267005.KB911260_gene3463	2.427e-168	540.0	28JPV@1|root,2Z9FT@2|Bacteria,1PJPU@1224|Proteobacteria,2U5WB@28211|Alphaproteobacteria,3N7ZA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_91550_9	717785.HYPMC_1278	9.465e-34	135.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,3N9CP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	MA20_05250	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_91550_11	1163398.AJJP01000074_gene2545	6.221e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,1S7GR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase	ats	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_91550_0	1267005.KB911260_gene3459	1.951e-168	546.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,3N68K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD1_k127_91550_4	1267005.KB911260_gene3458	2.089e-87	299.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TUBN@28211|Alphaproteobacteria,3N8V3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_91550_3	1267005.KB911260_gene3457	4.017e-100	338.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TR9X@28211|Alphaproteobacteria,3N9EX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_91550_5	1267005.KB911262_gene3312	2.088e-57	214.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2UFVP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	rRNA binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	-
HKD1_k127_91550_2	1120792.JAFV01000001_gene137	4.026e-150	484.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,36XJ4@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD1_k127_92641_4	189753.AXAS01000012_gene4257	1.349e-26	115.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl,OMP_b-brl_2
HKD1_k127_92641_1	1267005.KB911258_gene154	3.828e-146	472.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,3N80Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	4Fe-4S single cluster domain	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
HKD1_k127_92641_3	1297865.APJD01000011_gene6873	1.848e-35	139.0	COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,2U94Y@28211|Alphaproteobacteria,3K17B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD1_k127_92641_0	582899.Hden_1433	0.0	1300.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,3N619@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_92641_2	1267005.KB911255_gene2930	9.717e-65	223.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3N6KY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_93263_3	1267005.KB911256_gene2084	1.178e-73	250.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,3N6RT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_93263_2	1267005.KB911256_gene2085	1.536e-79	268.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,3N6UC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_93263_6	717785.HYPMC_2607	5.114e-48	179.0	2ED53@1|root,3371U@2|Bacteria,1MUY2@1224|Proteobacteria,2U1AB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_93263_1	1267005.KB911256_gene2087	6.411e-101	335.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,3N8G3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_93263_5	582899.Hden_1393	5.321e-55	196.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2UC5P@28211|Alphaproteobacteria,3N9AU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_93263_4	648757.Rvan_1710	1.063e-67	234.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,3N8VD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	CoA binding domain	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_93263_0	189753.AXAS01000012_gene4364	2.2e-133	434.0	COG0834@1|root,COG0834@2|Bacteria,1NN6F@1224|Proteobacteria,2TSA4@28211|Alphaproteobacteria,3JVI5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Ligand-gated ion channel	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	Lig_chan,SBP_bac_3
HKD1_k127_93263_7	631454.N177_0964	3.172e-27	115.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2UBTC@28211|Alphaproteobacteria,1JQBU@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Lytic transglycolase	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
## 2483 queries scanned
## Total time (seconds): 122.58473587036133
## Rate: 20.26 q/s